CN117731970A - Method and system for generating focused ultrasonic beauty treatment dosage delivery scheme based on image data - Google Patents
Method and system for generating focused ultrasonic beauty treatment dosage delivery scheme based on image data Download PDFInfo
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Abstract
The invention discloses a method and a system for generating a focused ultrasound beauty treatment dosage delivery scheme based on image data, which relate to the technical field of high-intensity focused ultrasound facial rejuvenation. The visualization system ensures that the device and skin are properly attached and remain at the proper depth during treatment, preventing false targeting of other tissues, such as bones, nerves, etc., minimizing unnecessary pain and side effects. An experienced operator may select a particular depth and energy level for the patient based on the visualization data to achieve personalized treatment; solves the problem that the prior domestic focused ultrasound beauty treatment can not realize standard safety and effectiveness treatment.
Description
Technical Field
The invention relates to the technical field of high-intensity focused ultrasound facial rejuvenation, in particular to a method and a system for generating a focused ultrasound cosmetic dose delivery scheme based on image data.
Background
Focused ultrasound (Focused Ultrasound, FU) is an emerging minimally invasive surgical disease treatment technique, currently clinically FU is mainly used for treatment of deep tissue diseases, such as ablation of uterine fibroids, but in recent years FU has also shown significant value in superficial skin cosmetics with the development of ultrasound and related transducer technologies. Focused ultrasound cosmetology is a high intensity ultrasonic wave generated by a high frequency focused ultrasonic transducer developed specifically for superficial tissue treatment, focused in a superficial tissue layer and generated to a size of about 1mm 3 Is a thermal injury region of the collagen fibers denatured after heating, and contracts, causing skin tightening. At the same time, the thermal injury can cause healing reaction locally to generate new collagen and elastin, thereby achieving the effects of reversing skin aging, tightening skin and improving wrinkles. Focused ultrasound cosmetology can achieve the ideal state that the energy temperature acting on the skin surface is relatively low and the temperature reaches the highest at the treatment point. Meanwhile, the highest subcutaneous temperature can reach 60-75 ℃, and the temperature has the best effect on collagen remodeling. Some treatment modes include laser and radio frequency which belong to divergent energy, the treatment temperature gradually decreases along with the increase of the skin thickness, the treatment point is required to reach the optimal temperature for collagen remodeling, the temperature of the epidermis is far higher than 60 ℃ and exceeds the maximum threshold value which can be born by a human body, and the optimal temperature for the collagen remodeling of a treatment layer cannot be truly realized.
The depth of action of the focused ultrasonic beauty transducer on the market at present is 1.5mm, 2.0mm, 3.0mm and 4.5mm, wherein 1.5mm aims at shallow texture treatment; 2.0mm acts on the dermis layer, stimulates the collagen to continuously regenerate and lightens deep wrinkles; 3.0mm acts on the superficial fat layer, tightening the skin and reducing adipocytes; 4.5mm acts on the superficial tendon nervous system (superficial musculoaponeurotic system, SMAS), pulling the basal to achieve a tight lift.
Because the sound propagation of high-frequency ultrasound in superficial multilayer complex tissues is complex, the dosage scheme of focused ultrasound treatment standardized for focused ultrasound cosmetology is still lacking, and the current ultrasound cosmetology treatment is mainly based on the experience of doctors and cannot guarantee the safety of treatment. The effect of the same energy input is completely different for skin of different thickness. If the energy is too small, the effective treatment effect cannot be achieved on the fat-rich area, and if the energy is high, the adverse reaction is probably caused greatly on the skin-thinner area. According to the facial anatomy, the deep and shallow tissue structure of the human face is very complex, the subcutaneous fat layers have uneven thickness and different tissue densities, and the subcutaneous tissue conditions of the same parts of different patients also have differences. Therefore, the establishment of personalized treatment schemes according to different patients is an important premise for guaranteeing treatment safety, and the more accurate the treatment scheme is, the lower the risk is. And no visualization system is equipped in the domestic focused ultrasound beauty instrument at present.
Disclosure of Invention
Therefore, the invention aims to provide a method and a system for generating a focused ultrasound cosmetic dose delivery scheme based on image data, wherein the method ensures the accuracy of a treatment process by performing feedback through visualization.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the invention provides a method for generating a focused ultrasound beauty treatment dosage plan based on image data, which comprises the following steps:
acquiring image data of a treatment area; the image data comprises any one or more of epidermis, shallow dermis layer, deep dermis layer, fat layer and SMAS layer depth data;
constructing a biological tissue layer model according to the image data;
determining parameters for selecting the ultrasonic transducer according to the image data;
constructing a theoretical simulation model according to the biological tissue layer model and the ultrasonic transducer, wherein the theoretical simulation model is used for simulating sound field thermal field data in the focused ultrasonic treatment process; analyzing and processing according to the sound field thermal field data to obtain a focused ultrasound dose delivery scheme;
the focused ultrasound dosing regimen is presented on a visualization system disposed on the ultrasound transducer.
Further, the theoretical simulation model is constructed according to the following steps:
acquiring parameters for constructing the transducer;
constructing each biological tissue layer model according to the image data;
acquiring acoustic parameters and thermal parameters of each biological tissue layer model;
performing simulation calculation according to parameters of the transducer and the biological tissue layer model to obtain a sound field result and a thermal field result;
and calculating according to the obtained sound field result and the obtained thermal field result to obtain any one or more of sound pressure distribution, temperature distribution, damage distribution and thermal dose distribution of different areas in the treatment process.
Further, the focused ultrasound dosing value in the focused ultrasound dosing scheme is calculated according to the following formula:
wherein TD is the thermal dose;
t is the tissue temperature; t represents time;
r represents a numerical value, r=0.25 when T is equal to or less than 43 ℃; when T > 43 ℃, r=0.5.
Further, the image data includes B-ultrasonic imaging data or/and photoacoustic imaging data.
The invention provides a system for generating a focused ultrasound beauty treatment dosage plan based on image data, which comprises a theoretical simulation model, a treatment device, a treatment parameter setting module and an image monitoring module;
the theoretical simulation model is used for simulating sound field thermal field data in the focused ultrasound treatment process; analyzing and processing according to the sound field thermal field data to obtain a focused ultrasound dose delivery scheme;
the treatment device is used for treating the ultrasonic energy output from the treatment area and collecting image data of the treatment process;
the treatment parameter setting module is used for setting the type of the treatment probe and the parameters of the treatment process;
the image monitoring module is used for storing the acquired image data and outputting the dose delivery and curative effect evaluation results.
Further, the dose administration and the curative effect evaluation result are carried out according to the following modes:
judging whether a lump type strong echo appears in a subcutaneous epidermis region in the image data, if the strong echo phenomenon and the gray level change do not appear, the method indicates that the epidermis is not damaged in the treatment process, and the safety treatment is realized;
judging whether a subcutaneous treatment area in the image data has a massive strong echo, and if the strong echo phenomenon and the gray level change occur, indicating that the treatment area is effectively damaged, and treating effectively.
Further, the focused ultrasound dosing value in the focused ultrasound dosing scheme is calculated according to the following formula:
wherein TD is the thermal dose;
t is the tissue temperature; t represents time;
r represents a numerical value, r=0.25 when T is equal to or less than 43 ℃; when T > 43 ℃, r=0.5.
Further, the theoretical simulation model comprises a transducer module, a biological tissue module, a data collection module, a data processing module and a data feedback module;
the transducer module is used for constructing the geometric structure, frequency and output parameters of the transducer;
the biological tissue module is used for constructing each biological tissue layer model based on the image data;
the data collection module is used for endowing each constructed biological tissue layer model with corresponding acoustic parameters and thermal parameters, wherein the acoustic parameters comprise any one or more of sound velocity, density, attenuation coefficient and nonlinear coefficient; the thermal parameters include tissue specific heat capacity or/and thermal conductivity;
the data processing module is used for performing simulation calculation to obtain a sound field result and a thermal field result after the transducer module, the biological tissue module and the data collection module are all arranged;
the data feedback module is used for performing post-processing on the data calculated by the data processing module to obtain any one or more of sound pressure distribution, temperature distribution, damage distribution and thermal dose distribution of different areas in the treatment process.
Further, the image monitoring module comprises a preoperative module, an intraoperative module and a postoperative module;
the preoperative module is used for screening transducers with different depths required by the patient to treat different areas through image data;
the intraoperative module is used for monitoring sound pressure distribution, temperature distribution and damage distribution of different areas in the treatment process through image data;
the postoperative module is used for evaluating the treatment effect by the image data.
The invention has the beneficial effects that:
according to the method and the system for generating the focused ultrasound beauty treatment dosage plan based on the image data, which are provided by the invention, the system builds a theoretical simulation model and a three-dimensional reconstruction model, and the deep facial tissue condition in the ultrasonic operation process is fed back to an operator through a visualization system, so that the doctor and a patient can track the treatment condition in real time, and the better determination of the treatment plan is facilitated. The transducer integrates two probes, namely a B ultrasonic imaging probe and a photoacoustic imaging probe, and the visualization system can ensure that the equipment and the skin are properly attached, and the proper depth is kept during treatment, so that other tissues such as bones, nerves and the like are prevented from being mistakenly targeted, and unnecessary pain and side effects are minimized. An experienced operator may select a particular depth and energy level for the patient based on the visualization data to achieve personalized treatment; solves the problem that the prior domestic focused ultrasound beauty treatment can not realize standard safety and effectiveness treatment.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objects and other advantages of the invention may be realized and obtained by means of the instrumentalities and combinations particularly pointed out in the specification.
Drawings
In order to make the objects, technical solutions and advantageous effects of the present invention more clear, the present invention provides the following drawings for description:
fig. 1 is a block diagram of a focused ultrasound cosmetic treatment system.
Fig. 2 is a schematic diagram of an imaging probe structure.
Fig. 3 is an image monitoring module.
Fig. 4 is a flowchart of ultrasound cosmetic transducer selection.
Fig. 5 is a schematic diagram of the functional constitution of the intra-operative module.
In the figure, 1 denotes a handle, 2 denotes an ultrasonic transducer, 3 denotes an imaging probe, 4 denotes a matching layer, 5 denotes a backing layer, 6 denotes a photoacoustic imaging integrated circuit, and 7 denotes a B-ultrasonic imaging integrated circuit.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and specific examples, which are not intended to limit the invention, so that those skilled in the art may better understand the invention and practice it.
As shown in fig. 1, fig. 1 is a module of a focused ultrasound beauty treatment system, and the method for generating a focused ultrasound beauty dosage delivery scheme based on image data provided in this embodiment includes the following steps:
acquiring image data of a treatment area; the image data comprise epidermis, shallow dermis layer, deep dermis layer, fat layer and SMAS layer depth data;
constructing a biological tissue layer model according to the image data;
determining parameters for selecting the ultrasonic transducer according to the image data; the transducer parameters include geometry, frequency, and output parameters;
constructing a theoretical simulation model according to the biological tissue layer model and the ultrasonic transducer, wherein the theoretical simulation model is used for simulating sound field thermal field data in the focused ultrasonic treatment process; and analyzing and processing according to the sound field thermal field data to obtain a focused ultrasound dose delivery scheme.
The focused ultrasound dosing scheme generated in this embodiment is fed back in real time through a visualization system provided on the ultrasound transducer.
The method also comprises the following steps:
constructing a three-dimensional model according to the image data to obtain a three-dimensional reconstruction model, wherein the three-dimensional reconstruction model is used for displaying a three-dimensional model of a biological tissue layer of a treatment area, and establishing an association relation between the biological tissue layer in the three-dimensional reconstruction model and a biological tissue layer in a theoretical simulation model; so that doctors and patients can track the treatment condition in real time;
the focused ultrasound dosing regimen in this embodiment refers to the dose selected during the course of treatment.
The theoretical simulation model is constructed according to the following steps:
acquiring parameters for constructing the transducer; the transducer parameters include geometry, frequency, and output parameters;
constructing each biological tissue layer model according to the image data;
acquiring acoustic parameters and thermal parameters of each biological tissue layer model, wherein the acoustic parameters comprise any one or more of sound velocity, density, attenuation coefficient and nonlinear coefficient; the thermal parameters include tissue specific heat capacity or/and thermal conductivity;
performing simulation calculation according to parameters of the transducer and the biological tissue layer model to obtain a sound field result and a thermal field result;
and calculating according to the obtained sound field result and the obtained thermal field result to obtain any one or more of sound pressure distribution, temperature distribution, damage distribution and thermal dose distribution of different areas in the treatment process.
The biological tissue layer model in the present embodiment includes models of epidermis, dermis, subcutaneous fat, muscle, and the like, and the theoretical simulation model is used to simulate acoustic energy distribution, temperature distribution, damage distribution, thermal energy distribution of the treatment region.
The thermal dose distribution in this embodiment is obtained by calculating the dose delivery value of the focused ultrasound, which is calculated according to the following formula:
where TD is the thermal dose and T is the tissue temperature; t represents time;
r represents a numerical value; when T is less than or equal to 43 ℃, r=0.25; when T > 43 ℃, r=0.5;
the thermal dose formula is equivalent to the treatment time of thermal therapy at 43 ℃; i.e. when the thermal dose reaches an equivalent time of 240 minutes, the tissue can reach coagulative necrosis; necrosis in the tissue occurs when the thermal dose exceeds 240 minutes;
in HIFU treatment, necrosis of tissue immediately occurs at 57 ℃ for 1s or at 60 ℃ for 0.1s, and can be used for judging thermal injury of tissue under HIFU irradiation.
The system for generating the focused ultrasound beauty treatment dosage plan based on the image data comprises a theoretical simulation model, a treatment device, a treatment parameter setting module and an image monitoring module;
the theoretical simulation model is used for simulating sound field thermal field data in the focused ultrasound treatment process; analyzing and processing according to the sound field thermal field data to obtain a focused ultrasound dose delivery scheme;
the treatment device is used for treating the ultrasonic energy output from the treatment area and collecting image data of the treatment process; the main functions are that the face skin of the customer is contacted to collect high-frequency B ultrasonic images and photoacoustic imaging data and output energy for treatment;
the treatment parameter setting module is used for setting the type of the treatment probe and the parameters of the treatment process; the treatment process parameters comprise treatment point spacing, treatment line length, treatment power, treatment time and a treatment button; wherein, the model of the therapeutic probe, the distance between the therapeutic points, the length of the therapeutic line, the therapeutic power and the therapeutic time setting can be displayed, and a therapeutic button can be started;
the image monitoring module is used for storing the acquired image data and outputting the dose delivery and curative effect evaluation results; storing the acquired high-frequency B-ultrasonic imaging and photoacoustic imaging image data, and realizing intelligent dose delivery and curative effect evaluation based on the image data; when the subcutaneous epidermis area in the B ultrasonic image has the massive strong echo, if the strong echo phenomenon and the gray level change do not occur, the treatment process shows that the epidermis is not damaged, and the safety treatment is realized; when the subcutaneous treatment area in the B ultrasonic image has the massive strong echo, if the strong echo phenomenon and the gray level change occur, the effective damage of the treatment area is indicated, and the effective treatment is performed;
the theoretical simulation model provided by the embodiment comprises a transducer module, a biological organization module, a data collection module, a data processing module and a data feedback module;
the transducer module is used for constructing parameters such as the geometric structure, the frequency, the output power, the irradiation time and the like of the transducer;
the biological tissue module is used for constructing personalized biological tissue layer models based on B-ultrasonic images or photoacoustic imaging;
the data collection module is used for endowing each constructed biological tissue layer with corresponding acoustic parameters and thermal parameters, wherein the acoustic parameters comprise sound velocity, density, attenuation coefficient and nonlinear coefficient, and the thermal parameters comprise tissue specific heat capacity and thermal conductivity;
the data processing module is used for processing the simulation model after the transducer module, the biological tissue module and the data collection module are all arranged, and calculating an acoustic field result and a thermal field result;
the data feedback module is used for performing post-processing on the data calculated by the data processing module, and presenting sound pressure distribution, temperature distribution, damage distribution and thermal dose distribution of different areas in the treatment process for doctors and patients;
the focused ultrasound dose delivery based on B-ultrasonic imaging and photoacoustic imaging in the embodiment can be used in the focused ultrasound cosmetic surgery process.
Fig. 1 is a schematic diagram of a therapeutic apparatus, where the therapeutic apparatus includes a therapeutic handle, an ultrasonic transducer and an imaging probe, and the handle is provided with a switch, when the switch is pressed, the ultrasonic transducer is started to work, the imaging probe acquires a B-ultrasonic image and a photoacoustic image, and performs movie and television monitoring, and simultaneously, an ultrasonic signal transmitting module transmits an ultrasonic signal to a target, and performs ultrasonic dose delivery.
The treatment parameter setting panel is used for displaying output data and parameters to be set in the treatment parameter setting module; the monitoring panel is used for displaying output data and parameters to be set in the image monitoring module.
The treatment device in the embodiment is an ultrasonic transducer, and the ultrasonic transducer comprises a main body, an ultrasonic transmitting module, an ultrasonic signal receiving module and an imaging probe, wherein the ultrasonic transmitting module, the ultrasonic signal receiving module and the imaging probe are arranged on the main body; the imaging probe comprises a B ultrasonic imaging probe and a photoacoustic imaging probe;
the ultrasonic transmitting module is used for transmitting ultrasonic signals to a target;
the ultrasonic signal receiving module is used for receiving ultrasonic signals reflected from a target;
the B ultrasonic imaging probe is used for collecting ultrasonic signal imaging data and transmitting the ultrasonic signal imaging data to the image monitoring module;
the photoacoustic imaging probe is used for collecting acoustic wave signals reflected from a target and transmitting the acoustic wave signals to the image monitoring module;
as shown in fig. 2, fig. 2 is a schematic structural diagram of an imaging probe, a B-mode ultrasonic imaging probe of the imaging probe is arranged on a main body, and a matching layer and a backing layer are sequentially arranged on the main body and the B-mode ultrasonic imaging probe; the B ultrasonic imaging probe is arranged at one side of the ultrasonic emission module; the photoacoustic imaging probe of the imaging probe is arranged on the main body, and a matching layer and a backing layer are sequentially arranged on the main body and the photoacoustic imaging probe; the photoacoustic imaging probe is arranged on the other side of the ultrasonic transmitting module; the acoustic impedance of the matching layer in this embodiment is between the acoustic impedance of the wafer and the acoustic impedance of the body tissue so that sound waves can propagate efficiently between the layers of material. The backing layer is used for absorbing the sound energy radiated by the piezoelectric element to the inside of the probe due to vibration, preventing the sound energy from being reflected and transmitted to the piezoelectric element to cause interference, the data acquired by the B-ultrasonic imaging probe are transmitted to the image monitoring module through the B-ultrasonic imaging integrated circuit, and the data acquired by the photoacoustic imaging probe are transmitted to the image monitoring module through the photoacoustic imaging integrated circuit.
As shown in fig. 3, fig. 3 is an image monitoring module, where the image monitoring module includes a preoperative module, an intra-operative module, and a post-operative module;
the preoperative module is used for screening transducers with different depths required by the patient for treating different areas through B-ultrasonic imaging;
the intraoperative module is used for monitoring sound pressure distribution, temperature distribution and damage distribution of different areas in the treatment process through B ultrasonic imaging and photoacoustic imaging;
the postoperative module is used for evaluating the treatment effect through B ultrasonic imaging.
The preoperative module provided by the embodiment can select a transducer based on the B-ultrasonic image; the intra-operative module can realize monitoring based on the combination of B ultrasonic imaging and photoacoustic imaging and theoretical simulation, and can present data of sound field, temperature field and damage distribution in real time so as to realize intelligent dosage delivery; the postoperative module can realize curative effect evaluation based on the B-ultrasonic image.
The preoperative module in this embodiment collects thickness data of epidermis, shallow dermis, deep dermis, fat, SMAS layers of the treatment region according to the B-ultrasound image data to select a transducer of appropriate treatment depth parameters for the patient from the existing transducers.
As shown in fig. 4, fig. 4 is a flowchart of ultrasonic beauty transducer selection, and the ultrasonic transducer selection process for beauty is as follows:
the high-frequency B ultrasonic probe contacts the skin of the treatment area of the patient, and image data of the treatment area of the patient are collected; the image data comprise epidermis, shallow dermis layer, deep dermis layer, fat layer and SMAS layer depth data;
judging whether the thickness of the target treatment area is close to the depth of the treatment probe, if not, replacing the probe closest to the depth of the target treatment area;
if yes, the probe is selected, a treatment scheme is formulated, a starting button is clicked, and treatment is started;
the repeat cycle is returned to when the next zone treatment is entered.
Each ultrasonic beauty transducer in the embodiment has basic treatment parameter settings including treatment point intervals, treatment line lengths, treatment power and treatment time settings of different treatment areas, and can basically realize the safety and effectiveness of treatment without considering personal differences.
The intelligent dosage delivery and curative effect evaluation aiming at individuals can be realized by combining the intra-operation module and the post-operation module.
As shown in fig. 5, fig. 5 is a schematic diagram of each function of an intra-operation module, and the intra-operation module in this embodiment includes a theoretical simulation model and a three-dimensional reconstruction model;
based on the image data of B ultrasonic imaging or photoacoustic imaging, personalized theoretical simulation is carried out on a patient, so that acoustic energy distribution, temperature distribution and damage distribution in each treatment area in the treatment process are obtained, and intelligent dosage delivery is realized according to different treatment areas;
after personalized face three-dimensional reconstruction is carried out on the image data based on B ultrasonic imaging or photoacoustic imaging, treatment process data are stored in real time;
the transducer module in the theoretical simulation model is used for determining the frequency, the size and the treatment focal depth of the ultrasonic transducer;
the biological tissue module is used for meshing according to epidermis, shallow dermis, deep dermis, fat and SMAS layer image data acquired by the image data of B ultrasonic imaging or photoacoustic imaging;
the data collection module is the value of the acoustic-thermal parameter of each shallow tissue layer;
the data processing module comprises a pressure acoustic time domain display physical field, a domain normal differential and differential algebraic equation physical field and a biological heat transfer physical field;
the data feedback module is used for displaying acoustic energy distribution, temperature distribution and damage distribution;
the display acoustic energy distribution is obtained by combining a pressure acoustic time domain display physical field with a domain normal differential and differential algebraic equation physical field;
the temperature distribution and the damage distribution are obtained by combining a domain normal differential equation physical field and a differential algebraic equation physical field with a biological heat transfer physical field;
the calculation method for pressure acoustic time domain display in acoustic energy distribution comprises the following steps:
(1)
wherein diffraction, attenuation and nonlinear effects are introduced to the left of the equation,
representing sound pressure;
is the sound velocity;
is the diffusion coefficient of the thermal viscous medium;
is the density of the medium;
is a Laplacian operator;
representing time;
representing the nonlinear coefficient;
axisymmetric transducer sound field adopting a cylindrical coordinate system；
z is the propagation direction of the sound beam;
representing polar coordinates;
representing the partial derivative component of the coordinate in the r direction;
representing a partial derivative component of the coordinate in the z direction;
based on the calculation, the distribution of the sound field can be obtained;
the calculation method of the domain ordinary differential and differential algebraic equation is as follows:
(2)
wherein,and->Is the starting time and the ending time of integration, and the interval is the starting time and the ending time of the actual focus sound wave stable oscillation calculated in (1) in the pressure acoustic time domain display physical field, and is->、/>And->Are obtained from the piezoacoustic time domain display physical field.
The calculation method of the biological heat transfer module in the temperature distribution and the damage distribution comprises the following steps:
(3)
wherein,representing heat;
representing tissue temperature;
representing the coefficient of thermal conductivity;
representing the speed of sound in the tissue;
ρ represents the tissue density;
q is affected by two important parameters, the first being the absorption coefficient of the tissue and the second being the sound intensity. The heat source may be expressed as:
(4)
wherein the method comprises the steps of，The method is obtained by solving a domain normal differential and differential algebraic equation module;
is the average absorption coefficient of the tissue;
the tissue absorption coefficient and the transducer frequency are in a power law relation, and the calculation formula is as follows:
(5)
in the formula (5), the amino acid sequence of the compound,is the fundamental frequency;
is the absorption coefficient of tissue at the fundamental frequency;
is the frequency at higher harmonics;
b is a tissue dependent constant, which is between [0,2 ].
Since the absorption coefficient varies with the transducer frequency and higher harmonics occur in the nonlinear wave, the average absorption coefficient can be calculated by the following equation:
(6)
(7)
in the formula (6), the amino acid sequence of the compound,tissue absorption coefficient at nth harmonic;
n represents the last harmonic in the summation;
the ratio of the harmonic amplitude to the fundamental amplitude is calculated from the focus spectrum curve;
in the formula (7), the amino acid sequence of the compound,and->The mean square value of the sound pressure at the nth harmonic and the mean square value of the sound pressure at the fundamental frequency are respectively.
The Q value of any point can be obtained by calculating the average absorption coefficient and the mean square sound pressure.
Based on the theoretical simulation model, the sound pressure, temperature and damage distribution of different treatment areas can be obtained, the subcutaneous temperature is 60-75 ℃ in the treatment scheme selected for each patient, and meanwhile, the skin temperature and the subcutaneous damage area meet the preset requirements, namely, the conditions of lower skin temperature, moderate subcutaneous damage area and no damage to the skin are achieved, and different doses can be selected for treatment according to different treatment areas and subjective tolerance of the patient to pain at any time in the treatment process.
The three-dimensional reconstruction model comprises the following contents:
(1) Image preprocessing: preprocessing the acquired image data, including denoising, enhancement, edge detection and the like, so as to improve the image quality and definition;
the image data acquired in this embodiment includes image data of two-dimensional B-ultrasonic imaging and photoacoustic imaging.
(2) Image registration: for image data of a plurality of planes, image registration is required to be performed so that images are correctly aligned and corresponding in space;
(3) Voxelization: converting the preprocessed and registered image data into three-dimensional voxel data; the stacking and combination of voxels can form a complete three-dimensional structure, and the voxelization generally comprises the application of a voxelization algorithm, and the spatial reconstruction of the two-dimensional image data is carried out to generate three-dimensional voxel data;
(4) And (3) reconstructing the curved surface by using a MarchingCubes algorithm:
determining the intra-voxel and intra-voxel states: processing each voxel, determining whether the voxel belongs to the interior or the exterior of the object according to the gray value of the interior or the exterior of the voxel, and judging by using a threshold value, wherein the threshold value is higher than the interior and the threshold value is lower than the exterior;
vertex positioning: inside each voxel, determining the positions of vertexes to be inserted according to the gray value condition of the voxel boundary, wherein the positions of the vertexes are connected into a triangular grid in the subsequent step to represent a curved surface model;
generating a triangle: according to the condition of the internal vertexes of each voxel, a MarchingCubes algorithm predefines a series of possible internal conditions of the voxels, and a corresponding triangle combination mode is designated for each condition;
connection triangle: connecting triangles in adjacent voxels to ensure the continuity and integrity of the whole curved surface model;
gridding: finally, processing the generated triangle mesh, such as removing repeated edges, optimizing vertex layout and the like, so as to obtain a more compact and effective three-dimensional curved surface model;
the three-dimensional reconstruction module is simultaneously combined with sound field thermal field data of the theoretical simulation model, monitors the treatment progress based on real-time image data, displays the treatment process in real time, records and stores data, wherein the data comprises a moving track of a transducer on the three-dimensional reconstruction face model in the whole treatment process, a real-time sound field, a temperature field, subcutaneous injury distribution, actual focal depth and whole subcutaneous injury area of a subcutaneous treatment area of the face model below the track.
In this embodiment, the post-operation module needs to perform safety and effectiveness evaluation on image data and clinical observation after operation of the patient, and observe indexes:
(1) Whether the subcutaneous epidermis area in the image data appears the massive strong echo, if does not appear the strong echo phenomenon and gray change, show the therapeutic course has no damage to the epidermis, is safe treatment;
(2) Whether a subcutaneous treatment area in the image data has a massive strong echo or not, if the strong echo phenomenon and the gray level change occur, the effective damage of the treatment area is indicated, and the effective treatment is realized;
based on the postoperative image data, doctors can also selectively combine with a visual pain analog scale (VAS) to evaluate pain, wherein the total score is 10, 0 indicates no pain, more than 4 is obvious pain, and 10 indicates severe pain; the higher the score, the more pain is intense; the Visia skin analyzer detects the elasticity, moisture and the like of the skin of a patient, so that more comprehensive curative effect evaluation is performed.
The embodiment aims at the problem that standard safety and effectiveness treatment cannot be realized in the focused ultrasound beauty treatment process, is particularly suitable for the three small modules in the image data monitoring module before, during and after operation to cover the whole focused ultrasound beauty treatment process, provides an alternative scheme for carrying out the focused ultrasound beauty treatment, and provides a solution for improving the safety and effectiveness of the focused ultrasound beauty treatment.
The above-described embodiments are merely preferred embodiments for fully explaining the present invention, and the scope of the present invention is not limited thereto. Equivalent substitutions and modifications will occur to those skilled in the art based on the present invention, and are intended to be within the scope of the present invention. The protection scope of the invention is subject to the claims.
The invention discloses a method and a system for generating a focused ultrasound beauty treatment dosage delivery scheme based on image data, which relate to the technical field of high-intensity focused ultrasound facial rejuvenation. The visualization system ensures that the device and skin are properly attached and remain at the proper depth during treatment, preventing false targeting of other tissues, such as bones, nerves, etc., minimizing unnecessary pain and side effects. An experienced operator may select a particular depth and energy level for the patient based on the visualization data to achieve personalized treatment; solves the problem that the prior domestic focused ultrasound beauty treatment can not realize standard safety and effectiveness treatment.
Claims (9)
1. The method for generating the focused ultrasonic beauty treatment dosage plan based on the image data is characterized by comprising the following steps of: the method comprises the following steps:
acquiring image data of a treatment area;
constructing a biological tissue layer model according to the image data;
determining parameters for selecting the ultrasonic transducer according to the image data;
constructing a theoretical simulation model according to the biological tissue layer model and the ultrasonic transducer, wherein the theoretical simulation model is used for simulating sound field thermal field data in the focused ultrasonic treatment process; analyzing and processing according to the sound field thermal field data to obtain a focused ultrasound dose delivery scheme;
the focused ultrasound dosing regimen is presented on a visualization system disposed on the ultrasound transducer.
2. The method for generating the focused ultrasound cosmetic dose delivery scheme based on the image data as claimed in claim 1, wherein the method comprises the following steps: the theoretical simulation model is constructed according to the following steps:
acquiring parameters for constructing the transducer;
constructing each biological tissue layer model according to the image data;
acquiring acoustic parameters and thermal parameters of each biological tissue layer model;
performing simulation calculation according to parameters of the transducer and the biological tissue layer model to obtain a sound field result and a thermal field result;
and calculating according to the obtained sound field result and the obtained thermal field result to obtain any one or more of sound pressure distribution, temperature distribution, damage distribution and thermal dose distribution of different areas in the treatment process.
3. The method for generating the focused ultrasound cosmetic dose delivery scheme based on the image data as claimed in claim 1, wherein the method comprises the following steps: the focused ultrasonic dose delivery value in the focused ultrasonic dose delivery scheme is calculated according to the following formula:
wherein TD is the thermal dose; t is the tissue temperature; t represents time; r represents a numerical value, r=0.25 when T is equal to or less than 43 ℃; when T > 43 ℃, r=0.5.
4. The method for generating the focused ultrasound cosmetic dose delivery scheme based on the image data as claimed in claim 1, wherein the method comprises the following steps: the image data comprises B ultrasonic imaging data or/and photoacoustic imaging data.
5. The system for generating the focused ultrasonic beauty treatment dosage plan based on the image data is characterized in that: the system comprises a theoretical simulation model, a treatment device, a treatment parameter setting module and an image monitoring module;
the theoretical simulation model is used for simulating sound field thermal field data in the focused ultrasound treatment process; analyzing and processing according to the sound field thermal field data to obtain a focused ultrasound dose delivery scheme;
the treatment device is used for treating the ultrasonic energy output from the treatment area and collecting image data of the treatment process;
the treatment parameter setting module is used for setting the type of the treatment probe and the parameters of the treatment process;
the image monitoring module is used for storing the acquired image data and outputting the dose delivery and curative effect evaluation results.
6. The image data-based focused ultrasound cosmetic dose delivery regimen generation system of claim 5, wherein: the dosage and curative effect evaluation results are carried out in the following modes:
judging whether a lump type strong echo appears in a subcutaneous epidermis region in the image data, if the strong echo phenomenon and the gray level change do not appear, the method indicates that the epidermis is not damaged in the treatment process, and the safety treatment is realized;
judging whether a subcutaneous treatment area in the image data has a massive strong echo, and if the strong echo phenomenon and the gray level change occur, indicating that the treatment area is effectively damaged, and treating effectively.
7. The image data-based focused ultrasound cosmetic dose delivery regimen generation system of claim 5, wherein: the focused ultrasonic dose delivery value in the focused ultrasonic dose delivery scheme is calculated according to the following formula:
wherein TD is the thermal dose; t is the tissue temperature; t represents time; r represents a numerical value, r=0.25 when T is equal to or less than 43 ℃; when T > 43 ℃, r=0.5.
8. The image data-based focused ultrasound cosmetic dose delivery regimen generation system of claim 5, wherein: the theoretical simulation model comprises a transducer module, a biological tissue module, a data collection module, a data processing module and a data feedback module;
the transducer module is used for constructing the geometric structure, frequency and output parameters of the transducer;
the biological tissue module is used for constructing each biological tissue layer model based on the image data;
the data collection module is used for endowing each constructed biological tissue layer model with corresponding acoustic parameters and thermal parameters, wherein the acoustic parameters comprise any one or more of sound velocity, density, attenuation coefficient and nonlinear coefficient; the thermal parameters include tissue specific heat capacity or/and thermal conductivity;
the data processing module is used for performing simulation calculation to obtain a sound field result and a thermal field result after the transducer module, the biological tissue module and the data collection module are all arranged;
the data feedback module is used for performing post-processing on the data calculated by the data processing module to obtain any one or more of sound pressure distribution, temperature distribution, damage distribution and thermal dose distribution of different areas in the treatment process.
9. The image data-based focused ultrasound cosmetic dose delivery regimen generation system of claim 5, wherein: the image monitoring module comprises a preoperative module, an intraoperative module and a postoperative module;
the preoperative module is used for screening transducers with different depths required by the patient to treat different areas through image data;
the intraoperative module is used for monitoring sound pressure distribution, temperature distribution and damage distribution of different areas in the treatment process through image data;
the postoperative module is used for evaluating the treatment effect by the image data.
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