CN117482175A - Traditional Chinese medicine composition for treating diabetic nephropathy - Google Patents
Traditional Chinese medicine composition for treating diabetic nephropathy Download PDFInfo
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- CN117482175A CN117482175A CN202311796166.4A CN202311796166A CN117482175A CN 117482175 A CN117482175 A CN 117482175A CN 202311796166 A CN202311796166 A CN 202311796166A CN 117482175 A CN117482175 A CN 117482175A
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Abstract
The application relates to a traditional Chinese medicine composition for treating diabetic nephropathy, which comprises the following raw material medicines: radix Pseudostellariae, polygoni Multiflori radix, bombyx Batryticatus preparata, ramulus Euonymi, fructus Lycii, semen Cassiae, trichosanthis radix, rhizoma anemarrhenae, rhizoma Polygonati, herba Lycopi, saviae Miltiorrhizae radix, carthami flos, radix Paeoniae Rubra, corni fructus, fructus Rosae Laevigatae, and rhizoma Cibotii. The Chinese medicinal composition has the main treatment principles of tonifying liver and kidney, promoting blood circulation to remove blood stasis and resolving hard mass, clearing and purging yin and nourishing yin, and has the effects of both attacking and tonifying, nourishing yin without greasy, strengthening body resistance and not helping evil. The whole formula integrates the functions of tonifying qi, nourishing liver, nourishing kidney, promoting blood circulation, nourishing yin and clearing diarrhea, and is particularly suitable for diabetic nephropathy patients.
Description
Technical Field
The invention belongs to the technical field of preparation and application of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of medicines for preventing and treating diabetic nephropathy.
Background
Diabetes mellitus is a clinically common endocrine and metabolic abnormality disease and is mainly characterized in that the continuous abnormal rise of blood sugar level can lead to various complications of patients, and the complications mainly comprise eye injury, microvascular injury and the like. Diabetic Nephropathy (DN) is one of the most common microvascular complications, leading to both a higher risk and mortality of chronic renal failure. In the current clinic, aiming at DN, drugs are mainly used for treating, usually blood sugar and blood pressure reducing lipid reducing and anticoagulation drugs are used for controlling the blood sugar level of patients, biguanides such as metformin, sulfonylurea glimepiride, alpha glycoside inhibitor acarbose and the like are used for relieving symptoms, but the effect is not ideal.
In traditional Chinese medicine, diabetic nephropathy belongs to the scope of diabetes, and is considered that DN is related to yin qi loss, five viscera injury, concurrent depression, heat, blood stasis, phlegm and the like caused by long-time diabetes and kidney deficiency of patients, and the diseases are caused by deficiency of liver-yin and kidney-yin during early onset, and the deficiency of yang qi and kidney spleen, and the decline of kidney yang, internal accumulation and turbidity toxin, and weak manifestations of five viscera, so that effective treatment needs to be carried out as early as possible to improve the illness state. It can be seen that the traditional Chinese medicine treatment of the disease should follow the principles of tonifying qi and nourishing yin, activating blood and resolving stasis, tonifying kidney and securing essence, warming yang and transforming qi, etc.
The glycolipid cleaning granule is a hospital preparation in Jiangsu province, mainly comprises radix pseudostellariae, polygonum multiflorum, roasted stiff silkworm, winged euonymus twig, medlar, semen cassiae, radix trichosanthis and other medicines, and is mainly used for treating diabetes mellitus, and related diseases such as reducing blood sugar, glycosylated hemoglobin, reducing insulin, increasing insulin sensitivity and regulating blood fat. Patent CN 2010101832736 discloses a basic prescription and the dosage thereof, 8-20 parts of rhizoma polygonati, 5-15 parts of roasted stiff silkworm, 5-15 parts of winged euonymus twig, 8-20 parts of medlar and 10-20 parts of herba lycopi. The preparation takes tonifying liver and kidney, resolving phlegm and removing blood stasis as a treatment rule, integrates the functions of nourishing liver, tonifying kidney, promoting blood circulation, resolving phlegm, removing fat and dredging collaterals into one furnace, and is especially suitable for people with diabetes complicated with hyperlipidemia belonging to liver-kidney yin deficiency and phlegm and blood stasis and obstruction of collaterals. In the prior art, similar formulas are disclosed more, but specific dosage and specific compatibility principles are not disclosed, and specific researches on diabetic nephropathy are not developed. The invention is based on rhizoma polygonati, roasted stiff silkworm, winged euonymus twig, medlar and herba lycopi as main drugs, and the use amount of each main drug is definitely and adjusted according to the cause of disease, and the salvia miltiorrhiza which can activate blood and tonify kidney is added on the basis of the formula, so that the salvia miltiorrhiza removes blood stasis without hurting the vital energy, is a key drug for activating blood, and is proved by modern clinical researches, and tanshinone IIA and water-soluble salvianolic acid compounds can regulate blood sugar and are used for DN patients. Patients are always in a high-sugar and diuretic state and blood stasis is common, so that the red sage root and safflower, red paeony root and the like are matched with each other to achieve good effects of promoting blood circulation and removing blood stasis. The kidney deficiency causes yin qi loss, and fructus corni and cherokee rose fruit which are used for tonifying kidney, nourishing yin, astringing and inducing astringency are added, so that modern clinical researches show that the fructus cherokee rose fruit and fructus corni water extract can inhibit vascular ACE. Rhizoma Cibotii for nourishing liver and kidney is added, and fructus Lycii is added to enhance the effects of nourishing kidney yin, replenishing vital essence and nourishing blood, and fructus Lycii extract polysaccharide can enhance the kidney protecting function of diabetes. The rhizoma anemarrhenae and the radix trichosanthis are added for combination, so that the effects of clearing heat, nourishing yin and purging pathogenic fire are enhanced, and the effects of tonifying and strengthening body resistance are achieved without helping evil.
Disclosure of Invention
Provides a traditional Chinese medicine composition specially used for treating diabetic nephropathy and a preparation method thereof, and solves the problems of the existing medicines proposed in the background art.
The technical scheme adopted by the invention is as follows:
a Chinese medicinal composition for treating diabetic nephropathy is provided: 8-20 parts of radix pseudostellariae, 8-20 parts of polygonum multiflorum, 10-25 parts of roasted stiff silkworm, 10-25 parts of winged euonymus twig, 20-40 parts of medlar, 8-20 parts of semen cassiae, 10-20 parts of radix trichosanthis, 10-20 parts of rhizoma anemarrhenae, 10-30 parts of rhizoma polygonati, 10-30 parts of herba lycopi, 20-40 parts of radix salviae miltiorrhizae, 20-40 parts of safflower, 10-30 parts of red paeony root, 10-30 parts of dogwood, 10-30 parts of cherokee rose fruit and 10-30 parts of rhizoma cibotii.
The specific drug efficacy is as follows:
radix pseudostellariae: sweet and slightly bitter in nature and flat. Enter spleen and lung meridians. The main functions are as follows: replenishing qi to invigorate the spleen, promoting fluid production and moistening the lung. Can be used for treating spleen deficiency, tiredness, inappetence, asthenia after illness, deficiency of qi and yin, spontaneous perspiration, thirst, and dry cough due to lung dryness.
Polygonum multiflorum Thunb: bitter, sweet and astringent in flavor and warm in nature. It enters liver, heart and kidney meridians. The main functions are as follows: detoxify, remove carbuncle, moisten intestine and relieve constipation. Can be used for treating scrofula, sore, carbuncle, rubella, pruritus, constipation due to intestinal dryness; hyperlipidemia.
Stiff silkworm stir-baked: salty and pungent in nature and flat in nature. It enters liver, lung and stomach meridians. The main functions are as follows: dispelling wind, arresting convulsion, resolving phlegm and resolving masses. Can be used for treating convulsion, laryngopharynx swelling and pain, skin pruritus, submaxillary lymphadenitis, and facial paralysis.
Ramulus Euonymi: bitter and cold in nature. Enter the jueyin meridian. The main functions are as follows: broken blood, unblock the channels and kill parasites. For amenorrhea, abdominal mass, postpartum stagnant abdominal pain, and worm accumulation abdominal pain.
Wolfberry fruit: sweet in nature and flat in flavor. It enters liver and kidney meridians. The main functions are as follows: nourishing liver and kidney, replenishing essence and improving eyesight. Can be used for treating asthenia, essence deficiency, soreness of waist and knees, dizziness, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision.
Semen cassiae: sweet, bitter, salty and slightly cold in nature. Enter liver and large intestine meridians. The main functions are as follows: clear heat and improve eyesight, moisten intestines and relieve constipation. Can be used for treating conjunctival congestion, pain, photophobia, lacrimation, headache, dizziness, dim eyesight, constipation.
Radix trichosanthis: sweet and slightly bitter in flavor and slightly cold in nature. Enter lung and stomach meridians. The main functions are as follows: clearing heat and promoting salivation, detumescence and expelling pus. Can be used for treating pyretic polydipsia, lung heat dryness cough, internal heat diabetes, and pyocutaneous disease.
Rhizoma anemarrhenae: bitter, sweet and cold in nature. It enters lung, stomach and kidney meridians. The main functions are as follows: clearing heat and purging fire, promoting fluid production and moistening dryness. Can be used for treating exogenous febrile disease, hyperpyrexia, polydipsia, lung heat, dry cough, hectic fever, internal heat, diabetes, constipation, and intestinal dryness.
Rhizoma polygonati: sweet in nature and flat in flavor. Enter spleen, lung and kidney meridians. The main functions are as follows: tonifying qi and yin, strengthening spleen, moistening lung and tonifying kidney. Can be used for treating weakness of spleen and stomach, tiredness, debilitation, dry mouth, anorexia, lung deficiency, cough, essence and blood deficiency, internal heat and diabetes.
Herba Lycopi: bitter and pungent in flavor and slightly warm. Enter liver and spleen meridians. The main functions are as follows: promoting blood circulation to remove blood stasis, and inducing diuresis to alleviate edema. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, and edema.
Root of red-rooted salvia: bitter in flavor and slightly cold in nature. It enters heart and liver meridians. The main functions are as follows: remove blood stasis, relieve pain, activate blood, promote menstruation, clear heart and relieve restlessness. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracoabdominal pain, arthralgia due to heat, sore pain, vexation, and insomnia; hepatosplenomegaly and angina pectoris.
Safflower: pungent and warm in nature. It enters heart and liver meridians. The main functions are as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochia, mass, traumatic injury, and swelling and pain of pyocutaneous disease.
Radix paeoniae rubra: bitter in flavor and slightly cold in nature. Enter liver meridian. The main functions are as follows: clear heat and cool blood, dissipate blood stasis and relieve pain. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling and ulcer.
Fructus Corni: sour and astringent in nature and slightly warm. It enters liver and kidney meridians. The main functions are as follows: tonify liver and kidney, astringe essence and arrest spontaneous emission. Can be used for treating vertigo, tinnitus, soreness of waist and knees, impotence, spermatorrhea, enuresis, frequent urination, metrorrhagia, leukorrhagia, and excessive sweat. Internal heat and diabetes.
Cherokee rose fruit: sour, sweet, astringent and flat nature. Enter kidney, bladder and large intestine meridians. The main functions are as follows: to arrest seminal emission and reduce urination, astringe intestines and check diarrhea. It can be used for treating spermatorrhea, enuresis, frequent urination, metrorrhagia, leukorrhagia, and chronic diarrhea and dysentery.
Rhizoma Cibotii: bitter and sweet in flavor and warm in nature. It enters liver and kidney meridians. The main functions are as follows: liver and kidney tonifying, waist and spine strengthening, and wind-damp expelling. Can be used for treating soreness of waist and knees, weakness of lower limbs, and rheumatalgia.
The recipe has the main treatment principles of nourishing liver and kidney, promoting blood circulation to remove blood stasis and resolving hard mass, clearing and purging yin and nourishing yin, and has the functions of both attacking and tonifying, nourishing yin without greasy, strengthening body resistance and not assisting evil. Compared with the original prescription, the traditional Chinese medicine composition has the advantages of focusing on tonifying kidney and activating blood, particularly has good effect on patients suffering from kidney diseases, and has remarkable effect on reaching focus of disease aiming at specific patients on the basis of keeping the original prescription. The whole formula is integrated with the functions of tonifying qi, nourishing liver, nourishing kidney, promoting blood circulation, nourishing yin and clearing diarrhea, and is particularly suitable for diabetic nephropathy patients.
Detailed Description
Example 1
A Chinese medicinal composition for treating diabetic nephropathy is prepared from the following raw materials: 15-20 parts of radix pseudostellariae, 15-20 parts of polygonum multiflorum, 15-25 parts of roasted stiff silkworm, 15-25 parts of winged euonymus twig, 30-40 parts of medlar, 15-20 parts of semen cassiae, 15-20 parts of radix trichosanthis, 15-20 parts of rhizoma anemarrhenae, 20-30 parts of rhizoma polygonati, 20-30 parts of herba lycopi, 30-40 parts of radix salviae miltiorrhizae, 30-40 parts of safflower, 20-30 parts of radix paeoniae rubra, 20-30 parts of dogwood, 20-30 parts of cherokee rose and 20-30 parts of rhizoma cibotii, washing, sterilizing, drying, crushing, sieving and uniformly mixing; adding water to make into honey water, mixing with the medicinal powder, and making into honeyed pill.
Example 2
A Chinese medicinal composition for treating diabetic nephropathy is prepared from the following raw materials: 20 parts of radix pseudostellariae, 20 parts of polygonum multiflorum, 25 parts of roasted stiff silkworm, 25 parts of winged euonymus twig, 40 parts of medlar, 20 parts of semen cassiae, 20 parts of radix trichosanthis, 20 parts of rhizoma anemarrhenae, 30 parts of rhizoma polygonati, 30 parts of herba lycopi, 40 parts of radix salviae miltiorrhizae, 40 parts of safflower, 30 parts of red paeony root, 30 parts of dogwood, 30 parts of cherokee rose fruit and 30 parts of rhizoma cibotii, adding 3-5 times of water for decoction, continuously decocting for 3 times, filtering, concentrating under reduced pressure to obtain an extract, and adding auxiliary materials into the extract to prepare an oral preparation.
Example 3
Further, taking the raw materials: 20 parts of radix pseudostellariae, 20 parts of polygonum multiflorum, 25 parts of roasted stiff silkworm, 25 parts of winged euonymus twig, 40 parts of medlar, 20 parts of semen cassiae, 20 parts of radix trichosanthis, 20 parts of rhizoma anemarrhenae, 30 parts of rhizoma polygonati, 30 parts of herba lycopi, 40 parts of radix salviae miltiorrhizae, 40 parts of safflower, 30 parts of red paeony root, 30 parts of dogwood, 30 parts of cherokee rose fruit and 30 parts of rhizoma cibotii, washing, sterilizing by microwaves, drying, crushing, sieving by a 110-120 mesh sieve, and uniformly mixing; refining honey to 135-145 ℃ with water content of 11-12%, and then mixing with honey: adding water at a weight ratio of 1:3.5-1:4.5 to obtain honey water, and then mixing the honey water with medicinal powder: the weight ratio of the honey water to the pill is 1:1.25-1.45, the honey water is evenly mixed and enters a pill making machine to be made into water honey pills, and the weight of the water honey pills is 45 g.
The invention provides an application of a traditional Chinese medicine composition with a function of treating diabetic nephropathy in preparing medicines for preventing and treating diabetic nephropathy.
As a preferable scheme, the traditional Chinese medicine composition provided by the invention is applied to the preparation of medicines for preventing and treating diabetic nephropathy.
Case origin conditions: the cases were taken from Xuzhou middle school, 7 months 2020 to 7 months 2021, 100 total, 60 men and 40 women, ages 35-68, average ages 45+ -5.0, and disease course 5-13 years.
Control group: the glycolipid cleaning granule, CN 2010101832736 discloses a basic prescription and the dosage thereof, 12 parts of rhizoma polygonati, 10 parts of roasted stiff silkworm, 10 parts of winged euonymus twig, 12 parts of medlar and 15 parts of herba lycopi.
Experimental group: the medicine composition and the preparation method are as follows: 20 parts of radix pseudostellariae, 20 parts of polygonum multiflorum, 25 parts of roasted stiff silkworm, 25 parts of winged euonymus twig, 40 parts of medlar, 20 parts of semen cassiae, 20 parts of radix trichosanthis, 20 parts of rhizoma anemarrhenae, 30 parts of rhizoma polygonati, 30 parts of herba lycopi, 40 parts of radix salviae miltiorrhizae, 40 parts of safflower, 30 parts of red paeony root, 30 parts of dogwood, 30 parts of cherokee rose fruit and 30 parts of rhizoma cibotii, and the medicine is decocted with water for 1 dose/d for 1 time in the morning and evening.
Both groups of patients were observed after a duration of 9 weeks of treatment.
And (3) observing the indexes: the two groups of patients were compared for the renal function index urea nitrogen (BUN), serum Creatinine (SCR), blood urine microglobulin (β2-MG), glycemic index fasting glucose (FBG), postprandial 2h glucose (2 hPG) before and after 9 weeks of treatment. BUN, SCR, beta 2-MG, FBG and 2 hPa levels were detected by using a Hitachi 7600 full-automatic biochemical analyzer.
Treatment results: the effect is shown: the blood sugar is reduced to below 7.8mmol/L, urine sugar and urine protein (-) are quantified, BUN, CRE, SCR and beta 2-MG in blood are normal in 24 hours, and symptoms disappear; the method is effective: the blood sugar is reduced by more than 30 percent compared with the blood sugar before treatment, urine sugar is (+/-) - (+), urine protein is quantified for 24 hours, and BUN, CRE, SCR and beta 2-MG in blood are reduced by 50 percent compared with the blood sugar before treatment, so that the symptoms are obviously reduced; invalidation: the decrease of BUN, CRE, SCR and beta 2-MG in blood, urine sugar and urine protein is not obvious, and the symptoms are not obviously improved. The treatment conditions and the changes of various biochemical indexes observed before and after are shown in the following tables 1-3.
After treatment, the total effective rate of the experimental group is 96.00% and is higher than that of the control group by 80.00%, and the two groups have no significant difference (> 0.05) and are shown in table 1.
Table 1 comparison of clinical efficacy
| Group of | Number of examples | Has obvious effect | Effective and effective | Invalidation of | Effective rate of |
| Experimental group | 50 | 33 | 15 | 2 | 96.00 |
| Control group | 50 | 14 | 26 | 10 | 80.00 |
TABLE 2 Biochemical index Change before and after treatment
| Group of | Time | BUN | SCR | β2-MG | Urine protein g/24h |
| Experimental group | Before treatment | 10.02±4.95 | 143.85±18.36 | 3.72±1.08 | 3.70±1.58 |
| （n=50） | After treatment | 5.33±1.25 *# | 88.35±15.65 *# | 2.35±0.23 *# | 0.78±0.47 *# |
| Control group | Before treatment | 10.13±5.11 | 139.13±20.67 | 3.85±1.18 | 3.60±1.48 |
| （n=50） | After treatment | 6.7±1.15 * | 102.35±19.08 * | 1.90±0.24 * | 0.85±0.45 * |
In comparison with the pre-treatment period of this group, * P<0.05; compared with the treatment of the control group, # P <0.05。
TABLE 3 blood glucose level change before and after treatment
Taken together, the total effective rate of treatment for the two groups of patients was relatively insignificant (> 0.05). After 9 weeks of treatment, the 24h urine protein quantification and the blood BUN, CRE, SCR, beta 2-MG, FBG and 2 hPa levels of the two groups of patients are obviously reduced compared with those of the two groups of patients before treatment, and the reduction amplitude of the experimental group after treatment is obviously higher than that of the control group (< 0.05).
The traditional Chinese medicine composition with the function of treating diabetic nephropathy can be prepared into oral liquid, granules, capsules, tablets, powder injection or injection dosage forms by extracts of the raw materials and pharmaceutically acceptable carriers.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (7)
1. A traditional Chinese medicine composition for treating diabetic nephropathy comprises the following raw materials in parts by weight: 8-20 parts of radix pseudostellariae, 8-20 parts of polygonum multiflorum, 10-25 parts of roasted stiff silkworm, 10-25 parts of winged euonymus twig, 20-40 parts of medlar, 8-20 parts of semen cassiae, 10-20 parts of radix trichosanthis, 10-20 parts of rhizoma anemarrhenae, 10-30 parts of rhizoma polygonati, 10-30 parts of herba lycopi, 20-40 parts of radix salviae miltiorrhizae, 20-40 parts of safflower, 10-30 parts of red paeony root, 10-30 parts of dogwood, 10-30 parts of cherokee rose fruit and 10-30 parts of rhizoma cibotii.
2. A traditional Chinese medicine composition for treating diabetic nephropathy comprises the following raw materials in parts by weight: 15-20 parts of radix pseudostellariae, 15-20 parts of polygonum multiflorum, 15-25 parts of roasted stiff silkworm, 15-25 parts of winged euonymus twig, 30-40 parts of medlar, 15-20 parts of semen cassiae, 15-20 parts of radix trichosanthis, 15-20 parts of rhizoma anemarrhenae, 20-30 parts of rhizoma polygonati, 20-30 parts of herba lycopi, 30-40 parts of radix salviae miltiorrhizae, 30-40 parts of safflower, 20-30 parts of red paeony root, 20-30 parts of dogwood, 20-30 parts of cherokee rose fruit and 20-30 parts of rhizoma cibotii.
3. The traditional Chinese medicine composition according to claim 1 or 2, comprising the following raw materials in parts by weight: 20 parts of radix pseudostellariae, 20 parts of polygonum multiflorum, 25 parts of roasted stiff silkworm, 25 parts of winged euonymus twig, 40 parts of medlar, 20 parts of semen cassiae, 20 parts of radix trichosanthis, 20 parts of rhizoma anemarrhenae, 30 parts of rhizoma polygonati, 30 parts of herba lycopi, 40 parts of radix salviae miltiorrhizae, 40 parts of safflower, 30 parts of red paeony root, 30 parts of dogwood, 30 parts of cherokee rose fruit and 30 parts of rhizoma cibotii.
4. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-3, wherein the raw materials are taken, washed with water, sterilized, dried, crushed, sieved and uniformly mixed; adding water to make into honey water, mixing with the medicinal powder, and making into honeyed pill.
5. A method for preparing a traditional Chinese medicine composition according to claims 1-3, characterized by the specific steps of: weighing the traditional Chinese medicine raw materials with the prescription amount, adding 3-5 times of water for decoction, continuously decocting for 3 times, filtering, concentrating under reduced pressure to obtain extract, adding auxiliary materials into the extract, and preparing into oral dosage forms.
6. The method for preparing a Chinese medicinal composition according to claim 4, wherein the Chinese medicinal composition is prepared by washing with water, sterilizing with microwave, drying, pulverizing, sieving with 110-120 mesh sieve, and mixing; refining honey to 135-145 ℃ with water content of 11-12%, and then mixing with honey: adding water at a weight ratio of 1:3.5-1:4.5 to obtain honey water, and then mixing the honey water with medicinal powder: the weight ratio of the honey water to the pill is 1:1.25-1.45, the honey water is evenly mixed and enters a pill making machine to be made into water honey pills, and the weight of the water honey pills is 45 g.
7. Use of the Chinese medicinal composition according to any one of claims 1-6 in the preparation of a medicament for treating diabetic nephropathy.
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| CN202311796166.4A CN117482175A (en) | 2023-12-25 | 2023-12-25 | Traditional Chinese medicine composition for treating diabetic nephropathy |
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