CN117562651A

CN117562651A - Ablation device and ablation system

Info

Publication number: CN117562651A
Application number: CN202311709519.2A
Authority: CN
Inventors: 薛蔚; 董樑; 罗中宝; 杜新星; 张星光
Original assignee: Shanghai Ruidao Medical Technology Co ltd
Current assignee: Shanghai Ruidao Medical Technology Co ltd
Priority date: 2023-12-12
Filing date: 2023-12-12
Publication date: 2024-02-20

Abstract

An ablation device and an ablation system are provided, the ablation device including a housing, an ablation needle, and a drive mechanism. The accommodating cavity of the shell is provided with a first opening and an axis passing through the first opening; the at least one ablation needle each includes a needle body; the driving mechanism is positioned in the accommodating cavity and is configured to drive the needle body to move along the extending direction of the axis, and the needle body comprises a connecting part and an ablation part; the connecting part is in transmission connection with the driving mechanism and at least partially extends out of the accommodating cavity from the first opening; the ablation part is connected to one end of the connection part far away from the driving mechanism and is configured to generate an electric field; the drive mechanism is configured to drive the needle bodies of the ablation needles to the ablation position, such that all of the ablation portions are aligned along the extending direction of the axis when all of the needle bodies are in the ablation position and include a plurality of ablation needles. The ablation device provided by the disclosure has the advantages that the ablation area formed by a plurality of ablation parts arranged along the extending direction of the axis is more accurate, so that the accuracy of ablation can be improved.

Description

Ablation device and ablation system

Technical Field

At least one embodiment of the present disclosure relates to an ablation device and an ablation system.

Background

Irreversible electroporation (Irreversible Electroporation, IRE) ablation technology is a method of tissue ablation in which cells are destroyed by forming pores in the cell membrane by a high voltage electric field, resulting in cell necrosis or apoptosis. Irreversible electroporation ablation techniques can be used, for example, for ablation of tumors or proliferative tissue at the prostate site.

Disclosure of Invention

At least one embodiment of the present disclosure provides an ablation device comprising: a housing having a receiving cavity, wherein the receiving cavity has a first opening; at least one ablation needle, wherein the at least one ablation needle each comprises a needle body; a driving mechanism located in the accommodating cavity and configured to drive at least one of the needle bodies to move along an extending direction of an axis of the first opening, wherein the needle body of the ablation needle includes a connecting portion and an ablation portion; the connecting part is in transmission connection with the driving mechanism and at least partially extends out of the accommodating cavity from the first opening; the ablation part is connected to one end of the connection part far away from the driving mechanism and is configured to generate an electric field; the drive mechanism is further configured to drive the needle body of the at least one ablation needle to an ablation position such that all of the plurality of ablation portions are aligned along the direction of extension of the axis when all of the needle body is in the ablation position and the at least one ablation needle comprises a plurality of ablation needles.

For example, according to at least one embodiment of the present disclosure, when the needle bodies of the plurality of ablation needles are all in the ablation position, the ablation portions of the needle bodies of the plurality of ablation needles are on a straight line parallel to the axis away from the center point of one end of the corresponding connection portion.

For example, in accordance with at least one embodiment of the present disclosure, the connecting portion of the at least one ablation needle is parallel to the axis; the ablation portion of the at least one ablation needle is configured to intersect the corresponding connection portion when the needle body of the at least one ablation needle is in the ablation position.

For example, in accordance with at least one embodiment of the present disclosure, wherein the at least one ablation needle each further comprises an ablation needle catheter; the ablation needle guide tube of the at least one ablation needle is sleeved outside the corresponding needle body and is connected with the shell; the guide piece is sleeved outside one end, far away from the shell, of the ablation needle catheter of the at least one ablation needle, and a second opening is formed in the guide piece; the ablation portion is configured to protrude from the second opening when the needle body of the at least one ablation needle is in the ablation position.

For example, in accordance with at least one embodiment of the present disclosure, the guide is provided with a guide portion that guides deformation of the needle body of the at least one ablation needle; the guiding part is provided with a first opening, a second opening and a guiding part, wherein the first opening is provided with a first opening, the second opening is provided with a second opening, the guiding part is provided with a starting end, the end, close to the housing, of the guiding part is provided with a tail end, and the direction from the starting end to the tail end is arranged at an angle with the extending direction of the axis.

For example, in accordance with at least one embodiment of the present disclosure, the guide includes a guide portion and a notched portion; the notch portion is located on a side of the guide portion near the housing in an extending direction of the axis, and is configured to expose a portion of the needle body when the needle body enters the guide.

For example, in accordance with at least one embodiment of the present disclosure, the cross-sectional shape of the guide portion taken by a plane parallel to the plane of the second opening has an arcuate boundary; the arc of the arc boundary is greater than pi.

For example, in accordance with at least one embodiment of the present disclosure, the needle body includes an insulating surface and an electrode structure; the insulation surface is positioned on the ablation part, the electrode structure comprises a first electrode part and a second electrode part, and the first electrode part and the second electrode part are arranged on the insulation surface at intervals along the extending direction of the needle body; the electrode structure is configured to generate an electric field between the first electrode portion and the second electrode portion when electrically conductive.

For example, in accordance with at least one embodiment of the present disclosure, the ablation section includes an adjacent insulating region and a conductive region, the conductive region being located at an end of the ablation section remote from the connection section; the at least one ablation needle includes a plurality of ablation needles, the ablation portions of the plurality of ablation needles configured to form an electric field between adjacent two of the conductive regions when electrically conductive.

For example, an ablation device in accordance with at least one embodiment of the present disclosure further includes an endoscope conduit disposed within the receiving cavity and a flashback member, wherein a centerline of the endoscope conduit is parallel to the axis, the flashback member including a flashback cavity and a seal disposed within the flashback cavity on a side of the flashback cavity remote from the endoscope conduit; the flashback chamber is in communication with the endoscope conduit and is configured to allow liquid to circulate between the flashback chamber and the endoscope conduit.

For example, in accordance with at least one embodiment of the present disclosure, the seal decreases in size in a direction perpendicular to the axis from a side distal to the endoscope conduit to a side proximal to the endoscope conduit.

For example, in accordance with at least one embodiment of the present disclosure, the drive mechanism includes a magnet assembly slidably disposed over the endoscope catheter and coupled to the needle body, and a coil disposed about the magnet assembly; the coil is configured to generate a magnetic force to drive the magnet assembly to move along an extension direction of the axis when electrically conductive.

For example, in accordance with at least one embodiment of the present disclosure, the driving mechanism includes a coil mounting member connected to the housing, the coil being wound outside the coil mounting member; the magnet assembly comprises a magnet mounting member and a magnet, the magnet is sleeved outside the magnet mounting member, the needle body is connected with the magnet mounting member, and the magnet mounting member is arranged between the endoscope catheter and the coil mounting member; a dimension of the coil mounting member in an extending direction of the axis is larger than a dimension of the magnet mounting member in the extending direction of the axis; one end of the coil mounting member, which is away from the first opening in the extending direction of the axis, is provided with a limiting portion that partially overlaps the magnet in the extending direction of the axis.

For example, according to at least one embodiment of the present disclosure, the magnet mounting member includes a first stopper portion, a connecting portion, and a second stopper portion connected in order, the magnet being stopped between the first stopper portion and the second stopper portion; the first stop part is positioned at one side close to the first opening; the second stopper portion does not overlap the limit portion in the extending direction of the axis, and is located on one side of the center line of the magnet mounting member.

For example, an ablation device in accordance with at least one embodiment of the present disclosure further includes a first switch mechanism including a first pusher and a first switch located within the receiving cavity and configured to be operatively connected to the ablation host; the first pressing piece is configured to press against the first switch to close the first switch when the first pressing piece is acted on, so that the ablation host receives a control signal to control liquid to flow into the reflux cavity and the endoscope catheter.

For example, in accordance with at least one embodiment of the present disclosure, the first switch is further configured to slide in an extending direction of the axis relative to the housing when subjected to a force; the first switch mechanism further includes a second switch configured to close against the second switch during sliding to control the drive mechanism to drive the connection portion to move in an extending direction of the axis to the needle body in the ablation position.

For example, in accordance with at least one embodiment of the present disclosure, the first switch mechanism further comprises an elastic member; the elastic member is connected between the first switch and the housing and configured to apply an elastic force separating the first switch and the second switch from each other.

For example, an ablation device in accordance with at least one embodiment of the present disclosure further includes a second switching mechanism, wherein the second switching mechanism includes a second pusher and a third switch, the third switch being located within the receiving cavity and electrically connected to the drive mechanism; the second pressing piece is configured to close the third switch against the third switch when acted, so that the driving mechanism drives one end of the connecting part away from the ablation part to move away from the first opening along the extending direction of the axis.

At least one embodiment of the present disclosure provides an ablation system including an ablation device of at least one embodiment as described above and the ablation host.

For example, an ablation system in accordance with at least one embodiment of the present disclosure further includes a clamp, wherein the clamp includes a slip fit first portion and a second portion configured to have a clamping position during relative sliding; the shell comprises a shell main body and a mounting part which are connected with each other, and the first opening is positioned at one side of the mounting part away from the shell main body; the first portion includes a first clamping surface and the second portion includes a second clamping surface; the first portion and the second portion are configured to form a clamping space between the first clamping surface and the second clamping surface for clamping the mounting portion when in the clamping position.

For example, an ablation system according to at least one embodiment of the present disclosure further comprises a connector, wherein a side of the first portion facing the second portion is provided with a first ramp and a side of the second portion facing the first portion is provided with a second ramp; the extending directions of the first slide rail and the second slide rail are parallel to the extending direction of the axis; the connecting piece comprises a first end and a second end which are oppositely arranged in a first direction, and the first direction is perpendicular to the extending direction of the axis; the first end is in sliding fit with the first slide, and the second end is in sliding fit with the second slide.

For example, in accordance with at least one embodiment of the present disclosure, the first portion includes a first support surface and the second portion includes a second support surface; the first support surface and the second support surface are configured to collectively support the housing body; at least one of the first support surface and the second support surface is configured to interfit in shape with a surface of the housing body.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings of the embodiments will be briefly described below, and it is apparent that the drawings in the following description relate only to some embodiments of the present disclosure, not to limit the present disclosure.

FIG. 1 is a schematic illustration of an ablation device provided in accordance with at least one embodiment of the present disclosure;

FIG. 2 is a schematic partial structural view of an ablation needle provided by an example in at least one embodiment of the present disclosure;

FIG. 3 is a schematic view of a partial structure of an ablation needle provided by another example in at least one embodiment of the present disclosure;

FIG. 4 is a schematic structural view of a guide provided by an example in at least one embodiment of the present disclosure;

FIG. 5 is a side view of a guide provided by an example in at least one embodiment of the present disclosure;

FIG. 6 is a bottom view of a guide provided by an example in at least one embodiment of the present disclosure;

FIG. 7 is a schematic illustration of an internal structure of an ablation device as provided by an example in at least one embodiment of the disclosure;

FIG. 8 is a schematic partial cross-sectional view of an ablation device as provided by an example in at least one embodiment of the disclosure;

FIG. 9 is a schematic cross-sectional view of an outer tube provided as an example in at least one embodiment of the present disclosure;

FIG. 10 is a schematic cross-sectional view of an outer tube provided by another example in at least one embodiment of the present disclosure;

FIG. 11 is a schematic structural view of an outer tube provided as an example in at least one embodiment of the present disclosure;

fig. 12 is a schematic structural view of a magnet mounting member provided as an example in at least one embodiment of the present disclosure;

FIG. 13 is a schematic illustration of an ablation system provided by at least one embodiment of the present disclosure;

FIG. 14 is a schematic structural view of a first switch mechanism according to an example of at least one embodiment of the present disclosure;

FIG. 15 is a schematic diagram of another view of a first switch mechanism provided by an example in at least one embodiment of the present disclosure;

FIG. 16 is a schematic structural view of a first pressing member provided as an example in at least one embodiment of the present disclosure;

FIG. 17 is a schematic diagram of another view of an ablation device provided by an example in at least one embodiment of the disclosure;

FIG. 18 is a schematic partial structural view of an ablation system provided by an example in at least one embodiment of the present disclosure;

FIG. 19 is a schematic view of a clamp provided by an example in at least one embodiment of the present disclosure;

FIG. 20 is a schematic view of a first portion of a clamp provided by an example in at least one embodiment of the present disclosure;

FIG. 21 is a schematic view of a second portion of a clamp provided by an example in at least one embodiment of the present disclosure; and

fig. 22 is a schematic structural view of a support structure according to an example of at least one embodiment of the present disclosure.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present disclosure more apparent, the technical solutions of the embodiments of the present disclosure will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present disclosure. It will be apparent that the described embodiments are some, but not all, of the embodiments of the present disclosure. All other embodiments, which can be made by one of ordinary skill in the art without the need for inventive faculty, are within the scope of the present disclosure, based on the described embodiments of the present disclosure.

Unless defined otherwise, technical or scientific terms used in this disclosure should be given the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The terms "first," "second," and the like, as used in this disclosure, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items.

As used in this disclosure, features such as "perpendicular," "parallel," and "identical" are all inclusive of the strict meaning of "perpendicular," "parallel," "identical," etc., and "substantially perpendicular," "substantially parallel," "substantially identical," etc., and are meant to be within the scope of acceptable deviation from the specified value as determined by one of ordinary skill in the art, given the measurement and the error associated with the specified amount of measurement (i.e., limitations of the measurement system). "center" in embodiments of the present disclosure may include a strictly centered position in the geometric center as well as a substantially centered position within a small area around the geometric center. For example, "approximately" can mean within one or more standard deviations, or within 10% or 5% of the stated value.

Prostatic hyperplasia, also known as benign prostatic hyperplasia (Benign Prostatic Hyperplasia, BPH), is one of the common benign growth disorders in men. With the age, the prostate gland of the male is continuously enlarged, so that the middle-aged and old male has symptoms such as urine flow blockage and the like. Some data show that men over 60 years old have more than 50% of their incidence of benign prostatic hyperplasia. In the early stages of benign prostatic hyperplasia, some symptoms can be alleviated by medication, such as taking medications that relax smooth muscle, or taking medications that block androgens. However, the side effects of the drug are obvious and the drug for relieving smooth muscle tension may cause hypotension, headache and nasal obstruction. Drugs that block androgens may then directly affect male sexual function, such as decreased libido, erectile dysfunction, abnormal ejaculation, and female breast development. In addition, the medication also requires long-term administration, and once stopped, the lower urinary tract symptoms continue to worsen.

Transurethral prostatectomy (Transurethral Resection of the Prostate, TURP) is a common surgical treatment for patients with moderate to severe urinary system disease, using a U-ring to cut and ablate the proliferating prostate tissue. However, transurethral prostatectomy suffers from drawbacks such as increased surgical bleeding, increased complications, slow patient recovery, and the like. In addition to medical and surgical treatments, minimally invasive treatments such as steam ablation have the advantages of simple operation, small trauma, small bleeding during surgery, quick recovery of the patient, and the like, and are therefore becoming increasingly favored.

The principle of steam ablation is to utilize the heat energy of high-temperature steam to release, so that the tissue cells of the hyperplasia of the prostate are instantaneously necrotized and naturally absorbed by human body, thereby reducing the volume of the prostate and improving the symptoms of difficult urination, etc. However, the inventors of the present application found in the study that: patients receiving steam treatment may require longer urinary catheterization time and the duration of urination difficulty increases, and some patients may also develop adverse symptoms such as macroscopic hematuria, hemospermia, frequent urination, urgency, etc.; moreover, due to the thermal damage associated with steam ablation, vascular and neural damage may still occur, thereby affecting the patient's urinary control and sexual function. In addition, steam therapy is only suitable for patients with prostates between 30 g and 80 g, and the durability of steam therapy also has a certain problem.

Irreversible electroporation (Irreversible Electroporation, IRE) is a non-thermal ablative treatment technique that not only minimizes complications, preserves the patient's sexual function, but also does not cause thermal damage. Irreversible electroporation is a physical phenomenon that a phospholipid bilayer of a cell membrane acts in an ultrashort pulse mode under a high-voltage electric field of 1500-3000V to generate a penetrating electric potential, the cell membrane is subjected to double-electrical disintegration, and nanoscale hydrophilic pores are formed on the cell membrane. Such permanent pores lead to an imbalance in the intracellular and extracellular environments, ultimately inducing apoptosis.

The irreversible electroporation technology can be applied to the fields of prostatic hyperplasia, prostatic tumor, liver tumor, atrial fibrillation and the like. Taking the treatment of prostatic hyperplasia or prostatic tumor as an example, in the ablation device applying the irreversible electroporation technology, a minimally invasive perineum puncturing mode is mostly adopted, and a focus is reached through a straight electrode needle in a puncturing way, so that the focus is operated. This approach not only leaves a puncture needle hole, but also makes it difficult to visually see the lesion, requiring additional determination of the location of the lesion by the ultrasound device. In addition, the volume and position of the focus are not fixed, and the ablation accuracy of the ablation device is still to be improved.

At least one embodiment of the present disclosure provides an ablation device including a housing, at least one ablation needle, and a drive mechanism.

The housing has a receiving cavity with a first opening and an axis passing through the first opening. The at least one ablation needle each includes a needle body, and a drive mechanism is located within the receiving cavity and configured to drive movement of the at least one needle body in a direction of extension of the axis. The needle body of the ablation needle comprises a connecting part and an ablation part, wherein the connecting part is in transmission connection with the driving mechanism and at least partially extends out of the accommodating cavity from the first opening. The ablation portion is connected to an end of the connection portion remote from the drive mechanism and is configured to generate an electric field. The drive mechanism is further configured to drive the needle body of the at least one ablation needle to an ablation position such that all of the plurality of ablation portions are aligned along the direction of extension of the axis when all of the needle body is in the ablation position and the at least one ablation needle comprises a plurality of ablation needles.

According to the ablation device provided by the embodiment of the disclosure, the connecting part of the needle body in the ablation needle extends out of the accommodating cavity from the first opening, so that the ablation part on the needle body can be sent to a position far away from the shell. Taking the above-described ablation device for treating prostatic hyperplasia as an example, the ablation needle can be advanced from the urethra to the site of hyperplasia when the ablation device is in use. When the ablation part generates an electric field, the high-voltage pulse electric field acts on the focus such as the proliferation tissue and the like when the ablation device is used for ablating the focus, so that tissue cell membranes are subjected to irreversible electroporation and apoptosis. The driving mechanism can drive the needle body to move to the ablation position, and when the ablation needle is one, the tissue to be proliferated can be ablated accurately. When the proliferation tissue is large, the ablation portions of the plurality of ablation needles can form a wide range of electric fields for operation. Meanwhile, all the ablation parts are arranged along the extending direction of the axis, namely the arrangement direction of the ablation parts is consistent with the driving direction of the driving mechanism as much as possible, so that the ablation area formed by a plurality of ablation parts is more accurate, and the ablation accuracy of the ablation device is improved.

At least one embodiment of the present disclosure also provides an ablation system including the ablation device and the ablation host of the above embodiments.

An ablation device and an ablation system of some embodiments of the present disclosure are exemplarily described below with reference to the accompanying drawings.

Fig. 1 is a schematic structural view of an ablation device provided in at least one embodiment of the present disclosure. Fig. 2 is a schematic partial structural view of an ablation needle provided as an example in at least one embodiment of the present disclosure. Fig. 3 is a schematic view of a partial structure of an ablation needle provided in another example in at least one embodiment of the present disclosure.

Referring to fig. 1, at least one embodiment of the present disclosure provides an ablation device 1000, the ablation device 1000 including a housing 100, an ablation needle 200, and a drive mechanism 300. The housing 100 has a receiving chamber 100a, the receiving chamber 100a having a first opening 100b. The housing 100 can protect components within its receiving cavity 100 a.

As shown in fig. 1-3, each ablation needle 200 includes a needle body 210. It will be appreciated that the ablation needle 200 may be only one ablation needle 200 as shown in fig. 2, or may be two ablation needles 200 as shown in fig. 3. Of course, the ablation needle may also be three or more ablation needles, and the disclosure is not limited herein.

As shown in fig. 1, the driving mechanism 300 is located in the accommodating chamber 100a and configured to drive the needle body 210 to move in the extending direction of the axis L1 of the first opening 100 b. For example, the outer contour of the first opening 100b approximates a circle or an ellipse, and the axis L1 passes through the center point of the first opening 100 b. For example, the shape of the receiving chamber 100a approximates a cylinder or an elliptic cylinder. For example, referring to fig. 1, a portion of the receiving chamber 100a is cylindrical in shape, and the axis L1 is an axis of the cylindrical portion. As shown in fig. 1, the extending direction of the axis L1 is the left-right direction in fig. 1. When the ablation device 1000 is used, the driving mechanism 300 drives the needle body 210 to move along the extending direction of the axis L1, so that the needle body 210 can reach the position of the proliferation tissue to be ablated, thereby realizing precise ablation of the proliferation tissue.

As shown in fig. 1 to 3, the needle body 210 of the ablation needle 200 includes a connection portion 211 and an ablation portion 212. The connection portion 211 is drivingly connected to the driving mechanism 300, and is capable of transmitting the driving force of the driving mechanism 300 to the ablation portion 212 on the needle body 210. At least part of the connection portion 211 protrudes from the first opening 100b outside the accommodating chamber 100a, and can send the ablation portion 212 on the needle body 210 to a position distant from the housing 100. For example, in use of the ablation device 1000, the ablation needle 200 can be advanced from the urethra and reach the site of hyperplasia of the prostate. The ablation portion 212 is connected to an end of the connection portion 211 remote from the driving mechanism 300 and is configured to generate an electric field. By generating an electric field by the ablation portion 212, when the ablation device 1000 is used to ablate a lesion, a high-voltage pulse electric field is applied to the lesion, such as a hyperplastic tissue, to irreversibly electroporate and apoptosis the tissue cell membrane.

As shown in fig. 1-3, the drive mechanism 300 is further configured to drive the needle body 210 of the ablation needle 200 to move to an ablation position. For example, an ablation location refers to a location where ablation is to be performed. For example, an ablation site refers to a site where proliferating tissue is located. Referring to fig. 2, when the ablation needle 200 is one, the driving mechanism 300 drives the needle body 210 to move, so that the proliferated tissue can be precisely ablated. Referring to fig. 3, when all of the needle bodies 210 are in the ablation position and the ablation needle 200 includes a plurality of ablation needles 200, all of the plurality of ablation portions 212 are arranged along the extending direction of the axis L1. The ablation portion 212 of the plurality of ablation needles 200 is capable of forming a wide range of electric fields for operation when the proliferating tissue is large. Meanwhile, all the ablation portions 212 are arranged along the extending direction of the axis L1, that is, the arrangement direction of the ablation portions 212 is as consistent as possible with the driving direction of the driving mechanism 300, so that the ablation areas formed by the plurality of ablation portions 212 are more accurate, and the ablation accuracy of the ablation device 1000 is improved. It is to be understood that the spacing between the plurality of ablation portions 212 arranged along the extending direction of the axis L1 may be adjusted according to actual needs, and the embodiment of the present disclosure is not limited thereto.

At least one embodiment of the present disclosure provides an ablation device 1000 that, in use, allows an ablation needle 200 to be advanced from the urethra and to the site of the proliferating tissue and to be ablated using irreversible electroporation techniques by generating an electric field through the ablation portion 212. By providing one or more ablation needles 200, a targeted selection can be made based on the actual volume of the proliferating tissue. Moreover, all the ablation portions 212 are arranged along the extending direction of the axis L1, so that the ablation area formed by the plurality of ablation portions 212 is more precise by driving of the driving mechanism 300 according to the position of the proliferation tissue, and the ablation accuracy of the ablation device 1000 is improved.

In some examples, referring to fig. 3, when the needle bodies 210 of the plurality of ablation needles 200 are all in the ablation position, the ablation portions 212 of the needle bodies 210 of the plurality of ablation needles 200 are on a straight line L2 parallel to the axis L1 away from the center point of one end of the corresponding connection portion 211. For example, the end of the needle body 210 away from the housing 100 is in a needle tip shape, and the center point of the end of the ablation portion 212 away from the corresponding connection portion 211 is the center point of the needle tip of the needle body 210. The straight line L2 is parallel to the axis L1, so that the needle tips of the plurality of needle bodies 210 can reach the ablation position at the same time as much as possible. In other examples, a line at which the ablation portion is located away from a center point of one end of the corresponding connection portion may intersect the axis. In still other examples, the center point line of the end of the ablation portion remote from the corresponding connection portion is a fold line. It will be appreciated that the present disclosure is not limited in this regard as long as the ablation portion is capable of generating an electric field to effect ablation.

In some examples, referring to fig. 1-3, the connecting portion 211 of the ablation needle 200 is parallel to the axis L1. When the driving mechanism 300 drives the connection portion 211 to move, the connection portion 211 parallel to the axis L1 can reliably transmit the driving force in the extending direction of the axis L1. When the needle body 210 of the ablation needle 200 is in the ablation position, the ablation portion 212 of the ablation needle 200 is configured to intersect the corresponding connection portion 211. In use of the ablation device 1000, after the ablation needle 200 enters the urethra, the needle body 210 is driven by the driving mechanism 300 to move to an ablation position, and the ablation portion 212 intersecting the corresponding connection portion 211 can puncture the urethra to enter the tissue to be ablated to reach the ablation position. For example, the extending direction of the connection portion 211 and the extending direction of the ablation portion 212 have a predetermined angle therebetween. For example, the preset included angle is 85-95 °. It will be appreciated that the ablation portion 212 is bent substantially perpendicularly between the connection portion 211 when the needle body 210 is in the ablation position.

For example, the needle body 210 includes a shape memory material, which may be at least one of a shape memory alloy material or a shape memory flexible polymeric material. In this way, when the ablation device 1000 is used, the needle body 210 is substantially linear in shape during the insertion of the ablation needle 200 into the urethra, and when the ablation site is reached, the ablation portion 212 and the connection portion 211 can be disposed so as to intersect. For example, shape memory alloy materials include nickel-titanium alloys, copper-based alloys, iron-based alloys, and the like. For example, shape memory flexible polymeric materials include epoxy-based shape memory polymers, cyanate-based shape memory polymers, polyimide-based shape memory polymers, styrene-based shape memory polymers, polyetherketones (PEKs), and the like.

In some examples, referring to fig. 2, the needle body 210 includes an insulating surface 213 and an electrode structure 214. In combination with the foregoing example, when the needle body 210 includes the conductive material, a layer of insulating film may be wrapped on the outer surface of the conductive material, and the surface of the insulating film is the insulating surface 213 of the needle body 210. For example, the needle body 210 may include a shape memory alloy material, and an insulating film may be heat shrunk on an outer surface of the needle body 210. For example, when the needle body 210 includes an insulating material, the outer surface of the needle body 210 is the insulating surface 213. For example, the needle body 210 comprises a shape memory flexible polymeric material.

In some examples, the insulating surface 213 is located at the ablation portion 212, and the electrode structure 214 includes a first electrode portion 214a and a second electrode portion 214b, the first electrode portion 214a and the second electrode portion 214b being disposed on the insulating surface 213 at intervals from each other along the extending direction of the needle body 210. The electrode structure 214 is configured to generate an electric field between the first electrode portion 214a and the second electrode portion 214b when electrically conductive. It is understood that the first electrode portion 214a and the second electrode portion 214b of the electrode structure 214 are disposed on the ablation portion 212 of the needle body 210, so that when electrically conducted, an electric field is generated only on the ablation portion 212 of the needle body 210. For example, one of the first electrode portion 214a and the second electrode portion 214b is a positive electrode, and the other of the first electrode portion 214a and the second electrode portion 214b is a negative electrode, so that an electric field is generated between the positive electrode and the negative electrode. For example, the first electrode portion 214a is connected to the positive electrode or negative electrode of the ablation host in the later-described embodiment (for example, refer to fig. 13) by a cable, and the second electrode portion 214b is connected to the negative electrode or positive electrode of the ablation host by a cable.

For example, the first electrode part includes a plurality of first sub-electrodes (not shown in the drawing), and the second electrode part includes a plurality of second sub-electrodes (not shown in the drawing). The first sub-electrodes and the second sub-electrodes are alternately arranged along the extending direction of the needle body. For example, the first sub-electrode is a positive electrode or a negative electrode, and the second sub-electrode is a negative electrode or a positive electrode, respectively. In this way, ablation of the proliferation tissue can be achieved by generating an electric field between the first sub-electrode and the second sub-electrode (the positive electrode and the negative electrode arranged at intervals) alternately arranged in sequence.

For example, referring to fig. 2, at least one of the first electrode portion 214a and the second electrode portion 214b surrounds the ablation portion 212 to form a ring-shaped electrode. For example, the first electrode portion 214a and the second electrode portion 214b may be provided on the needle body 210 by welding or bonding. For example, the first electrode portion 214a and the second electrode portion 214b are both ring-shaped electrodes.

Fig. 2 illustrates only an example in which the ablation device includes one ablation needle, and in other examples, the ablation device may also include multiple ablation needles. It will be appreciated that where a plurality of ablation needles are provided, the ablation portion of the needle body of each ablation needle may be provided with an insulating surface and electrode structure, the disclosure being not limited thereto. The ablation needles are arranged in a plurality of ways, so that the discharge positions of the ablation device can be increased, the electric field range generated between ablation parts is larger, the ablation range is enlarged, the ablation device is suitable for treating the tissue with the hyperplasia of a larger size, and the operation time is shortened.

For example, in still other examples, the needle body is provided in at least two, the electrode structure includes a first electrode portion and a second electrode portion, and the sum of the number of the first electrode portion and the number of the second electrode portion is equal to the number of the needle bodies. The first electrode parts and the second electrode parts are sequentially and alternately arranged on at least two needle bodies so as to generate an electric field between the two adjacent needle bodies when the electric conduction is carried out. In this example, only one first electrode portion or one second electrode portion is provided on each needle body, and electrode portions having different electric potentials are provided on two adjacent needle bodies, respectively, so that an electric field is generated when electrically conducted. Through setting up a plurality of needle bodies, can increase the produced electric field scope of ablation part to can be applicable to the processing of the hyperplasia tissue of great size, reduce operating time.

Referring to fig. 3, in some examples, the ablation portion 212 includes an adjacent insulation region Z1 and a conductive region Z2, the conductive region Z2 being located at an end of the ablation portion 212 remote from the connection portion 211. For example, the material of the needle body 210 includes a conductive material. For example, the material of the needle body 210 includes a shape memory alloy material. For example, the outer surface of the ablation portion 212 is heat-shrunk with an insulating film to form an insulating region Z1, and an end of the ablation portion 212 remote from the connection portion 211 is exposed outside the insulating film to form a conductive region Z2. The ablation needle 200 includes a plurality of ablation needles 200, and the ablation portion 212 of the plurality of ablation needles 200 is configured to form an electric field between adjacent two conductive regions Z2 when electrically conductive. By connecting the adjacent two needle bodies 210 to the positive and negative electrodes of the ablation host in the later-described embodiment (for example, refer to fig. 13) through cables, respectively, the adjacent two ablation portions 212 can generate an electric field to perform ablation when electrically conducted. It will be appreciated that when a plurality of ablation needles 200 are provided, the range of electric fields generated by ablation portion 212 can be increased, thereby enabling adaptation to the treatment of larger-sized proliferating tissue, and reducing the operating time.

In some examples, referring to fig. 1-3, each ablation needle 200 further includes an ablation needle catheter 220, the ablation needle catheter 220 of the ablation needle 200 being sleeved outside the corresponding needle body 210 and connected to the housing 100. For example, in use of the ablation device 1000, the catheter 220 can be wrapped around the needle body 210 by ablation to facilitate access to the urethra. Furthermore, ablation needle catheter 220 can also provide protection for needle body 210. For example, during entry of the ablation needle 200 into the urethra, the needle body 210 is retracted within the ablation needle catheter 220 and moved with the ablation needle catheter 220 to the site of the proliferating tissue. When the driving mechanism 300 drives the needle body 210 to move to the ablation position, the needle body 210 moves relative to the ablation needle catheter 220, and the ablation portion 212 is deformed to intersect the connection portion 211, thereby puncturing the urethra and entering the hyperplastic tissue.

In connection with the foregoing example, the needle body 210 is a shape memory material (e.g., a shape memory alloy material or a shape memory flexible polymeric material), and the needle body 210 may be processed into a curved shape at the time of processing such that the ablation portion 212 is disposed intersecting the connection portion 211. When the ablation portion 212 of the needle body 210 is positioned in the ablation catheter 220, the ablation portion 212 is deformed to have a substantially linear shape with the connection portion 211 due to the blocking of the ablation catheter 220. When the ablation portion 212 is extended from the ablation catheter 220 by the driving force of the driving mechanism 300, the ablation portion 212 is restored to the original curved shape, thereby being restored to the intersecting arrangement with the connection portion 211.

Fig. 4 is a schematic structural view of a guide provided as an example in at least one embodiment of the present disclosure. Fig. 5 is a side view of a guide provided by an example in at least one embodiment of the present disclosure. Fig. 6 is a bottom view of a guide provided by an example in at least one embodiment of the present disclosure.

In some examples, referring to fig. 2 or 3, in combination with fig. 4, a guide 400 is sleeved over the end of the ablation needle catheter 220 of the ablation needle 200 distal from the housing 100, thereby enabling guiding the ablation needle catheter 220 into the urethra. It will be appreciated that when the ablation needle 200 is configured as one shown in fig. 2, the guide 400 is positioned over one ablation needle catheter 220. When the ablation needle 200 is configured as two or more as shown in fig. 3, the guide 400 is sleeved outside the two or more ablation needle catheters 220. The guide 400 is provided with a second opening 410, and when the needle body 210 of the ablation needle 200 is in the ablation position, the ablation portion 212 is configured to protrude from the second opening 410, so that the needle body 210 is guided to bend by the guide 400 to deform.

For example, the dimension d1 of the ablation portion 212 extending out of the second opening 410 in the extending direction thereof is less than 20 mm. For example, the ablation portion 212 may have a spacing of less than 20 millimeters from an end of the connecting portion 211 that is distal from the plane of the second opening 410. For example, in combination with some of the foregoing examples (e.g., see fig. 3), the ablation portion 212 includes an adjacent insulating region Z1 and a conductive region Z2, the conductive region Z2 being located in a circumferential region of the ablation portion 212 extending beyond the second opening 410. For example, the conductive zone Z2 has a dimension in the direction of extension of the ablation portion 212 of less than 20 millimeters. For example, the dimension may be 18 mm, 16 mm, 14 mm, 12 mm, 10 mm, etc., although other values are possible, as embodiments of the present disclosure are not limited in this respect.

In some examples, referring to fig. 4 and 5, the guide 400 is provided with a guide 420 that guides the deformation of the needle body 210 of the ablation needle 200. For example, the material of the needle body 210 is a shape memory material, and the guide portion 420 can assist the deformation of the needle body 210 along the guide track of the guide portion 420 while the needle body 210 is subjected to memory deformation, so as to avoid the deflection of the needle body 210 during the deformation process. In some examples, an end of the guide 420 near the housing 100 is a start end a, an end of the guide 420 near the second opening 410 is a finish end B, and a direction L3 from the start end a to the finish end B is disposed at an angle to an extending direction of the axis L1. As such, the guide portion 420 is capable of guiding the ablation portion 212 of the needle body 210 to be bent and deformed toward the second opening 410 when the driving mechanism 300 drives the needle body 210 to move in the extending direction of the axis L1.

In some examples, as shown in fig. 4, the guide 420 includes a guide portion 421 and a notch portion 422. The guide portion 421 is a portion capable of guiding the deformation of the needle body 210, and the guide 420 formed by the notch portion 422 and the guide portion 421 has a substantially groove shape. The notch portion 422 is located on a side of the guide portion 421 near the housing 100 in the extending direction of the axis L1, and is configured to expose a part of the needle body 210 when the needle body 210 enters the guide 400. In this manner, after the needle body 210 enters the guide 400, the needle body 210 can be intuitively seen through the notch portion 422, thereby facilitating the operator to judge the position of the needle body 210. Of course, as shown in fig. 5, the guide portion may be configured like a tubular structure, that is, without providing a notch portion on the guide portion, which is not limited in the embodiment of the present disclosure.

For example, in connection with some examples described below, the ablation device 1000 further includes an endoscopic catheter for endoscopic access, and the guide 400 is sleeved outside of the endoscopic catheter and the ablation needle catheter 220. For example, the guide 400 includes a transparent polymer material, and after an endoscope is introduced into the guide 400 through an endoscope catheter, the urethra can be observed through the transparent guide 400. For example, referring to fig. 4 or 5, the guide 400 is further opened at both sides of its center line with a third opening 430, and the condition of the urethra can be easily more clearly observed by the endoscope through the third opening 430. In addition, the second opening 410 and the two third openings 430 formed on the guide 400 also make the openings of the guide 400 not easy to deform.

In some examples, referring to fig. 4 and 6, the cross-sectional shape of the guide portion 421 taken by a plane parallel to the plane of the second opening 410 has an arc boundary S having an arc of greater than pi. It will be appreciated that the arc angle of the arcuate boundary S is greater than 180 °. In this way, the guide portion 421 can surround the needle body 210 by more than half a circumference, thereby reliably guiding the deformation of the needle body 210. In addition, the needle body 210 is substantially cylindrical, and the guide portion 421 can more closely conform to the shape of the needle body 210, and also can prevent the needle body 210 from being damaged when the guide needle body 210 is deformed.

For example, referring to fig. 6, two guide portions 420 are provided in the guide 400, and the two guide portions 420 are aligned along the extending direction of the axis L1, thereby guiding the ablation portions 212 of the two needle bodies 210 to be bent and deformed and aligned along the extending direction of the axis L1. For example, in order to avoid blocking when the two needle bodies 210 enter the corresponding guide portions 420, a straight line L where the center points of the two guide portions 420 are located is disposed to intersect with the extending direction of the axis L1, that is, the two guide portions 420 are disposed to be offset. For example, the center points of the two guiding portions 420 are both close to the axis L1, so that the center point connecting line L2 of the ablation portion 212 is parallel to the axis L1 after the guiding needle body 210 is deformed.

Fig. 7 is a schematic diagram illustrating an internal structure of an ablation device provided by an example in at least one embodiment of the present disclosure, and fig. 8 is a schematic partial cross-sectional view of an ablation device provided by an example in at least one embodiment of the present disclosure.

In some examples, referring to fig. 7 and 8, the ablation device further includes an endoscopic catheter 500 and a reflux 600 disposed within the containment lumen 100 a. For example, the endoscope catheter 500 is used for endoscope access, which is capable of observing not only the ablation site during ablation, but also the needle body 210 of the ablation needle 200. The centerline of the endoscope conduit 500 is parallel to the extending direction of the axis L1, thereby facilitating observation of the endoscope in the endoscope conduit 500. For example, the centerline of the endoscope catheter 500 coincides with the axis L1. For example, an endoscope can be passed through the flashback member 600 into the endoscope catheter 500, and an end of the endoscope catheter 500 remote from the flashback member 600 protrudes out of the accommodation cavity 100a from the first opening 100 b.

For example, an endoscope attachment member 101 connected to the housing 100 is further provided in the housing chamber 100 a. For example, the endoscope attachment member 101 is integrally structured with the housing 100. For example, the endoscope attachment member 101 can provide a supporting force for an endoscope that enters the endoscope guide 500, and after the endoscope enters the endoscope guide 500, an eyepiece end of the endoscope can be placed on the endoscope attachment member 101 for observation. For example, after the endoscope has been introduced into the endoscope catheter 500, the direction rotation and the stroke change can be performed as needed, so that the position of the needle body 210 and the state of the urethra can be observed by adjusting the position of the endoscope. For example, the objective end of the endoscope has a lens of a preset angle to observe through the second opening 410. For example, the predetermined angle may be 12 °, 30 °, or other angles, which embodiments of the present disclosure are not limited to.

For example, a mounting plate 102 is also provided in the housing chamber 100a and is connected to the housing 100. For example, the reflow 600 may be mounted on the mounting plate 102. For example, the mounting plate 102 is of unitary construction with the housing 100. For example, a part of the structure of the driving mechanism 300 is mounted on the mounting plate 102. For example, in conjunction with some examples described later, the coil mounting member 330 in the drive mechanism 300 is mounted on the mounting plate 102.

Fig. 9 is a schematic cross-sectional view of an outer tube provided by an example in at least one embodiment of the present disclosure, fig. 10 is a schematic cross-sectional view of an outer tube provided by another example in at least one embodiment of the present disclosure, and fig. 11 is a schematic structural view of an outer tube provided by an example in at least one embodiment of the present disclosure.

For example, the endoscope catheter 500 and the ablation needle catheter 220 are secured together by an outer tube 550. For example, fig. 9 shows a schematic view of an outer tube 550 securing an endoscope catheter 500 with one ablation needle catheter 220, and fig. 10 and 11 show schematic views of an outer tube 550 securing an endoscope catheter 500 with two ablation needle catheters 220. For example, both the endoscope catheter 500 and the ablation needle catheter 220 comprise stainless steel material, and the outer tube 550 is a heat shrink film. For example, the endoscope catheter 500 and the ablation catheter 220 are welded together and then heat shrunk by the heat shrink film outer tube 550 to be integrally fixed. For example, referring to fig. 7 in combination with the previous example, the outer tube 550 and the guide 400 may be glued together by glue.

For example, referring to fig. 11, the needle body 210 is sheathed with a protective tube 230, and the protective tube 230 can protect the ablation portion 212 of the needle body 210 from smoothly entering the ablation catheter 220 when the needle body 210 is mounted to the ablation catheter 220. For example, the radial dimension of the protective tube 230 is greater than the radial dimension of the opening of the end of the ablation catheter 220 distal from the housing 100. In this manner, after the ablation portion 212 of the needle body 210 passes through the ablation catheter 220, the protective tube 230 does not follow the needle body 210 out of the ablation catheter 220.

In some examples, referring to fig. 7 and 8, the flashback member 600 includes a flashback chamber 610 and a seal 620, the seal 620 being disposed within the flashback chamber 610 on a side distal from the endoscope catheter 500, the flashback chamber 610 being in communication with the endoscope catheter 500 and configured to allow liquid to pass between the flashback chamber 610 and the endoscope catheter 500. For example, the liquid is normal saline. For example, the scope tube of the endoscope passes through the seal 620 and the flashback chamber 610 through a through hole in the flashback member 600 into the endoscope catheter 500. For example, the radial dimension of the endoscope conduit 500 is larger than the radial dimension of the scope tube of the endoscope, and after the scope tube of the endoscope enters the endoscope conduit 500, the liquid can flow to the second opening 410 of the guide 400 via the annular gap between the scope tube and the endoscope conduit 500, thereby flushing the site where the second opening 410 is located.

For example, in connection with some examples described below (e.g., as may be seen in connection with fig. 13 and with reference to fig. 8), a liquid, such as saline, is pumped by the pump body into the return chamber 610 via a feed tube in the infusion tube and flows through the annular gap to the second opening 410 for flushing. Due to the pressure differential at the second opening 410, the flushed saline can flow back into the return 600 and out through the outlet tube in the infusion tube. For example, the reflux member 600 is further provided with a liquid inlet and a liquid outlet (not shown), wherein the liquid inlet is communicated with the liquid inlet, and the liquid outlet is communicated with the liquid outlet, so that physiological saline can enter the reflux cavity 610 from the liquid inlet and flow out of the reflux cavity 610 from the liquid outlet. For example, the liquid inlet and the liquid outlet are provided at a side of the return 600 facing the first opening 100 b. For example, the position of the liquid inlet is disposed closer to the endoscope mounting member 101 than the position of the liquid outlet. It will be appreciated that in order to facilitate viewing of the eyepiece end of the endoscope, the position of the endoscope mounting member 101 relative to the ground in the in-use condition is higher. For example, the liquid inlet is located closer to the endoscope mounting member 101, i.e., the liquid inlet is located higher relative to the liquid outlet, so that liquid is liable to flow out from the liquid outlet at a relatively lower position.

In some examples, referring to fig. 8, in a direction perpendicular to axis L1, dimension D1 of seal 620 gradually decreases from a side distal from endoscope catheter 500 to a side proximal to endoscope catheter 500. It will be appreciated that the seal 620 is generally tapered. For example, the seal 620 is a flexible seal 620. In this manner, the seal 620 is better able to seal around the circumference of the endoscope's scope after the endoscope's scope has passed through the seal 620 into the flashback chamber 610.

In some examples, referring to fig. 7 and 8, the drive mechanism 300 includes a magnet assembly 310 and a coil 320, the magnet assembly 310 being slidably disposed over the endoscope catheter 500 and coupled to the needle body 210. It should be noted that, the electromagnetic driving mechanism 300 is adopted in the examples of the present disclosure, and other driving manners, such as magnetic driving, spring driving, etc., may be adopted in other examples, which are not limited in this disclosure. For example, the magnet assembly 310 is configured to move the needle body 210 when slid relative to the endoscope catheter 500. The coil 320 is disposed around the magnet assembly 310. For example, the plurality of coils 320 are provided, and the plurality of coils 320 are arranged along the extending direction of the axis L1. In some examples, coil 320 is configured to generate a magnetic force to drive magnet assembly 310 to move along the extension direction of axis L1 when electrically conductive. In this way, by means of electromagnetic driving, the structure of the driving mechanism 300 can be simplified, and the magnet assembly 310 can be stably driven to move, thereby stably driving the needle body 210 to move.

For example, referring to fig. 7 and 8, two coils 320 are wound around the magnet assembly 310, and the current directions of the two coils 320 after being energized are opposite, so that a magnetic force that attracts each other can be generated. In this way, the two coils 320 can drive the magnet assembly 310 to move close to or away from the first opening 100b, and when one of the coils 320 is energized, the needle body 210 can be driven to extend from the second opening 410 of the guide 400, and when the other coil 320 is energized, the needle body 210 can be driven to retract into the guide 400. In other examples, the magnet assembly surrounds a coil (not shown) that may be connected to both loops. By switching on one circuit at a time, the two circuits respectively supply currents in different directions to the coil, so that magnetic fields in opposite directions can be generated.

In some examples, the drive mechanism 300 includes a coil mounting member 330 coupled to the housing 100, with the coil 320 wound outside the coil mounting member 330. As such, the coil mounting member 330 can provide a mounting location for the coil 320. The magnet assembly 310 includes a magnet mounting member 311 and a magnet 312, the magnet 312 is sleeved outside the magnet mounting member 311, the needle body 210 is connected to the magnet mounting member 311, and the magnet mounting member 311 is disposed between the endoscope catheter 500 and the coil mounting member 330. The magnet mounting member 311 can provide a mounting location for the magnet 312 and the needle body 210. After the magnet 312 is driven by the magnetic force generated by the energizing of the coil 320, the magnet mounting member 311 can be driven to slide relative to the endoscope catheter 500, so as to drive the needle body 210 to move along the extending direction of the axis L1. For example, a space for restricting the magnet 312 in a direction perpendicular to the axis L1 is formed between the coil mounting member 330 and the magnet mounting member 311. For example, upon installation, the endoscope conduit 500 passes through the magnet mounting member 311, thereby enabling the magnet 312 to be captured between the magnet mounting member 311 and the coil mounting member 330.

In some examples, a dimension D2 of the coil mounting member 330 in the extending direction of the axis L1 is greater than a dimension D3 of the magnet mounting member 311 in the extending direction of the axis L1. In this way, the coil 320 wound on the coil mounting member 330 can reliably drive the magnet 312 and the magnet mounting member 311 to move. For example, during movement of the magnet assembly 310 relative to the coil mounting member 330, the orthographic projection of the magnet assembly 310 in a direction perpendicular to the axis L1 is always located within the orthographic projection of the coil mounting member 330 in a direction perpendicular to the axis L1.

In some examples, the coil mounting member 330 is provided with a stopper 331 at an end thereof remote from the first opening 100b in the extending direction of the axis L1, the stopper 331 partially overlapping the magnet 312 in the extending direction of the axis L1. In this way, the stopper 331 on the coil mounting member 330 can restrict the maximum movement distance of the magnet 312 when the magnet 312 moves away from the first opening 100 b. For example, the case 100 includes a case main body 110 and a mounting portion 120 connected to each other, the first opening 100b is located at a side of the mounting portion 120 remote from the case main body 110, and a dimension of the mounting portion 120 in an extending direction perpendicular to the axis L1 is smaller than a dimension of the case main body 110 in an extending direction perpendicular to the axis L1, so that a maximum movement distance d2 of the magnet 312 toward the first opening 100b is limited by an end of the mounting portion 120 connected to the case main body 110. For example, the maximum movement distance d2 of the magnet 312 and the magnet mounting member 311 in the extending direction of the axis L1 is restricted by the stopper 331 on the mounting portion 120 and the coil mounting member 330 together, thereby restricting the movement distance of the needle body 210 in the extending direction of the axis L1. For example, the maximum movement distance d2 is less than 20 mm. For example, in connection with the previous examples (e.g., see fig. 2 and 3), the maximum movement distance d2 is equal to the dimension d1 of the ablation portion 212 of the needle body 210 extending out of the second opening 410. In this manner, the size of the ablation portion 212 extending out of the second opening 410 can be met, as well as ensuring that the ablation portion 212 is fully retracted into the guide 400 when the drive mechanism 300 drives the needle body 210 to retract.

Fig. 12 is a schematic structural view of a magnet mounting member provided as an example in at least one embodiment of the present disclosure. In some examples, referring to fig. 8 and 12, the magnet mounting member 311 includes a first stopper portion 311a, a connection portion 311b, and a second stopper portion 311c connected in order, and the magnet 312 may be stopped between the first stopper portion 311a and the second stopper portion 311 c. In this way, the relative positional relationship between the magnet 312 and the magnet mounting member 311 can be restricted by the first stopper portion 311a and the second stopper portion 311 c. In some examples, the first stop portion 311a is located on a side close to the first opening 100b, and the second stop portion 311c does not overlap the limit portion 331 in the extending direction of the axis L1. In this way, the second stopper portion 311c does not interfere with the stopper portion 331 of the coil mounting member 330 during movement of the magnet 312 and the magnet mounting member 311, and the structure is more compact, shortening the dimension of the accommodating chamber 100a in the extending direction of the axis L1.

In some examples, referring to fig. 12, the second stopper 311c is located on one side of the center line L4 of the magnet mounting member 311. In this way, the magnet 312 can be more easily fitted over the magnet mounting member 311, and the assembly between the components is facilitated. For example, the center line L4 of the magnet mounting member 311 coincides with the axis L1 shown in fig. 8. Of course, in other examples, the second stop portions may also be located on opposite sides of the centerline of the magnet mounting member, and the second stop portions may also be disposed circumferentially about the connection portion, neither of which is limiting in this disclosure.

Fig. 13 is a schematic diagram of an ablation system provided by at least one embodiment of the present disclosure. Fig. 14 is a schematic structural diagram of a first switching mechanism provided in an example in at least one embodiment of the present disclosure. Fig. 15 is a schematic view of another view of the first switching mechanism provided by an example in at least one embodiment of the present disclosure. Fig. 16 is a schematic structural view of a first pressing member provided as an example in at least one embodiment of the present disclosure. Fig. 17 is a schematic diagram of another view of an ablation device provided in accordance with an example in at least one embodiment of the present disclosure.

As shown in fig. 13, at least one embodiment of the present disclosure provides an ablation system including an ablation device 1000 and an ablation host 10 as in at least one embodiment described above. Since the ablation system according to the embodiments of the present disclosure includes the ablation device 1000 described above, the corresponding advantageous technical effects are also provided, and will not be described here again.

Referring to fig. 8, 13 and 14, the ablation device 1000 further includes a first switching mechanism 700, the first switching mechanism 700 including a first pusher member 710 and a first switch 720, the first switch 720 being positioned within the receiving chamber 100a and configured to be operatively connected to the ablation host 10. For example, referring to fig. 14 to 17, the first pressing piece 710 is partially located inside the receiving cavity 100a and partially located outside the receiving cavity 100a, thereby facilitating the pressing operation by the operator.

For example, referring to fig. 13, the ablation system further includes an irrigation device 30, the irrigation device 30 includes a liquid storage tank 31, a pump body 32 and an infusion tube 33, one end of the infusion tube 33 is communicated with the liquid storage tank 31, the other end is communicated with a reflux member 600 in the ablation device 1000, and the pump body 32 is connected to a middle portion of the infusion tube 33 for adjusting a flow rate of the liquid in the infusion tube 33. For example, the pump body 32 is a peristaltic pump. For example, the pump body 32 is operatively connected to the ablation host 10, and parameters of the pump body 32 can be adjusted and operation of the pump body 32 controlled by the ablation host 10. For example, the pump body 32 is provided with an adjustment knob, and the rotation speed of the pump body 32 can be adjusted by the adjustment knob, so that the flow rate of the liquid such as physiological saline can be adjusted, and the urethra can be irrigated as needed. For example, a wire winding groove 34 is provided on the pump body 32, and the cable in the ablation system can be wound in the wire winding groove 34.

As shown in fig. 13, in combination with fig. 8 and 14, the first press 710 is configured to close the first switch 720 against the first switch 720 when acted upon, such that the ablation host 10 receives a control signal to control the flow of fluid into the flashback chamber 610 and the endoscope catheter 500. For example, the first switch 720 includes a switch portion 721 and a circuit board 722, the switch portion 721 being operatively connected to the ablation host 10 through the circuit board 722. For example, by closing the first switch 720 by pressing the first pressing member 710, the ablation host 10 can control the physiological saline to perform the urethral irrigation. For example, the ablation host 10 controls the operation of the pump body 32 such that saline flows from the fluid reservoir 31 through the infusion tube 33 and is pumped by the pump body 32 into the reflux member 600. In connection with the previous example, saline flows from the reflux member 600 into the annular gap between the endoscope catheter 500 and the scope tube of the endoscope and to the second opening 410 of the guide member 400, effecting irrigation of the urethra. Of course, in other examples, a conduit through which the physiological saline may be separately provided, which is not limited by the present disclosure. For example, the housing 100 is further provided with a wire outlet 130 for extending the cable, the infusion tube 33, the liquid outlet tube, etc. out of the housing 100.

For example, referring to fig. 15 and 16, the first pressing piece 710 includes a pressing portion 711 and a drop-preventing portion 712 connected to each other, the pressing portion 711 being configured to close the first switch 720 against the first switch 720 when receiving a force, the drop-preventing portion 712 being capable of being engaged with the housing 100 to prevent the drop-off of the first pressing piece 710. For example, the pressing portion 711 is provided with an engagement groove 711a toward one side of the first switch 720. For example, when the first pressing member 710 is acted upon, the engaging groove 711a can receive at least part of the first switch 720, so that the first switch 720 is more reliably closed. For example, the first switch 720 is configured as a switch capable of rebound reset, and after the force applied by the first pressing member 710 is removed, the first switch 720 is rebound reset to be turned off, and at the same time, the first pressing member 710 is driven to reset.

In some examples, the first switch 720 is further configured to slide in an extending direction of the axis L1 relative to the housing 100 when subjected to a force. For example, in combination with the foregoing examples (e.g., reference may be made to fig. 7 and 8), the first switch may be mounted on the endoscope mounting member and configured to be slidable relative to the endoscope mounting member. For example, in combination with the foregoing example, the first switch may be mounted on the case main body of the case and configured to be slidable with respect to the case main body. Of course, the present disclosure is not limited in this regard. For example, in connection with the foregoing example, a sliding plate 723 is provided on a side of the circuit board 722 remote from the switch portion 721, and a slide rail (not shown in the drawing) is provided on the housing 100, with which the sliding plate 723 is slidably fitted, thereby achieving relative sliding between the first switch 720 and the housing 100.

In some examples, referring to fig. 8 and 14, the first switch mechanism 700 further includes a second switch 730, the first switch 720 being configured to close the second switch 730 against the second switch 730 during sliding to control the driving mechanism 300 to drive the connecting portion 211 to move in the extending direction of the axis L1 to the needle body 210 in the ablation position. For example, the second switch 730 is located on one side of the first switch 720 in the extending direction of the axis L1. For example, in connection with the previous example, during sliding of the first switch 720, the sled 723 can close the second switch 730 against the second switch 730.

It will be appreciated that by depressing the first pusher member 710 during use of the ablation device 1000, the urethra can be irrigated prior to the control needle body 210 extending from the second opening 410, allowing a better view of the endoscope to view the urethra. The first switch mechanism 700 of the above-described embodiment of the present disclosure, through one first pressing piece 710, can also drive the needle body 210 to protrude to be in the ablation position while the urethral irrigation is being achieved. While pressing the first pressing piece 710, the operator applies force to the first pressing piece 710 to slide the first switch 720 relative to the housing 100 to close the second switch 730, so that the driving mechanism 300 drives the needle body 210 to extend out of the second opening 410 of the guide 400, puncture the urethra and reach the position where the proliferated tissue is located. In the process, the physiological saline can be continuously washed, so that the operator can observe and use the physiological saline conveniently.

For example, referring to fig. 13, the above-described ablation system further includes an ablation pedal 40 operatively connected to the ablation host 10. The ablation pedal 40 is configured such that when a force is applied, for example, when an operator depresses the ablation pedal 40, the ablation host 10 receives the depression signal to excite the ablation portion 212 of the needle body 210, thereby ablating the proliferated tissue. In connection with the foregoing example, referring to fig. 14, after closing the second switch 730 by pushing the first push piece 710, the ablation portion 212 of the needle body 210 punctures the urethra and reaches the position where the proliferated tissue is located, and the operator depresses the ablation pedal 40 to trigger the electrode structure 214 of the ablation portion 212 shown in fig. 2 to discharge or to trigger the conductive region Z2 of the ablation portion 212 shown in fig. 3 to discharge, thereby ablating the proliferated tissue. For example, the ablation host 10 generates a high voltage pulse to trigger the discharge of the ablation portion 212 to ablate.

In some examples, the first switching mechanism 700 further includes an elastic member 740. The elastic member 740 is, for example, a spring. The elastic member 740 is connected between the first switch 720 and the case 100, and is configured to apply an elastic force to separate the first switch 720 and the second switch 730 from each other. Referring to fig. 14, the second switch 730 is located at one side of the first switch 720 in the extending direction of the axis L1, and the elastic member 740 is elastically connected between the first switch 720 and the housing 100 along the extending direction of the axis L1. In this way, after the force applied by the first pressing member 710 is removed, the elastic member 740 rebounds to drive the first switch 720 to slide relative to the housing 100 away from the second switch 730, so that the second switch 730 is turned off.

In some examples, referring to fig. 17 in combination with fig. 14 and 8, ablation device 1000 also includes a second switching mechanism 800, second switching mechanism 800 including a second pusher 810 and a third switch (not shown) positioned within receiving chamber 100a and electrically connected to drive mechanism 300. For example, the pressing and closing manner of the second pressing member 810 and the third switch may be exactly the same as the pressing and closing manner of the first pressing member 710 and the first switch 720. Of course, the third switch may be closed in other manners, and embodiments of the disclosure are not limited thereto. In some examples, the second press 810 is configured to close the third switch against the third switch when acted upon to cause the drive mechanism 300 to drive an end of the connecting portion 211 away from the ablation portion 212 to move away from the first opening 100b in the extending direction of the axis L1. It will be appreciated that the second pressing member 810, when pressed to close the third switch, can cause the driving mechanism 300 to retract the needle body 210 into the guide 400. In connection with the previous example, the needle body 210 can be caused to protrude through the second opening 410 by closing the second switch 730 and ablate multiple regions of the prostate lobe. After ablation is completed, the needle body 210 can be retracted by closing the third switch, and the ablation device 1000 is withdrawn from the patient, ending the ablation procedure.

Fig. 18 is a schematic partial structural view of an ablation system provided by an example in at least one embodiment of the present disclosure. Fig. 19 is a schematic structural view of a clamp provided by an example in at least one embodiment of the present disclosure. Fig. 20 is a schematic structural view of a first portion of a clamp provided by an example in at least one embodiment of the present disclosure. Fig. 21 is a schematic structural view of a second portion of a clamp provided by an example in at least one embodiment of the present disclosure.

In some examples, referring to fig. 18 and 19, the ablation system further includes a clamp 20, the clamp 20 including a slip fit first portion 01 and a second portion 02, the first portion 01 and the second portion 02 configured to have a clamping position during relative sliding. For example, the first portion 01 and the second portion 02 can slide relatively in a direction parallel to the extending direction of the axis L1 in the ablation device 1000. The case 100 includes a case main body 110 and a mounting part 120 connected to each other, and the first opening 100b is located at a side of the mounting part 120 remote from the case main body 110. For example, the dimension of the mounting portion 120 in the direction perpendicular to the axis L1 is smaller than the dimension of the case main body 110 in the direction perpendicular to the axis L1. For example, in connection with the previous examples, the mounting portion 120 is sleeved outside the outer tube 550, the ablation needle catheter 220, and the endoscope catheter 500.

In some examples, referring to fig. 19-21, the first portion 01 includes a first clamping surface 011 and the second portion 02 includes a second clamping surface 021. The first portion 01 and the second portion 02 are configured such that a clamping space P for clamping the mounting portion 120 is formed between the first clamping surface 011 and the second clamping surface 021 when in the clamping position. In this manner, by adjusting the relative positions of the first portion 01 and the second portion 02, the mounting portion 120 of the housing 100 in the ablation device 1000 can be securely clamped, thereby providing support for the ablation needle catheter 220 and the endoscope catheter 500. For example, at least one of the first clamping surface 011 and the second clamping surface 021 is configured to interfit in shape with a surface of the mounting portion 120. For example, the first clamping surface 011 and the second clamping surface 021 are each configured to interfit in shape with the surface of the mounting section 120. In this way, the first and second clamping surfaces 011 and 021 can better conform to the surface of the mounting portion 120, thereby better supporting the mounting portion 120.

For example, an orthographic projection of the first clamping surface 011 on a plane perpendicular to the axis L1 includes a first arcuate profile C1, and an orthographic projection of the second clamping surface 021 on a plane perpendicular to the axis L1 includes a second arcuate profile C2, the arc of the first arcuate profile C1 being greater than the arc of the second arcuate profile C2. In this way, the attachment portion 120 of the ablation device 1000 can be positioned by the first clamping surface 011, and then the attachment portion 120 can be clamped by adjusting the position of the second clamping surface 021 with respect to the first clamping surface 011. For example, the sum of the radian of the first arc-shaped contour C1 and the radian of the second arc-shaped contour C2 is 2pi, that is, the first arc-shaped contour C1 and the second arc-shaped contour C2 can be spliced to form a circle, so as to match the shape of the mounting portion 120. For example, the first arcuate profile C1 has an arc of 1.5 pi and the second arcuate profile C2 has an arc of 0.5 pi. Of course, the radian of the first arc-shaped profile and the radian of the second arc-shaped profile can be adjusted according to actual needs, and the radian of the first arc-shaped profile can be larger than or equal to the radian of the second arc-shaped profile, which is not limited in the disclosure.

In some examples, further comprising a connector 03, a first portion 01 is provided with a first slideway 012 on a side facing the second portion 02, and a second portion 022 is provided on a side of the second portion 02 facing the first portion 01. The extending directions of the first slideway 012 and the second slideway 022 are parallel to the extending direction of the axis L1, and the connecting piece 03 comprises a first end 031 and a second end 032 which are oppositely arranged in a first direction x, wherein the first direction x is perpendicular to the extending direction of the axis L1. The first end 031 is in sliding engagement with the first slideway 012 and the second end 032 is in sliding engagement with the second slideway 022. In this way, the first end 031 of the connector 03 can slide along the extending direction of the axis L1 relative to the first slideway 012, and the second end 032 of the connector 03 can slide along the extending direction of the axis L1 relative to the second slideway 022. For example, the connector 03 further includes a connecting end 033 connected between the first end 031 and the second end 032, the connecting end 033 being configured to connect to a bracket structure in some examples described below. For example, the connector 03 is generally constructed in a T-shaped structure as shown in fig. 19. For example, the first end 031 is complementary in shape to the first ramp 012 and the second end 032 is complementary in shape to the second ramp 022, thereby making sliding of the first end 031 in the first ramp 012 and sliding of the second end 032 in the second ramp 022 smoother.

In some examples, the first portion 01 includes a first support surface 013 and the second portion 02 includes a second support surface 023, the first support surface 013 and the second support surface 023 being configured to collectively support the housing body 110. In this way, the first and second holding surfaces 011 and 021 of the clamp 20 hold the mounting portion 120, and at the same time, a stable supporting force can be provided to the case main body 110 by the first and second supporting surfaces 013 and 023. In some examples, at least one of the first support face 013 and the second support face 023 is configured to interfit in shape with a surface of the housing body 110. For example, the first support surface 013 and the second support surface 023 are each configured to interfit in shape with the surface of the housing body 110. For example, the first support surface 013 and the second support surface 023 are both arcuate surfaces. As such, the shapes of the first and second support surfaces 013 and 023 can be better fitted with the surface of the case main body 110, thereby more stably supporting the case main body 110. It is understood that the dimensions of the first support surface 013 and the second support surface 023 in the extending direction of the axis L1 do not need to be the same as the dimensions of the case main body 110 in the extending direction of the axis L1, for example, the dimensions of the first support surface 013 and the second support surface 023 in the extending direction of the axis L1 are 1/3 to 1/2 of the dimensions of the case main body 110 in the extending direction of the axis L1. Of course, the present disclosure example is not limited thereto as long as the first support surface 013 and the second support surface 023 can be ensured to stably support the case main body 110.

For example, the clamp 20 further includes a locking member 04, the locking member 04 being capable of passing through the first portion 01 and the second portion 02 to lock the first portion 01 and the second portion 02. For example, the first portion 01 is provided with a first screw groove 014, the second portion 02 is provided with a second screw groove 024, and the locking member 04 is screwed into the first screw groove 014 and the second screw groove 024 to lock the first portion 01 and the second portion 02. In connection with the previous example, after the locking member 04 locks the first portion 01 and the second portion 02, the first clamping surface 011 and the second clamping surface 021 can reliably clamp the mounting portion 120, and at the same time, the first slideway 012 and the second slideway 022 can also clamp the connecting member 03 together. For example, the connector 03 is used to connect to a bracket structure in the example described below.

Fig. 22 is a schematic structural view of a support structure according to an example of at least one embodiment of the present disclosure. As shown in fig. 22, for example, the carriage structure 50 includes a plurality of arms connected in sequence, adjacent two of the plurality of arms being configured to be rotatable relative to each other. For example, referring to fig. 13, the bracket structure 50 has one end for fixed connection with the console 60 and the other end for connection with the clamp 20. The operator can rotate the arms as needed to adjust the angle between adjacent two arms, thereby facilitating adjustment of the clamp 20 and the position of the ablation device 1000 held by the clamp 20. For example, the plurality of arms includes a first arm 51, a second arm 52, a third arm 53, and a fourth arm 54 connected in sequence, the first arm 51 for connection to the console 60, and the fourth arm 54 for connection to the clamp 20. For example, the fourth arm 54 is adapted to be coupled to the connector 03 in the clamp 20.

For example, the support structure 50 further includes a bedside clip 55 for holding the console 60, the bedside clip 55 being connected to an end of the first arm 51 remote from the second arm 52. For example, the bedside clamp 55 includes two clamping portions 55a provided at a spacing, the two clamping portions 55a being configured to be movable relative to each other to adjust a spacing between the two clamping portions 55a so that the console 60 is clamped by the two clamping portions 55 a. For example, the bedside clamp 55 also includes a first fastener 55b, the first fastener 55b being configured to adjust the spacing between the two clamp portions 55a, thereby ensuring that the two clamp portions 55a are reliably secured to the console 60. For example, the bedside clip 55 also includes a second fastener 55c, the second fastener 55c being used to secure the first arm 51 to the bedside clip 55.

For example, one of the first arm 51 and the second arm 52 includes a spherical portion, and the other includes a spherical recess, with which the spherical portion is in close fit. For example, referring to fig. 18, the first arm 51 includes a spherical portion 51a and the second arm 52 includes a spherical recess 52a. For example, the spherical recess may comprise an elastic rubber material, and the spherical portion may be rotatable about 360 ° with respect to the spherical recess when subjected to an external force, thereby allowing relative rotation between the first arm 51 and the second arm 52. It will be appreciated that the spherical portion 51a is a close fit with the spherical recess 52a, thereby maintaining a secure attachment between the first arm 51 and the second arm 52 in the event of a loss of force, and also providing for stable support of the clip 20 and the ablation device 1000 by the support structure 50. For example, the second arm 52 is hinged to the third arm 53, thereby adjusting the angle between the second arm 52 and the third arm 53. For example, a locking knob 56 is provided between the second arm 52 and the third arm 53, and after the angle between the second arm 52 and the third arm 53 is adjusted, the second arm 52 and the third arm 53 can be fixed by screwing the locking knob 56. For example, one of the third arm 53 and the fourth arm 54 includes a spherical portion and the other includes a spherical recess such that the third arm 53 and the fourth arm 54 are rotatably coupled. For example, the structure and material of the connection between the third arm 53 and the fourth arm 54 may be identical to the structure and material of the connection between the first arm 51 and the second arm 52. In this way, the support structure 50 with the multi-arm structure can flexibly adjust the position and direction of the ablation device 1000 according to the needs of the operator, so that the operator can conveniently perform the ablation operation for a long time.

As shown in connection with fig. 1-22, in treating benign prostatic hyperplasia using the ablation system described above, the support structure 50 is secured to the console 60 by the bedside clip 55, and the clamp 20 holding the ablation device 1000 is secured to the end of the support structure 50 remote from the console 60. By adjusting the angles between the first arm 51, the second arm 52, the third arm 53, and the fourth arm 54 in the bracket structure 50, the orientation and position of the guide 400, the ablation needle catheter 220, and the endoscope catheter 500 in the ablation device 1000 are adjusted. The endoscope passes through the housing 100 of the ablation device 1000 and enters the endoscope catheter 500, the wire outlet hole 130 on the housing can lead out the cable in the ablation device 1000 and is electrically connected with the ablation host 10, and the wire outlet hole 130 can also be used for passing through the liquid inlet pipe and the liquid outlet pipe of the infusion pipe to realize the inflow or outflow of liquid.

For example, during ablation, the guide 400 and outer tube 550 are advanced from the urethra while pressing the first pusher 710 closes the first switch 720, causing a fluid, such as saline, to irrigate the urethra. During this process, the needle body 210 is housed within the guide 400 and the ablation needle catheter 220. After the endoscope observes that the guide 400 reaches the position to be ablated, the first switch 720 is pushed to slide relative to the housing 100 to close the second switch 730, and the driving mechanism 300 drives the ablation portion 212 of the needle body 210 to extend out of the second opening 410 to puncture the urethra to reach the hyperplasia tissue of the prostate. After the ablation portion 212 of the needle body 210 penetrates into the hyperplastic tissue, the ablation pedal 40 is depressed to generate an electric field at the ablation portion 212, and the high-voltage pulse electric field is applied to the hyperplastic tissue to cause irreversible electroporation of tissue cell membranes to undergo apoptosis.

After one ablation operation is completed, the second pressing piece 810 is pressed to close the third switch, and the driving mechanism 300 generates a reverse magnetic force to drive the needle body 210 to retract into the guide 400. Whether the next treatment is needed is judged according to the position and the size of the proliferation tissue, and if the next treatment is not needed, the ablation device 1000 is withdrawn from the urethra, and the ablation operation is finished. If the next treatment is required, the angle of each arm in the support structure 50 is adjusted so that the ablation device 1000 reaches the next treatment position, the above operation is repeated, and the hyperplastic tissues at other positions are ablated until the ablation device 1000 is withdrawn from the urethra after the treatment is completed, and the ablation operation is finished. By the ablation device 1000 and the ablation system in at least one embodiment of the present disclosure, the ablation treatment of the benign prostatic hyperplasia tissue can be performed more accurately. In addition, the electric field is generated by the ablation portion 212 of the needle body 210 to ablate the proliferated tissue, so that complications can be minimized, the sexual function of the patient can be maintained, and thermal damage can not be caused. In addition, the duration of the ablation procedure using irreversible electroporation is relatively short, and the use of hormone blocking agents and the like is not required.

According to at least one embodiment of the present disclosure, the operator may also select a single needle structure of the ablation device 1000 or a multiple needle structure of the ablation device 1000 according to the actual condition of the tissue to be proliferated, which is more adaptable.

In addition to the above non-limiting description, the following points are to be described:

(1) In the drawings of the embodiments of the present disclosure, only the structures related to the embodiments of the present disclosure are referred to, and other structures may refer to the general design.

(2) Features of the same and different embodiments of the disclosure may be combined with each other without conflict.

The foregoing is merely exemplary embodiments of the present disclosure and is not intended to limit the scope of the disclosure, which is defined by the appended claims.

Claims

1. An ablation device, comprising:

a housing having a receiving cavity, wherein the receiving cavity has a first opening;

at least one ablation needle, wherein the at least one ablation needle each comprises a needle body;

a driving mechanism located in the accommodating cavity and configured to drive at least one needle body to move along the extending direction of the axis of the first opening,

wherein the needle body of the ablation needle comprises a connecting part and an ablation part; the connecting part is in transmission connection with the driving mechanism and at least partially extends out of the accommodating cavity from the first opening; the ablation part is connected to one end of the connection part far away from the driving mechanism and is configured to generate an electric field;

The drive mechanism is further configured to drive the needle body of the at least one ablation needle to an ablation position such that all of the plurality of ablation portions are aligned along the direction of extension of the axis when all of the needle body is in the ablation position and the at least one ablation needle comprises a plurality of ablation needles.

2. The ablation device of claim 1, wherein when the needle bodies of the plurality of ablation needles are all in the ablation position, the ablation portions of the needle bodies of the plurality of ablation needles are on a straight line parallel to the axis away from a center point of an end of the corresponding connection portion.

3. The ablation device of claim 1 or 2, wherein the connecting portion of the at least one ablation needle is parallel to the axis; the ablation portion of the at least one ablation needle is configured to intersect the corresponding connection portion when the needle body of the at least one ablation needle is in the ablation position.

4. The ablation device of claim 3, further comprising a guide, wherein the at least one ablation needle each further comprises an ablation needle catheter;

the ablation needle guide tube of the at least one ablation needle is sleeved outside the corresponding needle body and is connected with the shell; the guide piece is sleeved outside one end, far away from the shell, of the ablation needle catheter of the at least one ablation needle, and a second opening is formed in the guide piece;

The ablation portion is configured to protrude from the second opening when the needle body of the at least one ablation needle is in the ablation position.

5. The ablation device of claim 4, wherein the guide is provided with a guide portion that guides deformation of the needle body of the at least one ablation needle;

the guiding part is provided with a first opening, a second opening and a guiding part, wherein the first opening is provided with a first opening, the second opening is provided with a second opening, the guiding part is provided with a starting end, the end, close to the housing, of the guiding part is provided with a tail end, and the direction from the starting end to the tail end is arranged at an angle with the extending direction of the axis.

6. The ablation device of claim 5, wherein the guide comprises a guide portion and a notch portion;

the notch portion is located on a side of the guide portion near the housing in an extending direction of the axis, and is configured to expose a portion of the needle body when the needle body enters the guide.

7. The ablation device of claim 6, wherein a cross-sectional shape of the guide portion taken by a plane parallel to a plane of the second opening has an arcuate boundary;

the arc of the arc boundary is greater than pi.

8. The ablation device of claim 1 or 2, wherein the needle body comprises an insulating surface and an electrode structure;

The insulation surface is positioned on the ablation part, the electrode structure comprises a first electrode part and a second electrode part, and the first electrode part and the second electrode part are arranged on the insulation surface at intervals along the extending direction of the needle body;

the electrode structure is configured to generate an electric field between the first electrode portion and the second electrode portion when electrically conductive.

9. The ablation device of claim 1 or 2, wherein the ablation portion comprises an adjacent insulating region and a conductive region, the conductive region being located at an end of the ablation portion remote from the connection portion;

the at least one ablation needle includes a plurality of ablation needles, the ablation portions of the plurality of ablation needles configured to form an electric field between adjacent two of the conductive regions when electrically conductive.

10. The ablation device of claim 1 or 2, further comprising an endoscopic catheter and a return member disposed within said receiving cavity,

the central line of the endoscope catheter is parallel to the axis, the reflux member comprises a reflux cavity and a sealing member, and the sealing member is arranged at one side, far away from the endoscope catheter, of the reflux cavity;

The flashback chamber is in communication with the endoscope conduit and is configured to allow liquid to circulate between the flashback chamber and the endoscope conduit.

11. The ablation device of claim 10, wherein the seal tapers in size from a side distal to the endoscope conduit to a side proximal to the endoscope conduit in a direction perpendicular to the axis.

12. The ablation device of claim 10, wherein the drive mechanism comprises a magnet assembly slidably disposed about the endoscope catheter and coupled to the needle body, and a coil disposed about the magnet assembly;

the coil is configured to generate a magnetic force to drive the magnet assembly to move along an extension direction of the axis when electrically conductive.

13. The ablation device of claim 12, wherein the drive mechanism includes a coil mounting member coupled to the housing, the coil being wound outside the coil mounting member;

the magnet assembly comprises a magnet mounting member and a magnet, the magnet is sleeved outside the magnet mounting member, the needle body is connected with the magnet mounting member, and the magnet mounting member is arranged between the endoscope catheter and the coil mounting member;

A dimension of the coil mounting member in an extending direction of the axis is larger than a dimension of the magnet mounting member in the extending direction of the axis;

one end of the coil mounting member, which is away from the first opening in the extending direction of the axis, is provided with a limiting portion that partially overlaps the magnet in the extending direction of the axis.

14. The ablation device of claim 13, wherein the magnet mounting member comprises a first stop, a connecting portion, and a second stop connected in sequence, the magnet being stopped between the first stop and the second stop;

the first stop part is positioned at one side close to the first opening; the second stopper portion does not overlap the limit portion in the extending direction of the axis, and is located on one side of the center line of the magnet mounting member.

15. The ablation device of any of claims 11-14, further comprising a first switching mechanism comprising a first pusher and a first switch positioned within the containment chamber and configured to be in operative connection with an ablation host;

the first pressing piece is configured to press against the first switch to close the first switch when the first pressing piece is acted on, so that the ablation host receives a control signal to control liquid to flow into the reflux cavity and the endoscope catheter.

16. The ablation device of claim 15, wherein the first switch is further configured to slide relative to the housing in a direction of extension of the axis when acted upon;

the first switch mechanism further includes a second switch configured to close against the second switch during sliding to control the drive mechanism to drive the connection portion to move in an extending direction of the axis to the needle body in the ablation position.

17. The ablation device of claim 16, wherein the first switch mechanism further comprises a resilient member;

the elastic member is connected between the first switch and the housing and configured to apply an elastic force separating the first switch and the second switch from each other.

18. The ablation device of claim 15, further comprising a second switch mechanism, wherein the second switch mechanism comprises a second pusher and a third switch, the third switch being positioned within the containment chamber and electrically connected to the drive mechanism;

the second pressing piece is configured to close the third switch against the third switch when acted, so that the driving mechanism drives one end of the connecting part away from the ablation part to move away from the first opening along the extending direction of the axis.

19. An ablation system comprising the ablation device of any one of claims 15-18 and the ablation host.

20. The ablation system of claim 19, further comprising a clamp, wherein the clamp comprises a slip fit first portion and a second portion, the first portion and the second portion configured to have a clamping position during relative sliding;

the shell comprises a shell main body and a mounting part which are connected with each other, and the first opening is positioned at one side of the mounting part away from the shell main body;

the first portion includes a first clamping surface and the second portion includes a second clamping surface;

the first portion and the second portion are configured to form a clamping space between the first clamping surface and the second clamping surface for clamping the mounting portion when in the clamping position.

21. The ablation system of claim 20, further comprising a connector, wherein a side of the first portion facing the second portion is provided with a first ramp and a side of the second portion facing the first portion is provided with a second ramp; the extending directions of the first slide rail and the second slide rail are parallel to the extending direction of the axis;

The connecting piece comprises a first end and a second end which are oppositely arranged in a first direction, and the first direction is perpendicular to the extending direction of the axis; the first end is in sliding fit with the first slide, and the second end is in sliding fit with the second slide.

22. The ablation system of claim 20, wherein the first portion comprises a first support surface and the second portion comprises a second support surface; the first support surface and the second support surface are configured to collectively support the housing body;

at least one of the first support surface and the second support surface is configured to interfit in shape with a surface of the housing body.