CN117796743A - Endoscopic probe and endoscopic system - Google Patents
Endoscopic probe and endoscopic system Download PDFInfo
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- 238000003384 imaging method Methods 0.000 claims abstract description 48
- 238000001228 spectrum Methods 0.000 claims abstract description 21
- 238000013461 design Methods 0.000 claims abstract description 3
- 239000013307 optical fiber Substances 0.000 claims description 36
- 230000005284 excitation Effects 0.000 claims description 13
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 10
- 238000002073 fluorescence micrograph Methods 0.000 claims description 8
- 230000005693 optoelectronics Effects 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 6
- 229910021645 metal ion Inorganic materials 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 5
- 238000005253 cladding Methods 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 3
- 238000012285 ultrasound imaging Methods 0.000 claims 1
- 238000011160 research Methods 0.000 abstract description 6
- 238000003745 diagnosis Methods 0.000 abstract description 4
- 238000012014 optical coherence tomography Methods 0.000 description 21
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
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- 229910052761 rare earth metal Inorganic materials 0.000 description 3
- 150000002910 rare earth metals Chemical class 0.000 description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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Abstract
The invention relates to an endoscopic probe and an endoscopic system, wherein the endoscopic probe comprises an endoscopic sheath tube, an imaging module and a detection module, the imaging module is arranged in the endoscopic sheath tube, and the detection module and the endoscopic sheath tube are of an integrated structural design; the imaging module is used for outputting a first optical signal and transmitting the first optical signal to biological tissues for detection imaging so as to acquire images of the biological tissues; the imaging module is also used for outputting a second optical signal and transmitting the second optical signal to the detection module, the detection module is used for detecting a reflection spectrum formed by the second optical signal, and the reflection spectrum is used for detecting physiological parameters of the surrounding environment where the biological tissue is located. The endoscopic probe can not only acquire images of biological tissues, but also detect physiological parameters of surrounding environments where the biological tissues are located at the same time, provides more comprehensive and deep information for medical diagnosis and biological research, and is expected to play an important role in clinical practice and scientific research and improve the accuracy of data and the richness of information.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an endoscopic probe and an endoscopic system.
Background
Miniaturized fiber optic imaging probes, such as optical coherence tomography (Optical Coherence Tomography, OCT) and the like, offer researchers the ability to high resolution endoscopic imaging, and have demonstrated excellent utility in a wide range of biomedical applications. However, the current imaging probe can only acquire structural information or functional information of biological tissue, but cannot detect physiological parameters of the surrounding environment where the biological tissue is located at the same time, so providing an endoscopic probe and an endoscopic system capable of simultaneously acquiring images of the biological tissue and detecting physiological parameters of the surrounding environment where the biological tissue is located is a technical problem to be solved.
Disclosure of Invention
Based on this, it is necessary to provide an endoscopic probe and an endoscopic system capable of simultaneously acquiring an image of a biological tissue and detecting a physiological parameter of the surrounding environment in which the biological tissue is located.
An inner snoop head comprising: the device comprises an endoscopic sheath, an imaging module and a detection module, wherein the imaging module is arranged in the endoscopic sheath, and the detection module and the endoscopic sheath are of an integrated structural design; the imaging module is used for outputting a first optical signal and transmitting the first optical signal to biological tissues for detection imaging so as to acquire images of the biological tissues;
the imaging module is further configured to output a second optical signal, and transmit the second optical signal to the detection module, where the detection module is configured to detect a reflection spectrum formed by the second optical signal, where the reflection spectrum is configured to detect a physiological parameter of an ambient environment where the biological tissue is located, where the physiological parameter includes at least one of a temperature, a pressure, a PH value, a metal ion concentration, and a hydrogen peroxide concentration.
In one embodiment, the first optical signal includes an OCT optical signal for acquiring an OCT image of the biological tissue and a fluorescence excitation signal for acquiring a fluorescence image of the biological tissue;
the second optical signal comprises a PH detection optical signal and a temperature detection optical signal, wherein the PH detection optical signal is used for detecting the PH value of the surrounding environment where the biological tissue is located, and the temperature detection optical signal is used for detecting the temperature of the surrounding environment where the biological tissue is located.
In one embodiment, the imaging module includes a double-clad optical fiber, a coreless optical fiber and a self-focusing lens module, where the double-clad optical fiber is used for outputting the first optical signal and the second optical signal, the coreless optical fiber is used for diverging the first optical signal and the second optical signal output by the double-clad optical fiber, and the self-focusing lens module is used for transmitting, splitting and focusing the composite optical signal output by the coreless optical fiber so as to output each optical signal contained in the first optical signal and the second optical signal.
In one embodiment, the double-clad optical fiber comprises a single-mode fiber core and a multimode inner cladding layer wrapping the outer side of the Shan Moqian core, wherein the single-mode fiber core is used for outputting the OCT optical signals, the multimode inner cladding layer is used for outputting a plurality of optical signals with different wavelengths, and the plurality of optical signals comprise the PH detection optical signals, the temperature detection optical signals and the fluorescence excitation optical signals.
In one embodiment, the self-focusing lens module includes a first self-focusing lens, a second self-focusing lens and a third self-focusing lens sequentially arranged; the detection module comprises a first detection module and a second detection module,
the first optical signal and the second optical signal output by the double-clad optical fiber are diverged by the coreless optical fiber, are incident to the first self-focusing lens for first focusing, then are emitted to the semi-reflection semi-transmission inclined plane of the second self-focusing lens, the OCT optical signal and the fluorescence excitation optical signal are reflected and transmitted to the biological tissue to respectively acquire the OCT image and the fluorescence image of the biological tissue, the PH detection optical signal and the temperature detection optical signal are transmitted to the second self-focusing lens for second divergence and focusing, the PH detection optical signal is emitted to the semi-reflection semi-transmission inclined plane of the third self-focusing lens, the PH detection optical signal is reflected and transmitted to the first detection module to enable the first detection module to form a PH value reflection spectrum based on the PH detection optical signal, and the temperature detection optical signal is transmitted to the third self-focusing lens for third divergence and focusing and finally emitted and transmitted to the second detection module to enable the second detection module to form a PH value reflection spectrum based on the temperature detection optical signal.
In one embodiment, the endoscopic probe further comprises an ultrasonic transducer disposed within the endoscopic sheath, the ultrasonic transducer configured to output an ultrasonic signal and transmit the ultrasonic signal into the biological tissue for ultrasonic imaging.
An endoscopic system, comprising: the driving module and the endoscopic probe are used for driving the endoscopic probe to move.
In one embodiment, the endoscopic system further comprises a scanning light source, a first coupler, a first circulator, a second circulator, a reference arm and a sample arm, wherein an input end of the first coupler is connected with the scanning light source, a first output end of the first coupler is connected with an input end of the first circulator, a first output end of the first circulator is connected with the reference arm, a second output end of the first coupler is connected with an input end of the second circulator, a first output end of the second circulator is connected with the sample arm, a first optical signal output by the scanning light source is split into two beams by the first coupler, one beam of the first optical signal enters the reference arm to generate the reference signal, and the other beam of the first optical signal enters the sample arm to be emitted to the biological tissue for imaging.
In one embodiment, the imaging module includes a double-clad optical fiber, a coreless optical fiber and a self-focusing lens module which are sequentially arranged, the endoscopic system further includes a broadband light source, the sample arm includes a second coupler, a third coupler and a wavelength division multiplexer, the driving module includes an optoelectronic slip ring, a second output end of the first circulator is connected with a first input end of the second coupler, a first output end of the second circulator is connected with a first input end of the wavelength division multiplexer, a second output end of the second circulator is connected with a second input end of the second coupler, the broadband light source is connected with a second input end of the wavelength division multiplexer, an output end of the wavelength division multiplexer is connected with a first input end of the third coupler, a second input end of the third coupler is connected with the self-focusing lens module, and an output end of the third coupler is connected with the optoelectronic slip ring through the double-clad optical fiber.
In one embodiment, the endoscopic system further comprises an ultrasonic pulse transceiver and an amplifier, wherein the ultrasonic pulse transceiver is connected with the input end of the amplifier, and the output end of the amplifier is connected with the photoelectric slip ring.
The utility model provides an endoscopic probe, imaging module is used for outputting first optical signal, and detect formation of image in order to obtain biological tissue with first optical signal transmission to biological tissue, imaging module still is used for outputting the second optical signal, and with second optical signal transmission to detection module, detection module is used for detecting the reflection spectrum that the second optical signal formed, reflection spectrum is used for detecting the physiological parameter of the surrounding environment that biological tissue is located, physiological parameter includes at least one in temperature, pressure, PH value, metal ion concentration and the hydrogen peroxide concentration, consequently, the endoscopic probe of this application not only can acquire biological tissue's image, can also detect the physiological parameter of the surrounding environment that biological tissue is located simultaneously, provide more comprehensive and deep information for medical diagnosis and biological research, be expected to play important role in clinical practice and scientific research, improve the accuracy of data and the richness of information.
Drawings
FIG. 1 is a schematic view of an endoscopic probe according to an embodiment of the present invention;
FIG. 2 is a schematic view of optical transmission of an endoscopic probe according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a semi-reflective semi-transmissive slope of a second and a third self-focusing lens according to an embodiment of the present invention;
fig. 4 is a schematic diagram of an endoscopic system according to an embodiment of the present invention.
Detailed Description
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
As shown in fig. 1, the present application provides an endoscopic probe 100, where the endoscopic probe 100 is used for endoscopic imaging of biological tissue and detection of physiological parameters of an ambient environment where the biological tissue is located, the endoscopic probe 100 includes an endoscopic sheath 120, an imaging module 110 and a detection module 130, the imaging module 110 is disposed in the endoscopic sheath 120, and the detection module 130 and the endoscopic sheath 120 are designed as an integrated structure; the imaging module 110 is configured to output a first optical signal, and transmit the first optical signal to biological tissue for detection imaging to obtain an image of the biological tissue; the imaging module 110 is further configured to output a second optical signal, and transmit the second optical signal to the detection module 130, where the detection module 130 is configured to detect a reflection spectrum formed by the second optical signal, and the reflection spectrum is configured to detect a physiological parameter of an ambient environment where the biological tissue is located, where the physiological parameter includes at least one of a temperature, a pressure, a PH value, a metal ion concentration, and a hydrogen peroxide concentration.
The endoscopic probe 100 provided by the application is used for outputting a first optical signal, transmitting the first optical signal to biological tissues for detection imaging to acquire images of the biological tissues, outputting a second optical signal by the imaging module 110, transmitting the second optical signal to the detection module 130, detecting a reflection spectrum formed by the second optical signal by the detection module 130, and detecting physiological parameters of surrounding environment where the biological tissues are located, wherein the physiological parameters comprise at least one of temperature, pressure, PH value, metal ion concentration and hydrogen peroxide concentration, so that the endoscopic probe 100 not only can acquire images of the biological tissues, but also can detect the physiological parameters of the surrounding environment where the biological tissues are located at the same time, provides more comprehensive and deep information for medical diagnosis and biological research, is expected to play an important role in clinical practice and scientific research, and improves the accuracy of data and the richness of information.
Specifically, the first optical signal includes an OCT optical signal for acquiring an OCT image of the biological tissue and a fluorescence excitation light signal for acquiring a fluorescence image of the biological tissue. The second optical signal comprises a PH detection optical signal and a temperature detection optical signal, the PH detection optical signal is used for detecting the PH value of the surrounding environment where the biological tissue is located, and the temperature detection optical signal is used for detecting the temperature of the surrounding environment where the biological tissue is located.
As shown in fig. 1, the imaging module 110 includes a double-clad optical fiber 111, a coreless optical fiber 112 and a self-focusing lens module 113, which are sequentially arranged, the double-clad optical fiber 111 is used for outputting a first optical signal and a second optical signal, the coreless optical fiber 112 is used for diverging the first optical signal and the second optical signal output by the double-clad optical fiber 111, and the self-focusing lens module 113 is used for transmitting, splitting and focusing the composite optical signal output by the coreless optical fiber 112 so as to output each optical signal contained in the first optical signal and the second optical signal.
Specifically, the double-clad optical fiber 111, the coreless optical fiber 112 and the self-focusing lens module 113 are sequentially arranged from the tail end to the head end of the endoscope sheath 120, wherein the head end of the endoscope sheath 120 is a closed end, and the tail end of the endoscope sheath 120 is an open end, so that the imaging module 110, the detection module 130 and other components can be installed into the endoscope sheath 120 through the tail end opening of the endoscope sheath 120.
The double-clad optical fiber 111 includes a single-mode core for outputting an OCT optical signal and a multimode inner cladding for outputting a plurality of optical signals having different wavelengths, including a PH detection optical signal, a temperature detection optical signal, and a fluorescence excitation optical signal, which are wrapped outside the single-mode core.
As shown in fig. 1 and 2, the self-focusing lens module 113 includes a first self-focusing lens 114, a second self-focusing lens 115, and a third self-focusing lens 116, which are sequentially disposed; the detection module 130 includes a first detection module 131 and a second detection module 132, and specifically, the first self-focusing lens 114, the second self-focusing lens 115, and the third self-focusing lens 116 may be green lenses, and the first self-focusing lens 114, the second self-focusing lens 115, and the third self-focusing lens 116 are sequentially disposed from the tail end to the head end of the endoscopic sheath 120;
the first optical signal and the second optical signal output by the double-clad optical fiber 111 are diverged by the coreless optical fiber 112, are incident to the first self-focusing lens 114 for first focusing, then are emitted to the semi-reflective semi-transmissive inclined plane of the second self-focusing lens 115, reflect and transmit the OCT optical signal and the fluorescence excitation optical signal to biological tissues to obtain OCT images and fluorescence images of the biological tissues respectively, transmit the PH detection optical signal and the temperature detection optical signal to the second self-focusing lens 115 for second divergence and focusing, emit to the semi-reflective semi-transmissive inclined plane of the third self-focusing lens 116, reflect and transmit the PH detection optical signal to the first detection module 131, so that the first detection module 131 forms a PH value reflection spectrum based on the PH detection optical signal, transmit the temperature detection optical signal to the third self-focusing lens 116 for third divergence and focusing, and finally emit and transmit to the second detection module 132, so that the second detection module 132 forms a temperature reflection spectrum based on the temperature detection optical signal.
The OCT (optical coherence tomography) has high sensitivity and high resolution as a powerful biomedical imaging method, and can be reconstructed into a high-resolution image with a chromatographic structure according to the low coherence interference principle to detect whether a specific lesion exists in an imaging region of a biological tissue during in-vivo detection diagnosis and laser surgery of other biological tissues such as human micro-blood vessels, and the fluorescence image is excited to generate fluorescence emission by exciting a fluorescence detector (for example, fluorescent dye) injected into the biological tissue so as to detect whether the specific lesion exists in the region of the biological tissue.
The PH detection light signal reflected by the third autofocus lens 116 is emitted to the first detection module 131 vertically, where the first detection module 131 may be a PH sensing film disposed at the inner side of the front end of the endoscopic sheath 120, and the PH film may be coated at the inner side of the front end of the endoscopic sheath 120 by splicing or coating, when the PH value of the surrounding environment where the biological tissue is located is abnormal, the property of the PH sensing film may be changed, so that the reflection spectrum thereof is shifted, and the PH value of the surrounding environment where the current biological tissue is located can be calculated by detecting the reflection spectrum thereof.
The temperature detection light signal emitted from the third self-focusing lens 116 is emitted to the second detection module 132, where the second detection module 132 may be a rare earth metal block disposed inside the front end of the endoscopic sheath 120, and the rare earth metal block is a temperature sensitive device, and the temperature value of the surrounding environment where the current biological tissue is located can be calculated by detecting the reflection spectrum thereof.
It should be noted that, the PH sensing film and the rare earth metal block are designed to be integrated with the endoscope sheath 120, which is beneficial to not being interfered by the imaging environment inside the endoscope sheath 120, and being capable of contacting with the surrounding environment where the biological tissue is located more directly, thereby improving the accuracy of detecting the physiological parameters.
As shown in fig. 3, in particular, the semi-reflective semi-transmissive slopes of the second self-focusing lens 115 and the third self-focusing lens 116 include a slope base 117, and an antireflection film 118 and a reflection film 119 sequentially stacked on the slope base 117, and the reflection film 119 and the antireflection film 118 may be designed to reflect light signals of a specific wavelength and transmit light signals of a specific wavelength, respectively. The antireflection film 118 and the reflection film 119 are each disposed in parallel with the inclined base surface 117, that is, the inclination angles of the antireflection film 118 and the reflection film 119 are each identical to the inclination angle of the inclined base surface 117.
As shown in fig. 1, the endoscopic probe 100 optionally further includes an ultrasonic transducer 140, the ultrasonic transducer 140 is disposed in the endoscopic sheath 120, the ultrasonic transducer 140 is disposed in parallel with the imaging module 110, and the ultrasonic transducer 140 is configured to output an ultrasonic signal and transmit the ultrasonic signal to the biological tissue for ultrasonic imaging to obtain an ultrasonic image of the biological tissue. By means of the arrangement, the endoscopic probe 100 can acquire OCT images, fluorescent images and ultrasonic images so as to perform multi-mode imaging on biological tissues, analyze the positions of areas to be imaged in the biological tissues, evaluate the positions and the sizes of focuses more accurately and provide more accurate basis for subsequent treatment schemes. It will be appreciated that the endoscopic probe 100 also includes a photoacoustic imaging module or other imaging module disposed within the endoscopic sheath 120 for more accurate assessment of the location and size of the lesion.
The endoscopic probe 100 further includes a high frequency coaxial line 150, the high frequency coaxial line 150 being disposed within the endoscopic sheath 120 and connected to the ultrasound transducer 140, the high frequency coaxial line 150 being configured to transmit ultrasound signals.
The endoscopic probe 100 further comprises a metal capillary 160, the metal capillary 160 is disposed in the endoscopic sheath 120, the ultrasonic transducer 140, the first self-focusing lens 114, the second self-focusing lens 115 and the third self-focusing lens 116 are disposed in the metal capillary 160, and the metal capillary 160 is used for protecting the ultrasonic transducer 140, the first self-focusing lens 114, the second self-focusing lens 115 and the third self-focusing lens 116.
The endoscopic probe 100 further includes a torque spring 170, the torque spring 170 is disposed in the endoscopic sheath 120, the torque spring 170 is abutted to one side of the metal capillary 160, and the torque spring 170 is used for maintaining stability of the inspection probe when the inspection probe moves. Specifically, both the double-clad optical fiber 111 and the high-frequency coaxial wire 150 are wrapped in a torsion spring 170.
As shown in fig. 4, the present application further provides an endoscopic system, which includes a driving module 200 and an endoscopic probe 100, where the driving module 200 is used to drive the endoscopic probe 100 to move. The drive module 200 includes a rotation and retraction motor 210, the rotation and retraction motor 210 being configured to rotate and/or retract the endoscopic probe 100.
The endoscopic system includes a scanning light source 300 for generating a first optical signal and transmitting the first optical signal to the imaging module 110, and a broadband light source 400 for generating a second optical signal and transmitting the second optical signal to the imaging module 110. Specifically, the scanning light source 300 is used to generate OCT light signals, and the broadband light source 400 is used to generate PH detection light signals and temperature detection light signals.
As shown in fig. 4, the endoscopic system further includes a first coupler 310, a first circulator 320, a second circulator 330, a reference arm 340 and a sample arm 350, wherein an input end of the first coupler 310 is connected to the scanning light source 300, a first output end of the first coupler 310 is connected to the input end of the first circulator 320, a first output end of the first circulator 320 is connected to the reference arm 340, a second output end of the first coupler 310 is connected to an input end of the second circulator 330, a first output end of the second circulator 330 is connected to the sample arm 350, a first optical signal output by the scanning light source 300 is split into two beams by the first coupler 310, one beam of the first optical signal enters the reference arm 340 to generate the reference signal, and the other beam of the first optical signal enters the sample arm 350 to be emitted to biological tissues for imaging.
Specifically, the reference arm 340 includes a lens 341 and a mirror 342, the first output end of the first circulator 320 is connected to the lens 341, and the lens 341 is configured to perform beam expansion collimation processing on the first optical signal; the mirror 342 is used for reflecting the first optical signal transmitted through the lens 341. It is noted that the first optical signal comprises an OCT optical signal.
As shown in fig. 4, the sample arm 350 includes a second coupler 351, a third coupler 352 and a wavelength division multiplexer 353, the driving module 200 includes an opto-electronic slip ring, a second output end of the first circulator 320 is connected to a first input end of the second coupler 351, a first output end of the second circulator 330 is connected to a first input end of the wavelength division multiplexer 353, a second output end of the second circulator 330 is connected to a second input end of the second coupler 351, the broadband light source 400 is connected to a second input end of the wavelength division multiplexer 353, an output end of the wavelength division multiplexer 353 is connected to a first input end of the third coupler 352, a second input end of the third coupler 352 is connected to the opto-electronic slip ring module 113, and an output end of the third coupler 352 is connected to the opto-electronic slip ring through the double-clad optical fiber 111.
The optical signals (OCT optical signal, PH detection optical signal and temperature detection optical signal) of the sample arm 350 are coupled to the single-mode optical fiber by the wavelength division multiplexer 353, and then coupled to the double-clad optical fiber 111 by the third coupler 352, and the optical signals (fluorescence excitation optical signal, PH detection optical signal and temperature detection optical signal) with different wavelengths are transmitted to the opto-electronic slip ring, and when the optical signals with different wavelengths return, the fluorescence excitation optical signal is separated from the various physiological index spectrum signals (PH detection optical signal and temperature detection optical signal) by the third coupler 352, and then the optical signals with different wavelengths are respectively incident into the detectors (fluorescence detector 133, first detection module 131 and second detection module 132) with different wavelengths by the self-focusing lens 341 module 113, so that the fluorescence image of the biological tissue and the physiological parameters (PH value and temperature) of the surrounding environment where the biological tissue is located can be obtained, and the OCT signal is decoupled to the second annular ring 330 by the wavelength division multiplexer 353 again, and the OCT signal is then obtained by the interference detection of the optical signal of the sample arm 350 with the second coupler 351.
As shown in fig. 4, the endoscopic system further includes an ultrasonic pulse transceiver 500 and an amplifier 600, the ultrasonic pulse transceiver 500 is connected with an input end of the amplifier 600, an output end of the amplifier 600 is connected with the photoelectric slip ring, the ultrasonic pulse transceiver 500 generates excitation pulses, the excitation pulses are amplified by the amplifier 600 and coupled into the photoelectric slip ring, and the returned ultrasonic signals are input into the ultrasonic pulse transceiver 500 to be collected and filtered, so that effective ultrasonic signals can be obtained.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The foregoing examples only represent preferred embodiments of the present invention, which are described in more detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. An endoscopic probe, comprising: the device comprises an endoscopic sheath, an imaging module and a detection module, wherein the imaging module is arranged in the endoscopic sheath, and the detection module and the endoscopic sheath are of an integrated structural design;
the imaging module is used for outputting a first optical signal and transmitting the first optical signal to biological tissues for detection imaging so as to acquire images of the biological tissues;
the imaging module is further configured to output a second optical signal, and transmit the second optical signal to the detection module, where the detection module is configured to detect a reflection spectrum formed by the second optical signal, where the reflection spectrum is configured to detect a physiological parameter of an ambient environment where the biological tissue is located, where the physiological parameter includes at least one of a temperature, a pressure, a PH value, a metal ion concentration, and a hydrogen peroxide concentration.
2. The endoscopic probe according to claim 1, wherein said first optical signal comprises an OCT optical signal for acquiring an OCT image of said biological tissue and a fluorescence excitation signal for acquiring a fluorescence image of said biological tissue;
the second optical signal comprises a PH detection optical signal and a temperature detection optical signal, wherein the PH detection optical signal is used for detecting the PH value of the surrounding environment where the biological tissue is located, and the temperature detection optical signal is used for detecting the temperature of the surrounding environment where the biological tissue is located.
3. The endoscopic probe according to claim 2, wherein the imaging module comprises a double-clad optical fiber, a coreless optical fiber and a self-focusing lens module, which are sequentially arranged, the double-clad optical fiber is used for outputting the first optical signal and the second optical signal, the coreless optical fiber is used for diverging the first optical signal and the second optical signal output by the double-clad optical fiber, and the self-focusing lens module is used for transmitting, splitting and focusing the composite optical signal output by the coreless optical fiber so as to output each optical signal contained in the first optical signal and the second optical signal.
4. The endoscopic probe according to claim 3, wherein said double-clad optical fiber comprises a single-mode core for outputting said OCT optical signal and a multimode inner cladding wrapped outside said Shan Moqian core for outputting a plurality of optical signals having different wavelengths, a plurality of said optical signals including said PH-detecting optical signal, said temperature-detecting optical signal and said fluorescence excitation optical signal.
5. The endoscopic probe according to claim 3, wherein the self-focusing lens module comprises a first self-focusing lens, a second self-focusing lens and a third self-focusing lens arranged in sequence; the detection module comprises a first detection module and a second detection module,
the first optical signal and the second optical signal output by the double-clad optical fiber are diverged by the coreless optical fiber, are incident to the first self-focusing lens for first focusing, then are emitted to the semi-reflection semi-transmission inclined plane of the second self-focusing lens, the OCT optical signal and the fluorescence excitation optical signal are reflected and transmitted to the biological tissue to respectively acquire the OCT image and the fluorescence image of the biological tissue, the PH detection optical signal and the temperature detection optical signal are transmitted to the second self-focusing lens for second divergence and focusing, the PH detection optical signal is emitted to the semi-reflection semi-transmission inclined plane of the third self-focusing lens, the PH detection optical signal is reflected and transmitted to the first detection module to enable the first detection module to form a PH value reflection spectrum based on the PH detection optical signal, and the temperature detection optical signal is transmitted to the third self-focusing lens for third divergence and focusing and finally emitted and transmitted to the second detection module to enable the second detection module to form a PH value reflection spectrum based on the temperature detection optical signal.
6. The endoscopic probe according to claim 5, further comprising an ultrasound transducer disposed within the endoscopic sheath for outputting ultrasound signals and transmitting the ultrasound signals into the biological tissue for ultrasound imaging.
7. An endoscopic system, comprising: a drive module and an endoscopic probe according to any one of claims 1 to 6, the drive module being arranged to move the endoscopic probe.
8. The endoscopic system of claim 7, further comprising a scanning light source, a first coupler, a first circulator, a second circulator, a reference arm, and a sample arm, wherein an input end of the first coupler is connected to the scanning light source, a first output end of the first coupler is connected to the input end of the first circulator, a first output end of the first circulator is connected to the reference arm, a second output end of the first coupler is connected to the input end of the second circulator, a first output end of the second circulator is connected to the sample arm, and a first optical signal output by the scanning light source is split into two beams by the first coupler, wherein one beam of the first optical signal enters the reference arm to generate the reference signal, and the other beam of the first optical signal enters the sample arm to be emitted to the biological tissue for imaging.
9. The endoscopic system of claim 8, wherein the imaging module comprises a double-clad fiber, a coreless fiber, and a self-focusing lens module, which are sequentially arranged, the endoscopic system further comprises a broadband light source, the sample arm comprises a second coupler, a third coupler, and a wavelength division multiplexer, the driving module comprises an optoelectrical slip ring, the second output end of the first circulator is connected with the first input end of the second coupler, the first output end of the second circulator is connected with the first input end of the wavelength division multiplexer, the second output end of the second circulator is connected with the second input end of the second coupler, the broadband light source is connected with the second input end of the wavelength division multiplexer, the output end of the wavelength division multiplexer is connected with the first input end of the third coupler, the second input end of the third coupler is connected with the self-focusing lens module, and the output end of the third coupler is connected with the optoelectrical slip ring through the double-clad fiber.
10. The endoscopic system of claim 9, further comprising an ultrasonic pulse transceiver and an amplifier, wherein the ultrasonic pulse transceiver is coupled to an input of the amplifier, and wherein an output of the amplifier is coupled to the opto-electronic slip ring.
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