CN117599321A - Percutaneous administration micro-device with anti-drop function and manufacturing method thereof - Google Patents
Percutaneous administration micro-device with anti-drop function and manufacturing method thereof Download PDFInfo
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- CN117599321A CN117599321A CN202311733124.6A CN202311733124A CN117599321A CN 117599321 A CN117599321 A CN 117599321A CN 202311733124 A CN202311733124 A CN 202311733124A CN 117599321 A CN117599321 A CN 117599321A
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- microneedle
- micro
- needle
- silicon wafer
- array
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 32
- 239000010703 silicon Substances 0.000 claims abstract description 32
- 239000000758 substrate Substances 0.000 claims abstract description 24
- 238000013271 transdermal drug delivery Methods 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 239000002195 soluble material Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 238000005530 etching Methods 0.000 claims description 36
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 12
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 12
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 12
- 230000003647 oxidation Effects 0.000 claims description 12
- 238000007254 oxidation reaction Methods 0.000 claims description 12
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 12
- 238000001259 photo etching Methods 0.000 claims description 9
- 230000002093 peripheral effect Effects 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 4
- 238000005266 casting Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 12
- 239000002198 insoluble material Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 14
- 238000012377 drug delivery Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 1
- 206010034912 Phobia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 208000019899 phobic disease Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Abstract
The invention relates to a transdermal drug delivery micro device with an anti-drop function and a manufacturing method thereof, belonging to the technical field of medicines, comprising: the micro needle comprises a silicon wafer substrate, a plurality of micro needle cylinders and a plurality of micro needle heads of soluble materials, wherein the micro needle cylinders are fixed on the top surface of the silicon wafer substrate in an array manner; the bottom surface of the silicon wafer substrate is provided with a plurality of liquid through holes which are respectively communicated with a plurality of micro needle cylinders; the microneedle heads are respectively fixed at the top ends of the microneedle syringes. The invention can be quickly dissolved after the microneedle head made of the sharp soluble material is inserted into the skin, so that the medical risk caused by the breakage of the microneedle head made of the insoluble material left in skin tissues can be avoided; meanwhile, the anti-drop groove is designed, so that the risk that the soluble microneedle head is easy to drop off in the using and storing processes is eliminated, and the reliability is improved; the liquid medicine in the microneedle body is not easy to leak; in addition, a plurality of liquid through holes are respectively communicated with a plurality of micro-needle syringes and a plurality of micro-needle heads, so that continuous administration can be realized.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a percutaneous administration micro-device with an anti-drop function and a manufacturing method thereof.
Background
Currently, in medical practice, the traditional administration mode has unavoidable weaknesses, such as the oral administration mode may have gastrointestinal first pass effect, and the curative effect is reduced; the injection mode can bring pains to patients suffering from needle phobia when in administration. The recent advent of new methods of transdermal delivery using microneedles can potentially eliminate or alleviate the aforementioned weaknesses of traditional delivery methods.
Microneedle forms include solid microneedles, hollow microneedles, and the like. The solid micro needle is inserted into skin to form micro passage in the skin to raise the permeability of the medicine liquid to be transferred and then the medicine liquid is permeated into skin tissue via the patch; or directly wrapping the medicine on the solid microneedle body, and after the medicine is inserted into skin along with the microneedle body, dissolving the medicine into skin tissue to achieve the purpose of administration; the hollow micro needle mode is to directly convey the liquid medicine to the dermis layer of the skin through the inner cavity of the micro needle and enter the human body circulation. While this approach potentially eliminates or reduces the weaknesses of traditional modes of administration, the needles of microneedles employing this approach are very small, often on the sub-micron scale. After insertion of the microneedle tips into skin tissue, there is a possibility of breakage. After the completion of the administration, there is a risk of leaving behind in the skin tissue.
To solve this problem, soluble microneedles have emerged (e.g., J.W.Lee, J.H.Park, M.R.Prausnitz, dissolving microneedles for transdermal drug delivery, biomaterials 29 (2007) 2113-2124 and K.Ita, dissolving Microneedles for Transdermal Drug Delivery: advances and changes. Biomedicine & Pharmacotherapy,2017,93: 1116-1127). The medicine liquid is dissolved on the needle head by the soluble micro needle, and the micro needle head adopts the soluble material. After the administration, the microneedle heads can be dissolved, so that the danger that insoluble materials remain in skin tissues is eliminated. However, since the drug solution is only dissolved in the needle made of a soluble material, the amount of administration in this manner is limited, and there is no possibility of continuous administration. The composite soluble microneedle has the possibility of falling off in the using and storing processes, so that the performance of the microneedle is reduced and even the composite soluble microneedle cannot be used.
Therefore, how to design a transdermal drug delivery microdevice with an anti-drop function is a problem that needs to be solved by those skilled in the art.
Disclosure of Invention
The invention provides a percutaneous administration micro-device with an anti-drop function, which solves the technical problems that a percutaneous administration system cannot continuously administer drugs and insoluble materials are left in skin tissues and are easy to cause danger.
The technical scheme for solving the technical problems is as follows, a transdermal drug delivery micro device with an anti-drop function, comprising: a silicon chip matrix, a plurality of micro needle barrels and a plurality of micro needle heads of soluble materials,
the microneedle syringes are fixed on the top surface of the silicon wafer substrate in an array mode; the bottom surface of the silicon wafer substrate is provided with a plurality of liquid through holes which are respectively communicated with a plurality of micro-needle cylinders; the microneedle heads are respectively fixed at the top ends of the microneedle syringes.
The beneficial effects of the invention are as follows: after the microneedle needle made of the sharp soluble material is inserted into the skin, the microneedle needle is rapidly dissolved (the microneedle needle can be dissolved in about 15 seconds), so that the medical risk caused by the fact that the microneedle needle made of the insoluble material is broken and left in skin tissues can be avoided; meanwhile, as the liquid through holes are respectively communicated with the microneedle syringes and the microneedle needles, continuous drug delivery can be realized, and the use reliability of the percutaneous drug delivery system is improved.
On the basis of the technical scheme, the invention can be improved as follows.
Further, the top ends of a plurality of the micro-needle syringes are all in conical structures.
Further, the outer peripheral side walls of the microneedle syringes close to the top ends of the microneedle syringes are provided with anti-falling grooves.
The anti-drop groove is arranged on the peripheral side wall of the micro needle cylinder close to the top end of the micro needle cylinder, so that the separation of the micro needle head can be avoided, and the use safety of the percutaneous drug delivery system is improved.
In addition, a method for manufacturing a transdermal drug delivery micro device with an anti-drop function is provided, which comprises the following specific steps:
s1, forming a mask layer for etching a microneedle needle cylinder array on the top surface of a silicon wafer substrate after thermal oxidation and photoetching of the silicon wafer substrate;
s2, isotropically etching the top end of the micro needle cylinder to form a conical top end;
s3, anisotropically etching to form an anti-drop groove on the peripheral side wall of the microneedle cylinder close to the top end of the microneedle cylinder;
s4, performing thermal oxidation, forming an oxide layer on the upper part of the anti-falling groove, and then anisotropically etching the oxide layer outside the top mask layer of the microneedle cylinder;
s5, anisotropically etching to form the height required by the anti-drop groove of the microneedle cylinder;
s6, isotropically etching to form a microneedle cylinder anti-drop groove;
s7, anisotropically etching to form a microneedle needle cylinder array;
s8, forming a mask layer for etching the micro needle cylinder array on the bottom surface of the silicon wafer substrate after thermal oxidation and photoetching on the bottom surface of the silicon wafer substrate;
s9, anisotropically etching an inner hole of the micro-needle cylinder array;
s10, removing the mask layer and the oxide layer to form a microneedle needle cylinder array with an anti-drop groove at the upper part;
s11, processing a microneedle head, and forming a mask layer for etching a needle point array of a microneedle head mould on the upper surface of a silicon wafer after thermal oxidation and photoetching of the silicon wafer;
s12, isotropically etching the needle tip of the microneedle mould;
s13, anisotropically etching a needle body in a microneedle head mould;
s14, forming a microneedle head mould for removing the mask layer;
s15, casting PDMS on a microneedle head mould, and then baking;
s16, stripping the PDMS from the microneedle mould to form a PDMS microneedle cavity array master mould;
s17, aligning the microneedle syringe array formed in the S with a PDMS master mould filled with PVP/PVA solution, immersing the conical top end of the microneedle syringe and the anti-drop groove into the PVP/PVA solution, drying to form a soluble microneedle head, and stripping to form the composite microneedle array with the anti-drop soluble microneedle head.
Drawings
FIG. 1 is a schematic illustration of the processing of a silicon wafer substrate and a plurality of microneedle cartridges in a transdermal drug delivery microdevice with anti-slip function according to the present invention;
FIG. 2 is a schematic illustration of the process of manufacturing a microneedle head in a transdermal drug delivery micro-device with anti-release function according to the present invention;
fig. 3 is a schematic view showing the internal structure of a transdermal drug delivery micro device with an anti-drop function according to the present invention.
In the drawings, the list of components represented by the various numbers is as follows:
1. the micro-needle syringe comprises a silicon wafer substrate, 11, a liquid through hole, 2, a micro-needle syringe, 21, an anti-drop groove, 3 and a micro-needle head.
Detailed Description
The principles and features of the present invention are described below with reference to the drawings, the examples are illustrated for the purpose of illustrating the invention and are not to be construed as limiting the scope of the invention.
As shown in fig. 3, a transdermal drug delivery microdevice having an anti-drop function, comprising: a silicon wafer matrix 1, a plurality of microneedle syringes 2 and a plurality of microneedle needles 3 of soluble material,
a plurality of micro needle cylinders 2 are fixed on the top surface of the silicon wafer substrate 1 in an array manner; the bottom surface of the silicon wafer substrate 1 is provided with a plurality of liquid through holes 11 which are respectively communicated with a plurality of micro needle cylinders 2; the microneedle heads 3 are respectively fixed at the top ends of the microneedle syringes 2; after the microneedle made of the sharp soluble material is inserted into the skin, the microneedle can be dissolved in about 15 seconds, so that medical risks caused by the fact that the microneedle made of the insoluble material is broken and left in skin tissues can be avoided; meanwhile, as the liquid through holes are respectively communicated with the microneedle syringes and the microneedle needles, continuous drug delivery can be realized, and the use reliability of the percutaneous drug delivery system is improved.
In some embodiments, the tips of the plurality of microneedle cartridges 2 may each be tapered in configuration.
In some embodiments, the outer circumferential side walls of the microneedle cartridges 2 near the tips thereof may be provided with anti-drop grooves 21.
Specifically, the microneedle cartridge 2 may have an outer diameter of 5 μm to 1000 μm, an inner diameter of 1 μm to 800 μm, and a length of 10 μm to 2000 μm; the length of the microneedle heads 3 may be 10 μm to 1000 μm.
In addition, a method for manufacturing a transdermal drug delivery microdevice having an anti-drop function is provided, comprising the steps of:
s1, forming a mask layer for etching the array of the microneedle cylinder 2 on the top surface of a silicon wafer substrate 1 after thermal oxidation and photoetching of the silicon wafer substrate 1;
s2, (b) forming a conical top end for isotropically etching the top end of the micro-needle cylinder 2;
s3, FIG. 1 (c) is an anisotropic etching, and an anti-falling groove 21 is formed on the peripheral side wall of the microneedle cylinder 2 near the top end of the microneedle cylinder;
s4, performing thermal oxidation to form an oxide layer on the upper part of the anti-falling groove 21, and then anisotropically etching the oxide layer outside the top mask layer of the microneedle cylinder 2, as shown in fig. 1 (d);
s5, then, anisotropically etching to form the height required by the anti-falling groove 21 of the microneedle cylinder 2, as shown in fig. 1 (e);
s6, isotropic etching is carried out to form an anti-falling groove 21 of the microneedle cylinder 2, as shown in fig. 1 (f);
s7, FIG. 1 (g) is an anisotropic deep etching to form a microneedle cylinder 2 array;
s8, in the step (h) of FIG. 1, after thermal oxidation and photoetching are carried out on the bottom surface of the silicon wafer substrate 1, a mask layer for etching the array of the micro-needle cylinder 2 is formed on the bottom surface of the silicon wafer substrate 1;
s9, FIG. 1 (i) shows an inner hole of the array of the anisotropic deep etching micro-needle cylinder 2;
s10, in FIG. 1 (j), a mask layer and an oxide layer are removed to form a microneedle cylinder 2 array with an anti-drop groove 21 on the upper part;
s11, processing the microneedle heads 3, wherein as shown in FIG. 2, FIG. 2 (a) is a silicon wafer, and a mask layer for etching the needle tip array of the microneedle head mould is formed on the upper surface of the silicon wafer after thermal oxidation and photoetching;
s12, FIG. 2 (b) is a diagram showing the isotropic etching of the tip of the microneedle mould;
s13, FIG. 2 (c) is an anisotropically etching needle body in a microneedle mould;
s14, in FIG. 2 (d), removing the mask layer to form a microneedle mould;
s15, in FIG. 2 (e), PDMS is cast on a microneedle mould and then baked;
s16, in the step (f) of FIG. 2, the PDMS is peeled off from the microneedle mould to form a cavity array master mould of the PDMS microneedle 3;
s17, in FIG. 2 (g), the microneedle cylinder 2 array formed by the process shown in FIG. 1 is aligned with a PDMS master mould filled with PVP/PVA solution, the conical top end of the microneedle cylinder 2 and the anti-drop groove 21 are immersed into the PVP/PVA solution, then dried to form a soluble microneedle head 3, and the composite microneedle array with the anti-drop soluble microneedle head is formed after stripping.
The foregoing is only illustrative of the present invention and is not to be construed as limiting thereof, but rather as various modifications, equivalent arrangements, improvements, etc., within the spirit and principles of the present invention.
Claims (5)
1. A transdermal drug delivery microdevice having an anti-drop function, comprising:
a silicon wafer substrate (1),
a plurality of micro needle cylinders (2), wherein the micro needle cylinders (2) are fixed on the top surface of the silicon wafer substrate (1) in an array manner; the bottom surface of the silicon wafer substrate (1) is provided with a plurality of liquid through holes (11) which are respectively communicated with a plurality of micro-needle cylinders (2);
a plurality of microneedle heads (3) of soluble material, wherein the microneedle heads (3) are respectively fixed at the top ends of the microneedle syringes (2).
2. A transdermal drug delivery micro-device with anti-drop function according to claim 1, wherein the tips of a plurality of the micro-needle syringes (2) are all of conical structure.
3. A transdermal drug delivery micro-device with anti-drop function according to claim 1, wherein the outer peripheral side walls of the microneedle syringes (2) near the top ends of the microneedle syringes are provided with anti-drop grooves (21).
4. A transdermal drug delivery micro-device with anti-drop function according to claim 1, characterized in that the microneedle cartridge (2) has an outer diameter of 5 μm-1000 μm, an inner diameter of 1 μm-800 μm and a length of 10 μm-2000 μm; the length of the microneedle heads (3) is 10-1000 mu m.
5. A method for manufacturing a transdermal drug delivery micro device having an anti-drop function, comprising the transdermal drug delivery micro device having an anti-drop function according to any one of claims 1 to 4, comprising the steps of:
s1, forming a mask layer for etching the array of the micro needle cylinder (2) on the top surface of a silicon wafer substrate (1) after thermal oxidation and photoetching of the silicon wafer substrate (1);
s2, isotropically etching the top end of the micro needle cylinder (2) to form a conical top end;
s3, anisotropically etching, wherein an anti-falling groove (21) is formed on the peripheral side wall of the microneedle cylinder (2) close to the top end of the microneedle cylinder;
s4, performing thermal oxidation, namely forming an oxide layer on the upper part of the anti-falling groove (21), and then anisotropically etching the oxide layer outside the top mask layer of the microneedle cylinder (2);
s5, anisotropically etching to form the height required by the anti-falling groove (21) of the microneedle cylinder (2);
s6, isotropically etching to form an anti-falling groove (21) of the microneedle cylinder (2);
s7, anisotropically etching to form a microneedle needle cylinder (2) array;
s8, forming a mask layer for etching the array of the micro needle cylinder (2) on the bottom surface of the silicon wafer substrate (1) after thermal oxidation and photoetching on the bottom surface of the silicon wafer substrate (1);
s9, anisotropically etching an inner hole of the micro-needle cylinder (2) array;
s10, removing the mask layer and the oxide layer to form a microneedle needle cylinder (2) array with an anti-drop groove (21) at the upper part;
s11, processing a microneedle head (3), and forming a mask layer for etching a needle point array of a microneedle head mould on the upper surface of a silicon wafer after thermal oxidation and photoetching of the silicon wafer;
s12, isotropically etching the needle tip of the microneedle mould;
s13, anisotropically etching a needle body in a microneedle head mould;
s14, forming a microneedle head mould for removing the mask layer;
s15, casting PDMS on a microneedle head mould, and then baking;
s16, stripping the PDMS from the microneedle mould to form a PDMS microneedle cavity array master mould;
s17, aligning the microneedle needle cylinder (2) array formed in the S10 to a PDMS master mould filled with PVP/PVA solution, immersing the conical top end of the microneedle needle cylinder (2) and the anti-drop groove (21) into the PVP/PVA solution, drying to form a soluble microneedle needle head (3), and stripping to form the composite microneedle array with the anti-drop soluble needle head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311733124.6A CN117599321A (en) | 2023-12-15 | 2023-12-15 | Percutaneous administration micro-device with anti-drop function and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311733124.6A CN117599321A (en) | 2023-12-15 | 2023-12-15 | Percutaneous administration micro-device with anti-drop function and manufacturing method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN117599321A true CN117599321A (en) | 2024-02-27 |
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|---|---|---|---|
| CN202311733124.6A Pending CN117599321A (en) | 2023-12-15 | 2023-12-15 | Percutaneous administration micro-device with anti-drop function and manufacturing method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN117599321A (en) |
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- 2023-12-15 CN CN202311733124.6A patent/CN117599321A/en active Pending
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