CN117653050A - Medical equipment and cardiovascular parameter calculation method - Google Patents

Abstract

The application provides a medical device and a calculation method of cardiovascular parameters, wherein the method comprises the following steps: acquiring pulse signals of a plurality of cardiac cycles of a patient; acquiring physiological signals of a plurality of cardiac cycles, which are homologous to the pulse signals and are used for reflecting the heart beats of the patient, from at least one other path; synchronously comparing the pulse signals and the physiological signals to determine the pulse signals and the physiological signals belonging to the same cardiac cycle; determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to pulse signals and/or physiological signals respectively corresponding to the cardiac cycles; when irregular cardiac cycles exist in the cardiac cycles, correcting pulse signals of the cardiac cycles according to abnormal conditions of physiological signals, and calculating cardiovascular parameters according to the corrected pulse signals; alternatively, the cardiovascular parameter is calculated using pulse signals outside of a plurality of cardiac cycles. The method can obtain more accurate cardiovascular parameters so as to reduce interference of other factors.

Description

Medical equipment and cardiovascular parameter calculation method

Technical Field

The invention relates to the technical field of medical treatment, in particular to medical equipment and a cardiovascular parameter calculating method.

Background

The physiological parameters obtained by processing the human vital sign signals have wide application. However, these vital sign signals are often subject to disturbances such as noise, artifacts, etc. causing errors in the physiological parameters. Taking an arterial pressure signal as an example, noise or artifacts in the arterial pressure signal directly affect the accuracy and reliability of a blood movement index calculated by the arterial pressure, so that the noise in the arterial pressure signal needs to be detected; however, since the arterial pressure signal itself has a real physiological variation, it is difficult to identify noise, which results in inaccurate cardiovascular parameters calculated from the arterial pressure parameters. How to better reduce the influence of noise or artifacts in arterial pressure signals, etc. to improve the accuracy of calculating cardiovascular parameters is one of the problems to be improved or solved at present.

Disclosure of Invention

The invention mainly solves the technical problem of providing the medical equipment and the calculation method of the cardiovascular parameters, and the medical equipment applying the calculation method can obtain more accurate cardiovascular parameters.

To solve the above technical problem, in one embodiment of the present application, there is provided a medical device including:

A pulse sensor for acquiring pulse signals of a plurality of cardiac cycles of a patient;

a physiological parameter sensor for acquiring physiological signals of a plurality of said cardiac cycles reflecting the heart beat of the patient, of at least one other path homologous to said pulse signal;

the processor is used for synchronously comparing the pulse signals with the physiological signals, determining the pulse signals and the physiological signals belonging to the same cardiac cycle, and determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the pulse signals and/or the physiological signals respectively corresponding to the cardiac cycles, wherein the physiological signals and/or the pulse signals in the irregular cardiac cycles are abnormal;

when irregular cardiac cycles exist in a plurality of cardiac cycles, correcting pulse signals of the cardiac cycles according to abnormal conditions of the physiological signals, and calculating cardiovascular parameters according to the corrected pulse signals; alternatively, the cardiovascular parameter is calculated using pulse signals outside of the plurality of cardiac cycles.

In some embodiments, said synchronizing said pulse signal and said physiological signal, determining said pulse signal and said physiological signal attributed to the same cardiac cycle comprises:

Identifying a first instant of occurrence of each of the cardiac cycles in the pulse signal;

identifying a second instant of occurrence of each of the cardiac cycles in the physiological signal;

determining the first time and the second time corresponding to the same cardiac cycle, wherein the time difference between the first time and the second time corresponding to the same cardiac cycle is within a preset range;

and determining the pulse signal and the physiological signal in the same cardiac cycle corresponding to the first time and the second time of the same cardiac cycle as the pulse signal and the physiological signal belonging to the same cardiac cycle.

In some embodiments, said identifying a first instant of occurrence of each of said cardiac cycles in said pulse signal comprises:

extracting an occurring P wave crest from the pulse signal;

and taking the moment of occurrence of each P wave crest as the first moment of occurrence of each cardiac cycle.

In some embodiments, said identifying a second instant of occurrence of each of said cardiac cycles in said physiological signal comprises:

extracting an emerging R-wave peak from the physiological signal;

and taking the moment of occurrence of each R wave crest as the second moment of occurrence of each cardiac cycle.

In some embodiments, the determining whether an irregular cardiac cycle exists in a plurality of cardiac cycles according to the pulse signal and/or the physiological signal respectively corresponding to each cardiac cycle includes:

extracting cardiac cycle information of each cardiac cycle according to the pulse signals corresponding to each cardiac cycle, wherein the cardiac cycle information is used for representing the characteristics of the cardiac cycle;

and obtaining comparison results of the cardiac cycle information of each cardiac cycle and the cardiac cycle information of the set control cardiac cycle, and determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the comparison results.

In some embodiments, the cardiac cycle information includes at least one of an amplitude, an interval, and a QRS wave width of the cardiac cycle.

In some embodiments, the determining whether an irregular cardiac cycle exists in a plurality of cardiac cycles according to the pulse signal and/or the physiological signal respectively corresponding to each cardiac cycle includes:

and acquiring a heart beat classification result and an arrhythmia recognition result corresponding to each cardiac cycle according to the physiological signals corresponding to each cardiac cycle, and determining whether irregular cardiac cycles exist in the cardiac cycles according to the heart beat classification result and the arrhythmia recognition result corresponding to each cardiac cycle.

In some embodiments, the abnormal condition of the physiological signal includes whether there is an abnormality and a degree of abnormality, the correcting the pulse signals of the plurality of cardiac cycles according to the abnormal condition of the physiological signal, and calculating a cardiovascular parameter according to the corrected pulse signals includes:

when the physiological signals in the cardiac cycles are abnormal, or when the physiological signals in the cardiac cycles are abnormal and the degree of the abnormality is smaller than a preset degree, the pulse signals in the cardiac cycles are corrected according to the physiological signals, and cardiovascular parameters are calculated according to the corrected pulse signals.

In some embodiments, the abnormal condition of the physiological signal includes the presence and extent of abnormality, and the calculating the cardiovascular parameter using pulse signals outside of the plurality of cardiac cycles based on the abnormal condition of the physiological signal includes:

and when the physiological signals in the plurality of cardiac cycles are abnormal, or when the physiological signals in the plurality of cardiac cycles are abnormal and the degree of the abnormality is larger than a preset degree, calculating cardiovascular parameters by using pulse signals outside the plurality of cardiac cycles.

In some embodiments, when there is no abnormality in the physiological signals in the plurality of cardiac cycles, correcting pulse signals of the plurality of cardiac cycles according to the physiological signals, and calculating a cardiovascular parameter according to the corrected pulse signals, including:

removing pulse signals corresponding to the irregular cardiac cycles from the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals; or alternatively

And replacing the corresponding pulse signals with the physiological signals corresponding to the irregular cardiac cycles in the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

In some embodiments, when there is an abnormality in the physiological signals in the plurality of cardiac cycles and the abnormality is less than a preset level, correcting pulse signals in the plurality of cardiac cycles according to the physiological signals, and calculating a cardiovascular parameter according to the corrected pulse signals, including:

removing pulse signals corresponding to abnormal physiological signals from the pulse signals of the plurality of cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

To solve the above technical problem, another embodiment of the present application provides a method for calculating a cardiovascular parameter, including:

acquiring pulse signals of a plurality of cardiac cycles of a patient;

acquiring physiological signals of a plurality of cardiac cycles of which at least one other path homologous to the pulse signals is used for reflecting heart beats of a patient;

synchronizing the pulse signal and the physiological signal, and determining the pulse signal and the physiological signal belonging to the same cardiac cycle;

determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the pulse signals and/or the physiological signals respectively corresponding to the cardiac cycles, wherein the physiological signals and/or the pulse signals in the irregular cardiac cycles are abnormal;

when irregular cardiac cycles exist in a plurality of cardiac cycles, correcting pulse signals of the cardiac cycles according to abnormal conditions of the physiological signals, and calculating cardiovascular parameters according to the corrected pulse signals; alternatively, the cardiovascular parameter is calculated using pulse signals outside of the plurality of cardiac cycles.

In some embodiments, said synchronizing said pulse signal and said physiological signal, determining said pulse signal and said physiological signal attributed to the same cardiac cycle comprises:

Identifying a first instant of occurrence of each of the cardiac cycles in the pulse signal;

identifying a second instant of occurrence of each of the cardiac cycles in the physiological signal;

determining the first time and the second time corresponding to the same cardiac cycle, wherein the time difference between the first time and the second time corresponding to the same cardiac cycle is within a preset range;

and determining the pulse signal and the physiological signal in the same cardiac cycle corresponding to the first time and the second time of the same cardiac cycle as the pulse signal and the physiological signal belonging to the same cardiac cycle.

In some embodiments, said identifying a first instant of occurrence of each of said cardiac cycles in said pulse signal comprises:

extracting an occurring P wave crest from the pulse signal;

and taking the moment of occurrence of each P wave crest as the first moment of occurrence of each cardiac cycle.

In some embodiments, said identifying a second instant of occurrence of each of said cardiac cycles in said physiological signal comprises:

extracting an emerging R-wave peak from the physiological signal;

and taking the moment of occurrence of each R wave crest as the second moment of occurrence of each cardiac cycle.

In some embodiments, the determining whether an irregular cardiac cycle exists in a plurality of cardiac cycles according to the pulse signal and/or the physiological signal respectively corresponding to each cardiac cycle includes:

extracting cardiac cycle information of each cardiac cycle according to the pulse signals corresponding to each cardiac cycle, wherein the cardiac cycle information is used for representing the characteristics of the cardiac cycle;

and obtaining comparison results of the cardiac cycle information of each cardiac cycle and the cardiac cycle information of the set control cardiac cycle, and determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the comparison results.

In some embodiments, the cardiac cycle information includes at least one of an amplitude, an interval, and a QRS wave width of the cardiac cycle.

In some embodiments, the determining whether an irregular cardiac cycle exists in a plurality of cardiac cycles according to the pulse signal and/or the physiological signal respectively corresponding to each cardiac cycle includes:

and acquiring a heart beat classification result and an arrhythmia recognition result corresponding to each cardiac cycle according to the physiological signals corresponding to each cardiac cycle, and determining whether irregular cardiac cycles exist in the cardiac cycles according to the heart beat classification result and the arrhythmia recognition result corresponding to each cardiac cycle.

In some embodiments, the abnormal condition of the physiological signal includes whether there is an abnormality and a degree of abnormality, the correcting the pulse signals of the plurality of cardiac cycles according to the abnormal condition of the physiological signal, and calculating a cardiovascular parameter according to the corrected pulse signals includes:

when the physiological signals in the cardiac cycles are abnormal, or when the physiological signals in the cardiac cycles are abnormal and the degree of the abnormality is smaller than a preset degree, the pulse signals in the cardiac cycles are corrected according to the physiological signals, and cardiovascular parameters are calculated according to the corrected pulse signals.

In some embodiments, the abnormal condition of the physiological signal includes the presence and extent of abnormality, and the calculating the cardiovascular parameter using pulse signals outside of the plurality of cardiac cycles based on the abnormal condition of the physiological signal includes:

and when the physiological signals in the plurality of cardiac cycles are abnormal, or when the physiological signals in the plurality of cardiac cycles are abnormal and the degree of the abnormality is larger than a preset degree, calculating cardiovascular parameters by using pulse signals outside the plurality of cardiac cycles.

In some embodiments, when there is no abnormality in the physiological signals in the plurality of cardiac cycles, correcting pulse signals of the plurality of cardiac cycles according to the physiological signals, and calculating a cardiovascular parameter according to the corrected pulse signals, including:

removing pulse signals corresponding to the irregular cardiac cycles from the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals; or alternatively

And replacing the corresponding pulse signals with the physiological signals corresponding to the irregular cardiac cycles in the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

In some embodiments, when there is an abnormality in the physiological signals in the plurality of cardiac cycles and the abnormality is less than a preset level, correcting pulse signals in the plurality of cardiac cycles according to the physiological signals, and calculating a cardiovascular parameter according to the corrected pulse signals, including:

removing pulse signals corresponding to abnormal physiological signals from the pulse signals of the plurality of cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

In the above embodiment, at least one other physiological signal homologous to the pulse signal is obtained, whether an irregular cardiac cycle exists in a plurality of cardiac cycles is determined by at least one of the physiological signal and the pulse signal, and when the irregular cardiac cycle exists in the plurality of cardiac cycles, the pulse signal of the plurality of cardiac cycles is corrected according to the abnormal condition of the physiological signal, and the cardiovascular parameter is calculated according to the corrected pulse signal, or the pulse signal other than the plurality of cardiac cycles is used to calculate the cardiovascular parameter, and the accuracy of the cardiovascular parameter can be improved by correcting the pulse signal, and when the accurate cardiovascular parameter cannot be obtained by the correction means, the pulse signal other than the plurality of cardiac cycles can be used to calculate the cardiovascular parameter, so as to avoid adopting the unsuitable cardiovascular parameter.

Drawings

FIG. 1 is a diagram of a processing system architecture of a multi-parameter monitor according to one embodiment;

FIG. 2 is a block diagram of a processing system of a single parameter monitor according to one embodiment;

FIG. 3 is a schematic diagram of another embodiment of a monitor networking system;

FIG. 4 is a flowchart of a method for calculating cardiovascular parameters according to one embodiment;

FIG. 5 is a schematic waveform diagram of an electrocardiographic signal and a pulse signal according to an embodiment;

FIG. 6 is a schematic diagram of pulse signal anomalies over multiple cardiac cycles according to one embodiment;

FIG. 7 is a flowchart of identifying whether an abnormality exists in an electrocardiographic signal according to one embodiment;

fig. 8 is a flow chart of classifying QRS waves according to one embodiment;

FIG. 9 is a schematic diagram illustrating calculation of PPV of pulse pressure variation rate according to an embodiment;

FIG. 10 is a schematic diagram showing an embodiment in which the degree of abnormality of the central electrical signal in a plurality of cardiac cycles does not exceed a preset degree;

FIG. 11 is a schematic diagram of an embodiment in which the degree of abnormality of the electrical signal exceeds a preset degree in the center of a plurality of cardiac cycles;

FIG. 12 is a schematic diagram of another embodiment of a plurality of heart cycle center electrical signals having an abnormality level exceeding a preset level.

Detailed Description

The invention will be described in further detail below with reference to the drawings by means of specific embodiments. Wherein like elements in different embodiments are numbered alike in association. In the following embodiments, numerous specific details are set forth in order to provide a better understanding of the present application. However, one skilled in the art will readily recognize that some of the features may be omitted, or replaced by other elements, materials, or methods in different situations. In some instances, some operations associated with the present application have not been shown or described in the specification to avoid obscuring the core portions of the present application, and may not be necessary for a person skilled in the art to describe in detail the relevant operations based on the description herein and the general knowledge of one skilled in the art.

Furthermore, the described features, operations, or characteristics of the description may be combined in any suitable manner in various embodiments. Also, various steps or acts in the method descriptions may be interchanged or modified in a manner apparent to those of ordinary skill in the art. Thus, the various orders in the description and drawings are for clarity of description of only certain embodiments, and are not meant to be required orders unless otherwise indicated.

The numbering of the components itself, e.g. "first", "second", etc., is used herein merely to distinguish between the described objects and does not have any sequential or technical meaning. The terms "coupled" and "connected," as used herein, are intended to encompass both direct and indirect coupling (coupling), unless otherwise indicated.

The medical device according to the present application is not limited to a monitor, but includes an invasive/noninvasive ventilator having a monitoring function, a nurse station, a central station, and the like. The present application is mainly described with reference to a monitor.

As shown in fig. 1, a system frame diagram of a parameter processing module in a multi-parameter monitor is provided. The multi-parameter monitor may have a separate housing, and the housing panel may have a sensor interface area thereon, where the sensor interface area may integrate a plurality of sensor interfaces for connection with external respective physiological parameter sensor accessories 111, where the physiological parameter sensor accessories 111 include at least a physiological sensor and a pulse sensor, where the physiological sensor is configured to acquire physiological signals of a patient over a plurality of cardiac cycles, including but not limited to an electrocardiographic signal (ECG), an electrical impedance signal (ICG), a ballistocardiographic signal (BCG), and the like. The pulse sensor is used to acquire pulse signals of a patient synchronized with physiological signals, including but not limited to pulse volume wave (PPG), invasive arterial pressure (invasive arterial pressure), and the like. The housing panel may also include a small IXD display area, a display 119, input interface circuitry 121, and alarm circuitry 120 (e.g., LED alarm area), among others. The parameter processing module has an external communication and power interface 116 for communicating with and retrieving power from the host. The parameter processing module can also support an externally inserted parameter module, and can form a plug-in type monitor host through inserting the parameter module to serve as a part of the monitor, and can also be connected with the host through a cable, and the externally inserted parameter module serves as an external accessory of the monitor.

The internal circuit of the parameter processing module is disposed in the housing, as shown in fig. 1, and includes at least two signal acquisition circuits 112 corresponding to physiological parameters, a front end signal processor 113 and a main processor 115, where the signal acquisition circuits 112 may be selected from an electrocardiograph circuit, a respiratory circuit, a body temperature circuit, an oximetry circuit, a noninvasive blood pressure circuit, an invasive blood pressure circuit, etc., the signal acquisition circuits 112 are respectively electrically connected to corresponding sensor interfaces for electrically connecting to sensor accessories 111 corresponding to different physiological parameters, the output ends of the sensor accessories are coupled to the front end signal processor 113, the communication port of the front end signal processor 113 is coupled to the main processor 115, and the main processor 115 is electrically connected to the external communication and power interface 116. The sensor accessory 111 and the signal acquisition circuit 112 corresponding to various physiological parameters can be general circuits in the prior art, and the front-end signal processor 113 performs sampling and analog-to-digital conversion of the output signal of the signal acquisition circuit 112 and outputs control signals to control the measurement process of the physiological signals, wherein the physiological parameters include but are not limited to: electrocardiography, respiration, body temperature, blood oxygen, noninvasive blood pressure, invasive blood pressure parameters, and the like. The front-end signal processor 113 may be implemented by a single chip or other semiconductor devices, for example, may be an LPC2136 of PHLIPS company, or an ADuC7021 of ADI, or may be implemented by an ASIC or FPGA. The front-end signal processor 113 may be powered by an isolated power source, and the sampled data may be simply processed and packaged and sent to the main processor 115 via an isolated communication interface, e.g., the front-end signal processor 113 may be coupled to the main processor 115 via the isolated power source and the communication interface 114. The reason that the front-end signal processor 113 is powered by the isolated power supply is that the DC/DC power supply isolated by the transformer plays a role in isolating the patient from the power supply equipment, and the main purpose is that: 1. isolating the patient, and floating the application part through an isolating transformer to ensure that the leakage current of the patient is small enough; 2. the voltage or energy during defibrillation or electrotome application is prevented from affecting the board card and devices (ensured by creepage distance and electric gap) of intermediate circuits such as a main control board. Of course, the front-end signal processor 113 may also be connected to the main processor 115 by a cable. The main processor 115 is configured to complete calculation of physiological parameters, and send the calculation result and waveform of the parameters to a host (such as a host with a display, a PC, a central station, etc.) through the external communication and power interface 116; wherein the main processor 115 may be connected to the external communication and power interface 116 by a cable for communication and/or power extraction; the parameter processing module may further include a power supply and battery management circuit 117, where the power supply and battery management circuit 117 is powered from the host computer through the external communication and power interface 116, and is processed and then supplied to the main processor 115, such as rectification and filtering; the power and battery management circuitry 117 may also monitor, manage and power protect power drawn from the host through the external communication and power interface 116. The external communication and power interface 116 may be one or a combination of local area network interfaces formed by Ethernet (Ethernet), token Ring (Token Ring), token Bus (Token Bus) and backbone network Fiber Distributed Data Interface (FDDI) serving as the three networks, or one or a combination of wireless interfaces such as infrared, bluetooth, wifi and WMTS communication, or one or a combination of wired data connection interfaces such as RS232 and USB. The external communication and power interface 116 may also be one or a combination of both a wireless data transfer interface and a wired data transfer interface. The host computer can be any one of a host computer of a monitor, an electrocardiograph, an ultrasonic diagnostic apparatus, a computer and the like, and can form a monitoring device by installing matched software. The host can also be communication equipment, such as a mobile phone, and the parameter processing module sends data to the mobile phone supporting Bluetooth communication through the Bluetooth interface so as to realize remote transmission of the data. After the main processor 115 completes the calculation of the physiological parameter, it may also determine whether the physiological parameter is abnormal, and if so, may alarm through the alarm circuit 120. The memory 118 may store intermediate and final data for the monitor, as well as program instructions or code for execution by the main processor 115 or the like.

As shown in fig. 2, a processing system architecture for a monitor of a single physiological parameter is provided. The same can be found in the above.

As shown in fig. 3, a networking system for monitors used in a hospital is provided, and the system can be used for integrally storing data of the monitors, centrally managing patient information and nursing information, storing the patient information and the nursing information in an associated mode, and conveniently storing historical data and carrying out associated alarm. In the system shown in fig. 3, one bedside monitor 212 may be provided for each patient bed, and the bedside monitor 212 may be the multi-parameter monitor or a plug-in monitor described above. In addition, each bedside monitor 212 can be paired with a portable monitor 213, the portable monitor 213 provides a simple and portable parameter processing module, but the portable monitor 213 is worn on the patient body to carry out mobile monitoring on the corresponding patient, and after wired or wireless communication with the bedside monitor 212 through the portable monitor 213, physiological data generated by the mobile monitoring can be transmitted to the bedside monitor 212 for display, or transmitted to the central station 211 through the bedside monitor 212 for viewing by doctors or nurses, or transmitted to the data server 215 through the bedside monitor 212 for storage. In addition, the portable monitoring instrument 213 can also transmit the physiological data generated by the mobile monitoring to the central station 211 for storage and display directly through the wireless network node 214 disposed in the hospital, or transmit the physiological data generated by the mobile monitoring to the data server 215 for storage through the wireless network node 214 disposed in the hospital. It can be seen that the data corresponding to the physiological parameters displayed on the bedside monitor 212 can originate from a sensor accessory directly connected to the patient above the monitor, or from the portable monitor 213, or from a data server.

Based on the monitor, fig. 4 provides a method for calculating cardiovascular parameters, which includes the steps of:

step S100, pulse signals of a plurality of cardiac cycles of a patient are acquired.

In this step, the pulse signal may be an invasive arterial pressure (IBP signal), and in other embodiments, the pulse signal may also be a pulse volume wave (PPG), or the like.

Step S200, acquiring a physiological signal of a plurality of cardiac cycles, which is homologous to the pulse signal and is used for reflecting the heart beat of the patient, from at least one other path.

Homology to pulse signals means that both physiological signals and pulse signals originate from heart beats and are therefore homologous signals. The physiological signals include, but are not limited to, an electrocardiographic signal (ECG), an electrical impedance signal (impedance signal), and a ballistocardiographic signal (BCG), etc., and in some of the following description and drawings, the physiological signals are electrocardiographic signals, and the pulse signals are IBP signals.

Step S300, the pulse signals and the physiological signals are synchronously compared, and the pulse signals and the physiological signals belonging to the same cardiac cycle are determined.

As shown in fig. 5, the IBP signal is about 150ms (there is a weak difference between individuals) slower in time than the ECG signal, and this difference is substantially constant for regular heart beats of the same individual, and furthermore, the period of the ECG signal corresponding to the same heart beat is the same as the period time of the IPB signal, so that the synchronization relationship between the IPB signal and the ECG signal can be analyzed. Specifically, step S300 includes:

Step S310, a first moment of occurrence of each cardiac cycle in the pulse signal is identified.

In some embodiments, the P-wave peaks appearing in the pulse signal are first extracted, and then the time at which each P-wave peak appears is taken as the first time at which each cardiac cycle appears, that is, the P-wave peak is taken as a representative of the cardiac cycle in the pulse signal, and the occurrence of the P-wave peak means that the cardiac cycle appears. In other embodiments, the time when the waveform feature of other types appears may also be used as the first time, for example, the time when the start point of the P-wave appears may be used as the first time.

Step S320, identify the second moment of occurrence of each cardiac cycle in the physiological signal.

In some embodiments, the R-wave peaks appearing in the physiological signal are first extracted, and then the time at which each R-wave peak appears is taken as the second time at which each cardiac cycle appears, that is, the R-wave peak is taken as a representative of the cardiac cycle in the physiological signal, and the occurrence of the R-wave peak means that the cardiac cycle appears. In other embodiments, the time when the other type of waveform feature occurs may also be taken as the second time, for example, when the first time is the time when the start point of the P wave occurs, the time when the start point of the R wave occurs may be taken as the second time.

Step S330, determining a first time and a second time corresponding to the same cardiac cycle, where a time difference between the first time and the second time corresponding to the same cardiac cycle is within a preset range.

Wherein, the preset range may be 150ms above, and for a certain first time, if a second time is identified within the preset range, it means that the cardiac cycle represented by the first time and the cardiac cycle represented by the second time are the same cardiac cycle, so that the first time and the second time corresponding to the same cardiac cycle can be determined.

Step S340, determining the pulse signal and the physiological signal in the same cardiac cycle corresponding to the first time and the second time of the same cardiac cycle as the pulse signal and the physiological signal belonging to the same cardiac cycle.

For example, the cardiac cycle represented by a certain first time and a certain second time is the same cardiac cycle, the pulse signal corresponding to the cardiac cycle at the first time is extracted from the pulse signal, and the physiological signal corresponding to the cardiac cycle at the second time is extracted from the physiological signal, so that the pulse signal and the physiological signal which belong to the same cardiac cycle can be obtained.

Step 400, determining whether an irregular cardiac cycle exists in the plurality of cardiac cycles according to pulse signals and/or physiological signals respectively corresponding to the cardiac cycles, wherein the physiological signals and/or pulse signals in the irregular cardiac cycle are abnormal. If there are no irregular cardiac cycles in the plurality of cardiac cycles, step S500 is performed, otherwise step S600 is performed.

Fig. 6 is a schematic diagram showing an abnormality in the pulse signal in an embodiment. In some embodiments, cardiac cycle information characterizing a cardiac cycle of each cardiac cycle may be extracted from a pulse signal, where the cardiac cycle information includes, but is not limited to, at least one of an amplitude, an interval, and a QRS wave width of the cardiac cycle, where the amplitude of the cardiac cycle refers to a maximum value of the pulse signal in the cardiac cycle, and when a pulse waveform is generated from the pulse signal, that is, a peak value of the pulse waveform, an interval of the cardiac cycle may be any one of a PP interval, an RR interval, and the like, where the PP interval refers to a time period between two P waves between two cardiac cycles; the QRS wave width of a cardiac cycle refers to the length of the time period of the QRS wave in that cardiac cycle.

After the cardiac cycle information of a certain cardiac cycle is obtained, the cardiac cycle information of the cardiac cycle is compared with the cardiac cycle information of a set control cardiac cycle, and whether the cardiac cycle is an irregular cardiac cycle can be judged according to the comparison result. The reference cardiac cycle may refer to a pre-stored normal cardiac cycle, and if the cardiac cycle information of a certain cardiac cycle is excessively different from the cardiac cycle information of the reference cardiac cycle, the cardiac cycle may be determined to be an irregular cardiac cycle, otherwise, the cardiac cycle may be determined to be not abnormal from the point of view of the pulse signal. The above-described comparison may be employed for each of a plurality of cardiac cycles to determine whether an irregular cardiac cycle exists in the plurality of cardiac cycles based on the pulse signal.

In some embodiments, when the physiological signal is an electrocardiograph signal (ECG), for any cardiac cycle, the electrocardiograph signal of the cardiac cycle may be processed in a manner as shown in fig. 7, so as to obtain information such as a heartbeat classification result and an arrhythmia recognition result corresponding to the cardiac cycle, and determine whether the cardiac cycle is an irregular cardiac cycle according to the information such as the heartbeat classification result and the arrhythmia recognition result. Specifically, after the original electrocardiosignal is obtained, noise removal, filtering and other treatments are performed on the electrocardiosignal, then the signal quality of the electrocardiosignal is judged, and a preset QRS wave detection and classification algorithm is adopted to identify the QRS wave, one detection and identification mode can be that the electrocardiosignal is compared with a template, according to the comparison result, which QRS wave is a normal QRS wave can be analyzed, as shown in fig. 8, according to the comparison, QRS wave (1) is a normal QRS wave, QRS wave (2) is an abnormal QRS wave, and QRS wave (3) is an unclassified QRS wave. Based on the identified QRS wave, the current heart rate, whether or not there is currently arrhythmia, and the offset value of the ST segment (the flat line from the end of the QRS complex to the beginning of the T wave) can be calculated.

It should be noted that, in this embodiment, the abnormality recognition of the electrocardiographic signal or the pulse signal is not improved, so that, for those skilled in the art, the technical solution of this embodiment may be implemented by adopting the existing abnormality recognition algorithm of the electrocardiographic signal and the existing abnormality recognition algorithm of the pulse signal. For example, another method of detecting irregular cardiac cycles in the prior art is to analyze the duration of the different phases of the cardiac cycle, e.g., compare the duration of the whole cardiac cycle (i.e., beat heart rate), the duration of systole, the duration of diastole, the duration of systole rise, the duration of systole fall and/or the duration of whole fall. For another example, yet another method of detecting irregular cardiac cycles is to analyze the location of dicrotic notch of the arterial waveform/signal. For example, the position of the dicrotic notch versus the maximum systolic pressure and the position of the dicrotic notch versus the diastolic pressure (the minimum pressure of the cardiac cycle preceding the maximum systolic pressure) are analyzed. Further, the difference between the value of the diastolic pressure corresponding to the beginning of the cardiac cycle and the value of the maximum pressure corresponding to the cardiac cycle may be used to determine whether the cardiac cycle is irregular.

Step S500, calculating cardiovascular parameters according to pulse signals of a plurality of cardiac cycles.

Cardiovascular parameters referred to in this example include, but are not limited to, pulse pressure variability PPV, cardiac output CO, heart beat variability SVV, systemic vascular resistance SVR, and the like. The following illustrates some ways of calculating the cardiovascular parameters.

In some embodiments, the means for obtaining the pulse pressure variability comprises:

and obtaining the blood pressure value of the patient according to the pulse signals in the preset time period, and obtaining the systolic pressure and the diastolic pressure of the patient based on the obtained blood pressure value. In this embodiment, the preset time period is a plurality of cardiac cycles, that is, a plurality of cardiac cycles may obtain a corresponding pulse pressure variation rate.

The difference between systolic and diastolic pressures is calculated to obtain the pulse pressure difference PP.

The maximum value PPmax and the minimum value PPmin of the pulse pressure difference PP in the predetermined period of time are searched, for example, as shown in fig. 9, the pulse pressure difference PP in the predetermined period of time can be formed into a waveform chart distributed along the time axis, and the pulse pressure variation rate PPV is calculated according to the maximum value PPmax and the minimum value PPmin. In this embodiment, the calculation formula of the pulse pressure variation rate PPV is as follows:

PPV＝2*(PPmax-PPmin)/(PPmax+PPmin)。

in other embodiments, other algorithms may be used for pulse pressure variability PPV, such as ppv=ppmax-PPmin, or ppv= (PPmax-PPmin)/(ppmax+ppmin).

In other embodiments, for a plurality of cardiac cycles, the maximum value SVmax of the cardiac output and the minimum value SVmin of the cardiac output in the plurality of cardiac cycles may be obtained from the pulse signal, and then the cardiac variability may be calculated by the following formula:

SVV＝100*{(SVmax-SVmin)/[0.5(SVmax+SVmin)]}。

step S600, judging whether the physiological signal corresponding to the irregular cardiac cycle is abnormal, if so, executing step S700, otherwise, executing step S800 or executing step S900.

In this step, the abnormal recognition result of the physiological signal during the irregular cardiac cycle in step S400 may be directly used, or the physiological signal during the irregular cardiac cycle may be detected, so as to determine whether the physiological signal is abnormal.

For an irregular cardiac cycle, if there is no abnormality in the physiological signal in the irregular cardiac cycle, there is an abnormality in the natural pulse signal, that is, in this embodiment, if there is an abnormality in the pulse signal in the irregular cardiac cycle, step S800 may be performed, or step S900 may be performed. If there is an abnormality in the physiological signal but there is no abnormality in the pulse signal, it is possible to select whether to perform step S800 or step S900 according to the abnormality of the physiological signal.

Step S700, identifying the abnormality degree of the physiological signal in a plurality of cardiac cycles, if the abnormality degree of the physiological signal does not exceed the preset degree, executing step S800, otherwise executing step S900.

The meaning of the degree of abnormality of the physiological signal over a plurality of cardiac cycles in some embodiments is described below with respect to an electrocardiographic signal.

Specifically, the number of ventricular and/or atrial pre-systoles occurring in the plurality of cardiac cycles may be identified according to the electrocardiograph signal, a first comparison result of the number of ventricular and/or atrial pre-systoles and a preset first number threshold may be obtained, and whether the degree of abnormality of the physiological signal exceeds the preset degree may be determined according to the first comparison result, that is, if the number of ventricular and/or atrial pre-systoles occurring in the plurality of cardiac cycles is excessive, it may be determined that the degree of abnormality of the physiological signal in the plurality of cardiac cycles exceeds the preset degree, or else, it may be determined that the degree of abnormality of the physiological signal in the plurality of cardiac cycles does not exceed the preset degree.

In addition, the number of continuous irregular cardiac cycles in the plurality of cardiac cycles can be identified according to the electrocardiosignals, a second comparison result of the number of continuous irregular cardiac cycles and a preset second number threshold is obtained, whether the abnormality degree of the physiological signals exceeds the preset degree or not is determined according to the second comparison result, that is, if the number of continuous irregular cardiac cycles in the plurality of cardiac cycles reaches a certain value, the abnormality degree of the physiological signals in the plurality of cardiac cycles exceeds the preset degree, otherwise, the abnormality degree of the physiological signals in the plurality of cardiac cycles does not exceed the preset degree can be determined.

Referring to fig. 10, only a small number of cardiac cycles of the cardiac signal are abnormal, so the degree of abnormality does not exceed the preset degree, and in fig. 11 and 12, it can be seen that the number of irregular cardiac cycles is large, so the degree of abnormality exceeds the preset degree.

Step S800, correcting pulse signals of a plurality of cardiac cycles according to the physiological signals, and calculating cardiovascular parameters according to the corrected pulse signals.

When there is no abnormality in the physiological signal in the plurality of cardiac cycles, since the physiological signal is completely trusted, the pulse signal can be corrected in the following manner:

(1) removing pulse signals corresponding to irregular cardiac cycles from the pulse signals of a plurality of cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals. As described above, when the physiological signals in the plurality of cardiac cycles are abnormal, the pulse signals corresponding to the irregular cardiac cycles in the plurality of cardiac cycles are abnormal, so that the abnormal pulse signals can be removed, and then the cardiovascular parameters can be obtained according to the pulse signals in the regular cardiac cycles in the plurality of cardiac cycles.

(2) In the calculation of the cardiovascular parameters, some intermediate parameters are usually obtained first, for example, in the above, when calculating the pulse pressure variation rate PPV, the difference between the systolic pressure and the diastolic pressure is obtained first to obtain the pulse pressure difference PP. When the physiological signal is not abnormal, the physiological signal can be used for replacing the pulse signal to obtain some intermediate parameters, for example, when the physiological signal is an electrocardio signal, and when some intermediate parameters including a heart rate are calculated, the heart rate calculated by the electrocardio signal can be used for replacing the heart rate calculated by the pulse signal to obtain the heart rate.

When there is abnormality in the physiological signals in the plurality of cardiac cycles, but the abnormality is less than the preset level, the correction method includes: removing pulse signals corresponding to abnormal physiological signals from the pulse signals of a plurality of cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals. Note that, in this embodiment, the pulse signal corresponding to the abnormal physiological signal is removed in units of cardiac cycles, that is, if there is an abnormality in the physiological signal of one cardiac cycle, the pulse signal corresponding to the whole cardiac cycle is removed from the pulse signals of a plurality of cardiac cycles, so as to obtain a corrected pulse signal.

Step S900, calculating a cardiovascular parameter using pulse signals outside of a plurality of cardiac cycles.

That is, when the pulse signal is abnormal and the physiological signal is normal, the pulse signal may be corrected as in (1) or (2), or the acquired physiological signals of a plurality of cardiac cycles may be discarded directly, and the cardiovascular parameter may be calculated using the pulse signals other than the plurality of cardiac cycles. If the physiological signal is abnormal and the abnormality is serious, it can be judged that the pulse signals of a plurality of cardiac cycles cannot be corrected to be "remedied", so that the pulse signals of a plurality of cardiac cycles can be used for calculating the cardiovascular parameter. In some embodiments, when other pulse signals are used to obtain cardiovascular parameters, a prompt may also be output: due to the influence of arrhythmia, the currently calculated cardiovascular parameters are used with caution.

In some embodiments, calculating the cardiovascular parameter using pulse signals outside of the plurality of cardiac cycles includes: the cardiovascular parameters obtained before the cardiac cycles are directly used as the cardiovascular parameters of the cardiac cycles, for example, in the process of monitoring a patient, irregular cardiac cycles do not exist in the first to nth cardiac cycles, primary cardiovascular parameters are obtained through calculation according to pulse signals of the first to nth cardiac cycles, and the abnormal degree of physiological signals in the nth to nth+mth cardiac cycles exceeds a preset degree, so that the cardiovascular parameters of the first to nth cardiac cycles are used as the cardiovascular parameters of the nth to nth+mth cardiac cycles.

In summary, when irregular cardiac cycles do not exist in the multiple cardiac cycles, cardiovascular parameters can be directly obtained through calculation according to pulse signals of the multiple cardiac cycles; when there are irregular cardiac cycles, the following cases can be classified: (1) If the pulse signals in the plurality of cardiac cycles are abnormal, the cardiovascular parameters can be obtained by using other pulse signals, and the pulse signals can be corrected when the physiological signals are not abnormal or the degree of the abnormality is smaller than a preset degree. (2) If there is no abnormality in the pulse signal in a plurality of cardiac cycles, the pulse signal is corrected when the degree of abnormality in the physiological signal is small, and when the degree of abnormality in the physiological signal is large, the cardiovascular parameter is obtained using other pulse signals.

In the above embodiment, by acquiring the physiological signal homologous to the pulse signal, when there is an irregular cardiac cycle, the pulse signal may be corrected to improve the accuracy of calculating the cardiovascular parameter, or other pulse signals may be used to calculate the cardiovascular parameter, so as to avoid using inaccurate cardiovascular parameters.

Reference is made to various exemplary embodiments herein. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope herein. For example, the various operational steps and components used to perform the operational steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or combined into other steps) depending on the particular application or taking into account any number of cost functions associated with the operation of the system.

Additionally, as will be appreciated by one of skill in the art, the principles herein may be reflected in a computer program product on a computer readable storage medium preloaded with computer readable program code. Any tangible, non-transitory computer readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, blu-Ray disks, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means which implement the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.

While the principles herein have been shown in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components, which are particularly adapted to specific environments and operative requirements, may be used without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.

The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the present disclosure is to be considered as illustrative and not restrictive in character, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. The benefits, advantages, solutions to problems, and any element(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as a critical, required, or essential feature. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "couple" and any other variants thereof are used herein to refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections, and/or any other connection.

Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention. Accordingly, the scope of the invention should be determined from the following claims.

Claims (23)

1. A medical device, comprising:

a pulse sensor for acquiring pulse signals of a plurality of cardiac cycles of a patient;

a physiological parameter sensor for acquiring physiological signals of a plurality of said cardiac cycles reflecting the heart beat of the patient, of at least one other path homologous to said pulse signal;

the processor is used for synchronously comparing the pulse signals with the physiological signals, determining the pulse signals and the physiological signals belonging to the same cardiac cycle, and determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the pulse signals and/or the physiological signals respectively corresponding to the cardiac cycles, wherein the physiological signals and/or the pulse signals in the irregular cardiac cycles are abnormal;

when irregular cardiac cycles exist in a plurality of cardiac cycles, correcting pulse signals of the cardiac cycles according to abnormal conditions of the physiological signals, and calculating cardiovascular parameters according to the corrected pulse signals; alternatively, the cardiovascular parameter is calculated using pulse signals outside of the plurality of cardiac cycles.

2. The medical device of claim 1, wherein said synchronizing the pulse signal and the physiological signal to determine the pulse signal and the physiological signal attributed to the same cardiac cycle comprises:

identifying a first instant of occurrence of each of the cardiac cycles in the pulse signal;

identifying a second instant of occurrence of each of the cardiac cycles in the physiological signal;

determining the first time and the second time corresponding to the same cardiac cycle, wherein the time difference between the first time and the second time corresponding to the same cardiac cycle is within a preset range;

and determining the pulse signal and the physiological signal in the same cardiac cycle corresponding to the first time and the second time of the same cardiac cycle as the pulse signal and the physiological signal belonging to the same cardiac cycle.

3. The medical device of claim 2, wherein said identifying a first instant of occurrence of each of said cardiac cycles in said pulse signal comprises:

extracting an occurring P wave crest from the pulse signal;

and taking the moment of occurrence of each P wave crest as the first moment of occurrence of each cardiac cycle.

4. The medical device of claim 2, wherein said identifying a second instant of occurrence of each of said cardiac cycles in said physiological signal comprises:

extracting an emerging R-wave peak from the physiological signal;

and taking the moment of occurrence of each R wave crest as the second moment of occurrence of each cardiac cycle.

5. The medical device of claim 2, wherein said determining whether an irregular cardiac cycle exists among a plurality of said cardiac cycles based on said pulse signal and/or said physiological signal respectively corresponding to each of said cardiac cycles comprises:

extracting cardiac cycle information of each cardiac cycle according to the pulse signals corresponding to each cardiac cycle, wherein the cardiac cycle information is used for representing the characteristics of the cardiac cycle;

and obtaining comparison results of the cardiac cycle information of each cardiac cycle and the cardiac cycle information of the set control cardiac cycle, and determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the comparison results.

6. The medical device of claim 5, wherein the cardiac cycle information includes at least one of a magnitude, an interval, and a QRS wave width of a cardiac cycle.

7. The medical device of claim 2 or 5, wherein said determining whether an irregular cardiac cycle exists among a plurality of said cardiac cycles based on said pulse signal and/or said physiological signal respectively corresponding to each of said cardiac cycles comprises:

and acquiring a heart beat classification result and an arrhythmia recognition result corresponding to each cardiac cycle according to the physiological signals corresponding to each cardiac cycle, and determining whether irregular cardiac cycles exist in the cardiac cycles according to the heart beat classification result and the arrhythmia recognition result corresponding to each cardiac cycle.

8. The medical device of claim 1, wherein the abnormal condition of the physiological signal includes the presence and degree of abnormality, wherein the modifying the pulse signal of the plurality of cardiac cycles based on the abnormal condition of the physiological signal, and wherein calculating the cardiovascular parameter based on the modified pulse signal, comprises:

when the physiological signals in the cardiac cycles are abnormal, or when the physiological signals in the cardiac cycles are abnormal and the degree of the abnormality is smaller than a preset degree, the pulse signals in the cardiac cycles are corrected according to the physiological signals, and cardiovascular parameters are calculated according to the corrected pulse signals.

9. The medical device of claim 1, wherein the abnormal condition of the physiological signal includes the presence and extent of abnormality, and wherein the calculating a cardiovascular parameter using pulse signals outside of the plurality of cardiac cycles based on the abnormal condition of the physiological signal includes:

and when the physiological signals in the plurality of cardiac cycles are abnormal, or when the physiological signals in the plurality of cardiac cycles are abnormal and the degree of the abnormality is larger than a preset degree, calculating cardiovascular parameters by using pulse signals outside the plurality of cardiac cycles.

10. The medical device of claim 8, wherein when there is no abnormality in the physiological signal in the plurality of cardiac cycles, correcting pulse signals of the plurality of cardiac cycles based on the physiological signal, and calculating a cardiovascular parameter based on the corrected pulse signals, comprises:

removing pulse signals corresponding to the irregular cardiac cycles from the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals; or alternatively

And replacing the corresponding pulse signals with the physiological signals corresponding to the irregular cardiac cycles in the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

11. The medical device of claim 8, wherein when there is an abnormality in the physiological signals in the plurality of cardiac cycles and the degree of abnormality is less than a preset degree, correcting pulse signals of the plurality of cardiac cycles based on the physiological signals, and calculating a cardiovascular parameter based on the corrected pulse signals, comprising:

removing pulse signals corresponding to abnormal physiological signals from the pulse signals of the plurality of cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

12. A method of calculating a cardiovascular parameter, comprising:

acquiring pulse signals of a plurality of cardiac cycles of a patient;

acquiring physiological signals of a plurality of cardiac cycles of which at least one other path homologous to the pulse signals is used for reflecting heart beats of a patient;

synchronizing the pulse signal and the physiological signal, and determining the pulse signal and the physiological signal belonging to the same cardiac cycle;

determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the pulse signals and/or the physiological signals respectively corresponding to the cardiac cycles, wherein the physiological signals and/or the pulse signals in the irregular cardiac cycles are abnormal;

When irregular cardiac cycles exist in a plurality of cardiac cycles, correcting pulse signals of the cardiac cycles according to abnormal conditions of the physiological signals, and calculating cardiovascular parameters according to the corrected pulse signals; alternatively, the cardiovascular parameter is calculated using pulse signals outside of the plurality of cardiac cycles.

13. The method of claim 12, wherein said synchronizing the pulse signal and the physiological signal to determine the pulse signal and the physiological signal attributed to the same cardiac cycle comprises:

identifying a first instant of occurrence of each of the cardiac cycles in the pulse signal;

identifying a second instant of occurrence of each of the cardiac cycles in the physiological signal;

determining the first time and the second time corresponding to the same cardiac cycle, wherein the time difference between the first time and the second time corresponding to the same cardiac cycle is within a preset range;

and determining the pulse signal and the physiological signal in the same cardiac cycle corresponding to the first time and the second time of the same cardiac cycle as the pulse signal and the physiological signal belonging to the same cardiac cycle.

14. The method of claim 13, wherein said identifying a first instant of occurrence of each of said cardiac cycles in said pulse signal comprises:

extracting an occurring P wave crest from the pulse signal;

and taking the moment of occurrence of each P wave crest as the first moment of occurrence of each cardiac cycle.

15. The method of claim 13, wherein said identifying a second instant of occurrence of each of said cardiac cycles in said physiological signal comprises:

extracting an emerging R-wave peak from the physiological signal;

and taking the moment of occurrence of each R wave crest as the second moment of occurrence of each cardiac cycle.

16. The method of claim 13, wherein said determining whether an irregular cardiac cycle exists among a plurality of said cardiac cycles based on said pulse signal and/or said physiological signal respectively corresponding to each of said cardiac cycles comprises:

extracting cardiac cycle information of each cardiac cycle according to the pulse signals corresponding to each cardiac cycle, wherein the cardiac cycle information is used for representing the characteristics of the cardiac cycle;

and obtaining comparison results of the cardiac cycle information of each cardiac cycle and the cardiac cycle information of the set control cardiac cycle, and determining whether irregular cardiac cycles exist in a plurality of cardiac cycles according to the comparison results.

17. The method of claim 16, wherein the cardiac cycle information includes at least one of amplitude, interval, and QRS wave width of the cardiac cycle.

18. The method according to claim 13 or 16, wherein said determining whether an irregular cardiac cycle exists among a plurality of said cardiac cycles from said pulse signal and/or said physiological signal respectively corresponding to each of said cardiac cycles comprises:

and acquiring a heart beat classification result and an arrhythmia recognition result corresponding to each cardiac cycle according to the physiological signals corresponding to each cardiac cycle, and determining whether irregular cardiac cycles exist in the cardiac cycles according to the heart beat classification result and the arrhythmia recognition result corresponding to each cardiac cycle.

19. The method of claim 12, wherein the abnormal condition of the physiological signal includes the presence and degree of abnormality, and wherein the modifying the pulse signals of the plurality of cardiac cycles based on the abnormal condition of the physiological signal, and calculating the cardiovascular parameter based on the modified pulse signals, comprises:

when the physiological signals in the cardiac cycles are abnormal, or when the physiological signals in the cardiac cycles are abnormal and the degree of the abnormality is smaller than a preset degree, the pulse signals in the cardiac cycles are corrected according to the physiological signals, and cardiovascular parameters are calculated according to the corrected pulse signals.

20. The method of claim 12, wherein the abnormal condition of the physiological signal includes the presence and extent of abnormality, and wherein the calculating a cardiovascular parameter using pulse signals outside of the plurality of cardiac cycles based on the abnormal condition of the physiological signal includes:

and when the physiological signals in the plurality of cardiac cycles are abnormal, or when the physiological signals in the plurality of cardiac cycles are abnormal and the degree of the abnormality is larger than a preset degree, calculating cardiovascular parameters by using pulse signals outside the plurality of cardiac cycles.

21. The method of claim 19, wherein when there is no abnormality in the physiological signal in the plurality of cardiac cycles, correcting the pulse signal in the plurality of cardiac cycles based on the physiological signal, and calculating a cardiovascular parameter based on the corrected pulse signal, comprises:

removing pulse signals corresponding to the irregular cardiac cycles from the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals; or alternatively

And replacing the corresponding pulse signals with the physiological signals corresponding to the irregular cardiac cycles in the pulse signals of the multiple cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

22. The method of claim 19, wherein when there is an abnormality in the physiological signal in the plurality of cardiac cycles and the degree of abnormality is less than a preset degree, correcting the pulse signals of the plurality of cardiac cycles based on the physiological signal, and calculating a cardiovascular parameter based on the corrected pulse signals, comprising:

removing pulse signals corresponding to abnormal physiological signals from the pulse signals of the plurality of cardiac cycles to obtain corrected pulse signals, and calculating cardiovascular parameters according to the corrected pulse signals.

23. A computer readable storage medium having stored thereon a program executable by a processor to implement the method of any of claims 12 to 22.