CN117642161A - 与阿扎胞苷联合用于治疗骨髓增生异常综合征的维奈托克给药方案 - Google Patents

与阿扎胞苷联合用于治疗骨髓增生异常综合征的维奈托克给药方案 Download PDF

Info

Publication number
CN117642161A
CN117642161A CN202280048997.0A CN202280048997A CN117642161A CN 117642161 A CN117642161 A CN 117642161A CN 202280048997 A CN202280048997 A CN 202280048997A CN 117642161 A CN117642161 A CN 117642161A
Authority
CN
China
Prior art keywords
count
baseline
human subject
equal
white blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN202280048997.0A
Other languages
English (en)
Chinese (zh)
Inventor
J·海斯利普
S·H·凯
W·B·安斯沃斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of CN117642161A publication Critical patent/CN117642161A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202280048997.0A 2021-05-11 2022-05-10 与阿扎胞苷联合用于治疗骨髓增生异常综合征的维奈托克给药方案 Withdrawn CN117642161A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163201749P 2021-05-11 2021-05-11
US63/201749 2021-05-11
PCT/US2022/028429 WO2022240786A1 (en) 2021-05-11 2022-05-10 Venetoclax dosing regimens for use in treating myelodysplastic syndromes in combination with azacitidine

Publications (1)

Publication Number Publication Date
CN117642161A true CN117642161A (zh) 2024-03-01

Family

ID=84028499

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280048997.0A Withdrawn CN117642161A (zh) 2021-05-11 2022-05-10 与阿扎胞苷联合用于治疗骨髓增生异常综合征的维奈托克给药方案

Country Status (11)

Country Link
US (1) US20220378811A1 (enExample)
EP (1) EP4337183A4 (enExample)
JP (1) JP2024517318A (enExample)
KR (1) KR20240006659A (enExample)
CN (1) CN117642161A (enExample)
AU (1) AU2022273023A1 (enExample)
BR (1) BR112023023677A2 (enExample)
CA (1) CA3219760A1 (enExample)
IL (1) IL308321A (enExample)
MX (1) MX2023013364A (enExample)
WO (1) WO2022240786A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3258941A4 (en) * 2015-02-17 2018-09-26 Cantex Pharmaceuticals, Inc. Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction
JP7585231B2 (ja) * 2019-04-29 2024-11-18 イミュノジェン, インコーポレイテッド 抗cd123免疫複合体を含む治療的組み合わせ
WO2020257671A1 (en) * 2019-06-20 2020-12-24 Celgene Corporation Azacitidine in combination with venetoclax, gilteritinib, midostaurin or other compounds for treating leukemia or myelodysplastic syndrome
WO2021037933A1 (en) * 2019-08-28 2021-03-04 Astrazeneca Ab Combination of azd2811 nanoparticles, 5-azacitidine and venetoclax for use in the treatment of cancer
PH12022550835A1 (en) * 2019-10-18 2023-07-03 Forty Seven Inc Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia

Also Published As

Publication number Publication date
IL308321A (en) 2024-01-01
CA3219760A1 (en) 2022-11-17
JP2024517318A (ja) 2024-04-19
AU2022273023A1 (en) 2023-11-23
US20220378811A1 (en) 2022-12-01
BR112023023677A2 (pt) 2024-02-20
KR20240006659A (ko) 2024-01-15
EP4337183A1 (en) 2024-03-20
WO2022240786A1 (en) 2022-11-17
MX2023013364A (es) 2023-11-27
EP4337183A4 (en) 2025-04-23

Similar Documents

Publication Publication Date Title
JP6726252B2 (ja) 骨髄抑制の処置
Choy et al. Therapeutic benefit of blocking interleukin‐6 activity with an anti–interleukin‐6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double‐blind, placebo‐controlled, dose‐escalation trial
CN108883109A (zh) 用于治疗急性髓性白血病的联合疗法
Robak et al. Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma
CN117651556A (zh) 与cyp3a抑制剂和阿扎胞苷联合治疗骨髓增生异常综合征的维奈托克给药方案
Zhang et al. Therapeutic potential of low‐dose IL‐2 in immune thrombocytopenia: an analysis of 3 cases
Hansen‐Abeck et al. Pegylated interferon‐α2a in cutaneous T‐cell lymphoma–a multicenter retrospective data analysis with 70 patients
TWI899057B (zh) 接受造血幹細胞移植的患者之血液惡性腫瘤的復發抑制劑
US20220378811A1 (en) Venetoclax dosing regimens for use in treating myelodysplastic syndromes in combination with azacitidine
WO2021037933A1 (en) Combination of azd2811 nanoparticles, 5-azacitidine and venetoclax for use in the treatment of cancer
Dallorso et al. Clinical benefits of granulocyte colony-stimulating factor therapy after hematopoietic stem cell transplant in children: results of a prospective randomized trial
Göçer et al. Safety and efficacy analysis of ibrutinib in 32 patients with CLL and various B-cell lymphomas: real-world data from a single-center study in Turkey
HK40106739A (en) Venetoclax dosing regimens for use in treating myelodysplastic syndromes in combination with azacitidine
HK40106881A (en) Venetoclax dosing regimens for use in treating myelodysplastic syndromes in combination with a cyp3a inhibitor and azacitidine
Chang et al. Rituximab and CHOP chemotherapy plus GM-CSF for previously untreated diffuse large B-cell lymphoma in the elderly: a Wisconsin oncology network study
WO2023234933A1 (en) Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies in elderly patients
Lundin et al. Phase II study of cyclophosphamide, interferon-a and betamethasone (CIB) as induction therapy for patients 6075 years of age with multiple myeloma stages II and III
AU2018201697B2 (en) Treatment of myelosuppression
WO2025014827A1 (en) Pralatrexate and cop combination for the treatment of patients with peripheral t cell lymphoma
Göçer et al. BLOOD RESEARCH
WO2025122961A1 (en) Methods for treating neutropenia
WO2024211523A1 (en) Dosing regimens for use in preventing relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation with venetoclax in combination with azacitidine
List Management of myelodysplastic syndromes
بسام فرنسيس متي et al. Efficacy and Tolerance of Fludarabine and Cyclophosphamide (FC) Combination Regimen in Advance Stage of Chronic Lymphocytic Leukemia
Stathopoulos et al. Metastatic renal cancer and patient survival as a criterion of treatment response

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40106739

Country of ref document: HK

WW01 Invention patent application withdrawn after publication

Application publication date: 20240301

WW01 Invention patent application withdrawn after publication