CN117653411A

CN117653411A - Prosthesis system

Info

Publication number: CN117653411A
Application number: CN202211043537.7A
Authority: CN
Inventors: 周冠冠; 李文思; 胡占明; 李芳�
Original assignee: Yingmai Medical Technology Shanghai Co ltd
Current assignee: Yingmai Medical Technology Shanghai Co ltd
Priority date: 2022-08-29
Filing date: 2022-08-29
Publication date: 2024-03-08

Abstract

The embodiment of the application relates to the technical field of medical devices, in particular to a prosthesis system, which comprises a conveying device and a prosthesis; the conveying device comprises a connecting shaft and a first control wire; the prosthesis comprises a base and a first movable piece, wherein the base is detachably coupled with the connecting shaft, and a preset channel is formed at the coupling position; the first control wire has connected in sequence: a first section for independently driving the first movable member to move, and a second section; when the connecting shaft is coupled with the base, the preset channel is in a closed state, and the second section is restrained in the preset channel, so that the first section is restrained at the coupling position; when the connecting shaft and the base are detached, the preset channel is in a non-closed state, and the first control wire is allowed to be separated from the preset channel. The prosthesis system provided by the embodiment of the application can reduce the manufacturing cost of the prosthesis system under the condition that the conveying device can safely and reliably adjust the movable part in the prosthesis.

Description

Prosthesis system

Technical Field

The embodiment of the application relates to the technical field of medical devices, in particular to a prosthesis system.

Background

The traditional operation (such as open chest operation) has the defects of large wound (namely, the incision length is generally more than or equal to 10 cm, the scar is long after the incision is healed, the appearance is affected), large pain (namely, the incision part after the operation is often accompanied with pain), slow recovery (the injury of muscles, blood vessels and corresponding nerves near the incision is easy to be caused due to the large operation incision, and the complication of certain tissue infection possibly occurs, so that the recovery speed of a patient is slow) and the like, so the minimally invasive operation is applied. The minimally invasive surgery has the advantages of small incision (namely, the incision is generally between 0.5 cm and 1 cm), small pain (the pain caused by the incision is small for patients), quick recovery (the damage to the viscera and the interference to the functions of the viscera are greatly reduced, complications are not easy to occur, and the postoperative recovery time is shortened).

The existing minimally invasive surgery mostly adopts a conveying device to convey the prosthesis to a target position in a human body (namely a position in the human body where the surgery needs to be implemented) through a natural cavity channel of the human body and other surgical paths, then a control wire of the conveying device is operated to adjust a movable part in the prosthesis so that the state of the prosthesis changes, and then the implantation of the prosthesis is completed. US20210145574A1 discloses an embodiment in which the state of a movable member of a prosthesis is changed by adjusting the movable member with a control wire. In US20210145574A1, one end of the control wire has a bump, the other end passes through a hole in the movable member and extends to the proximal end of the conveying device, so that an operator can adjust the position and/or posture of the movable member by controlling the wire, a through hole is formed in the connecting shaft of the conveying device, the hole diameter of one end of the through hole is smaller than the bump, the hole diameter of the other end of the through hole is larger than the bump, and therefore, the position of the bump is limited by the end of the through hole smaller than the bump, and when the control wire needs to be evacuated, the bump is evacuated from the other end of the through hole larger than the bump.

However, such a connection shaft is relatively complex in structure, which results in a relatively difficult processing of the connection shaft, which results in a relatively high manufacturing cost of the delivery device and thus of the prosthesis system with such a delivery device. Accordingly, there is a need to provide a prosthesis system that reduces the manufacturing costs of the prosthesis system in the case where the delivery device of the prosthesis system is capable of safely and reliably adjusting the movable parts of the prosthesis.

Disclosure of Invention

It is an object of embodiments of the present application to provide a prosthesis system that reduces the manufacturing costs of the prosthesis system in case the delivery device is able to safely and reliably adjust the moving parts in the prosthesis.

To solve the above problems, embodiments of the present application provide a prosthesis system comprising a delivery device and a prosthesis; the conveying device comprises a connecting shaft and a first control wire; the prosthesis comprises a base and a first movable piece, wherein the base is detachably coupled with the connecting shaft, and a preset channel is formed at the coupling position; the first control wire has connected in sequence: a first section for independently driving the first movable member to move, and a second section; when the connecting shaft is coupled with the base, the preset channel is in a closed state, and the second section is restrained in the preset channel, so that the first section is restrained at the coupling position; when the connecting shaft is separated from the base, the preset channel is in a non-closed state, and the first control wire is allowed to be separated from the preset channel.

Further, embodiments of the present application provide yet another prosthesis system comprising a delivery device and a prosthesis; the conveying device comprises a connecting shaft, a central rod and a first control wire; the prosthesis comprises a base and a first movable piece, wherein the base is coupled with the connecting shaft when the central rod is positioned at the coupling position of the connecting shaft and the base; the first control wire has connected in sequence: a first section for independently driving the first movable member to move, and a second section; when the central rod is positioned at the coupling position of the connecting shaft and the base, a preset channel in a closed state is formed at the coupling position of the central rod and the connecting shaft and/or the base, and the second section is restrained in the preset channel, so that the first section is restrained at the coupling position; when the central rod is positioned outside the coupling position of the connecting shaft and the base, the preset channel is in a non-closed state, and the first control wire is allowed to be separated from the preset channel.

In the prosthesis system provided by the embodiment of the application, when a prosthesis implantation operation is implemented, the preset channel is in a closed state so as to restrict the second section of the first control wire inside the preset channel, so that the distal end of the first control wire is restricted at the coupling position, and then after the prosthesis is conveyed to a target position in a human body through an operation path such as a natural cavity of the human body by the connecting shaft, the first movable part of the prosthesis can be adjusted by operating the first section of the first control wire, so that the state of the prosthesis is changed, and the prosthesis implantation is realized; when the conveying device and the prosthesis are required to be separated, the base of the prosthesis is detached from the connecting shaft of the conveying device, so that the preset channel is in a non-closed state, and in the non-closed state, the first control wire is allowed to be separated from the preset channel, so that the first control wire is separated from the prosthesis, the first control wire is extracted from the human body, and then the connecting shaft is withdrawn from the human body, so that implantation operation is completed. Therefore, the conveying device of the prosthesis system can safely and reliably adjust the movable part in the prosthesis, change the state of the prosthesis, realize implantation of the prosthesis and ensure that the prosthesis system is operated more safely and reliably.

Meanwhile, as the preset channel in the prosthesis system provided by the embodiment of the application has a closed state and a non-closed state, the related operation is completed by matching with the first control wire. Manufacturing the pre-set channel is not as difficult as manufacturing a through hole having different sizes at both ends in the prior art, thus allowing for lower manufacturing costs of the prosthesis system.

Drawings

FIG. 1 is a schematic illustration of a distal end of a delivery device coupled to a mitral valve clip according to some embodiments of the present application;

FIG. 2 is a schematic view of a structure of a mitral valve clip according to some embodiments of the present application with a clamping arm coupled to a delivery device;

FIG. 3 is a schematic longitudinal view of a connecting shaft and a base according to some embodiments of the present application to form a predetermined channel;

FIG. 4 is an exploded view of a connection shaft and a base provided in some embodiments of the present application;

FIG. 5 is an exploded view of yet another coupling shaft and base provided in some embodiments of the present application;

FIG. 6 is an exploded view of yet another coupling shaft and base provided in some embodiments of the present application;

FIG. 7 is a longitudinal cross-sectional view of a connecting shaft and a base according to some embodiments of the present application mated to form a predetermined channel;

FIG. 8 is a longitudinal cross-sectional view of yet another coupling shaft according to some embodiments of the present application mated with a base to form a predetermined channel;

FIG. 9 is a schematic structural view of a control wire according to some embodiments of the present application;

FIG. 10 is an enlarged view of a portion a of FIG. 9;

FIG. 11 is a schematic illustration of a construction of yet another control wire provided in some embodiments of the present application;

FIG. 12 is an enlarged view of a portion b of FIG. 11;

FIG. 13 is a schematic view of a configuration of a clamping arm in cooperation with a control wire according to some embodiments of the present application;

FIG. 14 is a schematic view of yet another embodiment of a clamping arm in combination with a control wire;

FIG. 15 is a schematic view of a still further embodiment of a clamping arm in combination with a control wire;

FIG. 16 is a longitudinal schematic view of a center rod and a connecting shaft or base cooperating to form a predetermined channel according to some embodiments of the present application;

FIG. 17 is an exploded view of a center rod, a connecting shaft, and a base provided in some embodiments of the present application;

FIG. 18 is a schematic longitudinal view of a center rod and a connecting shaft and/or a base that cooperate to form a predetermined channel according to some embodiments of the present application;

fig. 19 is an exploded view of yet another center rod, connecting shaft and base provided in some embodiments of the present application.

Detailed Description

Those of ordinary skill in the art will understand that in various embodiments of the present application, numerous technical details are set forth in order to provide a better understanding of the present application. However, the technical means claimed in the present application can be realized based on various changes and modifications of the following embodiments.

In various embodiments of the present application, "proximal" refers to the end that is closer to the operator, farther from the patient; accordingly, "distal" refers to the end that is closer to the patient, farther from the operator. In the embodiments of the present application, "parallel", "perpendicular" should not be construed narrowly as 0 ° or 90 °, but rather as including a reasonable angular range from 0 ° or 90 ° with some float, provided that the technical effect is achieved.

Some embodiments of the present application provide a prosthetic system comprising a delivery device and a prosthesis; the conveying device comprises a connecting shaft and a first control wire; the prosthesis comprises a base and a first movable piece, wherein the base is detachably coupled with the connecting shaft, and a preset channel is formed at the coupling position; the first control wire has connected in sequence: a first section for independently driving the first movable member to move, and a second section; when the connecting shaft is coupled with the base, the preset channel is in a closed state, and the second section is restrained in the preset channel, so that the first section is restrained at the coupling position; when the connecting shaft is separated from the base, the preset channel is in a non-closed state, and the first control wire is allowed to be separated from the preset channel.

In the prosthesis system provided by some embodiments of the present application, when performing a prosthesis implantation operation, the preset channel is in a closed state to restrict the second section of the first control wire inside the preset channel, so that the distal end of the first control wire is restricted at the coupling position, and then after the connecting shaft conveys the prosthesis to a target position in a human body through an operation path such as a natural cavity of the human body, the first movable part of the prosthesis can be adjusted by operating the first section of the first control wire, so that the state of the prosthesis is changed, and the prosthesis implantation is realized; when the conveying device and the prosthesis are required to be separated, the base of the prosthesis is detached from the connecting shaft of the conveying device, so that the preset channel is in a non-closed state, and in the non-closed state, the first control wire is allowed to be separated from the preset channel, so that the first control wire is separated from the prosthesis, the first control wire is extracted from the human body, and then the connecting shaft is withdrawn from the human body, so that implantation operation is completed. Therefore, the conveying device of the prosthesis system can safely and reliably adjust the movable part in the prosthesis, change the state of the prosthesis, realize implantation of the prosthesis and ensure that the prosthesis system is operated more safely and reliably.

For the purpose of making the objects, technical solutions and advantages of the present application more apparent, embodiments of the present application will be described in detail below with reference to the accompanying drawings.

Referring to fig. 1-15, some embodiments of the present application provide a prosthetic system comprising a delivery device 100 and a prosthesis; the delivery device 100 includes a connecting shaft 110 and a first control wire 120; the prosthesis comprises a base 210 and a first movable member, wherein the base 210 is detachably coupled with the connection shaft 110, and a preset channel 300 is formed at the coupling; the first control wire 120 has, connected in sequence: a first section 121 for independently driving the movement of the first movable member, and a second section 122; wherein, when the connecting shaft 110 and the base 210 are coupled, the preset channel 300 is in a closed state, and the second section 122 is constrained in the preset channel 300, so that the first section 121 is constrained at the coupling position; when the connection shaft 110 and the base 210 are separated, the preset tunnel 300 is in a non-closed state, and the first control wire 120 is allowed to be separated from the preset tunnel 300.

Thus, when a prosthesis is to be implanted, the prosthesis may be delivered into the body by coupling the connecting shaft 110 with the base 210 and forming the predetermined channel 300 that restricts the second section 122 from assuming a closed state. When the prosthesis is in the target position in the human body, the first movable member of the prosthesis is adjusted by manipulating the proximal end of the first segment 121, so that the state of the prosthesis is changed, thereby achieving implantation of the prosthesis. When the delivery device 100 and the prosthesis are required to be separated, the preset channel 300 is in a non-closed state by separating the connecting shaft 110 from the base 210, so that the first control wire 120 can be directly separated from the limitation of the preset channel 300, and the first control wire 120 can be drawn out from the human body.

Because the conveying device 100 is separated from the prosthesis, when the first control wire 120 is pulled out from the human body, the preset channel 300 is in a non-closed state, so that the first control wire 120 is directly separated from the constraint of the preset channel 300, the first control wire 120 is not required to be blocked on the connecting shaft 110, and the probability of accidents during operation can be reduced.

It should be noted that the closed state of the preset channel 300 means that the preset channel 300 is closed in its circumferential shape; the non-closed state of the preset channel 300 means that the shape of the preset channel 300 in the circumferential direction thereof is divided into a plurality of non-closed portions.

In some embodiments, when the first segment 121 is constrained to the coupling, the first segment 121 is adjacent to the predetermined channel 300 disposed at the coupling or partially within the predetermined channel 300 disposed at the coupling. That is, when the first section 121 is constrained to the coupling, the first section 121 is adjacent to the predetermined channel 300, or when the first section 121 is constrained to the coupling, at least a portion of the connection between the first section 121 and the second section 122 is located within the predetermined channel 300.

In some embodiments, the predetermined channel 300 is disposed at the coupling of the connection shaft 110 and the base 210 at an angle to the axis of the connection shaft 110. Specifically, an included angle between the extending direction of the preset channel 300 and the axis of the connecting shaft 110 is greater than 0 ° and less than 180 °, and the preset channel 300 is disposed at the coupling position of the connecting shaft 110 and the base 210. Preferably, the extending direction of the preset channel 300 is perpendicular to the axis of the connecting shaft 110.

In some embodiments, a portion of the wall surface of the preset channel 300 is formed on the connection shaft 110, and another portion is formed on the base 210; when the connection shaft 110 is coupled with the base 210, the portion of the connection shaft 110 for forming the preset channel 300 and the portion of the base 210 for forming the preset channel 300 are disposed opposite to each other and together form the preset channel 300 in a closed state; when the connection shaft 110 and the base 210 are disassembled, the portion of the connection shaft 110 for forming the preset passage 300 and the portion of the base 210 for forming the preset passage 300 are separated from each other, so that the shape of the preset passage 300 in the circumferential direction thereof is divided into two portions which are not closed.

In some embodiments, the connecting shaft 110 has a first contact surface 111; the base 210 has a second contact surface 211 for contacting at least a portion of the first contact surface 111 when the connection shaft 110 and the base 210 are coupled; the predetermined channel 300 is located between the first contact surface 111 and the second contact surface 211.

Thus, when the connecting shaft 110 and the base 210 are coupled, the first contact surface 111 contacts at least part of the second contact surface 211, so that the predetermined channel 300 between the first contact surface 111 and the second contact surface 211 is in a closed state; when the connection shaft 110 is separated from the base 210, the first contact surface 111 is separated from the second contact surface 211, so that the predetermined channel 300 between the first contact surface 111 and the second contact surface 211 is in a non-closed state.

Further, a first through groove 112 is formed on the surface of the first contact surface 111 or the surface of the second contact surface 211; when the base 210 is coupled to the connecting shaft 110, the wall surface of the first through groove 112 and the corresponding portion of the other contact surface together form a preset channel 300 in a closed state; when the base 210 is separated from the connecting shaft 110, the wall surface of the first through groove 112 is separated from the other contact surface, so that the preset channel 300 is in a non-closed state.

Specifically, as shown in fig. 4, the first through groove 112 is disposed on the first contact surface 111, and the first through groove 112 includes a first wall surface and a first notch. The cross-sections of the first wall surfaces are preferably all arc-shaped, more preferably arc-shaped. When the connecting shaft 110 is coupled to the base 210, the first notch is attached to the corresponding portion of the second contact surface 211, the first wall surface is connected to the corresponding portion of the second contact surface 211, and the first through groove 112 and the corresponding portion of the second contact surface 211 form a preset channel 300 in a closed state; when the connecting shaft 110 is separated from the base 210, the corresponding portions of the first notch and the second contact surface 211 are not attached, and the corresponding portions of the first wall surface and the second contact surface 211 are separated from each other, so that the preset channel 300 is in a non-closed state.

Alternatively, the surface of the first contact surface 111 is provided with a second through groove 113, and the surface of the second contact surface 211 is provided with a third through groove 212; when the base 210 is coupled to the connecting shaft 110, the wall surface of the second through slot 113 and the wall surface of the third through slot 212 together form a preset channel 300 in a closed state; when the base 210 is separated from the connection shaft 110, the wall surface of the second through slot 113 is separated from the wall surface of the third through slot 212, so that the preset channel 300 is in a non-closed state.

Specifically, as shown in fig. 5, the second through groove 113 includes a second wall surface and a second notch. The third through slot 212 includes a third wall and a third slot. The cross-sections of the second wall surface and the third wall surface are preferably arc-shaped, more preferably arc-shaped. When the connecting shaft 110 is coupled with the base 210, the second wall surface is connected with the third wall surface, the second notch is attached to the third notch, and the second through slot 113 and the third through slot 212 form a preset channel 300 in a closed state; when the connecting shaft 110 is separated from the base 210, the second wall surface and the third wall surface are separated from each other, and the first notch and the second notch are separated from each other and are no longer attached to each other, so that the preset channel 300 is in a non-closed state.

It should be noted that, the side wall of any through groove is provided with an opening, and the opening is connected with the notch of the through groove and is used for accommodating part of the first control wire; after the preset channel 300 is formed, the openings of the side walls of the through grooves form the end openings of the preset channel 300.

It should be further noted that, in the present embodiment, when the above-mentioned arbitrary contact surfaces contact to form the preset channel 300 in the closed state, at least the contact surfaces near the through groove forming the preset channel 300 are attached to each other, so as to prevent the first control wire 120 from sliding away from the preset channel 300; meanwhile, the two through grooves or the corresponding parts of the through grooves and the other contact surface cannot be attached, otherwise, the preset channel 300 in a closed state cannot be formed.

In some embodiments, the first contact surface 111 and the second contact surface 211 are configured to: the contact portion of the second contact surface 211 with the first contact surface 111 is such that when the connection shaft 110 moves away from the base 210 in the axial direction of the connection shaft 110, the connection shaft 110 is restrained from moving in the radial direction of the connection shaft 110 with respect to the base 210. In this way, the constraint connection shaft 110 can be moved relative to the base 210 along the axial direction thereof, and the constraint connection shaft 110 can be moved relative to the base 210 along the radial direction thereof, so that the coupling between the connection shaft 110 and the base 210 is facilitated.

Specifically, as shown in fig. 4 and 5, the first contact surface 111 includes a distal first distal blocking surface 1111, a proximal first proximal blocking surface 1113, and a first inclined surface 1112 between the first distal blocking surface 1111 and the first proximal blocking surface 1113; second contact surface 211 includes a second distal stop surface 2111 distal for engaging first distal stop surface 1111, a second proximal stop surface 2113 proximal for engaging first proximal stop surface 1113, and a second angled surface 2112 between second distal stop surface 2111 and second proximal stop surface 2113 for engaging first angled surface 1112; the maximum vertical distance (H in fig. 4) of the first inclined surface 1112 from the edge of the connection shaft 110 becomes smaller as the distance from the distal end of the base 210 becomes larger.

By providing the first inclined surface 1112, the contact portion of the second contact surface 211 with the first contact surface 111 can be realized such that the connection shaft 110 moves in the radial direction of the connection shaft 110 with respect to the base 210 at the same time when the connection shaft 110 moves away from the base 210 in the axial direction of the connection shaft 110.

Further, the first inclined surface 1112 is an inclined surface, a curved surface or a wavy surface. Preferably, the first inclined surface 1112 is an inclined surface or curved surface. In this way, the manufacture of the first bevel 1112 may be facilitated.

More specifically, the first through groove 112 is disposed on the first inclined surface 1112 or the second inclined surface 2112.

For example: in one illustrative example, as shown in fig. 4, the first through slot 112 is disposed on the first angled surface 1112 and the second contact surface 211 may preferably further include a transition surface 2114 between the second angled surface 2112 and the second proximal stop surface 2113. More preferably, transition surface 2114 is parallel to the axis of connecting shaft 110. First channel 112 is disposed on first ramp 1112 adjacent first proximal stop surface 1113 and corresponds to transition surface 2114. When the connecting shaft 110 is coupled with the base 210, the first distal blocking surface 1111 and the second distal blocking surface 2111 are engaged, the first inclined surface 1112 and the second inclined surface 2112 are engaged, the first proximal blocking surface 1113 and the second proximal blocking surface 2113 are engaged, and the first through slot 112 and the transition surface 2114 form the predetermined channel 300 in the closed state. The first through slot 112 includes a first wall and a first slot. When the connecting shaft 110 is coupled with the base 210, the first notch is fitted with the transition surface 2114, and the first wall surface of the first through groove 112 and the transition surface 2114 form the side wall of the preset channel 300 in the closed state. After the connecting shaft 110 is separated from the base 210, the first inclined surface 1112 and the second inclined surface 2112 are separated, so that the first notch of the first through groove 112 is no longer attached to the transition surface 2114, and the first wall surface of the first through groove 112 forming the sidewall of the preset channel 300 is separated from the transition surface 2114. Thus, the preset tunnel 300 is non-closed. Of course, the first through groove 112 may be disposed at other positions on the first contact surface 111 or the second contact surface 211.

Alternatively, the first through groove is provided in the second ramp 2112, and the first contact surface 111 may preferably comprise a transition surface between the first ramp 1112 and the first proximal stop surface 1113, the second contact surface 211 no longer being provided with a transition surface 2114. Similarly, when the connecting shaft 110 is coupled to the base 210, the transition surface of the first through groove and the first contact surface 111 forms a preset channel 300 in a closed state; when the connecting shaft 110 is separated from the base 210, the first through groove is separated from the transition surface of the first contact surface 111, and the preset channel 300 is not closed.

In another exemplary example, as shown in fig. 5, the second through-slot 113 is disposed on a surface of the first contact surface 111 and the third through-slot 212 is disposed on a surface of the second contact surface 211 proximate to the first proximal stop surface 1113 and proximate to the second proximal stop surface 2113. When the connection shaft 110 is coupled with the base 210, the first distal blocking surface 1111 and the second distal blocking surface 2111 are engaged, the first inclined surface 1112 and the second inclined surface 2112 are engaged, the first proximal blocking surface 1113 and the second proximal blocking surface 2113 are engaged, and the second through slot 113 and the third through slot 212 form the preset channel 300 in a closed state. When the connection shaft 110 is separated from the base 210, the first inclined surface 1112 and the second inclined surface 2112 are separated, so that the second through groove 113 is separated from the third through groove 212. Thus, the preset tunnel 300 is non-closed.

Further, the conveying apparatus 100 further includes: the central rod 130, the central rod 130 is configured such that when the central rod 130 is positioned at the coupling of the connection shaft 110 and the base 210, the connection shaft 110 and the base 210 remain at least radially relatively stationary to achieve the coupling of the connection shaft 110 and the base 210. Thus, in combination with the above-described "contact portion of the second contact surface 211 with the first contact surface 111 such that the connection shaft 110 is constrained to move radially relative to the base 210 with respect to the connection shaft 110 when the connection shaft 110 moves axially away from the base 210 along the connection shaft 110", the coupling between the connection shaft 110 and the base 210 can be achieved by keeping at least the connection shaft 110 and the base 210 radially relatively stationary by using the center rod 130.

In one example, the connection shaft 110 and the base 210 are provided with receiving channels axially arranged along the connection shaft 110; when the central rod 130 is placed in the receiving channel and is placed at the coupling position of the connecting shaft 110 and the base 210, the connecting shaft 110 and the base 210 can be kept at least relatively radially stationary.

Specifically, the receiving channel includes a first receiving channel provided on the connection shaft 110 and axially arranged along the connection shaft 110; the receiving channels further include a second receiving channel disposed at the base 210 coaxially with the first receiving channel; the central rod 130 passes through the first receiving channel and extends to the coupling of the connecting shaft 110 and the base 210 such that the connecting shaft 110 and the base 210 remain at least radially relatively stationary. When the connecting shaft 110 is coupled with the base 210, the first receiving channel and the second receiving channel are communicated with each other and together form the receiving channel.

In another example, the central rod 130 is a hollow rod, and when the central rod 130 is sleeved at the coupling position of the connecting shaft 110 and the base 210, the connecting shaft 110 and the base 210 can be at least kept relatively stationary in the radial direction. Further, the central rod 130 is further provided with a receiving channel extending axially from the distal end to the proximal end of the central rod 130, the receiving channel being arranged in correspondence of the preset channel 300 in the circumferential direction of the connecting shaft 110 for receiving a portion of the first segment 121 located outside the preset channel 300. In this manner, interference between the central rod 130 and the first segment 121 is avoided as the central rod 130 moves, and in particular, the central rod 130 is retracted proximally, such that the position of the first control wire 120 changes, which in turn affects the attitude and/or position of the first moveable member.

While in other embodiments, the coupling of the connection shaft 110 and the base 210 may achieve axial relative rest between the connection shaft 110 and the base 210, other components may be required to achieve radial relative rest between the connection shaft 110 and the base 210. In yet another exemplary example, one of the first contact surface 111 and the second contact surface 211 has a second protrusion 1114, the other has a second groove 2115, and both the protruding direction of the second protrusion 1114 and the recessed direction of the second groove 2115 are radial directions of the connecting shaft 110; the second protrusion 1114 is embedded in the second groove 2115 when at least a portion of the first contact surface 111 contacts the second contact surface 211. Thus, when the second protrusion 1114 is engaged in the second groove 2115, if the connection shaft 110 is required to move axially along the connection shaft 110 relative to the base 210, the second protrusion 1114 is required to move away from the second groove 2115, and when the second protrusion 1114 is moved away from the second groove 2115, the connection shaft 110 is required to move radially along the connection shaft 110 relative to the base 210 because the protruding direction of the second protrusion 1114 and the recessed direction of the second groove 2115 are both radial directions of the connection shaft 110. In this way, it is possible to realize that when the connection shaft 110 moves away from the base 210 in the axial direction of the connection shaft 110, the connection shaft 110 needs to move in the radial direction of the connection shaft 110 with respect to the base 210, so that the coupling between the connection shaft 110 and the base 210 is facilitated. In this embodiment, similar to the above embodiment, two through grooves forming the preset channel 300 may be provided on the first contact surface 111 and the second contact surface 211, respectively; the number of through grooves constituting the predetermined path 300 may be one, and may be disposed on the first contact surface 111 or the second contact surface 211. The through groove can be formed on the second protrusion 1114, or on the groove wall or groove bottom of the second groove 2115, although the through groove can be formed at other positions of the first contact surface 111 and/or the second contact surface 211.

In one example, as shown in fig. 6, the number of sixth through grooves 118 is one, and the sixth through grooves 118 are provided at the bottom of the second grooves 2115.

Further, in this example, the first contact surface 111 may include a distal third distal blocking surface 1115, a proximal-to-distal first connection surface 1116, and a proximal third proximal blocking surface 1117; second contact surface 211 may include a fourth distal stop surface 2116 distal to and for engaging third distal stop surface 1115, a second attachment surface 2117 proximal to and for engaging first attachment surface 1116, and a fourth proximal stop surface 2118 proximal to and for engaging third proximal stop surface 1117. At this time, one of the second protrusion 1114 and the second groove 2115 described above may be provided on the first connection surface 1116, and the other may be provided on the second connection surface 2117. Further, at this point the first connection face 1116 and the second connection face 2117 may be parallel to the axis of the connection shaft 110.

At this time, the conveying apparatus 100 may also be provided with a central rod 130, and the central rod 130 may be configured such that when the central rod 130 is located at the coupling position of the connecting shaft 110 and the base 210, the connecting shaft 110 and the base 210 remain at least radially relatively stationary, so as to achieve the coupling of the connecting shaft 110 and the base 210. For example, the connection shaft 110 and the base 210 may be provided with receiving channels axially arranged along the connection shaft 110; the second projection 1114 has a sufficient extension to partially overlap the receiving channel with the sixth through slot 118; when the central rod 130 is placed in the accommodating channel and is placed at the coupling position of the connecting shaft 110 and the base 210, the connecting shaft 110 and the base 210 can be kept at least radially relatively static, so that the connecting shaft 110 and the base 210 are fixedly connected, and at least part of the wall surface of the sixth through groove 118 and the wall surface of the central rod 130 form a preset channel in a closed state together.

In other embodiments, the connection shaft 110 has a first coupling portion 114, the base 210 has a second coupling portion 213, and the first coupling portion 114 or the second coupling portion 213 is disposed offset in the axial direction of the connection shaft 110; when the offset coupling portions are driven to be axially arranged along the connecting shaft 110, the first coupling portion 114 and the second coupling portion 213 are coupled, the first contact surface 111 is located on a side of the first coupling portion 114 facing the second coupling portion 213, and the second contact surface 211 is located on a side of the second coupling portion 213 facing the first coupling portion 114. In this embodiment, as shown in the above embodiment, there may be two through grooves forming the preset channel 300, which are respectively disposed on the first contact surface 111 and the second contact surface 211; the number of through grooves constituting the predetermined path 300 may be one, and may be disposed on the first contact surface 111 or the second contact surface 211.

Further, one of the first coupling part 114 and the second coupling part 213 has a first protrusion 115, and the other has a first groove 214; wherein the first protrusion 115 is separated from the first groove 214 when the first coupling part 114 or the second coupling part 213 is biased in the axial direction of the connection shaft 110; when the biased coupling portion is urged to be axially disposed along the connecting shaft 110, the first protrusion 115 is received in the first recess 214.

Specifically, in one example, referring to fig. 7, the first coupling part 114 further includes an inwardly biased support 116, and the first protrusion 115 is located at a distal end of the support 116 and extends perpendicular to an axial direction of the support 116; the base 210 is provided with a second accommodating channel 215 for accommodating the first coupling part 114, and the first groove 214 is arranged on the wall surface of the second accommodating channel 215; when the support 116 is urged to deflect so that the axis of the support 116 is parallel to the axis of the connecting shaft 110, the first protrusion 115 is received in the first recess 214. At this time, the first contact surface 111 may be a surface of the support 116 facing the wall surface of the second receiving channel 215, and the second contact surface 211 may be a portion of the wall surface of the second receiving channel 215 of the base 210 facing the support 116. As in the above embodiments, the surface of the first contact surface 111 or the surface of the second contact surface 211 is provided with the first through groove 112; or, the surface of the first contact surface 111 is provided with a second through groove 113, and the surface of the second contact surface 211 is provided with a third through groove 212, which is not described herein.

In yet another example, referring to fig. 8, the first coupling part 114 further has a support 117 biased outwardly, and the first protrusion 115 is located at a distal end of the support 117 and protrudes inwardly perpendicular to an axial direction of the support 117; the first groove 214 is disposed on an outer wall surface of the base 210; when the support 117 is urged to deflect such that the axis of the support 117 is parallel to the axis of the connecting shaft 110, the first protrusion 115 is received in the first recess 214. At this time, the first contact surface 111 may be a surface of the support 117 facing the outer wall surface of the base 210, and the second contact surface 211 may be a portion of the outer wall surface of the base 210 facing the support 117. In the above embodiment, the surface of the first contact surface 111 or the surface of the second contact surface 211 is provided with the first through groove 112; or, the surface of the first contact surface 111 is provided with a second through groove 113, and the surface of the second contact surface 211 is provided with a third through groove 212, which is not described herein.

Further, the conveying apparatus 100 further includes: the central rod 130, the central rod 130 being configured such that when the central rod 130 is located at the coupling of the connection shaft 110 with the base 210, the central rod 130 drives the coupling portion of the offset arrangement to be axially arranged along the connection shaft 110.

Referring to fig. 7, the connection shaft 110 and the base 210 are also provided with receiving channels axially arranged along the connection shaft 110; when the center rod 130 is placed in the receiving channel and is placed at the coupling of the connecting shaft 110 and the base 210, the coupling portion of the offset arrangement is driven to be axially arranged along the connecting shaft 110. Specifically, in this example, the first coupling portion 114 includes the supporting member 116 biased inward, and after the central rod 130 is placed in the receiving channel, the central rod 130 moves distally and passes through the first coupling portion 114 and the second coupling portion 213 to abut against the supporting member 116, so that the supporting member 116 is driven to deflect outward, and when the axis of the supporting member 116 is parallel to the axis of the connecting shaft 110, the first protrusion 115 is received in the first groove 214, so that the connecting shaft 110 is fixed to the base 210 (i.e. the connecting shaft 110 is coupled to the base 210). Meanwhile, the first through groove 112 provided on the surface of the first contact surface 111 or the surface of the second contact surface 211 forms a preset channel in a closed state with the other contact surface; or, the second through groove 113 provided on the surface of the first contact surface 111 and the third through groove 212 provided on the surface of the second contact surface 211 form a preset passage in a closed state.

Referring to fig. 8, the central rod 130 is a hollow rod; when the central rod 130 is sleeved at the coupling position of the connecting shaft 110 and the base 210, the coupling part arranged in a biased manner can be driven to be axially arranged along the connecting shaft 110. Specifically, the first coupling portion 114 includes the above-mentioned supporting member 117 biased outwards, when the central rod 130 is sleeved at the coupling position of the connecting shaft 110 and the base 210, the central rod 130 is sleeved on the first coupling portion 114 and the second coupling portion 213 to abut against the supporting member 117, so that the supporting member 117 is driven to deflect inwards, and when the axis of the supporting member 117 is parallel to the axis of the connecting shaft 110, the first protrusion 115 can be accommodated in the first groove 214, so as to fix the connecting shaft 110 and the base 210. Meanwhile, the first through groove 112 provided on the surface of the first contact surface 111 or the surface of the second contact surface 211 forms a preset channel in a closed state with the other contact surface; or, the second through groove 113 provided on the surface of the first contact surface 111 and the third through groove 212 provided on the surface of the second contact surface 211 form a preset passage in a closed state. Preferably, the central rod 130 may also be provided with a receiving channel extending axially from the distal end to the proximal end of the central rod 130, which is disposed corresponding to the preset channel 300 in the circumferential direction of the connecting shaft 110, which is constructed and functions the same as those of the other examples described above, and will not be repeated herein.

For convenience of description, a portion of the preset channel 300 on a side of the second section 122 near the first section 121 is defined as a first portion, a portion of the preset channel 300 on a side of the second section 122 far from the first section 121 is defined as a second portion, and a portion of the preset channel 300 between the first portion and the second portion is defined as a channel middle portion.

In some embodiments, the diameter of the second section 122 is greater than the diameter of the first section 121. In this manner, it may be convenient to implement that the second section 122 is constrained within the preset channel 300 in the closed state when the preset channel 300 is in the closed state, such that the distal end of the first section 121 is constrained at the coupling. More specifically, the diameter of the second section 122 is smaller than the diameter of the middle portion of the channel, and the diameter of the second section 122 is larger than the diameter of the first portion, so that the second section 122 cannot be separated from the predetermined channel 300 from the direction from the middle portion of the channel toward the first portion, and the second section 122 is constrained inside the predetermined channel 300. Preferably, the diameter of the second section 122 is larger than the diameter of the second portion, so that the second section 122 cannot be separated from the predetermined channel 300 from the direction from the middle of the channel to the second portion, and further ensures that the second section 122 is constrained inside the predetermined channel 300 and cannot be moved out.

In some embodiments, the first control wire 120 further includes a third segment 123 connected to an end of the second segment 122 remote from the first segment 121. Preferably, the diameter of the second section 122 is greater than the diameter of either the first section 121 or the third section 123, or the diameter of the second section 122 is less than the diameter of the junction of either the first section 121 or the third section 123 with the second section 122. In this way, it is convenient to implement that the second section 122 is constrained within the preset channel 300 in the closed state when the preset channel 300 is in the closed state, so that the distal ends of the first section 121 and the third section 123 are constrained at the coupling point.

More specifically, the radial dimension of at least the portion of any one of the first and third sections 121 and 123 connected to the second section 122 is greater than the radial dimension of the second section 122, the minimum radial dimension of the preset passage 300 in the closed state is greater than or equal to the radial dimension of the second section 122, and the maximum radial dimension of the preset passage 300 in the closed state is less than the radial dimension of the portion of any one of the first and third sections 121 and 123 connected to the second section 122. Thus, when the preset channel 300 is in the closed state, at least the connection portion of any one of the first segment 121 and the third segment 123 and the second segment 122 cannot be placed into the preset channel 300, and the second segment 122 can be constrained in the preset channel 300.

Alternatively, the radial dimensions of the first segment 121 and the third segment 123 are smaller than the radial dimension of the second segment 122, the maximum radial dimension of the preset channel 300 in the closed state is greater than or equal to the radial dimension of the second segment 122, the minimum radial dimension of the preset channel 300 in the closed state is less than or equal to the radial dimension of the second segment 122, and the maximum radial dimension and the minimum radial dimension of the preset channel 300 in the closed state are not equal. For example, the diameter of the second section 122 is smaller than the diameter of the middle of the channel, and the diameter of the second section 122 is larger than the diameter of either of the first portion and the second portion. In this way, the second section 122 can be constrained in the preset channel 300 in the closed state and cannot be moved out of the preset channel 300, so that any one of the first section 121 and the third section 123 is constrained at the coupling position, and the first section 121 can control the movement of the first movable member.

In some embodiments, the prosthesis further comprises a second moveable member; the third section 123 is used for independently driving the second movable member to move; when the connecting shaft 110 and the base 210 are coupled, the preset channel 300 is in a closed state, and the second section 122 is constrained in the preset channel 300 in the closed state, so that the first section 121 and the third section 123 are both constrained at the coupling position. Thus, one control wire (i.e., the first control wire 120 in this embodiment) can be used to control the movement of two moving members (i.e., the first moving member and the second moving member).

In particular, referring to fig. 11 and 12, the difference compared to the above-described embodiments is that the third section 123 is also used to control the second movable member, and the third section 123 extends to the proximal end of the delivery device 100, so as to facilitate manipulation of the third section 123 at the proximal end of the delivery device 100, thereby controlling the second movable member. The specific structure and dimensions of the third section 123 are not described in detail.

See fig. 9 and 10. In some embodiments, the prosthesis also includes a second moveable member; the delivery device 100 also includes a second control wire 140; the second control wire 140 has connected in sequence: a third section 123 for independently driving the movement of the second movable member, and a fourth section 141; wherein, when the preset channel 300 is in the closed state, the fourth segment 141 is also constrained in the preset channel 300, so that the third segment 123 is constrained at the coupling position; when the preset tunnel 300 is in the non-closed state, the second control wire 140 is allowed to be separated from the preset tunnel 300. Thus, the first control wire 120 can be used to control the movement of the first movable member, and the second control wire 140 can be used to control the movement of the second movable member.

Specifically, the second portion is located on a side of the fourth segment 141 adjacent to the third segment 123. The radial dimension of the second section 122 is greater than the radial dimension of the first section 121 and greater than the radial dimension of the first portion of the preset channel 300 in the closed condition; the radial dimension of the fourth segment 141 is greater than the radial dimension of the third segment 123 and greater than the radial dimension of the second portion of the preset tunnel 300 in the closed condition. In this way, when the second section 122 and the fourth section 141 are constrained in the predetermined channel 300 in the closed state, it is ensured that the second section 122 does not move out of the first portion, and the fourth section 141 does not move out of the second portion, so that the first control wire 120 is used to control the movement of the first movable member, and the second control wire 140 is used to control the movement of the second movable member. Meanwhile, the dimension of the channel middle portion of the preset channel 300 in the closed state is greater than the radial dimension of the second section 122 and greater than the radial dimension of the fourth section 141, thereby ensuring that the second section 122 and the fourth section 141 can be accommodated in the preset channel 300 in the closed state. Preferably, the second section 122 has a diameter greater than the diameter of the second portion and the fourth section 141 has a diameter greater than the diameter of the first portion. In this way, the second segment 122 does not exit the second portion and the fourth segment 141 does not exit the first portion, further ensuring that the second segment 122 and the fourth segment 141 are constrained within the predetermined path 300 in the closed state.

With continued reference to fig. 1-3, and with simultaneous reference to fig. 13-15. In some embodiments, the prosthesis comprises one movable member, i.e., a first movable member. By controlling the movement of the first movable element by means of the first segment 121, a change of state of the prosthesis can be achieved, where a "state" can be a change of structure, shape of the whole or part of the prosthesis, e.g. from a compressed state to a deployed state, and e.g. from an unlocked state to an unlocked state between the prosthesis and the target tissue, between the prosthesis and the delivery system, between the internal components of the prosthesis; the "state" may also be a change in position and/or posture of the prosthesis in whole or in part (e.g. the first movable member). For example, a stent graft used to treat aortic stenosis typically uses a constraining wire (i.e., a first movable member) to constrain the stent graft in a compressed state during delivery, and after the stent graft is positioned to a target site, the constraining wire is released by a control wire to effect the transition of the stent graft from the compressed state to the expanded state.

In other embodiments, the prosthesis comprises two moving parts, a first moving part and a second moving part, the first moving part being controlled to move by the first section 121 and the second moving part being controlled to move by the third section 123, to effect a change in the state of the prosthesis. When it is desired to separate the delivery device 100 from the prosthesis, the pre-set channel 300 may be left in an unoccluded state, thereby allowing the first control wire 120 (or the first control wire 120 and the second control wire 140) to be detached from the pre-set channel 300, so as to facilitate withdrawing the first control wire 120 (or the first control wire 120 and the second control wire 140) from the human body and separating the first control wire 120 (or the first control wire 120 and the second control wire 140) from the prosthesis.

The specific type of prosthesis is not limited in this embodiment. In some embodiments, the prosthesis is a mitral valve clip 200 for treating mitral regurgitation. In other embodiments, the prosthesis is a tricuspid valve clip for treating tricuspid valve regurgitation. In another embodiment, the prosthesis is a stent graft for treating aortic stenosis. The mitral valve clip 200 will be described further below. It should be emphasized that the prosthesis herein is a mitral valve clip 200, which is merely illustrative and not limiting of the present application.

The mitral valve clip 200 includes a base 210 and a clamping arm (i.e., a moveable member) that is rotatable relative to an axis of the base 210. Further, the mitral valve clip 200 also includes a clamping seat that is also rotatable relative to the axis of the base 210. The clamping arms are located at the proximal end of the base 210 and the clamping seats are located at the distal end of the base 210, and clamping of the mitral valve native leaflet edges is achieved by rotation of the clamping arms and the clamping seats. Further, the clamping arms include a first clamping arm 220 (i.e., a first movable member) and a second clamping arm 230 (i.e., a second movable member). Preferably, the first and second clamping arms 220, 230 are symmetrically arranged about the axis of the base 210.

It should be emphasized that the first movable member is the first clamping arm 220 and the second movable member is the second clamping arm 230 are also only illustrated in the case that the prosthesis is the mitral valve clip 200, and in other embodiments, the first movable member may not be the first clamping arm 220 and the second movable member may not be the second clamping arm 230, and the specific types of the first movable member and the second movable member are not limited in this application.

Likewise, the clamping mount comprises a first clamping mount 240 and a second clamping mount 250, which are symmetrically arranged about the axis of the base 210 and lie in a plane in which the first clamping arm 220 and the second clamping arm 230 lie, to better clamp the edges of the anterior and posterior mitral valve leaflets. Here, "the plane in which the first and second clamping arms 220 and 230 are located" refers to a plane formed by the axis of the first clamping arm 220 and the axis of the second clamping arm 230; the phrase "the first clamping seat 240 and the second clamping seat 250 are located on the plane where the first clamping arm 220 and the second clamping arm 230 are located" means that the axes of the first clamping seat 240 and the second clamping seat 250 are located on the plane where the first clamping arm 220 and the second clamping arm 230 are located. After the mitral valve clip 200 is delivered to the mitral valve target site, treatment of mitral regurgitation is achieved by driving rotation of the clamping arms and the clamping seats to clamp the anterior and posterior leaflets of the mitral valve between the clamping arms and the clamping seats.

In one example, the first clamping arm 220 and the second clamping arm 230 are resiliently coupled by a transition 225. Further, a transition 225 is provided at the distal end of the base 210. Preferably, the first clamping arm 220 and the second clamping arm 230 are both sheet-shaped. Preferably, the first clamping arm 220, the transition 225, and the second clamping arm 230 are integrally formed to form an inverted-like omega shape. And the first clamping arm 220 and the second clamping arm 230 are in an extended state in a natural state. As shown in fig. 2, when the first section 121 is lifted, the first clamping arm 220 is driven to rotate to approach upward and toward the base 210, and the first clamping arm 220 is elastically deformed. And when the first segment 121 is pushed, the first clamping arm 220 rotates away from the base 210 to a desired position. Accordingly, when the third section 123 is pulled, the second clamping arm 230 is driven to rotate to move upward and toward the base 210, and the second clamping arm 230 is elastically deformed. And when the third segment 123 is pushed, the second clamping arm 230 rotates away from the base 210 to the desired position.

The first clamping seat 240 and the second clamping seat 250 are rotatably connected with the base 210. Preferably, the first clamping seat 240 and the second clamping seat 250 are rotatably connected to the base 210 through the same rotation shaft. Preferably, the cross-sectional shape of the first clamping seat 240 perpendicular to the axial direction is U-shaped to better wrap around the mitral valve first leaflet edge 401 and the first clamping arm 220. Also, the cross-sectional shape of the second clamping seat 250 perpendicular to the axial direction is U-shaped to better wrap around the mitral valve second leaflet edge 402 and the second clamping arm 230. When the mitral valve clamp 200 clamps the mitral valve leaflet, the first clamping seat 240 and the second clamping seat 250 are driven to rotate and squeeze the edge of the mitral valve leaflet and the first clamping arm 220 and the second clamping arm 230, so as to clamp the mitral valve leaflet by the mitral valve clamp 200.

The manner in which the first segment 121 controls the movement of the first movable member and even the third segment 123 controls the movement of the second movable member is not particularly limited in this embodiment. For the mitral valve clip 200, the first segment 121 need only be movably coupled to the first clamping arm 220. Thus, in one aspect, the first clamping arm 220 may rotate with the movement of the first segment 121; in another aspect, when the delivery device 200 needs to be separated from the mitral valve clip 200, the first control wire 120 may be separated from the first clamping arm 220. The same is true of the relationship of the third segment 123 and the second clamping arm 230, and will not be described again.

Referring to fig. 9, 11 and 13-15, the first segment 121 extends distally from the pre-set channel 300 and proximally back toward the delivery device 200 after extending to the location of the first clamping arm 220. In this way, the first section 121 forms a curved portion at the position of the first clamping arm 220, and the curved portion is interpenetrating with the first clamping arm 220 or the accessory provided on the first clamping arm 220, so as to control the rotation of the first clamping arm 220.

Meanwhile, the second section 122 is configured to be detachable from the first clamping arm 220. Thus, when the first control wire 120 is to be pulled away from the first clamping arm 220, it is ensured that the second segment 122 is pulled away from the first clamping arm 220.

In addition, when the third segment 123 is part of the first control wire 120, the third segment 123 is also configured to be detachable from the first clamping arm 220. Thus, when the first control wire 120 is to be pulled away from the first clamping arm 220, it is ensured that the third segment 123 is pulled away from the first clamping arm 220.

When the third section 123 is a part of the second control wire 140, the structure between the third section 123 and the second clamping arm 230 is the same as the structure between the first section 121 of the first control wire 120 and the first clamping arm 220, and will not be described herein. And the construction between the fourth section 141 and the second clamping arm 230 is the same as the construction between the second section 122 of the first control wire 120 and the first clamping arm 220 described above, and will not be described again.

Preferably, when the third section 123 is a part of the first control wire 120, the junction of the third section 123 and the second section 122 is a first transition portion, and the area of the cross section of the first transition portion in the direction of the second section 122 toward the third section 123 gradually increases. In this manner, there may be no significant bulge at the junction of the second section 122 and the third section 123. In this way, in the process of retracting the first control wire 120 to enable the whole first control wire 120 to be pulled away from the first clamping arm 220, the second section 122 and the third section 123 can be pulled away from the first clamping arm 220 more smoothly in sequence, so as to avoid affecting the posture and/or the position of the first clamping arm 220. In addition, by providing the first transition portion that is a smooth transition, when withdrawing the first control wire 120, the first control wire 120 can be prevented from being stuck on other parts of the prosthesis system, and meanwhile, the first control wire 120 can be prevented from being worn, so that the possibility of fracture of the first control wire 120 is reduced.

Similarly, when the third section 123 is a part of the first control wire 120, the connection between the first section 121 and the second section 122 may be a second transition portion having the same function as the first transition portion, which is not described herein again.

Referring to fig. 13, the first clamping arm 220 is provided with an attachment, which is a fixing wire 223, the fixing wire 223 is provided to the first clamping arm 220, and the fixing wire 223 forms a body 226 for interpenetrating with the above-mentioned curved portion.

Specifically, the body 226 is annular to form a first through hole for interpenetrating with the above-mentioned curved portion, and the fixing wire 223 further has a transition portion 102 connected with the body 226, and the transition portion 102 is disposed on the first clamping arm 220. Wherein the curved portion of the first segment 121 passes through the first through hole to interpenetrate the body 226.

Further, the first clamping arm 220 is provided with a second through hole 224 on a surface thereof, the body 226 passes through the second through hole 224 from a side of the first clamping arm 220 away from the base 210, the transition portion 102 is disposed on a side of the first clamping arm 220 away from the base 210, and the transition portion 102 is configured to be unable to pass through the second through hole 224.

Alternatively, the transition portion 102 of the fixing wire 223 is wound around the second through hole 224 to be fixedly connected with the first clamping arm 220.

Referring to fig. 14, the first clamping arm 220 is provided with two third through holes 221, and an end of the first section 121 remote from the second section 122 (i.e., an end of the curved portion) passes through one third through hole 221 from a side of the first clamping arm 220 remote from the first clamping seat 240, and then passes through the other third through hole 221 from a side of the first clamping arm 220 close to the first clamping seat 240. Thus, the curved portion of the first section 121 is made to interpenetrate the first clamping arm 220.

Alternatively, the first clamping arm 220 is provided with more than two even number of third through holes 221, and the end of the first section 121 remote from the second section 122 (i.e. the end of the curved portion) passes alternately through these third through holes 221. In this way, the curved portion of the first section 121 may also be interpenetrating the first clamping arm 220.

Referring to fig. 15, the first clamping arm 220 is provided with a third protrusion 101, the third protrusion 101 of the first clamping arm 220 is provided with a fourth through hole 227, and an end of the first section 121 remote from the second section 122 (i.e., an end of the bent portion) passes through the fourth through hole 227. In this way, the curved portion of the first section 121 may also be interpenetrating the first clamping arm 220. Preferably, the extending direction of the fourth through hole 227 is the same as the extending direction of the first clamping arm 220.

It should be noted that, the connection between the third section 123 and the second clamping arm 230 may refer to the connection between the first section 121 and the first clamping arm 220, and will not be described herein.

In addition, when the third segment 123 is part of the first control wire 120 and the third segment 123 controls the rotation of the second clamping arm 230, the first segment 121 and the second segment 122 may also each be configured to be detachable from the second clamping arm 230. Thus, when the first control wire 120 is to be pulled away from the second clamping arm 230, it is ensured that the first segment 121 and the second segment 122 are pulled away from the second clamping arm 230.

Further, the mitral valve clip 200 further comprises: and an actuating assembly for controlling the rotation of the first and second clamping bases 240 and 250.

Referring to fig. 1 and 2, the actuating assembly includes a first link 261, a second link 262, and a slider 263. Wherein, the proximal end of the first connecting rod 261 is rotatably connected with the first clamping seat 240, the distal end is rotatably connected with the sliding block 263, and the sliding block 263 can axially move relative to the base 210. Thus, the first link 261, the first clamping seat 240, the base 210 and the slide 263 form a movement mechanism similar to a crank slide mechanism. When the slider 263 is driven toward or away from the base 210, the first clamping seat 240 is driven to perform a rotational movement. Likewise, a second link 262 is rotatably coupled at a proximal end to the second clamp mount 250 and at a distal end to the slide 263. Likewise, the second link 262, the second clamping seat 250, the base 210 and the slide 263 also form a movement mechanism similar to a crank slide mechanism. When the slider 263 is driven toward or away from the base 210, the second clamping seat 250 is driven to perform a rotational movement.

Further, the slider 263 has a "T" shape, i.e., the slider 263 includes a horizontal portion and a vertical portion. Both ends of the horizontal portion of the slider 263 are rotatably connected to the first link 261 and the second link 262, respectively, and the vertical portion of the slider 263 is detachably connected, e.g., screw-connected, to the center rod 130. In this way, the slide 263 can be driven to move by the central rod 130, so that the first clamping seat 240 and the second clamping seat 250 rotate. Preferably, the first and second links 261 and 262 are symmetrically arranged about the axis of the base 210. Thus, when the slider 263 drives the first clamping seat 240 and the second clamping seat 250 to move, the rotation angle of the first clamping seat 240 is the same as the rotation angle of the second clamping seat 250.

Preferably, the conveying apparatus 100 further includes: the guide pipe 150 is sleeved on the connecting shaft 110, and the guide pipe 150 is provided with two second channels extending along the axial direction of the guide pipe 150; the end of the first segment 121 remote from the second segment 122 extends from and through one second channel distal end to the second channel proximal end, and the end of the third segment 123 remote from the second segment 122 (or the fourth segment 141) extends from and through the other second channel distal end to the second channel proximal end. In this manner, an operator may be facilitated to lift the end of the first section 121 distal from the second section 122 at the proximal end of the catheter 150 to adjust the angle of rotation of the first clamping arm 220, and to lift the end of the third section 123 distal from the second section 122 (or the fourth section 141) at the proximal end of the catheter 150 to adjust the angle of rotation of the second clamping arm 230. When the first control wire 120 is required to be separated from the mitral valve clip 200, the preset channel is adjusted to a non-closed state, and an operator pulls the end of the first segment 121 away from the second segment 122 or pulls the end of the third segment 123 away from the second segment 122 (or the fourth segment 141) at the proximal end of the catheter 150 to separate the first control wire 120 from the mitral valve clip 200.

See fig. 16-19. Some embodiments of the present application provide yet another prosthetic system comprising a delivery device and a prosthesis; the delivery device includes a connecting shaft 410, a central rod 420, and a first control wire; the prosthesis comprises a base 510 and a first movable member, wherein the base 510 is coupled to the connecting shaft 410 when the central rod 420 is positioned at the coupling of the connecting shaft 410 to the base 510; the first control wire has connected in sequence: a first section for independently driving the first movable member to move, and a second section; wherein, when the central rod 420 is located at the coupling position of the connecting shaft 410 and the base 510, the central rod 420 and the connecting shaft 410 and/or the base 510 form a preset channel 600 in a closed state at the coupling position, and the second section is restrained in the preset channel 600, so that the first section is restrained at the coupling position; when the center pole 420 is located outside the coupling of the connection shaft 410 and the base 510, the preset channel 600 is in a non-closed state, and the first control wire is allowed to be separated from the preset channel 600.

In this embodiment, the wall of the predetermined channel 600 in the closed state is formed of two parts, one of which is provided for the center rod 420 and the other of which is provided for the connecting shaft 410 and/or the base 510.

It should be noted that the prosthesis system provided in this embodiment is substantially the same as that provided in the above embodiment, except that: the preset channel 600 in the closed state in this embodiment is located between the central rod and the connecting shaft 410 and/or the base 510. In addition, the other matters described in the above embodiment can be applied to this embodiment without any conflict with the embodiment, for example: the embodiment of the coupling between the connection shaft 410 and the base 510 by the center rod 420 in this embodiment does not conflict with the embodiment of the coupling between the connection shaft 110 and the base 210 by the center rod 130 described in the above embodiment, and therefore the embodiment of the coupling between the connection shaft 110 and the base 210 by the center rod 130 described in the above embodiment can be applied to this embodiment.

In some embodiments, the connecting shaft 410 and the base 510 are provided with receiving channels axially disposed along the connecting shaft 410; at this time, when the central rod 420 is placed in the receiving channel and is disposed at the coupling position of the connecting shaft 410 and the base 510, the connecting shaft 410 and the base 510 are at least kept radially relatively stationary, so as to achieve coupling between the connecting shaft 410 and the base 510. In other embodiments, the connecting shaft 410 and the base 510 are provided with receiving channels axially disposed along the connecting shaft 410, and the connecting shaft 410 or the base 510 is provided with offset coupling portions; at this time, when the center rod 420 is placed in the receiving channel and is disposed at the coupling position of the connection shaft 410 and the base 510, the center rod 130 drives the coupling portion of the offset arrangement to be axially disposed along the connection shaft 110, thereby coupling the connection shaft 410 and the base 510.

More specifically, referring to fig. 16 and 17, the connecting shaft 410 has a first contact surface 411; the base 510 has a second contact surface 511 for contacting at least a portion of the first contact surface 411 when the connection shaft 410 and the base 510 are coupled; the surface of the first contact surface 411 is provided with a first through groove 412; the outer wall surface of the central rod 420 corresponds to the first through groove 412 and is a matching wall surface; wherein, when the central rod 420 is located at the coupling position of the connecting shaft 410 and the base 510, at least part of the wall surface of the first through groove 412 and the matching wall surface of the central rod 420 together form a preset channel 600 in a closed state; when the center pole 420 is located outside the coupling portion of the connecting shaft 410 and the base 510, the wall surface of the first through groove 412 is separated from the mating wall surface of the center pole 420, so that the preset channel 600 is in a non-closed state. Alternatively, the first through groove 412 is disposed on the second contact surface 511.

More specifically, referring to fig. 18 and 19, the connecting shaft 410 has a first contact surface 411; the base 510 has a second contact surface 511 for contacting at least a portion of the first contact surface 411 when the connection shaft 410 and the base 510 are coupled; the first contact surface 411 is provided with a second through groove 413, and the second contact surface 511 is provided with a third through groove 512; the outer wall surface of the center rod 420 corresponds to the second through groove 413 and the third through groove 512 and is a matching wall surface; when the central rod 420 is located at the coupling position of the connecting shaft 410 and the base 510, the wall surface of the second through slot 413 and the wall surface of the third through slot 512 together form a matching channel, the matching channel allows the first control wire to pass through, and the matching wall surface is located in the matching channel and forms a preset channel 600 in a closed state with part of the wall surface of the matching channel; when the central rod 420 is located outside the coupling portion of the connecting shaft 410 and the base 510, the mating wall is located outside the mating channel, so that the preset channel 600 is in a non-closed state. Alternatively, a portion of the outer wall surface of the center rod 420 corresponding to the second through groove 413 is a mating wall surface; alternatively, the portion of the outer wall surface of the center rod 420 corresponding to the third through groove 512 is a mating wall surface.

Specifically, in this embodiment, there is a region of overlap between the mating channel and the receiving channel, when the center rod 420 is disposed in the receiving channel and the center rod 420 is at the coupling position between the connecting shaft 410 and the base 510, the center rod 420 occupies at least a portion of the overlapping region, at this time, the mating wall is disposed in the mating channel, and the portion of the mating channel that is not occupied by the center rod 420 forms the preset channel 600 in a closed state.

In another alternative embodiment, the connecting shaft has a first contact surface; the base has a second contact surface for contacting at least a portion of the first contact surface when the connecting shaft and the base are coupled; a fourth groove is formed in the surface of the first contact surface or the surface of the second contact surface; a fifth through groove is formed in the part, corresponding to the fourth through groove, of the outer wall surface of the central rod; when the central rod is positioned at the coupling position of the connecting shaft and the base, the wall surface of the fourth through groove and the wall surface of the fifth through groove form a preset channel in a closed state together; when the central rod is outside the coupling position of the connecting shaft and the base, the wall surface of the fourth through groove is separated from the wall surface of the fifth through groove, so that the preset channel is in a non-closed state.

It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples of implementing the present application and that various changes in form and details may be made therein without departing from the spirit and scope of the present application. Various changes and modifications may be made by one skilled in the art without departing from the spirit and scope of the invention, and the scope of the invention shall be defined by the appended claims.

Claims

1. A prosthetic system comprising a delivery device and a prosthesis;

the conveying device comprises a connecting shaft and a first control wire;

the prosthesis comprises a base and a first movable piece, wherein the base is detachably coupled with the connecting shaft, and a preset channel is formed at the coupling position;

the first control wire is provided with a plurality of control wires which are connected in sequence: a first section for independently driving the first movable member to move, and a second section;

when the connecting shaft and the base are coupled, the preset channel is in a closed state, and the second section is restrained in the preset channel, so that the first section is restrained at the coupling position; when the connecting shaft and the base are separated, the preset channel is in a non-closed state, and the first control wire is allowed to be separated from the preset channel.

2. The prosthetic system of claim 1, wherein the implant is configured to receive the implant,

the connecting shaft is provided with a first contact surface;

the base has a second contact surface for contacting at least a portion of the first contact surface when the connecting shaft and the base are coupled;

the preset channel is positioned between the first contact surface and the second contact surface.

3. The prosthetic system of claim 2, wherein the implant is configured to receive the implant,

a first through groove is formed in the surface of the first contact surface or the surface of the second contact surface;

when the base is coupled with the connecting shaft, the wall surface of the first through groove and the corresponding part of the other contact surface jointly form the preset channel in a closed state;

when the base is separated from the connecting shaft, the wall surface of the first through groove is separated from the other contact surface, so that the preset channel is in a non-closed state.

4. The prosthetic system of claim 2, wherein the implant is configured to receive the implant,

the surface of the first contact surface is provided with a second through groove, and the surface of the second contact surface is provided with a third through groove;

when the base is coupled with the connecting shaft, the wall surface of the second through groove and the wall surface of the third through groove jointly form the preset channel in a closed state;

when the base is separated from the connecting shaft, the wall surface of the second through groove is separated from the wall surface of the third through groove, so that the preset channel is in a non-closed state.

5. The prosthetic system of claim 3 or 4, wherein the implant is configured to receive the implant,

the first contact surface and the second contact surface are configured to: the contact portion of the second contact surface with the first contact surface is such that the connecting shaft is restrained from moving in a radial direction of the connecting shaft relative to the base when the connecting shaft moves away from the base in the axial direction of the connecting shaft.

6. The prosthetic system of claim 5, wherein the implant is configured to receive the implant,

the first contact surface includes a distal first distal blocking surface, a proximal first proximal blocking surface, and a first sloped surface between the first distal blocking surface and the first proximal blocking surface; the second contact surface comprises a second distal blocking surface which is distal and is used for being corresponding to the first distal blocking surface, a second proximal blocking surface which is proximal and is used for being corresponding to the first proximal blocking surface, and a second inclined surface which is positioned between the second distal blocking surface and the second proximal blocking surface and is used for being jointed with the first inclined surface;

the maximum vertical distance of the first inclined surface to the edge of the connecting shaft becomes smaller as the distance to the distal end of the base becomes larger.

7. The prosthetic system of claim 6, wherein the implant is configured to receive the implant,

the first inclined surface is an inclined surface, a curved surface or a wavy surface.

8. The prosthetic system of claim 3 or 4, wherein the implant is configured to receive the implant,

the connecting shaft is provided with a first coupling part, the base is provided with a second coupling part, and the first coupling part or the second coupling part is arranged in an offset manner in the axial direction of the connecting shaft;

the first coupling portion and the second coupling portion are coupled when the coupling portion of the offset arrangement is driven to be arranged axially along the connecting shaft, the first contact surface being located on a side of the first coupling portion facing the second coupling portion, and the second contact surface being located on a side of the second coupling portion facing the first coupling portion.

9. The prosthetic system of claim 8, wherein the implant is configured to receive the implant,

one of the first coupling part and the second coupling part has a first protrusion, and the other has a first groove;

wherein the first protrusion is separated from the first groove when the first coupling portion or the second coupling portion is offset in the axial direction of the connection shaft; the first projection is received in the first recess when the biased coupling portion is urged to be disposed axially along the connecting shaft.

10. The prosthetic system of claim 9, wherein the implant is configured to receive the implant,

the first coupling part is also provided with a support piece biased inwards, and the first bulge is positioned at the distal end of the support piece and protrudes outwards in the direction perpendicular to the axis of the support piece; the base is provided with a second accommodating channel for accommodating the first coupling part, and the first groove is formed in the wall surface of the second accommodating channel; the first projection is received in the first recess when the support is urged to deflect such that the axis of the support is parallel to the axis of the connecting shaft;

or,

the first coupling part is also provided with an outwards biased supporting piece, and the first bulge is positioned at the distal end of the supporting piece and protrudes inwards perpendicular to the axial direction of the supporting piece; the first groove is arranged on the outer wall surface of the base; the first protrusion is received in the first groove when the support is urged to deflect such that the axis of the support is parallel to the axis of the connecting shaft.

11. The prosthetic system of claim 3 or 4, wherein the implant is configured to receive the implant,

one of the first contact surface and the second contact surface is provided with a second bulge, the other one of the first contact surface and the second contact surface is provided with a second groove, and the protruding direction of the second bulge and the sinking direction of the second groove are both radial directions of the connecting shaft;

when at least part of the first contact surface is in contact with the second contact surface, the second protrusion is embedded in the second groove.

12. The prosthetic system of claim 5, wherein the implant is configured to receive the implant,

the conveying device further includes: a central rod configured to remain at least radially relatively stationary with respect to the base when the central rod is at the coupling of the connecting shaft and the base to effect coupling of the connecting shaft and the base.

13. The prosthetic system of claim 8, wherein the implant is configured to receive the implant,

the conveying device further includes: a central rod configured to drive the coupling portion of the offset arrangement to be arranged axially along the connecting shaft when the central rod is located at the coupling of the connecting shaft and the base.

14. The prosthetic system of claim 1, wherein the implant is configured to receive the implant,

The diameter of the second section is greater than the diameter of the first section, or,

the first control wire further comprises a third section connected with one end, far away from the first section, of the second section, wherein the diameter of the second section is larger than that of any one of the first section and the third section, or the first control wire further comprises a third section connected with one end, far away from the first section, of the second section, and the diameter of the second section is smaller than that of the connecting part of any one of the first section and the third section and the second section.

15. The prosthetic system of claim 1, wherein the implant is configured to receive the implant,

the prosthesis further comprises a second movable member;

the first control wire further comprises a third section connected with one end, far away from the first section, of the second section, and the third section is used for independently driving the second movable piece to move;

when the connecting shaft and the base are coupled, the preset channel is in a closed state, and the second section is restrained in the preset channel, so that the third section is also restrained at the coupling position.

16. The prosthetic system of claim 15, wherein the implant is configured to receive the implant,

the radial dimension of the portion of any one of the first section and the third section connected with at least the second section is larger than the radial dimension of the second section, the minimum radial dimension of the preset channel in the closed state is larger than or equal to the radial dimension of the second section, and the maximum radial dimension of the preset channel in the closed state is smaller than the radial dimension of the portion of any one of the first section and the third section connected with at least the second section;

Or,

the radial dimension of the first section and the radial dimension of the third section are smaller than the radial dimension of the second section, the maximum radial dimension of the preset channel in the closed state is larger than or equal to the radial dimension of the second section, the minimum radial dimension of the preset channel in the closed state is smaller than or equal to the radial dimension of the second section, and the maximum radial dimension and the minimum radial dimension of the preset channel in the closed state are unequal.

17. The prosthetic system of claim 1, wherein the implant is configured to receive the implant,

the prosthesis further comprises a second movable member;

the conveying device further comprises a second control wire; the second control wire is provided with a plurality of control wires which are connected in sequence: a third section for independently driving the second movable member to move, and a fourth section;

when the preset channel is in a closed state, the fourth section is restrained in the preset channel, so that the connection part of the third section and the fourth section is restrained at the coupling part; the second control wire is allowed to separate from the preset tunnel when the preset tunnel is in a non-closed state.

18. The prosthetic system of claim 17, wherein the implant is configured to receive the implant,

When the preset channel is in a closed state, the part of the second section, which is close to one side of the first section, of the preset channel is a first part, the part of the other side of the second section is a second part, and the second part is positioned on one side, which is close to the third section, of the fourth section;

the radial dimension of the second section is greater than the radial dimension of the first section and greater than the radial dimension of the first portion of the preset channel in the closed state;

the radial dimension of the fourth segment is greater than the radial dimension of the third segment and greater than the radial dimension of the second portion of the predetermined path in the closed state.

19. The prosthetic system of any one of claims 15-18,

the prosthesis is a valve clip for clamping the edge of a native leaflet;

the first movable part is a first clamping arm, the second movable part is a second clamping arm, the first clamping arm and the second clamping arm rotate relative to the axis of the base, and,

the first section is movably connected to the first clamping arm and the second section is movably connected to the second clamping arm.

20. The prosthetic system of claim 19, wherein the prosthetic device comprises a prosthetic device,

The first section extends distally from the preset channel and, after extending to the location of the first clamping arm, extends proximally back towards the delivery device to form a curved portion; the curved portion is interpenetrating with the first clamping arm or an accessory provided to the first clamping arm.

21. The prosthetic system of claim 20, wherein the prosthetic device comprises a prosthetic device,

the first clamping arm is provided with an accessory, the accessory is a fixing wire, the fixing wire is arranged on the first clamping arm, and the fixing wire forms a body which is used for interpenetrating with the bending part.

22. The prosthetic system of claim 21, wherein the prosthetic device comprises a prosthetic device,

the first clamping arm is provided with a first through hole, the fixing wire is provided with a fixing knot, the body is connected with the fixing knot and is provided with a second through hole in a winding mode, the body penetrates through the first through hole from one side, far away from the base, of the first clamping arm, the fixing knot is fixed on one side, far away from the base, of the first clamping arm, and the fixing knot is configured to be incapable of penetrating through the first through hole.

23. A prosthetic system comprising a delivery device and a prosthesis;

The conveying device comprises a connecting shaft, a central rod and a first control wire;

the prosthesis comprises a base and a first movable member, wherein the base is coupled to the connecting shaft when the central rod is located at the coupling of the connecting shaft to the base;

when the central rod is positioned at the coupling position of the connecting shaft and the base, a preset channel in a closed state is formed between the central rod and the connecting shaft and/or the base at the coupling position, and the second section is restrained in the preset channel, so that the first section is restrained at the coupling position; when the center rod is positioned outside the coupling position of the connecting shaft and the base, the preset channel is in a non-closed state, and the first control wire is allowed to be separated from the preset channel.

24. The prosthetic system of claim 23, wherein the prosthetic device comprises a prosthetic device,

the connecting shaft is provided with a first contact surface;

the part of the outer wall surface of the central rod corresponding to the first through groove is a matched wall surface;

when the central rod is positioned at the coupling position of the connecting shaft and the base, at least part of the wall surface of the first through groove and the matched wall surface of the central rod form the preset channel in a closed state together;

when the center rod is positioned outside the coupling position of the connecting shaft and the base, the wall surface of the first through groove is separated from the matching wall surface of the center rod, so that the preset channel is in a non-closed state.

25. The prosthetic system of claim 23, wherein the prosthetic device comprises a prosthetic device,

the connecting shaft is provided with a first contact surface;

the first contact surface is provided with a second through groove, and the second contact surface is provided with a third through groove;

the part of the outer wall surface of the central rod corresponding to the second channel and/or the third channel is a matched wall surface;

when the central rod is positioned at the coupling position of the connecting shaft and the base, the wall surface of the second through groove and the wall surface of the third through groove jointly form a matching channel, the matching channel allows the first control wire to pass through, and the matching wall surface is positioned in the matching channel and forms the preset channel in a closed state with part of the wall surface of the matching channel;

When the center rod is outside the coupling part of the connecting shaft and the base, the matching wall surface is outside the matching channel, so that the preset channel is in a non-closed state.

26. The prosthetic system of claim 23, wherein the prosthetic device comprises a prosthetic device,

the connecting shaft is provided with a first contact surface;

a fourth groove is formed in the surface of the first contact surface or the surface of the second contact surface;

a fifth through groove is formed in the part, corresponding to the fourth through groove, of the outer wall surface of the central rod;

when the center rod is positioned at the coupling position of the connecting shaft and the base, the wall surface of the fourth through groove and the wall surface of the fifth through groove jointly form the preset channel in a closed state;

when the center rod is outside the coupling position of the connecting shaft and the base, the wall surface of the fourth through groove is separated from the wall surface of the fifth through groove, so that the preset channel is in a non-closed state.