CN117635511A

CN117635511A - Medical image processing method, medical image processing device, computer equipment and storage medium

Info

Publication number: CN117635511A
Application number: CN202210985277.9A
Authority: CN
Inventors: 胡凌志; 谷亚梦; 孙熙杉; 李玉生
Original assignee: Shanghai United Imaging Healthcare Co Ltd
Current assignee: Shanghai United Imaging Healthcare Co Ltd
Priority date: 2022-08-17
Filing date: 2022-08-17
Publication date: 2024-03-01

Abstract

The present application relates to a medical image processing method, apparatus, computer device, storage medium and computer program product. The method comprises the following steps: acquiring an MR image and a PET image corresponding to a target area of a target object; the target object wears a brain function headgear in the target area; adjusting the first attenuation template image according to the MR image to obtain a second attenuation template image; the first attenuation template image is used for representing attenuation values corresponding to all components in the brain function headgear when the PET/CT system is used for scanning a scanning die body with the brain function headgear; and carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image. By adopting the method, the positions of each component of the brain function headgear in the PET image can be accurately attenuated and corrected, the accurate corrected PET image is obtained, and the attenuation and correction accuracy of the PET image is improved.

Description

Medical image processing method, medical image processing device, computer equipment and storage medium

Technical Field

The present application relates to the field of image processing technology, and in particular, to a medical image processing method, apparatus, computer device, storage medium, and computer program product.

Background

In recent years, along with the continuous development of medical technology, the development of multi-mode imaging technology is more and more mature. Common multi-mode imaging techniques are PET/MR (PET (Positron Emission Tomography, positron emission computed tomography); MR (Magnetic Resonance, nuclear magnetic resonance)) imaging techniques.

For more accurate medical diagnosis and treatment, brain function imaging techniques may be combined with PET/MR imaging techniques. However, brain function headgear can produce attenuation to PET photons in PET/MR imaging techniques that is difficult to correct, resulting in low accuracy of attenuation correction for PET images during brain function imaging and PET/MR imaging combination.

Therefore, the problem of low accuracy of PET image attenuation correction exists in the prior art.

Disclosure of Invention

In view of the foregoing, it is desirable to provide a medical image processing method, apparatus, computer device, computer readable storage medium, and computer program product that can improve the accuracy of PET image attenuation correction.

In a first aspect, the present application provides a medical image processing method. The method comprises the following steps:

acquiring an MR image and a PET image corresponding to a target area of a target object; the target object wears a brain function headgear in the target area;

Adjusting the first attenuation template image according to the MR image to obtain a second attenuation template image; the first attenuation template image is used for representing attenuation values corresponding to components in the brain function headgear when a PET/CT system is adopted to scan a scanning die body wearing the brain function headgear;

and carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image.

In one embodiment, the adjusting the first attenuation template image according to the MR image to obtain a second attenuation template image includes:

taking the MR image as a reference image and the first attenuation template image as a floating image;

non-rigid registration is carried out on the reference image and the floating image, and a registered floating image is obtained;

and fusing the registered floating image with the MR image to obtain the second attenuation template image.

In one embodiment, the performing non-rigid registration on the reference image and the floating image to obtain a registered floating image includes:

determining a spatial position mapping relationship between the reference image and the floating image;

Mapping the floating image into the reference image according to the spatial position mapping relation to obtain the registered floating image; the registered floating image is the same as the spatial position of the corresponding point in the reference image.

In one embodiment, the performing attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image includes:

determining the spatial position of each component in the brain function headgear in the second attenuation template image;

determining corresponding target space positions of the components in the PET image according to the space position mapping relation between the MR image and the PET image;

and according to the second attenuation template image, carrying out attenuation compensation on an image area where the target space position is located in the PET image to obtain the corrected PET image.

In one embodiment, the method further comprises:

acquiring an initial phantom CT image and an initial phantom PET image; the initial phantom CT image and the initial phantom PET image are obtained by adopting the PET/CT system to scan a scanning phantom wearing the brain function headgear;

Determining initial attenuation coefficients corresponding to all components in the brain function headgear according to the initial phantom CT image;

adjusting the initial attenuation coefficient to obtain an adjusted attenuation image;

and carrying out attenuation correction on the initial die body PET image according to the adjusted attenuation image, and taking the adjusted attenuation image as the first attenuation template image if the difference between average target uptake values corresponding to all preset image areas in the initial die body PET image after attenuation correction meets a preset difference condition.

In one embodiment, the adjusting the initial attenuation coefficient to obtain an adjusted attenuation image includes:

adjusting the initial attenuation coefficient to obtain an adjusted attenuation coefficient;

converting the adjusted attenuation coefficient into an adjusted attenuation value corresponding to each component in the brain function headgear;

and generating the adjusted attenuation image according to the adjusted attenuation values corresponding to the components in the brain function headgear.

In a second aspect, the present application also provides a medical image processing apparatus. The device comprises:

the acquisition module is used for acquiring an MR image and a PET image corresponding to a target area of a target object; the target object wears a brain function headgear in the target area;

The adjustment module is used for adjusting the first attenuation template image according to the MR image to obtain a second attenuation template image; the first attenuation template image is used for representing attenuation values corresponding to components in the brain function headgear when a PET/CT system is adopted to scan a scanning die body wearing the brain function headgear;

and the correction module is used for carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image.

In a third aspect, the present application also provides a computer device. The computer device comprises a memory storing a computer program and a processor which when executing the computer program performs the steps of:

In a fourth aspect, the present application also provides a computer-readable storage medium. The computer readable storage medium having stored thereon a computer program which when executed by a processor performs the steps of:

In a fifth aspect, the present application also provides a computer program product. The computer program product comprises a computer program which, when executed by a processor, implements the steps of:

The medical image processing method, apparatus, computer device, storage medium and computer program product described above, by acquiring MR images and PET images corresponding to a target region of a target object; wherein, the target object wears a brain function headgear in the target area; adjusting the first attenuation template image according to the MR image to obtain a second attenuation template image; the first attenuation template image is used for representing attenuation values corresponding to all components in the brain function headgear when the PET/CT system is used for scanning a scanning die body with the brain function headgear; carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image; thus, due to the characteristics of flexibility, flexibility and the like of the brain function headgear, PET photons can be attenuated in the PET/MR imaging technology, and attenuation values corresponding to all components in the brain function headgear are difficult to clearly determine through MR images corresponding to target areas of a target object in which the brain function headgear is worn; the attenuation values corresponding to the components in the brain function headgear can be accurately determined through a first attenuation template image obtained by scanning a scanning die body with the brain function headgear by using a PET/CT system; the first attenuation template image is adjusted through the MR image capable of clearly displaying the positions of all the components in the brain function headgear, attenuation values corresponding to the positions of all the components in the brain function headgear in the PET image obtained according to the PET/MR imaging technology can be determined, and a second attenuation template image is obtained; and further, the positions of all components of the brain function headgear in the PET image can be accurately attenuated and corrected according to the second attenuation template image, so that an accurate corrected PET image is obtained, and the attenuation and correction accuracy of the PET image is improved.

Drawings

FIG. 1 is a flow chart of a medical image processing method in one embodiment;

FIG. 2 is a schematic diagram of a brain function headgear using non-UTE sequence scanning in one embodiment;

FIG. 3 is a schematic diagram of a brain function headgear using UTE sequence scanning in one embodiment;

FIG. 4 is a schematic diagram of a second attenuation template image in one embodiment;

FIG. 5 is a phantom PET image corresponding to a scan phantom when a PET/CT system is employed in one embodiment;

FIG. 6 is an initial phantom PET image in one embodiment;

FIG. 7 is a schematic view of a scan phantom and brain function headgear corresponding to a PET/CT system in one embodiment;

FIG. 8 (a) is another initial phantom PET image in one embodiment;

FIG. 8 (b) is a cross-axis view, a coronal view, and a sagittal view, respectively, of a first attenuation template image in one embodiment;

FIG. 8 (c) is a uniform reconstructed phantom PET image in one embodiment;

FIG. 9 is a flow chart of a medical image processing method according to another embodiment;

FIG. 10 is a block diagram of a medical image processing apparatus in one embodiment;

FIG. 11 is an internal block diagram of a computer device in one embodiment.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.

In one embodiment, as shown in fig. 1, a medical image processing method is provided for use with a computer device. In practical applications, the computer device may be a user terminal, or may be implemented by a server stand alone or a server cluster formed by a plurality of servers. The user terminal may be, but is not limited to, various personal computers, notebook computers, smart phones, tablet computers, and portable wearable devices.

In this embodiment, the method includes the steps of:

in step S110, an MR image and a PET image corresponding to a target region of a target object are acquired.

Wherein the target subject wears a brain function headgear in the target region.

Wherein, the brain function headgear is a medical headgear for brain function imaging.

Wherein the brain function headgear may be, but is not limited to, an infrared imaging headgear.

Wherein the MR image and the PET image are images acquired by the PET/MR integrated device for scanning a target area of a target object.

In a specific implementation, the PET/MR integrated device can scan a target area of a target object, which is worn with a brain function headgear, and acquire an MR image and a PET image corresponding to the target area of the target object, so that the computer device can acquire paired MR images and PET images acquired by the PET/MR integrated device.

Step S120, the first attenuation template image is adjusted according to the MR image, and a second attenuation template image is obtained.

Wherein the first attenuation template image is determined from a CT image obtained by scanning a scanning phantom wearing a brain function headgear by a PET/CT (Computed Tomography, electronic computer tomography) system.

The first attenuation template image is used for representing attenuation values corresponding to components in the brain function headgear when the PET/CT system is used for scanning a scanning die body with the brain function headgear. Wherein the attenuation value is a PET attenuation value.

Wherein, each component in the brain function headgear is a probe, a cable and the like in the brain function headgear.

Wherein, the PET/CT system can be a PET/CT integrated device.

In specific implementation, a PET/CT system can be adopted to scan a scanning die body wearing a brain function headgear, a computer device can obtain a CT image corresponding to the scanning die body and a PET image corresponding to the scanning die body according to a scanning result, the computer device can determine initial attenuation coefficients corresponding to all components in the brain function headgear under the PET function according to the CT image, and an attenuation image adopted when the reconstructed PET image corresponding to the scanning die body is uniform is determined by adjusting the initial attenuation coefficients, so that a first attenuation template image is obtained. And the first attenuation template image can represent PET attenuation values corresponding to each component in the brain function headgear when the PET/CT system is used for scanning the scanning die body wearing the brain function headgear.

Among them, in order to ensure the stability, accuracy, etc. of imaging of medical imaging apparatuses such as MR apparatuses, CT apparatuses, PET/CT integrated apparatuses, PET/MR integrated apparatuses, etc., it is generally necessary to detect and correct certain parameters of the imaging apparatuses using a scanning phantom before shipment or at the time of routine maintenance. Therefore, after the scanning die body wearing the brain function headgear is scanned through the PET/CT system, the obtained first attenuation template image can accurately represent attenuation values corresponding to all components in the brain function headgear.

Then, the computer device may adjust the first attenuation template image according to the MR image, and fuse the adjusted first attenuation template image with the MR image to obtain a second attenuation template image.

And step S130, carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image.

In a specific implementation, the computer device can determine the PET attenuation value corresponding to each component position of the brain function headgear in the PET image according to the second attenuation template image, so that the PET image can be subjected to attenuation correction by using the second attenuation template image, and the corrected PET image is obtained.

In this way, after the attenuation correction is performed on the PET image, the PET/MR scan and the brain function scan can be simultaneously started on the target region of the target subject, on which the brain function headgear is worn.

In the medical image processing method, an MR image and a PET image corresponding to a target area of a target object are acquired; wherein, the target object wears a brain function headgear in the target area; adjusting the first attenuation template image according to the MR image to obtain a second attenuation template image; the first attenuation template image is used for representing attenuation values corresponding to all components in the brain function headgear when the PET/CT system is used for scanning a scanning die body with the brain function headgear; carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image; thus, due to the characteristics of flexibility, flexibility and the like of the brain function headgear, PET photons can be attenuated in the PET/MR imaging technology, and attenuation values corresponding to all components in the brain function headgear are difficult to clearly determine through MR images corresponding to target areas of a target object in which the brain function headgear is worn; the attenuation values corresponding to the components in the brain function headgear can be accurately determined through a first attenuation template image obtained by scanning a scanning die body with the brain function headgear by using a PET/CT system; the first attenuation template image is adjusted through the MR image capable of clearly displaying the positions of all the components in the brain function headgear, attenuation values corresponding to the positions of all the components in the brain function headgear in the PET image obtained according to the PET/MR imaging technology can be determined, and a second attenuation template image is obtained; and further, the positions of all components of the brain function headgear in the PET image can be accurately attenuated and corrected according to the second attenuation template image, so that an accurate corrected PET image is obtained, and the attenuation and correction accuracy of the PET image is improved.

In one embodiment, adjusting the first attenuation template image based on the MR image to obtain a second attenuation template image includes: taking the MR image as a reference image and taking the first attenuation template image as a floating image; non-rigid registration is carried out on the reference image and the floating image, and a registered floating image is obtained; and fusing the registered floating image with the MR image to obtain a second attenuation template image.

The MR image is obtained by scanning a target area by using a UTE sequence (magnetic resonance ultra-short echo time sequence) through a PET/MR integrated device.

When a PET/MR integrated device is used for scanning a target area of a target object wearing a brain function headgear, if a UTE sequence is used for scanning, the brain function headgear can be imaged under the UTE sequence, so that the accurate position of the brain function headgear can be accurately detected, and the finally obtained MR image can accurately and clearly display the positions of all components in the brain function headgear. If the target area wearing the brain function headgear is scanned using a conventional magnetic resonance sequence, the brain function headgear cannot be imaged under the conventional magnetic resonance sequence.

For ease of understanding by those skilled in the art, fig. 2 provides a schematic illustration of a brain functional headgear when scanning using a non-UTE sequence, i.e., a conventional magnetic resonance sequence. As shown in fig. 2, the brain function headgear cannot be imaged. For ease of understanding by those skilled in the art, fig. 3 provides a schematic illustration of a brain function headgear when scanned using UTE sequences. As shown in fig. 3, the brain function headset may be imaged so that the position of the probe and cable in the brain function headset may be detected.

In a specific implementation, in the process that the computer equipment adjusts the first attenuation template image according to the MR image to obtain the second attenuation template image, the computer equipment can take the MR image as a reference image, namely a fixed image, and take the first attenuation template image as a floating image; the computer device may then perform a non-rigid registration of the MR image as the reference image with the first attenuation template image as the floating image to obtain a registered floating image, i.e. a registered first attenuation template image; the registered floating image is spatially aligned with the MR image; and then fusing the registered floating images, namely the registered first attenuation template images, with the MR images, and taking the fused images as second attenuation template images.

For ease of understanding by those skilled in the art, fig. 4 provides a schematic illustration of a second attenuation template image obtained by fusing the MR images with the registered first attenuation template image. As shown in fig. 4, the positions of the components in the brain function headgear can be clearly displayed in the second attenuation template image; meanwhile, the numerical value corresponding to each pixel in the second attenuation template image is a PET attenuation value, so that the second attenuation template image can represent the PET attenuation value corresponding to each component in the brain function headgear.

According to the technical scheme, an MR image is used as a reference image, and a first attenuation template image is used as a floating image; non-rigid registration is carried out on the reference image and the floating image, and a registered floating image is obtained; fusing the registered floating image with the MR image to obtain a second attenuation template image; thus, the MR image can accurately and clearly display the positions of all components in the brain function headgear, and the first attenuation template image can determine the attenuation values corresponding to all the components in the brain function headgear; by carrying out non-rigid registration on the MR image and the first attenuation template image, the registered first attenuation template image can be aligned with the MR image, so that a second attenuation template image obtained by fusing the registered first attenuation template image and the MR image not only can accurately display the positions of all components in the brain function headgear but also can represent attenuation values corresponding to all the components in the brain function headgear, thereby accurately correcting attenuation caused by the brain function headgear in the PET image by utilizing the second attenuation template image and effectively improving the attenuation correction accuracy of the PET image.

In one embodiment, non-rigid registration is performed on a reference image and a floating image to obtain a registered floating image, including: determining a spatial position mapping relation between the reference image and the floating image; and mapping the floating image into the reference image according to the spatial position mapping relation to obtain a registered floating image.

Wherein the registered floating image and the corresponding point in the reference image have the same spatial position.

In the specific implementation, in the process that the computer equipment carries out non-rigid registration on the reference image and the floating image to obtain a registered floating image, the computer equipment can determine the spatial mapping relation between the MR image serving as the reference image and the first attenuation template image serving as the floating image, map the first attenuation template image serving as the floating image into the MR image serving as the reference image according to the spatial mapping relation, so that the first attenuation template image corresponds to points corresponding to the same position in space in the MR image one by one to obtain the registered floating image, namely the registered first attenuation template image; thus, the registered first attenuation template image is identical to the spatial position of the corresponding point in the MR image as the reference image.

According to the technical scheme, the spatial position mapping relation between the reference image and the floating image is determined; mapping the floating image into a reference image according to the spatial position mapping relation to obtain a registered floating image; the registered floating image and the corresponding point in the reference image have the same spatial position; therefore, the registered first attenuation template image and the registered first attenuation template image are accurately aligned, the MR image and the registered first attenuation template image can be accurately fused, the fused second attenuation template image can accurately display the positions of all components in the brain function headgear, and attenuation values corresponding to all the components in the brain function headgear can be accurately represented.

In one embodiment, performing attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image, including: determining the spatial position of each component in the brain function headgear in the second attenuation template image; determining the corresponding target space position of the space position of each component in the PET image according to the space position mapping relation between the MR image and the PET image; and according to the second attenuation template image, carrying out attenuation compensation on the image area where the target space position is located in the PET image, and obtaining a corrected PET image.

In a specific implementation, the computer device may determine a spatial position mapping relationship between an MR image obtained by scanning a target region of the target object with the PET/MR integrated device and the PET image. The computer equipment performs attenuation correction on the PET image according to the second attenuation template image, and in the process of obtaining the corrected PET image, the computer equipment can determine the spatial position of each component in the brain function headgear in the second attenuation template image; then, the computer equipment can determine the corresponding position of the spatial position of each component in the PET image as the corresponding target spatial position of each component in the PET image according to the spatial position mapping relation between the MR image and the PET image; finally, the computer device may perform attenuation compensation on the image area where the target spatial position corresponding to each component is located in the PET image according to the attenuation value corresponding to each component in the second attenuation template image, so as to obtain a corrected PET image.

In practical application, after the computer equipment acquires the paired MR images and PET images, the MR images serving as reference images and the PET images serving as floating images can be registered to obtain registered PET images, so that the registered PET images and the MR images are aligned in spatial positions; then, since the second attenuation template image is obtained by fusing the registered first attenuation template, which is spatially aligned with the MR image, the second attenuation template image is spatially aligned with the registered PET image. In the process of carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image, the computer equipment can directly carry out attenuation compensation on the image area where the spatial positions of all components in the registered PET image are located through attenuation values corresponding to all components in the second attenuation template image to obtain the corrected PET image.

According to the technical scheme, the spatial positions of all components in the brain function headgear are determined in the second attenuation template image; determining the corresponding target space position of the space position of each component in the PET image according to the space position mapping relation between the MR image and the PET image; according to the second attenuation template image, carrying out attenuation compensation on an image area where the target space position is located in the PET image to obtain a corrected PET image; therefore, the attenuation values corresponding to the components in the brain function headgear are accurately assigned in the PET image according to the second attenuation template image, the attenuation of the brain function headgear to the PET image can be accurately corrected, and the attenuation correction accuracy of the PET image is improved.

In one embodiment, the method further comprises: acquiring an initial phantom CT image and an initial phantom PET image; determining initial attenuation coefficients corresponding to all components in the brain function headgear according to the initial phantom CT image; adjusting the initial attenuation coefficient to obtain an adjusted attenuation image; and carrying out attenuation correction on the initial die body PET image according to the adjusted attenuation image, and taking the adjusted attenuation image as a first attenuation template image if the difference between average target uptake values corresponding to all preset image areas in the initial die body PET image after the attenuation correction meets a preset difference condition.

The initial phantom CT image and the initial phantom PET image are obtained by scanning a scanning phantom wearing a brain function headgear by adopting a PET/CT system.

Wherein, the PET/CT system can be a PET/CT integrated device.

The initial phantom CT image is an image obtained by scanning a scanning phantom wearing a brain function headgear by adopting a CT function in a PET/CT system.

The average target uptake value corresponding to each preset image area is an average value of the target uptake values corresponding to each pixel in each preset image area.

The target intake value may be a weight corrected SUV (standard uptake value, standard intake value). Among them, the weight corrected SUV may be named as a weight uptake value (SUV bw).

The initial die body PET image after attenuation correction can be named as a reconstructed die body PET image in practical application.

Wherein the adjusted attenuation image may represent adjusted attenuation values corresponding to each component in the brain function headgear.

The difference between the average target uptake values corresponding to the preset image areas may be a difference between the average target uptake values.

The preset difference condition may be that a difference between average target intake values is smaller than a preset difference threshold.

In specific implementation, the PET/CT system can scan a scanning die body wearing a brain function headgear to obtain an initial die body CT image and an initial die body PET image corresponding to the scanning die body for the computer equipment to acquire. Wherein, the PET photons are attenuated by each component in the brain function headgear, so that the uptake value of the initial phantom PET image is uneven.

For ease of understanding by those skilled in the art, FIG. 5 provides a method of using a PET/CT system for a non-worn brainAnd scanning the scanning die body of the functional headgear to obtain a die body PET image corresponding to the scanning die body. Wherein Pixels characterizes the number of Pixels; area characterizes the Area of a preset image Area in mm ² (square millimeters); mean represents the average target uptake value corresponding to the preset image area; max represents the maximum value in the target uptake values corresponding to each pixel in the preset image area; min represents the minimum value in the target uptake values corresponding to the pixels in the preset image area; SD characterizes standard deviations in target uptake values corresponding to pixels in a preset image region. The average target uptake values corresponding to the preset image areas in the die body PET image are 107.69, 109.41, 111.86, 109.08, 110.97, 111.20 and 108.12. It can be seen that the difference between the average target uptake values corresponding to the respective preset image areas in the phantom PET image is small.

For ease of understanding by those skilled in the art, FIG. 6 provides a schematic representation of an initial phantom PET image. As shown in fig. 6, the average target uptake values corresponding to the respective preset image areas are "107.46", "88.49", "94.92", "94.80", "103.47", "103.10" and "101.52". It can be seen that the difference between the average target uptake values corresponding to the preset image areas in the initial phantom PET image is large due to attenuation of the PET photons by the components in the brain functional headgear.

For ease of understanding by those skilled in the art, fig. 7 provides a schematic image of a scan phantom corresponding to a brain functional headgear under a PET/CT system. Wherein 710 is a scan phantom; 720 is brain function headgear.

When the PET/CT system is used for scanning the scanning die body, a rod source (rod source) is used as a radiation source, and the rod source is used for transmission scanning or quality control testing of positron emitter layer imaging.

After the computer equipment acquires the initial die body CT image and the initial die body PET image, the initial die body CT image can represent CT values corresponding to all components in the brain function headgear, and the computer equipment can determine attenuation coefficients matched with the CT values corresponding to all the components in the brain function headgear according to the mapping relation between the CT values and the attenuation coefficients under the gamma ray energy level corresponding to the PET function, so as to obtain initial attenuation coefficients (namely initial MU values) corresponding to all the components in the brain function headgear; then, the computer equipment can adjust initial attenuation coefficients corresponding to all components in the brain function headgear, namely, corresponding attenuation coefficients (MU values) are newly endowed to all the components in the brain function headgear, and an adjusted attenuation image is obtained according to the adjusted attenuation coefficients corresponding to all the components in the brain function headgear, wherein the adjusted attenuation image can represent adjusted PET attenuation values corresponding to all the components in the brain function headgear; and then, the computer equipment can carry out attenuation correction on the initial die body PET image according to the adjusted attenuation image, namely, the initial die body PET image is subjected to attenuation correction according to the adjusted attenuation values corresponding to the components in the brain function headgear, so that the initial die body PET image after attenuation correction is obtained.

The computer equipment can determine average target uptake values corresponding to all preset image areas in the initial die body PET image after attenuation correction so as to determine differences among the average target uptake values corresponding to all the preset image areas; if the difference between average target uptake values corresponding to the preset image areas meets a preset difference condition, determining the initial die body PET image after attenuation correction as a uniform reconstructed die body PET image, and taking the adjusted attenuation image as a first attenuation template image.

The computer equipment can also generate an initial attenuation image according to the initial attenuation coefficient after acquiring the initial attenuation coefficient corresponding to each component in the brain function headgear, carry out attenuation correction on the initial phantom PET image according to the initial attenuation image, and if the difference between average target uptake values corresponding to preset image areas in the initial phantom PET image after the attenuation correction meets a preset difference condition, take the initial attenuation image as a first attenuation template image. And if the difference between the average target uptake values corresponding to the preset image areas does not meet the preset difference condition, executing the step of adjusting the initial attenuation coefficient to obtain an adjusted attenuation image until the difference between the average target uptake values corresponding to the preset image areas in the initial die body PET image after attenuation correction meets the preset difference condition.

Therefore, when the uniform reconstructed die body PET image is obtained according to the first attenuation template image, the PET attenuation values corresponding to the components in the brain function headgear are determined, and the PET attenuation values corresponding to the components in the brain function headgear are accurately assigned, so that the PET image acquired through the PET/MR system can be subjected to attenuation correction according to the PET attenuation values corresponding to the components in the brain function headgear, and the uniform corrected PET image is obtained.

For ease of understanding by those skilled in the art, fig. 8 (a) -8 (c) provide a schematic illustration of attenuation correction of an initial phantom PET image by a first attenuation template image.

Fig. 8 (a) shows another initial phantom PET image, and as shown in fig. 8 (a), average target uptake values corresponding to each preset image area in the initial phantom PET image are "115.18", "117.72", "140.88", "150.94", "150.64" and "108.15". It can be seen that the difference between the average target uptake values corresponding to the preset image areas in the initial phantom PET image is large.

Fig. 8 (b) provides a transverse axis view, a coronal view, and a sagittal view corresponding to the first attenuation template image, respectively.

Wherein fig. 8 (c) provides a uniform reconstructed phantom PET image. As shown in fig. 8 (c), average target uptake values corresponding to the respective preset image areas in the uniform reconstructed phantom PET image are "44.93", "43.97", "49.68", "44.86" and "50.09". It can be seen that the difference between the average target uptake values corresponding to the preset image areas in the image is small.

According to the technical scheme, an initial die body CT image and an initial die body PET image are acquired; the initial die body CT image and the initial die body PET image are obtained by adopting a PET/CT system to scan a scanning die body with a brain function headgear; determining initial attenuation coefficients corresponding to all components in the brain function headgear according to the initial phantom CT image; adjusting the initial attenuation coefficient to obtain an adjusted attenuation image; performing attenuation correction on the initial die body PET image according to the adjusted attenuation image, and taking the adjusted attenuation image as a first attenuation template image if the difference between average target uptake values corresponding to all preset image areas in the initial die body PET image after the attenuation correction meets a preset difference condition; in this way, when the difference between average target uptake values corresponding to each preset image area in the initial die body PET image after attenuation correction meets the preset difference condition, the initial die body PET image after attenuation correction can be used as a uniform reconstructed die body PET image, so that an adjusted attenuation image corresponding to the uniform reconstructed die body PET image can be used as a first attenuation template image, and the attenuation information of each component in the brain function headgear can be accurately determined and obtained when the uniform reconstructed die body PET image is obtained; furthermore, the PET image corresponding to the target region of the target object can be accurately attenuated and corrected according to the attenuation information.

In one embodiment, adjusting the initial attenuation coefficient to obtain an adjusted attenuation image includes: adjusting the initial attenuation coefficient to obtain an adjusted attenuation coefficient; converting the adjusted attenuation coefficient into adjusted attenuation values corresponding to the components in the brain function headgear; and generating an adjusted attenuation image according to the adjusted attenuation values corresponding to the components in the brain function headgear.

In the specific implementation, in the process of adjusting the initial attenuation coefficient to obtain an adjusted attenuation image, the computer equipment can adjust the initial attenuation coefficient corresponding to each component in the brain function headgear to obtain an adjusted attenuation coefficient corresponding to each component in the brain function headgear, so as to obtain two-dimensional distribution (adjusted attenuation coefficient matrix) of the adjusted attenuation coefficient corresponding to each component; then, the computer equipment can convert the adjusted attenuation coefficient corresponding to each component in the brain function headgear into an adjusted attenuation value corresponding to each component in the brain function headgear according to a calculation formula of the attenuation value, so as to obtain two-dimensional distribution (adjusted attenuation value matrix) of the adjusted attenuation value; finally, the computer device may generate an adjusted attenuation image from the two-dimensional distribution of adjusted attenuation values.

According to the technical scheme, the initial attenuation coefficient is adjusted to obtain an adjusted attenuation coefficient; converting the adjusted attenuation coefficient into adjusted attenuation values corresponding to the components in the brain function headgear; generating an adjusted attenuation image according to the adjusted attenuation values corresponding to the components in the brain function headgear; so that the adjusted attenuation image can represent the adjusted attenuation value corresponding to each component in the brain function headgear; when the adjusted attenuation image can be used as a first attenuation template image, the first attenuation template image can accurately represent attenuation values corresponding to all components in the brain functional headgear when the uniform reconstructed phantom PET image is obtained, so that the first attenuation template image can be used for carrying out high-accuracy attenuation correction on the PET image corresponding to the target area of the target object.

In another embodiment, as shown in fig. 9, there is provided a medical image processing method, which is exemplified as the application of the method to a computer device, including the steps of:

step S910, acquiring an initial phantom CT image and an initial phantom PET image; the initial phantom CT image and the initial phantom PET image are obtained by scanning a scanning phantom wearing a brain function headgear by adopting a PET/CT system.

Step S920, determining initial attenuation coefficients corresponding to all components in the brain function headgear according to the initial phantom CT image.

In step S930, the initial attenuation coefficient is adjusted to obtain an adjusted attenuation image.

Step S940, carrying out attenuation correction on the initial die body PET image according to the adjusted attenuation image, and taking the adjusted attenuation image as a first attenuation template image if the difference between average target uptake values corresponding to all preset image areas in the initial die body PET image after the attenuation correction meets a preset difference condition.

In step S950, an MR image and a PET image corresponding to the target region of the target object are acquired.

Step S960, taking the MR image as a reference image and taking the first attenuation template image as a floating image.

In step S970, non-rigid registration is performed on the reference image and the floating image, so as to obtain a registered floating image.

Step S980, fusing the registered floating image with the MR image, to obtain a second attenuation template image.

Step S990, carrying out attenuation correction on the PET image according to the second attenuation template image to obtain a corrected PET image.

It should be noted that, for specific limitation of the above steps, reference may be made to the above specific limitation of a medical image processing method.

It should be understood that, although the steps in the flowcharts related to the embodiments described above are sequentially shown as indicated by arrows, these steps are not necessarily sequentially performed in the order indicated by the arrows. The steps are not strictly limited to the order of execution unless explicitly recited herein, and the steps may be executed in other orders. Moreover, at least some of the steps in the flowcharts described in the above embodiments may include a plurality of steps or a plurality of stages, which are not necessarily performed at the same time, but may be performed at different times, and the order of the steps or stages is not necessarily performed sequentially, but may be performed alternately or alternately with at least some of the other steps or stages.

Based on the same inventive concept, the embodiments of the present application also provide a medical image processing apparatus for implementing the above-mentioned related medical image processing method. The implementation of the solution provided by the device is similar to the implementation described in the above method, so the specific limitation of one or more embodiments of the medical image processing device provided below may be referred to above as limitation of a medical image processing method, and will not be repeated here.

In one embodiment, as shown in fig. 10, there is provided a medical image processing apparatus including: an acquisition module 1010, an adjustment module 1020, and a correction module 1030, wherein:

an acquiring module 1010, configured to acquire an MR image and a PET image corresponding to a target region of a target object; the target subject wears a brain function headgear at the target region.

An adjustment module 1020, configured to adjust the first attenuation template image according to the MR image, to obtain a second attenuation template image; the first attenuation template image is used for representing attenuation values corresponding to components in the brain function headgear when a PET/CT system is used for scanning a scanning die body wearing the brain function headgear.

And the correction module 1030 is configured to perform attenuation correction on the PET image according to the second attenuation template image, so as to obtain a corrected PET image.

In one embodiment, the adjusting module 1020 is specifically configured to take the MR image as a reference image and the first attenuation template image as a floating image; non-rigid registration is carried out on the reference image and the floating image, and a registered floating image is obtained; and fusing the registered floating image with the MR image to obtain the second attenuation template image.

In one embodiment, the adjusting module 1020 is specifically configured to determine a spatial position mapping relationship between the reference image and the floating image; mapping the floating image into the reference image according to the spatial position mapping relation to obtain the registered floating image; the registered floating image is the same as the spatial position of the corresponding point in the reference image.

In one embodiment, the correction module 1030 is specifically configured to determine, in the second attenuation template image, a spatial location of each component in the brain function headgear; determining corresponding target space positions of the components in the PET image according to the space position mapping relation between the MR image and the PET image; and according to the second attenuation template image, carrying out attenuation compensation on an image area where the target space position is located in the PET image to obtain the corrected PET image.

In one embodiment, the apparatus further comprises: the die body image acquisition module is used for acquiring an initial die body CT image and an initial die body PET image; the initial phantom CT image and the initial phantom PET image are obtained by adopting the PET/CT system to scan a scanning phantom wearing the brain function headgear; the coefficient determining module is used for determining initial attenuation coefficients corresponding to all components in the brain function headgear according to the initial phantom CT image; the coefficient adjustment module is used for adjusting the initial attenuation coefficient to obtain an adjusted attenuation image; and the template image determining module is used for carrying out attenuation correction on the initial die body PET image according to the adjusted attenuation image, and taking the adjusted attenuation image as the first attenuation template image if the difference between average target uptake values corresponding to all preset image areas in the initial die body PET image after the attenuation correction meets a preset difference condition.

In one embodiment, the coefficient adjustment module is specifically configured to adjust the initial attenuation coefficient to obtain an adjusted attenuation coefficient; converting the adjusted attenuation coefficient into an adjusted attenuation value corresponding to each component in the brain function headgear; and generating the adjusted attenuation image according to the adjusted attenuation values corresponding to the components in the brain function headgear.

Each of the modules in the above-described one medical image processing apparatus may be implemented in whole or in part by software, hardware, and combinations thereof. The above modules may be embedded in hardware or may be independent of a processor in the computer device, or may be stored in software in a memory in the computer device, so that the processor may call and execute operations corresponding to the above modules.

In one embodiment, a computer device is provided, which may be a terminal, and the internal structure thereof may be as shown in fig. 11. The computer device includes a processor, a memory, a communication interface, a display screen, and an input device connected by a system bus. Wherein the processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage media. The communication interface of the computer device is used for carrying out wired or wireless communication with an external terminal, and the wireless mode can be realized through WIFI, a mobile cellular network, NFC (near field communication) or other technologies. The computer program is executed by a processor to implement a medical image processing method. The display screen of the computer equipment can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer equipment can be a touch layer covered on the display screen, can also be keys, a track ball or a touch pad arranged on the shell of the computer equipment, and can also be an external keyboard, a touch pad or a mouse and the like.

It will be appreciated by those skilled in the art that the structure shown in fig. 11 is merely a block diagram of a portion of the structure associated with the present application and is not limiting of the computer device to which the present application applies, and that a particular computer device may include more or fewer components than shown, or may combine some of the components, or have a different arrangement of components.

In an embodiment, there is also provided a computer device comprising a memory and a processor, the memory having stored therein a computer program, the processor implementing the steps of the method embodiments described above when the computer program is executed.

In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored which, when executed by a processor, carries out the steps of the method embodiments described above.

In an embodiment, a computer program product is provided, comprising a computer program which, when executed by a processor, implements the steps of the method embodiments described above.

It should be noted that, user information (including but not limited to user equipment information, user personal information, etc.) and data (including but not limited to data for analysis, stored data, presented data, etc.) referred to in the present application are information and data authorized by the user or sufficiently authorized by each party.

Those skilled in the art will appreciate that implementing all or part of the above described methods may be accomplished by way of a computer program stored on a non-transitory computer readable storage medium, which when executed, may comprise the steps of the embodiments of the methods described above. Any reference to memory, database, or other medium used in the various embodiments provided herein may include at least one of non-volatile and volatile memory. The nonvolatile Memory may include Read-Only Memory (ROM), magnetic tape, floppy disk, flash Memory, optical Memory, high density embedded nonvolatile Memory, resistive random access Memory (ReRAM), magnetic random access Memory (Magnetoresistive Random Access Memory, MRAM), ferroelectric Memory (Ferroelectric Random Access Memory, FRAM), phase change Memory (Phase Change Memory, PCM), graphene Memory, and the like. Volatile memory can include random access memory (Random Access Memory, RAM) or external cache memory, and the like. By way of illustration, and not limitation, RAM can be in the form of a variety of forms, such as static random access memory (Static Random Access Memory, SRAM) or dynamic random access memory (Dynamic Random Access Memory, DRAM), and the like. The databases referred to in the various embodiments provided herein may include at least one of relational databases and non-relational databases. The non-relational database may include, but is not limited to, a blockchain-based distributed database, and the like. The processors referred to in the embodiments provided herein may be general purpose processors, central processing units, graphics processors, digital signal processors, programmable logic units, quantum computing-based data processing logic units, etc., without being limited thereto.

The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples only represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the present application. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application shall be subject to the appended claims.

Claims

1. A medical image processing method, the method comprising:

2. The method of claim 1, wherein adjusting the first attenuation template image based on the MR image results in a second attenuation template image, comprising:

3. The method of claim 2, wherein non-rigid body registration of the reference image and the floating image results in a registered floating image, comprising:

and mapping the floating image into the reference image according to the spatial position mapping relation to obtain the registered floating image.

4. The method of claim 2, wherein performing attenuation correction on the PET image based on the second attenuation template image to obtain a corrected PET image, comprising:

5. The method according to claim 1, wherein the method further comprises:

and carrying out attenuation correction on the initial die body PET image according to the adjusted attenuation image to obtain the first attenuation template image.

6. The method of claim 5, wherein said adjusting the initial attenuation coefficient results in an adjusted attenuation image, comprising:

7. A medical image processing apparatus, the apparatus comprising:

8. A computer device comprising a memory and a processor, the memory storing a computer program, characterized in that the processor implements the steps of the method of any of claims 1 to 6 when the computer program is executed.

9. A computer readable storage medium, on which a computer program is stored, characterized in that the computer program, when being executed by a processor, implements the steps of the method of any of claims 1 to 6.

10. A computer program product comprising a computer program, characterized in that the computer program, when being executed by a processor, implements the steps of the method of any of claims 1 to 6.