CN117531239A - Bioactive substance extraction control method and system - Google Patents
Bioactive substance extraction control method and system Download PDFInfo
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- CN117531239A CN117531239A CN202410036022.7A CN202410036022A CN117531239A CN 117531239 A CN117531239 A CN 117531239A CN 202410036022 A CN202410036022 A CN 202410036022A CN 117531239 A CN117531239 A CN 117531239A
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- 230000000975 bioactive effect Effects 0.000 title claims abstract description 173
- 239000000126 substance Substances 0.000 title claims abstract description 172
- 238000000605 extraction Methods 0.000 title claims abstract description 102
- 238000000034 method Methods 0.000 title claims abstract description 29
- 239000000243 solution Substances 0.000 claims abstract description 162
- 239000011259 mixed solution Substances 0.000 claims abstract description 11
- 238000013441 quality evaluation Methods 0.000 claims description 48
- 239000011521 glass Substances 0.000 claims description 43
- 238000012544 monitoring process Methods 0.000 claims description 20
- 238000009210 therapy by ultrasound Methods 0.000 claims description 14
- 238000011156 evaluation Methods 0.000 claims description 5
- 230000009471 action Effects 0.000 abstract description 2
- 230000001276 controlling effect Effects 0.000 description 18
- 230000000694 effects Effects 0.000 description 14
- 238000001303 quality assessment method Methods 0.000 description 14
- 229940088623 biologically active substance Drugs 0.000 description 8
- 238000002604 ultrasonography Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 239000005356 container glass Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 210000003855 cell nucleus Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0261—Solvent extraction of solids comprising vibrating mechanisms, e.g. mechanical, acoustical
- B01D11/0265—Applying ultrasound
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Abstract
The invention provides a method and a system for controlling extraction of bioactive substances. The bioactive substance extraction control method comprises the following steps: extracting the whole surface area and filling information of an ultrasonic vibration container corresponding to the target solution of the current bioactive substance; determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area of the ultrasonic vibration container and the filling information; and controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy, and obtaining the mixed solution with the bioactive substances. The system comprises modules corresponding to the method steps. By determining the parameters of ultrasonic vibration according to the surface area and the filling information of the container, the action range and the intensity of ultrasonic waves can be controlled more accurately, so that the extraction efficiency of bioactive substances is improved.
Description
Technical Field
The invention provides a method and a system for controlling extraction of bioactive substances, and belongs to the technical field of control of biological extraction systems.
Background
With the rapid development of biotechnology, bioactive substances are increasingly used in the fields of medical treatment, pharmacy, food, agriculture and the like. Methods of extracting bioactive substances are also continually improving to achieve higher extraction efficiencies and purities. Ultrasonic technology is widely used in the extraction process of bioactive substances as a high-efficiency and nondestructive extraction method. However, during high frequency ultrasonic (e.g., 100 kHz) treatment, long-term ultrasonic treatment may cause loss of the container, resulting in a reduction in the service life of the glass, which is a problem to be solved.
Disclosure of Invention
The invention provides a method and a system for controlling extraction of bioactive substances, which are used for solving the problem that the service life of glass is reduced because long-term ultrasonic treatment can generate loss on a container in the high-frequency ultrasonic (such as 100 kHz) treatment process:
a bioactive substance extraction control method, the bioactive substance extraction control method comprising:
extracting the whole surface area and filling information of an ultrasonic vibration container corresponding to the target solution of the current bioactive substance;
determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area of the ultrasonic vibration container and the filling information;
and controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy, and obtaining the mixed solution with the bioactive substances.
Further, extracting the whole surface area and the filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance, wherein the method comprises the following steps:
monitoring whether the ultrasonic vibration container is filled with the target solution in real time;
when the ultrasonic vibration container finishes filling of the target solution, acquiring the current filling volume of the target solution;
the entire surface area of the glass of the current ultrasonically-vibrated container is extracted from the database.
Further, determining an upper limit value of ultrasonic vibration frequency and a vibration strategy of the bioactive substance according to the whole surface area and the filling information of the ultrasonic vibration container, comprising:
acquiring a container quality evaluation parameter by utilizing the whole surface area of the glass of the current ultrasonic vibration container;
extracting a vibration frequency range of a target solution corresponding to the current bioactive substances from a database;
and determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substances of the target solution corresponding to the current bioactive substances according to the container quality evaluation parameters.
Further, the container quality evaluation parameters are obtained by the following formula:
wherein,Erepresenting a container quality assessment parameter;nrepresenting the total number of extractions of the biologically active substance using ultrasound;F i represent the firstiThe maximum pressure of the ultrasonic wave acting on the glass of the ultrasonic vibration container;S i represent the firstiThe ultrasonic wave of the secondary ultrasonic wave acts on the average stress surface of the glass of the ultrasonic vibration container;Vrepresent the firstiThe volume of solution in the ultrasonic vibration container in the extraction of the secondary bioactive substances;Vrepresenting the container volume of the ultrasonically vibrated container;Pthe sound pressure of the ultrasonic wave;ωthe vibration angular frequency of the ultrasonic wave is represented; tan (tan)δRepresents the dielectric loss tangent;Srepresenting the overall surface area of the ultrasonically vibrated container;S p representing an average stress surface of the glass after the ultrasonic wave corresponding to the total extraction times of the bioactive substances applying the ultrasonic wave is applied to the glass of the ultrasonic vibration container;ρrepresents the average density of the solution;ηindicating the average viscosity of the solution.
Further, determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substance of the target solution corresponding to the current bioactive substance according to the container quality evaluation parameter, wherein the method comprises the following steps:
extracting container quality evaluation parameters corresponding to the current ultrasonic vibration container;
acquiring an ultrasonic vibration frequency upper limit value of the bioactive substance of the target solution corresponding to the current bioactive substance by utilizing the container quality evaluation parameter and the vibration frequency range of the target solution corresponding to the current bioactive substance; wherein, the ultrasonic vibration frequency upper limit value is obtained by the following formula:
wherein,f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;Erepresenting a container quality assessment parameter;E 0 representing a preset parameter threshold;αrepresents a frequency adjustment parameter, and the expression of the frequency adjustment parameter is as follows:
wherein,v m representing the optimal sound velocity for bioactive substance extraction of the target solution;λ m indicating the optimal wavelength for bioactive substance extraction of the target solution;
setting a maximum continuous vibration duration and an intermittent duration limit value of the current ultrasonic vibration through an ultrasonic vibration frequency upper limit value of the bioactive substance, wherein the maximum continuous vibration duration limit value and the intermittent duration are obtained through the following formula:
wherein,T max representing a maximum duration limit;T cmax representing an initial maximum duration limit for the ultrasonically-vibrated container;f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;T z representing the intermittent duration;T cz indicating an initial intermittent duration of the ultrasonically-vibrated container;f m indicating an optimal vibration frequency for bioactive substance extraction of the target solution;
and controlling the ultrasonic waves to carry out intermittent ultrasonic treatment on the target solution in the ultrasonic vibration container according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
A bioactive substance extraction control system, the bioactive substance extraction control system comprising:
the information extraction module is used for extracting the whole surface area and the filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance;
the strategy setting module is used for determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area and the filling information of the ultrasonic vibration container;
and the system control module is used for controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy and obtaining the mixed solution with the bioactive substances.
Further, the information extraction module includes:
the real-time monitoring module is used for monitoring whether the ultrasonic vibration container is filled with the target solution in real time;
the volume information acquisition module is used for acquiring the current filling volume of the target solution after the ultrasonic vibration container finishes filling of the target solution;
and the glass parameter acquisition module is used for extracting the whole surface area of the glass of the current ultrasonic vibration container from the database.
Further, the policy setting module includes:
the evaluation parameter acquisition module is used for acquiring container quality evaluation parameters by utilizing the whole surface area of the glass of the current ultrasonic vibration container;
the frequency information acquisition module is used for extracting the vibration frequency range of the target solution corresponding to the current bioactive substances from the database;
and the strategy acquisition execution module is used for determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substance of the target solution corresponding to the current bioactive substance according to the container quality evaluation parameter.
Further, the container quality evaluation parameters are obtained by the following formula:
wherein,Erepresenting a container quality assessment parameter;nrepresenting the total number of extractions of the biologically active substance using ultrasound;F i represent the firstiThe maximum pressure of the ultrasonic wave acting on the glass of the ultrasonic vibration container;S i represent the firstiThe ultrasonic wave of the secondary ultrasonic wave acts on the average stress surface of the glass of the ultrasonic vibration container;Vrepresent the firstiThe volume of solution in the ultrasonic vibration container in the extraction of the secondary bioactive substances;Vrepresenting the container volume of the ultrasonically vibrated container;Pthe sound pressure of the ultrasonic wave;ωthe vibration angular frequency of the ultrasonic wave is represented; tan (tan)δRepresents the dielectric loss tangent;Srepresenting the overall surface area of the ultrasonically vibrated container;S p representing an average stress surface of the glass after the ultrasonic wave corresponding to the total extraction times of the bioactive substances applying the ultrasonic wave is applied to the glass of the ultrasonic vibration container;ρrepresents the average density of the solution;ηindicating the average viscosity of the solution.
Further, the policy acquisition execution module includes:
the parameter extraction module is used for extracting container quality evaluation parameters corresponding to the current ultrasonic vibration container;
the frequency information acquisition module is used for acquiring the ultrasonic vibration frequency upper limit value of the bioactive substance of the target solution corresponding to the current bioactive substance by utilizing the container quality evaluation parameter and the vibration frequency range of the target solution corresponding to the current bioactive substance; wherein, the ultrasonic vibration frequency upper limit value is obtained by the following formula:
wherein,f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;Erepresenting a container quality assessment parameter;E 0 representing a preset parameter threshold;αrepresents a frequency adjustment parameter, and the expression of the frequency adjustment parameter is as follows:
wherein,v m representing the optimal sound velocity for bioactive substance extraction of the target solution;λ m indicating the optimal wavelength for bioactive substance extraction of the target solution;
the strategy parameter acquisition module is used for setting the maximum continuous vibration duration and the intermittent duration of the current ultrasonic vibration through the upper limit value of the ultrasonic vibration frequency of the bioactive substance, wherein the maximum continuous vibration duration limit value and the intermittent duration are acquired through the following formula:
wherein,T max representing a maximum duration limit;T cmax representing an initial maximum duration limit for the ultrasonically-vibrated container;f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;T z representing the intermittent duration;T cz indicating an initial intermittent duration of the ultrasonically-vibrated container;f m indicating an optimal vibration frequency for bioactive substance extraction of the target solution;
and the vibration control module is used for controlling the ultrasonic waves to carry out intermittent ultrasonic treatment on the target solution in the ultrasonic vibration container according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
The invention has the beneficial effects that: the ultrasonic vibration parameters are determined according to the surface area and the filling information of the container, so that the action range and the intensity of ultrasonic waves can be controlled more accurately, and the extraction efficiency of bioactive substances is improved; by utilizing the information in the database and combining the quality evaluation parameter of the container and the vibration frequency range of the target solution, the ultrasonic vibration frequency upper limit value and the vibration strategy which are most suitable for extracting the current bioactive substances can be determined, so that the technological parameters of the whole extraction process are optimized; the condition in the extraction process can be known in time by monitoring the containing condition of the container and the containing volume of the target solution in real time, and the condition is regulated and controlled according to the actual condition, so that the stability and consistency of the extraction process are ensured; by setting the limit value of the longest continuous vibration duration and the limit value of the intermittent duration of ultrasonic vibration, the use time and the energy consumption of ultrasonic waves can be reasonably controlled, so that the energy consumption cost is reduced. Meanwhile, the invention can reduce the loss of ultrasonic waves to the ultrasonic container, prolong the service life of the ultrasonic container and improve the stability and reliability of equipment.
Drawings
FIG. 1 is a flow chart of the method of the present invention;
fig. 2 is a system block diagram of the system of the present invention.
Detailed Description
The preferred embodiments of the present invention will be described below with reference to the accompanying drawings, it being understood that the preferred embodiments described herein are for illustration and explanation of the present invention only, and are not intended to limit the present invention.
The embodiment of the invention provides a bioactive substance extraction control method, as shown in fig. 1, which comprises the following steps:
s1, extracting the whole surface area and filling information of an ultrasonic vibration container corresponding to a target solution of a current bioactive substance;
s2, determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area and the filling information of the ultrasonic vibration container;
and S3, controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy, and obtaining the mixed solution with the bioactive substances.
The method for extracting the whole surface area and filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance comprises the following steps:
s101, monitoring whether the ultrasonic vibration container is filled with the target solution in real time;
s102, after the ultrasonic vibration container finishes filling of the target solution, acquiring the filling volume of the current target solution;
s103, extracting the whole surface area of the glass of the current ultrasonic vibration container from the database.
The working principle of the technical scheme is as follows: and extracting the whole surface area and filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance. The method specifically comprises the following steps: and monitoring whether the ultrasonic vibration container is filled with the target solution or not in real time. Monitoring whether the container is filled with the target solution in real time by a sensor or other monitoring means; and after the ultrasonic vibration container finishes filling of the target solution, acquiring the current filling volume of the target solution. After the container is filled, the volume of the target solution is measured to obtain accurate filling information and extract the whole surface area of the glass of the current ultrasonic vibration container from the database. And acquiring the glass surface area data of the current ultrasonic vibration container by querying a database. And determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substances according to the whole surface area and the filling information of the ultrasonic vibration container. Determining an upper limit value of ultrasonic vibration frequency and a vibration strategy suitable for extracting bioactive substances according to the surface area and the filling information of the container and by combining previous experience or model; and controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the determined ultrasonic vibration frequency range and the vibration strategy, and obtaining the mixed solution with the bioactive substances. According to the determined frequency range and strategy, the ultrasonic vibration container is vibrated according to set parameters, so that the bioactive substances in the target solution are effectively released and mixed with the solution.
The technical scheme has the effects that: the container is ensured to contain enough target solution for extraction by monitoring the filling condition of the ultrasonic vibration container and acquiring the filling volume of the target solution in real time, so that the extraction efficiency is improved; according to the whole surface area of the ultrasonic vibration container and the filling information, the ultrasonic vibration frequency upper limit value and the vibration strategy of the bioactive substances are determined, and the ultrasonic vibration parameters can be accurately controlled, so that the ultrasonic vibration parameters are suitable for different bioactive substance extraction requirements, and the extraction effect is more accurate and stable; according to the surface area and the filling information of the ultrasonic vibration container, the ultrasonic vibration frequency range and the vibration strategy suitable for extracting the bioactive substances are determined by combining previous experience or model, so that the extraction process can be optimized, and the extraction selectivity and yield can be improved; by reasonably controlling the ultrasonic vibration frequency range and the vibration strategy, the bioactive substances in the target solution can be effectively released and fully mixed with the solution, and the extracted mixed solution contains more bioactive substances, so that the extraction quality is improved; the whole extraction process can realize automatic control, reduces the working intensity of operators and improves the working efficiency through real-time monitoring and data processing.
According to one embodiment of the invention, the method for determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substance according to the whole surface area and the filling information of the ultrasonic vibration container comprises the following steps:
s201, acquiring a container quality evaluation parameter by utilizing the whole surface area of the glass of the current ultrasonic vibration container;
s202, extracting a vibration frequency range of a target solution corresponding to the current bioactive substances from a database;
s203, determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substances of the target solution corresponding to the current bioactive substances according to the container quality evaluation parameters.
Wherein, the container quality evaluation parameter is obtained by the following formula:
wherein,Erepresenting a container quality assessment parameter;nrepresenting the total number of extractions of the biologically active substance using ultrasound;F i represent the firstiThe maximum pressure of the ultrasonic wave acting on the glass of the ultrasonic vibration container;S i represent the firstiThe ultrasonic wave of the secondary ultrasonic wave acts on the average stress surface of the glass of the ultrasonic vibration container;Vrepresent the firstiThe volume of solution in the ultrasonic vibration container in the extraction of the secondary bioactive substances;Vrepresenting the container volume of the ultrasonically vibrated container;Pthe sound pressure of the ultrasonic wave;ωthe vibration angular frequency of the ultrasonic wave is represented; tan (tan)δRepresents the dielectric loss tangent;Srepresenting the overall surface area of the ultrasonically vibrated container;S p representing an average stress surface of the glass after the ultrasonic wave corresponding to the total extraction times of the bioactive substances applying the ultrasonic wave is applied to the glass of the ultrasonic vibration container;ρrepresents the average density of the solution;ηindicating the average viscosity of the solution.
The working principle of the technical scheme is as follows: the overall surface area of the glass of the current ultrasonically vibrated container is used to obtain the container quality assessment parameters. By measuring the glass surface area of the container, a quality assessment parameter of the container can be obtained. These parameters may reflect the mass and strength of the container, thereby determining the maximum power density that it can withstand; and extracting the vibration frequency range of the target solution corresponding to the current bioactive substances from the database. The vibration frequency ranges corresponding to the different bioactive substances are stored in the database. Extracting a corresponding vibration frequency range from a database according to the information of the current bioactive substances; and determining the ultrasonic vibration frequency upper limit value and the vibration strategy of the target solution corresponding to the current bioactive substances according to the container quality evaluation parameters. An upper limit value of the ultrasonic vibration frequency is determined based on the quality evaluation parameter of the container and the vibration frequency range of the target solution. Meanwhile, according to the characteristics of bioactive substances and extraction requirements, a vibration strategy is optimized to improve extraction efficiency and quality.
The technical scheme has the effects that: the ultrasonic vibration can destroy the structures of biological cell walls, cell membranes, cell nuclei and the like, and promote the release and extraction of bioactive substances. By determining the appropriate ultrasonic vibration frequency and strategy, the maximum range can be achievedThe extraction efficiency of bioactive substances is improved to a high degree; too high or too low a frequency of ultrasonic vibrations may have an influence on the structure and function of the biologically active substance and thus on its quality. By determining the proper upper limit value of the ultrasonic vibration frequency and optimizing the vibration strategy according to the container quality evaluation parameters, the reduction of the quality of the bioactive substances can be avoided to the greatest extent; the quality assessment parameters of the container may reflect the quality and strength of the container to determine the maximum power density that it can withstand. By determining the upper limit value of the ultrasonic vibration frequency and optimizing the vibration strategy according to the container quality evaluation parameters, the safety and reliability of the ultrasonic vibration container can be ensured, and the problems of container breakage or damage and the like are avoided. The scheme of the formula can quantitatively evaluate the quality of the container, optimize the extraction times of bioactive substances, and reduce the glass loss of the ultrasonic container under the condition of ensuring the optimal extraction amount of the bioactive substances to the maximum extent. Meanwhile, the quality of the container can be quantitatively evaluated through various parameters in the formula. This helps to determine the strength and reliability of the container to ensure that safety issues such as container breakage or rupture do not occur during ultrasonic vibration; the parameter n in the formula represents the total number of extractions of the biologically active substance to which the ultrasound is applied. Through reasonable setting of n, the extraction times of bioactive substances can be optimized, and the maximum extraction effect can be obtained under the minimum extraction times; parameters in the formulaS i 、F i 、S p And the like are related to the pressure and force bearing surfaces of the ultrasonic waves acting on the container glass. Consideration of these parameters may help determine the proper frequency and power of the ultrasonic waves to avoid excessive pressure and damage to the container glass.
According to one embodiment of the invention, the method for determining the ultrasonic vibration frequency upper limit value and the vibration strategy of the bioactive substance of the target solution corresponding to the current bioactive substance according to the container quality evaluation parameter comprises the following steps:
s2031, extracting container quality evaluation parameters corresponding to the current ultrasonic vibration container;
s2032, acquiring an ultrasonic vibration frequency upper limit value of the bioactive substance of the target solution corresponding to the current bioactive substance by using the container quality evaluation parameter and the vibration frequency range of the target solution corresponding to the current bioactive substance; wherein, the ultrasonic vibration frequency upper limit value is obtained by the following formula:
wherein,f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;Erepresenting a container quality assessment parameter;E 0 representing a preset parameter threshold;αrepresents a frequency adjustment parameter, and the expression of the frequency adjustment parameter is as follows:
wherein,v m representing the optimal sound velocity for bioactive substance extraction of the target solution;λ m indicating the optimal wavelength for bioactive substance extraction of the target solution;
s2033, setting a maximum duration limit value and an intermittent duration limit value of the current ultrasonic vibration through an upper limit value of the ultrasonic vibration frequency of the bioactive substance, wherein the maximum duration limit value and the intermittent duration limit value are obtained through the following formula:
wherein,T max representing a maximum duration limit;T cmax representing an initial maximum duration limit for the ultrasonically-vibrated container;f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;T z indicating intermittent timeLong;T cz indicating an initial intermittent duration of the ultrasonically-vibrated container;f m indicating an optimal vibration frequency for bioactive substance extraction of the target solution;
and S2034, controlling the ultrasonic waves to carry out intermittent ultrasonic treatment on the target solution in the ultrasonic vibration container according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
The working principle of the technical scheme is as follows: based on a given container, parameters associated with the container, such as container volume, material, surface area, etc., are obtained. These parameters will be used for subsequent evaluation and calculation; according to the container quality evaluation parameters and the requirements of the target solution, the upper limit value of the ultrasonic vibration frequency suitable for extracting the current bioactive substances is calculated by combining the influence of ultrasonic waves on the bioactive substances; determining the longest continuous vibration duration and intermittent duration of ultrasonic treatment according to the upper limit value of the ultrasonic vibration frequency so as to avoid unnecessary damage of ultrasonic waves to a container or a solution; and controlling the output of ultrasonic waves according to preset ultrasonic vibration parameters and treatment strategies, so that the ultrasonic waves are subjected to intermittent ultrasonic treatment on the target solution according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
The technical scheme has the effects that: the ultrasonic vibration frequency upper limit value and the vibration strategy suitable for extracting the current bioactive substances are determined, so that the effect of ultrasonic waves can be utilized to the greatest extent, and the extraction efficiency of the bioactive substances is improved; by determining the limitation of the longest continuous vibration duration and the intermittent duration of ultrasonic treatment according to the container quality evaluation parameters and the requirements of the target solution, unnecessary damage of ultrasonic waves to the container or the solution can be avoided; according to the technical scheme, the ultrasonic output can be automatically controlled, the workload of operators is reduced, and the working efficiency and the stability are improved; by improving the extraction efficiency of bioactive substances, the production cost can be reduced, and the competitiveness of the product can be improved. Each formula in the technical scheme considers the characteristics of container quality evaluation parameters, vibration frequency range and target solution, and achieves the effects of improving extraction efficiency, protecting containers and solutions and improving working efficiency and stability by reasonably adjusting parameters and controlling ultrasonic output. Meanwhile, the formula in step S2032 is for acquiring the ultrasonic vibration frequency upper limit value of the target solution of the bioactive substance. This formula takes into account the vessel quality evaluation parameters and the vibration frequency range of the target solution, as well as the optimal sound speed and wavelength. By adjusting the frequency adjustment parameter, an appropriate upper limit value of the ultrasonic vibration frequency can be determined according to the characteristics of the solution and the mass of the container. It may be possible to ensure that the maximum withstand frequency is not exceeded during application of the ultrasonic waves in the target solution, thereby avoiding damage to the target solution or container. The formula in step S2033 is used to set the longest continuous vibration duration and the intermittent duration limit in the ultrasonic vibration process. These limits are determined by considering the ultrasonic vibration frequency upper limit value, the vibration frequency range of the target solution, and the optimal vibration frequency. The maximum duration vibration limit and the intermittent duration are set to prevent the potential risk of excessive vibration of the container or solution by the ultrasonic waves. By using these limitations, it can be ensured that the ultrasonic vibration process is performed in a suitable time, avoiding potential damage and quality problems.
The embodiment of the invention provides a bioactive substance extraction control system, as shown in fig. 2, which comprises:
the information extraction module is used for extracting the whole surface area and the filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance;
the strategy setting module is used for determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area and the filling information of the ultrasonic vibration container;
and the system control module is used for controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy and obtaining the mixed solution with the bioactive substances.
Wherein, the information extraction module includes:
the real-time monitoring module is used for monitoring whether the ultrasonic vibration container is filled with the target solution in real time;
the volume information acquisition module is used for acquiring the current filling volume of the target solution after the ultrasonic vibration container finishes filling of the target solution;
and the glass parameter acquisition module is used for extracting the whole surface area of the glass of the current ultrasonic vibration container from the database.
The working principle of the technical scheme is as follows: and extracting the whole surface area and filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance. The method specifically comprises the following steps: and monitoring whether the ultrasonic vibration container is filled with the target solution or not in real time. Monitoring whether the container is filled with the target solution in real time by a sensor or other monitoring means; and after the ultrasonic vibration container finishes filling of the target solution, acquiring the current filling volume of the target solution. After the container is filled, the volume of the target solution is measured to obtain accurate filling information and extract the whole surface area of the glass of the current ultrasonic vibration container from the database. And acquiring the glass surface area data of the current ultrasonic vibration container by querying a database. And determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substances according to the whole surface area and the filling information of the ultrasonic vibration container. Determining an upper limit value of ultrasonic vibration frequency and a vibration strategy suitable for extracting bioactive substances according to the surface area and the filling information of the container and by combining previous experience or model; and controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the determined ultrasonic vibration frequency range and the vibration strategy, and obtaining the mixed solution with the bioactive substances. According to the determined frequency range and strategy, the ultrasonic vibration container is vibrated according to set parameters, so that the bioactive substances in the target solution are effectively released and mixed with the solution.
The technical scheme has the effects that: the container is ensured to contain enough target solution for extraction by monitoring the filling condition of the ultrasonic vibration container and acquiring the filling volume of the target solution in real time, so that the extraction efficiency is improved; according to the whole surface area of the ultrasonic vibration container and the filling information, the ultrasonic vibration frequency upper limit value and the vibration strategy of the bioactive substances are determined, and the ultrasonic vibration parameters can be accurately controlled, so that the ultrasonic vibration parameters are suitable for different bioactive substance extraction requirements, and the extraction effect is more accurate and stable; according to the surface area and the filling information of the ultrasonic vibration container, the ultrasonic vibration frequency range and the vibration strategy suitable for extracting the bioactive substances are determined by combining previous experience or model, so that the extraction process can be optimized, and the extraction selectivity and yield can be improved; by reasonably controlling the ultrasonic vibration frequency range and the vibration strategy, the bioactive substances in the target solution can be effectively released and fully mixed with the solution, and the extracted mixed solution contains more bioactive substances, so that the extraction quality is improved; the whole extraction process can realize automatic control, reduces the working intensity of operators and improves the working efficiency through real-time monitoring and data processing.
In one embodiment of the present invention, the policy setting module includes:
the evaluation parameter acquisition module is used for acquiring container quality evaluation parameters by utilizing the whole surface area of the glass of the current ultrasonic vibration container;
the frequency information acquisition module is used for extracting the vibration frequency range of the target solution corresponding to the current bioactive substances from the database;
and the strategy acquisition execution module is used for determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substance of the target solution corresponding to the current bioactive substance according to the container quality evaluation parameter.
Wherein, the container quality evaluation parameter is obtained by the following formula:
wherein,Erepresenting a container quality assessment parameter;nrepresenting the total number of extractions of the biologically active substance using ultrasound;F i represent the firstiThe maximum pressure of the ultrasonic wave acting on the glass of the ultrasonic vibration container;S i represent the firstiThe ultrasonic wave of the secondary ultrasonic wave acts on the average stress surface of the glass of the ultrasonic vibration container;Vrepresent the firstiSecondary bioactive substancesThe volume of solution in the ultrasonic vibration container in the extraction of the mass;Vrepresenting the container volume of the ultrasonically vibrated container;Pthe sound pressure of the ultrasonic wave;ωthe vibration angular frequency of the ultrasonic wave is represented; tan (tan)δRepresents the dielectric loss tangent;Srepresenting the overall surface area of the ultrasonically vibrated container;S p representing an average stress surface of the glass after the ultrasonic wave corresponding to the total extraction times of the bioactive substances applying the ultrasonic wave is applied to the glass of the ultrasonic vibration container;ρrepresents the average density of the solution;ηindicating the average viscosity of the solution.
The working principle of the technical scheme is as follows: the overall surface area of the glass of the current ultrasonically vibrated container is used to obtain the container quality assessment parameters. By measuring the glass surface area of the container, a quality assessment parameter of the container can be obtained. These parameters may reflect the mass and strength of the container, thereby determining the maximum power density that it can withstand; and extracting the vibration frequency range of the target solution corresponding to the current bioactive substances from the database. The vibration frequency ranges corresponding to the different bioactive substances are stored in the database. Extracting a corresponding vibration frequency range from a database according to the information of the current bioactive substances; and determining the ultrasonic vibration frequency upper limit value and the vibration strategy of the target solution corresponding to the current bioactive substances according to the container quality evaluation parameters. An upper limit value of the ultrasonic vibration frequency is determined based on the quality evaluation parameter of the container and the vibration frequency range of the target solution. Meanwhile, according to the characteristics of bioactive substances and extraction requirements, a vibration strategy is optimized to improve extraction efficiency and quality.
The technical scheme has the effects that: the ultrasonic vibration can destroy the structures of biological cell walls, cell membranes, cell nuclei and the like, and promote the release and extraction of bioactive substances. The extraction efficiency of bioactive substances can be improved to the greatest extent by determining the proper ultrasonic vibration frequency and strategy; too high or too low a frequency of ultrasonic vibrations may have an influence on the structure and function of the biologically active substance and thus on its quality. By determining the proper upper limit value of ultrasonic vibration frequency and optimizing the vibration strategy according to the container quality evaluation parameters, the method can maximally limitAvoiding a decrease in the quality of the bioactive substance; the quality assessment parameters of the container may reflect the quality and strength of the container to determine the maximum power density that it can withstand. By determining the upper limit value of the ultrasonic vibration frequency and optimizing the vibration strategy according to the container quality evaluation parameters, the safety and reliability of the ultrasonic vibration container can be ensured, and the problems of container breakage or damage and the like are avoided. The scheme of the formula can quantitatively evaluate the quality of the container, optimize the extraction times of bioactive substances, and reduce the glass loss of the ultrasonic container under the condition of ensuring the optimal extraction amount of the bioactive substances to the maximum extent. Meanwhile, the quality of the container can be quantitatively evaluated through various parameters in the formula. This helps to determine the strength and reliability of the container to ensure that safety issues such as container breakage or rupture do not occur during ultrasonic vibration; the parameter n in the formula represents the total number of extractions of the biologically active substance to which the ultrasound is applied. Through reasonable setting of n, the extraction times of bioactive substances can be optimized, and the maximum extraction effect can be obtained under the minimum extraction times; parameters in the formulaS i 、F i 、S p And the like are related to the pressure and force bearing surfaces of the ultrasonic waves acting on the container glass. Consideration of these parameters may help determine the proper frequency and power of the ultrasonic waves to avoid excessive pressure and damage to the container glass.
In one embodiment of the present invention, the policy acquisition execution module includes:
the parameter extraction module is used for extracting container quality evaluation parameters corresponding to the current ultrasonic vibration container;
the frequency information acquisition module is used for acquiring the ultrasonic vibration frequency upper limit value of the bioactive substance of the target solution corresponding to the current bioactive substance by utilizing the container quality evaluation parameter and the vibration frequency range of the target solution corresponding to the current bioactive substance; wherein, the ultrasonic vibration frequency upper limit value is obtained by the following formula:
wherein,f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;Erepresenting a container quality assessment parameter;E 0 representing a preset parameter threshold;αrepresents a frequency adjustment parameter, and the expression of the frequency adjustment parameter is as follows:
wherein,v m representing the optimal sound velocity for bioactive substance extraction of the target solution;λ m indicating the optimal wavelength for bioactive substance extraction of the target solution;
the strategy parameter acquisition module is used for setting the maximum continuous vibration duration and the intermittent duration of the current ultrasonic vibration through the upper limit value of the ultrasonic vibration frequency of the bioactive substance, wherein the maximum continuous vibration duration limit value and the intermittent duration are acquired through the following formula:
wherein,T max representing a maximum duration limit;T cmax representing an initial maximum duration limit for the ultrasonically-vibrated container;f up representing an upper limit value of the ultrasonic vibration frequency;f max representing a maximum value of the vibration frequency corresponding to the vibration frequency range of the target solution;T z representing the intermittent duration;T cz indicating an initial intermittent duration of the ultrasonically-vibrated container;f m indicating an optimal vibration frequency for bioactive substance extraction of the target solution;
and the vibration control module is used for controlling the ultrasonic waves to carry out intermittent ultrasonic treatment on the target solution in the ultrasonic vibration container according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
The working principle of the technical scheme is as follows: based on a given container, parameters associated with the container, such as container volume, material, surface area, etc., are obtained. These parameters will be used for subsequent evaluation and calculation; according to the container quality evaluation parameters and the requirements of the target solution, the upper limit value of the ultrasonic vibration frequency suitable for extracting the current bioactive substances is calculated by combining the influence of ultrasonic waves on the bioactive substances; determining the longest continuous vibration duration and intermittent duration of ultrasonic treatment according to the upper limit value of the ultrasonic vibration frequency so as to avoid unnecessary damage of ultrasonic waves to a container or a solution; and controlling the output of ultrasonic waves according to preset ultrasonic vibration parameters and treatment strategies, so that the ultrasonic waves are subjected to intermittent ultrasonic treatment on the target solution according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
The technical scheme has the effects that: the ultrasonic vibration frequency upper limit value and the vibration strategy suitable for extracting the current bioactive substances are determined, so that the effect of ultrasonic waves can be utilized to the greatest extent, and the extraction efficiency of the bioactive substances is improved; by determining the limitation of the longest continuous vibration duration and the intermittent duration of ultrasonic treatment according to the container quality evaluation parameters and the requirements of the target solution, unnecessary damage of ultrasonic waves to the container or the solution can be avoided; according to the technical scheme, the ultrasonic output can be automatically controlled, the workload of operators is reduced, and the working efficiency and the stability are improved; by improving the extraction efficiency of bioactive substances, the production cost can be reduced, and the competitiveness of the product can be improved. Each formula in the technical scheme considers the characteristics of container quality evaluation parameters, vibration frequency range and target solution, and achieves the effects of improving extraction efficiency, protecting containers and solutions and improving working efficiency and stability by reasonably adjusting parameters and controlling ultrasonic output. Meanwhile, the formula in the frequency information acquisition module is used for acquiring the upper limit value of the ultrasonic vibration frequency of the target solution of the bioactive substance. This formula takes into account the vessel quality evaluation parameters and the vibration frequency range of the target solution, as well as the optimal sound speed and wavelength. By adjusting the frequency adjustment parameter, an appropriate upper limit value of the ultrasonic vibration frequency can be determined according to the characteristics of the solution and the mass of the container. It may be possible to ensure that the maximum withstand frequency is not exceeded during application of the ultrasonic waves in the target solution, thereby avoiding damage to the target solution or container. The formula in the strategy parameter acquisition module is used for setting the longest continuous vibration duration and the intermittent duration limit in the ultrasonic vibration process. These limits are determined by considering the ultrasonic vibration frequency upper limit value, the vibration frequency range of the target solution, and the optimal vibration frequency. The maximum duration vibration limit and the intermittent duration are set to prevent the potential risk of excessive vibration of the container or solution by the ultrasonic waves. By using these limitations, it can be ensured that the ultrasonic vibration process is performed in a suitable time, avoiding potential damage and quality problems.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (8)
1. A bioactive substance extraction control method, characterized by comprising:
extracting the whole surface area and filling information of an ultrasonic vibration container corresponding to the target solution of the current bioactive substance;
determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area of the ultrasonic vibration container and the filling information;
and controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy, and obtaining the mixed solution with the bioactive substances.
2. The method according to claim 1, wherein the extracting of the entire surface area and the loading information of the ultrasonic vibration container corresponding to the target solution of the present bioactive substance includes:
monitoring whether the ultrasonic vibration container is filled with the target solution in real time;
when the ultrasonic vibration container finishes filling of the target solution, acquiring the current filling volume of the target solution;
the entire surface area of the glass of the current ultrasonically-vibrated container is extracted from the database.
3. The method of claim 1, wherein determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substance based on the entire surface area of the ultrasonic vibration container and the loading information, comprises:
acquiring a container quality evaluation parameter by utilizing the whole surface area of the glass of the current ultrasonic vibration container;
extracting a vibration frequency range of a target solution corresponding to the current bioactive substances from a database;
and determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substances of the target solution corresponding to the current bioactive substances according to the container quality evaluation parameters.
4. The method according to claim 3, wherein determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substance of the target solution corresponding to the current bioactive substance based on the container quality evaluation parameter comprises:
extracting container quality evaluation parameters corresponding to the current ultrasonic vibration container;
acquiring an ultrasonic vibration frequency upper limit value of the bioactive substance of the target solution corresponding to the current bioactive substance by utilizing the container quality evaluation parameter and the vibration frequency range of the target solution corresponding to the current bioactive substance;
setting the maximum duration and the intermittent duration limit of the current ultrasonic vibration through the upper limit value of the ultrasonic vibration frequency of the bioactive substance;
and controlling the ultrasonic waves to carry out intermittent ultrasonic treatment on the target solution in the ultrasonic vibration container according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
5. A bioactive substance extraction control system, characterized in that the bioactive substance extraction control system comprises:
the information extraction module is used for extracting the whole surface area and the filling information of the ultrasonic vibration container corresponding to the target solution of the current bioactive substance;
the strategy setting module is used for determining an ultrasonic vibration frequency upper limit value and a vibration strategy of the bioactive substances according to the whole surface area and the filling information of the ultrasonic vibration container;
and the system control module is used for controlling the ultrasonic vibration container to carry out ultrasonic vibration on the target solution according to the ultrasonic vibration frequency range and the vibration strategy and obtaining the mixed solution with the bioactive substances.
6. The bioactive substance extraction control system of claim 5, wherein said information extraction module comprises:
the real-time monitoring module is used for monitoring whether the ultrasonic vibration container is filled with the target solution in real time;
the volume information acquisition module is used for acquiring the current filling volume of the target solution after the ultrasonic vibration container finishes filling of the target solution;
and the glass parameter acquisition module is used for extracting the whole surface area of the glass of the current ultrasonic vibration container from the database.
7. The bioactive substance extraction control system of claim 5, wherein said policy setting module comprises:
the evaluation parameter acquisition module is used for acquiring container quality evaluation parameters by utilizing the whole surface area of the glass of the current ultrasonic vibration container;
the frequency information acquisition module is used for extracting the vibration frequency range of the target solution corresponding to the current bioactive substances from the database;
and the strategy acquisition execution module is used for determining the upper limit value of the ultrasonic vibration frequency and the vibration strategy of the bioactive substance of the target solution corresponding to the current bioactive substance according to the container quality evaluation parameter.
8. The bioactive substance extraction control system of claim 7, wherein the policy acquisition enforcement module comprises:
the parameter extraction module is used for extracting container quality evaluation parameters corresponding to the current ultrasonic vibration container;
the frequency information acquisition module is used for acquiring the ultrasonic vibration frequency upper limit value of the bioactive substance of the target solution corresponding to the current bioactive substance by utilizing the container quality evaluation parameter and the vibration frequency range of the target solution corresponding to the current bioactive substance;
the strategy parameter acquisition module is used for setting the maximum duration vibration time and the intermittent duration time limit value of the current ultrasonic vibration through the upper limit value of the ultrasonic vibration frequency of the bioactive substance;
and the vibration control module is used for controlling the ultrasonic waves to carry out intermittent ultrasonic treatment on the target solution in the ultrasonic vibration container according to the upper limit value of the ultrasonic vibration frequency, the longest continuous vibration duration and the intermittent duration.
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