CN117679635B - Electrode slice operation control method, tumor electric field therapeutic apparatus and storage medium - Google Patents
Electrode slice operation control method, tumor electric field therapeutic apparatus and storage medium Download PDFInfo
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Abstract
The application provides an electrode slice operation control method, a tumor electric field therapeutic apparatus and a storage medium, wherein the electrode slice operation control method comprises the following steps: determining a lesion location of the tumor in the lesion site based on medical test data of the tumor patient; constructing a coordinate system, and determining coordinate partitions of the tumor under the coordinate system according to the focus positions; determining a target zone to which a tumor belongs according to the coordinate zone and a coordinate zone of an effective action zone of an electric field generated by a first electrode slice array and a second electrode slice array which provide alternating electric fields at a disease part in a coordinate system; calculating the running time increment according to the period total running time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating running schemes, and respectively adjusting the first running time of the first electrode chip array in the period total running time and the second running time of the second electrode chip array in the period total running time based on the offset azimuth of the target partition relative to the central area and the running time increment.
Description
Technical Field
The application relates to the field of medical technical equipment, in particular to an electrode slice operation control method, a tumor electric field therapeutic apparatus and a computer readable storage medium.
Background
Currently, the use of electric fields to treat tumors is one of the leading edge techniques developed. The principle of electric field therapy is that a tumor electric field therapeutic apparatus is used for generating low-intensity, medium-high frequency and alternating electric fields to interfere the mitosis process of tumor cells, thereby inducing cancer cell death and achieving the purpose of inhibiting proliferation and diffusion of tumor cells. The treatment method has been widely applied to diseases such as glioblastoma, non-small cell lung cancer, malignant pleural mesothelioma and the like.
The electric field is a vector, and electric fields in different directions cannot be used simultaneously on the same target area, so that the tumor electric field therapeutic apparatus established at the present stage adopts a mode of uniformly and alternately applying electric fields in two directions to enhance the therapeutic effect. However, this approach does not take into account the nature of the lesion locations of the different patients, and is necessarily disadvantageous in terms of adequately exploiting the effects of electric field therapy.
Disclosure of Invention
In order to solve the existing technical problems, the application provides an electrode slice operation control method, a tumor electric field therapeutic instrument and a computer readable storage medium, wherein the electrode slice operation control method can be used for adjusting and switching the electric field application time in different directions according to the focus position pertinence of a patient so as to optimize the electric field therapeutic effect.
In order to achieve the above object, the technical solution of the embodiment of the present application is as follows:
in a first aspect, there is provided an electrode sheet operation control method, including:
Determining a lesion location of the tumor in the lesion site based on medical test data of the tumor patient;
constructing a coordinate system by taking a central area of the disease part as a reference, and determining a coordinate partition of the tumor under the coordinate system according to the focus position;
determining a target zone to which the tumor belongs according to the coordinate zone and a coordinate zone of an effective action zone of an electric field generated by the first electrode slice array and the second electrode slice array which provide alternating electric fields at the disease part in the coordinate system;
calculating an operation time increment according to the period total operation time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating operation schemes, and respectively adjusting the first operation time of the first electrode slice array in the period total operation time and the second operation time of the second electrode slice array in the period total operation time based on the offset azimuth of the target partition relative to the central area and the operation time increment.
In a second aspect, there is provided a tumor electric field therapeutic apparatus comprising an electric field generator and a plurality of sets of electric field patches connected to the electric field generator, the electric field generator being configured to output a periodic control signal to the electric field patches to control the electric field patches to operate to generate an alternating electric field based on the received control signal, the electric field generator comprising a processor, a memory connected to the processor, and a computer program stored on the memory and executable by the processor;
the computer program when executed by the processor implements the electrode pad operation control method according to any of the embodiments of the present application.
In a third aspect, an embodiment of the present application provides a computer readable storage medium, where a computer program is stored, where the computer program, when executed by the processor, implements the electrode pad operation control method according to any embodiment of the present application.
According to the electrode slice operation control method provided by the embodiment, the focus position of a tumor in a disease position is determined based on medical detection data of a tumor patient, a coordinate system is built by taking the central area of the disease position as a reference, the operation time of a directional electric field relatively closer to the tumor position in each alternating period is prolonged by calculating the increment of the operation time, so that the total effective acting time of the directional electric field on the area can be prolonged in a targeted manner according to the tumor position, the application scheme is optimized in consideration of the characteristics of the focus positions of different patients, the treatment is favorable for fully inhibiting the proliferation effect of the primary electric field, and the proliferation effect of the primary electric field can be effectively shortened.
In the above embodiments, the tumor electric field therapeutic apparatus and the computer readable storage medium belong to the same concept as the corresponding electrode slice operation control method embodiments, so that the same technical effects as the corresponding electrode slice operation control method embodiments are respectively achieved, and are not described herein.
Drawings
FIG. 1 is a schematic diagram of an application scenario of an electrode slice operation control method in an embodiment;
FIG. 2 is a flow chart of a method of controlling operation of an electrode sheet according to an embodiment;
FIG. 3 is a schematic diagram of constructing a coordinate system with reference to a central region of a disease location in an embodiment;
FIG. 4 is a schematic diagram of an electrode sheet application scheme in one embodiment;
FIG. 5 is a flow chart of an alternative example electrode pad operation control method;
FIG. 6 is a schematic illustration of the application of a single set of electrode pad arrays in an alternative example;
fig. 7 is a schematic diagram of an electric field generator according to an embodiment.
Detailed Description
The technical scheme of the application is further elaborated below by referring to the drawings in the specification and the specific embodiments.
The present application will be further described in detail with reference to the accompanying drawings, for the purpose of making the objects, technical solutions and advantages of the present application more apparent, and the described embodiments should not be construed as limiting the present application, and all other embodiments obtained by those skilled in the art without making any inventive effort are within the scope of the present application.
In the following description, reference is made to the expression "some embodiments" which describe a subset of all possible embodiments, it being noted that "some embodiments" may be the same subset or different subsets of all possible embodiments and may be combined with each other without conflict.
In the following description, the terms "first, second, third" and the like are used merely to distinguish between similar objects and do not represent a specific ordering of the objects, it being understood that the "first, second, third" may be interchanged with a specific order or sequence, as permitted, to enable embodiments of the application described herein to be practiced otherwise than as illustrated or described herein.
Referring to fig. 1, a schematic diagram of an alternative application scenario of an electrode slice operation control method according to an embodiment of the present application is shown, wherein a tumor electric field therapeutic apparatus includes an electric field generator 11, a first electrode slice array 12 and a second electrode slice array 13 connected to the electric field generator 11. In use, the first electrode plate array 12 and the second electrode plate array 13 are respectively attached to disease parts of a tumor patient according to a specified attaching scheme, the electric field generator 11 is used as a control center of the tumor electric field therapeutic apparatus, and periodic control signals are output to the first electrode plate array 12 and the second electrode plate array 13 so as to control the first electrode plate array 12 and the second electrode plate array 13 to alternately apply electric fields in two directions to respectively act on focus areas where tumors are located, and the mitosis process of tumor cells is interfered, so that cancer cell death is induced, and the purpose of inhibiting proliferation and diffusion of the tumor cells is achieved. One switching of the electric field is regarded as one alternating period, so that one alternating period of the alternating electric field is the period total operation period of one alternating period. The periodic control signal refers to dividing one alternating period into two parts of alternately outputting control signals to the first electrode plate array 12 and the second electrode plate array 13, continuously outputting the control signals to the first electrode plate array 12 in a first operation duration, and continuously outputting the control signals to the second electrode plate array 13 in a second operation duration. The electric field generator 11 determines the focus position according to the medical detection data of the tumor patient by loading the computer program for implementing the electrode sheet operation control method according to the embodiment of the present application, and purposefully adjusts the first operation duration of the first electrode sheet array 12 and the second operation duration of the second electrode sheet array 13 in each alternating period, so that the total effective duration of the electric field in the direction relatively closer to the tumor position can be increased.
Referring to fig. 2, an embodiment of the present application provides an electrode plate operation control method, which can be applied to an electric field generator in the application scenario shown in fig. 1. The electrode slice operation control method comprises the following steps:
S101, determining the focus position of the tumor in the disease part based on medical detection data of the tumor patient.
The medical detection data of the tumor patient can comprise various detection and diagnosis data formed by the patient in the diagnosis process, such as nuclear magnetic resonance detection, CT detection data and the like. The disease part refers to the limb part, such as the head, of the human body where the tumor grows. Determining the focus position based on the medical detection data of the tumor patient may refer to determining the tumor position by performing image recognition on the medical detection data as input through nuclear magnetic resonance detection, CT detection data and the like by an image recognition algorithm; it may also be referred to as constructing a model corresponding to the disease site based on nuclear magnetic resonance detection, CT detection data, and morphological data of the disease site, providing a doctor to manually identify a tumor in the model to determine the tumor location, and the like.
S103, constructing a coordinate system by taking the central area of the disease part as a reference, and determining a coordinate partition of the tumor under the coordinate system according to the focus position.
The disease portion is a portion of a limb of a human body, and generally has a substantially symmetrical form, and a central region of the disease portion can be understood as a symmetrical center of the disease portion or a region of a predetermined size including the symmetrical center. The coordinate system, including any form of reference system capable of describing the spatial morphology and position of the disease site, is not limited to the Cartesian coordinate system defined by coordinate axes in the conventional sense, and may be constructed in a grid division manner. By constructing a coordinate system corresponding to the disease location, a coordinate partition of the tumor under the coordinate system is determined according to the disease location, i.e. the physical location information of the tumor in the disease location is converted into coordinate location information under the coordinate system.
S105, determining the target partition to which the tumor belongs according to the coordinate partition and the coordinate area of the effective action area of the electric field generated by the first electrode slice array and the second electrode slice array which provide alternating electric fields at the disease part in the coordinate system.
In the using process of the tumor electric field therapeutic apparatus, the first electrode slice array and the second electrode slice array are respectively attached to the appointed position of the disease position, so that an alternating electric field can be generated under the periodical control signals output by the electric field generator. According to the application positions of the first electrode slice array and the second electrode slice array at the disease position, the effective action areas of the electric fields generated by the first electrode slice array and the second electrode slice array at the disease position respectively can be determined; according to the coordinate system of the disease position, further determining the coordinate areas of the respective electric field effective action areas of the first electrode slice array and the second electrode slice array in the coordinate system, namely converting the physical position information of the respective electric field effective action areas of the first electrode slice array and the second electrode slice array in the disease position into the coordinate position information under the coordinate system. In this way, according to the coordinate position information of the tumor under the coordinate system and the coordinate position information of the effective electric field acting areas of the first electrode slice array and the second electrode slice array respectively under the coordinate system, determining the target partition of the tumor under the coverage of the effective electric field acting areas.
And S107, calculating an operation time increment according to the period total operation time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating operation schemes, and respectively adjusting the first operation time of the first electrode chip array in the period total operation time and the second operation time of the second electrode chip array in the period total operation time based on the offset azimuth of the target partition relative to the central area and the operation time increment.
The period total operation duration of the alternating electric field refers to a duration corresponding to one period, and the electric field generator outputs a control signal to control the electric field of the first electrode plate array and the electric field of the second electrode plate array to alternate once in one period. If the alternating electric fields in two directions are uniformly and alternately applied, the first operation duration of the first electrode slice array in the period total operation time is 1 second, and the second operation duration of the second electrode slice array in the period total operation time is 1 second. The offset value of the target partition relative to the central area may refer to any data form representing the distance between the target partition and the central area, if the partition sequence numbers are sequentially increased to represent the distance between different partitions relative to the central area, the offset value refers to the partition sequence number corresponding to the target partition; for another example, the offset value may be a representation value of the distance value after normalization, and the like, which is not limited herein. The number of alternating operation schemes is generally set by considering the application mode provided by the electric field patch provided by the tumor electric field therapeutic apparatus and the application mode of guiding the operation of the patient by a doctor, and is usually a preset value. Considering the characteristics of different focuses of different tumor patients, the effect of fully digging out the electric field treatment effect is difficult to achieve by uniformly and alternately changing the electric field. After determining the corresponding target partition of the tumor in the coverage area of the effective action area of the electric field, calculating the running time increment according to the period total running time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating running schemes, and adjusting the running time of each of the first electrode plate array and the second electrode plate array in one alternating period based on the running time increment so as to correspondingly adjust the continuous action time of the effective action area of the electric field of the first electrode plate array and the second electrode plate array in one alternating period.
According to the electrode slice operation control method provided by the embodiment, the focus position of a tumor in a disease position is determined based on medical detection data of a tumor patient, a coordinate system is built by taking the central area of the disease position as a reference, the operation time of a directional electric field relatively closer to the tumor position in each alternating period is prolonged by calculating the increment of the operation time, so that the total effective acting time of the directional electric field on the area can be prolonged in a targeted manner according to the tumor position, the application scheme is optimized in consideration of the characteristics of the focus positions of different patients, the treatment is favorable for fully inhibiting the proliferation effect of the primary electric field, and the proliferation effect of the primary electric field can be effectively shortened.
In some embodiments, in step S107, the adjusting the first operation duration of the first electrode pad array in the period total operation time and the second operation duration of the second electrode pad array in the period total operation time respectively includes:
Maintaining the sum of the first operation time length and the second operation time length in each alternating period to be equal to the period total operation time length, adjusting one of the first operation time length of the first electrode slice array in the period total operation time and the second operation time length of the second electrode slice array in the period total operation time to increase the operation time increment, wherein the other one of the first operation time length and the second operation time length is reduced by the operation time increment.
In this embodiment, based on the calculated running time increment, the respective running time of the first electrode slice array and the second electrode slice array in one alternating period is adjusted in such a way that the period total running time of the alternating electric field is kept unchanged, and the running time of one electrode slice array in the two electrode slice arrays is increased, and the running time of the other electrode slice array is reduced. Taking the period total operation time of the alternating electric field as T and the operation time increment as DeltaT as an example, the operation time of one electrode slice array is T/2+ DeltaT, and the operation time of the other electrode slice array is T/2-DeltaT. In this way, the total duration of the effective action of the directional electric field on the focal region can be optimized by increasing the duration of the effective action region of the electric field relatively closer to the tumor location within one cycle of the alternating electric field.
In some embodiments, in step S107, the adjusting the first operation duration of the first electrode pad array in the period total operation time and the second operation duration of the second electrode pad array in the period total operation time based on the offset position of the target partition relative to the central area and the operation time increment includes:
If the target subarea deviates from the central area and is relatively close to the effective action area of the electric field of the first electrode slice array, increasing the first operation duration of the first electrode slice array in the period total operation time based on the operation time increment, and correspondingly reducing the second operation duration of the second electrode slice array in the period total operation time;
And if the target subarea deviates from the central area and is relatively close to the effective action area of the electric field of the second electrode slice array, increasing the second operation duration of the second electrode slice array in the period total operation time based on the operation time increment, and correspondingly reducing the first operation duration of the first electrode slice array in the period total operation time.
In this embodiment, the offset orientation of the target area relative to the central area is mainly used to characterize the offset state of the tumor in the effective electric field acting region of the alternating electric field provided by the first electrode slice array and the second electrode slice array. The offset azimuth is mainly divided into two cases of an electric field effective action area of a target partition relatively close to the first electrode plate array and an electric field effective action area of a target partition relatively close to the second electrode plate array, and the operation time length of the relatively close electrode plate array is correspondingly adjusted based on the calculated operation time increment.
In some embodiments, the calculating the running time increment according to the period total running time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating running schemes includes:
calculating the running time increment delta T according to the following formula by using the period total running time of the alternating electric field as T, the offset value of the target partition relative to the central area as X and the number of alternating running schemes as N:
△T =T/2*X/N。
In this embodiment, a calculation manner is provided for calculating the running time increment according to the period total running time of the alternating electric field, the offset value of the target partition relative to the central area, and the number of alternating running schemes. The ratio of the offset value X of the target partition relative to the central area to the number N of the alternating running schemes is used as a proportionality coefficient for adjusting the increasing and decreasing amplitude of the running time, so that the value-added calculation of the running time is correspondingly related to the distance of the tumor position from the central area and the number of the alternating running schemes, the electric field application schemes are conveniently optimized by considering the characteristics of the focus positions of different patients, and the aim of pertinently prolonging the effective total acting time of the directional electric field acting on the focus area according to the tumor positions under various alternating running schemes is fulfilled.
In some embodiments, in step S107, based on the offset position of the target partition relative to the central area and the running time increment, adjusting a first running duration of the first electrode pad array in the period total running time and a second running duration of the second electrode pad array in the period total running time, respectively, further includes:
and if the target partition does not deviate from the central area, maintaining a first operation duration of the first electrode plate array in the period total operation time and a second operation duration of the second electrode plate array in the period total operation time under the original alternating operation schemes.
In this embodiment, the offset azimuth also includes a case where the target division is not offset from the center area. When the tumor is located in the central area of the disease part, the running time increment is 0 correspondingly, and the running time of each of the first electrode slice array and the second electrode slice array is kept unchanged. Taking the total operation duration of the period of the alternating electric field as T as an example, the first operation duration and the second operation duration are respectively T/2.
In some embodiments, the constructing a coordinate system with reference to the central region of the disease location, determining a coordinate partition of the tumor under the coordinate system according to the lesion position, includes:
Taking the central area of the disease part as a reference, dividing the projection area of the disease part on a projection surface into M annular partitions outwards in sequence, and sequentially increasing the partition serial numbers of the annular partitions from the position closest to the central area to M from 1 outwards;
determining the partition serial number X of the annular partition where the tumor is located according to the focus position; wherein X is more than or equal to 1 and less than or equal to M.
In this embodiment, the coordinate system, which is constructed by taking the central area of the disease portion as a reference and characterizes the spatial morphology and the position of the disease portion, is in a form of sequentially dividing the disease portion into M annular partitions outwards by taking the projection area of the disease portion on the projection plane as a range and taking the central area as a circle center, as shown in fig. 3, the width of each annular partition is equal, the partition serial number corresponding to the central area is 0, and the partition serial numbers corresponding to other annular partitions are sequentially increased from 1 to M outwards. In this way, the size of the partition serial number of each annular partition can correspondingly represent the distance between the corresponding annular partition and the central area, and correspondingly, determining the coordinate partition according to the focus position (i.e. the physical position information of the tumor in the disease position) (i.e. determining the coordinate position information of the tumor in the coordinate system corresponding to the disease position) refers to determining the partition serial number X of the annular partition corresponding to the tumor.
In some embodiments, before determining the target area to which the tumor belongs according to the coordinate area of the coordinate system of the effective acting area of the electric field generated by the coordinate area and the first electrode slice array and the second electrode slice array for providing the alternating electric field at the disease part respectively, the method comprises:
Determining an application scheme of a first electrode slice array and a second electrode slice array for providing an alternating electric field on the disease position according to the focus position and at the intersection point position of a straight line passing through the center of the tumor and perpendicular to the projection plane of the maximum projection area of the tumor and the disease position;
The application scheme comprises the steps of determining the application position of the first electrode plate array according to the intersection point position, and determining the application position of the second electrode plate array on the condition that the electric field direction intersected with the first electrode plate array is formed.
The tumor positions, forms, sizes and the like of different tumor patients have the characteristics, in the using process of the tumor electric field therapeutic apparatus, the application schemes of the electrode plates are set in a targeted mode by considering the tumor characteristics of different tumor patients, the application positions of the first electrode plate array and the second electrode plate array on the disease part under different application schemes are different, as shown in (a), (b) and (c) in fig. 4, schematic diagrams of three application schemes taking the disease part as a head are provided, the directions and coverage ranges of alternating electric fields correspondingly provided by different application schemes are also different, and in an alternative example, the application scheme of one electrode plate can be regarded as an alternating operation scheme for the electrode plates with the same structure; in another alternative example, for electrode sheets of the same configuration, a set of control parameters (total operating duration of the alternating cycle, control frequency, etc.) under the application scheme of the same electrode sheet can be regarded as one alternating operating scheme. Since the shape of the tumor is generally not a regular symmetrical geometric shape, the projection areas on the projection surfaces with different angles in the vertical direction are different, and in this embodiment, the projection surface with the largest projection area of the tumor refers to the projection surface with the corresponding rotation angle when the projection area of the tumor on the projection surface is the largest in the process of rotating around the tumor with the projection surface in the vertical direction. The position of the second electrode slice array is determined by taking the position of the intersection point of the straight line passing through the center of the tumor and being perpendicular to the projection surface of the maximum projection area of the tumor and the disease position as the application position of the first electrode slice array and taking the condition of forming an intersecting electric field as the application position of the first electrode slice array, so that the alternating electric field provided by the first electrode slice array and the second electrode slice array can act on tumor cells to the greatest extent, and the treatment effect is improved.
In order to provide a more general understanding of the electrode pad operation control method according to the embodiment of the present application, please refer to fig. 5, in which a disease portion is a head portion, and a tumor electric field therapeutic apparatus is illustrated as an example of a tumor electric field therapeutic apparatus for treating a tumor of the head portion, the electrode pad operation control method includes:
S31, shooting medical image data of a patient, and checking the position of the tumor of the patient.
S32, determining an electrode slice application scheme according to the intracranial position of the tumor, and constructing two electrode slice array groups, namely an AP group and an LR group. As shown in (a), (b) and (c) of fig. 6, three alternative application modes of a group of electrode pads are shown, and this embodiment takes an AP group application mode as an example.
S33, dividing M subareas in an outward equal division mode by taking the center of the brain as the center, and determining a subarea X where the tumor is located according to the position where the tumor is located; x is determined by the distance between the tumor and the center of the brain, 0<X.ltoreq.M.
The operation time of the electrode slice array group is properly adjusted according to the tumor position of a patient, and the method comprises the following steps:
S34, providing N alternating operation schemes; each alternate operating scheme corresponds to an alternate run time value for the AP group and the LR group.
S35, setting the total running time of the alternating period of the alternating electric field of the AP group and the LR group as T, and setting the running time of each of the AP group and the LR group as T/2 when the tumor is positioned at the center of the brain.
S36, when the tumor is in the AP range, setting the running time of the AP group to be T/2+T/2*X/N and the running time of the LR group to be T/2-T/2*X/N; wherein, the N value can be 3-10.
S37, when the tumor is in the LR range, setting the running time of the LR group to be T/2+T/2*X/N and the running time of the AP group to be T/2-T/2*X/N.
According to the operation control method of the tumor electric field therapeutic apparatus on the electrode slice, the operation time length schemes of the AP group and the LR group are correspondingly adjusted according to the tumor characteristics of different tumor patients, doctors can select the optimal scheme of the proper operation time lengths of the AP group and the LR group by combining N alternating operation schemes and the tumor positions of the patients, so that the effective electric field time ratio of the area near the tumor is effectively improved, the therapeutic effect is improved, the electric field therapeutic apparatus is strongly dependent on the effective wearing time length of the patients, and the total time length of the directional electric field which is formed by the AP group and the LR group is more effectively acted on the focus position under the condition that the total time length is not increased (the period total operation time length of each alternating period is unchanged), so that the patient is extremely good news for the patients, the treatment period of the patients can be shortened, and the survival rate of the patients under the treatment scheme is improved.
In another aspect of the present application, referring to fig. 7, an optional hardware structure diagram of a tumor electric field therapeutic apparatus according to an embodiment of the present application includes an electric field generator and a plurality of groups of electric field patches connected to the electric field generator, where the electric field generator is configured to output a periodic control signal to the electric field patches, so as to control the electric field patches to work to generate an alternating electric field based on the received control signal. The electric field generator comprises a processor 111, a memory 112 connected to said processor 111 and a computer program stored on said memory 112 and executable by said processor; the computer program, when executed by the processor 111, implements the electrode pad operation control method provided by the embodiments of the present application, and can achieve the same technical effects, so that repetition is avoided, and no further description is provided herein.
Wherein the electric field patches comprise a first group of electric field patches which are symmetrically applied to two opposite sides of the disease position and a second group of electric field patches which are symmetrically applied to the other two opposite sides of the disease position; each electric field patch comprises a plurality of electrode plates distributed in a preset shape, the first group of electric field patches form the first electrode plate array, and the second group of electric field patches form the second electrode plate array; the electric field generator outputs continuous control signals to the first electrode slice array in the first operation duration in each alternating period; and outputting a continuous control signal to the second electrode slice array in the second operation duration in each alternating period.
The embodiment of the application also provides a computer readable storage medium, on which a computer program is stored, which when executed by a processor, realizes the processes of the electrode pad operation control method embodiment, and can achieve the same technical effects, and in order to avoid repetition, the description is omitted here. Wherein, the computer readable storage medium is Read-only memory (ROM), random Access Memory (RAM), magnetic disk or optical disk, etc.
It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
From the above description of the embodiments, it will be clear to those skilled in the art that the above-described embodiment method may be implemented by means of software plus a necessary general hardware platform, but of course may also be implemented by means of hardware, but in many cases the former is a preferred embodiment. Based on such understanding, the technical solution of the present invention may be embodied essentially or in a part contributing to the prior art in the form of a software product stored in a storage medium (e.g. ROM/RAM, magnetic disk, optical disk) comprising instructions for causing a terminal (which may be a mobile phone, a computer, an infrared imaging device, etc.) to perform the method according to the embodiments of the present invention.
The foregoing is merely illustrative of the present application, and the present application is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (8)
1. A method of controlling operation of an electrode sheet, comprising:
Determining a lesion location of the tumor in the lesion site based on medical test data of the tumor patient;
constructing a coordinate system by taking a central area of the disease part as a reference, and determining a coordinate partition of the tumor under the coordinate system according to the focus position;
determining a target zone to which the tumor belongs according to the coordinate zone and a coordinate zone of an effective action zone of an electric field generated by the first electrode slice array and the second electrode slice array which provide alternating electric fields at the disease part in the coordinate system;
Calculating an operation time increment according to the period total operation time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating operation schemes, and respectively adjusting a first operation time of the first electrode chip array in the period total operation time and a second operation time of the second electrode chip array in the period total operation time based on the offset azimuth of the target partition relative to the central area and the operation time increment;
The calculating the running time increment according to the period total running time of the alternating electric field, the offset value of the target partition relative to the central area and the number of alternating running schemes comprises the following steps:
Calculating the running time increment delta T according to the following formula by using the period total running time of the alternating electric field as T, the offset value of the target partition relative to the central area as X and the number of alternating running schemes as N: Δt=t/2*X/N;
The adjusting the first operation duration of the first electrode slice array in the period total operation time and the second operation duration of the second electrode slice array in the period total operation time respectively includes:
Maintaining the sum of the first operation time length and the second operation time length in each alternating period to be equal to the period total operation time length, adjusting one of the first operation time length of the first electrode slice array in the period total operation time and the second operation time length of the second electrode slice array in the period total operation time to increase the operation time increment, wherein the other one of the first operation time length and the second operation time length is reduced by the operation time increment.
2. The electrode pad operation control method according to claim 1, wherein the adjusting of the first operation duration of the first electrode pad array in the period total operation time and the second operation duration of the second electrode pad array in the period total operation time based on the offset orientation of the target partition with respect to the central area and the operation time increment, respectively, includes:
If the target subarea deviates from the central area and is relatively close to the effective action area of the electric field of the first electrode slice array, increasing the first operation duration of the first electrode slice array in the period total operation time based on the operation time increment, and correspondingly reducing the second operation duration of the second electrode slice array in the period total operation time;
And if the target subarea deviates from the central area and is relatively close to the effective action area of the electric field of the second electrode slice array, increasing the second operation duration of the second electrode slice array in the period total operation time based on the operation time increment, and correspondingly reducing the first operation duration of the first electrode slice array in the period total operation time.
3. The electrode pad operation control method according to claim 1, wherein the adjusting of the first operation duration of the first electrode pad array in the period total operation time and the second operation duration of the second electrode pad array in the period total operation time based on the offset orientation of the target partition with respect to the central area and the operation time increment, respectively, further comprises:
and if the target partition does not deviate from the central area, maintaining a first operation duration of the first electrode plate array in the period total operation time and a second operation duration of the second electrode plate array in the period total operation time under the original alternating operation schemes.
4. The electrode slice operation control method according to claim 1, wherein the constructing a coordinate system with reference to the central region of the disease site, determining a coordinate partition of the tumor under the coordinate system according to the lesion position, comprises:
Taking the central area of the disease part as a reference, dividing the projection area of the disease part on a projection surface into M annular partitions outwards in sequence, and sequentially increasing the partition serial numbers of the annular partitions from the position closest to the central area to M from 1 outwards;
Determining the partition serial number X of the annular partition where the tumor is located according to the focus position; wherein X is more than or equal to 1 and less than or equal to M.
5. The electrode slice operation control method according to claim 1, wherein the determining the target division to which the tumor belongs based on the coordinate division and the coordinate areas in the coordinate system of the electric field effective action areas generated by the first electrode slice array and the second electrode slice array providing the alternating electric field at the disease site, respectively, comprises:
Determining an application scheme of a first electrode slice array and a second electrode slice array for providing an alternating electric field on the disease position according to the focus position and at the intersection point position of a straight line passing through the center of the tumor and perpendicular to the projection plane of the maximum projection area of the tumor and the disease position;
The application scheme comprises the steps of determining the application position of the first electrode plate array according to the intersection point position, and determining the application position of the second electrode plate array on the condition that the electric field direction intersected with the first electrode plate array is formed.
6. The tumor electric field therapeutic apparatus comprises an electric field generator and a plurality of groups of electric field patches connected with the electric field generator, wherein the electric field generator is used for outputting periodic control signals to the electric field patches so as to control the electric field patches to work to generate an alternating electric field based on the received control signals, and the tumor electric field therapeutic apparatus is characterized in that the electric field generator comprises a processor, a memory connected with the processor and a computer program stored on the memory and executable by the processor;
the computer program, when executed by the processor, implements the electrode pad operation control method according to any one of claims 1 to 5.
7. The tumor electric field therapy apparatus according to claim 6, wherein said electric field patches include a first set of electric field patches symmetrically applied to opposite sides of said disorder site, and a second set of electric field patches symmetrically applied to opposite sides of said disorder site; each electric field patch comprises a plurality of electrode plates distributed in a preset shape, the first group of electric field patches form the first electrode plate array, and the second group of electric field patches form the second electrode plate array;
The electric field generator outputs continuous control signals to the first electrode slice array in the first operation duration in each alternating period; and outputting a continuous control signal to the second electrode slice array in the second operation duration in each alternating period.
8. A computer-readable storage medium, characterized in that the computer-readable storage medium has stored thereon a computer program which, when executed by a processor, implements the electrode pad operation control method according to any one of claims 1 to 5.
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