CN117815533A

CN117815533A - Perfusate injection device and control method thereof

Info

Publication number: CN117815533A
Application number: CN202211183087.1A
Authority: CN
Inventors: 薛志宽; 高玲玲
Original assignee: Fengkaili Medical Instrument Shanghai Co ltd
Current assignee: Fengkaili Medical Instrument Shanghai Co ltd
Priority date: 2022-09-27
Filing date: 2022-09-27
Publication date: 2024-04-05

Abstract

The application provides a perfusion fluid injection device and a control method thereof. The perfusate injection device comprises a transmission pipeline, an input pump, an exhaust pump, a detection component and a control component. The transmission pipeline is used for being intervened in the target tissue along with the blood pumping equipment, and the transmission pipeline is equipped with input runner and discharge runner, and input runner and discharge runner set up side by side along the axial of transmission pipeline, and input runner and discharge runner are in transmission pipeline's distal end department intercommunication each other, and input runner and human body fluid environment intercommunication. The input pump is connected to the proximal end of the transfer line and communicates with the input flow channel. The discharge pump is connected to the proximal end of the transfer line and communicates with the discharge flow passage. The detection component is configured to acquire a blood pressure value at a target location. The control unit is electrically connected to the input pump, the discharge pump, and the detection unit, and controls the flow rate of the input pump or the flow rate of the discharge pump according to the blood pressure value. According to the embodiment of the application, the occurrence of the condition that blood flows into the transmission system of the blood pumping equipment can be effectively reduced or avoided.

Description

Perfusate injection device and control method thereof

Technical Field

The application relates to the technical field of medical equipment, in particular to a perfusion fluid injection device and a control method thereof.

Background

Currently, cardiovascular disease has become a significant cause of death in humans, heart transplantation is an effective means of treating critically ill heart patients, however in reality there are far more heart acceptors than heart donors, resulting in death of the patient waiting for heart transplantation. The percutaneous blood pumping auxiliary equipment can assist heart to pump blood, and is a common equipment for assisting in treating cardiovascular diseases. The percutaneous blood pumping auxiliary equipment comprises a blood pumping conduit and a transmission system connected with the blood pumping conduit, wherein the blood pumping conduit comprises an impeller, the transmission system comprises a rotating part and a fixing part, and the rotating part drives the impeller to work.

For example, conventional percutaneous pumping aids access the left ventricle of the human heart by minimally invasive surgery to assist the heart in pumping blood. Under the operating condition, the blood pumping catheter and part of the transmission system are positioned in a human body, blood can flow into the transmission system from a gap between the rotating part and the fixed part in the process of pumping blood by the heart pumping catheter, and a large amount of blood enters the transmission system to influence the normal operation of the transmission system, so that the problems of load increase, transmission failure and the like are caused, and therefore, in the field of medical equipment, the transmission system of blood pumping equipment is prevented from flowing into the blood by filling the perfusion liquid through a perfusion liquid injection device. Meanwhile, in the working process of the transmission system, redundant perfusate is also required to be discharged out of the body along the reverse direction of the perfusate direction.

However, under the condition of pressure change in the aorta, if the input flow and the discharge flow of the perfusate are unsuitable, part of blood still flows into the transmission system of the blood pumping device, so that the normal operation of the transmission system is affected, and the problems of load increase, transmission failure and the like are caused. In view of this, improvements in the perfusion fluid injection apparatus are needed.

Disclosure of Invention

In view of the above, the present application provides a perfusate injection device and a control method thereof, which can effectively reduce or avoid the occurrence of the situation that blood flows into a transmission system of a blood pumping device.

In a first aspect, embodiments of the present application provide a perfusate injection device for a blood pumping apparatus, the perfusate injection device comprising a transfer line, an input pump, an output pump, a detection component, and a control component. The transmission pipeline is used for being intervened in the target tissue along with the blood pumping equipment, and the transmission pipeline is equipped with input runner and discharge runner, and input runner and discharge runner set up side by side along the axial of transmission pipeline, and input runner and discharge runner are in transmission pipeline's distal end department intercommunication each other, and input runner and human body fluid environment intercommunication. The input pump is connected to the proximal end of the transfer line and communicates with the input flow channel. The discharge pump is connected to the proximal end of the transfer line and communicates with the discharge flow passage. The detection component is configured to acquire a blood pressure value at a target location. The control unit is electrically connected to the input pump, the discharge pump, and the detection unit, and controls the flow rate of the input pump or the flow rate of the discharge pump according to the blood pressure value.

In some embodiments of the first aspect, the detection component is distributed along the transmission line, the detection component includes a conductive member and a collection member, one end of the conductive member is located at a distal end of the transmission line, the other end is connected to the collection member, and the collection member is disposed at a proximal end of the transmission line.

In some embodiments of the first aspect, the conductive element is embedded in an outer wall of the transfer line.

In some embodiments of the first aspect, the conductive element comprises a hose structure having a cavity filled with a liquid. The collection piece comprises a collection module and a display screen, and the collection module is electrically connected with the hose structure and the display screen.

In some embodiments of the first aspect, the control component includes a communication module that obtains a blood pressure value of the detection component, a calculation module that generates a control signal based on the blood pressure value, and a regulation module that controls a flow rate of the input pump or a flow rate of the discharge pump based on the control signal.

In some embodiments of the first aspect, the inlet pump is provided with a check valve at the outlet and at the inlet of the discharge pump.

In a second aspect, an embodiment of the present application provides a control method of a perfusate injection device, applied to any one of the perfusate injection devices in the first aspect, the control method including:

acquiring a blood pressure value at a target location;

and controlling the flow rate of the input pump or the flow rate of the discharge pump according to the blood pressure value, wherein the flow rate of the input pump is larger than the flow rate of the discharge pump.

In some embodiments of the second aspect, prior to acquiring the blood pressure value at the target location, the control method further comprises:

controlling the transmission pipeline to be filled with perfusion liquid;

the pump blood flow of the pump blood equipment and the flow of the input pump are controlled to be the first preset flow, or the pump blood flow of the pump blood equipment and the flow of the discharge pump are controlled to be the second preset flow.

In some embodiments of the second aspect, controlling the flow rate of the input pump or the flow rate of the output pump in accordance with the blood pressure value comprises:

generating a first target flow according to the blood pressure value and a first mapping relation under the condition that the flow of the input pump is a first preset flow, wherein the first mapping relation is the mapping relation between the blood pressure value and the flow of the discharge pump;

and controlling the flow rate of the discharge pump to be a first target flow rate, wherein the first preset flow rate is larger than the first target flow rate.

generating a second target flow according to the blood pressure value and a second mapping relation under the condition that the flow of the discharge pump is a second preset flow, wherein the second mapping relation is a mapping relation between the blood pressure value and the flow of the input pump;

and controlling the flow rate of the input pump to be a second target flow rate, wherein the second preset flow rate is smaller than the second target flow rate.

According to the perfusate injection device and the control method thereof, the detection component and the control component are arranged in the perfusate injection device, the detection component can acquire the blood pressure value of the aorta of the human body, the control component is electrically connected with the input pump, the discharge pump and the detection component, and the control component can dynamically control the flow of the input pump or the flow of the discharge pump according to the blood pressure value, so that the blood pressure of the blood flowing into the blood vessel of the human body and the aorta at the far end of the transmission pipeline can be kept in a proper state, and the occurrence of the condition that blood flows into the transmission system of the blood pumping device can be effectively reduced or avoided.

The foregoing description is only an overview of the technical solutions of the present application, and may be implemented according to the content of the specification in order to make the technical means of the present application more clearly understood, and in order to make the above-mentioned and other objects, features and advantages of the present application more clearly understood, the following detailed description of the present application will be given.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the application. Also, like reference numerals are used to designate like parts throughout the figures. In the drawings:

fig. 1 is a schematic structural diagram of a perfusion fluid injection device according to some embodiments of the present disclosure;

fig. 2 is a flow chart of a control method of a perfusion apparatus according to some embodiments of the present application.

Reference numerals in the specific embodiments are as follows:

10. a transmission line; 11. an input flow channel; 12. a discharge flow path; 13. a shunt structure; 131. an outer layer cavity; 132. an inner layer cavity; 20. an input pump; 21. an infusion bag; 30. a discharge pump; 31. a waste liquid bag; 40. a detection section; 41. a conductive member; 42. a collection member; 50. a control part; 60. a rotating member; 70. an impeller; 80. a one-way valve.

Detailed Description

Embodiments of the technical solutions of the present application will be described in detail below with reference to the accompanying drawings. The following examples are only for more clearly illustrating the technical solutions of the present application, and thus are only examples, and are not intended to limit the scope of protection of the present application.

It should be noted that unless otherwise indicated, technical or scientific terms used in the embodiments of the present application should be given the ordinary meanings as understood by those skilled in the art to which the embodiments of the present application belong.

In the description of the embodiments of the present application, the technical terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom".

The references to the orientation or positional relationship of "inner", "outer", "clockwise", "counter-clockwise", "axial", "radial", "circumferential", etc. are based on the orientation or positional relationship shown in the drawings, are merely for convenience in describing the embodiments of the present application and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the embodiments of the present application.

Furthermore, the technical terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the description of the embodiments of the present application, the meaning of "plurality" is two or more unless explicitly defined otherwise.

In the description of the embodiments of the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured" and the like are to be construed broadly and may, for example, be fixedly connected, detachably connected, or be integrated; or may be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the embodiments of the present application will be understood by those of ordinary skill in the art according to the specific circumstances.

In the description of embodiments of the present application, unless explicitly specified and limited otherwise, a first feature "up" or "down" on a second feature may be that the first and second features are in direct contact, or that the first and second features are in indirect contact via an intermediary. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

At present, the traditional percutaneous blood pumping auxiliary equipment enters the left ventricle of the heart of the human body in a minimally invasive surgery mode and is used for assisting the heart to pump blood. Under the operating condition, the blood pumping catheter and part of the transmission system are positioned in a human body, blood can flow into the transmission system from a gap between the rotating part and the fixed part in the process of pumping blood by the heart pumping catheter, and a large amount of blood enters the transmission system to influence the normal operation of the transmission system, so that the problems of load increase, transmission failure and the like are caused, and therefore, in the field of medical equipment, the transmission system of blood pumping equipment is prevented from flowing into the blood by filling the perfusion liquid through a perfusion liquid injection device. Meanwhile, in the working process of the transmission system, redundant perfusate is also required to be discharged out of the body along the reverse direction of the perfusate direction.

Taking the left ventricle intervention blood pumping device as an example, a blood outflow port of the blood pumping device is positioned in an aorta, and the flow direction of blood pumping or the flow direction of natural blood in the aorta is opposite to the input flow direction of the perfusate and is the same as the discharge direction of the perfusate. The applicant of the present application noted that, because intra-aortic blood pressure is a periodic variation process, if the infusion flow and the discharge flow of the perfusate are inappropriate under the condition of intra-aortic blood pressure variation, for example, when intra-aortic blood pressure is large, part of blood still flows into the transmission system of the blood pumping device, which affects the normal operation of the transmission system, resulting in problems of increased load, transmission failure, and the like.

The applicant of the application researches and discovers that the detecting component and the control component can be arranged in the perfusate injection device, the detecting component can acquire the blood pressure value of the aorta of the human body, the control component is electrically connected with the input pump, the discharge pump and the detecting component, and the control component can dynamically control the flow of the input pump or the flow of the discharge pump according to the blood pressure value, so that the pressure of the perfusate flowing into the blood vessel of the human body at the far end of the transmission pipeline and the blood pressure in the aorta are kept in a proper state, and the situation that blood flows into a transmission system of the blood pumping device can be effectively reduced or avoided.

In order to solve the problems in the prior art, embodiments of the present application provide a perfusate injection device and a control method thereof, which can dynamically regulate and control the flow rate of perfusate in the perfusate injection device according to the blood pressure, thereby effectively improving the phenomenon that blood flows into a transmission system of a blood pumping device. The following first describes a phase adjuster provided in an embodiment of the present application.

Fig. 1 is a schematic structural diagram of a perfusion apparatus according to some embodiments of the present application.

As shown in fig. 1, an embodiment of the present application provides a perfusate injection device for a blood pumping apparatus, the perfusate injection device including: the blood pump comprises a transmission pipeline 10, an input pump 20, an output pump 30, a detection component 40 and a control component 50, wherein the transmission pipeline 10 is used for being inserted into target tissues along with blood pumping equipment, the transmission pipeline 10 is provided with an input runner 11 and an output runner 12, the input runner 11 and the output runner 12 are arranged side by side along the axial direction of the transmission pipeline 10, the input runner 11 and the output runner 12 are communicated with each other at the far end of the transmission pipeline 10, and the input runner 11 is communicated with the human body fluid environment. An inlet pump 20 is connected to the proximal end of the transfer line 10 and communicates with the inlet flow passage 11. An evacuation pump 30 is connected to the proximal end of the transfer line 10 and communicates with the evacuation flow path 12. The detection component 40 is configured to acquire a blood pressure value at a target location. The control unit 50 is electrically connected to the input pump 20, the discharge pump 30, and the detection unit 40, and the control unit 50 controls the flow rate of the input pump 20 or the flow rate of the discharge pump 30 according to the blood pressure value.

The perfusate injection device in the embodiment of the application is applied to blood pumping equipment, the blood pumping equipment can be percutaneous blood pumping auxiliary equipment, the percutaneous blood pumping auxiliary equipment can assist heart blood pumping, and the perfusion device is common equipment for assisting treatment of cardiovascular diseases. The percutaneous blood pumping auxiliary equipment comprises a blood pumping catheter and a transmission system connected with the blood pumping catheter, wherein the blood pumping catheter comprises an impeller 70, the transmission system comprises a rotating part 60 and a fixing part, and the rotating part 60 drives the impeller 70 to work.

In the present embodiment, the delivery line 10 is used to intervene with a pumping device in a target tissue, which may be the left ventricle of a human heart. The transfer line 10 is provided with an inlet flow passage 11 and an outlet flow passage 12, and the inlet flow passage 11 and the outlet flow passage 12 are arranged side by side in the axial direction of the transfer line 10. Illustratively, the transfer tubing 10 may be a multi-layered tube structure or a multi-lumen tube structure. When the transmission pipeline 10 is of a multilayer pipe structure, the multilayer pipe structure comprises an inner sheath pipe and an outer sheath pipe, the outer sheath pipe is sleeved on the inner sheath pipe, an input flow passage 11 is formed between the outer sheath pipe and the inner sheath pipe, and an exhaust flow passage 12 is formed inside the inner sheath pipe. When the transfer line 10 is a multi-lumen tube structure, the multi-lumen tube structure includes at least two lumen tubes, one of which is an inlet flow passage 11 and one of which is an outlet flow passage 12.

In the embodiment of the present application, the distal end is the end that enters the inside of the human target tissue, and the proximal end is the end that is outside of the human target tissue. The input flow channel 11 and the discharge flow channel 12 communicate with each other at the distal end of the transfer line 10, and the input flow channel 11 communicates with the human body fluid environment. After entering the input flow channel 11, the perfusate is split into two paths at the distal end of the transmission pipeline 10, one path flows into the body fluid environment of the human body, and the other path flows into the discharge flow channel 12 to return to the proximal end of the transmission pipeline 10.

In some alternative embodiments, the distal end of the transmission line 10 is provided with a flow dividing structure 13, the flow dividing structure 13 includes an outer cavity 131 and an inner cavity 132, the input flow channel 11 communicates with the outer cavity 131 to form an outer layer passage, and the discharge flow channel 12 communicates with the inner cavity 132 to form an inner layer passage. After entering the input flow channel 11, the perfusate is split into two paths at the distal end of the transmission pipeline 10 through the splitting structure 13, one path flows into the body fluid environment of the human body, and the other path flows into the discharge flow channel 12 to return to the proximal end of the transmission pipeline 10.

Both the inlet pump 20 and the outlet pump 30 are connected to the proximal end of the transfer line 10. Alternatively, the input pump 20 may be connected to the infusion bag 21 and the discharge pump 30 may be connected to the waste bag 31. The infusion pump 20 continuously pumps the perfusion liquid in the infusion bag 21 into the infusion flow channel 11, and the discharge pump 30 continuously pumps the perfusion liquid in the discharge flow channel 12 into the waste liquid bag 31. The perfusate may be, but is not limited to, a heparin solution of glucose or a heparin solution of physiological saline, etc.

The detection component 40 is configured to acquire a blood pressure value at a target location. In the embodiment of the present application, the target site may be an aorta of a human body, and the detecting part 40 may be a pressure sensor. The specific location of the target location may be various, for example, the target location may be a location near the distal end of the transmission line 10 in the aorta of the human body, or a location near the proximal end of the transmission line 10 in the aorta of the human body.

The control part 50 is electrically connected to the detection part 40, and the detection part 40 is capable of transmitting the acquired blood pressure value at the target position into the control part 50. The control unit 50 is also electrically connected to the input pump 20 and the discharge pump 30, and the control unit 50 can control the flow rate of the input pump 20 or the flow rate of the discharge pump 30 according to the blood pressure value.

Illustratively, the control unit 50 sets the perfusate injection flow rate of the input pump 20 to a constant first preset flow rate when controlling the flow rate of the discharge pump 30 according to the blood pressure value. The control part 50 can dynamically control the waste liquid discharge flow rate of the discharge pump 30 according to the blood pressure value detected by the detecting part 40 so that the perfusion pressure flowing out to the pump-blood conduit at the distal end of the transmission line 10 is kept in a proper state with the blood pressure in the aorta. The corresponding relationship between the waste liquid discharge flow rate of the discharge pump 30 and the blood pressure value in the aorta is obtained through experiments in advance and is loaded into the software program of the control unit 50, that is, each blood pressure value detected by the detection unit 40 corresponds to the waste liquid discharge flow rate of one discharge pump 30. Wherein the first preset flow rate of the input pump 20 is controlled to be 5ml/h to 80ml/h. In this regard, the term "flow rate" is generally used in this field, but the flow rate is substantially defined as a liquid flow rate.

The control section 50 sets the waste liquid discharge flow rate of the discharge pump 30 to a constant second preset flow rate when controlling the flow rate of the input pump 20 according to the blood pressure value. The control part 50 can dynamically control the perfusion fluid injection flow rate of the input pump 20 according to the blood pressure value detected by the detection part 40 so that the perfusion fluid pressure flowing out to the pump blood conduit at the distal end of the transmission line 10 maintains a proper state with the blood pressure in the aorta. The corresponding relationship curve between the perfusate injection flow rate of the input pump 20 and the blood pressure value in the aorta is obtained through experiments in advance, and is loaded into the software program of the control unit 50, that is, each blood pressure value detected by the detection unit 40 corresponds to the perfusate injection flow rate of one input pump 20. Wherein the second preset flow rate of the discharge pump 30 is controlled to be 4ml/h to 60ml/h.

During the operation of the whole perfusate injection device, the perfusate injection flow rate of the input pump 20 is larger than the waste liquid discharge flow rate of the discharge pump 30.

In the above technical solution, by arranging the detecting component 40 and the control component 50 in the perfusate injection device, the detecting component 40 can obtain the blood pressure value of the aorta of the human body, the control component 50 is electrically connected to the input pump 20, the discharge pump 30 and the detecting component 40, and the control component 50 can dynamically control the flow of the input pump 20 or the flow of the discharge pump 30 according to the blood pressure value, so that the perfusate pressure flowing into the blood vessel of the human body at the distal end of the transmission pipeline 10 and the blood pressure in the aorta keep a proper state, and further, the occurrence of the situation that blood flows into the transmission system of the blood pumping device can be effectively reduced or avoided.

In some embodiments, the detection member 40 is distributed along the delivery line 10, the detection member 40 comprises a conductive element 41 and a collection element 42, one end of the conductive element 41 is located at the distal end of the delivery line 10, the other end is connected to the collection element 42, and the collection element 42 is disposed at the proximal end of the delivery line 10. The conductive member 41 comprises a hose structure having a cavity filled with a liquid. The collection member 42 includes a collection module and a display screen, and the collection module is electrically connected to the hose structure and the display screen.

The detecting members 40 are distributed along the transmission line 10, and the distal ends of the detecting members 40 are located in the aorta inside the human body, so that the blood pressure value of the aorta can be obtained. The proximal end of the detecting member 40 is located outside the human body, is electrically connected to the control member 50, and is capable of transmitting the blood pressure value of the aorta acquired at the distal end of the detecting member 40 to the control member 50.

Alternatively, a portion of the conductive member 41 is located in the aorta inside the human body, and another portion is located outside the human body and connected to the acquisition member 42. The hose structure of the conducting member 41 is filled with a liquid, the blood of the aorta at the distal end of the transfer line 10 applies pressure to the conducting member 41, the liquid in the hose structure conducts the blood pressure to the collecting member 42, the collecting module in the collecting member 42 generates a blood pressure value, and the blood pressure value is transferred to the control member 50. The display screen can display the blood pressure value in real time.

In the above technical solution, by arranging the conductive member 41 of the detecting component 40 in a hose structure and arranging the collecting member 42 having the collecting module, the display screen and other electronic devices outside the human body, the influence of the detecting component 40 on the human body can be effectively reduced. Meanwhile, the display screen can display the blood pressure value in real time, so that operators can timely cope with abnormal conditions.

In some embodiments, the conductive member 41 is embedded in the outer wall of the transmission pipeline 10, so that the occurrence of displacement or vibration of the conductive member 41 in the aorta of the human body can be reduced, errors in blood pressure conduction can be reduced, and the stability of the detecting component 40 can be improved.

In some embodiments, the control component 50 includes a communication module that obtains the blood pressure value of the detection component 40, a calculation module that generates a control signal based on the blood pressure value, and a regulation module that controls the flow rate to the pump 20 or the flow rate from the discharge pump 30 based on the control signal.

The communication module is used for receiving and transmitting data of the control module, the calculation module is used for processing the data, and the regulation and control module is used for controlling the flow of the input pump 20 or the flow of the discharge pump 30. The calculation module includes a corresponding relationship between the waste liquid discharge flow of the discharge pump 30 and the blood pressure value in the aorta, and a corresponding relationship between the perfusate injection flow of the input pump 20 and the blood pressure value in the aorta.

Specifically, the detecting unit 40 transmits the detected blood pressure value to the communication module, the communication module transmits the blood pressure value to the calculation module, the calculation module generates a control signal according to the blood pressure value and transmits the control signal to the communication module, the communication module transmits the control signal to the regulation module, and the regulation module controls the flow rate of the input pump 20 or the flow rate of the discharge pump 30 according to the control signal.

In some alternative embodiments, a rotary member 60 in the pumping device drive train is disposed in the discharge flow path 12.

As described above, the blood pumping device comprises a blood pumping duct and a transmission system connected with the blood pumping duct, wherein the transmission system comprises a rotating part 60 and a fixing part, and the rotating part 60 drives the blood pumping duct to work. During operation of the blood pumping apparatus, the rotating member 60 may generate wear particles because the rotating member 60 rotates at a high speed and the rotating member 60 may be bent along with the vascular structure while passing through the complicated vascular structure. Optionally, the rotating member 60 comprises a drive wringing or bearing or the like.

The wear particles in the transfer line 10 are mainly generated by the rotating member 60 located in the discharge flow channel 12, and the perfusion liquid carrying the wear particles in the discharge flow channel 12 will be pumped out by the discharge pump 30 located at the proximal end of the transfer line 10 into the waste bag 31. At the same time, the perfusion fluid, which is free of wear particles, will be transported by the pumping action of the input pump 20 via the input flow channel 11 to the distal end of the transport line 10 into the body fluid environment.

In the above technical solution, by arranging the rotating member 60 in the discharge flow channel 12, the wearing particles generated by the rotating member 60 can be effectively prevented from entering the body fluid environment of the human body, and the reliability of the perfusate injection device is further improved.

In some embodiments, a one-way valve 80 is provided at both the outlet of the input pump 20 and the inlet of the discharge pump 30.

The check valve 80 is used to ensure one-way flow of the perfusate while preventing backflow of the perfusate in the event of pump failure. The check valve 80 may be, but is not limited to, a spring type check valve 80, a gravity type check valve 80, a swing check valve 80, or the like. Specifically, the one-way valve 80 is disposed at the outlet of the input pump 20, so as to effectively prevent the perfusate from flowing backward to reduce the perfusate flow in the transmission pipeline 10, and further to enable the blood to flow into the transmission system of the blood pumping device; the one-way valve 80 is provided at the inlet of the discharge pump 30, so that the waste liquid can be effectively prevented from flowing back and entering the transmission pipeline 10, and then flows into the human body.

In the above technical solution, by providing the check valve 80 at the outlet of the input pump 20 and the inlet of the discharge pump 30, the phenomenon of the backflow of the perfusate can be effectively reduced, and the reliability of the perfusate injection device can be further improved.

With continued reference to fig. 2, based on the perfusate injection device provided in the embodiment of the present application, the embodiment of the present application further provides a control method of the perfusate injection device, where the control method of the perfusate injection device may be applied to the perfusate injection device described in the embodiment of the present application, and the control method includes steps 110 to 120.

At step 110, a blood pressure value at a target location is obtained.

Step 120, controlling the flow rate of the input pump 20 or the flow rate of the discharge pump 30 according to the blood pressure value, wherein the flow rate of the input pump 20 is larger than the flow rate of the discharge pump 30.

The detecting unit 40 in the perfusate injecting device acquires the blood pressure value at the target position, which is the human aorta as described above. The detecting unit 40 transmits the blood pressure value to the control unit 50, and the control unit 50 can generate a control signal according to the blood pressure value, and the control unit 50 controls the flow rate of the input pump 20 or the flow rate of the discharge pump 30 according to the control signal. During the entire operation of the perfusate injection device, the perfusate injection flow rate of the input pump 20 is greater than the waste liquid discharge flow rate of the discharge pump 30.

Illustratively, the control unit 50 sets the perfusate injection flow rate of the input pump 20 to a constant first preset flow rate when controlling the flow rate of the discharge pump 30 according to the blood pressure value. The control part 50 can dynamically control the waste liquid discharge flow rate of the discharge pump 30 according to the blood pressure value detected by the detecting part 40 so that the perfusion pressure flowing out to the pump-blood conduit at the distal end of the transmission line 10 is kept in a proper state with the blood pressure in the aorta. The corresponding relationship between the waste liquid discharge flow rate of the discharge pump 30 and the blood pressure value in the aorta is obtained through experiments in advance and is loaded into the software program of the control unit 50, that is, each blood pressure value detected by the detection unit 40 corresponds to the waste liquid discharge flow rate of one discharge pump 30. Wherein the first preset flow rate of the input pump 20 is controlled to be 5ml/h to 80ml/h.

In some embodiments, prior to acquiring the blood pressure value at the target location, the control method further comprises:

the transfer line 10 is controlled to fill with perfusate.

The flow rate of the pump blood controlling the pump blood device and the flow rate of the input pump 20 are both the first preset flow rate, or the flow rate of the pump blood controlling the pump blood device and the flow rate of the discharge pump 30 are both the second preset flow rate.

Specifically, before the blood pumping apparatus enters the target tissue of the human body, the perfusate injection device is connected to the blood pumping apparatus, the input pump 20 and the discharge pump 30 are started and operated by the control part 50, and the flow rate of the input pump 20 and the flow rate of the discharge pump 30 are adjusted to the highest gear, so that the perfusate rapidly fills the input flow channel 11 and the discharge flow channel 12 of the transmission line 10 until the liquid in the waste liquid bag 31 flows, and then the flow rate of the input pump 20 is adjusted to the lowest gear, and the discharge pump 30 is turned off.

After the blood pumping device enters the target tissue of the human body, the blood pumping device is started, the pump blood flow of the blood pumping device is adjusted to a first preset flow, and the flow of the input pump 20 is adjusted to the first preset flow, so that the input pump 20 can provide a constant perfusion fluid injection flow corresponding to the pump blood flow of the blood pumping device. Wherein the first preset flow is controlled to be 5 ml/h-80 ml/h.

Or, after the blood pumping device enters the target tissue of the human body, the blood pumping device is started, the pump blood flow of the blood pumping device is adjusted to a second preset flow, and the flow of the discharge pump 30 is adjusted to the second preset flow, so that the discharge pump 30 can provide a constant waste liquid discharge flow corresponding to the pump blood flow of the blood pumping device. Wherein the second preset flow rate is controlled to be 4 ml/h-60 ml/h.

In the above-described embodiments, the perfusion fluid is filled in the transfer line 10 before the blood pumping device enters the target tissue of the human body. And in the process that the pumping device enters the inside of the human body, the input pump 20 can provide a constant perfusate injection flow corresponding to the pumping blood flow of the pumping device, or the discharge pump 30 can provide a constant waste liquid discharge flow corresponding to the pumping blood flow of the pumping device, so that the perfusate flow flowing out to the pumping blood conduit at the distal end of the transmission line 10 is balanced with the pumping blood flow of the pumping blood device, and the phenomenon that blood flows into the transmission system of the pumping blood device can be further improved.

In some embodiments, controlling the flow rate of the input pump 20 or the flow rate of the output pump 30 according to the blood pressure value includes:

when the flow rate of the input pump 20 is the first preset flow rate, a first target flow rate is generated from the blood pressure value and a first map, which is a map of the blood pressure value and the flow rate of the discharge pump 30.

The flow rate of the discharge pump 30 is controlled to be a first target flow rate, wherein the first preset flow rate is greater than the first target flow rate.

Specifically, when the perfusate injection flow rate of the input pump 20 is the first preset flow rate, the control unit 50 can generate the first target flow rate according to the blood pressure value detected by the detection unit 40 and the first mapping relationship, so as to dynamically control the perfusate injection flow rate of the input pump 20, so that the perfusate pressure flowing out to the pump blood conduit at the distal end of the transmission line 10 and the blood pressure in the aorta maintain a proper state.

The first target flow is the perfusate injection flow of the input pump 20, and the first mapping relationship is a corresponding relationship curve of the perfusate injection flow of the input pump 20 and the blood pressure value in the aorta. The first map is obtained in advance through experiments and loaded into a software program of the control section 50.

in the case where the flow rate of the discharge pump 30 is the second preset flow rate, the second target flow rate is generated from the blood pressure value and the second map, which is a map of the blood pressure value and the flow rate of the input pump 20.

The flow rate of the input pump 20 is controlled to be a second target flow rate, wherein the second preset flow rate is smaller than the second target flow rate.

Specifically, in the case where the waste liquid discharge flow rate of the discharge pump 30 is the second preset flow rate, the control part 50 is able to generate the second target flow rate according to the blood pressure value of the aorta detected by the detection part 40 and the second map to dynamically control the waste liquid discharge flow rate of the discharge pump 30 so that the perfusion pressure flowing out to the pump-blood conduit at the distal end of the transmission line 10 and the blood pressure in the aorta remain in a proper state.

The second target flow rate is a waste liquid discharge flow rate of the discharge pump 30, and the second map is a correspondence curve between the waste liquid discharge flow rate of the discharge pump 30 and a blood pressure value in the aorta. The second map is obtained in advance through experiments and loaded into the software program of the control section 50.

In some alternative embodiments, the control component may also dynamically regulate the flow rate of the input pump and the flow rate of the output pump simultaneously based on the blood pressure value. It may be appreciated that the specific details of the adjusting and controlling method may be referred to the description of the corresponding parts in the control method of the perfusate injection device described in the embodiments of the present application, and are not repeated herein for brevity.

It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the embodiments, and are intended to be included within the scope of the claims and description. In particular, the technical features mentioned in the respective embodiments may be combined in any manner as long as there is no structural conflict. The present application is not limited to the specific embodiments disclosed herein, but encompasses all technical solutions falling within the scope of the claims.

Claims

1. A perfusate injection device for a blood pumping apparatus, the perfusate injection device comprising:

the transmission pipeline is used for being inserted into a target tissue along with the blood pumping equipment, the transmission pipeline is provided with an input runner and an exhaust runner, the input runner and the exhaust runner are arranged side by side along the axial direction of the transmission pipeline, the input runner and the exhaust runner are mutually communicated at the far end of the transmission pipeline, and the input runner is communicated with the human body fluid environment;

an input pump connected to the proximal end of the transfer line and in communication with the input flow channel;

a discharge pump connected to a proximal end of the transfer line and in communication with the discharge flow passage;

a detection section configured to acquire a blood pressure value at a target position;

and a control unit electrically connected to the input pump, the discharge pump, and the detection unit, the control unit controlling a flow rate of the input pump or a flow rate of the discharge pump according to the blood pressure value.

2. The perfusate injection device according to claim 1, wherein said detection means are distributed along said transmission line, said detection means comprising a conducting member and a collecting member, one end of said conducting member being located at the distal end of said transmission line, the other end being connected to the collecting member, said collecting member being located at the proximal end of said transmission line.

3. The perfusate injection device according to claim 2, wherein said conducting member is embedded in an outer wall of said transmission line.

4. The perfusate injection device of claim 2, wherein said conductive member comprises a hose structure having a cavity filled with a liquid;

the collection piece comprises a collection module and a display screen, and the collection module is electrically connected with the hose structure and the display screen.

5. The perfusate injection device according to claim 1, wherein said control means comprises a communication module, a calculation module and a regulation module, said communication module obtaining a blood pressure value of said detection means, said calculation module generating a control signal according to said blood pressure value, said regulation module controlling a flow rate of said input pump or a flow rate of said discharge pump according to said control signal.

6. The perfusate injection device according to claim 1, wherein a one-way valve is provided at both the outlet of said input pump and the inlet of said discharge pump.

7. A control method of a perfusate injection device, applied to a perfusate injection device according to any of claims 1-6, characterized in that the control method comprises:

acquiring a blood pressure value at a target location;

8. The control method of the perfusate injection device according to claim 7, wherein before the acquisition of the blood pressure value at the target position, the control method further comprises:

controlling the transmission pipeline to be filled with perfusate;

and controlling the pump blood flow of the pump blood equipment and the flow of the input pump to be first preset flow or controlling the pump blood flow of the pump blood equipment and the flow of the discharge pump to be second preset flow.

9. The method of controlling a perfusate injection device according to claim 8, wherein said controlling a flow rate of an input pump or a flow rate of an output pump according to said blood pressure value, comprises:

generating a first target flow according to the blood pressure value and a first mapping relation under the condition that the flow of the input pump is the first preset flow, wherein the first mapping relation is the mapping relation between the blood pressure value and the flow of the discharge pump;

and controlling the flow rate of the discharge pump to be the first target flow rate, wherein the first preset flow rate is larger than the first target flow rate.

10. The method of controlling a perfusate injection device according to claim 8, wherein said controlling a flow rate of an input pump or a flow rate of an output pump according to said blood pressure value, comprises:

generating a second target flow according to the blood pressure value and a second mapping relation under the condition that the flow of the discharge pump is the second preset flow, wherein the second mapping relation is the mapping relation between the blood pressure value and the flow of the input pump;

and controlling the flow rate of the input pump to be the second target flow rate, wherein the second preset flow rate is smaller than the second target flow rate.