CN117618163B

CN117618163B - Cartilage prosthesis

Info

Publication number: CN117618163B
Application number: CN202410091478.3A
Authority: CN
Inventors: 魏瑄; 骆晓飞; 王金良; 丁波; 张帅; 王亚松
Original assignee: Beijing AK Medical Co Ltd; Zhengzhou Orthopedics Hospital
Current assignee: Beijing AK Medical Co Ltd; Zhengzhou Orthopedics Hospital
Priority date: 2024-01-23
Filing date: 2024-01-23
Publication date: 2024-04-09
Anticipated expiration: 2044-01-23
Also published as: CN117618163A

Abstract

The present invention provides a cartilage prosthesis comprising: the shell is provided with a plurality of tooth grooves on the outer surface, a base is arranged at the bottom of the shell, a hollow cylinder is arranged on the base, and a first external thread and a first internal thread are respectively arranged on the outer surface and the inner surface of the hollow cylinder; the top of the rotating device is provided with a curved surface which is attached to the joint surface, the edge of the curved surface of the rotating device is provided with a clamping groove, the bottom of the rotating device is provided with a rotating cylinder, and the rotating cylinder is connected to the hollow cylinder; the top edge of the sleeve is provided with a hemispherical groove, and the sleeve is sleeved outside the rotating cylinder of the rotating device; one end of the elastic rack is fixed on the base, the other end of the elastic rack is fixed on the sleeve, and a plurality of elastic racks are inserted into the tooth grooves; the bottom surface outward flange of gasket is provided with the buckle, and the buckle can with aforesaid draw-in groove closure. The technical scheme of the application effectively solves the problem of local lesions of the cartilage prosthesis in the related technology.

Description

Cartilage prosthesis

Technical Field

The present invention relates to a prosthesis capable of being transplanted into a body, and in particular to a cartilage prosthesis.

Background

The articular cartilage is a white, semitransparent, tough and smooth connective tissue, is mainly distributed on the surface of the joint, and plays roles of buffering, reducing friction and protecting the joint. The articular cartilage is composed of chondrocyte, collagen fiber, polysaccharide and other components. Together, these components ensure smooth movement and stability of the joint. The main functions include: cushioning, the cartilage absorbs and disperses shocks and vibrations caused by physical activity during joint movement, and serves to relieve stress. The friction is reduced, the surface of the joint cartilage is smooth, the friction between joint bones can be reduced, and the joint can move stably. The cartilage acts as a protective layer for the joint, preventing direct friction and wear of the bone, and thus reducing the risk of joint wear and injury. Providing stability, cartilage helps maintain the structural stability of the joint, preventing abnormal swing or dislocation of the joint bone.

The health of articular cartilage is critical to normal joint function. However, articular cartilage may be damaged or degenerated due to trauma, age, inflammation, etc., resulting in joint problems such as osteoarthritis, etc. Articular cartilage damage can be divided into several types: traumatic articular cartilage injury occurs when the joint is impacted or distorted by external forces, such as sports injuries, accidents, and the like. May cause the cartilage to tear, fray or fall off. Degenerative cartilage damage, as the age increases, the cartilage gradually deteriorates. This type of injury is often associated with arthritis, in which the cartilage gradually loses elasticity and thickness. Cartilage damage caused by overuse, and overuse of a joint by some activities or movements may result in cartilage damage.

Disclosure of Invention

The invention aims to provide a cartilage prosthesis to realize gradient treatment of joint prosthesis and solve the problem of local lesions of the cartilage prosthesis.

In order to solve the above problems, the present invention provides a cartilage prosthesis, comprising: the shell is provided with a plurality of tooth grooves on the outer surface, a base is arranged at the bottom of the shell, a hollow cylinder is arranged on the base, and a first external thread and a first internal thread are respectively arranged on the outer surface and the inner surface of the hollow cylinder; the top of the rotating device is provided with a curved surface which is attached to the joint surface, the edge of the curved surface of the rotating device is provided with a clamping groove, the bottom of the rotating device is provided with a rotating cylinder, and the rotating cylinder is connected to the hollow cylinder; the top edge of the sleeve is provided with a hemispherical groove, and the sleeve is sleeved outside the rotating cylinder of the rotating device; one end of the elastic rack is fixed on the base, the other end of the elastic rack is fixed on the sleeve, and a plurality of elastic racks are inserted into the tooth grooves; the outer edge of the bottom surface of the gasket is provided with a buckle which can be locked with the clamping groove;

further, the curved bottom of the rotating device is provided with a plurality of curved bulges, the rotating cylinder is composed of an inner cylinder and an outer cylinder, wherein the inner surface of the outer cylinder is provided with second external threads, and the outer surface of the inner cylinder is provided with second internal threads.

Further, the threads are of stepped design for more precise rotational adjustment.

Further, the cartilage prosthesis further comprises an elastic component, one end of the elastic component is abutted with the base, and the other end of the elastic component is abutted with the sleeve.

Further, the cartilage and the whole body also comprise a scale ball which is placed in a hemispherical groove on the sleeve.

Further, the relative movement of the scale ball and the curved protrusion corresponds to the approach distance of the rotating cylinder.

Further, capillary tubes are arranged at the bottom of the shell and in the vertical direction of the elastic rack, the average diameter of each capillary tube is 600 microns, and the capillary tubes are formed by tightly arranging polygonal hollow tubes and are used for placing bone morphogenetic proteins.

Further, the capillary structure is made by 3D printing, and the depth of the capillary can be personalized according to individual differences.

Further, the spacer is composed of silk proteins, wherein the concentration of the silk proteins gradually increases from inside to outside, and the artificial joint surface of the spacer is matched with the autogenous bone joint surface.

Further, a matched guide groove is arranged between the sleeve and the rotating cylinder and used for improving the stability of the rotating device.

Further, the elastic rack is made of a bio-ceramic composite material. Wherein the ceramic component provides hardness and wear resistance, while the plasticity and fatigue resistance of the composite material ensures durability and stability of the rack in articulation.

Further, the surface of the cartilage prosthesis, which is in contact with the human bone, is provided with a bioactive coating, which consists of fibroblast growth factor, fibronectin, collagen, anti-inflammatory cytokines and silver ions.

By applying the technical scheme of the invention, the outer surface of the shell is provided with a plurality of tooth grooves, the bottom of the shell is provided with a base, the base is provided with a hollow cylinder, and the outer surface and the inner surface of the hollow cylinder are respectively provided with a first external thread and a first internal thread; the top of the rotating device is provided with a curved surface which is attached to the joint surface, the edge of the curved surface of the rotating device is provided with a clamping groove, the bottom of the rotating device is provided with a rotating cylinder, and the rotating cylinder is connected to the hollow cylinder; the top edge of the sleeve is provided with a hemispherical groove, and the sleeve is sleeved outside the rotating cylinder of the rotating device; one end of each elastic rack is fixed on the base, the other end of each elastic rack is fixed on the sleeve, and a plurality of elastic racks are inserted into the tooth grooves; the outer edge of the bottom surface of the gasket is provided with a buckle which can be locked with the clamping groove. Through the arrangement, the problem of local pathological changes of the joint prosthesis can be effectively solved, the staged, layered and gradient treatment of the prosthesis implantation is realized, after the cartilage prosthesis is implanted into a human body, the barb-shaped structure on the elastic rack can penetrate into the inner wall of the autologous bone to realize good fixing effect, meanwhile, the capillary structures are arranged on the bottom surface of the cartilage prosthesis sleeve and the elastic rack, the structure can be customized according to the personalized difference of a patient, bone morphogenetic protein is injected into the capillary, the bottom of the sleeve is extruded in the process of approaching the rotating cylinder, at the same time, the elastic rack is subjected to micro deformation, the bone morphogenetic protein in the capillary is extruded out of the cartilage prosthesis to be contacted with the autologous bone, and the bone induction effect can be generated structurally better due to the fact that the diameter setting of the capillary is similar to the density of the bone of the human body, so that the bone ingrowth effect of the cartilage prosthesis is improved. The biological coating is arranged on the surface of the cartilage prosthesis, which is contacted with the autologous bone, so that the effects of resisting bacteria, promoting the interaction between cells and the surface, resisting inflammation and the like can be effectively achieved.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention. In the drawings:

FIG. 1 shows a cross-sectional view of a cartilage prosthesis;

FIG. 2 shows an internal structural view of a cartilage prosthesis;

FIG. 3 shows a partial enlarged view at A in FIG. 1;

FIG. 4 shows a partial enlarged view at B in FIG. 1;

FIG. 5 shows a block diagram of a capillary tube;

wherein the above figures include the following reference numerals: 10. a housing; 101. tooth slots; 102. a base; 103. a hollow cylinder; 104. a first external thread; 105. a first internal thread; 20. an elastic rack; 30. an elastic member; 40. a rotating device; 401. rotating the cylinder; 402. a second external thread; 403. a second internal thread, 404, curved protrusion; 405. a clamping groove; 50. a gasket; 501. a buckle; 60. a sleeve; 601. hemispherical grooves; 70. a scale ball; 80. capillary tube.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but should be considered part of the specification where appropriate. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.

As shown in fig. 1-2, a cartilage prosthesis comprising: the shell 10, the outer surface of the shell is provided with a plurality of tooth sockets 101, the bottom of the shell is provided with a base 102, the base is provided with a hollow cylinder 103, and the outer surface and the inner surface of the hollow cylinder are respectively provided with a first external thread 104 and a first internal thread 105; the rotating device 40, the top of the rotating device is set to be a curved surface attached to the joint surface, the edge of the curved surface of the rotating device is provided with a clamping groove 405, the bottom of the rotating device is provided with a rotating cylinder 401, and the rotating cylinder is connected to the hollow cylinder 103; a sleeve 60, the top edge of which is provided with a hemispherical groove 601, the sleeve is sleeved outside the rotating cylinder 401 of the rotating device; and one end of the elastic rack 20 is fixed on the base 102, the other end is fixed on the sleeve 60, a plurality of elastic racks are inserted in the tooth grooves 101, and the elastic racks are made of biological ceramic composite materials. The gasket 50 is provided with a buckle 501 at the outer edge of the bottom surface of the gasket, and the buckle can be locked with the clamping groove 405. The first external thread 104, the first internal thread 105, the second external thread 402 and the second internal thread 403 are all designed in a stepped manner, that is, in the initial stage of thread rotation, the screw pitch is larger, the main purpose is to reduce the number of rotation turns, save the operation time, and in the final stage, the screw pitch is smaller. A matched guide groove is arranged between the sleeve and the rotating cylinder and is used for improving the stability of the rotating device. The cartilage prosthesis further comprises an elastic member 30, one end of which abuts against the base 102 and the other end abuts against the sleeve 60. Its main objective is to increase the feel of rotating the section of thick bamboo when rotating, simultaneously, elastic component also plays the fixed action, prevent unsettled stability that reduces the false body between sleeve and the base, this elastic component is rotating the section of thick bamboo in-process of rotating down, there is an outside elasticity and make the rotation of rotating the section of thick bamboo at the initial stage easier, in the screw in process of last stage, because to realize more accurate regulation, so set up elastic component and can let the doctor have better accuse, elastic component cooperates the stepwise screw thread design above can realize more accurate rotation adjustment.

As shown in fig. 2, the cartilage prosthesis further comprises a spacer 50, wherein the spacer is composed of silk proteins, the concentration of the silk proteins increases gradually from inside to outside, on the one hand, the low concentration of the silk proteins in the inner portion of the spacer can provide good rigidity, so that the locking effect with the clamping groove on the rotating cylinder is better, and on the other hand, the high concentration of the silk proteins in the outer portion of the spacer can provide better fusion effect. In addition, the 3D printing technology can be used for preoperative planning, and artificial joint surfaces with different curvatures are arranged on different affected parts, so that the artificial joint surfaces of the gaskets are matched with the autologous bone joint surfaces. In the use, grind to suitable degree of depth and diameter to disease position earlier, then put into cartilage false body, utilize the rotatory rotary drum of appurtenance, make rotary drum downstream, under the cooperation of sleeve and base, the elasticity rack is crooked, owing to design has the barb structure on the elasticity rack, at the crooked in-process of elasticity rack, the barb can pierce inside the autologous bone, fixes cartilage false body in the autologous bone of grinding in advance.

As shown in fig. 3, the gear engagement mode between the rotating cylinder and the hollow cylinder is an internal and external double-layer thread, the hollow cylinder is provided with a first external thread 104 and a first internal thread 105, the rotating cylinder is provided with a second external thread 402 and a second internal thread 403, the first external thread 104 and the second external thread 402 are engaged with each other, the first internal thread 105 and the second internal thread 403 are engaged with each other, the double-layer thread design improves the stability of the prosthesis and prevents the reverse rotation of the thread, and in the initial stage, the double-layer thread is easier to screw in than the single-layer thread, and the operation difficulty is further reduced.

As shown in fig. 4, the cartilage prosthesis further comprises a scale ball 70 which is placed in a hemispherical recess 601 on the sleeve 60. The relative movement of the scale ball and the curved protrusion 404 corresponds to the advance or close distance of the rotating cylinder 401. The size of the scale ball and the size of the curved bulge can be preset in advance, for example, the diameter of the scale ball is 1mm, the perimeter of one curved bulge is 6mm, the scale ball stops every 6mm, the rotation angle of the current rotating cylinder can be judged through sound, and the bending curvature of the elastic rack can be further determined, so that the elastic rack can be well fixed with the inner surface of the autologous bone. The curved bottom of the rotating device 40 is provided with a plurality of curved protrusions 404, the rotating cylinder 401 is composed of an inner cylinder and an outer cylinder, wherein the inner surface of the outer cylinder is provided with a second external thread 402, and the outer surface of the inner cylinder is provided with a second internal thread 403.

As shown in fig. 5, capillaries 80, each having an average diameter of 600 μm and formed of polygonal hollow tubes closely arranged for the placement of bone morphogenetic proteins, are provided at the bottom of the housing 10 and in the vertical direction of the elastic racks 20. The capillary structure is made by 3D printing, the depth of the capillary can be customized according to individual differences, for example, the cartilage prosthesis is applied to different affected parts, the required bone morphogenetic protein amount can be different, the required bone morphogenetic protein amount of the affected parts is calculated in advance, the 3D printing technology is utilized to manufacture different depths, and in the using process, the bone morphogenetic protein can be transplanted into the capillary by soaking or injecting. After the prosthesis is implanted into a human body, the base generates micro deformation under the action of the longitudinal pressure at the top, so that bone morphogenetic protein in the capillary is extruded, meanwhile, under the action of the rotating cylinder, the rack is deformed, and the bone morphogenetic protein in the internal capillary is extruded, so that the bone induction effect is achieved, and the stability of the prosthesis is improved. Meanwhile, the design of the capillary tube is equivalent to arranging a porous structure, such as a bone trabecular structure, on the surface of the prosthesis, so that the fusion effect of the prosthesis is further improved.

The surface of the cartilage prosthesis in contact with the human bone is provided with a bioactive coating, which can be designed to contain some of the following key components: growth factors: growth factors are protein signaling molecules that play a critical role in cell growth, differentiation and repair. The bioactive coating applied to the cartilage prosthesis may comprise a growth factor such as basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGF- β) to stimulate cell proliferation and cartilage repair in surrounding tissue. Cell adhesion molecule: these molecules help to enhance the adhesion of the prosthesis to surrounding tissue, promoting cell-surface interactions. Typical cell adhesion molecules include fibronectin, collagen, and the like, which provide the support required for cell-directed migration and attachment. Anti-inflammatory substances: in order to reduce the inflammatory response caused by the implant, the bioactive coating may further comprise substances that help to inhibit inflammation, such as anti-inflammatory cytokines or antioxidants. Antibacterial agent: to prevent infection, the bioactive coating may contain an antimicrobial agent, such as silver ions or other antimicrobial agents, to reduce the microbial burden on the implant surface. The precise selection and combination of these components can be tailored to the specific application requirements and individual differences of the patient to achieve optimal biocompatibility, promote cartilage repair, and minimize discomfort associated with the implant.

Optionally, the bone morphogenetic protein and the bioactive coating in the application are used for improving the stability of the prosthesis, so that the surface of the cartilage prosthesis, which is in contact with a human body, can be provided with a capillary structure, the bone morphogenetic protein can be added into the capillary structure, antibacterial medicines and the like can be added into the capillary structure, and the bioactive coating can be arranged on the surfaces of the elastic rack and the bottom of the shell in the same way so as to improve the stability of the prosthesis.

In the description of the present invention, it should be understood that the azimuth or positional relationships indicated by the azimuth terms such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal", and "top, bottom", etc., are generally based on the azimuth or positional relationships shown in the drawings, merely to facilitate description of the present invention and simplify the description, and these azimuth terms do not indicate and imply that the apparatus or elements referred to must have a specific azimuth or be constructed and operated in a specific azimuth, and thus should not be construed as limiting the scope of protection of the present invention; the orientation word "inner and outer" refers to inner and outer relative to the contour of the respective component itself.

Spatially relative terms, such as "above … …," "above … …," "upper surface at … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial location relative to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the exemplary term "above … …" may include both orientations of "above … …" and "below … …". The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

In addition, the terms "first", "second", etc. are used to define the components, and are only for convenience of distinguishing the corresponding components, and the terms have no special meaning unless otherwise stated, and therefore should not be construed as limiting the scope of the present invention.

The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A cartilage prosthesis comprising:

the shell is provided with a plurality of tooth grooves on the outer surface, a base is arranged at the bottom of the shell, a hollow cylinder is arranged on the base, and a first external thread and a first internal thread are respectively arranged on the outer surface and the inner surface of the hollow cylinder;

the top of the rotating device is provided with a curved surface which is attached to the joint surface, the bottom of the curved surface of the rotating device is provided with a plurality of curved bulges, the edge of the curved surface of the rotating device is provided with a clamping groove, the bottom of the rotating device is provided with a rotating cylinder which consists of an inner cylinder and an outer cylinder, wherein the inner surface of the outer cylinder is provided with second external threads, the outer surface of the inner cylinder is provided with second internal threads, the second external threads are meshed with the first external threads, the second internal threads are meshed with the first internal threads, and the rotating cylinder is connected to the hollow cylinder;

the top edge of the sleeve is provided with a hemispherical groove, and the sleeve is sleeved outside the rotating cylinder of the rotating device;

one end of the elastic rack is fixed on the base, the other end of the elastic rack is fixed on the sleeve, and the plurality of elastic racks are inserted into the tooth grooves;

the gasket, the bottom surface outward flange of gasket is provided with the buckle, the buckle is locked with aforementioned draw-in groove.

2. The cartilage prosthesis of claim 1 wherein the threads are of stepped design for more precise rotational adjustment.

3. The cartilage prosthesis of claim 1 further comprising a resilient member having one end abutting the base and the other end abutting the sleeve.

4. The cartilage prosthesis of claim 1 further comprising a scale ball, said scale ball being disposed in a hemispherical recess in said sleeve.

5. The cartilage prosthesis of claim 4 wherein the relative movement of the scale ball and the curved protrusion corresponds to the advancement of the rotating cartridge.

6. The cartilage prosthesis of claim 1, wherein the bottom of the shell and the elastic rack are provided with capillaries in a vertical direction, the average diameter of the capillaries is 600 micrometers, and the capillaries are formed by closely arranging polygonal hollow tubes for placing bone morphogenic proteins.

7. The cartilage prosthesis of claim 6 wherein the capillary structure is made by 3D printing and the depth of the capillaries is personalized to individual differences.

8. The cartilage prosthesis of claim 1 wherein the spacer is comprised of silk proteins wherein the concentration of silk proteins increases progressively from the inside to the outside, the artificial articular surface of the spacer conforming to the autogenous bone articular surface.

9. A cartilage prosthesis according to claim 1, wherein a mating guide slot is provided between the sleeve and the rotating barrel for improving the stability of the rotating device.

10. A cartilage prosthesis in accordance with claim 1, wherein said resilient rack is made of a bio-ceramic composite material.

11. The cartilage prosthesis of claim 1, wherein the cartilage prosthesis is provided with a bioactive coating on the surface contacting the human bone, said bioactive coating being composed of fibroblast growth factor, fibronectin, collagen, anti-inflammatory cytokines, silver ions.