CN117582200A - Thrombus monitoring and compensating method and device - Google Patents
Thrombus monitoring and compensating method and device Download PDFInfo
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- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 116
- 238000012544 monitoring process Methods 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 27
- 239000008280 blood Substances 0.000 claims abstract description 73
- 210000004369 blood Anatomy 0.000 claims abstract description 73
- 230000002792 vascular Effects 0.000 claims abstract description 29
- 230000000903 blocking effect Effects 0.000 claims abstract description 23
- 238000013178 mathematical model Methods 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 9
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 20
- 238000012545 processing Methods 0.000 claims description 18
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 17
- 229910052737 gold Inorganic materials 0.000 claims description 17
- 239000010931 gold Substances 0.000 claims description 17
- 210000004204 blood vessel Anatomy 0.000 claims description 10
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 239000010936 titanium Substances 0.000 claims description 3
- 229910001362 Ta alloys Inorganic materials 0.000 claims description 2
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 2
- 229910001256 stainless steel alloy Inorganic materials 0.000 claims description 2
- 229910052715 tantalum Inorganic materials 0.000 description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- 230000008054 signal transmission Effects 0.000 description 6
- 239000002473 artificial blood Substances 0.000 description 5
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
- A61B5/02035—Determining blood viscosity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Abstract
The thrombus monitoring and compensating method is integrated on a vascular stent through a biocompatible film, and a potential difference signal set between an inert electrode and a plurality of working electrodes based on biocompatible metal-liquid contact potential is established, so that a mathematical model of the potential difference signal set and thrombus characteristic information is established; wherein the thrombus characteristic information comprises the thrombus blocking degree and the thrombus blocking position; and compensating the potential difference signal set according to the viscosity and the conductivity of the actual blood, and obtaining accurate thrombus characteristic information according to a mathematical model through the accurate potential difference signal set obtained after compensation. The thrombus early warning method and device can solve the problem that thrombus early warning cannot be directly, real-time and accurately carried out in the prior art.
Description
Technical Field
The application relates to the technical field of medical treatment, in particular to a thrombus monitoring and compensating method and device.
Background
At present, the thrombus detection method is mainly divided into two major categories, namely an imaging method and a non-imaging method. Imaging methods include angiography, ultrasound imaging, laser speckle contrast imaging, and the like, wherein the angiography methods require contrast agents, the ultrasound imaging methods require active signal emission, and the methods are widely used clinically, but cannot realize real-time monitoring of thrombus. Non-imaging methods, such as bioelectrical impedance method and near infrared spectroscopy, can realize real-time monitoring of thrombus and are simple to operate, but because the signal-to-noise ratio of measurement signals is low and the measurement result is greatly influenced by external environment, the measurement error is larger.
Therefore, real-time and accurate thrombus early warning is of great importance to the life health of the patient implanted with the stent.
Disclosure of Invention
The application provides a thrombus monitoring and compensating method and device, which can solve the problem that thrombus early warning cannot be directly, real-time and accurately carried out in the prior art.
The application provides a thrombus monitoring and compensating method, which comprises the following steps:
s1, establishing a mathematical model of a potential difference signal set and thrombus characteristic information through a potential difference signal set between an inert electrode and a plurality of working electrodes, wherein the inert electrode is based on biocompatible metal-liquid contact potential, and the potential difference signal set is integrated on a vascular stent through a biocompatible film; wherein the thrombus characteristic information comprises the thrombus blocking degree and the thrombus blocking position;
s2, compensating the potential difference signal set according to the viscosity and the conductivity of the actual blood, and obtaining accurate thrombus characteristic information according to a mathematical model through the accurate potential difference signal set obtained after compensation.
Optionally, step S1 specifically includes:
s11, implanting a vascular stent integrated with an inert electrode and a plurality of working electrodes through a biocompatible film into a hose simulating a blood vessel;
s12, pumping reference blood in a hose according to a fixed pulse rate and a fixed stroke volume;
s13, simulating different blocking degrees and blocking positions of thrombus in the hose;
s14, acquiring potential difference signal sets between the corresponding inert electrode and a plurality of working electrodes when simulating different thrombus blocking degrees and thrombus blocking positions in the hose;
s15, establishing a mathematical model of the potential difference signal set and thrombus characteristic information.
Optionally, in step S2, the set of potential difference signals is compensated according to the viscosity of the actual blood, and specifically includes the following steps:
A1. preparing simulated blood with different viscosities;
A2. acquiring potential difference signal sets in simulated blood with different viscosities;
A3. establishing a relation model between the viscosity in the simulated blood and the potential difference signal set;
A4. and compensating the potential difference signal set in the actual blood according to the viscosity data of the actual blood and a relation model between the viscosity in the simulated blood and the potential difference signal set.
Optionally, establishing a relation model of the viscosity in the simulated blood and the potential difference signal set specifically includes: and performing curve fitting on the viscosity and the potential difference signal set to obtain a relation model between the viscosity and the potential difference signal set.
Optionally, in step S2, compensating the set of potential difference signals according to the conductivity of the actual blood specifically includes the following steps:
B1. configuring simulated blood of different conductivities;
B2. acquiring potential difference signal sets in simulated blood with different conductivities;
B3. establishing a relation model between the conductivity in the simulated blood and the potential difference signal set;
B4. and compensating the potential difference signal set in the actual blood according to the conductivity data of the actual blood and a relation model between the simulated blood conductivity and the potential difference signal set.
Optionally, establishing a relationship model between the electrical conductivity and the set of potential difference signals in the simulated blood specifically includes: and performing curve fitting on the conductivity and the potential difference signal set to obtain a relation model between the conductivity and the potential difference signal set.
Optionally, the working electrode is made of one of tantalum, titanium, stainless steel and nickel-titanium alloy; the material of the inert electrode is one of gold, silver and platinum.
The application also provides a thrombus monitoring and compensating device, comprising:
a vascular stent;
an inert electrode and a plurality of working electrodes based on biocompatible metal-liquid contact potential integrated on the vascular stent through the biocompatible film;
the signal acquisition module is used for differentially amplifying potential difference signals of the inert electrode and the working electrodes and acquiring the potential difference signals through the analog-to-digital converter;
the wireless transmission module is used for wirelessly transmitting the acquired potential difference signals to external equipment by using an NFC (near field communication) technology;
the data processing and displaying module integrates a mathematical model and a compensation model between the potential difference signal set and thrombus characteristic information, and combines the potential difference signal set transmitted to external equipment with the viscosity and the conductivity of the actual blood to obtain and display accurate thrombus characteristic information; and
the power module is used for supplying power to the signal acquisition module and the microcontroller in a wireless mode through the wireless power supply transmitting unit, the power receiving coil, the bridge rectifier circuit and the filter circuit.
The scheme of the application has the following beneficial effects:
according to the thrombus monitoring and compensating method and device based on the thrombus, by establishing a model of potential difference signal sets and thrombus characteristic information of the inert electrode and the working electrodes and combining related physicochemical parameters, the influence of the potential difference signal sets is compensated, so that the time-space resolution and measuring precision of thrombus monitoring and early warning are improved, the volumes of the working electrode and the inert electrode are small, the surrounding hemodynamic parameters cannot be greatly influenced, the adopted biocompatible metal material can be directly contacted with blood, and the thrombus can be stably measured for a long time, so that the thrombus can be monitored and early warned in real time and accurately.
Other advantages of the present application will be described in detail in the detailed description section that follows.
Drawings
FIG. 1 is a schematic flow chart of a thrombus monitoring and compensation method provided herein;
FIG. 2 is a schematic diagram showing the relationship between the potential difference between the tantalum and the gold electrode and the degree of thrombus blockage;
FIG. 3 is a schematic diagram of the relationship between the potential difference between the tantalum and the gold electrode and the thrombus occurrence distance;
FIG. 4 is a schematic diagram of the relationship between the potential difference between the tantalum and gold electrodes and the viscosity in simulated blood;
FIG. 5 is a schematic diagram showing the relationship between the potential difference between the tantalum and gold electrodes and the electrical conductivity in simulated blood
FIG. 6 is a schematic block diagram of a thrombus monitoring and compensation device provided herein;
FIG. 7 is a schematic view of a thrombus monitoring and compensation device provided herein;
fig. 8 is a side view of the thrombus monitoring and compensation device of fig. 7.
[ reference numerals description ]
1. A vascular stent; 2. a wireless signal receiving module; 3. a power module; 31. a wireless power supply transmitting unit; 32. the power receiving coil; 33. a bridge rectifier circuit; 34. a filter circuit; 4. a data processing and display module; 5. a biocompatible film; 6. a signal acquisition module; 61. a differential amplifying circuit; 62. an analog-to-digital converter; 7. a wireless signal transmitting module; 8. a microcontroller; 9. an inert electrode; 10. a working electrode.
Detailed Description
In the following description, for purposes of explanation and not limitation, specific details are set forth, such as particular system configurations, techniques, etc. in order to provide a thorough understanding of the embodiments of the present application. It will be apparent, however, to one skilled in the art that the present application may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.
It should be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It should also be understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
As used in this specification and the appended claims, the term "if" may be interpreted as "when..once" or "in response to a determination" or "in response to detection" depending on the context. Similarly, the phrase "if a determination" or "if a [ described condition or event ] is detected" may be interpreted in the context of meaning "upon determination" or "in response to determination" or "upon detection of a [ described condition or event ]" or "in response to detection of a [ described condition or event ]".
In addition, in the description of the present application and the appended claims, the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and are not to be construed as indicating or implying relative importance.
Reference in the specification to "one embodiment" or "some embodiments" or the like means that a particular feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments of the application. Thus, appearances of the phrases "in one embodiment," "in some embodiments," "in other embodiments," and the like in the specification are not necessarily all referring to the same embodiment, but mean "one or more but not all embodiments" unless expressly specified otherwise. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless expressly specified otherwise.
At present, thrombus early warning cannot be directly, real-time and accurately carried out in the prior art.
In view of the above problems, the present application provides a thrombus monitoring and compensation method, as shown in fig. 1, comprising the steps of:
s1, establishing a mathematical model of a potential difference signal set and thrombus characteristic information through a potential difference signal set between an inert electrode and a plurality of working electrodes, wherein the inert electrode is based on biocompatible metal-liquid contact potential, and the potential difference signal set is integrated on a vascular stent through a biocompatible film; wherein the thrombus characteristic information comprises the thrombus blocking degree and the thrombus blocking position;
s2, compensating the potential difference signal set according to the viscosity and the conductivity of the actual blood, and obtaining accurate thrombus characteristic information according to a mathematical model through the accurate potential difference signal set obtained after compensation.
According to the potential difference signal set between each working electrode and the inert electrode, a mathematical model is established with thrombus characteristic information, and the thrombus characteristic information can be obtained through the potential difference signal set; the potential difference signal set is compensated through the influence of the viscosity and the conductivity of the actual blood, so that an accurate potential difference signal is obtained, and further accurate thrombus characteristic information is obtained.
According to the thrombus monitoring compensation method, a mathematical model is built with thrombus characteristic information according to potential difference signal sets between each working electrode and each inert electrode, and the thrombus characteristic information can be obtained through the potential difference signal sets; the potential difference signal set is compensated through the influence of the viscosity and the conductivity of the actual blood, so that an accurate potential difference signal is obtained, and further accurate thrombus characteristic information is obtained.
When thrombus occurs, potential difference signal sets between the inert electrode and the working electrodes based on the biocompatible metal-liquid contact potential are changed, wherein the inert electrode provides a relatively stable potential, and the potential of the working electrode is changed according to the thrombus condition; the degree of the potential difference change is related to the degree of thrombus blockage and the position of thrombus blockage, the greater the degree of the potential difference change, the smaller the potential difference signal when the upstream of the intravascular stent is blocked, and the larger the potential difference signal when the downstream of the intravascular stent is blocked.
In some embodiments of the present application, step S1 specifically includes:
s11, implanting a vascular stent integrated with an inert electrode and a plurality of working electrodes through a biocompatible film into a hose simulating a blood vessel;
s12, pumping reference blood in a hose according to a fixed pulse rate and a fixed stroke volume;
s13, simulating different blocking degrees and blocking positions of thrombus in the hose;
s14, acquiring potential difference signal sets between the corresponding inert electrode and a plurality of working electrodes when simulating different thrombus blocking degrees and thrombus blocking positions in the hose;
s15, establishing a mathematical model of the potential difference signal set and thrombus characteristic information.
In some embodiments of the present application, the material of the working electrode is one of tantalum, titanium, stainless steel, nickel-titanium alloy; the material of the inert electrode is one of gold, silver and platinum.
In the blood vessel, when the size or position of thrombus is changed, the potential of the working electrode is changed, but the potential of the inert electrode is basically unchanged, and the potential can be basically unchanged by selecting gold, silver and platinum as the inert electrode; the working electrode can be 316L stainless steel, nickel-titanium alloy and other materials, but tantalum is adopted as the material of the working electrode in the application, because tantalum has excellent corrosion resistance and good biocompatibility.
The following is an exemplary description of some embodiments provided herein:
taking tantalum and gold at fixed positions on an integrated vascular stent as working electrodes and inert electrodes respectively as examples, setting the pulse rate to be 60 times/min, the stroke volume to be 60mL, and the volume ratio to be 20:80 to simulate the density and viscosity of blood, as a reference blood. The tantalum vascular stent is implanted into an artificial blood vessel, the artificial blood vessel is made of expanded polytetrafluoroethylene, and the inner diameter of the artificial blood vessel is 6.4mm. The thrombus was simulated using a hollow polytetrafluoroethylene cylinder, the annular cross-sectional area of which was varied to control the degree of thrombus blockage (i.e., the size of the thrombus), and the outer diameter of which may be 6.4mm, as exemplified by the same inner diameter as the artificial blood vessel, and the inner diameter of which was varied to vary the degree of blockage.
As shown in FIG. 2, when the clogging degree was 0%, 40%, 60%, 99% at a distance of 4cm downstream of the tantalum electrode fixed to the stent, the potential difference Vpp between the obtained tantalum and gold was 6mV, 10mV, 15mV, 50mV in this order. Establishing a potential difference Vpp between tantalum and gold and the degree of thrombus blockage, and establishing a mathematical model between the tantalum and the gold by fitting, wherein the potential difference Vpp is as follows: y=6e-05 x 3 -0.0031x 2 +0.1208x+6. Where y represents the potential difference Vpp between tantalum and gold electrodes and x represents the degree of thrombus occlusion.
As shown in FIG. 3, when the degree of clogging was 70%, the potential difference signals were obtained at a distance of 4cm, 3cm, 2cm, 1cm, 0.5cm, 0cm upstream of the fixation of the position of the clogging to the vascular stent, 8mV, 6.64mV, 5.4mV, 4.8mV, 4.3mV, 3.5mV in this order. The mathematical model between Vpp and the distance between the simulated thrombus and the vascular stent is established as follows: y= -0.0172d 5 +0.1252d 4 -0.188d 3 -0.2649d 2 +
1.1249d+2.1. Where y represents the potential difference Vpp between tantalum and gold electrodes and d represents the thrombus formation distance.
In some embodiments of the present application, in step S2, the set of potential difference signals is compensated according to the viscosity of the actual blood, specifically comprising the steps of:
A1. preparing simulated blood with different viscosities;
A2. acquiring potential difference signal sets in simulated blood with different viscosities;
A3. establishing a relation model between the viscosity in the simulated blood and the potential difference signal set;
A4. and compensating the potential difference signal set in the actual blood according to the viscosity data of the actual blood and a relation model between the viscosity in the simulated blood and the potential difference signal set.
In some embodiments of the present application, establishing a model of a relationship of viscosity in simulated blood to a set of potential difference signals specifically includes: and performing curve fitting on the viscosity and the potential difference signal set to obtain a relation model between the viscosity and the potential difference signal set.
As shown in fig. 4, the volume fraction of glycerol in the simulated blood is adjusted, and the volume fraction of glycerol in the simulated blood may represent viscosity, and the volume ratio of glycerol to water is 10: 90. 20: 80. 30: 70. 40:60 of four kinds of simulated blood with different viscosities, the pulse rate and the stroke volume were set to 60 times/min and 60mL, and potential difference signals in the simulated blood with different viscosities were obtained to be 11.93mV, 6.01mV, 3.94mV, and 2.59mV in this order. The model of the relationship between the potential difference signal and the viscosity is: y= -0.3009v+13.64. Where y represents the potential difference Vpp of tantalum and gold electrodes and v represents the glycerol volume fraction.
In some embodiments of the present application, in step S2, compensating the set of potential difference signals according to the conductivity of the actual blood specifically comprises the steps of:
B1. configuring simulated blood of different conductivities;
B2. acquiring potential difference signal sets in simulated blood with different conductivities;
B3. establishing a relation model between the conductivity in the simulated blood and the potential difference signal set;
B4. and compensating the potential difference signal set in the actual blood according to the conductivity data of the actual blood and a relation model between the simulated blood conductivity and the potential difference signal set.
In some embodiments of the present application, modeling the relationship between the conductivity and the set of potential difference signals in the simulated blood specifically includes: and performing curve fitting on the conductivity and the potential difference signal set to obtain a relation model between the conductivity and the potential difference signal set.
As shown in fig. 5, the conductivity of the simulated blood was adjusted to a volume ratio of 20:80, adding sodium chloride to the glycerin aqueous solution to adjust the conductivity, and setting the pulse rate and the stroke volume to 60 times per minute and 60mL in six groups of simulated blood with different conductivities of 14.3 mu S/cm, 132 mu S/cm, 1200 mu S/cm, 7740 mu S/cm, 11600 mu S/cm and 14400 mu S/cm respectively, so as to obtain potential difference signals between the tantalum vascular stent and the gold electrode in the simulated blood with different conductivities of 6mV, 1.71mV, 0.63mV, 0.096mV, 0.048mV and 0.04mV. The relation model established by fitting the potential difference signal and the conductivity is as follows: y= 54.602c -0.723 . Where y represents the potential difference Vpp between tantalum and gold electrodes and c represents the electrical conductivity.
The potential difference signal is a potential difference signal between a working electrode and an inert electrode which is measured independently, when the thrombus characteristic information is required to be obtained, the potential difference signal set between each working electrode and the inert electrode is taken, and the thrombus characteristic information is calculated through a multiple regression algorithm.
The present application also provides a thrombus monitoring and compensating device, as shown in fig. 6 to 8, for the above thrombus monitoring and compensating method, the thrombus monitoring and compensating device includes:
a vascular stent 1; an inert electrode 9 and a plurality of working electrodes 10 based on biocompatible metal-liquid contact potential integrated on the vascular stent 1 through the biocompatible film 5; the signal acquisition module 6 is used for differentially amplifying potential difference signals of the inert electrode 9 and the working electrodes 10 and acquiring the potential difference signals through the analog-to-digital converter 62; the wireless transmission module is used for wirelessly transmitting the acquired potential difference signals to external equipment by using an NFC (near field communication) technology; the data processing and displaying module 4 integrates a mathematical model and a compensation model between the potential difference signal set and thrombus characteristic information, and combines the potential difference signal set transmitted to external equipment with the viscosity and the conductivity of the actual blood to obtain and display accurate thrombus characteristic information; and a power module 3 for wirelessly supplying power to the signal acquisition module 6 and the microcontroller 8 through the wireless power supply transmitting unit 31, the power receiving coil 32, the bridge rectifier circuit 33 and the filter circuit 34.
The thrombus monitoring and compensating device comprises a vascular stent 1 and a vascular stent 1; an inert electrode 9 and a plurality of working electrodes 10 based on biocompatible metal-liquid contact potential integrated on the vascular stent 1 through the biocompatible film 5; the signal acquisition module 6 is used for differentially amplifying potential difference signals of the inert electrode 9 and the working electrodes 10 and acquiring the potential difference signals through the analog-to-digital converter 62; the wireless transmission module is used for wirelessly transmitting the acquired potential difference signals to external equipment by using an NFC (near field communication) technology; the data processing and displaying module 4 integrates a mathematical model and a compensation model between the potential difference signal set and thrombus characteristic information, and combines the potential difference signal set transmitted to external equipment with the viscosity and the conductivity of the actual blood to obtain and display accurate thrombus characteristic information; and the power module 3 is used for wirelessly supplying power to the signal acquisition module 6 and the microcontroller 8 through the wireless power supply transmitting unit 31, the power receiving coil 32, the bridge rectifier circuit 33 and the filter circuit 34, and the thrombus monitoring and compensating device is used for directly completing real-time and accurate early warning on thrombus.
In some embodiments of the present application, the thrombus monitoring and compensation device as shown in fig. 6 to 8 comprises a vascular stent 1, a wireless signal receiving module 2, a power module 3, a data processing and display module 4, and a signal acquisition module 6, a wireless signal transmitting module 7, a microcontroller 8, an inert electrode 9 and a plurality of working electrodes 10 integrated on the vascular stent 1 through a biocompatible film 5; the biocompatible film 5 is made of insulating materials, the signal acquisition module 6 is respectively and electrically connected with the inert electrode 9 and each working electrode 10, and the signal acquisition module 6 is used for acquiring potential difference between the inert electrode 9 and each working electrode 10; the microcontroller 8 is electrically connected to the signal acquisition module 6 and the wireless signal transmission module 7 respectively, the microcontroller 8 is used for receiving the potential difference signal and transmitting the potential difference signal to the wireless signal receiving module 2 through the wireless signal transmission module 7, the wireless signal receiving module 2 is electrically connected to the data processing and display module 4, the data processing and display module 4 is used for processing and converting the potential difference signal received by the wireless signal receiving module 2 into corresponding thrombus blocking degree and distance between thrombus and the vascular stent 1 and displaying the thrombus and the distance between the thrombus and the vascular stent 1 on the data processing and display module 4, and the power module 3 is used for supplying power to the signal acquisition module 6 and the microcontroller 8.
The thrombus monitoring and compensating device comprises a vascular stent 1, a wireless signal receiving module 2, a power module 3, a data processing and displaying module 4, a signal acquisition module 6 integrated on the vascular stent 1 through a biocompatible film 5, a wireless signal transmitting module 7, a microcontroller 8, an inert electrode 9 and a plurality of working electrodes 10; the biocompatible film 5 is made of insulating materials, the inert electrodes 9 are respectively and electrically connected with each working electrode 10 through the signal acquisition module 6, and the signal acquisition module 6 is used for acquiring potential differences between the inert electrodes 9 and each working electrode 10; the microcontroller 8 is respectively and electrically connected to the signal acquisition module 6 and the wireless signal transmission module 7, the microcontroller 8 is used for receiving potential difference signals and transmitting the potential difference signals to the wireless signal receiving module 2 through the wireless signal transmission module 7, the wireless signal receiving module 2 is electrically connected to the data processing and display module 4, the data processing and display module 4 is used for processing and converting the potential difference signals received by the wireless signal receiving module 2 into corresponding thrombus blocking degrees and displaying the distance between the corresponding thrombus blocking degrees and the vascular stent 1 in the data processing and display module 4, the power module 3 is used for supplying power to the signal acquisition module 6 and the microcontroller 8, fitting the potential difference between each working electrode 10 and the inert electrode 9 and the thrombus state in blood vessels, and real-time and accurate early warning of thrombus is directly completed through the thrombus monitoring and compensation device.
It should be noted that, the signal acquisition module 6, the wireless signal transmission module 7, the microcontroller 8, the inert electrode 9 and the working electrodes 10 can also be integrated on an artificial blood vessel, a medical catheter or a needle, and when integrated on a medical catheter or a needle, a wired signal transmission mode can be adopted to replace a wireless transmission mode in the application.
In some embodiments of the present application, as shown in fig. 6, the signal acquisition module 6 includes a differential amplifying circuit 61 and an analog-to-digital converter 62, the differential amplifying circuit 61 is electrically connected to each of the working electrode 10 and the inert electrode 9, respectively, an input terminal of the analog-to-digital converter 62 is electrically connected to an output terminal of the differential amplifying circuit 61, and an output terminal of the analog-to-digital converter 62 is electrically connected to the microcontroller 8.
The differential amplifying circuit 61 is used for collecting potential difference signals between each working electrode 10 and the inert electrode 9, and the analog-to-digital converter 62 is used for converting the potential difference signals collected by the differential amplifying circuit 61 into digital signals and transmitting the digital signals to the microcontroller 8.
In some embodiments of the present application, as shown in fig. 6, the power module 3 includes a wireless power transmitting unit 31 and a wireless power receiving unit integrated on the intravascular stent 1, and the wireless power receiving unit is electrically connected to the differential amplifying circuit 61 and the microcontroller 8.
In some specific embodiments, the wireless power supply transmitting unit 31 includes a power source, an inverter connected to the power source for converting dc power into ac power, and a wireless power supply transmitting coil, and the wireless power supply receiving unit includes a power receiving coil 32 integrated on the intravascular stent 1, a bridge rectifier circuit 33, and a filter circuit 34, where an output end of the power receiving coil 32 is electrically connected to an input end of the bridge rectifier circuit 33, an output end of the bridge rectifier circuit 33 is electrically connected to an input end of the filter circuit 34, a first output end of the filter circuit 34 is electrically connected to an input end of the differential amplifier circuit 61, and a second output end of the filter circuit 34 is electrically connected to an input end of the microcontroller 8.
The wireless power supply transmitting coil in the wireless power supply transmitting unit 31 is matched with the power receiving coil 32 in the wireless power supply receiving unit, and power supply is realized by utilizing a wireless power supply technology, and alternating current in the power receiving coil 32 is converted into direct current through the bridge rectifier circuit 33 and the filter circuit 34 to supply power for the differential amplifying circuit 61 and the microcontroller 8.
In some embodiments of the present application, the wireless signal transmitting module 7 includes an NFC transmitting coil, and the wireless signal receiving module 2 may be an NFC receiving coil.
The NFC transmitting coil transmits the potential difference signal transmitted by the microcontroller 8 to the NFC receiving coil through the NFC near field communication technology, the NFC receiving coil transmits the potential difference signal to the data processing and displaying module 4, and the data processing and displaying module 4 processes the potential difference signal received by the wireless signal receiving module 2 and converts the potential difference signal into corresponding thrombus characteristic information.
It can be understood that the data processing and displaying module 4 may be a fixed terminal such as a computer with a display, or a mobile terminal such as a mobile phone and an intelligent wearable device.
In the foregoing embodiments, the descriptions of the embodiments are emphasized, and in part, not described or illustrated in any particular embodiment, reference is made to the related descriptions of other embodiments.
While the foregoing is directed to the preferred embodiments of the present application, it should be noted that modifications and adaptations to those embodiments may occur to one skilled in the art and that such modifications and adaptations are intended to be comprehended within the scope of the present application without departing from the principles set forth herein.
Claims (8)
1. A thrombus monitoring and compensation method, comprising the steps of:
s1, establishing a mathematical model of a potential difference signal set and thrombus characteristic information through a potential difference signal set between an inert electrode and a plurality of working electrodes, wherein the inert electrode is based on biocompatible metal-liquid contact potential, and the potential difference signal set is integrated on a vascular stent through a biocompatible film; wherein the thrombus characteristic information comprises the thrombus blocking degree and the thrombus blocking position;
s2, compensating the potential difference signal set according to the viscosity and the conductivity of the actual blood, and obtaining accurate thrombus characteristic information according to a mathematical model through the accurate potential difference signal set obtained after compensation.
2. The thrombus monitoring and compensation method according to claim 1, wherein step S1 comprises:
s11, implanting a vascular stent integrated with an inert electrode and a plurality of working electrodes through a biocompatible film into a hose simulating a blood vessel;
s12, pumping reference blood in a hose according to a fixed pulse rate and a fixed stroke volume;
s13, simulating different blocking degrees and blocking positions of thrombus in the hose;
s14, acquiring potential difference signal sets between the corresponding inert electrode and a plurality of working electrodes when simulating different thrombus blocking degrees and thrombus blocking positions in the hose;
s15, establishing a mathematical model of the potential difference signal set and thrombus characteristic information.
3. The thrombus monitoring and compensation method according to claim 1, wherein in step S2, the set of potential difference signals is compensated according to the viscosity of the actual blood, specifically comprising the steps of:
A1. preparing simulated blood with different viscosities;
A2. acquiring potential difference signal sets in simulated blood with different viscosities;
A3. establishing a relation model between the viscosity in the simulated blood and the potential difference signal set;
A4. and compensating the potential difference signal set in the actual blood according to the viscosity data of the actual blood and a relation model between the viscosity in the simulated blood and the potential difference signal set.
4. The method for monitoring and compensating for thrombus according to claim 3 wherein modeling the relationship between the viscosity in the simulated blood and the set of potential difference signals comprises: and performing curve fitting on the viscosity and the potential difference signal set to obtain a relation model between the viscosity and the potential difference signal set.
5. The thrombus monitoring and compensation method according to claim 1, wherein in step S2, the compensation of the set of potential difference signals according to the conductivity of the actual blood comprises the following steps:
B1. configuring simulated blood of different conductivities;
B2. acquiring the potential difference signal sets in simulated blood with different conductivities;
B3. establishing a relation model between the conductivity in the simulated blood and the potential difference signal set;
B4. and compensating the potential difference signal set in the actual blood according to the conductivity data of the actual blood and a relation model between the simulated blood conductivity and the potential difference signal set.
6. The method of claim 5, wherein modeling the relationship between the set of electrical conductivity and potential difference signals in the simulated blood comprises: and performing curve fitting on the conductivity and the potential difference signal set to obtain a relation model between the conductivity and the potential difference signal set.
7. The thrombus monitoring and compensation method according to claim 1, wherein the working electrode is made of one of tantalum, titanium, stainless steel and nickel-titanium alloy; the material of the inert electrode is one of gold, silver and platinum.
8. A thrombus monitoring and compensating device for use in the thrombus monitoring and compensating method as in any one of claims 1-7 wherein said thrombus monitoring and compensating device comprises:
a vascular stent;
an inert electrode and a plurality of working electrodes based on biocompatible metal-liquid contact potential integrated on the vascular stent through the biocompatible film;
the signal acquisition module is used for differentially amplifying potential difference signals of the inert electrode and the working electrodes and acquiring the potential difference signals through the analog-to-digital converter;
the wireless transmission module is used for wirelessly transmitting the acquired potential difference signals to external equipment by using an NFC (near field communication) technology;
the data processing and displaying module integrates a mathematical model and a compensation model between the potential difference signal set and thrombus characteristic information, and combines the potential difference signal set transmitted to external equipment with the viscosity and the conductivity of the actual blood to obtain and display accurate thrombus characteristic information; and
the power module is used for supplying power to the signal acquisition module and the microcontroller in a wireless mode through the wireless power supply transmitting unit, the power receiving coil, the bridge rectifier circuit and the filter circuit.
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| CN202311761062.XA CN117582200A (en) | 2023-12-20 | 2023-12-20 | Thrombus monitoring and compensating method and device |
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| CN202311761062.XA CN117582200A (en) | 2023-12-20 | 2023-12-20 | Thrombus monitoring and compensating method and device |
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