CN117731255A - Pump blood conduit assembly and heart blood flow auxiliary system - Google Patents

Abstract

The utility model provides a pump blood conduit subassembly and heart blood flow auxiliary system, it includes the fluid pipe, liquid filling mechanism and drawing liquid pump, be equipped with the suction inlet and the egress opening that communicate and lie in temperature regulating tube portion and temperature measuring tube portion respectively on the fluid pipe, the drawing liquid pump that sets up between suction inlet and egress opening is used for pumping blood, liquid filling mechanism is used for filling the liquid that changes blood temperature into the target object, the temperature measuring tube is arranged in measuring the temperature of blood in the target blood vessel that communicates with the target object, after filling liquid in the target object, the temperature of target blood vessel blood can change, corresponding heart with the temperature measuring tube portion is to be surveyed can be obtained through Stuttgart-hamilton formula, because the output volume that this mode obtained is calculated according to blood flow temperature, it is more direct according to the mode of calculating heart output volume through the current parameter of motor, and not influenced by factors such as motor fatigue, pump blood conduit position, this pump blood conduit subassembly is favorable to improving the accuracy to heart output volume measurement.

Description

Pump blood conduit assembly and heart blood flow auxiliary system

Technical Field

The application relates to the technical field of medical equipment, in particular to a blood pumping catheter assembly and a heart blood flow auxiliary system.

Background

The heart is an important organ that provides the motive force for the blood circulation of the human body. Cardiac output is an important indicator of whether or not the heart is functioning properly.

For some patients suffering from heart diseases such as heart failure, the cardiac output of the heart is difficult to meet the needs of the body, and the heart is a great threat to the health of the body. The use of a pump line as a means of increasing the cardiac transfusion volume of the heart has become an important aid in the treatment of patients suffering from heart disease.

For patients using a pumping catheter, the cardiac output is composed of two parts, namely the pumping volume of the pumping catheter and the output of their own heart. The blood pumping amount of the blood pumping catheter is taken as an important parameter of the blood pumping catheter, and is usually obtained by converting and calculating the current of a blood pumping motor and the pressure difference between an aorta and a ventricle in the related art, and the blood pumping amount is influenced by factors such as motor fatigue, the position of the blood pumping catheter and the like, so that the measurement of the blood pumping amount of the blood pumping catheter is often inaccurate, and the calculation of cardiac output is also inaccurate.

Disclosure of Invention

In view of the foregoing, the present application provides a pumping catheter assembly and a heart blood flow assist system, which facilitate improving accuracy of cardiac output measurement.

In a first aspect, the present application provides a pump blood conduit assembly, the pump blood conduit assembly including a fluid tube and a liquid charging mechanism, the fluid tube including a temperature-regulating tube portion and a temperature-measuring tube portion, the fluid tube being provided with a suction inlet and a discharge outlet which are communicated with each other at intervals, the suction inlet and the discharge outlet being located in the temperature-regulating tube portion and the temperature-measuring tube portion, respectively; the liquid filling port of the liquid filling mechanism is positioned at the temperature regulating pipe part, the liquid filling mechanism is configured to fill liquid for changing the temperature of blood into a target object, the temperature measuring pipe part is configured in a target blood vessel communicated with the target object, and the temperature measuring pipe part is used for measuring the temperature of the blood; wherein the target object is one of a ventricle, an atrium, an superior vena cava, and an inferior vena cava;

and a fluid pump disposed in the fluid line between the suction port and the outflow port for pumping blood from the target subject into the target blood vessel.

In the blood pumping catheter assembly provided by the specific embodiment of the application, the first temperature measuring piece is arranged in the temperature measuring tube part, and the first temperature measuring piece is positioned on one side of the outflow opening, which is close to the temperature adjusting tube part.

In the pump blood conduit assembly provided in the specific embodiment of the application, the liquid filling port of the liquid filling mechanism is arranged in the temperature adjusting pipe part, and the liquid filling port is positioned at one side of the inflow port, which is close to the temperature adjusting pipe part.

In the blood pumping catheter assembly provided in the specific embodiment of the application, the first temperature measuring piece comprises a first thermistor, and the first thermistor is connected to the inner wall of the temperature measuring tube portion.

In the blood pumping catheter assembly provided by the specific embodiment of the application, the second temperature measuring piece is arranged outside the temperature measuring tube part, and the second temperature measuring piece is positioned on one side of the outflow port away from the temperature adjusting tube part.

In the pump-catheter assembly provided in the embodiment of the present application, the liquid filling port of the liquid filling mechanism is provided outside the temperature adjustment tube portion.

In the pump-blood conduit assembly provided in the embodiment of the present application, the end of the temperature-adjusting tube portion, which is far away from the temperature-measuring tube portion, is provided with the introduction tube portion, and the liquid filling port of the liquid filling mechanism is provided in the introduction tube portion.

In the blood pumping catheter assembly provided by the specific embodiment of the application, the ingress pipe portion is provided with an arc-shaped structure, and the arc-shaped structure is located at the end portion, far away from the temperature regulating pipe portion, of the ingress pipe portion.

In the blood pumping catheter assembly provided in the specific embodiment of the application, a sheath tube portion is arranged at a position, far away from the outflow port, on the temperature measuring tube portion, and the second temperature measuring member is arranged outside the sheath tube portion.

In the blood pumping catheter assembly provided by the specific embodiment of the application, the second temperature measuring piece comprises a second thermistor, and the second thermistor is arranged on the outer wall of the temperature measuring tube part.

In the pump blood conduit assembly provided in the specific embodiment of the application, the liquid filling mechanism comprises a liquid filling device, a liquid filling channel is arranged on the fluid pipe, a liquid inlet of the liquid filling channel is communicated with the liquid filling device, and liquid for changing the blood temperature is filled into the target object through a liquid outlet of the liquid filling channel by the liquid filling mechanism.

In the pump-catheter assembly provided in the specific embodiment of the application, the fluid tube is provided with a liquid injection tube, and a liquid injection channel is formed inside the liquid injection tube.

In a pump-catheter assembly provided in embodiments of the present application.

In the pump-blood conduit assembly provided in the specific embodiment of the application, a flow channel is arranged in the wall of the fluid pipe, and the flow channel forms a liquid filling channel.

In a second aspect, the present application provides a cardiac blood flow assist system, including a pump-catheter assembly as provided in any one of the above aspects, and a controller electrically connected to the temperature sensing tube portion and the fluid-filling mechanism, the controller configured to control the fluid-filling mechanism to fill a target subject with fluid, the controller configured to control the temperature sensing tube portion to sense temperature, and the controller configured to calculate a cardiac output based on the sensed temperature of the temperature sensing tube portion.

The technical scheme provided by the embodiment of the disclosure at least brings the following beneficial effects:

the application provides a blood pumping catheter assembly, which comprises a fluid pipe, a liquid filling mechanism and a liquid extracting pump, wherein the fluid pipe is provided with a suction inlet and a discharge outlet which are communicated and respectively positioned at a temperature regulating pipe part and a temperature measuring pipe part, the liquid extracting pump arranged between the suction inlet and the discharge outlet is used for pumping blood, the liquid filling mechanism is used for filling liquid for changing the temperature of the blood into a target object, and the temperature measuring pipe is used for measuring the temperature of the blood in a target blood vessel communicated with the target object; wherein the target object may be one of a ventricle, an atrium, a superior vena cava, an inferior vena cava. After the liquid is filled into the target object, the liquid pump pumps the blood from the target object into the target blood vessel, the temperature of the blood in the target blood vessel can be changed, and the corresponding blood output (cardiac output) to be measured by the temperature measuring tube part can be obtained by utilizing the Stuttgart-Hamiltonian formula according to the change value of the temperature of the blood, the temperature of the filled liquid and the volume of the filled liquid. In addition, if the cardiac output of the patient using the pump-catheter assembly can be measured, the total cardiac output of the patient can be measured without using additional other devices, so that adverse events in the process of using the pump-catheter assembly and other devices are avoided.

The foregoing description is only an overview of the technical solutions of the present application, and may be implemented according to the content of the specification in order to make the technical means of the present application more clearly understood, and in order to make the above-mentioned and other objects, features and advantages of the present application more clearly understood, the following detailed description of the present application will be given.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the application. Also, like reference numerals are used to designate like parts throughout the figures. In the drawings:

FIG. 1 is a schematic illustration of a pump-catheter assembly provided in some embodiments of the present application;

FIG. 2 is a schematic illustration of another pump-catheter assembly provided in some embodiments of the present application;

FIG. 3 is a schematic view of a pump-catheter assembly according to some embodiments of the present disclosure, wherein a flow channel is provided in a wall of a fluid tube;

fig. 4 is a schematic view of another structure of a pump-catheter assembly according to some embodiments of the present disclosure, in which a flow channel is provided in a wall of a fluid tube.

Reference numerals in the specific embodiments are as follows:

1. a fluid pipe; 11. a temperature adjusting pipe part; 12. a temperature measuring tube part; 121. a first temperature measuring member; 122. a second temperature measuring member; 13. a suction inlet; 14. an outflow port; 15. an introduction pipe section; 16. a sheath tube portion; 17. a bending structure; 18. a flow passage; 19. a liquid filling port; 2. a liquid injection pipe; 10. a target object; 20. a target blood vessel; 30. aortic valve.

Detailed Description

Embodiments of the technical solutions of the present application will be described in detail below with reference to the accompanying drawings. The following examples are only for more clearly illustrating the technical solutions of the present application, and thus are only examples, and are not intended to limit the scope of protection of the present application.

It should be noted that unless otherwise indicated, technical or scientific terms used in the embodiments of the present application should be given the ordinary meanings as understood by those skilled in the art to which the embodiments of the present application belong.

In the description of the embodiments of the present application, the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the embodiments of the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the embodiments of the present application.

Furthermore, the technical terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the description of the embodiments of the present application, the meaning of "plurality" is two or more unless explicitly defined otherwise.

In the description of the embodiments of the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured" and the like are to be construed broadly and may, for example, be fixedly connected, detachably connected, or be integrated; or may be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the embodiments of the present application will be understood by those of ordinary skill in the art according to the specific circumstances.

In the description of embodiments of the present application, unless explicitly specified and limited otherwise, a first feature "up" or "down" on a second feature may be that the first and second features are in direct contact, or that the first and second features are in indirect contact via an intermediary. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

The heart is an important organ that provides the motive force for the blood circulation of the human body. Cardiac output is an important indicator of whether the heart is normal or not, and is used for measuring the intensity of the ejection function of the heart. When suffering from heart diseases such as heart failure, cardiac output of the heart is difficult to meet the needs of the body, and a heart blood flow auxiliary system becomes an important therapeutic means.

A blood pumping catheter in the heart blood flow auxiliary system passes through the skin surface, enters the aortic vascular system through a femoral artery puncture passage, passes through an aortic arch and across an aortic valve to enter a left ventricle, a blood flow channel is formed between the left ventricle and the aorta, an inlet of the blood flow channel is positioned in the left ventricle, and an outlet of the blood flow channel is positioned in the aorta. The blood pumping catheter delivers blood in the left ventricle into the aorta by high speed rotation of the drive train and impeller, after which the blood flows to various tissues and organs throughout the body. Providing auxiliary blood circulation support for patients, reducing heart burden and oxygen consumption of patients and helping heart function recovery.

The clinical effect of a pumping catheter is to increase the cardiac output of a patient, which is an important indicator of whether the cardiac function is normal or not, and for patients receiving pumping catheter treatment, the total cardiac output includes the natural cardiac output of the patient and the pumping volume of the pumping catheter. The patient's natural cardiac output is an important hemodynamic parameter for assessing the patient's heart recovery and treatment progress following pump catheter treatment. The pumping quantity of the pumping catheter is an important parameter for measuring whether the pumping catheter is in normal operation or not, and is an important basis for guiding the use of the pumping catheter.

Currently, methods for measuring cardiac output mainly include imaging (ultrasound and nuclear magnetic resonance), impedance, and indicator dilution (fuel dilution, thermal dilution). However, for patients undergoing pump catheter treatment, these measurement methods only measure the total cardiac output and do not directly obtain the patient's natural cardiac output and the pump volume of the pump catheter, respectively. Currently, for the pumping quantity of a pumping catheter which measures whether the pumping catheter works normally, the pumping quantity of the pumping catheter is usually calculated indirectly by using a parameter conversion mode such as a pumping motor. The calculation mode of the transformation uses the current as a parameter to calculate, and is influenced by factors such as motor fatigue, the position of a blood pumping catheter and the like, so that the measurement of the blood pumping quantity of the blood pumping catheter is often inaccurate.

In order to improve accuracy of measurement of cardiac output, the applicant has conducted intensive studies to design a pump-blood conduit assembly including a liquid filling mechanism for filling blood in a ventricle, atrium, superior vena cava or inferior vena cava as a target object with liquid, a fluid tube in the pump-blood conduit assembly including a temperature-regulating tube portion provided with a liquid filling port of the liquid filling mechanism and a temperature-measuring tube portion for measuring a temperature of blood in a target blood vessel communicating with the target object. After filling liquid into a target object, a liquid pump pumps blood into a target blood vessel from the target object, the temperature of the blood in the target blood vessel corresponding to the target is changed, and according to the change value of the temperature of the blood, the temperature of the filled liquid and the volume of the filled liquid, the corresponding blood output quantity (cardiac output quantity) to be measured by a temperature measuring tube part can be obtained by utilizing a Stuttgart-Hamiltonian formula, and can be the pump blood flow quantity or the total cardiac output quantity of a pump blood tube assembly. In addition, if the cardiac output of the patient using the pump-catheter assembly can be measured, the total cardiac output of the patient can be measured without using additional other devices, so that adverse events in the process of using the pump-catheter assembly and other devices are avoided.

The technical solutions of the pump-catheter assembly and the heart blood flow assisting system provided in the present application are further described below with reference to the accompanying drawings and by means of specific embodiments.

The application provides a pump blood conduit assembly, the pump blood conduit assembly comprises a fluid pipe 1, a liquid filling mechanism and a liquid drawing pump, as shown in fig. 1 and 2, the fluid pipe 1 comprises a temperature regulating pipe part 11 and a temperature measuring pipe part 12, a suction inlet 13 and a discharge outlet 14 which are communicated are arranged on the fluid pipe 1 at intervals, the suction inlet 13 and the discharge outlet 14 are respectively positioned on the temperature regulating pipe part 11 and the temperature measuring pipe part 12, a liquid filling port 19 of the liquid filling mechanism is positioned on the temperature regulating pipe part, the liquid filling mechanism is used for filling liquid for changing the temperature of blood into a target object, the temperature measuring pipe part is arranged in a target blood vessel 20 communicated with the target object, and the temperature measuring pipe part is used for measuring the temperature of blood; a liquid pump is provided between the suction port 13 and the outflow port 14 for pumping blood from the target subject into the target blood vessel 20.

The target object 10 is one of a ventricle, an atrium, an superior vena cava or an inferior vena cava, and the target blood vessel 20 is an arterial blood vessel communicating with the target object 10. When the target object is the left ventricle or left atrium of the heart, the target vessel 20 is the aorta, and the pump catheter assembly is capable of delivering blood into the aorta in communication therewith; when the target object 10 is the right ventricle, right atrium, superior vena cava, or inferior vena cava of the heart, the target vessel 20 is a pulmonary artery, and the pump-catheter assembly is capable of delivering blood into the pulmonary artery in communication therewith. The temperature change of the blood measured by the temperature measuring tube portion 12 is consistent with the principle of operation of obtaining cardiac output (the amount of blood pumped by a blood conduit, the total amount of cardiac output (TCO, total Cardiac Output)) by using the schart-hamilton equation based on the temperature of the fluid filled and the volume of the fluid filled, regardless of which of the left ventricle, the left atrium, the right ventricle, the right atrium, the superior vena cava, and the inferior vena cava is located in the temperature adjusting tube portion 11. For convenience of description, the following will take the target object 10 as the left ventricle of the heart and the target blood vessel 20 as the aorta as an example.

The fluid tube 1 may be a tube member capable of passing blood, and provided with a suction port 13 and an outflow port 14 provided at intervals, the suction port 13 and the outflow port 14 being provided in communication such that blood of the fluid tube 1 entering from the suction port 13 can flow out from the outflow port 14. The fluid tube 1 serves as the main component in the pump-catheter assembly for crossing the aortic valve 30, with the suction opening 13 in the left ventricle and the outflow opening 14 in the aorta, from which blood can enter the aorta through the fluid tube 1.

The fluid tube 1 comprises a temperature-regulating tube portion 11 and a temperature-measuring tube portion 12, the suction inlet 13 and the outflow opening 14 are respectively positioned at the temperature-regulating tube portion 11 and the temperature-measuring tube portion 12, when the fluid tube 1 crosses the aortic valve 30, the temperature-regulating tube portion 11 and the temperature-measuring tube portion 12 are respectively positioned in the left ventricle and the aorta, the temperature-regulating tube portion 11 is used for regulating the temperature of blood in the left ventricle, and the temperature-measuring tube is used for measuring the temperature of blood in the aorta.

The liquid charging mechanism may be a mechanism capable of generating pressure on the liquid and causing the liquid to flow in a predetermined direction. The liquid charging port 19 of the liquid charging mechanism is provided in the temperature adjustment pipe portion 11 so that the liquid charging mechanism can deliver the liquid to the temperature adjustment pipe portion 11. The liquid may be a liquid filled in the left ventricle capable of changing the temperature of blood in the left ventricle, which can raise the temperature of blood and lower the temperature of blood, and the temperature change of blood caused by the liquid and the type of the liquid do not influence and damage the health of human body. In some embodiments, the fluid may be saline at a temperature lower than the temperature of blood in the left ventricle, which when filled into the left ventricle may cause a decrease in the temperature of the blood. Preferably, the temperature of the physiological saline may be formulated to be in the range of 0-10 ℃, which causes a decrease in the temperature of blood in the left ventricle after filling the left ventricle, and the temperature measuring tube part 12 measures the temperature of the blood after the blood having been lowered in temperature is transferred into the main artery, and the temperature change of the blood may be recorded. Here, filling the left ventricle with the liquid may be referred to as filling the left ventricle outside the temperature adjustment tube portion 11 with blood, or may be referred to as filling the left ventricle inside the temperature adjustment tube portion 11 placed in the left ventricle.

The liquid pump may be a pump body capable of transporting blood, and is capable of transporting blood in a certain direction. The liquid pump is connected to the fluid tube 1 and is positioned between the suction inlet 13 and the outflow port 14, so that blood is conveyed from the suction inlet 13 to the outflow port 14, and the blood in the left ventricle is conveyed into the aorta, so that pumping of the blood is realized.

The liquid pump may be an impeller pump, in which an impeller is rotatably connected to the inner wall of the fluid pipe 1, and blood can be sent from the inlet port 13 to the outlet port 14 when the impeller rotates. The motor is integrated in the liquid pump, and the output end of the motor is in transmission connection with the impeller, so that the impeller can be driven to rotate, and the blood is conveyed.

When the cooled blood in the left ventricle enters the aorta, the temperature of the blood in the aorta can be changed, and the heart output can be obtained through the Stuttgart-Hamiltonian formula as shown in the formula 1, and the accuracy of heart output measurement can be improved due to the fact that the heart output obtained through the method is not influenced by factors such as motor fatigue, the position of a blood pumping catheter and the like.

Wherein CO is cardiac output, tb is the temperature of blood before cooling, ti is the temperature of blood after cooling, vi is the heating coefficient of blood, K is the calibration coefficient, +.DELTA.T _b X dt is the integral of the temperature difference of the blood over time.

In some embodiments, as shown in FIG. 1, the liquid flowing out of the liquid filling port 19 of the liquid filling mechanism can cool the blood flowing into the suction port 13, and the temperature measuring tube part 12 can measure the temperature of the blood flowing out of the outlet 14After the temperature difference of the blood is recorded by the control equipment outside the blood pumping catheter assembly, the heart output can be obtained through the measured temperature change of the blood by utilizing the Stuttgart-Hamilton formula. Since the temperature-adjusting tube portion 11 is cooled by the blood flowing through the fluid tube 1 at this time, the temperature-measuring tube portion 12 is also measured by the blood flowing through the fluid tube 1, and the cardiac output obtained at this time is the pumping blood volume of the pumping blood tube, that is, the pumping blood volume of the pumping blood tube can be measured by the method of fig. 1, and the measurement is simple and relatively accurate. At this time, CO in the formula (1) is the pumping volume of the pumping tube, tb is the temperature of the blood flowing through the fluid tube 1 before the temperature is lowered, ti is the temperature of the blood flowing through the fluid tube 1 after the temperature is lowered, vi is the heating coefficient of the blood, K is the calibration coefficient, ++DeltaT _b X dt is the integral of the temperature difference of the blood in the fluid tube 1 with respect to time.

In some embodiments, as shown in fig. 1, a liquid charging port 19 of the liquid charging mechanism is located between the suction port 13 and the outflow port 14 and is communicated with the inside of the temperature-adjusting pipe portion 11; the temperature measuring tube 12 is provided with a first temperature measuring member 121 inside, and the first temperature measuring member 121 is positioned at one side of the outflow opening 14 near the temperature adjusting tube 11. Preferably, the first temperature measuring member 121 abuts against the outflow opening 14, reducing the measurement error.

The liquid filling port 19 of the liquid filling mechanism is located between the suction port and the outflow port and is communicated with the inside of the temperature regulating tube part, so that the liquid filled in the liquid filling mechanism directly flows into the inside of the temperature regulating tube part between the suction port and the outflow port, and the temperature of blood in the temperature regulating tube part is reduced. The temperature of the blood flowing through the fluid pipe 1 can be lowered by the liquid filling port 19 of the liquid filling mechanism which is located between the suction port 13 and the outflow port 14 and is communicated with the inside of the temperature adjustment pipe portion 11, and the temperature of the blood flowing out of the fluid pipe 1 can be lowered. The first temperature measuring member 121 may be a member capable of measuring the temperature of the blood flowing through itself, so that the temperature difference of the blood flowing through itself before and after heating can be known, and is provided on the inner wall of the temperature measuring tube portion 12 at the side of the outflow port 14 near the temperature adjusting tube portion 11, and the temperature of the blood flowing out of the outflow port 14 can be measured. The temperature of the blood flowing through the temperature adjustment tube part 11 is reduced by communicating the liquid filling port 19 of the liquid filling mechanism with the inside of the temperature adjustment tube part 11, and the temperature difference of the blood flowing through the fluid tube 1 can be measured by the pump-blood conduit assembly by arranging the first temperature measuring member 121 on the inner wall of the temperature measurement tube part 12 and on the side of the outflow port 14 close to the temperature adjustment tube part 11, so that the pump-blood volume of the pump-blood conduit can be obtained by the formula (1). At this time, the liquid filled in the liquid filling mechanism directly moves and mixes in the fluid tube 1 along with the blood in the fluid tube 1, and the temperature change measured by the first temperature measuring member 121 is more accurate, so that the obtained pump blood volume is more accurate. Preferably, the fill port 19 is in close proximity to the intake port 13, and the calculated amount of pump blood is more accurate.

The temperature of the liquid filled in the blood can be set by a person skilled in the art according to the actual situation, so that the temperature of the liquid blood can be reduced without damaging blood cells.

Preferably, the fluid tube 1 has good heat insulation capability, and the liquid filling mechanism can reduce the inward diffusion of heat outside the fluid tube 1 and improve the accuracy of the blood pumping amount of the blood pumping catheter assembly when the blood flowing through the inner cavity of the fluid tube 1 is filled with liquid to cool. Specifically, the fluid pipe 1 may be made of plastic, which has low thermal conductivity, so that the fluid pipe 1 has good heat insulating capability.

In some embodiments, as shown in fig. 2, the temperature-adjusting tube 11 may be used to cool the blood in the left ventricle, the temperature-adjusting tube 12 may be used to measure the temperature of the whole blood flowing into the main artery, and after the temperature difference of the blood is recorded, the heart output can be obtained by using the ston-hamilton equation through the measured temperature change of the blood. Since the temperature-adjusting tube portion 11 is cooled down to blood in the entire left ventricle at this time, the object of the temperature measurement by the temperature-adjusting tube portion 12 is also the whole blood in the aorta, and the cardiac output obtained at this time is the cardiac output total amount. At this time, CO in the formula (1) is the total cardiac output, tb is the temperature of the whole blood flowing into the aorta before cooling, ti is the temperature of the whole blood flowing into the aorta after cooling, vi is the heating coefficient of the blood, K is the calibration coefficient, ++DeltaT _b X dt is the integral of the temperature difference of the whole blood in the aorta over time.

The total cardiac output obtained by the mode is not influenced by factors such as motor fatigue, the position of the pumping blood conduit and the like, and the pumping blood conduit assembly is beneficial to improving the accuracy of cardiac output measurement.

As shown in fig. 2, the liquid filling port 19 of the liquid filling mechanism is provided outside the temperature-adjusting tube portion 11, the second temperature measuring member 122 is provided outside the temperature-measuring tube portion 12, and the second temperature measuring member 122 is located at a side of the outflow port 14 away from the temperature-adjusting tube portion 11.

The liquid filling port 19 of the liquid filling mechanism is communicated with the outside of the temperature regulating tube part 11, so that the liquid filled in the liquid filling mechanism directly flows into the left ventricle communicated with the outside of the temperature regulating tube part 11, and the temperature of blood in the left ventricle outside the temperature regulating tube part 11 is reduced. The liquid filling port 19 of the liquid filling mechanism, which is connected to the outside of the temperature adjustment tube 11, can cool down the blood in the left ventricle, and reduce the temperature of the blood flowing from the left ventricle into the aorta. The second temperature measuring member 122 may be a member that can measure the temperature of the blood flowing through itself, so that the temperature difference of the blood flowing through itself before and after the temperature reduction can be known, and is provided outside the temperature measuring tube part 12 on the side of the flow away from the temperature adjusting tube part 11, and measures the temperature of the blood in the left ventricle.

The liquid filling port 19 of the liquid filling mechanism is arranged outside the temperature adjusting tube part 11, so that the liquid filling mechanism cools the blood of the whole left ventricle, and the second temperature measuring member 122 is arranged outside the temperature measuring tube part 12 and at the side of the outflow port 14 away from the temperature adjusting tube part 11, so that the pump-blood conduit assembly can measure the temperature difference of the whole blood flowing into the aorta from the left ventricle, so that the total heart output amount can be obtained by the formula (1).

With continued reference to fig. 2, a liquid charging port 19 of the liquid charging mechanism is provided outside the temperature adjustment pipe portion 11; the temperature measuring tube 12 is provided with a first temperature measuring member 121 inside, and the first temperature measuring member 121 is positioned at one side of the outflow opening 14 near the temperature adjusting tube 11.

The liquid filling port 19 of the liquid filling mechanism is communicated with the outside of the temperature adjusting tube part 11, so that the liquid filling mechanism cools the blood of the whole left ventricle. The first temperature measuring member 121 is disposed on the inner wall of the temperature measuring tube 12 and is located at one side of the outflow port 14 near the temperature adjusting tube 11, the first temperature measuring member 121 is adjacent to the outflow port 14, and measures the temperature of the blood flowing out of the outflow port 14. Under the action of the liquid pump, part of blood in the left ventricle enters the fluid tube 1 through the suction inlet 13, reaches the outflow port 14, flows out through the outflow port 14, and the temperature difference of the blood flowing through the fluid tube 1 can be measured by the pump-blood conduit assembly by arranging the first temperature measuring member 121 on the inner wall of the temperature measuring tube part 12 and on the side of the outflow port 14 close to the temperature adjusting tube part 11, so that the pump-blood volume of the pump-blood conduit can be obtained by the formula (1).

Preferably, the first temperature measuring member 121 is located next to the outflow port 14, so that the temperature of the blood flowing out of the outflow port 14 can be immediately measured by the first temperature measuring member 121, reducing the variation in blood temperature due to blood transport, and facilitating the improvement of the accuracy of the measured variation in blood temperature, and thus facilitating the improvement of the accuracy of the amount of blood pumped to the blood pumping catheter.

The amount of blood pumped by the blood pumping tube and the total cardiac output (TCO, total Cardiac Output) are obtained, and the total cardiac output minus the amount of blood pumped by the blood pumping tube is the natural cardiac output of the patient.

In other embodiments, only the total cardiac output may be measured by providing only the second temperature measuring member 122 and not providing the first temperature measuring member 121 in the temperature measuring tube portion 12.

In some implementations of the present application, the first temperature sensing member 121 includes a first thermistor coupled to an inner wall of the temperature sensing tube portion 12.

The thermistor is used as the first temperature measuring member 121, so that the first temperature measuring member 121 has high sensitivity, and the temperature change of the blood conveyed in the fluid tube 1 can be obtained more accurately.

The first thermistor may be connected to the inner wall of the temperature-sensing tube portion 11 by a connecting member such as a screw, a rivet, or the like, and may be adhered to the inner wall of the temperature-sensing tube portion 12 by glue.

Preferably, the liquid filling port 19 of the liquid filling mechanism is positioned at a side of the suction port 13 away from the temperature measuring tube part 12.

By arranging the liquid filling port 19 of the liquid filling mechanism at the side of the suction port 13 away from the temperature measuring tube part 12, the liquid filling port 19 of the liquid filling mechanism is positioned in the left ventricle, and the uniformity of cooling the blood in the left ventricle by the liquid flowing out of the liquid filling port 19 of the liquid filling mechanism is improved.

In some embodiments, an end of the temperature tube portion 11 remote from the temperature tube portion 12 is provided with an introduction tube portion 15, and a filling port 19 of the filling mechanism is provided in the introduction tube portion.

The introduction pipe portion 15 may refer to a structure that facilitates the introduction of the fluid pipe 1 from the target blood vessel into the heart, which is disposed at an end of the temperature-adjusting pipe portion 11 away from the temperature-adjusting pipe portion 12, and the introduction pipe portion 15 can facilitate the intervention of the pump-blood pipe assembly into the corresponding target blood vessel or blood transfusion organ of the human body through the percutaneous operation.

Preferably, the inlet pipe portion 15 is provided with an arc-shaped structure, which is located at an end of the inlet pipe portion 15 remote from the temperature-adjusting pipe portion 11. The introduction pipe portion 15 is advantageous in reducing damage to the target blood vessel and the cardiac muscle caused during implantation of the fluid pipe 1 into the human body by disposing an arc-shaped structure at an end portion remote from the temperature adjustment pipe portion 11.

By opening the liquid filling port 19 of the liquid filling mechanism in the inlet pipe portion 15 and communicating with the outside, the liquid filling port 19 of the liquid filling mechanism is located further inside the left ventricle, so that the uniformity of cooling of the liquid flowing out of the liquid filling port 19 of the liquid filling mechanism to the blood in the left ventricle is improved.

In some embodiments, the temperature measuring tube portion 12 is provided with a sheath tube portion 16 at a position far from the outflow port 14, and the second temperature measuring member 122 is disposed outside the sheath tube portion 16.

Sheath portion 16 is a flexible, bendable structure that does not cause structural damage to a corresponding target vessel or transfusion organ of the human body when the corresponding target vessel or transfusion organ is accessed by percutaneous surgery, and is capable of well adapting to the curved or spiral shape of the corresponding blood line. The sheath tube portion 16 may connect the fluid tube 1 with a controller or the like outside the human body, and may be internally provided with a cable or the like so as to realize connection of the first temperature measuring member 121, the second temperature measuring member 122 and the like in the pump-blood catheter assembly with the external device of the human body, so that the components in the pump-blood catheter assembly can normally operate according to a preset state.

In some embodiments, second temperature measurement member 122 is disposed on an outer wall of sheath portion 16.

By disposing the second temperature measuring member 122 on the outer wall of the sheath tube portion 16, the second temperature measuring member 122 is positioned on the side of the outflow port 14 away from the temperature adjusting tube portion 11, so that the temperature measured by the second temperature measuring member 122 is the temperature of the whole blood sent from the left ventricle into the aorta.

In some implementations of the present application, the second temperature sensing member 122 includes a second thermistor disposed on an outer wall of the temperature sensing tube portion 12.

The thermistor is used as the second temperature measuring member 122, so that the second temperature measuring member 122 has higher sensitivity, and the temperature change of the aortic blood can be obtained more accurately.

The second thermistor may be connected to the outer wall of the temperature measuring tube 12 by a connection member such as a screw, a rivet, or the like, and may be adhered to the outer wall of the temperature measuring tube 12 by glue.

In some embodiments, the central axis of the temperature tube portion 11 intersects the central axis of the temperature tube portion 12, and the junction of the temperature tube portion 11 and the temperature tube portion 12 forms a kink structure 17, the kink structure 17 straddling the aortic valve 30.

By setting the central axis of the temperature-adjusting tube portion 11 and the central axis of the temperature-measuring tube portion 12 to intersect, the connection of the temperature-adjusting tube portion 11 and the temperature-measuring tube portion 12 is a bending connection, and the connection of the temperature-adjusting tube portion 11 and the temperature-measuring tube portion 12 forms a bending structure 17. When the fluid tube 1 is implanted in a heart of a human body, the temperature-regulating tube part 11 and the temperature-regulating tube part 12 are respectively positioned in the left ventricle and the aorta, and the bending structure 17 spans across the aortic valve 30, so that the possibility of moving the fluid tube 1 is reduced, and the positioning stability of the fluid tube 1 at the aortic valve 30 is improved.

In some embodiments of the present application, the temperature-adjusting tube portion 11 may refer to a structure of the fluid tube 1 located in the bending structure 17 away from the sheath tube portion 16, and may include a liquid filling port 19 provided with a liquid filling mechanism, a tube body provided with the suction port 13, and an introduction tube portion 15. When the fluid tube 1 is mounted on the heart, the temperature adjustment tube portion 11 may refer to a structure located in the left ventricle of the fluid tube 1.

The temperature measuring tube portion 12 may refer to a structure of the fluid tube 1 located at the bending structure 17 and away from the introduction tube portion 15, and may include a tube body provided with a first temperature measuring member 121, a tube body provided with a second temperature measuring member 122, and a tube body provided with the outflow port 14, and a sheath tube portion 16. When the fluid tube 1 is mounted on the heart, the temperature measuring tube portion 12 may be a structure of the fluid tube 1 located in the aorta.

In some implementations of the present application, the filling mechanism includes a filling device, a filling channel is provided on the fluid tube 1, a liquid inlet of the filling channel is connected to the filling device, and the filling mechanism fills the target object with the liquid for changing the blood temperature through a liquid outlet of the filling channel.

The liquid injector may be a device capable of generating pressure on the liquid and flowing the liquid in a predetermined direction. The injector can be perfusion equipment, an injector or an injection pump, and the type of the injector can be selected by a person skilled in the art according to actual situations, so long as the injector can intermittently or continuously fill liquid into the left ventricle.

The liquid filling channel may refer to a channel communicated between the liquid injector and the liquid filling port 19 of the liquid filling mechanism, and can guide the liquid conveyed by the liquid injector to the liquid filling port 19 of the liquid filling mechanism, so that the liquid conveyed by the liquid injector can flow out at a set position, which is beneficial to controlling the position of liquid filling.

In some embodiments, the fluid tube 1 is provided with a filling tube 2, and a filling channel is formed inside the filling tube 2.

The filling pipe 2 may refer to a pipe body capable of having an intermediate cavity, and the intermediate cavity of the filling pipe 2 may serve as a filling channel. One end of the liquid filling pipe 2 is connected to the liquid filling device, and a liquid filling port 19 as a liquid filling mechanism at the other end thereof may be arranged inside the temperature adjustment pipe portion 11 or outside the temperature adjustment pipe portion 11 to fill the inside of the temperature adjustment pipe portion 11 or outside the temperature adjustment pipe portion 11 with liquid.

In some embodiments, the filling pipe 2 is located inside the fluid pipe 1, and the pipe wall of the filling pipe 2 is connected to the inner wall of the fluid pipe 1.

The liquid injection pipe 2 is arranged in the fluid pipe 1, so that the liquid injection pipe 2 can be conveniently and synchronously implanted into a human body along with the fluid pipe 1, the influence of the liquid injection pipe 2 on the appearance of the fluid pipe 1 is reduced, and the damage to the target blood vessel 20 and cardiac muscle of the human body caused by the implantation of the fluid pipe 1 is reduced.

The pipe wall of the liquid injection pipe 2 can be connected to the inner wall of the fluid pipe 1 through connecting members such as screws and rivets, and can be adhered to the inner wall of the fluid pipe 1 through glue, and a person skilled in the art can select a connection mode of the pipe wall of the liquid injection pipe 2 and the inner wall of the fluid pipe 1 according to actual situations.

In some embodiments, as shown in fig. 3 and 4, a flow passage 18 is provided in the wall of the fluid tube 1, the flow passage 18 forming a liquid charging passage.

The flow passage 18 may refer to a cavity having a certain length formed by removing material in the wall of the fluid pipe 1, which can be used as a filling passage, one end of the flow passage 18 is connected to the filling machine, and a filling port 19 having the other end as a filling mechanism may be arranged inside the temperature adjustment pipe portion 11 or outside the temperature adjustment pipe portion 11 to fill the inside of the temperature adjustment pipe portion 11 or outside the temperature adjustment pipe portion 11 with liquid.

Some embodiments of the present application further provide a cardiac blood flow assist system, which includes the pump-catheter assembly provided in the above technical solution and a controller, wherein the controller is electrically connected with the filling mechanism and the temperature measuring tube portion 12 through a cable, the controller is configured to control the filling mechanism to fill the left ventricle with liquid, the controller is configured to control the temperature measuring tube portion 12 to measure the temperature, and the controller is configured to calculate the cardiac output according to the temperature measured by the temperature measuring tube portion 12.

In this embodiment, the controller may be a centralized or distributed controller, for example, the controller may be a single-chip microcomputer, or may be a distributed multi-chip microcomputer, where a control program may be run in the single-chip microcomputer, so as to control the temperature-adjusting tube portion 11 and the temperature-measuring tube portion 12 to implement functions thereof.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the embodiments, and are intended to be included within the scope of the claims and description. In particular, the technical features mentioned in the respective embodiments may be combined in any manner as long as there is no structural conflict. The present application is not limited to the specific embodiments disclosed herein, but encompasses all technical solutions falling within the scope of the claims.

Claims (15)

1. A pump-catheter assembly, comprising:

the fluid pipe comprises a temperature-regulating pipe part and a temperature-measuring pipe part, a suction inlet and a discharge outlet which are communicated are arranged on the fluid pipe at intervals, and the suction inlet and the discharge outlet are respectively positioned on the temperature-regulating pipe part and the temperature-measuring pipe part;

a liquid filling mechanism, a liquid filling port of which is positioned at the temperature-adjusting pipe part, wherein the liquid filling mechanism is configured to fill a liquid for changing the temperature of blood into a target object, the temperature-measuring pipe part is configured in a target blood vessel communicated with the target object, and the temperature-measuring pipe part is used for measuring the temperature of the blood; wherein the target object is one of a ventricle, an atrium, an superior vena cava, and an inferior vena cava;

and a liquid pump disposed in the fluid tube between the suction port and the outflow port for pumping blood from the target subject into the target blood vessel.

2. The pump-catheter assembly of claim 1, wherein a first temperature sensing member is disposed within the temperature sensing tube portion, the first temperature sensing member being located on a side of the outflow port proximate the temperature sensing tube portion.

3. The pump-catheter assembly of claim 2, wherein a fill port of the fill mechanism is disposed within the temperature tube portion, the fill port being located on a side of the suction port adjacent the temperature tube portion.

4. The pump-catheter assembly of claim 2, wherein the first temperature measurement member comprises a first thermistor coupled to an inner wall of the temperature measurement tube portion.

5. A pump-catheter assembly according to claim 1 or 2, wherein a second temperature measuring member is provided outside the temperature measuring tube portion, the second temperature measuring member being located on a side of the outflow opening remote from the temperature adjusting tube portion.

6. The pump-catheter assembly of claim 5, wherein a fill port of the fill mechanism is disposed outside of the temperature tube portion.

7. The pump-catheter assembly of claim 6, wherein an end of the temperature-regulating tube portion remote from the temperature-measuring tube portion is provided with an introduction tube portion, and wherein a filling port of the filling mechanism is provided in the introduction tube portion.

8. The pump-conduit assembly of claim 7, wherein the inlet tube portion is provided with an arcuate structure at an end of the inlet tube portion remote from the temperature-regulating tube portion.

9. The pump-catheter assembly of claim 5, wherein a sheath portion is provided on the temperature measurement tube portion at a location remote from the outflow port, and the second temperature measurement member is provided outside the sheath portion.

10. The pump-catheter assembly of claim 5, wherein the second temperature measurement member comprises a second thermistor disposed on an outer wall of the temperature measurement tube portion.

11. The pump-catheter assembly of claim 1, wherein the fluid-filling mechanism comprises a fluid-filling device, a fluid-filling channel is provided on the fluid tube, a fluid inlet of the fluid-filling channel is communicated with the fluid-filling device, and the fluid-filling mechanism fills the target object with the liquid for changing the temperature of the blood through a fluid outlet of the fluid-filling channel.

12. The pump-catheter assembly of claim 11, wherein a fill tube is disposed on the fluid tube, the interior of the fill tube defining the fill channel.

13. The pump-catheter assembly of claim 12, wherein the infusion tube is located inside the fluid tube.

14. The pump-catheter assembly of claim 11, wherein a flow channel is provided in a wall of the fluid tube, the flow channel forming the fluid-filled channel.

15. A heart blood flow assist system, comprising:

a pump-catheter assembly according to any one of claims 1 to 14;

and the controller is electrically connected with the temperature measuring tube part and the liquid filling mechanism, is configured to control the liquid filling mechanism to fill the liquid into the target object, is configured to control the temperature measuring tube part to measure temperature, and is configured to calculate cardiac output according to the temperature measured by the temperature measuring tube part.