CN117599303A

CN117599303A - Intravascular optical fiber auxiliary treatment device

Info

Publication number: CN117599303A
Application number: CN202311640091.0A
Authority: CN
Inventors: 赵安莎; 王静月; 李君一
Original assignee: Southwest Jiaotong University
Current assignee: Southwest Jiaotong University
Priority date: 2023-11-30
Filing date: 2023-11-30
Publication date: 2024-02-27

Abstract

The invention discloses an intravascular optical fiber auxiliary treatment device, which comprises: the perfusion holes are distributed on the side wall of the outer tube body in a circumferential direction, and at least comprise two shapes, and the perfusion holes in the two shapes are alternately and/or staggered on the outer tube body; the optical fiber guide wire is arranged inside the outer tube body, and a perfusion cavity is formed between the optical fiber guide wire and the outer tube body. The device can evenly spray liquid medicine on the surface of a blood vessel or tissue, promote the sprayed medicine to play a role under the action of laser, improve the spraying effect of the medicine, and effectively solve the problem of poor light source conduction effect of the existing perfusion device.

Description

Intravascular optical fiber auxiliary treatment device

Technical Field

The invention belongs to the technical field of medical appliances, and particularly relates to an intravascular optical fiber auxiliary treatment device.

Background

Minimally invasive interventional procedures are minimally invasive techniques that perform physical, mechanical, or chemical treatment of a lesion by placing a device or drug into the lesion with minimal trauma (no skin incision, only needle eye puncture). The application of the method is deep into a plurality of fields such as ophthalmic diseases, cardiovascular diseases, nervous system and tumor treatment, and the minimally invasive interventional therapy has definite curative effect, small trauma and strong targeting and gradually develops into an important direction in the precise personalized treatment field.

The guide wire and the guide tube are very frequently used in interventional therapy, and can play a role in accurate drug release, radiography positioning, fixed-point thrombus ablation, tumor embolism and other treatment effects in interventional therapy when being matched with the guide wire and the guide tube. The guide wire and the catheter are matched in various aspects of materials and processes, so that more operation modes can be provided for minimally invasive treatment, for example, the effect of mechanical support of a mechanical gripper, a balloon or a bracket can be achieved through the catheter in some special catheters. Light assisted therapy is increasingly used in clinical disease, and new ways of interventional therapy in combination with light are also in the process of progressive development, which puts new demands on catheter and guidewire systems used for interventional therapy. The traditional guide wire mainly considers the compliance, operability, safety, drug release effect and the like of the guide wire, and the effective conductivity of an external light source and the matching property of a catheter are not considered too much, so that when the drug component has certain viscosity, the drug can block the perfusion hole, and the light conductivity is reduced.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides an intravascular optical fiber auxiliary treatment device which can uniformly spray liquid medicines on the surface of a blood vessel or tissue, promote the sprayed medicines to play a role under the action of laser and improve the spraying effect of the medicines, and can effectively solve the problem of poor light source conduction effect of the traditional perfusion device.

In order to achieve the above purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:

an endovascular fiber optic assisted treatment device, comprising:

the perfusion holes are distributed on the side wall of the outer tube body in a circumferential direction, and at least comprise two shapes, and the perfusion holes in the two shapes are alternately and/or staggered on the outer tube body;

the optical fiber guide wire is arranged inside the outer tube body, and a perfusion cavity is formed between the optical fiber guide wire and the outer tube body.

In the scheme, the outer tube body is used as one of the components extending into the blood vessel, is led into a plurality of perfusion holes which are annularly distributed at one end of the blood vessel and are used for uniformly covering the medicament in the perfusion cavity on the inner wall of the blood vessel in a spraying mode, so that the medicament is in a continuous state after falling on the inner wall of the blood vessel, and a uniform medicament layer is formed on the inner wall of the blood vessel; the filling holes are arranged in two shapes, so that the injection device is suitable for injection release of medicines in different states such as liquid state and gel state, and the blocking of the filling holes by the medicines is avoided, and the subsequent optical fiber irradiation effect is prevented from being exerted; under the irradiation of the optical fiber, the medicament layer on the inner wall of the blood vessel plays a role, so that the aim of treatment is fulfilled.

Further, the arrangement mode of the two pouring holes with different shapes on the outer tube body comprises one of longitudinal alternating arrangement, transverse alternating arrangement, longitudinal and transverse alternating arrangement and longitudinal staggered arrangement.

In the scheme, the pouring holes with different shapes are uniformly distributed on the pipe wall of the outer pipe body in a mode of longitudinal alternation, transverse alternation, longitudinal and transverse alternation, longitudinal interlacing and the like, so that the injection effect of the medicament can be fully improved, and the problem of uneven medicament injection caused by blockage of a certain pouring hole is avoided.

Further, the two differently shaped perfusion holes include a circular hole and a bar-shaped hole.

Further, the diameter of the round hole is 80-120um, the length of the strip-shaped hole is 300-400um, the width of the strip-shaped hole is 80-120um, and four corners of the strip-shaped hole are arc-shaped.

Further, the distance between the circular hole and the bar-shaped hole is 150-200um.

Further, the device also comprises a flexible probe, and one end of the outer tube body, which is led into the blood vessel, is arranged in a closed type or an open type;

when one end of the outer tube body leading into the blood vessel is closed, the flexible probe is arranged at the free end of the outer tube body;

when one end of the outer tube body leading-in blood vessel is arranged to be open, the free end of the outer tube body is provided with an end hole, the flexible probe is arranged at the free end of the optical fiber guide wire, and the flexible probe penetrates through the end hole and is arranged outside the outer tube body.

In the scheme, the flexible probe is mainly used as an exploring part for smoothly placing the outer tube body into the affected part of the blood vessel, is of a double-spiral structure, has certain flexibility, can be bent along with the radian of the blood vessel, reduces the damage to the inner wall of the blood vessel, and drives the outer tube body to be smoothly placed into the blood vessel. When the one end of leading-in blood vessel of outer body sets up to closed, flexible probe sets up in outer body free end, flexible probe and outer body are fixed connection, all be provided with the development sign on flexible probe and the outer body, development sign on the outer body sets up in the boundary department of filling the hole, during the use, under external development device's assistance, insert the inside of vessel earlier with flexible probe, drive outer body along the blood vessel constantly deeply through flexible probe, direct affected part, the filling hole of outer body aligns with the affected part in the blood vessel, then pour into the medicament to the filling intracavity through external filling device, and exert certain pressure, make the medicament of filling the intracavity spout with the injection form from the filling hole.

When one end of the outer tube body is led into a blood vessel and is arranged as an open type, the free end of the outer tube body is provided with an end hole, the flexible probe is arranged at the free end of the optical fiber guide wire, the flexible probe penetrates through the end hole and is arranged outside the outer tube body, at the moment, development marks are also arranged at the same positions of the outer tube body and the flexible probe, the flexible probe is fixedly connected with the optical fiber guide wire, and when the optical fiber guide wire is used, the optical fiber guide wire is inserted into the outer tube body by using the current clinically existing guide wire device, penetrates out of the end hole at the front end of the outer tube body, is put into the blood vessel under the traction of the guide wire device, the perfusion hole on the outer tube body is aligned with an affected part in the blood vessel under the auxiliary observation of an external development device, then the guide wire device is pulled out from the outer tube body, the flexible probe is inserted into the outer tube body, and the optical fiber guide wire is placed into the outer tube body under the driving of the flexible probe, so that the smoothness of the optical fiber guide wire is improved when the optical fiber guide wire is put into the outer tube body; after the infusion device is placed, the flexible probe at the front end of the optical fiber guide wire extends out of the end hole of the outer tube body to seal the end hole, at the moment, the external infusion device infuses the medicament into the infusion cavity, and certain pressure is applied, so that the medicament in the infusion cavity is ejected out of the infusion hole in an ejection mode, and the purposes of targeted administration and targeted treatment can be achieved.

Further, when the optical fiber guide wire penetrates through the outer pipe body, a plugging piece is arranged between the optical fiber guide wire and the flexible probe, and the plugging piece is used for plugging the end hole.

In the above-mentioned scheme, the shutoff piece respectively with optic fibre seal wire and flexible probe fixed connection, the diameter of shutoff piece is greater than the diameter of end hole, and its main function is to improving the shutoff effect to the end hole, avoids the medicament to spill over from the end hole under external pressure, and then improves the injection state and the injection effect of medicament.

Further, the flexible probe is arranged in a spiral.

In the scheme, the flexible probe is arranged into a double-spiral structure, has bending property, can smoothly move in the blood vessel or the outer tube body according to radian, reduces mechanical damage to the inner wall of the blood vessel or the outer tube body, and improves the use safety.

Further, the front ends of the flexible probe and the outer tube body are both provided with arc surfaces.

In the scheme, the arc-shaped surface can improve the smoothness of the device, reduce the rigid contact with the inner wall of the blood vessel, further reduce the damage to the inner wall of the blood vessel, improve the efficiency and effect of the implantation of the device and reduce the damage to human bodies.

Further, the optical fiber guide wire comprises a sleeve and optical fiber, wherein the optical fiber is arranged inside the sleeve, a light transmission area is arranged on the sleeve, and the light transmission area is correspondingly arranged with the filling hole.

In the scheme, the sleeve is used for wrapping the optical fiber, at least one optical fiber is arranged, and the optical fiber is used as a light source for treatment and is used for activating or improving the action effect of the medicament; the sleeve is made of transparent materials, a layer of opaque coating is arranged on the inner wall of the sleeve, light emitted by the optical fiber can be shielded, the coating is not arranged at the position, corresponding to the pouring hole, on the sleeve, the light emitted by the optical fiber can act on the medicament on the inner wall of the blood vessel after being irradiated out through the sleeve, and targeted auxiliary treatment is realized. The tail end of the optical fiber guide wire is connected with an external laser source. An annular developing mark is arranged on the sleeve at each interval of 1-2cm and is used for determining the position of the optical fiber guide wire relative to the outer tube body under the assistance of an external developing device.

The beneficial effects of the invention are as follows:

the device can extend into the affected part of the blood vessel in a minimally invasive mode, therapeutic agents are injected into the blood vessel through the perfusion cavity between the outer tube body and the optical fiber guide wire, the agents are uniformly released into the blood vessel through the perfusion holes, the action of the agents is promoted to be exerted under the auxiliary action of the optical fiber guide wire, and the therapeutic action of the agents is improved; the medicament used can be photosensitive liquid medicament or photosensitive hydrogel substance, and the medicament is uniformly dispersed to the inner wall of a blood vessel when in use, so that the treatment effect can be improved, the perfusion holes are arranged into two different forms, the medicament is uniformly sprayed out and dispersed to the inner wall of the blood vessel through the perfusion holes in different forms, the contact between the medicament and the inner wall of the blood vessel is improved, meanwhile, the irradiation area of light to the medicament on the inner wall of the blood vessel can be increased through the perfusion holes in different forms, and the medicament effect is improved.

Drawings

FIG. 1 is a schematic diagram of the structure of the device of the present invention;

FIG. 2 is a schematic view of the structure of the front end of the outer tube;

FIG. 3 is a schematic view of the structure of the front end of an optical fiber guide wire;

FIG. 4 is a schematic cross-sectional view of an optical fiber guide wire;

FIG. 5 is a schematic view of the structure of the tail end of the device;

FIG. 6 is a schematic view of a layout of circular holes and bar-shaped holes alternately arranged longitudinally;

FIG. 7 is a schematic diagram of a layout of alternating circular holes and transverse bar holes;

fig. 8 is a schematic layout of a staggered arrangement of circular holes and bar holes.

Reference numerals:

1. an outer tube body; 2. pouring holes; 3. an optical fiber guide wire; 4. a perfusion chamber; 5. a circular hole; 6. a bar-shaped hole; 7. a flexible probe; 8. an end hole; 9. a blocking member; 10. a sleeve; 11. an optical fiber; 12. and a light transmission area.

Detailed Description

So that the manner in which the features and techniques of the disclosed embodiments can be understood in more detail, a more particular description of the embodiments of the disclosure, briefly summarized below, may be had by reference to the appended drawings, which are not intended to be limiting of the embodiments of the disclosure. In the following description of the technology, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the disclosed embodiments. However, one or more embodiments may still be practiced without these details. In other instances, well-known structures and devices may be shown simplified in order to simplify the drawing.

The terms first, second and the like in the description and in the claims of the embodiments of the disclosure and in the above-described figures are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate in order to describe embodiments of the present disclosure. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion.

The term "plurality" means two or more, unless otherwise indicated.

In the embodiment of the present disclosure, the character "/" indicates that the front and rear objects are an or relationship. For example, A/B represents: a or B.

The term "and/or" is an associative relationship that describes an object, meaning that there may be three relationships. For example, a and/or B, represent: a or B, or, A and B.

The term "corresponding" may refer to an association or binding relationship, and the correspondence between a and B refers to an association or binding relationship between a and B.

It should be noted that, without conflict, the embodiments of the present disclosure and features of the embodiments may be combined with each other.

As shown in fig. 1-2, there is provided an intravascular fiber optic adjuvant therapy device comprising:

the perfusion device comprises an outer tube body 1, wherein a plurality of perfusion holes 2 are formed in one end of the outer tube body 1, which is led into a blood vessel, the perfusion holes 2 are circumferentially distributed on the side wall of the outer tube body 1, the perfusion holes 2 comprise two shapes, and the perfusion holes 2 with the two shapes are alternately and/or alternately arranged on the outer tube body 1;

the optical fiber guide wire 3, the optical fiber guide wire 3 is arranged in the outer tube body, and a perfusion cavity 4 is formed between the optical fiber guide wire 3 and the outer tube body 1.

In this embodiment, as can be seen from fig. 1, a plurality of pouring holes 2 are uniformly distributed at the front end of an outer tube body 1, an optical fiber guide wire 3 is arranged inside the outer tube body 1, a pouring cavity 4 is arranged between the optical fiber guide wire 3 and the outer tube body 1, when in use, a liquid preparation which is prepared in advance is poured into the pouring cavity 4 through an external preparation injection pump, a certain pressure is applied to the liquid preparation in the pouring cavity 4, under the action of the pressure, the preparation in the pouring cavity 4 is sprayed out from the pouring holes 2, and is in a spraying shape, because the pouring holes 2 are annularly distributed on the outer tube body 1, the sprayed medicament can be uniformly dispersed on the inner wall of a blood vessel, so that the inner wall of the blood vessel in a corresponding area is uniformly covered with the medicament, then the tail end of the optical fiber guide wire 3 is connected with an external laser source, and the laser emitted by the external laser source is transmitted into the outer tube body 1 through the optical fiber guide wire 3, and enters the blood vessel through irradiation at the pouring hole 2, the medicament on the inner wall of the blood vessel is activated or cured, and the like, so that the purpose of treatment is realized; the laser source may be turned on while the medicine is ejected from the pouring hole 2 according to the characteristics of the medicine, and the medicine may be activated or cured while being poured.

The medicament used in the process can be liquid preparation or hydrogel, and the laser emitted by the optical fiber guide wire 3 can be used for activating the medicament or solidifying the medicament, and the specific effect of the medicament is determined according to the characteristics of the medicament used and the treatment requirement. When the used medicament has a curing effect when encountering light, the medicament can be cured on the inner wall of the blood vessel by utilizing the characteristic of the medicament, so that the medicament forms a membranous structure on the inner wall of the blood vessel, the effects of slow release, blocking, treatment and the like of the medicament on the inner wall of the blood vessel are realized, and a novel targeted treatment idea is provided.

Preferably, the two different shapes of the pouring holes 2 are arranged on the outer tube body 1 in a longitudinal alternating manner, a transverse alternating manner, a longitudinal and transverse alternating manner and a longitudinal staggered manner.

In this embodiment, the pouring holes 2 with different shapes are arranged on the outer tube body 1 in a mode of longitudinal alternate arrangement, transverse alternate arrangement, longitudinal and transverse alternate arrangement, longitudinal alternate arrangement and the like, the specific arrangement mode is shown in fig. 2 and 6-8, the spraying effect of the medicament can be improved, when the medicament is a photo-curing medicament, the laser irradiation can also promote the medicament in the pouring holes 2 to be cured, so that the medicament blocks the pouring holes 2, the uniformity of the medicament covering the inner wall of a blood vessel is influenced, the pouring holes 2 are arranged into two different shapes, the aspect ratios of the different shapes are different, the probability that the pouring holes 2 are completely blocked is reduced, and the dispersion uniformity of the medicament in the blood vessel is improved.

Optimally, the two differently shaped pouring holes 2 comprise circular holes and bar-shaped holes.

Optimally, the diameter of the round hole is 80-120um, the length of the strip-shaped hole is 300-400um, the width of the strip-shaped hole is 80-120um, and four corners of the strip-shaped hole are arc-shaped.

Optimally, the distance between the circular holes and the strip-shaped holes is 150-200um.

In another embodiment of the present application, as shown in fig. 3, the device further comprises a flexible probe 7, optimally, the flexible probe 7 is arranged in a spiral shape, and one end of the outer tube body 1, which is introduced into a blood vessel, is arranged in a closed type or an open type;

when the end of the outer tube body 1, which is led into the blood vessel, is set to be closed, the flexible probe 7 is arranged at the free end of the outer tube body 1;

when the one end of the outer tube body 1 leading-in blood vessel is set to be open type, the free end of the outer tube body 1 is provided with an end hole 8, the flexible probe 7 is arranged at the free end of the optical fiber guide wire 3, and the flexible probe 7 penetrates through the end hole 8 and is arranged outside the outer tube body 1. Optimally, when the optical fiber guide wire 3 penetrates through the outer tube body 1, a blocking piece 9 is arranged between the optical fiber guide wire 3 and the flexible probe 7, and the blocking piece 9 is used for blocking the end hole 8.

In the above embodiment, the flexible probe 7 is of a double-spiral structure, the material of the flexible probe 7 is 316L stainless steel, the double-spiral structure has certain flexibility, can be bent under the action of external force and recover after the external force disappears, when the flexible probe 7 is pulled and led in the blood vessel, the flexible probe 7 can be bent along with the radian of the inner wall of the blood vessel, the advancing direction is changed, the hard damage to the inner wall of the blood vessel is avoided, and the leading-in smoothness and the use safety are improved.

In the above embodiment, including two different cases, when one end of the outer tube 1, which is introduced into a blood vessel, is set to be closed, the flexible probe 7 is disposed at the free end of the outer tube 1 and is fixedly connected with the outer tube 1 by means of bonding or the like, the diameter of the flexible probe 7 is 0.9-1.2mm, the diameter of the outer tube 1 is 5-6F (1f=0.333 mm), the diameter of the flexible probe 7 is far smaller than the diameter of the outer tube 1, and the flexible probe 7 is used as a traction component, so that the accuracy of inserting into the blood vessel can be improved, the flexibility of moving in the blood vessel can be improved, and the outer tube 1 can be drawn into the blood vessel; after being introduced to a specific position, the flexible probe 7 is always positioned in the blood vessel, and after the injection treatment of the medicine is completed, the flexible probe is withdrawn from the blood vessel together with the outer tube body 1.

In another case, when one end of the outer tube body 1, which is led into a blood vessel, is arranged in an open mode, an end hole 8 is formed in the free end of the outer tube body 1, a flexible probe 7 is arranged at the free end of the optical fiber guide wire 3 and is fixedly connected with the optical fiber guide wire 3 in a bonding mode and the like, and the flexible probe 7 penetrates through the end hole 8 and is arranged outside the outer tube body 1. Optimally, when the optical fiber guide wire 3 penetrates through the outer tube body 1, a plugging piece 9 is arranged between the optical fiber guide wire 3 and the flexible probe 7, the plugging piece 9 is used for plugging the end hole 8, the plugging piece 9 is made of 316L stainless steel, at the moment, the flexible probe 7 is fixedly connected with the optical fiber guide wire 3, and the function of the flexible probe is mainly to draw the optical fiber guide wire 3 to be inserted into the outer tube body 1, so that the optical fiber guide wire 3 is placed; the specific working process of the structure is as follows: the guide wire device in the prior art is inserted into the outer tube body 1 and penetrates out of the end hole 8, the outer tube body 1 is pulled to move in a blood vessel by utilizing the existing guide wire device, the outer tube body 1 is placed in a specific position in the blood vessel, the position of the outer tube body 1 is kept fixed, the guide wire device is pulled out of the outer tube body 1, then the optical fiber guide wire 3 is inserted into the outer tube body 1, in the inserting process, under the traction effect of the flexible probe 7 at the front end of the optical fiber guide wire 3, the optical fiber guide wire 3 is placed in the specific position in the outer tube body 1 in a smooth manner, after the optical fiber guide wire 3 is placed in the specific position, the flexible probe 7 penetrates out of the end hole 8 of the outer tube body 1, the end hole 8 is placed in the sealing piece 9, the end hole 8 is sealed by utilizing the sealing piece 9, the internal pressure of the outer tube body 1 is guaranteed to be sufficient, the problems that the pressure is insufficient when the subsequent medicament is sprayed out of the end hole 8 in the injection process, the medicament is not sprayed out of the perfusion hole 2, the problem of uneven spraying, the dosage is insufficient, and the treatment effect is affected are avoided.

As shown in fig. 2 and 3, the flexible probe 7 and the front end of the outer tube body 1 are both provided with an arc-shaped surface.

In the above embodiment, the front ends of the flexible probe 7 and the outer tube body 1 are provided with arc surfaces, so that the contact area with the inner wall of the blood vessel can be increased, the mechanical damage to the blood vessel in the process of introduction is avoided, the smoothness of the movement in the blood vessel is improved, and the safety and convenience of the device in use are improved.

As shown in fig. 4, the optical fiber guide wire 3 comprises a sleeve 10 and an optical fiber 11, the optical fiber 11 is arranged inside the sleeve 10, a light transmission area 12 is arranged on the sleeve 10, and the light transmission area 12 is arranged corresponding to the pouring hole 2.

In the above embodiment, the sleeve 10 is used for wrapping the optical fiber 11, at least one optical fiber 11 is arranged, and the optical fiber 11 is used as a light source for treatment and is used for activating or solidifying the medicament, so that the acting effect of the medicament is improved; the sleeve 10 is made of transparent materials, the sleeve 10 is made of a combination of a metal pipe and a transparent pipe, the sleeve is a hypotube, a layer of opaque coating is arranged on the inner wall of the sleeve 10, the coating is made of polytetrafluoroethylene generally, the coating can shield light emitted by an optical fiber, laser is prevented from activating or solidifying an unopened medicament in the infusion cavity 4, and the action effect of the medicament is reduced; the position of the sleeve 10 corresponding to the perfusion hole 2 is not provided with a coating, and the light emitted by the optical fiber 11 can act on the medicament on the inner wall of the blood vessel after being irradiated out through the sleeve 10, so that the light targeting auxiliary treatment is realized. The tail end of the optical fiber guide wire 3 is connected with an external laser light source. An annular developing mark is arranged on the sleeve 10 at intervals of 1-2cm, and is used for determining the position of the optical fiber guide wire 3 relative to the outer tube body 1 with the aid of an external developing device.

Claims

1. An endovascular fiber optic assisted treatment device, comprising:

the perfusion holes are circumferentially distributed on the side wall of the outer tube body, and at least comprise two shapes, and the perfusion holes in the two shapes are alternately and/or staggered on the outer tube body;

2. The endovascular fiber optic adjuvant therapy device according to claim 1, wherein said arrangement of two different shapes of said infusion holes on said outer body comprises one of a longitudinal alternating arrangement, a transverse alternating arrangement, a longitudinal and transverse alternating arrangement, and a longitudinal alternating arrangement.

3. An endovascular fiber optic adjuvant therapy device according to claim 1 or 2, wherein said infusion holes of two different shapes comprise a circular hole and a strip-shaped hole.

4. An endovascular optical fiber adjuvant therapy device according to claim 3, wherein said circular hole has a diameter of 80-120um, said bar-shaped hole has a length of 300-400um and a width of 80-120um, and four corners of said bar-shaped hole are arranged in an arc shape.

5. An endovascular fiber optic adjuvant therapy device according to claim 3, wherein the distance between said circular aperture and said bar-shaped aperture is 150-200um.

6. The endovascular fiber optic adjuvant therapy device according to claim 1 or 2, further comprising a flexible probe, wherein said outer catheter is configured to be either closed or open at one end of the catheter;

when one end of the outer tube body, which is led into the blood vessel, is set to be closed, the flexible probe is arranged at the free end of the outer tube body;

7. The endovascular fiber optic adjuvant therapy device according to claim 6, wherein a blocking member is disposed between the fiber optic guidewire and the flexible probe for blocking the end hole when the fiber optic guidewire is threaded through the outer tubular body.

8. An endovascular fiber optic adjuvant therapy device according to claim 6, wherein said flexible probe is helically-shaped.

9. The endovascular fiber optic adjuvant therapy device according to claim 6, wherein said flexible probe and said outer tubular body forward end are each configured as an arcuate surface.

10. The endovascular optical fiber adjuvant therapy device according to claim 1 or 2, wherein the optical fiber guide wire comprises a sleeve and an optical fiber, the optical fiber is disposed inside the sleeve, a light transmission region is disposed on the sleeve, and the light transmission region is disposed corresponding to the perfusion hole.