CN117724145A - Method and device for acquiring activity of planar applicator, electronic equipment and storage medium - Google Patents
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- 230000000694 effects Effects 0.000 title claims abstract description 149
- 238000000034 method Methods 0.000 title claims abstract description 57
- 238000005259 measurement Methods 0.000 claims abstract description 39
- 239000007788 liquid Substances 0.000 claims description 38
- 238000004590 computer program Methods 0.000 claims description 13
- 229930182555 Penicillin Natural products 0.000 claims description 10
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 10
- 229940049954 penicillin Drugs 0.000 claims description 10
- 230000000977 initiatory effect Effects 0.000 claims description 8
- 238000009206 nuclear medicine Methods 0.000 abstract description 4
- OAICVXFJPJFONN-OUBTZVSYSA-N Phosphorus-32 Chemical compound [32P] OAICVXFJPJFONN-OUBTZVSYSA-N 0.000 description 13
- 229940097886 phosphorus 32 Drugs 0.000 description 13
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- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 159000000000 sodium salts Chemical class 0.000 description 4
- 230000005461 Bremsstrahlung Effects 0.000 description 3
- 229940100688 oral solution Drugs 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
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- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 description 1
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- 201000011066 hemangioma Diseases 0.000 description 1
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- 210000001117 keloid Anatomy 0.000 description 1
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention belongs to the field of nuclear medicine, and provides a method and a device for acquiring activity of a plane applicator, electronic equipment and a storage medium, wherein the method comprises the following steps: measuring the activity of the planar applicator to be measured by using a well-type activity meter to obtain a measured value; after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity; wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state. According to the method, the calibration factors are obtained firstly, and then the measured value obtained by direct measurement by using the well-type activity meter is calibrated, so that the more accurate activity of the plane applicator is obtained.
Description
Technical Field
The present invention relates to the technical field of nuclear medicine, and in particular, to a method and apparatus for acquiring activity of a planar applicator, an electronic device, and a storage medium.
Background
Phosphorus-32 applicators are used in the nuclear medicine department for the treatment of diseases such as hemangiomas, neurodermatitis, keloids and the like, and a common manufacturing method is a filter paper method. Phosphorus-32 belongs to the pure beta radionuclide and the resulting applicator can be considered a planar beta radiation source. Radioactivity is an amount that characterizes how much radioactivity is contained, and the activity of a clinically self-made applicator is typically estimated, i.e., the activity of the planar source produced is estimated from the volume and specific activity of the feed solution administered, and then the dose applied is calculated from the activity and dose relationship. However, the activity is estimated by feeding, the decay activity needs to be continuously corrected, and the activity measurement deviation may be larger due to sampling errors and calculation errors.
Currently, there is a lack of a simple and accurate method for measuring the activity of a planar applicator during clinical application. On the one hand, the methods for measuring the absolute activity of the planar beta source include a 4 pi counting method, a beta-gamma conforming method, a liquid flashing method and the like, but the methods have the defects of expensive equipment, complicated measuring method and inapplicability to clinical application. On the other hand, the well-type activity meter used in clinic is measured according to the principle that the current formed by gamma rays and ionization is in direct proportion to the activity of nuclides, and the activity of the pure beta-ray nuclides is measured according to the fact that the ionization current of bremsstrahlung generated by beta rays and a medium is in direct proportion to the activity, and the carrier shape and the holding container of the nuclides are required to be consistent, otherwise, larger errors are generated. Beta nuclides are measured using well-type activity meters and are generally only suitable for high energy beta nuclide (e.g., phosphorus-32, yttrium-90) activity measurements in solution in standard bottles (penicillin bottles or penicillin bottles). Changing the carrier morphology of nuclides, such as bottled liquid to solid filter paper plane source, can cause bremsstrahlung deviation, and simultaneously, the change of the measurement angle can also cause larger measurement error, so that the activity of the plane applicator can not be accurately obtained.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides a method, a device, electronic equipment and a storage medium for acquiring the activity of a plane applicator.
In a first aspect, the present invention provides a method of obtaining the activity of a planar applicator, comprising the steps of:
measuring the activity of the planar applicator to be measured by using a well-type activity meter to obtain a measured value;
after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity;
wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
Further, the number of the sample plane applicators is a plurality, the measuring state of the sample plane applicators is consistent with the measuring state of the plane applicators to be measured, during the measuring process, the positions of each plane applicator in the ionization chamber of the well-type activity meter are consistent, and the carrier and the outer wrapper of each plane applicator are the same.
Further, the method comprises the steps of,
when the area of the planar applicator is 18cm or less 2 The length and the width are smaller than 6cm, and the plane applicator is placed at the bottom of the ionization chamber of the well-type activity meter in a horizontal state;
when the area of the planar applicator is greater than 18cm 2 And the length-width ratio is more than or equal to 1, the width is less than 6cm, and the plane applicator is arranged in the ionization chamber of the well-type activity meter in an upright state;
when the area of the planar applicator is greater than 18cm 2 And the length and width are both greater than 6cm and less than 18.8cm, the planar applicator is placed in a curved state on one side of the ionization chamber of the well-type activity meter.
Further, the obtaining of the true value of the sample plane applicator includes:
taking a feed liquid with a certain activity, filling the feed liquid into a penicillin bottle, measuring the activity, and recording the obtained data as an initial activity;
a sampler is used for taking part of feed liquid and dripping the part of feed liquid onto an applicator carrier, so as to prepare a sample plane applicator;
and measuring the activity of the residual feed liquid, and recording the obtained data as the residual activity, wherein the difference between the initial activity and the residual activity is the true value of the sample plane applicator.
Further, in the process of acquiring the true value of the sample plane applicator, a well-type activity meter is adopted for measuring the activity;
in the step of measuring the activity of the residual feed liquid, the residual feed liquid comprises the feed liquid remained in the penicillin bottle and the feed liquid remained in the sampler.
Further, the applicator carrier is square filter paper with a thickness of not more than 0.5mm.
Further, the measurement of the sample plane applicator is measured by a well-type activity meter.
In a second aspect, the present invention provides a planar applicator activity acquisition device comprising:
the measured value acquisition module is used for measuring the activity of the plane applicator to be measured by using the well-type activity meter to obtain a measured value;
a target value acquisition module for acquiring the activity of the target plane applicator after the measured value is calibrated by a calibration factor;
wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
In a third aspect, the present invention provides an electronic device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, the processor implementing any of the above-described planar applicator activity acquisition methods when executing the program.
In a fourth aspect, the present invention provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements any of the above-described planar applicator activity acquisition methods.
In a fifth aspect, the present invention also provides a computer program product comprising a computer program which when executed by a processor implements a method of obtaining the activity of a flat applicator as described in any of the above.
The invention provides a method, a device, electronic equipment and a storage medium for acquiring the activity of a plane applicator, which are used for acquiring a calibration factor firstly and then calibrating a measured value directly measured by a well type activity meter so as to acquire more accurate activity of the plane applicator.
Drawings
In order to more clearly illustrate the invention or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a flow chart of a method for acquiring the activity of a flat applicator provided by the invention;
FIG. 2 is a schematic diagram of the structure of the activity acquisition device of the flat applicator provided by the present invention;
fig. 3 is a schematic structural diagram of an electronic device provided by the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The following describes embodiments in detail based on the flat applicator activity acquisition method according to the present invention. As shown in fig. 1, which is a schematic flow chart of the method for obtaining the activity of the flat applicator, the specific implementation process includes the following steps:
step 101: the activity of the planar applicator to be measured is measured using a well-type activity meter to obtain a measurement value.
In some embodiments of the invention, when the area of the planar applicator to be tested is 18cm or less 2 The length and the width are smaller than 6cm, and the plane applicator to be tested is placed at the bottom of the ionization chamber of the well-type activity meter in a horizontal state;
when the area of the planar applicator to be tested is greater than 18cm 2 And the length-width ratio is more than or equal to 1, the width is less than or equal to 6cm, and the plane applicator to be tested is arranged in an ionization chamber of the well-type activity meter in an upright state;
when the area of the planar applicator to be tested is greater than 18cm 2 And the length and the width are more than 6cm and less than 18.8cm, and the plane applicator to be tested is arranged at one side of the ionization chamber of the well-type activity meter in a bending state.
In some embodiments of the invention, the planar applicator to be tested is a phosphor-32 planar applicator. Further, the well-type activity meter used is a phosphorus-32 nuclide calibrated well-type activity meter.
Step 102: after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity; wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
In some embodiments of the invention, the obtaining of the true value of the sample plane applicator comprises:
taking a feed liquid with a certain activity, filling the feed liquid into a penicillin bottle, measuring the activity, and recording the obtained data as an initial activity;
a sampler is used for taking part of feed liquid and dripping the part of feed liquid onto an applicator carrier, so as to prepare a sample plane applicator;
and measuring the activity of the residual feed liquid, and recording the obtained data as the residual activity, wherein the difference between the initial activity and the residual activity is the true value of the sample plane applicator.
It will be appreciated that when the planar applicator to be tested is a phosphorus-32 planar applicator, then the sample planar applicator is also a phosphorus-32 planar applicator and the active liquid is a phosphorus-32 liquid, such as an oral solution of sodium salt of phosphorus [32P ] acid.
In some embodiments of the invention, the measurement activities are all measured using a well-type activity meter during the acquisition of the actual values of the sample plane applicator.
In some embodiments of the invention, in the step of measuring the activity of the residual feed liquid, the residual feed liquid comprises the feed liquid remaining in the penicillin bottle and the feed liquid remaining in the sampler, so that the residual error is reduced.
In some embodiments of the invention, the applicator carrier is a square filter paper having a thickness of no more than 0.5mm.
In order to reduce bremsstrahlung, materials with high atomic numbers, such as iron bottles, lead rubber, stainless steel cylinders, rigid plastic bodies with a thickness higher than 3mm, etc., are not used as carriers for the measurements. The same substrate filter paper material should be used, and the thickness is not more than 0.5mm. Further, the planar applicator is formed by wrapping a relatively thin plastic material to avoid direct contact of the radiation source with the human skin, and preferably the total thickness of the wrapped finished product is no more than 0.5mm.
In some embodiments of the invention, the measurement of the sample plane applicator is measured by a well activity meter. The specific method and operational considerations are the same as measuring the activity of the planar applicator to be tested using a well-type activity meter. And will not be described in detail herein.
It will be appreciated that for the accuracy of the measurement, the number of sample plane applicators is a plurality, theoretically the more good. In the measuring process, the measuring state of the sample plane applicator is consistent with that of the plane applicator to be measured, the position of each plane applicator in the ionization chamber of the well-type activity meter is consistent, and the carrier and the outer wrapper of each plane applicator are the same.
Specifically, the measurement states include a horizontal state, an upright state, and a curved state;
when the area of the planar applicator is 18cm or less 2 The length and the width are smaller than 6cm, and the plane applicator to be tested is placed at the bottom of the ionization chamber of the well-type activity meter in a horizontal state;
when the area of the planar applicator is greater than 18cm 2 And the length-width ratio is more than or equal to 1, the width is less than 6cm, and the plane applicator to be tested is arranged in an ionization chamber of the well-type activity meter in an upright state;
when the area of the planar applicator is greater than 18cm 2 And the length and the width are more than 6cm and less than 18.8cm, and the plane applicator to be tested is arranged at one side of the ionization chamber of the well-type activity meter in a bending state.
In some embodiments of the present invention, after obtaining the measured and actual values of the sample flat applicator, a linear or exponential relationship is obtained from the statistical tool, thereby obtaining three states of calibration factors, respectively. Further, the target planar applicator activity may be obtained after calibrating the measurement with a calibration factor. The numerical value is more accurate than the measured value directly measured by using the well-type activity meter, is more accurate than the activity estimated in the prior art, provides convenience for clinical nuclear medicine department operation, can calculate the radiation amount more accurately, and provides possibility for more accurate symptomatic medication.
It will be appreciated that the above method should be used for recalibration when the material changes or the angle of measurement changes.
In order to more clearly illustrate the method of obtaining the activity of the flat applicator provided by the present invention, a specific embodiment will be described below.
Example 1
Raw materials and equipment: phosphorus [32P ] acid sodium salt oral solution, manufactured by atomic Gaokou Co., ltd; CRC-55tR well activity meter.
1. Obtaining a true value for a sample plane applicator
(1) Standard size applicator carriers were prepared, such as 10mm x 10mm, 20mm x 20mm, 30mm x 30mm square filter papers (thickness no more than 0.5 mm).
(2) Using a calibrated well activity meter (phosphorus-32 nuclide calibration), if not calibrated, reference is made to the following relative method.
Relative method calibration: the standard solution of phosphorus-32 or the standard commodity of the sodium salt of phosphorus [32P ] acid is needed, the oral solution of sodium salt of phosphorus [32P ] acid produced in atomic high-yield is taken as an example, the radioactivity and the calibration time of factory mark are taken as references, and whether the phosphorus 32 grade of the activity meter works normally is measured.
(3) Taking phosphorus-32 feed liquid with certain activity, filling the phosphorus-32 feed liquid into a penicillin bottle, measuring the activity by using a well type activity meter, and recording the activity as the initial activity.
(4) And (3) sampling the phosphorus-32 feed liquid by using a sampler (or a micro-sample needle), uniformly dripping the sample liquid onto the filter paper, naturally adsorbing the dripped sample liquid in the middle of the filter paper without exudation, and naturally drying the edge of the filter paper in a suspended manner or in a windless environment. At this point a sample plane applicator is obtained. In the same way, a plurality of sample plane applicators are obtained.
(5) The activity of the residual feed liquid is measured by a well-type activity meter, and the residual feed liquid is measured together with a sampling needle during measurement, so that the residual error is reduced. The residual activity is subtracted from the initial activity to yield a true value for the sample flat applicator.
2. Obtaining measurements of a sample plane applicator
The activity of the sample flat applicator was measured with a well-type activity meter to obtain a measurement value.
The same measuring state is kept during measurement, such as a horizontal state or an upright state, or a bending state; the planar applicator is positioned the same as in the middle position in the ionization chamber of the activity meter during measurement; while ensuring that the planar applicator is overwrapped or otherwise carried the same, such as a thin PE bag, or placed in the same penicillin bottle.
3. Based on the actual and measured values of the sample plane applicator, a statistical tool is used to obtain a linear or exponential relationship, and the calibration factors for the three measurement states are obtained respectively.
4. The activity of the planar applicator to be measured is measured using a well-type activity meter to obtain a measurement value.
When the area of the planar applicator to be tested is 18cm or less 2 The length and the width are smaller than 6cm, and the plane applicator to be tested is placed at the bottom of the ionization chamber of the well-type activity meter in a horizontal state;
when the area of the planar applicator to be tested is greater than 18cm 2 And the length-width ratio is more than or equal to 1, the width is less than or equal to 6cm, and the plane applicator to be tested is arranged in an ionization chamber of the well-type activity meter in an upright state;
when the area of the planar applicator to be tested is greater than 18cm 2 And the length and the width are more than 6cm and less than 18.8cm, and the plane applicator to be tested is arranged at one side of the ionization chamber of the well-type activity meter in a bending state.
5. And selecting a corresponding calibration factor according to the measurement state of the plane applicator to be measured, and calibrating the measured value by using the calibration factor to obtain more accurate activity of the plane applicator to be measured.
Corresponding to the above provided method for obtaining the activity of the flat surface applicator, the invention also provides a device for obtaining the activity of the flat surface applicator. Since the device embodiments are similar to the method embodiments described above, the description is relatively simple, and reference should be made to the description of the method embodiments section above, and the embodiments of the planar applicator activity acquisition device described below are illustrative only.
Fig. 2 is a schematic structural diagram of an activity acquisition device for a flat panel applicator according to an embodiment of the present invention. Comprises the following parts:
a measurement value acquisition module 201, configured to measure an activity of a planar applicator to be measured using a well-type activity meter, to obtain a measurement value;
a target value acquisition module 202 for acquiring a target plane applicator activity after calibrating the measurement value with a calibration factor;
wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
Corresponding to the method for acquiring the activity of the plane applicator, the invention also provides electronic equipment. Since the embodiments of the electronic device are similar to the method embodiments described above, the description is relatively simple, and reference should be made to the description of the method embodiments described above, and the electronic device described below is merely illustrative. Fig. 3 is a schematic diagram of an entity structure of an electronic device according to an embodiment of the present invention. The electronic device may include: processor 310, communication interface (Communications Interface) 320, memory 330 and communication bus 340, wherein processor 310, communication interface 320, memory 330 accomplish communication with each other through communication bus 340. The processor 310 may invoke logic instructions in the memory 330 to perform a flat applicator activity acquisition method comprising: measuring the activity of the planar applicator to be measured by using a well-type activity meter to obtain a measured value; after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity; wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
Further, the logic instructions in the memory 330 described above may be implemented in the form of software functional units and may be stored in a computer-readable storage medium when sold or used as a stand-alone product. Based on this understanding, the technical solution of the present invention may be embodied essentially or in a part contributing to the prior art or in a part of the technical solution, in the form of a software product stored in a storage medium, comprising several instructions for causing a computer device (which may be a personal computer, a server, a network device, etc.) to perform all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a random access Memory (RAM, random Access Memory), a magnetic disk, or an optical disk, or other various media capable of storing program codes.
In another aspect, the present invention also provides a computer program product, the computer program product comprising a computer program, the computer program being storable on a non-transitory computer readable storage medium, the computer program, when executed by a processor, being capable of executing the planar applicator activity obtaining method provided by the above methods, the method comprising: measuring the activity of the planar applicator to be measured by using a well-type activity meter to obtain a measured value; after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity; wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
In yet another aspect, the present invention also provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, is implemented to perform the planar applicator activity acquisition method provided by the above methods, the method comprising: measuring the activity of the planar applicator to be measured by using a well-type activity meter to obtain a measured value; after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity; wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
The apparatus embodiments described above are merely illustrative, wherein the elements illustrated as separate elements may or may not be physically separate, and the elements shown as elements may or may not be physical elements, may be located in one place, or may be distributed over a plurality of network elements. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment. Those of ordinary skill in the art will understand and implement the present invention without undue burden.
From the above description of the embodiments, it will be apparent to those skilled in the art that the embodiments may be implemented by means of software plus necessary general hardware platforms, or of course may be implemented by means of hardware. Based on this understanding, the foregoing technical solution may be embodied essentially or in a part contributing to the prior art in the form of a software product, which may be stored in a computer readable storage medium, such as ROM/RAM, a magnetic disk, an optical disk, etc., including several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the method described in the respective embodiments or some parts of the embodiments.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A method of obtaining the activity of a planar applicator, comprising the steps of:
measuring the activity of the planar applicator to be measured by using a well-type activity meter to obtain a measured value;
after calibrating the measured value with a calibration factor, obtaining a target planar applicator activity;
wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
2. The method of claim 1, wherein the number of sample flat applicators is a plurality, the measurement state of the sample flat applicators is identical to the measurement state of the flat applicators to be measured, each flat applicator is positioned in the ionization chamber of the well-type activity meter during the measurement, and the carrier and the outer wrapper of each flat applicator are identical.
3. The planar applicator activity acquisition method as claimed in claim 2, wherein,
when the area of the planar applicator is 18cm or less 2 The length and the width are smaller than 6cm, and the plane applicator is placed at the bottom of the ionization chamber of the well-type activity meter in a horizontal state;
when the area of the planar applicator is greater than 18cm 2 And the aspect ratio is more than or equal to 1, the width is less than or equal to 6cm, the plane applicator is arranged in the ionization chamber of the well-type activity meter in an upright state;
when the area of the planar applicator is greater than 18cm 2 And the length and width are both greater than 6cm and less than 18.8cm, the planar applicator is placed in a curved state on one side of the ionization chamber of the well-type activity meter.
4. The method of planar applicator activity acquisition according to any one of claims 1 to 3, wherein the acquisition of the true value of the sample planar applicator comprises:
taking a feed liquid with a certain activity, filling the feed liquid into a penicillin bottle, measuring the activity, and recording the obtained data as an initial activity;
a sampler is used for taking part of feed liquid and dripping the part of feed liquid onto an applicator carrier, so as to prepare a sample plane applicator;
and measuring the activity of the residual feed liquid, and recording the obtained data as the residual activity, wherein the difference between the initial activity and the residual activity is the true value of the sample plane applicator.
5. The method of claim 4, wherein the measuring activities are performed by a well-type activity meter during the obtaining of the actual values of the sample flat applicator;
in the step of measuring the activity of the residual feed liquid, the residual feed liquid comprises the feed liquid remained in the penicillin bottle and the feed liquid remained in the sampler.
6. The method of claim 4, wherein the applicator carrier is a square filter paper having a thickness of no more than 0.5mm.
7. A method of obtaining the activity of a planar applicator according to any one of claims 1 to 3, wherein the sample planar applicator measurement is measured by a well-type activity meter.
8. A planar applicator activity acquisition device, comprising:
the measured value acquisition module is used for measuring the activity of the plane applicator to be measured by using the well-type activity meter to obtain a measured value;
a target value acquisition module for acquiring the activity of the target plane applicator after the measured value is calibrated by a calibration factor;
wherein the calibration factor is obtained based on the measured value and the actual value of the sample plane applicator, and the calibration factor differs according to the measurement state, which is divided into a horizontal state, an upright state, and a curved state.
9. An electronic device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor implements the planar applicator activity acquisition method of any one of claims 1 to 7 when the program is executed by the processor.
10. A non-transitory computer readable storage medium having stored thereon a computer program, wherein the computer program when executed by a processor implements the planar applicator activity acquisition method of any one of claims 1 to 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410172446.6A CN117724145B (en) | 2024-02-07 | 2024-02-07 | Method and device for acquiring activity of planar applicator, electronic equipment and storage medium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410172446.6A CN117724145B (en) | 2024-02-07 | 2024-02-07 | Method and device for acquiring activity of planar applicator, electronic equipment and storage medium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117724145A true CN117724145A (en) | 2024-03-19 |
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