CN117534294A - Preparation process of borosilicate glass medicament bottle - Google Patents
Preparation process of borosilicate glass medicament bottle Download PDFInfo
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- CN117534294A CN117534294A CN202410024553.4A CN202410024553A CN117534294A CN 117534294 A CN117534294 A CN 117534294A CN 202410024553 A CN202410024553 A CN 202410024553A CN 117534294 A CN117534294 A CN 117534294A
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- 239000003814 drug Substances 0.000 title claims abstract description 92
- 239000005388 borosilicate glass Substances 0.000 title claims abstract description 77
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000011521 glass Substances 0.000 claims abstract description 54
- 238000010438 heat treatment Methods 0.000 claims abstract description 45
- 238000004519 manufacturing process Methods 0.000 claims abstract description 32
- 238000007493 shaping process Methods 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 230000000704 physical effect Effects 0.000 claims abstract description 16
- 239000003086 colorant Substances 0.000 claims abstract description 12
- 238000004040 coloring Methods 0.000 claims abstract description 10
- 238000001816 cooling Methods 0.000 claims abstract description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 18
- 238000001514 detection method Methods 0.000 claims description 18
- 230000007797 corrosion Effects 0.000 claims description 10
- 238000005260 corrosion Methods 0.000 claims description 10
- 238000002844 melting Methods 0.000 claims description 10
- 230000008018 melting Effects 0.000 claims description 10
- 238000010309 melting process Methods 0.000 claims description 10
- 239000002105 nanoparticle Substances 0.000 claims description 10
- 238000010791 quenching Methods 0.000 claims description 10
- 230000000171 quenching effect Effects 0.000 claims description 10
- 238000000137 annealing Methods 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 238000009489 vacuum treatment Methods 0.000 claims description 9
- 239000000377 silicon dioxide Substances 0.000 claims description 7
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 5
- 239000004446 fluoropolymer coating Substances 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 17
- 230000008569 process Effects 0.000 abstract description 11
- 238000012545 processing Methods 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 4
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 28
- 230000006872 improvement Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000156 glass melt Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
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- 238000012360 testing method Methods 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B5/00—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture
- C03B5/16—Special features of the melting process; Auxiliary means specially adapted for glass-melting furnaces
- C03B5/23—Cooling the molten glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B25/00—Annealing glass products
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B27/00—Tempering or quenching glass products
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B5/00—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture
- C03B5/16—Special features of the melting process; Auxiliary means specially adapted for glass-melting furnaces
- C03B5/18—Stirring devices; Homogenisation
- C03B5/183—Stirring devices; Homogenisation using thermal means, e.g. for creating convection currents
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C1/00—Ingredients generally applicable to manufacture of glasses, glazes, or vitreous enamels
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C17/00—Surface treatment of glass, not in the form of fibres or filaments, by coating
- C03C17/001—General methods for coating; Devices therefor
- C03C17/003—General methods for coating; Devices therefor for hollow ware, e.g. containers
- C03C17/005—Coating the outside
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C17/00—Surface treatment of glass, not in the form of fibres or filaments, by coating
- C03C17/28—Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to the technical field of glass product processing, and discloses a preparation process of a borosilicate glass medicament bottle, wherein S1, a middle borosilicate glass raw material is melted to obtain molten middle borosilicate glass; s2, cooling the molten medium borosilicate glass to a temperature suitable for shaping; s3, shaping the cooled medium borosilicate glass into a preliminary shape of a medicament bottle by using a die; s4, performing heat treatment on the initially shaped medicament bottle to improve the physical properties of the medicament bottle; s5, coloring the exterior of the heat-treated medicament bottle with a brown colorant. The traditional borosilicate glass preparation process has the problems of low production efficiency and high cost, which limits the wide application of the borosilicate glass. However, the production efficiency is obviously improved and the production cost is effectively reduced by optimizing the process flow and introducing new technology. This will enable manufacturers to more efficiently produce borosilicate glass pharmaceutical vials, further enhancing market competitiveness.
Description
Technical Field
The invention relates to the technical field of glass product processing, in particular to a preparation process of a borosilicate glass medicament bottle.
Background
Borosilicate glass medicament bottle as an important packaging material has wide application in medicine and chemical industry fields. However, the conventional borosilicate glass preparation process has some limitations, which limit its wide application.
First, the conventional borosilicate glass preparation process may have a problem of low production efficiency. In the conventional process, the melting and forming of borosilicate glass requires multiple steps, and each step requires strict control of temperature, time and composition. This not only increases the production cost but also reduces the production efficiency. Therefore, the conventional borosilicate glass preparation process has a certain limitation in terms of production efficiency.
Secondly, the traditional borosilicate glass preparation process has higher cost. The conventional borosilicate glass preparation process requires a large amount of raw materials and energy, and strict quality control and detection are required in the production process, so that the cost is relatively high. This limits the use of borosilicate glass medicament vials in a wider range of fields.
Furthermore, conventional borosilicate glass medicament vials have limitations in color selection. In the traditional process, the selection of the color of the product is limited, and the market requirement for various colors cannot be met. This has limited the use of borosilicate glass vials in certain particular fields.
Finally, conventional borosilicate glass has certain limitations in terms of strength and transparency. Although borosilicate glass has higher strength and clarity, conventional borosilicate glass may not be satisfactory in certain applications, such as where higher strength or higher clarity is desired.
Therefore, the invention provides a preparation process of borosilicate glass medicament, which solves the defects in the prior art.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a preparation process of the borosilicate glass medicament bottle, overcomes the limitations by optimizing the process flow and introducing new technology, realizes the improvement of production efficiency, the diversification of color selection, the enhancement of product strength and transparency and the improvement of heat resistance and corrosion resistance, and brings remarkable technical progress and commercial advantages for the preparation of the borosilicate glass medicament bottle.
In order to achieve the above purpose, the invention is realized by the following technical scheme: a preparation process of borosilicate glass medicament bottles comprises the following steps:
s1, melting a medium borosilicate glass raw material to obtain molten medium borosilicate glass;
s2, cooling the molten medium borosilicate glass to a temperature suitable for shaping;
s3, shaping the cooled medium borosilicate glass into a preliminary shape of a medicament bottle by using a die;
s4, performing heat treatment on the initially shaped medicament bottle to improve the physical properties of the medicament bottle;
s5, coloring the exterior of the heat-treated medicament bottle with a brown colorant;
s6, performing secondary heat treatment on the colored medicament bottle to stabilize the color and physical properties of the medicament bottle;
and S7, detecting the quality of the medicament bottle subjected to the final heat treatment to obtain a qualified product.
Preferably, the components of the colorant are cobalt powder and manganese powder.
Preferably, the heat treatment step includes annealing and quenching to improve strength and heat resistance of the pharmaceutical vial.
Preferably, 1-5% of silica nanoparticles are added to the molten mesoborosilicate glass to enhance the strength and transparency of the glass.
Preferably, the medium borosilicate glass raw material is subjected to vacuum treatment in the melting process so as to remove bubbles and impurities.
Preferably, the molten mesoborosilicate glass is cooled to a temperature suitable for shaping in the range 600 ℃ to 800 ℃.
Preferably, the mold is a metal mold or a silicone mold having a shape of a medicine bottle.
Preferably, the quality detection includes detection of appearance quality, dimensional accuracy and heat resistance of the medicament bottle.
Preferably, the heating device adopted in the melting process is a resistance heating furnace.
Preferably, the surface of the medicament bottle is coated with a fluoropolymer coating, so that the medicament bottle has acid and alkali corrosion resistance.
The invention provides a preparation process of a borosilicate glass medicament bottle. The beneficial effects are as follows:
1. the traditional borosilicate glass preparation process has the problems of low production efficiency and high cost, which limits the wide application of the borosilicate glass. However, the production efficiency is obviously improved and the production cost is effectively reduced by optimizing the process flow and introducing new technology. This will enable manufacturers to more efficiently produce borosilicate glass pharmaceutical vials, further enhancing market competitiveness;
2. while the traditional borosilicate glass medicament bottle has limitation on color selection, the innovation of the invention is that brown coloring treatment is introduced, so that the color diversity of products is realized. The improvement meets the demands of different color medicament bottles in the market, thereby improving the market adaptability and competitiveness of the product;
3. conventional borosilicate glass has certain limitations in terms of strength and transparency. In order to solve this problem, the present invention achieves enhanced strength and transparency of the pharmaceutical vial by adding silica nanoparticles to the glass and performing a heat treatment. The improvement can improve the quality and the reliability of the product, so that the medicament bottle is more suitable for various application scenes;
4. conventional borosilicate glass medicament bottles have certain limitations in heat resistance and corrosion resistance. However, by the heat treatment and coating treatment techniques of the present invention, the heat resistance and corrosion resistance of the pharmaceutical vials are significantly improved. This will further expand the range of applications of the product making it more suitable for various harsh industrial environments. Meanwhile, the improvement also obviously improves the practicability and durability of the product, and provides more reliable and efficient product experience for users.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention provides a preparation process of borosilicate glass medicament bottles, which comprises the following steps:
s1, melting a medium borosilicate glass raw material to obtain molten medium borosilicate glass:
the step is to heat the medium borosilicate glass raw material to a temperature above the melting point of the medium borosilicate glass raw material, so that the medium borosilicate glass raw material is completely or partially melted into glass liquid in a flowing state. The method has the advantages that raw materials can be fully mixed, bubbles are removed, and uniformity and stability of glass are ensured.
S2, cooling the molten medium borosilicate glass to a temperature suitable for shaping:
at this stage, the molten glass needs to be cooled to a suitable temperature for the subsequent shaping process. This helps ensure good plasticity and formability of the glass during shaping while avoiding cracking or stress formation of the glass due to excessive cooling.
S3, shaping the cooled mesoborosilicate glass into the preliminary shape of a medicament bottle by using a die:
this step is to mold the cooled glass into a preliminary shape of a medicament bottle through a mold. The overall dimension and the shape of the medicine bottle can be ensured to meet the design requirement through the mould shaping, and meanwhile, the production efficiency can be improved.
S4, performing heat treatment on the initially shaped medicament bottle to improve the physical properties of the medicament bottle:
the heat treatment is to control the temperature and time of the glass to crystallize, change phase or release stress, so as to raise the physical performance, such as strength, heat resistance, etc. This can enhance the durability and stability of the vial.
S5, coloring the exterior of the heat-treated medicament bottle with a brown colorant:
the coloring treatment can endow the medicine bottle with specific color, and can improve the ultraviolet resistance and chemical stability of the glass surface. In addition, the appropriate coloring can also reduce the photosensitivity of the transparent glass to the medicines and protect the medicines from light.
S6, performing secondary heat treatment on the colored medicament bottle to stabilize the color and physical properties of the medicament bottle:
the secondary heat treatment is helpful for stabilizing the distribution of the coloring agent and improving the adhesive force of the coloring agent, and can further improve the physical properties of the glass and ensure the stable quality of the product.
S7, detecting the quality of the medicament bottle subjected to the final heat treatment to obtain a qualified product:
quality inspection is the inspection of a product at various stages of the process to ensure that the product meets relevant standards and specifications. The qualified product can ensure the safety and reliability of the product and improve the satisfaction degree of clients.
The improvement of the steps can improve the production efficiency, reduce the cost, enhance the performance and stability of the product, enrich the color selection of the product and provide a qualified final product.
The coloring agent comprises cobalt powder and manganese powder.
By adding a proper amount of cobalt powder and manganese powder, the medicine bottle can be blue or purple, so that more color choices can be provided for products, and the requirements of different customers are met.
Meanwhile, the addition of the cobalt powder and the manganese powder can also enhance the ultraviolet resistance and chemical stability of the glass, and is helpful for protecting the medicines from light and environmental factors.
The heat treatment step includes annealing and quenching to improve strength and heat resistance of the pharmaceutical vial.
Annealing: annealing is performed by controlling the temperature and time of the glass to cool it slowly to a lower temperature to relieve stress within the glass while increasing its toughness and heat resistance. By annealing, the internal structure of the glass can be adjusted, thereby improving the overall performance.
Quenching: quenching is the sudden cooling of the glass to a lower temperature to rapidly solidify the glass and increase its hardness. Quenching can form a layer of compressive stress on the surface of the glass, thereby improving its resistance to compression and abrasion. However, quenching also causes internal stresses in the glass, and it is therefore often necessary to carry out an annealing treatment after quenching to relieve these stresses.
Through reasonable annealing and quenching processes, the physical properties of the glass can be improved, and the strength, the heat resistance and the wear resistance of the glass can be improved, so that the quality and the reliability of the medicament bottle can be improved.
1-5% of silica nanoparticles are added to the molten medium borosilicate glass to enhance the strength and transparency of the glass.
The addition of 1-5% silica nanoparticles to medium borosilicate glass can have the following effects:
strength enhancement: the addition of the nano particles can form a reinforced network structure in the glass, and effectively prevent crack growth, so that the bending resistance and the impact resistance of the glass are improved. This strengthening effect can make the glass more durable and reduce breakage and damage during use.
Transparency improvement: the nanoparticles are much smaller in size than the wavelength of visible light so they do not cause scattering of visible light, thereby improving the transparency of the glass. This is important for applications requiring transparency, such as pharmaceutical bottles, because it ensures that the user can clearly see the pharmaceutical in the bottle, while also contributing to the aesthetic appearance of the product.
By adding the silicon dioxide nano particles, the mesoborosilicate glass has more excellent performance, and the applicability and the competitiveness of the mesoborosilicate glass in the application of medicament bottles and the like are improved.
Vacuum treatment is carried out on the medium borosilicate glass raw material in the melting process so as to remove bubbles and impurities.
The vacuum treatment generally comprises the steps of:
vacuum pumping: in the glass melting process, a vacuum environment is established in the melting furnace, and air and gas in the furnace are pumped out by using equipment such as a vacuum pump, so that the solubility of the gas is reduced, and bubbles are promoted to escape from glass melt.
Removing bubbles: in the vacuum treatment process, bubbles in the molten glass raw material gradually rise and escape from the molten glass, so that the bubble content in the final glass product is reduced, and the transparency and uniformity of the glass are improved.
Removing impurities: vacuum treatment also helps to remove impurities from the glass raw material because certain volatile impurities can be more easily vaporized and removed under vacuum conditions, thereby reducing the effect of the impurities on the properties of the glass article.
The quality and the appearance of the glass product can be effectively improved through vacuum treatment, the adverse effect of bubbles and impurities on the glass performance is reduced, and the final product is ensured to meet the quality standard. Appropriate vacuum processing parameters need to be determined according to the specific glass formulation and production process to ensure a balance of processing efficiency and production efficiency.
The molten medium borosilicate glass is cooled to a temperature of 600 ℃ to 800 ℃ suitable for shaping.
The mold is a metal mold or a silica gel mold with the shape of a medicament bottle.
And (3) a metal mold: the metal mold is typically made of a high temperature resistant metal such as stainless steel or an aluminum alloy. They can maintain shape stability at high temperatures and can be used for the shaping of high temperature glass melts. The metal mold is suitable for mass production, can bear high pressure and high temperature, and has longer service life.
And (3) a silica gel mold: silicone molds are typically made of silicone rubber, with good flexibility and high temperature resistance. Silica gel molds are suitable for small volume production or product manufacturing requiring complex details because they can more easily achieve complex shapes and details and provide better release properties to the glass melt.
The quality detection comprises detection of appearance quality, dimensional accuracy and heat resistance of the medicament bottle.
The following are methods for quality detection:
appearance quality detection: appearance quality detection may include detection of flatness, transparency, freedom from bubbles and imperfections of the surface of the vial. This can be done by visual inspection and optical microscopy. In addition, an automated optical inspection system may be used to detect surface defects.
And (3) dimensional accuracy detection: dimensional accuracy detection can be performed by using a three-coordinate measuring machine or other precise measuring equipment so as to ensure that the dimensions of the diameter, the height, the wall thickness and the like of the medicament bottle meet the design requirements.
And (3) heat resistance detection: the heat resistance test can be evaluated by placing the vial in a hot box or performing a thermal shock test. This can be used to verify the stability and heat resistance of the vial in high temperature environments.
Besides the detection methods, the chemical stability, the compressive property and the like of the medicament bottle can be detected so as to ensure that the medicament bottle meets the requirements of medicament packaging.
The heating equipment adopted in the melting process is a resistance heating furnace.
The following features and working principles of the resistance heating furnace are as follows:
heating principle: the resistance heating furnace generates resistance heating effect by using resistance wires, and converts electric energy into heat energy. The resistance wire is generally made of a high-temperature resistant alloy material, and is capable of stably operating at a high temperature. When an electric current is passed through the resistance wire, the resistance wire generates heat, thereby heating the surrounding glass raw material to a melting temperature.
And (3) temperature control: the resistance heating furnace is generally equipped with a temperature control system, and the temperature inside the heating furnace can be precisely controlled. This helps to ensure that the glass raw material can be melted in a suitable temperature range while avoiding overheating or insufficient temperature.
Uniformity of heating: the resistance heating furnace can provide relatively uniform heating, ensures that the glass raw materials are uniformly heated in the melting process, and is beneficial to producing high-quality glass products.
Control flexibility: the temperature and the heating process in the furnace can be flexibly controlled by adjusting the current and the heating time so as to meet the processing requirements of different glass materials.
In the case of a glass melting process using a resistance heating furnace, attention is paid to the stability of the temperature in the furnace, the heating uniformity and the safety to ensure that a satisfactory glass product is produced.
The surface of the medicament bottle is coated with a fluoropolymer coating, so that the medicament bottle has acid and alkali corrosion resistance.
Embodiment one: the method comprises the following specific steps:
s1, adding a medium borosilicate glass raw material into a resistance heating furnace for melting to obtain molten medium borosilicate glass;
s2, cooling the molten medium borosilicate glass to a temperature (about 700 ℃) suitable for shaping;
s3, molding the cooled mesoborosilicate glass into the initial shape of the medicament bottle by using a metal mold;
s4, annealing and quenching the initially molded medicament bottle, so that the physical properties and heat resistance of the medicament bottle are improved;
s5, externally coating a fluoropolymer coating to enable the fluoropolymer coating to have acid and alkali corrosion resistance;
s6, quality detection is carried out, and qualified products are obtained;
the preparation process improves the production efficiency and reduces the production cost by optimizing melting, shaping, heat treatment and coating treatment, and simultaneously ensures that the medicament bottle has acid and alkali corrosion resistance.
Embodiment two: the method comprises the following specific steps:
s1, adding 1-5% of silicon dioxide nano particles into the medium borosilicate glass in the melting process so as to enhance the strength and transparency of the glass;
s2, cooling the molten medium borosilicate glass to a temperature (about 650 ℃) suitable for shaping;
s3, shaping the cooled mesoborosilicate glass into a preliminary shape of a medicament bottle by using a silica gel mold;
s4, performing heat treatment on the initially shaped medicament bottle to ensure that the medicament bottle has excellent physical properties;
s5, performing brown colorant treatment and secondary heat treatment, and stabilizing the color and physical properties of the medicament bottle;
s6, quality detection is carried out, and qualified products are obtained;
the process enables the medicament bottle to have enhanced strength and transparency and stable color through adding nano particles, heat treatment and coloring treatment.
Embodiment III: the method comprises the following specific steps:
s1, melting a borosilicate glass raw material and performing vacuum treatment to remove bubbles and impurities;
s2, cooling the molten medium borosilicate glass to a temperature (about 750 ℃) suitable for shaping;
s3, molding the cooled mesoborosilicate glass into the initial shape of the medicament bottle by using a metal mold;
s4, performing heat treatment on the initially shaped medicament bottle to improve the physical properties of the medicament bottle;
s5, performing brown colorant treatment and secondary heat treatment, and stabilizing the color and physical properties of the medicament bottle;
s6, quality detection is carried out, and qualified products are obtained;
the borosilicate glass medicament bottle with high quality and stability is prepared by vacuum treatment, shaping, heat treatment and coloring treatment.
All three examples show different process paths for preparing borosilicate glass medicament bottles to meet different performance requirements. By optimizing the process flow and introducing new technology, the production efficiency is improved, and the production cost is reduced. Meanwhile, brown coloring treatment is introduced, so that the color of the medium borosilicate glass medicament bottle is diversified, and the market demand is met.
Comparison experiment and data table:
in the comparative experiments, the physical properties, heat resistance and corrosion resistance of the vial samples of the three examples were respectively tested, and data tables were made to exhibit the respective advantages.
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By comparing the tables of experimental data, it can be seen that each of the examples has advantages in different aspects, for example, the second example has very excellent physical properties, the third example has very high heat resistance, and the first example has good corrosion resistance.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The preparation process of the borosilicate glass medicament bottle is characterized by comprising the following steps of:
s1, melting a medium borosilicate glass raw material to obtain molten medium borosilicate glass;
s2, cooling the molten medium borosilicate glass to a temperature suitable for shaping;
s3, shaping the cooled medium borosilicate glass into a preliminary shape of a medicament bottle by using a die;
s4, performing heat treatment on the initially shaped medicament bottle to improve the physical properties of the medicament bottle;
s5, coloring the exterior of the heat-treated medicament bottle with a brown colorant;
s6, performing secondary heat treatment on the colored medicament bottle to stabilize the color and physical properties of the medicament bottle;
and S7, detecting the quality of the medicament bottle subjected to the final heat treatment to obtain a qualified product.
2. The process for preparing a borosilicate glass medicament bottle as claimed in claim 1, wherein the components of the colorant are cobalt powder and manganese powder.
3. The process for preparing a borosilicate glass medical bottle as claimed in claim 1, wherein said heat treatment step comprises annealing and quenching to improve strength and heat resistance of the medical bottle.
4. The process for preparing a borosilicate glass medicament bottle as claimed in claim 1, wherein 1-5% of silica nanoparticles are added to the molten medium borosilicate glass to enhance the strength and transparency of the glass.
5. The process for preparing a borosilicate glass medicament bottle as defined in claim 1, wherein the borosilicate glass raw material is subjected to vacuum treatment during the melting process to remove bubbles and impurities.
6. The process for preparing a borosilicate glass pharmaceutical vial according to claim 1, wherein said molten mesoborosilicate glass is cooled to a temperature suitable for shaping in the range of 600 ℃ to 800 ℃.
7. The process for preparing a borosilicate glass medicament bottle according to claim 1, wherein the mold is a metal mold or a silicone mold having a medicament bottle shape.
8. The process for preparing a borosilicate glass medicament bottle according to claim 1, wherein the quality detection comprises detection of appearance quality, dimensional accuracy and heat resistance of the medicament bottle.
9. The process for preparing a borosilicate glass medicament bottle as defined in claim 1, wherein the heating equipment adopted in the melting process is a resistance heating furnace.
10. The process for preparing a borosilicate glass medicament bottle as claimed in claim 1, wherein the surface of the medicament bottle is coated with a fluoropolymer coating to provide the medicament bottle with acid and alkali corrosion resistance.
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