CN117682986A - Synthesis method of beta-pyridone derivative - Google Patents

Synthesis method of beta-pyridone derivative Download PDF

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CN117682986A
CN117682986A CN202311699867.6A CN202311699867A CN117682986A CN 117682986 A CN117682986 A CN 117682986A CN 202311699867 A CN202311699867 A CN 202311699867A CN 117682986 A CN117682986 A CN 117682986A
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alkyl
aryl
hydrogen
independently
chloroform
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黎婉婷
曾亮
欧阳旋慧
姜雪峰
李金恒
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Nanchang Hangkong University
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Nanchang Hangkong University
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Abstract

The invention discloses a synthesis method of beta-pyridone derivative, which is based on 1- (o-iodo-aryl) alkane-1-ketone induced by iodo-arene and photocatalysis beta-C (sp) of cyano-arene through halogen atom transfer (XAT) and Hydrogen Atom Transfer (HAT) 3 ) H arylation involving diethylaminoethyl radical mediated aryl intermediate production followed by directing 1,5-HAT to form distal alkyl radical intermediate and coupling with cyanoarene (corresponding cyanoarene radical intermediate produced by photoreduction), and is suitable for a wide range of inactive remote C (sp 3 ) The H bond provides a brand new synthetic approach for constructing and obtaining the beta-pyridone derivative. The method can be carried out at room temperature, the reaction condition is mild and simple, the substrate application range is wide, and the target product yield is high.

Description

Synthesis method of beta-pyridone derivative
Technical Field
The application belongs to the technical field of medicine synthesis, and in particular relates to a synthesis method of a beta-pyridone derivative
Background
The beta-pyridone derivative has wide application in the fields of medicine, agricultural chemistry and organic synthesis. For example, WO2006/041037A1 disclosesPyridine derivatives having the following formula (1) are obtained,wherein A represents a substituted phenyl or naphthyl group, X represents an O atom, R1 to R4 are hydrogen or lower alkyl groups, etc., indicating that the class of beta-pyridone derivatives are useful as therapeutic agents, particularly as C17-20 lyase inhibitors. In the patent document, the method for preparing the pyridine derivative has two ways, namely, aromatic ketone is used as a raw material, the aromatic ketone is firstly converted into enolate, then aldol reaction is carried out on the enolate and pyridine-4-ketone compound, and the target product is obtained through dehydration elimination and catalytic hydrogenation; and secondly, taking aromatic ketone as a raw material, performing aldol condensation with pyridine-4-formaldehyde, and then dehydrating, eliminating and double bond adding to obtain a target product. The method has the advantages of long synthetic route, high reaction cost and low total yield, and is not suitable for industrial production. Therefore, the development of a convenient method for synthesizing the beta-pyridone derivative has important practical significance.
Jiangwei Wen et al reported site-selective hydropyridylations of alkynones/enones under electrocatalytic conditions to produce β -pyridones (org.chem.front., 2023,10,193-202; adv.synth.catalyst.2022, 364, 845-854); zhiyong Jiang et al reported the catalytic asymmetric reduction of aza arylation reactions of enacetones with 4-cyanopyridine via enantioselective free radical coupled olefins under DPZ, phosphate ligand, HE-1 and light conditions to produce β -pyridones (j.am.chem.soc., 2022,144,7805-7814). The MacMillan group reports that beta-C (sp 3) -H arylation of ketones and aldehydes was achieved by radical-radical coupling using synergistic photooxidation reduction and enamine catalysis with electron-deficient cyanoarenes as aryl coupling agents, under radical mediation, thus constructing beta-aryl ketones and aldehydes (Science, 2013,339,1593-1596). Although these methods are highly efficient, they require a reaction substrate of a specific structure to be designed in advance, and are not highly versatile.
The modification of inert C (sp 3) -H bonds to purposefully increase the degree of molecular complexation, and the modification of abundant hydrocarbonaceous feedstocks into valuable compounds, is an important topic of research in the field of pharmaceutical synthesis. In contrast to the widely studied arylation of C (sp 3) -H bonds in the α -position in carbonyl compounds, the direct arylation of C (sp 3) -H bonds in the β -position or more in carbonyl compounds is largely imperfect and remains a great challenge in site-selective control due to competing reactions, such as the more acidic arylation of α -C (sp 3) -H bonds. In the present invention, it was first reported that ortho-iodoaryl alkanones are directly β -C-H arylated with cyano (hetero) arenes by a visible light mediated photo-redox halogen atom transfer (XAT) and 1, 5-Hydrogen Atom Transfer (HAT) process, wherein photo-reduction/deprotonation of triethylamine produces diethylaminoethyl radicals, which are used as halogen atom transfer agents for activating aryl iodides to undergo XAT and produce aryl radicals, followed by orientation of 1,5-HAT to provide remote β -sp 3-carbon center radical and radical-radical coupling. The iodo arene oriented HAT strategy is applicable to beta-C (sp 3) -H arylation of alkanols and derivatives thereof, distal C (sp 3) -H arylation of alkanes or alkyl ethers and alpha-C (sp 3) -H arylation of esters for assembling a variety of functionalized arenes and heteroarenes, particularly for preparing series of beta-pyridone derivatives.
Disclosure of Invention
The invention aims to provide a novel synthesis method of beta-pyridone derivatives, which uses o-iodoaryl alkanone and cyano (hetero) arene to directly carry out beta-C-H arylation through a visible light-mediated photooxidation reduction halogen atom transfer (XAT) and 1, 5-Hydrogen Atom Transfer (HAT) process, and has the advantages of mild and simple reaction conditions, easily obtained raw materials, wide substrate application range, high target product yield and the like.
The synthesis method of the beta-pyridone derivative provided by the invention comprises the following steps:
adding a compound shown in a formula 1, a compound shown in a formula 2, a photocatalyst, organic amine, alkali and an organic solvent into a reactor, replacing the atmosphere in the reactor with an inert atmosphere, stirring and reacting at room temperature under the condition of illumination, and purifying after the reaction is completed to obtain a beta-pyridone derivative shown in a formula 3; the reaction formula is as follows:
in the above reaction formula, m and n are integers of 1, 2,3 or 4.
Each R is 1 The same or different, independently of one another, are selected from hydrogen, halogen, CN, C 1-20 Alkyl, halogenated C 1-20 Alkyl, C 1-20 An alkoxy group.
Represents a double bond, a single bond or the absence thereof; y is selected from O, S, OR a Or is absent; wherein R is a Is hydrogen, C 1-20 Alkyl, C 1-20 An acyl group.
Z is selected from CH 2 O or S.
R 2 ,R 3 Independently of one another selected from hydrogen, C 1-20 Alkyl, C 6-20 Aryl, C 6-20 aryl-C 1-20 Alkyl, substituted C 6-20 Aryl, or R 2 ,R 3 Are connected to each other and to the connection R 2 ,R 3 Together form C 3-8 A meta cyclic group; wherein the substituted C 6-20 The substituents of the aryl groups being selected from halogen, C 1-6 Alkyl, C 1-6 An alkoxy group; provided that R 2 ,R 3 Not simultaneously selected from hydrogen.
X is selected from N or CR b The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is b Is electron withdrawing group selected from CN, NO 2 、CF 3 、-COOR c 、-SO 2 R d The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is c ，R d Independently selected from C 1-6 Alkyl, C 6-20 Aryl groups.
Each R is 4 The same or different, independently of one another, are selected from hydrogen, halogen, CN, C 1-20 Alkyl, halogenated C 1-20 Alkyl, C 1-20 Alkoxy, C 6-20 Aryl, C 2-20 Heteroaryl, substituted C 6-20 Aryl, C 6-20 Aryl ethynyl; wherein the substituted C 6-20 The substituents of the aryl groups being selected from halogen, C 1-6 Alkyl, C 1-6 An alkoxy group.
Preferably, m, n are integers of 1 or 2.
Each R is 1 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, bromine, iodine, CN, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 An alkoxy group.
Represents a double bond, a single bond or the absence thereof; y is selected from O, S, OR a Or is absent; wherein R is a Is hydrogen, C 1-6 Alkyl, C 1-20 An acyl group.
Z is selected from CH 2 O or S.
R 2 ,R 3 Independently of one another selected from hydrogen, C 1-10 Alkyl, C 6-14 Aryl, C 6-14 aryl-C 1-6 Alkyl, substituted C 6-14 Aryl, or R 2 ,R 3 Are connected to each other and to the connection R 2 ,R 3 Together form C 3-8 A membered carbocyclic group; wherein the substituted C 6-14 The substituents of the aryl groups being selected from fluorine, chlorine, bromine, iodine, C 1-6 Alkyl, C 1-6 An alkoxy group; provided that R 2 ,R 3 Not simultaneously selected from hydrogen.
X is selected from N or CR b The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is b Is electron withdrawing group selected from CN, NO 2 、CF 3 、-COOR c 、-SO 2 R d The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is c ，R d Independently selected from C 1-6 Alkyl, C 6-20 Aryl groups.
Each R is 4 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, bromine, iodine, CN, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, C 6-14 Aryl, C 2-14 Heteroaryl, substituted C 6-14 Aryl, C 6-14 Aryl ethynyl; wherein the substituted C 6-14 The substituents of the aryl groups being selected from fluorine, chlorine, bromine, iodine, C 1-6 Alkyl, C 1-6 An alkoxy group.
Further preferably, m, n are integers of 1 or 2.
Each R is 1 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, methyl, methoxy, trifluoromethyl.
Represents a double bond, a single bond or the absence thereof; y is selected from O, S, OR a Or is absent; wherein R is a Is hydrogen, acetyl,
Z is selected from CH 2 O or S.
R 2 ,R 3 Independently of one another, selected from hydrogen, methyl, ethyl, isopropyl, n-propyl, n-decyl, phenyl, benzyl, phenethyl, p-methylphenyl, or R 2 ,R 3 Are connected to each other and to the connection R 2 ,R 3 Together form a cyclohexyl group.
X is selected from N or CR b The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is b Is an electron withdrawing group selected from CN, -COOR c 、-SO2R d The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is c ，R d Independently selected from methyl.
Each R is 4 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, bromine, iodine, CN, methyl, ethyl, methoxy, phenyl, phenylethynyl, thienyl, p-methoxyphenyl, p-chlorophenyl.
The photocatalyst is selected from fac-Ir (ppy) 3 Or Ir (ppy) 2 (dtbbpy)PF 6 Any one of them; preferably fac-Ir (ppy) 3 。
The organic amine is selected from any one of triethylamine or diisopropylethylamine, preferably triethylamine.
The organic base is selected from NaOAc, KOAc, K 2 CO 3 Or Na (or) 2 CO 3 Any one or more of these are preferably NaOAc.
The organic solvent is selected from one or more of DMSO, DMF, NMP and acetonitrile, and is preferably DMSO.
Herein, the C 1-20 Alkyl is preferably C 1-12 Alkyl, more preferably C 1-6 An alkyl group. As examples of the aforementioned alkyl group, it may be selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, undecyl, dodecyl and the like. Herein, the alkoxy, haloalkyl, C 6-20 aryl-C 1-20 The alkyl groups in the alkyl groups have the same definition as the aforementioned alkyl groups.
Herein, the C 1-20 Acyl refers to an acyl group having 1 to 20 carbon atoms, which may be linear, branched or cyclic, which may be saturated or unsaturated, preferably without other atoms. Exemplary acyl groups may be acetyl, propionyl,Etc.
Herein, C as described 6-20 Aryl, substituted C 6-20 The aryl group in the aryl group is preferably C 6-14 Aryl, exemplary aryl groups are phenyl, naphthyl, anthracenyl, phenanthrenyl, indenyl, fluorenyl, and the like. Herein, the C 6-20 aryl-C 1-20 Alkyl, C 6-20 Aryl groups in the arylethynyl group have the same definition as the aryl groups previously described.
Herein, C as described 2-20 Heteroaryl, C 2-20 Heteroaryl in heteroaryl is preferably C 2-14 Heteroaryl, exemplary heteroaryl groups such as thienyl, furyl, indolyl, pyridyl, quinolinyl, pyrimidinyl, benzothienyl, benzofuranyl, and the like.
According to the synthesis method of the invention, the feeding mole ratio of the compound shown in the formula 1, the compound shown in the formula 2, the photocatalyst, the organic amine and the alkali is 1 (0.8-1.2): 0.005-0.02): 1-3. Preferably, the compound shown in formula 1, the compound shown in formula 2, the photocatalyst, the organic amine and the base are fed in a molar ratio of 1:1:0.01:2:2.
according to the synthesis method of the present invention, the inert atmosphere is a nitrogen atmosphere or an argon atmosphere, preferably an argon atmosphere.
According to the synthesis method disclosed by the invention, the illumination condition is provided by a blue LED lamp with the wavelength of 3-30W, preferably an 18W blue LED lamp.
According to the aforementioned synthesis method of the present invention, the reaction time of the stirring reaction is 4 to 48 hours, preferably 8 to 24 hours, and more preferably 12 hours.
According to the aforementioned synthetic method of the present invention, the purification treatment comprises the following operations: the reaction solution was concentrated in vacuo, diluted with diethyl ether, washed with saturated brine, the organic phases were combined and dried over anhydrous sodium sulfate, and the residue was concentrated to give a beta-pyridone derivative represented by formula 3, which was separated by silica gel column chromatography.
Compared with the prior art, the method has the following remarkable advantages:
the present invention reports for the first time the photocatalytic beta-C (sp 3) -H arylation of iodo-arene-induced 1- (ortho-iodo-aryl) alkane-1-ones with cyano-arenes by halogen atom transfer (XAT) and Hydrogen Atom Transfer (HAT). The method involves diethylaminoethyl radical mediated aryl intermediate production, then directs the 1,5-HAT to form a distal alkyl radical intermediate, and couples with a cyanoarene (the corresponding cyanoarene radical intermediate produced by photoreduction), and is suitable for a wide range of inactive remote C (sp 3) -H bonds, providing a novel synthetic route for building and obtaining, for example, beta-pyridone derivatives.
The method can be carried out at room temperature, the reaction condition is mild and simple, the substrate application range is wide, and the target product yield is high.
Drawings
FIG. 1 is a diffraction pattern of a single crystal structure of Compound 3aa
FIG. 2 is a schematic diagram of the reaction mechanism of the present invention
Detailed Description
The present invention will be described in further detail with reference to specific examples. In the following, unless otherwise indicated, all procedures used are conventional in the art and reagents and starting materials used are commercially available from conventional commercial sources in the art and/or are prepared by conventional methods.
Preparation of reaction raw materials example 1
The mixture of 2-iodobenzaldehyde (50 mmol) and THF (50 mL) is cooled to 0 ℃ under the protection of nitrogen, corresponding Grignard reagent (1.5 eq) is added dropwise, the reaction mixture is stirred at 0 ℃ for reaction for 1.5-3 hours, then the mixture is quenched by saturated ammonium chloride, extracted by ethyl acetate, washed by saline (50 mL) and dried by anhydrous sodium sulfate, and benzyl alcohol intermediate A is obtained by silica gel column chromatography separation. To a solution of benzyl alcohol intermediate a (1 eq) in dichloromethane (0.1M), DMP (1.5 eq) was added at 0 ℃ and then the mixture was stirred at room temperature to react, after completion of the reaction, the mixture was filtered and extracted with ethyl acetate, concentrated and the residue was separated by silica gel column chromatography to give compound 1.
Preparation of reaction raw materials example 2
A mixture of NaH (60% suspension in mineral oil, 1.5-3 eq) and anhydrous THF (0.56M NaH concentration) was added to a dry round bottom flask, cooled to 0deg.C, a solution of 2-iodobenzyl alcohol (1 eq) in anhydrous THF (0.78M) was added dropwise and stirred for 2 hours, then the corresponding bromide (1.1-1.7 eq) was added dropwise, stirred for 2-16 hours at room temperature, the reaction was monitored by TLC to completion, quenched with saturated ammonium chloride or H2O (20 mL) at 0deg.C, extracted with ethyl acetate, the organic phases were combined and washed with brine, dried over sodium sulfate, filtered, concentrated in vacuo, and the residue was separated by silica gel column chromatography to give the corresponding compound 2.
Examples 1 to 19 reaction condition optimization experiments
The compound shown in formula 1a and p-cyanopyridine shown in formula 2a are used as raw materials, and the beta-pyridone derivative shown in formula 3aa is prepared by photocatalysis of beta-C (sp 3) -H arylation through halogen atom transfer (XAT) and Hydrogen Atom Transfer (HAT), and the influence of different synthesis conditions on the yield of a target product is studied, and the result is as follows
Table 1 shows the following reaction scheme:
table 1:
a standard reaction conditions 1a (0.2 mmol), 2a (0.2 mmol), fac-Ir (ppy) 3 (1mol％),Et 3 N (2 equiv), naOAc (2 equiv), DMSO (0.1M; 2 mL), 18W blue LEDs, argon, room temperature, reaction time 12h; b 1a(1mmol)and 24h。
taking example 1 as an example, a typical test procedure is as follows:
into a Schlenk tube reactor was charged compound 1a (0.2 mmol), 2a (0.2 mmol,1 eq), fac-Ir (ppy) 3 (1mol％),Et 3 N (2 equiv), naOAc (2 equiv), DMSO (2 mL, 0.1M), then the reactor was placed under argon for three times, the reactor was stirred for 12 hours at room temperature under 18W blue LED lamp irradiation (light source about 5cm from the reactor), the reaction was monitored by TLC and/or GC-MS to be complete, after completion of the reaction, the mixture was concentrated in vacuo, diluted with diethyl ether, washed with saturated brine, the combined organic phases were dried over anhydrous sodium sulfate, concentrated in vacuo, and the residue was chromatographed on silica gel (eluent PE/EA=10:1 to 4:1) to give 33.8mg of product 3aa in 71% yield. 1 HNMR(500MHz,Chloroform-d)δ(ppm)8.48(d,J＝6.5Hz,2H),7.85-7.83(m,2H),7.54-7.51(m,1H),7.43-7.40(m,2H),7.27-7.25(m,2H),3.36(s,2H),1.49(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.76,157.89,149.72,137.70,132.99,128.54,127.89,120.85,50.02,37.16,28.69。
Substrate development test preparation series beta-pyridone derivative
Characterization of the product structure:
compound 3ba:33mg,66% yield; r is R f ＝0.2(PE/EA＝4:1)；Yellow oil； 1 H NMR(400MHz,Chloroform-d)δ(ppm)8.42-8.41(m,2H),7.69-7.67(m,2H),7.20-7.18(m,2H),7.13(d,J＝8.0Hz,2H),3.26(s,2H),2.31(s,3H),1.40(s,6H). 13 CNMR(100MHz,Chloroform-d)δ(ppm)197.43,158.07,149.68,143.89,135.12,129.24,128.06,120.90,49.84,37.14,28.76,21.63。
42mg of Compound 3ca, 78% yield; r is R f ＝0.3(PE/EA＝3:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝6.5Hz,2H),7.84-7.81(m,2H),7.27-7.26(m,2H),6.90-6.87(m,2H),3.85(s,3H),3.30(s,2H),1.48(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)196.31,163.45,158.14,149.64,130.79,130.22,120.89,113.67,55.45,49.62,37.23,28.72。
Compound 3da:29mg,57% yield; r is R f ＝0.2(PE/EA＝5:1)；Brown oil； 1 H NMR(400MHz,Chloroform-d)δ(ppm)8.41(d,J＝6.4Hz,2H),7.57-7.53(m,1H),7.43-7.37(m,1H),7.19-7.17(m,2H),7.10-6.98(m,2H),3.34(d,J＝2.4Hz,2H),1.39(s,6H)； 13 C NMR(100MHz,Chloroform-d)δ(ppm)196.34(d,J＝3.8Hz),162.71,160.19,157.86,149.60,134.44(d,J＝8.9Hz),130.36(d,J＝2.6Hz),126.53(d,J＝13.1Hz),124.52(d,J＝3.4Hz),120.89,116.57(d,J＝23.9Hz),55.20(d,J＝7.0Hz),37.2(d,J＝1.4Hz),28.78； 19 F NMR(376MHz,Chloroform-d)δ(ppm)-108.89。
Compound 3ea:26.4mg,43% yieldd; r is R f ＝0.15(PE/EA＝5:1)；Lightbrown oil； 1 HNMR(400MHz,Chloroform-d)δ(ppm)8.43(d,J＝6.4Hz,2H),7.87(d,J＝8.0Hz,2H),7.61(d,J＝8.0Hz,2H),7.20–7.18(m,2H),3.32(s,2H),1.43(s,6H)； 13 C NMR(101MHz,Chloroform-d)δ(ppm)196.76,157.50,149.81,140.11,134.36(d,J＝32.5Hz)128.23,125.69-125.61(m),120.81,50.37,37.14,28.69.； 19 F NMR(376MHz,Chloroform-d)δ(ppm)-63.11。
31mg of compound 3fa, 62% yield; r is R f ＝0.2(PE/EA＝4:1)；Colorless oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.48(d,J＝7.0Hz,2H),7.64-7.63(m,2H),7.35–7.28(m,2H),7.26–7.24(m,2H),3.35(s,2H),2.37(s,3H),1.48(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.98,158.03,149.62,138.34,137.72,133.74,128.44,128.40,125.11,120.89,50.09,37.16,28.70,21.29。
Compound 3ga:37mg,69% yield; r is R f ＝0.15(PE/EA＝3:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝6.0Hz,2H),7.44-7.42(m,1H),7.36–7.29(m,2H),7.27–7.30(m,2H),7.27-7.25(m,2H),3.81(s,3H),3.35(s,2H),1.48(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.55,159.82,158.02,149.61,138.98,129.50,120.88,120.54,119.54,112.17,55.40,50.11,37.15,28.73。
47mg of Compound 3ha, 78% yield; r is R f ＝0.1(PE/EA＝3:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.50(d,J＝6.5Hz,2H),7.49-7.47(m,1H),7.41(d,J＝2.0Hz,1H),7.28–7.26(m,2H),6.83(d,J＝8.5Hz,1H),3.93(s,3H),3.88(s,3H),3.32(s,2H),1.48(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)196.31,158.15,153.34,149.65,149.09,130.92,122.62,120.88,110.12,109.88,56.06,55.94,49.48,37.23,28.76。
45mg of Compound 3ia, 81% yield; r is R f ＝0.1(PE/EA＝4:1)；Colorless oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.44(d,J＝5.0Hz,2H),7.68-7.66(m,2H),7.48–7.45(m,1H),7.34-7.31(m,2H),7.26(d,J＝3.0Hz,2H),3.21(s,2H),2.26-2.20(m,2H),1.89-1.84(m,2H),1.63-1.58(m,2H),1.49-1.34(m,4H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)198.35,155.38,149.58,137.99,132.81,128.37,127.86,122.32,49.76,41.24,35.83,26.03,22.23。
Compound 3ja:18.5mg,41% yield; r is R f ＝0.2(PE/EA＝3:1)；Colorless oil； 1 HNMR(400MHz,Chloroform-d)δ(ppm)8.51(d,J＝6.4Hz,2H),7.93–7.91(m,2H),7.59-7.54(m,1H),7.44-7.44(m,2H),7.21-7.19(m,2H),3.56-3.48(m,1H),3.34-3.18(m,2H),1.35(d,J＝6.8Hz,3H)； 13 C NMR(100MHz,Chloroform-d)δ(ppm)198.08,155.49,149.87,136.87,133.29,128.69,128.01,122.43,45.88,34.75,21.31。
Compound 3ka:25mg,53% yield; r is R f ＝0.2(PE/EA＝5:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.50(d,J＝3.5Hz,2H),7.7.90-7.88(m,2H),7.57-7.53(m,1H),7.46-7.42(m,2H),7.16(d,J＝4.5Hz,2H),3.31-3.24(m,3H),1.84-1.76(m,1H),1.70-1.62(m,1H),0.83(t,J＝7.0Hz,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)198.13,153.77,149.84,136.99,133.16,128.62,127.95,123.16,44.44,42.19,28.70,11.85。
31mg of compound 3la, 45% yield; r is R f ＝0.3(PE/EA＝3:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝5.0Hz,2H),7.89(d,J＝8.0Hz,2H),7.55(t,J＝7.5Hz,1H),7.44(t,J＝7.5Hz,2H),7.17(d,J＝5.0Hz,2H),3.36–3.24(m,3H),1.76-1.59(m,2H),1.30-1.21(m,16H),0.87(t,J＝7.0Hz,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)198.17,154.21,149.82,137.00,133.19,128.65,127.98,123.16,44.87,40.56,35.82,31.89,29.71,29.56,29.48,29.42,29.30,27.33,22.67,14.10。
Compound 3ma 14mg,27% yield; r is R f ＝0.3(PE/EA＝2:1)；Colorless oil； 1 HNMR(500MHz,Chloroform-d)δ(ppm)8.45(d,J＝4.0Hz,2H),7.87(d,J＝8.0Hz,2H),7.55-7.52(m,1H),7.45-7.41(m,2H),7.11(d,J＝4.5Hz,2H),3.37(d,J＝7.0Hz,2H),3.20–3.15(m,1H),1.99-1.92(m,1H),0.99-0.98(m,3H),0.81-0.79(m,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)198.39,152.84,149.51,137.05,133.11,128.61,127.91,123.82,47.11,41.45,32.77,20.61,20.30。
Compounds 3na and 3n 'a: 3na' =1.5:1 (the radio was determinedby 1 H NMR),42mg,71％yield,；R f ＝0.2(PE/EA＝3:1)；White powder,m.p.135-139℃(uncorrected)； 1 H NMR(400MHz,Chloroform-d)δ(ppm)8.50(d,J＝5.2Hz,2H),8.44(d,J＝5.2Hz,1.3H),7.87-7.83(m,3.4H),7.55-7.51(m,1.8H),7.44-7.39(m,3.6H),7.33-7.29(m,2.3H),7.25-7.15(m,7.4H),7.10-7.05(m,2.8H),4.01(t,J＝8.0Hz,1H),3.68(p,J＝7.2Hz,0.72H),3.40-3.28(m,1.4H),3.05-2.99(m,0.8H),2.93(t,J＝7.2Hz,2.8H),2.53-2.47(m,2.5H)； 13 C NMR(101MHz,Chloroform-d)δ(ppm)199.44,197.93,153.46,153.18,149.96,149.76,142.39,138.80,136.82,136.77,133.29,133.17,129.18,128.89,128.67,128.62,128.41,127.98,127.96,127.03,126.49,123.21,123.18,49.81,43.15,42.28,36.41,28.98。
Compounds 3oa and 3o 'a: 3oa' =4:1 (the radio was determined by) 1 H NMR),30mg,48％yield,；R f ＝0.3(PE/EA＝3:1)；colorless oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.53(d,J＝5.0Hz,2H),8.48(d,J＝5.0Hz,0.5H),7.91-7.85(m,2.7H),7.56-7.52(m,1.5H),7.46-7.41(m,2.9H),7.31-7.28(m,0.8H),7.26-7.14(m,5.6H),7.10-7.03(m,2.5H),3.94-3.91(m,0.25H),3.44-3.37(m,1H),3.34-3.26(m,2.1H),3.00-2.97(m,0.84H),2.55-2.44(m,2.4H),2.22-1.93(m,4H),1.76-1.71(m,0.8H)； 13 C NMR(126MHz,Chloroform-d)δ197.84,153.66,149.91,149.78,141.32,136.88,133.22,128.73,128.64,128.59,128.42,128.26,127.94,127.86,126.79,126.00,123.21,50.84,44.89,40.20,38.19,37.24,34.47,33.53,29.68,22.55； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.84,153.66,149.91,149.78,141.32,136.88,133.22,128.73,128.64,128.59,128.42,128.26,127.94,127.86,126.79,126.00,123.21,50.84,44.89,40.20,38.19,37.24,34.47,33.53,29.68,22.55。
Compound 3pa:44mg,76% yield; r is R f ＝0.2(PE/EA＝5:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.48(d,J＝5.5Hz,2H),7.93(d,J＝8.0Hz,2H),7.55(t,J＝7.5Hz,1H),7.44(t,J＝7.5Hz,2H),7.31–7.17(m,7H),4.81(t,J＝7.5Hz,1H),3.79-3.68(m,2H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.16,152.93,149.96,142.51,136.78,133.34,128.84,128.70,128.01,127.88,126.98,123.16,45.30,43.91。
Compound 3qa:45mg,75% yield; r is R f ＝0.1(PE/EA＝5:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.48(d,J＝5.0Hz,2H),7.95-7.93(m,2H),7.58-7.55(m,1H),7.45(t,J＝8.0Hz,2H),7.18(d,J＝6.0Hz,2H),7.15-7.10(m,4H),4.77(t,J＝7.0Hz,1H),3.78-3.67(m,2H),2.30(s,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.26,153.27,149.87,139.49,136.80,136.61,133.32,129.52,128.69,128.02,127.71,123.14,44.93,43.96,20.96。
Compound 3ab 27mg,54% yield; r is R f ＝0.15(PE/EA＝5:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.36(d,J＝5.5Hz,1H),7.85-7.83(m,2H),7.54–7.50(m,1H),7.42-7.39(m,2H),7.07-7.05(m,1H),3.34(s,2H),2.51(s,3H),1.46(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.94,158.20,158.15,148.96,137.75,132.95,128.50,127.90,120.35,117.94,50.03,37.09,28.68,24.56。
Compound 3ac:36mg,57% yield; r is R f ＝0.2(PE/EA＝10:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.57(d,J＝5.0Hz,1H),7.93-7.91(m,2H),7.85-7.83(m,2H),7.68(d,J＝2.0Hz,1H),7.51-7.48(m,1H),7.46-7.42(m,2H),7.40-7.37(m,3H),7.22-7.20(m,1H),3.39(s,2H),1.53(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.94,158.78,157.61,149.50,139.87,137.77,133.00,128.76,128.64,128.54,127.98,127.93,127.12,125.66,119.43,118.11,50.12,37.48,28.76。
Compound 3ad:44mg,64% yield; r is R f ＝0.2(PE/EA＝10:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.52(d,J＝5.0Hz,1H),7.88-7.83(m,4H),7.61(s,1H),7.52-7.48(m,1H),7.40-7.37(m,2H),7.16–7.15(m,1H),6.98-6.95(m,2H),3.84(s,3H),3.38(s,2H),1.53(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)198.02,160.33,158.52,157.28,149.45,137.80,132.97,132.58,128.52,128.31,127.93,118.77,117.26,114.03,55.33,50.09,37.45,28.73。
40mg of Compound 3ae, 58% yield; r is R f ＝0.2(PE/EA＝10:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.55(d,J＝5.0Hz,1H),7.86-7.83(m,4H),7.63(s,1H),7.53-7.50(m,1H),7.42–7.40(m,4H),7.23-7.22(m,1H),3.40(s,2H),1.54(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.87,158.87,156.41,149.66,138.37,137.71,134.89,133.07,128.81,128.75,128.58,128.38,127.92,119.71,117.85,50.11,37.47,28.84。
28mg of compound 3af, 43% yield; r is R f ＝0.2(PE/EA＝10:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.45(d,J＝5.0Hz,1H),7.86-7.85(m,2H),7.63(s,1H),7.55-7.50(m,2H),7.42-7.39(m,2H),7.37–7.36(m,1H),7.14-7.08(m,2H),3.39(s,2H),1.52(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.83,158.68,152.58,149.46,145.22,137.74,133.00,128.55,127.91,127.83,127.27,124.31,119.32,116.10,50.02,37.35,28.66。
22mg of compound 3ag, 32% yield; r is R f ＝0.1(PE/EA＝4:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝5.0Hz,1H),7.87-7.85(m,2H),7.61-7.58(m,2H),7.55-7.52(m,2H),7.44-7.41(m,2H),7.37-7.34(m,3H),7.23-7.21(m,1H),3.38(s,2H),1.50(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.52,158.38,149.92,143.36,137.61,133.06,132.03,128.81,128.57,128.33,127.90,124.46,122.46,120.19,89.15,88.63,49.99,37.15,28.61。
Compound 3ah:32mg,65% yield; r is R f ＝0.2(PE/EA＝10:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.33(d,J＝5.5Hz,1H),8.24(s,1H),7.86-7.84(m,2H),7.54-7.51(m,1H),7.41(t,J＝8.0Hz,2H),7.22(d,J＝5.0Hz,1H),3.52(s,2H),2.44(s,3H),1.54(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.76,154.92,152.94,147.75,137.48,133.01,130.36,128.58,127.82,121.37,48.92,38.32,29.12,20.25。
Compound 3ai:27mg,50% yield; r is R f ＝0.2(PE/EA＝4:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝6.0Hz,2H),7.85-7.83(m,2H),7.54-7.51(m,1H),7.41(t,J＝7.5Hz,2H),7.26(d,J＝2.0Hz,1H),3.36(s,2H),1.49(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.80,157.98,149.69,137.71,133.03,128.57,127.92,120.90,50.04,37.19,28.72。
Compound 3aj:22mg,42% yield；R f ＝0.2(PE/EA＝3:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝6.0Hz,2H),7.85-7.83(m,2H),7.54-7.51(m,1H),7.41(t,J＝7.5Hz,2H),7.26(d,J＝2.0Hz,1H),3.36(s,2H),1.49(s,6H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)197.80,157.98,149.69,137.71,133.03,128.57,127.92,120.90,50.04,37.19,28.72。
Substrate expansion test two preparation series analogue compound
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Characterization of the product structure:
compound 3ra:35mg,72% yield; r is R f ＝0.1(PE/EA＝3:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.45-8.43(m,2H),7.29-7.20(m,5H),7.19-7.17(m,2H),4.49-4.46(m,1H),2.29(s,1H),2.20-2.15(m,1H),2.03-1.99(m,1H),1.45(s,3H),1.32(s,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)158.44,149.55,149.48,145.70,128.50,127.50,127.47,125.65,121.46,72.16,52.62,37.65,29.35,28.35
29mg of Compound 3sa, 51% yield; r is R f ＝0.2(PE/EA＝4:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.52(d,J＝5.5Hz,2H),7.30-7.22(m,5H),7.19(d,J＝7.5Hz,2H),5.73-5.71(m,1H),2.48-2.44(m,1H),1.99-1.96(m,1H),1.65(s,3H),1.40(s,3H),1.35(s,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)169.81,157.65,149.59,141.39,128.51,127.89,126.11,121.31,72.99,50.01,37.19,29.99,27.18,20.70。
Compound 3ta:dr=1.5:1; 54mg,58% yield; r is R f ＝0.2(PE/EA＝3:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.53(s,2H),7.36-7.29(m,5.51H),7.26-7.19(m,4H),7.18-7.16(m,1.21H),7.13-7.11(d,J＝5.5Hz,1.3H),5.58-5.54(m,1H),3.97-3.85(m,1H),2.79-2.71(m,1.08H),2.51–2.43(m,1.42H),2.08-2.00(m,32.72H),1.95-1.93(m,3.65H),1.70-1.67(m,3.60H),1.61-1.54(m,9.86H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)170.84,170.59,153.07,152.88,149.90,142.10,141.84,140.29,140.00,128.94,128.91,128.54,128.25,128.17,127.89,127.83,127.11,127.09,126.89,126.68,74.10,74.03,48.91,48.87,47.29,47.16,42.43,41.51,41.34,36.73,32.90,28.61。
Compound 3ua:dr = 5:1;26mg,31% yield; r is R f ＝0.1(PE/EA＝4:1)；Brown oil； 1 H NMR(400MHz,Chloroform-d)δ(ppm)8.56-8.54(m,2H),8.46-8.45(m,0.4H),7.25-7.20(m,2.4H),7.16-7.06(m,5H),6.99(d,J＝8.0Hz,2H),6.90(d,J＝8.0Hz,2H),6.83-6.79(m,2H),5.66-5.63(m,1H),5.49-5.46(m,0.2H),3.51-3.45(m,0.2H),3.10-3.05(m,1H),2.91(d,J＝25.7Hz,0.67H),2.47-2.41(m,2.8H),2.35–2.22(m,1.5H),2.02-1.78(m,2.8H),1.43–1.26(m,11.5H),1.14(d,J＝2.8Hz,1.2H),0.91-0.86(m,8.6H)； 13 C NMR(100MHz,Chloroform-d)δ(ppm)173.48,173.20,157.94,157.75,149.70,149.61,141.75,141.36,140.61,140.34,137.39,137.33,129.53,129.26,129.14,128.50,128.22,127.79,127.49,127.45,127.25,127.03,125.93,125.48,121.37,121.19,74.08,73.20,50.39,49.95,45.21,45.05,45.00,44.73,42.88,37.27,37.25,37.17,35.93,30.26,30.20,29.82,29.72,28.88,27.76,27.28,22.43,22.41,22.37,22.35,20.77,18.19,17.70。
Compound 3wa:48.2mg,87% yield; r is R f ＝0.4(PE/EA＝5:1)；Brown oil； 1 HNMR(400MHz,Chloroform-d)δ(ppm)8.54(d,J＝5.6Hz,2H),7.38-7.32(m,8H),7.31–7.27(m,4H),5.39(s,1H),4.58-4.48(m,2H)； 13 C NMR(100MHz,Chloroform-d)δ(ppm)151.17,149.87,140.49,137.80,128.80,128.53,128.28,127.86,127.78,127.42,121.73,81.19,70.68。
Compound 3xa:30mg,43% yield; r is R f ＝0.1(PE/EA＝6:1)；Yellow oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.53(d,J＝5.0Hz,2H),7.48-7.46(m,6H),7.38-7.32(m,8H),7.31-7.28(m,3H),4.16(s,2H)； 13 C NMR(126MHz,Chloroform-d)δ(ppm)154.15,149.56,142.11,138.50,129.00,128.36,128.15,127.76,127.36,127.02,122.79,86.38,66.01。
Compound 3ya:48.2mg,35% yield; r is R f ＝0.2(PE/EA＝4:1)；Brown oil； 1 HNMR(500MHz,Chloroform-d)δ(ppm)8.52(d,J＝6.5Hz,2H),7.32-7.23(m,10H),7.20-7.19(m,2H),4.85(s,1H),3.56(s,2H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)150.10,149.99,139.40,137.34,128.96,128.80,128.54,128.45,127.74,127.25,123.49,52.25,36.57。
Compound 3za:11mg,20% yield; r is R f ＝0.2(PE/EA＝10:1)；Colorless oil； 1 HNMR(500MHz,Chloroform-d)δ8.54(d,J＝6.0Hz,2H),7.37-7.35(m,2H),7.30-7.28(m,2H),7.26-7.22(m,5H),6.99-6.96(m,1H),6.91-6.88(m,2H),4.52-4.46(m,3H)； 13 C NMR(126MHz,Chloroform-d)δ158.38,150.59,149.88,139.91,129.53,128.83,128.38,127.33,123.74,121.26,114.72,70.00,49.99。
47mg of Compound 3wb, 82% yield; r is R f ＝0.2(PE/EA＝6:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.41(d,J＝5.0Hz,1H),7.36-7.27(m,10H),7.16(s,1H),7.09(d,J＝5.5Hz,1H),5.35(s,1H),4.62–4.44(m,2H),2.51(s,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)158.59,151.40,149.23,140.69,137.88,128.74,128.51,128.17,127.82,127.78,127.37,121.14,118.93,81.35,70.70,24.55。
37mg of Compound 3wc, 53% yield; r is R f ＝0.3(PE/EA＝10:1)；Brown oil； 1 HNMR(500MHz,Chloroform-d)δ(ppm)8.64(d,J＝5.0Hz,1H),7.00-7.96(m,2H),7.77(s,1H),7.48-7.44(m,2H),7.42-7.38(m,9H),7.35-7.30(m,2H),7.27-7.25(mz,1H),5.47(s,1H),4.64-4.55(m,2H)； 13 C NMR(126MHz,Chloroform-d)δ(ppm)157.74,151.93,149.76,140.58,139.45,137.84,128.96,128.76,128.69,128.50,128.22,127.82,127.78,127.39,127.04,120.29,118.54,81.46,70.77。
Compound 3wg:38mg,51% yieldd; r is R f ＝0.4(PE/EA＝5:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.56-8.50(m,1H),7.62-7.57(m,3H),7.39-7.31(m,14H),7.27-7.26(m,1H),5.40(s,1H),4.61–4.51(m,2H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)151.65,150.11,143.55,140.20,137.68,132.10,128.97,128.87,128.55,128.40,127.91,127.83,127.46,125.04,122.34,120.86,88.21,88.87,80.99,70.76。
50mg of Compound 3wh, 71% yield; r is R f ＝0.3(PE/EA＝5:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)8.49(d,J＝5.0Hz,1H),8.34(s,1H),7.53(d,J＝5.0Hz,1H),7.36-7.26(m,10H),5.51(s,1H),4.52(q,J＝12.0Hz,2H),2.13(s,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)151.20,148.50,147.91,139.23,137.78,130.85,128.58,128.46,128.12,127.87,127.81,127.80,121.10,78.95,70.79,16.27。
34mg of Compound 3wj, 57% yield; r is R f ＝0.2(PE/EA＝5:1)；Brown oil； 1 H NMR(500MHz,Chloroform-d)δ(ppm)7.39-7.34(m,8H),7.33-7.29(m,2H),6.99(s,2H),5.33(s,1H),4.58-4.50(m,2H),2.50(s,6H)； 13 C NMR(126MHz,Chloroform-d)δ(ppm)157.91,151.63,140.87,137.95,128.69,128.49,128.08,127.79,127.31,118.29,81.46,70.69,24.57。
37mg of Compound 3wk, 62% yield; r is R f ＝0.2(PE/EA＝30:1)；Yellow oil； 1 HNMR(500MHz,Chloroform-d)δ(ppm)7.61(d,J＝8.0Hz,2H),7.52-7.50(m,2H),7.40-7.35(m,8H),7.34-7.31(m,2H),5.49(s,1H),4.61-4.51(m,2H)； 13 CNMR(125MHz,Chloroform-d)δ(ppm)147.74,140.74,137.77,132.23,128.78,128.50,128.19,127.84,127.75,127.53,127.28,118.80,111.23,81.77,70.74。
3wl:33mg,50% yieldd; r is R f ＝0.2(PE/EA＝20:1)；Brown oil； 1 HNMR(500MHz,Chloroform-d)δ(ppm)7.99(d,J＝8.0Hz,2H),7.46(d,J＝8.0Hz,2H),7.37-7.27(m,10H),5.47(s,1H),4.57-4.51(m,2H),3.89(s,3H)； 13 CNMR(125MHz,Chloroform-d)δ(ppm)166.92,147.41,141.41,138.08,129.76,129.32,128.59,128.44,127.84,127.74,127.70,127.23,126.93,82.13,70.67,52.03。
35mg of Compound 3wm, 51% yield; r is R f ＝0.2(PE/EA＝2:1)；Brown oil； 1 HNMR(500MHz,Chloroform-d)δ(ppm)7.91-7.88(m,2H),7.61m 7.60(m,2H),7.39-7.30(m,10H),5.51(s,1H),4.61-4.51(m,2H),3.03(s,3H)； 13 C NMR(125MHz,Chloroform-d)δ(ppm)148.71,140.81,139.51,137.76,128.78,128.51,128.18,127.85,127.77,127.73,127.54,127.26,81.74,70.76,44.52。
The above-described embodiments are merely preferred embodiments of the present invention and are not intended to be exhaustive of the possible implementations of the present invention. Any obvious modifications thereof, without departing from the principles and spirit of the present invention, should be considered to be within the scope of the appended claims.

Claims (10)

1. A method for synthesizing a beta-pyridone derivative, which is characterized by comprising the following steps:
adding a compound shown in a formula 1, a compound shown in a formula 2, a photocatalyst, organic amine, alkali and an organic solvent into a reactor, replacing the atmosphere in the reactor with an inert atmosphere, stirring and reacting at room temperature under the condition of illumination, and purifying after the reaction is completed to obtain a beta-pyridone derivative shown in a formula 3; the reaction formula is as follows:
in the above reaction formula, m, n is an integer of 1, 2,3 or 4;
each R is 1 The same or different, independently of one another, are selected from hydrogen, halogen, CN, C 1-20 Alkyl, halogenated C 1-20 Alkyl, C 1-20 An alkoxy group;
represents a double bond, a single bond or the absence thereof; y is selected from O, S, OR a Or is absent; wherein R is a Is hydrogen, C 1-20 Alkyl, C 1-20 An acyl group;
z is selected from CH 2 O or S;
R 2 ,R 3 independently of one another selected from hydrogen, C 1-20 Alkyl, C 6-20 Aryl, C 6-20 aryl-C 1-20 Alkyl, substituted C 6-20 Aryl, or R 2 ,R 3 Are connected to each other and to the connection R 2 ,R 3 Together form C 3-8 A meta cyclic group; wherein the substituted C 6-20 The substituents of the aryl groups being selected from halogen, C 1-6 Alkyl, C 1-6 An alkoxy group; provided that R 2 ,R 3 Not simultaneously selected from hydrogen;
x is selected from N or CR b The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is b Is electron withdrawing group selected from CN, NO 2 、CF 3 、-COOR c 、-SO 2 R d The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is c ，R d Independently selected from C 1-6 Alkyl, C 6-20 An aryl group;
each R is 4 The same or different, independently of one another, are selected from hydrogen, halogen, CN, C 1-20 Alkyl, halogenated C 1-20 Alkyl, C 1-20 Alkoxy, C 6-20 Aryl, C 2-20 Heteroaryl, substituted C 6-20 Aryl, C 6-20 Aryl ethynyl; wherein the substituted C 6-20 The substituents of the aryl groups being selected from halogen, C 1-6 Alkyl, C 1-6 An alkoxy group;
the photocatalyst is selected from fac-Ir (ppy) 3 Or Ir (ppy) 2 (dtbbpy)PF 6 Any one of them; the organic amine is selected from any one of triethylamine or diisopropylethylamine; the organic base is selected from NaOAc, KOAc, K 2 CO 3 Or Na (or) 2 CO 3 Any one or more of the following; the organic solvent is selected from one or more of DMSO, DMF, NMP and acetonitrile.
2. The synthetic method of claim 1 wherein m, n are integers of 1 or 2;
each R is 1 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, bromine, iodine, CN, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 An alkoxy group;
representing double bonds, single bonds or noPresence; y is selected from O, S, OR a Or is absent; wherein R is a Is hydrogen, C 1-6 Alkyl, C 1-20 An acyl group;
z is selected from CH 2 O or S;
R 2 ,R 3 independently of one another selected from hydrogen, C 1-10 Alkyl, C 6-14 Aryl, C 6-14 aryl-C 1-6 Alkyl, substituted C 6-14 Aryl, or R 2 ,R 3 Are connected to each other and to the connection R 2 ,R 3 Together form C 3-8 A membered carbocyclic group; wherein the substituted C 6-14 The substituents of the aryl groups being selected from fluorine, chlorine, bromine, iodine, C 1-6 Alkyl, C 1-6 An alkoxy group; provided that R 2 ,R 3 Not simultaneously selected from hydrogen;
x is selected from N or CR b The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is b Is electron withdrawing group selected from CN, NO 2 、CF 3 、-COOR c 、-SO 2 R d The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is c ，R d Independently selected from C 1-6 Alkyl, C 6-20 An aryl group;
each R is 4 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, bromine, iodine, CN, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, C 6-14 Aryl, C 2-14 Heteroaryl, substituted C 6-14 Aryl, C 6-14 Aryl ethynyl; wherein the substituted C 6-14 The substituents of the aryl groups being selected from fluorine, chlorine, bromine, iodine, C 1-6 Alkyl, C 1-6 An alkoxy group.
3. The synthetic method of claim 2 wherein m, n are integers of 1 or 2;
each R is 1 The same or different, independently of one another, from hydrogen, fluorine, chlorine, methyl, methoxy, trifluoromethyl;
represents a double bond, a single bond or the absence thereof;y is selected from O, S, OR a Or is absent; wherein R is a Is hydrogen, acetyl,
Z is selected from CH 2 O or S;
R 2 ,R 3 independently of one another, selected from hydrogen, methyl, ethyl, isopropyl, n-propyl, n-decyl, phenyl, benzyl, phenethyl, p-methylphenyl, or R 2 ,R 3 Are connected to each other and to the connection R 2 ,R 3 Together form a cyclohexyl group;
x is selected from N or CR b The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is b Is an electron withdrawing group selected from CN, -COOR c 、-SO2R d The method comprises the steps of carrying out a first treatment on the surface of the Wherein R is c ，R d Independently selected from methyl;
each R is 4 The same or different, independently of one another, are selected from hydrogen, fluorine, chlorine, bromine, iodine, CN, methyl, ethyl, methoxy, phenyl, phenylethynyl, thienyl, p-methoxyphenyl, p-chlorophenyl.
4. A method of synthesis according to any of claims 1-3, wherein the photocatalyst is selected from fac-Ir (ppy) 3 The method comprises the steps of carrying out a first treatment on the surface of the The organic amine is selected from triethylamine; the organic base is selected from NaOAc; the organic solvent is selected from DMSO.
5. The synthesis method according to any one of claims 1 to 3, wherein the molar ratio of the compound represented by formula 1, the compound represented by formula 2, the photocatalyst, the organic amine and the base is 1 (0.8 to 1.2): 0.005 to 0.02): 1 to 3.
6. The synthesis method according to claim 5, wherein the compound represented by formula 1, the compound represented by formula 2, the photocatalyst, the organic amine and the base are fed in a molar ratio of 1:1:0.01:2:2.
7. a synthetic method according to any one of claims 1 to 3 wherein the inert atmosphere is a nitrogen atmosphere or an argon atmosphere.
8. A method of synthesizing according to any one of claims 1-3, wherein the illumination conditions are provided by a 3-30W blue LED lamp.
9. A synthetic method according to any one of claims 1 to 3 wherein the reaction time of the stirred reaction is from 4 to 48 hours.
10. A synthetic method according to any one of claims 1 to 3 wherein the purification process comprises the following operations: the reaction solution was concentrated in vacuo, diluted with diethyl ether, washed with saturated brine, the organic phases were combined and dried over anhydrous sodium sulfate, and the residue was concentrated to give a beta-pyridone derivative represented by formula 3, which was separated by silica gel column chromatography.
CN202311699867.6A 2023-12-12 2023-12-12 Synthesis method of beta-pyridone derivative Pending CN117682986A (en)

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