CN117467762A - Probe composition and kit for breast cancer gene detection - Google Patents
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Abstract
The invention relates to the technical field of gene detection, in particular to a probe composition and a kit for breast cancer gene detection. The invention realizes the full coverage screening of the gene variation (SNVs, SVs) of the breast cancer related genes with low cost, high flux and short period by carefully designing the long fragment capturing and amplifying technology of the breast cancer genes and combining the three-generation long reading long sequencing technology. The invention improves the detection rate of structural variation of breast cancer genes and the clinical accessibility of large-scale screening: 1. the problem of false negative caused by incomplete detection of structural variation of breast cancer genes by a second-generation sequencing detection technology is solved; 2. solves the difficulties of high cost, small flux and inconvenient popularization of the detection of the breast cancer genes by using the three-generation whole genome sequencing, and has remarkable clinical popularization and application values.
Description
Technical Field
The invention relates to the technical field of gene detection, in particular to a probe composition and a kit for breast cancer gene detection.
Background
Breast cancer is the most common malignancy in women worldwide, with about 5-10% of all breast cancer patients having a family history that follows mendelian inheritance patterns, this part of breast cancer being known as hereditary breast cancer, thought to be caused by a single gene, and modern gene detection means found that about 50% of hereditary breast cancers are caused by BRCA1/2 mutations, other causative genes also including CHECK2, ATM, PALB2, and the like. For breast cancer patients with family history, the national integrated cancer network (The National Comprehensive Cancer Network, NCCN) will issue clinical guidelines for diagnosis and treatment of cancer on a regular basis, recommending BRCA1/2 gene testing or multi-gene chip testing covering about 20 genes.
Most of the genetic breast cancer pathogenic genes known at present are directly involved in DNA damage repair, and meanwhile, 40% of sporadic breast cancers have DNA homologous recombination repair pathway defects, so that genome instability is a key molecular characteristic of breast cancer, and structural variation directly shows genome instability. Structural Variations (SVs), including insertions, deletions, replications, inversions and placements, produce a greater change in structural variation than Single Nucleotide Variations (SNVs) affect the genome. Structural variation has been found in previous studies to be a common variation, and some specific variations are known to cause genetic diseases and cancers. Previous studies on the effect of structural variation on gene structure and expression have greatly deepened our understanding of tumorigenesis. Many oncogenes have been demonstrated to be products of chromosomal translocation and can be targeted for therapy.
Common structural variations include:
sanger sequencing: the known gene mutation locus is detected, and the target region gene is amplified and sequenced by designing a specific primer, so that the method has the advantages of high accuracy, incapability of detecting unknown mutation and low detection flux.
In situ fluorescence hybridization (FISH) technique: and designing a fluorescent probe of the breast cancer gene, hybridizing with the nucleus of the tissue cell to be detected, developing, and observing the hybridization developing condition of the probe in the cell. The number of the single detectable genes is limited by the type of fluorescent group luminescence, different genes are distinguished according to the luminescence color, and the detection can only be carried out by designing probes aiming at known variation. And the sample requirement is higher, the operation is complicated, and the result interpretation is not easy to observe and interpret.
Gene chip technology: a large number of pre-prepared DNA probes were sequentially immobilized on the support surface by microprinting and then hybridized with the fluorescent-labeled samples. And determining the probe position with the strongest fluorescence intensity to obtain a group of probe sequences with complete complementary sequences. Only known genetic variations can be detected, complex Structural Variations (SVs) cannot be detected.
Second generation sequencing technology: the limitations of the reading length and the PCR amplification preference of the existing second-generation sequencing detection technology still have challenges in identifying complex SVs in tumor genomes, and cannot avoid high false negative rate. Second generation sequencing can only identify pathogenic mutations in 35% of patients with familial breast cancer, and most of the remaining familial breast cancers still cannot know the pathogenic gene mutations, so that subsequent risk management cannot be performed.
Third generation whole genome sequencing technology: the second generation sequencing can not obtain the information of the complex Structural Variation (SVs) of the breast cancer gene, but the third generation long-reading long-sequencing technology is used for effectively detecting, and the technology has higher sensibility and specificity in the aspect of detecting the structural variation. At the same time, the detection Single Nucleotide Variation (SNVs) in the gene can be detected. However, the method is a scheme for sequencing the whole genome, so that the breast cancer gene data only occupies a small part, the rest data is meaningless for detecting the breast cancer gene, and the method can complete detection of 1 sample by one or more times of sequencing, so that the time, flux and cost limit the large-scale clinical application of the breast cancer gene detection. And the ultra-large data volume puts extremely high demands on the subsequent data analysis processing capacity.
Disclosure of Invention
In view of the above, the present invention aims to provide a probe composition and a kit for detecting breast cancer genes, wherein the probe set can realize good screening of breast cancer genes by using a three-generation sequencing technology, so that the cost and time required for detection are reduced.
The present invention provides a breast cancer diagnostic probe set comprising probes targeting at least one of the following markers:
ERBB4, RAD51B, ESR1, NF1, FANCC, EGFR, BRIP1, ATM, WRN, ESR2, PGR, BLM, CDH1, MRE11, PIK3CA, RAD50, BRCA2, BARD1, BRCA1, CHEK2, NBS1, RAD51C, ERBB2, RECQL5, PALB2, ERBB3, RAD51D, and RECQL4.
In the invention, in the probe set, the length of each probe is 50-130 bp, and the probe set is designed by referring to human reference genome version Hg 38.
In the present invention, each probe is equally spaced 500bp apart.
The detection probe of the ATM gene targets the space between chr11:108222232 and chr11: 108369359;
the detection probe of the BARD1 gene targets the space between 214725368 and 214809988 of chr2;
the detection probe of the BLM gene targets the range of chr15: 90717185-chr 15: 90816306;
the detection probe of the BRCA1 gene targets the range of chr17: 43044252-chr 17: 43170329;
the detection probe of the BRCA2 gene targets the range of chr13: 32314848-chr13: 32400373;
the detection probe of the BRIP1 gene targets the range of chr17: 61679001-chr 17: 61864121;
the detection probe of the CDH1 gene targets the space between chr16:68737106 and chr16: 68835226;
the detection probe of the CHEK2 gene targets the chr22: 28688022-chr22: 28742642;
the EGFR gene detection probe targets the chr7: 55018762-chr7: 55211883;
the detection probes of the ERBB2 gene target the chr17: 39687609-chr 17: 39730729;
the detection probe of the ERBB3 gene targets the range of chr12: 56078013-chr 12: 56103712;
the detection probe of the ERBB4 gene targets the range of chr2: 211375625-chr2: 212539246;
the detection probe of the ESR1 gene targets the space between chr6:151656594 and chr6: 152129714;
the detection probe of the ESR2 gene targets the range of chr14: 64084565-chr 14: 64338700;
the detection probes of the FANCC genes target the range of chr9: 95098855-chr9: 95426984;
the detection probe of the MRE11 gene targets the range of chr11: 94415321-chr11: 94512441;
the detection probes of the NBS1 genes target the chr8: 89933302-chr8: 90003341;
the detection probe of the NF1 gene targets the range of chr17: 31007684-chr 17: 31382286;
the detection probe of the PALB2 gene targets the space between chr16:23602948 and chr16: 23641568;
the detection probes of the PGR genes target the range of chr11: 101029335-chr11: 101130955;
the detection probe of the PIK3CA gene targets the chr3: 179148043-chr3: 179240163;
the detection probe of the RAD50 gene targets the range of chr5: 132555873-chr5: 132645514;
the detection probe of the RAD51B gene targets the range of chr14: 67819688-chr14: 68730308;
the detection probe of the RAD51C gene targets the range of chr17: 58692263-chr17: 58734994;
the detection probe of the RAD51D gene targets the range of chr17: 35092054-chr17: 35121674;
the detection probe of the RECQL4 gene targets the range of chr8: 144511004-chr8: 144518123;
the detection probe of the RECQL5 gene targets the range of chr17: 75626707-chr17: 75667327;
the detection probes of the WRN genes target the range of chr8: 31033028-chr8: 31175648.
The invention screens the probe sequence, the probe combination with better effect is obtained by screening, and the full coverage screening of the gene variation (SNVs, SVs) of the breast cancer related genes with low cost, high flux and short period is realized by carefully designing the long fragment capturing and amplifying technology of the breast cancer genes and combining the three-generation long reading and long sequencing technology.
The invention also provides a breast cancer diagnostic reagent, which comprises the probe set and a library-building reagent.
The breast cancer diagnosis reagent also comprises a connector A, a connector B and a pre-amplification primer;
the sequence of the joint A is as follows:
gcagtcgaacatgtagctgactcaggtcac(N)xggtagt；
the sequence of the connector B is as follows:
ctacc(N)x gtgacctgagtcagctacatgttcgactgc；
the 5' end of the connector B is modified by phosphorylation, in (N) x, N is any one of A, G, C, T bases, and the number of x is 10-20;
the sequences of the pre-amplification primers are as follows: gcagtcgaacatgtagctgactcaggtcac.
Preferably, the number of x is 16. For the same sample, the (N) x in linker a and linker B are complementary in reverse.
In the invention, the library building reagent comprises: DNA disruption reagent, end repair reagent and adaptor reagent, library pre-amplification reagent, hybridization capture reagent and hybridization elution reagent.
Furthermore, the invention also provides the probe set and application of the breast cancer diagnostic reagent in preparing a breast cancer diagnostic product.
The invention also provides a breast cancer sequencing library construction method, which is constructed by using the breast cancer diagnosis reagent, and specifically comprises the following steps:
after breaking the genome DNA, repairing the tail end, adding the joint A and the joint B to obtain library solution;
the library solution is amplified by the pre-amplification primer, captured by the probe set and then enriched by the magnetic beads.
A breast cancer sequencing library constructed by the construction method as described above.
In the construction method of the invention, the genomic DNA is human genomic DNA. The human genomic DNA is extracted from peripheral blood.
The invention also provides a method for diagnosing breast cancer, which comprises the steps of sequencing a sequencing library obtained by the construction method and analyzing data according to the result.
The sequencing employed Pacbio sequence II.
The data analysis comprises data quality control and splitting, de-duplication, alignment and mutation detection.
The invention realizes the full coverage screening of the gene variation (SNVs, SVs) of the breast cancer related genes with low cost, high flux and short period by carefully designing the long fragment capturing and amplifying technology of the breast cancer genes and combining the three-generation long reading long sequencing technology. The method improves the detection rate of structural variation of breast cancer genes and the clinical accessibility of large-scale screening: 1. the problem of false negative caused by incomplete detection of structural variation of breast cancer genes by a second-generation sequencing detection technology is solved; 2. solves the difficulties of high cost, small flux and inconvenient popularization of the detection of the breast cancer genes by using the three-generation whole genome sequencing, and has remarkable clinical popularization and application values.
Drawings
FIG. 1 shows the structural variation Heat map of 48 samples on different genes;
FIG. 2 shows a 37 base deletion in the RAD50 gene;
FIG. 3 shows the fusion of the RECQL5 gene (chr 17) with the chr7, chr8 genes;
FIG. 4 shows fusion of the FANCC gene (chr 17) with chr 19;
FIG. 5 shows a 25 base deletion in the NF1 gene;
FIG. 6 shows a 148 base deletion of the ERBB4 gene;
FIG. 7 shows BRIP1 gene fusion;
FIG. 8 shows that there are other gene insertions in the RAD51C gene;
FIG. 9 shows that there is a large fragment deletion in the CDH1 gene;
FIG. 10 shows the NF1 gene (chr 17) fused to chr 1;
FIG. 11 shows fusion of ESR1 gene (chr 6) with chr 17;
FIG. 12 shows single base mutations G > A of the PIK3CA gene;
FIG. 13 shows single base mutations A > T of the PIK3CA gene;
FIG. 14 shows insertion of the BLM gene into the A base mutation;
FIG. 15 shows BRCA2 insertion A base mutations;
FIG. 16 shows fusion and transcriptional expression of the RECQL5 gene with the chr8 gene on chr 17.
Detailed Description
The invention provides a probe composition and a kit for breast cancer gene detection, and a person skilled in the art can properly improve the technological parameters by referring to the content of the invention. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and are deemed to be included in the present invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those skilled in the relevant art that the invention can be practiced and practiced with modification and alteration and combination of the methods and applications herein without departing from the spirit and scope of the invention.
The method is characterized in that a capture probe is designed to cover 28 breast cancer related gene areas, and the full-coverage detection of breast cancer genes is realized by combining a three-generation long-reading long-sequencing technology. The 28 breast cancer-associated genes include:
| ERBB4 | RAD51B | ESR1 | NF1 | FANCC | EGFR | BRIP1 |
| ATM | WRN | ESR2 | PGR | BLM | CDH1 | MRE11 |
| PIK3CA | RAD50 | BRCA2 | BARD1 | BRCA1 | CHEK2 | NBS1 |
| RAD51C | ERBB2 | RECQL5 | PALB2 | ERBB3 | RAD51D | RECQL4 |
the probe set is as follows:
ATM：
chr11:108222232-108222352,chr11:108222732-108222852,chr11:108223232-108223352,chr11:108223732-108223852,chr11:108224267-108224387,chr11:108225238-108225358,chr11:108226333-108226453,chr11:108227288-108227408,chr11:108227732-108227852,chr11:108228232-108228352,chr11:108228732-108228852,chr11:108229232-108229352,chr11:108231276-108231396,chr11:108232232-108232352,chr11:108233188-108233308,chr11:108234232-108234352,chr11:108234831-108234951,chr11:108235732-108235852,chr11:108236162-108236282,chr11:108236732-108236852,chr11:108237232-108237352,chr11:108239779-108239899,chr11:108240732-108240852,chr11:108241232-108241352,chr11:108242284-108242404,chr11:108242732-108242852,chr11:108243233-108243353,chr11:108243732-108243852,chr11:108244232-108244352,chr11:108244732-108244852,chr11:108245232-108245352,chr11:108245724-108245844,chr11:108246177-108246297,chr11:108246847-108246967,chr11:108248232-108248352,chr11:108249232-108249352,chr11:108249732-108249852,chr11:108250732-108250852,chr11:108251211-108251331,chr11:108251732-108251852,chr11:108252232-108252352,chr11:108252732-108252852,chr11:108253232-108253352,chr11:108253732-108253852,chr11:108254232-108254352,chr11:108255232-108255352,chr11:108255732-108255852,chr11:108256232-108256352,chr11:108257232-108257352,chr11:108257754-108257874,chr11:108258232-108258352,chr11:108258732-108258852,chr11:108259732-108259852,chr11:108266742-108266862,chr11:108267232-108267352,chr11:108267853-108267973,chr11:108268732-108268852,chr11:108269732-108269852,chr11:108270232-108270352,chr11:108271232-108271352,chr11:108271732-108271852,chr11:108272232-108272352,chr11:108272732-108272852,chr11:108273232-108273352,chr11:108278232-108278352,chr11:108279232-108279352,chr11:108279732-108279852,chr11:108280232-108280352,chr11:108280652-108280772,chr11:108281232-108281352,chr11:108281732-108281852,chr11:108282232-108282352,chr11:108282732-108282852,chr11:108283232-108283352,chr11:108284232-108284352,chr11:108284732-108284852,chr11:108285239-108285359,chr11:108285732-108285852,chr11:108286819-108286939,chr11:108287280-108287400,chr11:108287732-108287852,chr11:108288732-108288852,chr11:108289232-108289352,chr11:108289732-108289852,chr11:108290188-108290308,chr11:108290822-108290942,chr11:108291732-108291852,chr11:108292232-108292352,chr11:108292732-108292852,chr11:108293232-108293352,chr11:108294232-108294352,chr11:108294733-108294853,chr11:108295232-108295352,chr11:108296154-108296274,chr11:108296627-108296747,chr11:108297232-108297352,chr11:108297732-108297852,chr11:108298232-108298352,chr11:108298732-108298852,chr11:108299232-108299352,chr11:108299732-108299852,chr11:108300232-108300352,chr11:108301232-108301352,chr11:108301732-108301852,chr11:108302232-108302352,chr11:108302732-108302852,chr11:108303732-108303852,chr11:108304232-108304352,chr11:108304732-108304852,chr11:108305200-108305320,chr11:108305732-108305852,chr11:108306353-108306473,chr11:108307689-108307809,chr11:108308232-108308352,chr11:108308732-108308852,chr11:108309232-108309352,chr11:108309732-108309852,chr11:108310232-108310352,chr11:108310732-108310852,chr11:108311254-108311374,chr11:108311733-108311853,chr11:108312232-108312352,chr11:108313189-108313309,chr11:108315732-108315852,chr11:108316232-108316352,chr11:108317232-108317352,chr11:108317733-108317853,chr11:108318732-108318852,chr11:108319172-108319292,chr11:108319732-108319852,chr11:108320232-108320352,chr11:108321232-108321352,chr11:108321780-108321900,chr11:108322732-108322852,chr11:108323232-108323352,chr11:108323732-108323852,chr11:108324732-108324852,chr11:108325232-108325352,chr11:108326232-108326352,chr11:108326724-108326844,chr11:108327171-108327291,chr11:108327732-108327852,chr11:108329232-108329352,chr11:108329732-108329852,chr11:108330232-108330352,chr11:108330732-108330852,chr11:108331232-108331352,chr11:108331732-108331852,chr11:108332732-108332852,chr11:108333232-108333352,chr11:108333732-108333852,chr11:108334232-108334352,chr11:108334732-108334852,chr11:108335232-108335352,chr11:108335732-108335852,chr11:108336308-108336428,chr11:108336763-108336883,chr11:108337232-108337352,chr11:108337732-108337852,chr11:108338729-108338849,chr11:108339203-108339323,chr11:108339732-108339852,chr11:108340232-108340352,chr11:108341232-108341352,chr11:108342200-108342320,chr11:108342732-108342852,chr11:108343232-108343352,chr11:108343795-108343915,chr11:108344232-108344352,chr11:108345243-108345363,chr11:108345732-108345852,chr11:108346232-108346352,chr11:108346732-108346852,chr11:108347232-108347352,chr11:108347732-108347852,chr11:108348232-108348352,chr11:108348732-108348852,chr11:108349232-108349352,chr11:108349732-108349852,chr11:108350232-108350352,chr11:108350732-108350852,chr11:108351190-108351310,chr11:108351760-108351880,chr11:108352232-108352352,chr11:108353732-108353852,chr11:108354232-108354352,chr11:108354732-108354852,chr11:108355232-108355352,chr11:108355732-108355852,chr11:108356156-108356276,chr11:108356683-108356803,chr11:108363238-108363358,chr11:108363732-108363852,chr11:108364232-108364352,chr11:108364732-108364852,chr11:108365232-108365352,chr11:108366232-108366352,chr11:108367732-108367852,chr11:108368285-108368405,chr11:108368740-108368860,chr11:108369239-108369359；
BARD1：
chr2:214725368-214725488,chr2:214725868-214725988,chr2:214726368-214726488,chr2:214726868-214726988,chr2:214727368-214727488,chr2:214727868-214727988,chr2:214728368-214728488,chr2:214728868-214728988,chr2:214729419-214729539,chr2:214729868-214729988,chr2:214730368-214730488,chr2:214730868-214730988,chr2:214731368-214731488,chr2:214731868-214731988,chr2:214732299-214732419,chr2:214732868-214732988,chr2:214733868-214733988,chr2:214734368-214734488,chr2:214735868-214735988,chr2:214736368-214736488,chr2:214736868-214736988,chr2:214737368-214737488,chr2:214737868-214737988,chr2:214738368-214738488,chr2:214739368-214739488,chr2:214739868-214739988,chr2:214740368-214740488,chr2:214740868-214740988,chr2:214741369-214741489,chr2:214741868-214741988,chr2:214742368-214742488,chr2:214742868-214742988,chr2:214743319-214743439,chr2:214743934-214744054,chr2:214744368-214744488,chr2:214744910-214745030,chr2:214745368-214745488,chr2:214745868-214745988,chr2:214746368-214746488,chr2:214747869-214747989,chr2:214748368-214748488,chr2:214749368-214749488,chr2:214749868-214749988,chr2:214751442-214751562,chr2:214752369-214752489,chr2:214752868-214752988,chr2:214753368-214753488,chr2:214753874-214753994,chr2:214754369-214754489,chr2:214754868-214754988,chr2:214755391-214755511,chr2:214755868-214755988,chr2:214757368-214757488,chr2:214757868-214757988,chr2:214758368-214758488,chr2:214758868-214758988,chr2:214759368-214759488,chr2:214759868-214759988,chr2:214760472-214760592,chr2:214761404-214761524,chr2:214761868-214761988,chr2:214762369-214762489,chr2:214762954-214763074,chr2:214763868-214763988,chr2:214764345-214764465,chr2:214764868-214764988,chr2:214765302-214765422,chr2:214765868-214765988,chr2:214766368-214766488,chr2:214767368-214767488,chr2:214767868-214767988,chr2:214768368-214768488,chr2:214768868-214768988,chr2:214769362-214769482,chr2:214769868-214769988,chr2:214770368-214770488,chr2:214770868-214770988,chr2:214771350-214771470,chr2:214771923-214772043,chr2:214772368-214772488,chr2:214772868-214772988,chr2:214773322-214773442,chr2:214775868-214775988,chr2:214776368-214776488,chr2:214776868-214776988,chr2:214777368-214777488,chr2:214777819-214777939,chr2:214778368-214778488,chr2:214778868-214778988,chr2:214779480-214779600,chr2:214780368-214780488,chr2:214780868-214780988,chr2:214781368-214781488,chr2:214781868-214781988,chr2:214782868-214782988,chr2:214785329-214785449,chr2:214785816-214785936,chr2:214786368-214786488,chr2:214786868-214786988,chr2:214787368-214787488,chr2:214787868-214787988,chr2:214788368-214788488,chr2:214788868-214788988,chr2:214789868-214789988,chr2:214790368-214790488,chr2:214790868-214790988,chr2:214791368-214791488,chr2:214792368-214792488,chr2:214792868-214792988,chr2:214793388-214793508,chr2:214794368-214794488,chr2:214795368-214795488,chr2:214795868-214795988,chr2:214796368-214796488,chr2:214796968-214797088,chr2:214797868-214797988,chr2:214798368-214798488,chr2:214799368-214799488,chr2:214799868-214799988,chr2:214800305-214800425,chr2:214800907-214801027,chr2:214801368-214801488,chr2:214802474-214802594,chr2:214804368-214804488,chr2:214805368-214805488,chr2:214805868-214805988,chr2:214806390-214806510,chr2:214806872-214806992,chr2:214807368-214807488,chr2:214807868-214807988,chr2:214808410-214808530,chr2:214808868-214808988,chr2:214809368-214809488,chr2:214809868-214809988；
BLM：
chr15:90717185-90717305,chr15:90717685-90717805,chr15:90718685-90718805,chr15:90719743-90719863,chr15:90720263-90720383,chr15:90721185-90721305,chr15:90722631-90722751,chr15:90723188-90723308,chr15:90724268-90724388,chr15:90725228-90725348,chr15:90727293-90727413,chr15:90728722-90728842,chr15:90729682-90729802,chr15:90730162-90730282,chr15:90730762-90730882,chr15:90731242-90731362,chr15:90731722-90731842,chr15:90732202-90732322,chr15:90732682-90732802,chr15:90733162-90733282,chr15:90734697-90734817,chr15:90735177-90735297,chr15:90735729-90735849,chr15:90736167-90736287,chr15:90736685-90736805,chr15:90737239-90737359,chr15:90737685-90737805,chr15:90739671-90739791,chr15:90740185-90740305,chr15:90741305-90741425,chr15:90742185-90742305,chr15:90743258-90743378,chr15:90743686-90743806,chr15:90744185-90744305,chr15:90745085-90745205,chr15:90745685-90745805,chr15:90746267-90746387,chr15:90747186-90747306,chr15:90748186-90748306,chr15:90748656-90748776,chr15:90749186-90749306,chr15:90749686-90749806,chr15:90750186-90750306,chr15:90751186-90751306,chr15:90751686-90751806,chr15:90752686-90752806,chr15:90753686-90753806,chr15:90754186-90754306,chr15:90754686-90754806,chr15:90755187-90755307,chr15:90756725-90756845,chr15:90757186-90757306,chr15:90757686-90757806,chr15:90758686-90758806,chr15:90759182-90759302,chr15:90760186-90760306,chr15:90760686-90760806,chr15:90761186-90761306,chr15:90761661-90761781,chr15:90762162-90762282,chr15:90762687-90762807,chr15:90763186-90763306,chr15:90763697-90763817,chr15:90764133-90764253,chr15:90764686-90764806,chr15:90765186-90765306,chr15:90765686-90765806,chr15:90766186-90766306,chr15:90766707-90766827,chr15:90767186-90767306,chr15:90767686-90767806,chr15:90768617-90768737,chr15:90769186-90769306,chr15:90769793-90769913,chr15:90770686-90770806,chr15:90771108-90771228,chr15:90771694-90771814,chr15:90772186-90772306,chr15:90772686-90772806,chr15:90774186-90774306,chr15:90774804-90774924,chr15:90776186-90776306,chr15:90777570-90777690,chr15:90778186-90778306,chr15:90779298-90779418,chr15:90781164-90781284,chr15:90781768-90781888,chr15:90782744-90782864,chr15:90783186-90783306,chr15:90784686-90784806,chr15:90785170-90785290,chr15:90787570-90787690,chr15:90788592-90788712,chr15:90789186-90789306,chr15:90789686-90789806,chr15:90790186-90790306,chr15:90790686-90790806,chr15:90791186-90791306,chr15:90793769-90793889,chr15:90795098-90795218,chr15:90796236-90796356,chr15:90796686-90796806,chr15:90797686-90797806,chr15:90798186-90798306,chr15:90799187-90799307,chr15:90800249-90800369,chr15:90800686-90800806,chr15:90801187-90801307,chr15:90801678-90801798,chr15:90802186-90802306,chr15:90803187-90803307,chr15:90803686-90803806,chr15:90804186-90804306,chr15:90805140-90805260,chr15:90806686-90806806,chr15:90807185-90807305,chr15:90807665-90807785,chr15:90808186-90808306,chr15:90808766-90808886,chr15:90809186-90809306,chr15:90809686-90809806,chr15:90810686-90810806,chr15:90811186-90811306,chr15:90812186-90812306,chr15:90812686-90812806,chr15:90813186-90813306,chr15:90813686-90813806,chr15:90814186-90814306,chr15:90814686-90814806,chr15:90815186-90815306,chr15:90815629-90815749,chr15:90816186-90816306；
BRCA1：
chr17:43044252-43044372,chr17:43044690-43044810,chr17:43045209-43045329,chr17:43045709-43045829,chr17:43046753-43046873,chr17:43047645-43047765,chr17:43048797-43048917,chr17:43049709-43049829,chr17:43050209-43050329,chr17:43050709-43050829,chr17:43051209-43051329,chr17:43052683-43052803,chr17:43053209-43053329,chr17:43054209-43054329,chr17:43055209-43055329,chr17:43056102-43056222,chr17:43057130-43057250,chr17:43058709-43058829,chr17:43059742-43059862,chr17:43061125-43061245,chr17:43063209-43063329,chr17:43063709-43063829,chr17:43064209-43064329,chr17:43064709-43064829,chr17:43065209-43065329,chr17:43065741-43065861,chr17:43066210-43066330,chr17:43066710-43066830,chr17:43067141-43067261,chr17:43067666-43067786,chr17:43068709-43068829,chr17:43069209-43069329,chr17:43069709-43069829,chr17:43070212-43070332,chr17:43070709-43070829,chr17:43071209-43071329,chr17:43073209-43073329,chr17:43073640-43073760,chr17:43074209-43074329,chr17:43074675-43074795,chr17:43075209-43075329,chr17:43075709-43075829,chr17:43076209-43076329,chr17:43076709-43076829,chr17:43077209-43077329,chr17:43078709-43078829,chr17:43081209-43081329,chr17:43081709-43081829,chr17:43082209-43082329,chr17:43082709-43082829,chr17:43083709-43083829,chr17:43084709-43084829,chr17:43085160-43085280,chr17:43085709-43085829,chr17:43086209-43086329,chr17:43086709-43086829,chr17:43087237-43087357,chr17:43088709-43088829,chr17:43089313-43089433,chr17:43090255-43090375,chr17:43090709-43090829,chr17:43091209-43091329,chr17:43091709-43091829,chr17:43092209-43092329,chr17:43092709-43092829,chr17:43093209-43093329,chr17:43093709-43093829,chr17:43094209-43094329,chr17:43094709-43094829,chr17:43095202-43095322,chr17:43095709-43095829,chr17:43096709-43096829,chr17:43097209-43097329,chr17:43097826-43097946,chr17:43098277-43098397,chr17:43099162-43099282,chr17:43099709-43099829,chr17:43100209-43100329,chr17:43101094-43101214,chr17:43101781-43101901,chr17:43103049-43103169,chr17:43103709-43103829,chr17:43104209-43104329,chr17:43104710-43104830,chr17:43105137-43105257,chr17:43105598-43105718,chr17:43106209-43106329,chr17:43107791-43107911,chr17:43108329-43108449,chr17:43109276-43109396,chr17:43109701-43109821,chr17:43110142-43110262,chr17:43110594-43110714,chr17:43111154-43111274,chr17:43112702-43112822,chr17:43113209-43113329,chr17:43113704-43113824,chr17:43114211-43114331,chr17:43114709-43114829,chr17:43115709-43115829,chr17:43116714-43116834,chr17:43117746-43117866,chr17:43119265-43119385,chr17:43119709-43119829,chr17:43120209-43120329,chr17:43121742-43121862,chr17:43122209-43122329,chr17:43123215-43123335,chr17:43123709-43123829,chr17:43124209-43124329,chr17:43124653-43124773,chr17:43125209-43125329,chr17:43125709-43125829,chr17:43126209-43126329,chr17:43128709-43128829,chr17:43129209-43129329,chr17:43129752-43129872,chr17:43131209-43131329,chr17:43132209-43132329,chr17:43133209-43133329,chr17:43134209-43134329,chr17:43134709-43134829,chr17:43135209-43135329,chr17:43135709-43135829,chr17:43138210-43138330,chr17:43138709-43138829,chr17:43140787-43140907,chr17:43141210-43141330,chr17:43141782-43141902,chr17:43142207-43142327,chr17:43143220-43143340,chr17:43143709-43143829,chr17:43144217-43144337,chr17:43144641-43144761,chr17:43146709-43146829,chr17:43147709-43147829,chr17:43148714-43148834,chr17:43149652-43149772,chr17:43150709-43150829,chr17:43151205-43151325,chr17:43151709-43151829,chr17:43152184-43152304,chr17:43153042-43153162,chr17:43154709-43154829,chr17:43155802-43155922,chr17:43156238-43156358,chr17:43156709-43156829,chr17:43157209-43157329,chr17:43158209-43158329,chr17:43159839-43159959,chr17:43167780-43167900,chr17:43168209-43168329,chr17:43168709-43168829,chr17:43169709-43169829,chr17:43170209-43170329；
BRCA2：
chr13:32314848-32314968,chr13:32315753-32315873,chr13:32316271-32316391,chr13:32316698-32316818,chr13:32317174-32317294,chr13:32317753-32317873,chr13:32318254-32318374,chr13:32318754-32318874,chr13:32319237-32319357,chr13:32319724-32319844,chr13:32320245-32320365,chr13:32320745-32320865,chr13:32321753-32321873,chr13:32323753-32323873,chr13:32325253-32325373,chr13:32325819-32325939,chr13:32326253-32326373,chr13:32326753-32326873,chr13:32327670-32327790,chr13:32328782-32328902,chr13:32329253-32329373,chr13:32330253-32330373,chr13:32330842-32330962,chr13:32331701-32331821,chr13:32332253-32332373,chr13:32332753-32332873,chr13:32333253-32333373,chr13:32334254-32334374,chr13:32334753-32334873,chr13:32335343-32335463,chr13:32336253-32336373,chr13:32336753-32336873,chr13:32337253-32337373,chr13:32337753-32337873,chr13:32338253-32338373,chr13:32338753-32338873,chr13:32339253-32339373,chr13:32339753-32339873,chr13:32340253-32340373,chr13:32340753-32340873,chr13:32341253-32341373,chr13:32341860-32341980,chr13:32342336-32342456,chr13:32343253-32343373,chr13:32343753-32343873,chr13:32344253-32344373,chr13:32345311-32345431,chr13:32346253-32346373,chr13:32346753-32346873,chr13:32347253-32347373,chr13:32347753-32347873,chr13:32348253-32348373,chr13:32348731-32348851,chr13:32349211-32349331,chr13:32349811-32349931,chr13:32350291-32350411,chr13:32350771-32350891,chr13:32351699-32351819,chr13:32352253-32352373,chr13:32352753-32352873,chr13:32353709-32353829,chr13:32354253-32354373,chr13:32354753-32354873,chr13:32355253-32355373,chr13:32356349-32356469,chr13:32357268-32357388,chr13:32357753-32357873,chr13:32359254-32359374,chr13:32359735-32359855,chr13:32360188-32360308,chr13:32360753-32360873,chr13:32361253-32361373,chr13:32361843-32361963,chr13:32362308-32362428,chr13:32362753-32362873,chr13:32363253-32363373,chr13:32363753-32363873,chr13:32364753-32364873,chr13:32365281-32365401,chr13:32365726-32365846,chr13:32366253-32366373,chr13:32366806-32366926,chr13:32368701-32368821,chr13:32369253-32369373,chr13:32370253-32370373,chr13:32370872-32370992,chr13:32371619-32371739,chr13:32376142-32376262,chr13:32376753-32376873,chr13:32377212-32377332,chr13:32377753-32377873,chr13:32378253-32378373,chr13:32378741-32378861,chr13:32379253-32379373,chr13:32379753-32379873,chr13:32380253-32380373,chr13:32381253-32381373,chr13:32381760-32381880,chr13:32382240-32382360,chr13:32382753-32382873,chr13:32383320-32383440,chr13:32383753-32383873,chr13:32384253-32384373,chr13:32384753-32384873,chr13:32385253-32385373,chr13:32385753-32385873,chr13:32386743-32386863,chr13:32388646-32388766,chr13:32389169-32389289,chr13:32389753-32389873,chr13:32390212-32390332,chr13:32390753-32390873,chr13:32391753-32391873,chr13:32392253-32392373,chr13:32392753-32392873,chr13:32393253-32393373,chr13:32393746-32393866,chr13:32394253-32394373,chr13:32394753-32394873,chr13:32395253-32395373,chr13:32395753-32395873,chr13:32396275-32396395,chr13:32396753-32396873,chr13:32397253-32397373,chr13:32397796-32397916,chr13:32398253-32398373,chr13:32398753-32398873,chr13:32399253-32399373,chr13:32399687-32399807,chr13:32400253-32400373；
BRIP1：
chr17:61679001-61679121,chr17:61679501-61679621,chr17:61679963-61680083,chr17:61681527-61681647,chr17:61682001-61682121,chr17:61682501-61682621,chr17:61683121-61683241,chr17:61684001-61684121,chr17:61685268-61685388,chr17:61686001-61686121,chr17:61686501-61686621,chr17:61686996-61687116,chr17:61687501-61687621,chr17:61687948-61688068,chr17:61689501-61689621,chr17:61692501-61692621,chr17:61693501-61693621,chr17:61695501-61695621,chr17:61696979-61697099,chr17:61698501-61698621,chr17:61699499-61699619,chr17:61699979-61700099,chr17:61700501-61700621,chr17:61701001-61701121,chr17:61701501-61701621,chr17:61702001-61702121,chr17:61705499-61705619,chr17:61706459-61706579,chr17:61707001-61707121,chr17:61707501-61707621,chr17:61708019-61708139,chr17:61708492-61708612,chr17:61709001-61709121,chr17:61709501-61709621,chr17:61710001-61710121,chr17:61710514-61710634,chr17:61711489-61711609,chr17:61712016-61712136,chr17:61712502-61712622,chr17:61715501-61715621,chr17:61716001-61716121,chr17:61717501-61717621,chr17:61718001-61718121,chr17:61718501-61718621,chr17:61719090-61719210,chr17:61720410-61720530,chr17:61721121-61721241,chr17:61721548-61721668,chr17:61722501-61722621,chr17:61723001-61723121,chr17:61723501-61723621,chr17:61724002-61724122,chr17:61724501-61724621,chr17:61725001-61725121,chr17:61725501-61725621,chr17:61725997-61726117,chr17:61726501-61726621,chr17:61727001-61727121,chr17:61728108-61728228,chr17:61728919-61729039,chr17:61729556-61729676,chr17:61730001-61730121,chr17:61730501-61730621,chr17:61731001-61731121,chr17:61731910-61732030,chr17:61732432-61732552,chr17:61733002-61733122,chr17:61733501-61733621,chr17:61734053-61734173,chr17:61734501-61734621,chr17:61735001-61735121,chr17:61736501-61736621,chr17:61737001-61737121,chr17:61737564-61737684,chr17:61738001-61738121,chr17:61738501-61738621,chr17:61739001-61739121,chr17:61739501-61739621,chr17:61740001-61740121,chr17:61740471-61740591,chr17:61743001-61743121,chr17:61743501-61743621,chr17:61744001-61744121,chr17:61744501-61744621,chr17:61745001-61745121,chr17:61746001-61746121,chr17:61746501-61746621,chr17:61747001-61747121,chr17:61748501-61748621,chr17:61750501-61750621,chr17:61751557-61751677,chr17:61752501-61752621,chr17:61753001-61753121,chr17:61753477-61753597,chr17:61754001-61754121,chr17:61754437-61754557,chr17:61755559-61755679,chr17:61756001-61756121,chr17:61756501-61756621,chr17:61757001-61757121,chr17:61757501-61757621,chr17:61758003-61758123,chr17:61758480-61758600,chr17:61763501-61763621,chr17:61763929-61764049,chr17:61764496-61764616,chr17:61765001-61765121,chr17:61766001-61766121,chr17:61766501-61766621,chr17:61767001-61767121,chr17:61768001-61768121,chr17:61768501-61768621,chr17:61769001-61769121,chr17:61769501-61769621,chr17:61770001-61770121,chr17:61770501-61770621,chr17:61773001-61773121,chr17:61774613-61774733,chr17:61775501-61775621,chr17:61776501-61776621,chr17:61776982-61777102,chr17:61777501-61777621,chr17:61778501-61778621,chr17:61779001-61779121,chr17:61780001-61780121,chr17:61781001-61781121,chr17:61781501-61781621,chr17:61781970-61782090,chr17:61783001-61783121,chr17:61783562-61783682,chr17:61784066-61784186,chr17:61785001-61785121,chr17:61785501-61785621,chr17:61786001-61786121,chr17:61786474-61786594,chr17:61787527-61787647,chr17:61788007-61788127,chr17:61788487-61788607,chr17:61789483-61789603,chr17:61789960-61790080,chr17:61791001-61791121,chr17:61791531-61791651,chr17:61793501-61793621,chr17:61794001-61794121,chr17:61797001-61797121,chr17:61797538-61797658,chr17:61798001-61798121,chr17:61798502-61798622,chr17:61799001-61799121,chr17:61799501-61799621,chr17:61800001-61800121,chr17:61800501-61800621,chr17:61801001-61801121,chr17:61801501-61801621,chr17:61801958-61802078,chr17:61802502-61802622,chr17:61803611-61803731,chr17:61805086-61805206,chr17:61806001-61806121,chr17:61806501-61806621,chr17:61807001-61807121,chr17:61807501-61807621,chr17:61808001-61808121,chr17:61808501-61808621,chr17:61809001-61809121,chr17:61809501-61809621,chr17:61810001-61810121,chr17:61810501-61810621,chr17:61811001-61811121,chr17:61811502-61811622,chr17:61812001-61812121,chr17:61812501-61812621,chr17:61813001-61813121,chr17:61813501-61813621,chr17:61814001-61814121,chr17:61814501-61814621,chr17:61815001-61815121,chr17:61815501-61815621,chr17:61816001-61816121,chr17:61816501-61816621,chr17:61817461-61817581,chr17:61818501-61818621,chr17:61820014-61820134,chr17:61820465-61820585,chr17:61822008-61822128,chr17:61822501-61822621,chr17:61823001-61823121,chr17:61823501-61823621,chr17:61824091-61824211,chr17:61829001-61829121,chr17:61829501-61829621,chr17:61830501-61830621,chr17:61831001-61831121,chr17:61832001-61832121,chr17:61832501-61832621,chr17:61833001-61833121,chr17:61833501-61833621,chr17:61834092-61834212,chr17:61835001-61835121,chr17:61835501-61835621,chr17:61836001-61836121,chr17:61836462-61836582,chr17:61837057-61837177,chr17:61837501-61837621,chr17:61838001-61838121,chr17:61838573-61838693,chr17:61839001-61839121,chr17:61839501-61839621,chr17:61839979-61840099,chr17:61841501-61841621,chr17:61842575-61842695,chr17:61843501-61843621,chr17:61844590-61844710,chr17:61845081-61845201,chr17:61847001-61847121,chr17:61847501-61847621,chr17:61848001-61848121,chr17:61848502-61848622,chr17:61849001-61849121,chr17:61849501-61849621,chr17:61850001-61850121,chr17:61851501-61851621,chr17:61852047-61852167,chr17:61853001-61853121,chr17:61853497-61853617,chr17:61855001-61855121,chr17:61856101-61856221,chr17:61857001-61857121,chr17:61858001-61858121,chr17:61859054-61859174,chr17:61860001-61860121,chr17:61861002-61861122,chr17:61861501-61861621,chr17:61862001-61862121,chr17:61862613-61862733,chr17:61863501-61863621,chr17:61864001-61864121；
CDH1：
chr16:68737106-68737226,chr16:68737606-68737726,chr16:68738106-68738226,chr16:68738586-68738706,chr16:68740106-68740226,chr16:68740606-68740726,chr16:68741106-68741226,chr16:68741589-68741709,chr16:68742106-68742226,chr16:68742700-68742820,chr16:68743645-68743765,chr16:68744106-68744226,chr16:68744550-68744670,chr16:68745106-68745226,chr16:68745616-68745736,chr16:68746568-68746688,chr16:68747038-68747158,chr16:68748711-68748831,chr16:68750106-68750226,chr16:68750606-68750726,chr16:68751106-68751226,chr16:68752606-68752726,chr16:68753212-68753332,chr16:68754607-68754727,chr16:68755606-68755726,chr16:68756106-68756226,chr16:68756606-68756726,chr16:68757531-68757651,chr16:68758099-68758219,chr16:68758607-68758727,chr16:68760606-68760726,chr16:68761106-68761226,chr16:68762496-68762616,chr16:68763106-68763226,chr16:68763606-68763726,chr16:68764106-68764226,chr16:68764607-68764727,chr16:68765089-68765209,chr16:68765606-68765726,chr16:68767092-68767212,chr16:68767658-68767778,chr16:68768225-68768345,chr16:68769196-68769316,chr16:68770164-68770284,chr16:68770606-68770726,chr16:68771106-68771226,chr16:68772106-68772226,chr16:68773066-68773186,chr16:68774606-68774726,chr16:68775131-68775251,chr16:68775606-68775726,chr16:68776648-68776768,chr16:68777106-68777226,chr16:68778606-68778726,chr16:68779106-68779226,chr16:68780106-68780226,chr16:68780619-68780739,chr16:68781106-68781226,chr16:68782106-68782226,chr16:68782607-68782727,chr16:68783571-68783691,chr16:68784221-68784341,chr16:68785095-68785215,chr16:68786073-68786193,chr16:68786606-68786726,chr16:68787106-68787226,chr16:68788107-68788227,chr16:68788607-68788727,chr16:68790106-68790226,chr16:68790606-68790726,chr16:68791106-68791226,chr16:68791706-68791826,chr16:68792606-68792726,chr16:68793106-68793226,chr16:68795106-68795226,chr16:68796162-68796282,chr16:68796606-68796726,chr16:68797683-68797803,chr16:68798107-68798227,chr16:68798606-68798726,chr16:68799180-68799300,chr16:68799606-68799726,chr16:68800175-68800295,chr16:68801012-68801132,chr16:68801606-68801726,chr16:68802181-68802301,chr16:68803106-68803226,chr16:68803674-68803794,chr16:68804606-68804726,chr16:68805038-68805158,chr16:68806429-68806549,chr16:68807106-68807226,chr16:68807694-68807814,chr16:68808606-68808726,chr16:68809106-68809226,chr16:68810106-68810226,chr16:68811606-68811726,chr16:68812106-68812226,chr16:68812644-68812764,chr16:68813211-68813331,chr16:68814606-68814726,chr16:68815223-68815343,chr16:68817106-68817226,chr16:68817606-68817726,chr16:68819135-68819255,chr16:68820189-68820309,chr16:68820675-68820795,chr16:68821606-68821726,chr16:68822106-68822226,chr16:68822606-68822726,chr16:68823106-68823226,chr16:68823606-68823726,chr16:68824606-68824726,chr16:68825606-68825726,chr16:68826106-68826226,chr16:68826606-68826726,chr16:68827106-68827226,chr16:68827563-68827683,chr16:68828106-68828226,chr16:68828607-68828727,chr16:68829106-68829226,chr16:68829606-68829726,chr16:68830519-68830639,chr16:68833106-68833226,chr16:68833606-68833726,chr16:68834606-68834726,chr16:68835106-68835226；
CHEK2：
chr22:28688022-28688142,chr22:28689022-28689142,chr22:28689522-28689642,chr22:28690022-28690142,chr22:28691022-28691142,chr22:28692022-28692142,chr22:28692522-28692642,chr22:28693069-28693189,chr22:28693522-28693642,chr22:28694022-28694142,chr22:28694522-28694642,chr22:28695022-28695142,chr22:28695627-28695747,chr22:28696638-28696758,chr22:28697459-28697579,chr22:28697929-28698049,chr22:28698522-28698642,chr22:28699641-28699761,chr22:28700494-28700614,chr22:28701067-28701187,chr22:28701522-28701642,chr22:28703522-28703642,chr22:28704022-28704142,chr22:28704610-28704730,chr22:28705500-28705620,chr22:28707022-28707142,chr22:28707522-28707642,chr22:28708114-28708234,chr22:28709022-28709142,chr22:28709510-28709630,chr22:28710022-28710142,chr22:28710522-28710642,chr22:28711022-28711142,chr22:28711603-28711723,chr22:28712522-28712642,chr22:28714522-28714642,chr22:28716522-28716642,chr22:28718072-28718192,chr22:28719022-28719142,chr22:28719522-28719642,chr22:28719984-28720104,chr22:28720522-28720642,chr22:28721022-28721142,chr22:28721558-28721678,chr22:28722037-28722157,chr22:28722549-28722669,chr22:28723022-28723142,chr22:28723526-28723646,chr22:28724023-28724143,chr22:28724472-28724592,chr22:28725022-28725142,chr22:28725481-28725601,chr22:28726626-28726746,chr22:28727468-28727588,chr22:28728068-28728188,chr22:28729028-28729148,chr22:28730541-28730661,chr22:28731578-28731698,chr22:28732526-28732646,chr22:28733070-28733190,chr22:28733952-28734072,chr22:28734522-28734642,chr22:28735022-28735142,chr22:28735934-28736054,chr22:28736522-28736642,chr22:28737017-28737137,chr22:28738523-28738643,chr22:28741522-28741642,chr22:28742022-28742142,chr22:28742522-28742642；
EGFR：
chr7:55018762-55018882,chr7:55019262-55019382,chr7:55019762-55019882,chr7:55020262-55020382,chr7:55020744-55020864,chr7:55021262-55021382,chr7:55021689-55021809,chr7:55022262-55022382,chr7:55022762-55022882,chr7:55023262-55023382,chr7:55023762-55023882,chr7:55024262-55024382,chr7:55024762-55024882,chr7:55025262-55025382,chr7:55025762-55025882,chr7:55026251-55026371,chr7:55027262-55027382,chr7:55027762-55027882,chr7:55028262-55028382,chr7:55028762-55028882,chr7:55029262-55029382,chr7:55029762-55029882,chr7:55030262-55030382,chr7:55030762-55030882,chr7:55031262-55031382,chr7:55031762-55031882,chr7:55032262-55032382,chr7:55032762-55032882,chr7:55033262-55033382,chr7:55033762-55033882,chr7:55034762-55034882,chr7:55035262-55035382,chr7:55035696-55035816,chr7:55036279-55036399,chr7:55036762-55036882,chr7:55037262-55037382,chr7:55037800-55037920,chr7:55038263-55038383,chr7:55038849-55038969,chr7:55039762-55039882,chr7:55040262-55040382,chr7:55040762-55040882,chr7:55041762-55041882,chr7:55042262-55042382,chr7:55042762-55042882,chr7:55043762-55043882,chr7:55044262-55044382,chr7:55044811-55044931,chr7:55045262-55045382,chr7:55046262-55046382,chr7:55046841-55046961,chr7:55047262-55047382,chr7:55047763-55047883,chr7:55048262-55048382,chr7:55048762-55048882,chr7:55049262-55049382,chr7:55049762-55049882,chr7:55050762-55050882,chr7:55052262-55052382,chr7:55052762-55052882,chr7:55053262-55053382,chr7:55053762-55053882,chr7:55054262-55054382,chr7:55054762-55054882,chr7:55055363-55055483,chr7:55056262-55056382,chr7:55057286-55057406,chr7:55057762-55057882,chr7:55058831-55058951,chr7:55059762-55059882,chr7:55060262-55060382,chr7:55060762-55060882,chr7:55061262-55061382,chr7:55061762-55061882,chr7:55062262-55062382,chr7:55062762-55062882,chr7:55063262-55063382,chr7:55063762-55063882,chr7:55064262-55064382,chr7:55064762-55064882,chr7:55065262-55065382,chr7:55065762-55065882,chr7:55066262-55066382,chr7:55066762-55066882,chr7:55067262-55067382,chr7:55068262-55068382,chr7:55068762-55068882,chr7:55069262-55069382,chr7:55069762-55069882,chr7:55070262-55070382,chr7:55070762-55070882,chr7:55071262-55071382,chr7:55071762-55071882,chr7:55072235-55072355,chr7:55072762-55072882,chr7:55073356-55073476,chr7:55074262-55074382,chr7:55074762-55074882,chr7:55075262-55075382,chr7:55075762-55075882,chr7:55076262-55076382,chr7:55076762-55076882,chr7:55077262-55077382,chr7:55077762-55077882,chr7:55078262-55078382,chr7:55078762-55078882,chr7:55079262-55079382,chr7:55079762-55079882,chr7:55080234-55080354,chr7:55080813-55080933,chr7:55081262-55081382,chr7:55081762-55081882,chr7:55082262-55082382,chr7:55083262-55083382,chr7:55083762-55083882,chr7:55084262-55084382,chr7:55084782-55084902,chr7:55085262-55085382,chr7:55085762-55085882,chr7:55086263-55086383,chr7:55086762-55086882,chr7:55087260-55087380,chr7:55087762-55087882,chr7:55088262-55088382,chr7:55088762-55088882,chr7:55089262-55089382,chr7:55089762-55089882,chr7:55090262-55090382,chr7:55090762-55090882,chr7:55091262-55091382,chr7:55091750-55091870,chr7:55092262-55092382,chr7:55092762-55092882,chr7:55093262-55093382,chr7:55093762-55093882,chr7:55094262-55094382,chr7:55094762-55094882,chr7:55095323-55095443,chr7:55096262-55096382,chr7:55096762-55096882,chr7:55097262-55097382,chr7:55097762-55097882,chr7:55098262-55098382,chr7:55098762-55098882,chr7:55099262-55099382,chr7:55099762-55099882,chr7:55100262-55100382,chr7:55100736-55100856,chr7:55101262-55101382,chr7:55101860-55101980,chr7:55102762-55102882,chr7:55103262-55103382,chr7:55103762-55103882,chr7:55104262-55104382,chr7:55104762-55104882,chr7:55105262-55105382,chr7:55105762-55105882,chr7:55106262-55106382,chr7:55106762-55106882,chr7:55107262-55107382,chr7:55107762-55107882,chr7:55108262-55108382,chr7:55109262-55109382,chr7:55109762-55109882,chr7:55110262-55110382,chr7:55110762-55110882,chr7:55111262-55111382,chr7:55111762-55111882,chr7:55112262-55112382,chr7:55112845-55112965,chr7:55113762-55113882,chr7:55114762-55114882,chr7:55115262-55115382,chr7:55115762-55115882,chr7:55116262-55116382,chr7:55116762-55116882,chr7:55117262-55117382,chr7:55117762-55117882,chr7:55118357-55118477,chr7:55119262-55119382,chr7:55119756-55119876,chr7:55120262-55120382,chr7:55120762-55120882,chr7:55121262-55121382,chr7:55121762-55121882,chr7:55122262-55122382,chr7:55122762-55122882,chr7:55123262-55123382,chr7:55123730-55123850,chr7:55124262-55124382,chr7:55124762-55124882,chr7:55125262-55125382,chr7:55125841-55125961,chr7:55126762-55126882,chr7:55127262-55127382,chr7:55127762-55127882,chr7:55128262-55128382,chr7:55128762-55128882,chr7:55129225-55129345,chr7:55129653-55129773,chr7:55130262-55130382,chr7:55130762-55130882,chr7:55131262-55131382,chr7:55131762-55131882,chr7:55132262-55132382,chr7:55132762-55132882,chr7:55133262-55133382,chr7:55133762-55133882,chr7:55134262-55134382,chr7:55134737-55134857,chr7:55135262-55135382,chr7:55135762-55135882,chr7:55136262-55136382,chr7:55137262-55137382,chr7:55137762-55137882,chr7:55138262-55138382,chr7:55139276-55139396,chr7:55139762-55139882,chr7:55140262-55140382,chr7:55140762-55140882,chr7:55141262-55141382,chr7:55141762-55141882,chr7:55142262-55142382,chr7:55142796-55142916,chr7:55143262-55143382,chr7:55143762-55143882,chr7:55144306-55144426,chr7:55145262-55145382,chr7:55145714-55145834,chr7:55146221-55146341,chr7:55146762-55146882,chr7:55147262-55147382,chr7:55147762-55147882,chr7:55148262-55148382,chr7:55148762-55148882,chr7:55149234-55149354,chr7:55149857-55149977,chr7:55150762-55150882,chr7:55151262-55151382,chr7:55151881-55152001,chr7:55152700-55152820,chr7:55153262-55153382,chr7:55153762-55153882,chr7:55154262-55154382,chr7:55154762-55154882,chr7:55155762-55155882,chr7:55156262-55156382,chr7:55156762-55156882,chr7:55157323-55157443,chr7:55158262-55158382,chr7:55158762-55158882,chr7:55159262-55159382,chr7:55159768-55159888,chr7:55160262-55160382,chr7:55161262-55161382,chr7:55161762-55161882,chr7:55162262-55162382,chr7:55162696-55162816,chr7:55163262-55163382,chr7:55163762-55163882,chr7:55164262-55164382,chr7:55164762-55164882,chr7:55165262-55165382,chr7:55165762-55165882,chr7:55166259-55166379,chr7:55166762-55166882,chr7:55167743-55167863,chr7:55168262-55168382,chr7:55168762-55168882,chr7:55169762-55169882,chr7:55170262-55170382,chr7:55170762-55170882,chr7:55171262-55171382,chr7:55171762-55171882,chr7:55172262-55172382,chr7:55172762-55172882,chr7:55173262-55173382,chr7:55173762-55173882,chr7:55174262-55174382,chr7:55174762-55174882,chr7:55175262-55175382,chr7:55175762-55175882,chr7:55176262-55176382,chr7:55177262-55177382,chr7:55177762-55177882,chr7:55178262-55178382,chr7:55178762-55178882,chr7:55179362-55179482,chr7:55180262-55180382,chr7:55180762-55180882,chr7:55181262-55181382,chr7:55181762-55181882,chr7:55182262-55182382,chr7:55182762-55182882,chr7:55183762-55183882,chr7:55184262-55184382,chr7:55184762-55184882,chr7:55185262-55185382,chr7:55185762-55185882,chr7:55186262-55186382,chr7:55186762-55186882,chr7:55187241-55187361,chr7:55187762-55187882,chr7:55188262-55188382,chr7:55188762-55188882,chr7:55189262-55189382,chr7:55189821-55189941,chr7:55190262-55190382,chr7:55190762-55190882,chr7:55191262-55191382,chr7:55191762-55191882,chr7:55192262-55192382,chr7:55192762-55192882,chr7:55193262-55193382,chr7:55193762-55193882,chr7:55194762-55194882,chr7:55195262-55195382,chr7:55198262-55198382,chr7:55198762-55198882,chr7:55199262-55199382,chr7:55199762-55199882,chr7:55200262-55200382,chr7:55201262-55201382,chr7:55201762-55201882,chr7:55202305-55202425,chr7:55202762-55202882,chr7:55203788-55203908,chr7:55205262-55205382,chr7:55205762-55205882,chr7:55206262-55206382,chr7:55206762-55206882,chr7:55207262-55207382,chr7:55207762-55207882,chr7:55208262-55208382,chr7:55208762-55208882,chr7:55209262-55209382,chr7:55209762-55209882,chr7:55210262-55210382,chr7:55210762-55210882,chr7:55211262-55211382,chr7:55211763-55211883；
ERBB2：
chr17:39687609-39687729,chr17:39688109-39688229,chr17:39688610-39688730,chr17:39689109-39689229,chr17:39689990-39690110,chr17:39690609-39690729,chr17:39691034-39691154,chr17:39691602-39691722,chr17:39692202-39692322,chr17:39692682-39692802,chr17:39694609-39694729,chr17:39695109-39695229,chr17:39695607-39695727,chr17:39696109-39696229,chr17:39697109-39697229,chr17:39698160-39698280,chr17:39698609-39698729,chr17:39699080-39699200,chr17:39700109-39700229,chr17:39700609-39700729,chr17:39701107-39701227,chr17:39701609-39701729,chr17:39703109-39703229,chr17:39703609-39703729,chr17:39704158-39704278,chr17:39704609-39704729,chr17:39705157-39705277,chr17:39705609-39705729,chr17:39706109-39706229,chr17:39706609-39706729,chr17:39707109-39707229,chr17:39707601-39707721,chr17:39708219-39708339,chr17:39709109-39709229,chr17:39709609-39709729,chr17:39710109-39710229,chr17:39710549-39710669,chr17:39711526-39711646,chr17:39712109-39712229,chr17:39712603-39712723,chr17:39714109-39714229,chr17:39714617-39714737,chr17:39715109-39715229,chr17:39715609-39715729,chr17:39716109-39716229,chr17:39716609-39716729,chr17:39717109-39717229,chr17:39717609-39717729,chr17:39718110-39718230,chr17:39718648-39718768,chr17:39719552-39719672,chr17:39720058-39720178,chr17:39720553-39720673,chr17:39721577-39721697,chr17:39722648-39722768,chr17:39723109-39723229,chr17:39723609-39723729,chr17:39724609-39724729,chr17:39725109-39725229,chr17:39725609-39725729,chr17:39726609-39726729,chr17:39727109-39727229,chr17:39727609-39727729,chr17:39728109-39728229,chr17:39728609-39728729,chr17:39729109-39729229,chr17:39729609-39729729,chr17:39730109-39730229,chr17:39730609-39730729；
ERBB3：
chr12:56078013-56078133,chr12:56078687-56078807,chr12:56079592-56079712,chr12:56080092-56080212,chr12:56080592-56080712,chr12:56081119-56081239,chr12:56081592-56081712,chr12:56082092-56082212,chr12:56082592-56082712,chr12:56083092-56083212,chr12:56083592-56083712,chr12:56084092-56084212,chr12:56085092-56085212,chr12:56086093-56086213,chr12:56086592-56086712,chr12:56087134-56087254,chr12:56087592-56087712,chr12:56088092-56088212,chr12:56088592-56088712,chr12:56091618-56091738,chr12:56092687-56092807,chr12:56093592-56093712,chr12:56094092-56094212,chr12:56094572-56094692,chr12:56095092-56095212,chr12:56095592-56095712,chr12:56096183-56096303,chr12:56097092-56097212,chr12:56097673-56097793,chr12:56098592-56098712,chr12:56099593-56099713,chr12:56100092-56100212,chr12:56101092-56101212,chr12:56101592-56101712,chr12:56102092-56102212,chr12:56103092-56103212,chr12:56103592-56103712；
ERBB4：
chr2:211375625-211375745,chr2:211376125-211376245,chr2:211376625-211376745,chr2:211377125-211377245,chr2:211377625-211377745,chr2:211378125-211378245,chr2:211378625-211378745,chr2:211379125-211379245,chr2:211379625-211379745,chr2:211380125-211380245,chr2:211380625-211380745,chr2:211381125-211381245,chr2:211381625-211381745,chr2:211382125-211382245,chr2:211382625-211382745,chr2:211383125-211383245,chr2:211383625-211383745,chr2:211384125-211384245,chr2:211384625-211384745,chr2:211385125-211385245,chr2:211385625-211385745,chr2:211386125-211386245,chr2:211386702-211386822,chr2:211387125-211387245,chr2:211387625-211387745,chr2:211388125-211388245,chr2:211388625-211388745,chr2:211389125-211389245,chr2:211389593-211389713,chr2:211390091-211390211,chr2:211390625-211390745,chr2:211391125-211391245,chr2:211391625-211391745,chr2:211392125-211392245,chr2:211393125-211393245,chr2:211393625-211393745,chr2:211394125-211394245,chr2:211394625-211394745,chr2:211395125-211395245,chr2:211395625-211395745,chr2:211396192-211396312,chr2:211396625-211396745,chr2:211397125-211397245,chr2:211397625-211397745,chr2:211399125-211399245,chr2:211399625-211399745,chr2:211400070-211400190,chr2:211401125-211401245,chr2:211401625-211401745,chr2:211402625-211402745,chr2:211403127-211403247,chr2:211404125-211404245,chr2:211404625-211404745,chr2:211405172-211405292,chr2:211405625-211405745,chr2:211406612-211406732,chr2:211407125-211407245,chr2:211407625-211407745,chr2:211408125-211408245,chr2:211408625-211408745,chr2:211409125-211409245,chr2:211409625-211409745,chr2:211410125-211410245,chr2:211410625-211410745,chr2:211411186-211411306,chr2:211411625-211411745,chr2:211412125-211412245,chr2:211413619-211413739,chr2:211414625-211414745,chr2:211415625-211415745,chr2:211416125-211416245,chr2:211416625-211416745,chr2:211417097-211417217,chr2:211417625-211417745,chr2:211418125-211418245,chr2:211418625-211418745,chr2:211419061-211419181,chr2:211419625-211419745,chr2:211420125-211420245,chr2:211420625-211420745,chr2:211421125-211421245,chr2:211421625-211421745,chr2:211422125-211422245,chr2:211422625-211422745,chr2:211423125-211423245,chr2:211423625-211423745,chr2:211424125-211424245,chr2:211424625-211424745,chr2:211425125-211425245,chr2:211425592-211425712,chr2:211426138-211426258,chr2:211426625-211426745,chr2:211427125-211427245,chr2:211427625-211427745,chr2:211428223-211428343,chr2:211429125-211429245,chr2:211429625-211429745,chr2:211430125-211430245,chr2:211430625-211430745,chr2:211431125-211431245,chr2:211431625-211431745,chr2:211432125-211432245,chr2:211432625-211432745,chr2:211433125-211433245,chr2:211433625-211433745,chr2:211434125-211434245,chr2:211434625-211434745,chr2:211435125-211435245,chr2:211436125-211436245,chr2:211436625-211436745,chr2:211437125-211437245,chr2:211437625-211437745,chr2:211438214-211438334,chr2:211439125-211439245,chr2:211440125-211440245,chr2:211440625-211440745,chr2:211441125-211441245,chr2:211441625-211441745,chr2:211442724-211442844,chr2:211444099-211444219,chr2:211444625-211444745,chr2:211445125-211445245,chr2:211445625-211445745,chr2:211446125-211446245,chr2:211446625-211446745,chr2:211447125-211447245,chr2:211447625-211447745,chr2:211448625-211448745,chr2:211449125-211449245,chr2:211449625-211449745,chr2:211450159-211450279,chr2:211450639-211450759,chr2:211451625-211451745,chr2:211452089-211452209,chr2:211452625-211452745,chr2:211453125-211453245,chr2:211453625-211453745,chr2:211454125-211454245,chr2:211454625-211454745,chr2:211455125-211455245,chr2:211455625-211455745,chr2:211456055-211456175,chr2:211457125-211457245,chr2:211457625-211457745,chr2:211458626-211458746,chr2:211459125-211459245,chr2:211460125-211460245,chr2:211460625-211460745,chr2:211461125-211461245,chr2:211461625-211461745,chr2:211462625-211462745,chr2:211463125-211463245,chr2:211463625-211463745,chr2:211464125-211464245,chr2:211464625-211464745,chr2:211465625-211465745,chr2:211466125-211466245,chr2:211466625-211466745,chr2:211467125-211467245,chr2:211467625-211467745,chr2:211468125-211468245,chr2:211468625-211468745,chr2:211469125-211469245,chr2:211469625-211469745,chr2:211470125-211470245,chr2:211470562-211470682,chr2:211471040-211471160,chr2:211471543-211471663,chr2:211472125-211472245,chr2:211472625-211472745,chr2:211473125-211473245,chr2:211474625-211474745,chr2:211475125-211475245,chr2:211475625-211475745,chr2:211476125-211476245,chr2:211476625-211476745,chr2:211477651-211477771,chr2:211478125-211478245,chr2:211478625-211478745,chr2:211479229-211479349,chr2:211480125-211480245,chr2:211480635-211480755,chr2:211481125-211481245,chr2:211481625-211481745,chr2:211482125-211482245,chr2:211483125-211483245,chr2:211484125-211484245,chr2:211484625-211484745,chr2:211485125-211485245,chr2:211486125-211486245,chr2:211487625-211487745,chr2:211488125-211488245,chr2:211488625-211488745,chr2:211489125-211489245,chr2:211489625-211489745,chr2:211490125-211490245,chr2:211490625-211490745,chr2:211491125-211491245,chr2:211491625-211491745,chr2:211492125-211492245,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chr2:212385626-212385746,chr2:212386126-212386246,chr2:212386626-212386746,chr2:212387126-212387246,chr2:212387696-212387816,chr2:212388126-212388246,chr2:212388626-212388746,chr2:212389126-212389246,chr2:212389655-212389775,chr2:212390139-212390259,chr2:212390626-212390746,chr2:212391126-212391246,chr2:212392126-212392246,chr2:212392693-212392813,chr2:212393126-212393246,chr2:212393626-212393746,chr2:212394146-212394266,chr2:212394626-212394746,chr2:212395126-212395246,chr2:212396127-212396247,chr2:212396626-212396746,chr2:212397095-212397215,chr2:212397626-212397746,chr2:212398147-212398267,chr2:212398626-212398746,chr2:212399222-212399342,chr2:212400626-212400746,chr2:212401062-212401182,chr2:212401626-212401746,chr2:212402126-212402246,chr2:212402664-212402784,chr2:212403126-212403246,chr2:212403626-212403746,chr2:212404126-212404246,chr2:212405628-212405748,chr2:212406126-212406246,chr2:212406626-212406746,chr2:212407186-212407306,chr2:212407627-212407747,chr2:212409126-212409246,chr2:212409626-212409746,chr2:212410126-212410246,chr2:212410626-212410746,chr2:212411126-212411246,chr2:212411626-212411746,chr2:212412126-212412246,chr2:212412628-212412748,chr2:212413626-212413746,chr2:212414126-212414246,chr2:212414626-212414746,chr2:212415126-212415246,chr2:212415626-212415746,chr2:212416126-212416246,chr2:212416626-212416746,chr2:212417126-212417246,chr2:212417626-212417746,chr2:212418167-212418287,chr2:212418626-212418746,chr2:212419126-212419246,chr2:212419626-212419746,chr2:212420126-212420246,chr2:212420626-212420746,chr2:212421126-212421246,chr2:212421626-212421746,chr2:212422126-212422246,chr2:212422626-212422746,chr2:212423126-212423246,chr2:212423626-212423746,chr2:212424126-212424246,chr2:212424626-212424746,chr2:212425126-212425246,chr2:212425626-212425746,chr2:212426126-212426246,chr2:212427126-212427246,chr2:212427626-212427746,chr2:212428126-212428246,chr2:212428696-212428816,chr2:212429126-212429246,chr2:212430126-212430246,chr2:212430646-212430766,chr2:212431626-212431746,chr2:212432126-212432246,chr2:212432626-212432746,chr2:212433126-212433246,chr2:212433626-212433746,chr2:212434126-212434246,chr2:212434626-212434746,chr2:212435126-212435246,chr2:212435626-212435746,chr2:212436126-212436246,chr2:212436626-212436746,chr2:212437126-212437246,chr2:212437626-212437746,chr2:212438126-212438246,chr2:212438626-212438746,chr2:212439054-212439174,chr2:212439626-212439746,chr2:212447626-212447746,chr2:212448126-212448246,chr2:212448626-212448746,chr2:212449126-212449246,chr2:212449626-212449746,chr2:212450120-212450240,chr2:212450676-212450796,chr2:212451126-212451246,chr2:212451626-212451746,chr2:212452126-212452246,chr2:212452626-212452746,chr2:212453195-212453315,chr2:212453626-212453746,chr2:212454217-212454337,chr2:212455126-212455246,chr2:212455626-212455746,chr2:212456126-212456246,chr2:212456626-212456746,chr2:212457126-212457246,chr2:212457626-212457746,chr2:212458149-212458269,chr2:212458626-212458746,chr2:212459126-212459246,chr2:212459626-212459746,chr2:212463626-212463746,chr2:212464126-212464246,chr2:212464626-212464746,chr2:212465091-212465211,chr2:212465626-212465746,chr2:212466112-212466232,chr2:212468732-212468852,chr2:212469626-212469746,chr2:212470126-212470246,chr2:212470626-212470746,chr2:212471126-212471246,chr2:212471626-212471746,chr2:212472126-212472246,chr2:212473126-212473246,chr2:212473626-212473746,chr2:212474126-212474246,chr2:212474626-212474746,chr2:212475083-212475203,chr2:212475626-212475746,chr2:212476626-212476746,chr2:212477126-212477246,chr2:212477626-212477746,chr2:212478126-212478246,chr2:212478626-212478746,chr2:212479164-212479284,chr2:212479626-212479746,chr2:212480126-212480246,chr2:212480626-212480746,chr2:212481636-212481756,chr2:212482126-212482246,chr2:212483126-212483246,chr2:212483626-212483746,chr2:212484126-212484246,chr2:212484626-212484746,chr2:212485126-212485246,chr2:212485549-212485669,chr2:212486126-212486246,chr2:212486626-212486746,chr2:212487212-212487332,chr2:212488126-212488246,chr2:212488626-212488746,chr2:212489126-212489246,chr2:212489626-212489746,chr2:212490626-212490746,chr2:212491126-212491246,chr2:212491626-212491746,chr2:212492126-212492246,chr2:212492626-212492746,chr2:212493126-212493246,chr2:212493626-212493746,chr2:212494126-212494246,chr2:212495126-212495246,chr2:212495626-212495746,chr2:212496126-212496246,chr2:212496626-212496746,chr2:212497177-212497297,chr2:212497626-212497746,chr2:212498127-212498247,chr2:212498626-212498746,chr2:212499126-212499246,chr2:212499626-212499746,chr2:212500126-212500246,chr2:212500626-212500746,chr2:212501126-212501246,chr2:212501626-212501746,chr2:212502126-212502246,chr2:212502665-212502785,chr2:212503237-212503357,chr2:212504126-212504246,chr2:212504627-212504747,chr2:212505626-212505746,chr2:212508126-212508246,chr2:212508626-212508746,chr2:212509126-212509246,chr2:212509626-212509746,chr2:212510213-212510333,chr2:212511126-212511246,chr2:212511626-212511746,chr2:212512126-212512246,chr2:212512626-212512746,chr2:212513053-212513173,chr2:212514126-212514246,chr2:212515126-212515246,chr2:212515626-212515746,chr2:212516126-212516246,chr2:212516626-212516746,chr2:212517126-212517246,chr2:212517626-212517746,chr2:212518126-212518246,chr2:212518626-212518746,chr2:212519126-212519246,chr2:212520126-212520246,chr2:212520626-212520746,chr2:212521126-212521246,chr2:212522022-212522142,chr2:212522626-212522746,chr2:212523126-212523246,chr2:212523626-212523746,chr2:212524126-212524246,chr2:212524626-212524746,chr2:212525126-212525246,chr2:212525682-212525802,chr2:212526126-212526246,chr2:212526626-212526746,chr2:212527126-212527246,chr2:212527593-212527713,chr2:212528126-212528246,chr2:212528626-212528746,chr2:212529126-212529246,chr2:212529626-212529746,chr2:212530126-212530246,chr2:212530626-212530746,chr2:212531126-212531246,chr2:212531626-212531746,chr2:212532126-212532246,chr2:212532626-212532746,chr2:212533126-212533246,chr2:212533626-212533746,chr2:212534126-212534246,chr2:212534626-212534746,chr2:212535126-212535246,chr2:212535626-212535746,chr2:212536085-212536205,chr2:212536626-212536746,chr2:212537126-212537246,chr2:212537626-212537746,chr2:212538126-212538246,chr2:212539126-212539246；
ESR1：
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ESR2：
chr14:64084565-64084685,chr14:64086080-64086200,chr14:64086605-64086725,chr14:64087092-64087212,chr14:64087580-64087700,chr14:64088160-64088280,chr14:64088684-64088804,chr14:64089580-64089700,chr14:64090042-64090162,chr14:64090581-64090701,chr14:64091080-64091200,chr14:64091580-64091700,chr14:64092080-64092200,chr14:64092580-64092700,chr14:64093080-64093200,chr14:64093580-64093700,chr14:64094603-64094723,chr14:64095117-64095237,chr14:64096580-64096700,chr14:64097080-64097200,chr14:64097527-64097647,chr14:64098080-64098200,chr14:64098580-64098700,chr14:64099080-64099200,chr14:64099580-64099700,chr14:64101586-64101706,chr14:64102038-64102158,chr14:64103109-64103229,chr14:64103580-64103700,chr14:64104080-64104200,chr14:64105080-64105200,chr14:64105692-64105812,chr14:64106637-64106757,chr14:64107134-64107254,chr14:64107580-64107700,chr14:64108580-64108700,chr14:64109104-64109224,chr14:64109581-64109701,chr14:64110080-64110200,chr14:64110580-64110700,chr14:64112080-64112200,chr14:64112580-64112700,chr14:64113080-64113200,chr14:64113580-64113700,chr14:64114080-64114200,chr14:64114525-64114645,chr14:64115080-64115200,chr14:64116196-64116316,chr14:64116695-64116815,chr14:64118080-64118200,chr14:64119131-64119251,chr14:64119580-64119700,chr14:64120080-64120200,chr14:64121011-64121131,chr14:64121580-64121700,chr14:64122080-64122200,chr14:64123191-64123311,chr14:64124580-64124700,chr14:64125080-64125200,chr14:64125580-64125700,chr14:64126067-64126187,chr14:64126580-64126700,chr14:64128080-64128200,chr14:64128580-64128700,chr14:64129580-64129700,chr14:64130080-64130200,chr14:64131080-64131200,chr14:64132090-64132210,chr14:64132580-64132700,chr14:64133580-64133700,chr14:64134080-64134200,chr14:64134580-64134700,chr14:64135080-64135200,chr14:64135580-64135700,chr14:64136580-64136700,chr14:64137071-64137191,chr14:64137580-64137700,chr14:64138080-64138200,chr14:64138580-64138700,chr14:64139692-64139812,chr14:64140580-64140700,chr14:64141080-64141200,chr14:64141580-64141700,chr14:64142080-64142200,chr14:64142580-64142700,chr14:64143080-64143200,chr14:64143580-64143700,chr14:64144080-64144200,chr14:64144580-64144700,chr14:64145588-64145708,chr14:64146080-64146200,chr14:64146580-64146700,chr14:64147080-64147200,chr14:64147580-64147700,chr14:64148580-64148700,chr14:64149580-64149700,chr14:64150580-64150700,chr14:64151080-64151200,chr14:64151580-64151700,chr14:64152080-64152200,chr14:64152580-64152700,chr14:64153080-64153200,chr14:64153504-64153624,chr14:64155080-64155200,chr14:64155531-64155651,chr14:64156080-64156200,chr14:64156993-64157113,chr14:64158065-64158185,chr14:64158580-64158700,chr14:64159080-64159200,chr14:64159580-64159700,chr14:64160144-64160264,chr14:64160580-64160700,chr14:64161502-64161622,chr14:64162080-64162200,chr14:64162580-64162700,chr14:64163080-64163200,chr14:64163580-64163700,chr14:64164580-64164700,chr14:64165166-64165286,chr14:64166050-64166170,chr14:64166566-64166686,chr14:64167151-64167271,chr14:64167580-64167700,chr14:64168024-64168144,chr14:64168656-64168776,chr14:64169080-64169200,chr14:64169580-64169700,chr14:64170080-64170200,chr14:64170580-64170700,chr14:64171093-64171213,chr14:64171580-64171700,chr14:64172195-64172315,chr14:64173508-64173628,chr14:64173980-64174100,chr14:64174580-64174700,chr14:64175080-64175200,chr14:64175580-64175700,chr14:64176080-64176200,chr14:64176580-64176700,chr14:64177080-64177200,chr14:64177580-64177700,chr14:64178080-64178200,chr14:64179028-64179148,chr14:64179628-64179748,chr14:64180080-64180200,chr14:64181080-64181200,chr14:64181580-64181700,chr14:64182080-64182200,chr14:64184033-64184153,chr14:64184580-64184700,chr14:64186080-64186200,chr14:64186580-64186700,chr14:64187080-64187200,chr14:64187580-64187700,chr14:64188080-64188200,chr14:64188580-64188700,chr14:64189580-64189700,chr14:64190080-64190200,chr14:64190580-64190700,chr14:64191080-64191200,chr14:64191580-64191700,chr14:64192080-64192200,chr14:64193080-64193200,chr14:64193580-64193700,chr14:64194080-64194200,chr14:64194585-64194705,chr14:64195080-64195200,chr14:64195580-64195700,chr14:64196080-64196200,chr14:64196580-64196700,chr14:64197080-64197200,chr14:64197580-64197700,chr14:64198080-64198200,chr14:64198580-64198700,chr14:64199080-64199200,chr14:64200080-64200200,chr14:64200580-64200700,chr14:64201580-64201700,chr14:64202080-64202200,chr14:64202580-64202700,chr14:64203080-64203200,chr14:64203580-64203700,chr14:64204080-64204200,chr14:64204580-64204700,chr14:64205580-64205700,chr14:64206080-64206200,chr14:64206580-64206700,chr14:64207080-64207200,chr14:64207580-64207700,chr14:64208080-64208200,chr14:64208580-64208700,chr14:64209080-64209200,chr14:64209580-64209700,chr14:64210080-64210200,chr14:64210580-64210700,chr14:64211580-64211700,chr14:64212080-64212200,chr14:64212580-64212700,chr14:64213080-64213200,chr14:64213580-64213700,chr14:64214092-64214212,chr14:64214580-64214700,chr14:64215080-64215200,chr14:64215580-64215700,chr14:64216080-64216200,chr14:64216580-64216700,chr14:64217080-64217200,chr14:64217580-64217700,chr14:64218080-64218200,chr14:64218580-64218700,chr14:64219080-64219200,chr14:64219580-64219700,chr14:64220080-64220200,chr14:64220580-64220700,chr14:64221152-64221272,chr14:64221580-64221700,chr14:64222080-64222200,chr14:64223080-64223200,chr14:64223529-64223649,chr14:64223964-64224084,chr14:64224580-64224700,chr14:64225080-64225200,chr14:64225580-64225700,chr14:64226080-64226200,chr14:64226580-64226700,chr14:64227080-64227200,chr14:64227580-64227700,chr14:64228042-64228162,chr14:64228580-64228700,chr14:64229080-64229200,chr14:64229553-64229673,chr14:64230194-64230314,chr14:64231163-64231283,chr14:64232080-64232200,chr14:64232580-64232700,chr14:64233080-64233200,chr14:64234134-64234254,chr14:64234580-64234700,chr14:64235080-64235200,chr14:64235580-64235700,chr14:64236080-64236200,chr14:64236580-64236700,chr14:64237494-64237614,chr14:64238081-64238201,chr14:64238593-64238713,chr14:64239080-64239200,chr14:64239580-64239700,chr14:64240080-64240200,chr14:64241580-64241700,chr14:64242580-64242700,chr14:64243627-64243747,chr14:64244580-64244700,chr14:64245080-64245200,chr14:64245580-64245700,chr14:64247001-64247121,chr14:64247580-64247700,chr14:64248580-64248700,chr14:64249080-64249200,chr14:64249580-64249700,chr14:64250080-64250200,chr14:64250580-64250700,chr14:64251080-64251200,chr14:64251580-64251700,chr14:64253599-64253719,chr14:64254080-64254200,chr14:64255080-64255200,chr14:64256080-64256200,chr14:64257080-64257200,chr14:64257580-64257700,chr14:64258596-64258716,chr14:64259080-64259200,chr14:64259580-64259700,chr14:64260080-64260200,chr14:64260580-64260700,chr14:64261080-64261200,chr14:64262012-64262132,chr14:64262487-64262607,chr14:64263080-64263200,chr14:64263687-64263807,chr14:64265080-64265200,chr14:64265580-64265700,chr14:64266080-64266200,chr14:64267143-64267263,chr14:64268080-64268200,chr14:64269080-64269200,chr14:64269580-64269700,chr14:64270055-64270175,chr14:64271012-64271132,chr14:64276080-64276200,chr14:64276580-64276700,chr14:64277080-64277200,chr14:64277629-64277749,chr14:64278080-64278200,chr14:64278580-64278700,chr14:64279580-64279700,chr14:64280080-64280200,chr14:64280580-64280700,chr14:64281126-64281246,chr14:64281580-64281700,chr14:64282580-64282700,chr14:64283080-64283200,chr14:64284601-64284721,chr14:64285128-64285248,chr14:64286080-64286200,chr14:64286580-64286700,chr14:64287580-64287700,chr14:64288080-64288200,chr14:64288608-64288728,chr14:64289088-64289208,chr14:64289581-64289701,chr14:64290682-64290802,chr14:64291580-64291700,chr14:64292080-64292200,chr14:64292580-64292700,chr14:64293080-64293200,chr14:64293580-64293700,chr14:64294080-64294200,chr14:64294671-64294791,chr14:64295580-64295700,chr14:64296081-64296201,chr14:64296580-64296700,chr14:64297030-64297150,chr14:64297639-64297759,chr14:64298072-64298192,chr14:64298580-64298700,chr14:64299080-64299200,chr14:64299641-64299761,chr14:64301539-64301659,chr14:64302050-64302170,chr14:64302613-64302733,chr14:64303080-64303200,chr14:64303580-64303700,chr14:64305675-64305795,chr14:64306580-64306700,chr14:64308555-64308675,chr14:64309110-64309230,chr14:64309598-64309718,chr14:64311080-64311200,chr14:64312080-64312200,chr14:64313528-64313648,chr14:64319048-64319168,chr14:64321088-64321208,chr14:64321580-64321700,chr14:64322554-64322674,chr14:64323080-64323200,chr14:64323580-64323700,chr14:64324580-64324700,chr14:64325123-64325243,chr14:64326080-64326200,chr14:64326580-64326700,chr14:64327080-64327200,chr14:64327616-64327736,chr14:64328480-64328600,chr14:64329054-64329174,chr14:64329688-64329808,chr14:64331080-64331200,chr14:64332080-64332200,chr14:64333093-64333213,chr14:64334080-64334200,chr14:64335172-64335292,chr14:64335671-64335791,chr14:64336580-64336700,chr14:64337661-64337781,chr14:64338580-64338700；
FANCC：
chr9:95098855-95098975,chr9:95099364-95099484,chr9:95099898-95100018,chr9:95100364-95100484,chr9:95100909-95101029,chr9:95101364-95101484,chr9:95101864-95101984,chr9:95102364-95102484,chr9:95102864-95102984,chr9:95103354-95103474,chr9:95103864-95103984,chr9:95104364-95104484,chr9:95105864-95105984,chr9:95106904-95107024,chr9:95107364-95107484,chr9:95107864-95107984,chr9:95108364-95108484,chr9:95109430-95109550,chr9:95109864-95109984,chr9:95110364-95110484,chr9:95110864-95110984,chr9:95111364-95111484,chr9:95111864-95111984,chr9:95112364-95112484,chr9:95112864-95112984,chr9:95113364-95113484,chr9:95114364-95114484,chr9:95114859-95114979,chr9:95115364-95115484,chr9:95115864-95115984,chr9:95116364-95116484,chr9:95116864-95116984,chr9:95117364-95117484,chr9:95118331-95118451,chr9:95118864-95118984,chr9:95120329-95120449,chr9:95120809-95120929,chr9:95121287-95121407,chr9:95121767-95121887,chr9:95122364-95122484,chr9:95122864-95122984,chr9:95124364-95124484,chr9:95124864-95124984,chr9:95125364-95125484,chr9:95125864-95125984,chr9:95126364-95126484,chr9:95126864-95126984,chr9:95127864-95127984,chr9:95128364-95128484,chr9:95128812-95128932,chr9:95129364-95129484,chr9:95129864-95129984,chr9:95130365-95130485,chr9:95130864-95130984,chr9:95131364-95131484,chr9:95131864-95131984,chr9:95132364-95132484,chr9:95132864-95132984,chr9:95133364-95133484,chr9:95133864-95133984,chr9:95134364-95134484,chr9:95134864-95134984,chr9:95135364-95135484,chr9:95135800-95135920,chr9:95136374-95136494,chr9:95136864-95136984,chr9:95137364-95137484,chr9:95137864-95137984,chr9:95138364-95138484,chr9:95138864-95138984,chr9:95139364-95139484,chr9:95139864-95139984,chr9:95140364-95140484,chr9:95140864-95140984,chr9:95141364-95141484,chr9:95141864-95141984,chr9:95143364-95143484,chr9:95143864-95143984,chr9:95144364-95144484,chr9:95144864-95144984,chr9:95145364-95145484,chr9:95146753-95146873,chr9:95147864-95147984,chr9:95148364-95148484,chr9:95148864-95148984,chr9:95149864-95149984,chr9:95151351-95151471,chr9:95151917-95152037,chr9:95153864-95153984,chr9:95154318-95154438,chr9:95154827-95154947,chr9:95155365-95155485,chr9:95156364-95156484,chr9:95156864-95156984,chr9:95157364-95157484,chr9:95157864-95157984,chr9:95158364-95158484,chr9:95158864-95158984,chr9:95160945-95161065,chr9:95162864-95162984,chr9:95163364-95163484,chr9:95164364-95164484,chr9:95165864-95165984,chr9:95166364-95166484,chr9:95166809-95166929,chr9:95168265-95168385,chr9:95169864-95169984,chr9:95170364-95170484,chr9:95170864-95170984,chr9:95171364-95171484,chr9:95171864-95171984,chr9:95172364-95172484,chr9:95172864-95172984,chr9:95173364-95173484,chr9:95173890-95174010,chr9:95174423-95174543,chr9:95174864-95174984,chr9:95175364-95175484,chr9:95175864-95175984,chr9:95176364-95176484,chr9:95176864-95176984,chr9:95177864-95177984,chr9:95178364-95178484,chr9:95178864-95178984,chr9:95180339-95180459,chr9:95181364-95181484,chr9:95181864-95181984,chr9:95182876-95182996,chr9:95183364-95183484,chr9:95183864-95183984,chr9:95184364-95184484,chr9:95184864-95184984,chr9:95185364-95185484,chr9:95185864-95185984,chr9:95186431-95186551,chr9:95187364-95187484,chr9:95187864-95187984,chr9:95188364-95188484,chr9:95188864-95188984,chr9:95189364-95189484,chr9:95189864-95189984,chr9:95190872-95190992,chr9:95191957-95192077,chr9:95192864-95192984,chr9:95193415-95193535,chr9:95193864-95193984,chr9:95194362-95194482,chr9:95195864-95195984,chr9:95196402-95196522,chr9:95196865-95196985,chr9:95197864-95197984,chr9:95199364-95199484,chr9:95199864-95199984,chr9:95200413-95200533,chr9:95200864-95200984,chr9:95201364-95201484,chr9:95201864-95201984,chr9:95202364-95202484,chr9:95202864-95202984,chr9:95203376-95203496,chr9:95203902-95204022,chr9:95204364-95204484,chr9:95204864-95204984,chr9:95205364-95205484,chr9:95205864-95205984,chr9:95206364-95206484,chr9:95206864-95206984,chr9:95207364-95207484,chr9:95207864-95207984,chr9:95209364-95209484,chr9:95209868-95209988,chr9:95210364-95210484,chr9:95210864-95210984,chr9:95211401-95211521,chr9:95211876-95211996,chr9:95212364-95212484,chr9:95212836-95212956,chr9:95215326-95215446,chr9:95215888-95216008,chr9:95216368-95216488,chr9:95216848-95216968,chr9:95217864-95217984,chr9:95218970-95219090,chr9:95220853-95220973,chr9:95221864-95221984,chr9:95222364-95222484,chr9:95222864-95222984,chr9:95223364-95223484,chr9:95224864-95224984,chr9:95225364-95225484,chr9:95225864-95225984,chr9:95226364-95226484,chr9:95227364-95227484,chr9:95227864-95227984,chr9:95228818-95228938,chr9:95229418-95229538,chr9:95229864-95229984,chr9:95230340-95230460,chr9:95231818-95231938,chr9:95232364-95232484,chr9:95232864-95232984,chr9:95233364-95233484,chr9:95233864-95233984,chr9:95234301-95234421,chr9:95234864-95234984,chr9:95235867-95235987,chr9:95236364-95236484,chr9:95236864-95236984,chr9:95237364-95237484,chr9:95238364-95238484,chr9:95238853-95238973,chr9:95239364-95239484,chr9:95239864-95239984,chr9:95240364-95240484,chr9:95240950-95241070,chr9:95241939-95242059,chr9:95242364-95242484,chr9:95242864-95242984,chr9:95243364-95243484,chr9:95243864-95243984,chr9:95244301-95244421,chr9:95244827-95244947,chr9:95245250-95245370,chr9:95245946-95246066,chr9:95246864-95246984,chr9:95247364-95247484,chr9:95247864-95247984,chr9:95248364-95248484,chr9:95248864-95248984,chr9:95249364-95249484,chr9:95249864-95249984,chr9:95250364-95250484,chr9:95250864-95250984,chr9:95252364-95252484,chr9:95253356-95253476,chr9:95260864-95260984,chr9:95261364-95261484,chr9:95261864-95261984,chr9:95262312-95262432,chr9:95262864-95262984,chr9:95263864-95263984,chr9:95264364-95264484,chr9:95264864-95264984,chr9:95265364-95265484,chr9:95265864-95265984,chr9:95266364-95266484,chr9:95266864-95266984,chr9:95267864-95267984,chr9:95268367-95268487,chr9:95268864-95268984,chr9:95269364-95269484,chr9:95270364-95270484,chr9:95270864-95270984,chr9:95271364-95271484,chr9:95271830-95271950,chr9:95272355-95272475,chr9:95272842-95272962,chr9:95273364-95273484,chr9:95273864-95273984,chr9:95274864-95274984,chr9:95275865-95275985,chr9:95276364-95276484,chr9:95277458-95277578,chr9:95280364-95280484,chr9:95280864-95280984,chr9:95281364-95281484,chr9:95282364-95282484,chr9:95282956-95283076,chr9:95284364-95284484,chr9:95284930-95285050,chr9:95285364-95285484,chr9:95285864-95285984,chr9:95286364-95286484,chr9:95286864-95286984,chr9:95287364-95287484,chr9:95287864-95287984,chr9:95288364-95288484,chr9:95289417-95289537,chr9:95289938-95290058,chr9:95290484-95290604,chr9:95292391-95292511,chr9:95292864-95292984,chr9:95293364-95293484,chr9:95293864-95293984,chr9:95294364-95294484,chr9:95294864-95294984,chr9:95295864-95295984,chr9:95296364-95296484,chr9:95296864-95296984,chr9:95297364-95297484,chr9:95297835-95297955,chr9:95298364-95298484,chr9:95298864-95298984,chr9:95299364-95299484,chr9:95299864-95299984,chr9:95300355-95300475,chr9:95300864-95300984,chr9:95301317-95301437,chr9:95302422-95302542,chr9:95303364-95303484,chr9:95303827-95303947,chr9:95304307-95304427,chr9:95304864-95304984,chr9:95305364-95305484,chr9:95305864-95305984,chr9:95306364-95306484,chr9:95307364-95307484,chr9:95309364-95309484,chr9:95309839-95309959,chr9:95310364-95310484,chr9:95310864-95310984,chr9:95311364-95311484,chr9:95311864-95311984,chr9:95312864-95312984,chr9:95313364-95313484,chr9:95313864-95313984,chr9:95314864-95314984,chr9:95315864-95315984,chr9:95316364-95316484,chr9:95316864-95316984,chr9:95317364-95317484,chr9:95317864-95317984,chr9:95318917-95319037,chr9:95319864-95319984,chr9:95320411-95320531,chr9:95320914-95321034,chr9:95321364-95321484,chr9:95321864-95321984,chr9:95322364-95322484,chr9:95322976-95323096,chr9:95330364-95330484,chr9:95333364-95333484,chr9:95333864-95333984,chr9:95334357-95334477,chr9:95335364-95335484,chr9:95335864-95335984,chr9:95336364-95336484,chr9:95336861-95336981,chr9:95338859-95338979,chr9:95339328-95339448,chr9:95341364-95341484,chr9:95342364-95342484,chr9:95343454-95343574,chr9:95346336-95346456,chr9:95346864-95346984,chr9:95347896-95348016,chr9:95348985-95349105,chr9:95349867-95349987,chr9:95350364-95350484,chr9:95350885-95351005,chr9:95351364-95351484,chr9:95352365-95352485,chr9:95352864-95352984,chr9:95353364-95353484,chr9:95354809-95354929,chr9:95355364-95355484,chr9:95355864-95355984,chr9:95356364-95356484,chr9:95356846-95356966,chr9:95357440-95357560,chr9:95357864-95357984,chr9:95358365-95358485,chr9:95360342-95360462,chr9:95360864-95360984,chr9:95361813-95361933,chr9:95362364-95362484,chr9:95362864-95362984,chr9:95363364-95363484,chr9:95363864-95363984,chr9:95364364-95364484,chr9:95364864-95364984,chr9:95365364-95365484,chr9:95365864-95365984,chr9:95366309-95366429,chr9:95366864-95366984,chr9:95367864-95367984,chr9:95368362-95368482,chr9:95368864-95368984,chr9:95369864-95369984,chr9:95370364-95370484,chr9:95370791-95370911,chr9:95371864-95371984,chr9:95372310-95372430,chr9:95372864-95372984,chr9:95373364-95373484,chr9:95373864-95373984,chr9:95374364-95374484,chr9:95374864-95374984,chr9:95375432-95375552,chr9:95376841-95376961,chr9:95377346-95377466,chr9:95377864-95377984,chr9:95378364-95378484,chr9:95379864-95379984,chr9:95381365-95381485,chr9:95381915-95382035,chr9:95382440-95382560,chr9:95383364-95383484,chr9:95383864-95383984,chr9:95384364-95384484,chr9:95385368-95385488,chr9:95385864-95385984,chr9:95386364-95386484,chr9:95387472-95387592,chr9:95388326-95388446,chr9:95388864-95388984,chr9:95389909-95390029,chr9:95390364-95390484,chr9:95390864-95390984,chr9:95391364-95391484,chr9:95391883-95392003,chr9:95392864-95392984,chr9:95393364-95393484,chr9:95393821-95393941,chr9:95394364-95394484,chr9:95394864-95394984,chr9:95398364-95398484,chr9:95398864-95398984,chr9:95405364-95405484,chr9:95405831-95405951,chr9:95406364-95406484,chr9:95406864-95406984,chr9:95407364-95407484,chr9:95408475-95408595,chr9:95409353-95409473,chr9:95409935-95410055,chr9:95410364-95410484,chr9:95410864-95410984,chr9:95411364-95411484,chr9:95411864-95411984,chr9:95412398-95412518,chr9:95413364-95413484,chr9:95413824-95413944,chr9:95414274-95414394,chr9:95414958-95415078,chr9:95416332-95416452,chr9:95416812-95416932,chr9:95417364-95417484,chr9:95418364-95418484,chr9:95418876-95418996,chr9:95419364-95419484,chr9:95419826-95419946,chr9:95420364-95420484,chr9:95420864-95420984,chr9:95421467-95421587,chr9:95422864-95422984,chr9:95423364-95423484,chr9:95423954-95424074,chr9:95424434-95424554,chr9:95425274-95425394,chr9:95425980-95426100,chr9:95426864-95426984；
MRE11：
chr11:94415321-94415441,chr11:94416321-94416441,chr11:94416845-94416965,chr11:94417321-94417441,chr11:94417821-94417941,chr11:94418321-94418441,chr11:94418821-94418941,chr11:94419321-94419441,chr11:94419821-94419941,chr11:94420321-94420441,chr11:94421321-94421441,chr11:94421821-94421941,chr11:94422321-94422441,chr11:94423321-94423441,chr11:94423821-94423941,chr11:94429881-94430001,chr11:94430321-94430441,chr11:94430751-94430871,chr11:94431322-94431442,chr11:94431821-94431941,chr11:94432316-94432436,chr11:94432880-94433000,chr11:94433360-94433480,chr11:94433821-94433941,chr11:94434424-94434544,chr11:94434930-94435050,chr11:94435821-94435941,chr11:94436821-94436941,chr11:94437321-94437441,chr11:94437745-94437865,chr11:94438321-94438441,chr11:94438821-94438941,chr11:94439321-94439441,chr11:94440321-94440441,chr11:94440821-94440941,chr11:94441311-94441431,chr11:94442361-94442481,chr11:94442822-94442942,chr11:94443421-94443541,chr11:94443842-94443962,chr11:94444821-94444941,chr11:94445821-94445941,chr11:94446420-94446540,chr11:94447321-94447441,chr11:94447839-94447959,chr11:94448822-94448942,chr11:94449274-94449394,chr11:94450431-94450551,chr11:94451246-94451366,chr11:94451788-94451908,chr11:94452321-94452441,chr11:94453321-94453441,chr11:94453784-94453904,chr11:94454351-94454471,chr11:94454821-94454941,chr11:94455321-94455441,chr11:94455796-94455916,chr11:94456321-94456441,chr11:94456821-94456941,chr11:94457321-94457441,chr11:94458321-94458441,chr11:94458890-94459010,chr11:94459334-94459454,chr11:94460322-94460442,chr11:94460821-94460941,chr11:94463922-94464042,chr11:94464821-94464941,chr11:94465298-94465418,chr11:94466379-94466499,chr11:94466822-94466942,chr11:94467321-94467441,chr11:94467821-94467941,chr11:94468321-94468441,chr11:94469410-94469530,chr11:94470321-94470441,chr11:94470821-94470941,chr11:94471321-94471441,chr11:94471821-94471941,chr11:94472321-94472441,chr11:94472899-94473019,chr11:94473338-94473458,chr11:94473821-94473941,chr11:94474321-94474441,chr11:94474821-94474941,chr11:94475420-94475540,chr11:94476321-94476441,chr11:94477321-94477441,chr11:94478321-94478441,chr11:94478821-94478941,chr11:94479258-94479378,chr11:94479821-94479941,chr11:94480321-94480441,chr11:94480777-94480897,chr11:94481361-94481481,chr11:94481788-94481908,chr11:94482225-94482345,chr11:94482941-94483061,chr11:94484321-94484441,chr11:94484753-94484873,chr11:94485353-94485473,chr11:94485821-94485941,chr11:94486321-94486441,chr11:94486821-94486941,chr11:94487245-94487365,chr11:94487860-94487980,chr11:94488927-94489047,chr11:94489821-94489941,chr11:94490321-94490441,chr11:94490821-94490941,chr11:94491321-94491441,chr11:94491821-94491941,chr11:94492335-94492455,chr11:94492821-94492941,chr11:94493321-94493441,chr11:94493821-94493941,chr11:94494321-94494441,chr11:94494821-94494941,chr11:94495321-94495441,chr11:94495939-94496059,chr11:94496821-94496941,chr11:94497351-94497471,chr11:94497821-94497941,chr11:94498321-94498441,chr11:94498821-94498941,chr11:94499321-94499441,chr11:94499821-94499941,chr11:94500276-94500396,chr11:94500821-94500941,chr11:94501342-94501462,chr11:94501905-94502025,chr11:94502939-94503059,chr11:94503787-94503907,chr11:94504321-94504441,chr11:94504821-94504941,chr11:94506322-94506442,chr11:94506864-94506984,chr11:94507321-94507441,chr11:94507843-94507963,chr11:94508321-94508441,chr11:94509283-94509403,chr11:94509763-94509883,chr11:94510339-94510459,chr11:94510796-94510916,chr11:94511821-94511941,chr11:94512321-94512441；
NBS1：
chr8:89933302-89933422,chr8:89934221-89934341,chr8:89934721-89934841,chr8:89935335-89935455,chr8:89936330-89936450,chr8:89937221-89937341,chr8:89937709-89937829,chr8:89938721-89938841,chr8:89939223-89939343,chr8:89939721-89939841,chr8:89940221-89940341,chr8:89940721-89940841,chr8:89941220-89941340,chr8:89941721-89941841,chr8:89942221-89942341,chr8:89942721-89942841,chr8:89943221-89943341,chr8:89943721-89943841,chr8:89944859-89944979,chr8:89945721-89945841,chr8:89946221-89946341,chr8:89946721-89946841,chr8:89947721-89947841,chr8:89948221-89948341,chr8:89948721-89948841,chr8:89949326-89949446,chr8:89950721-89950841,chr8:89951311-89951431,chr8:89952183-89952303,chr8:89952720-89952840,chr8:89953221-89953341,chr8:89953721-89953841,chr8:89954221-89954341,chr8:89954721-89954841,chr8:89955221-89955341,chr8:89955721-89955841,chr8:89956221-89956341,chr8:89957764-89957884,chr8:89958244-89958364,chr8:89958721-89958841,chr8:89959221-89959341,chr8:89960221-89960341,chr8:89960817-89960937,chr8:89961721-89961841,chr8:89962221-89962341,chr8:89962721-89962841,chr8:89963221-89963341,chr8:89964255-89964375,chr8:89965224-89965344,chr8:89965769-89965889,chr8:89966221-89966341,chr8:89967323-89967443,chr8:89968233-89968353,chr8:89968656-89968776,chr8:89969221-89969341,chr8:89970241-89970361,chr8:89970721-89970841,chr8:89971221-89971341,chr8:89971721-89971841,chr8:89972221-89972341,chr8:89972721-89972841,chr8:89973222-89973342,chr8:89973707-89973827,chr8:89974221-89974341,chr8:89974650-89974770,chr8:89975221-89975341,chr8:89975721-89975841,chr8:89976733-89976853,chr8:89977808-89977928,chr8:89978721-89978841,chr8:89979258-89979378,chr8:89979704-89979824,chr8:89980221-89980341,chr8:89980721-89980841,chr8:89981221-89981341,chr8:89981721-89981841,chr8:89982221-89982341,chr8:89982721-89982841,chr8:89983207-89983327,chr8:89983721-89983841,chr8:89984221-89984341,chr8:89984721-89984841,chr8:89985221-89985341,chr8:89985710-89985830,chr8:89986221-89986341,chr8:89986759-89986879,chr8:89987221-89987341,chr8:89987721-89987841,chr8:89988221-89988341,chr8:89988721-89988841,chr8:89989222-89989342,chr8:89989721-89989841,chr8:89990221-89990341,chr8:89990721-89990841,chr8:89991721-89991841,chr8:89992221-89992341,chr8:89992767-89992887,chr8:89993221-89993341,chr8:89993745-89993865,chr8:89995721-89995841,chr8:89996221-89996341,chr8:89996721-89996841,chr8:89997221-89997341,chr8:89997721-89997841,chr8:89999221-89999341,chr8:90000221-90000341,chr8:90000721-90000841,chr8:90001221-90001341,chr8:90001721-90001841,chr8:90002178-90002298,chr8:90002721-90002841,chr8:90003221-90003341；
NF1：
chr17:31007684-31007804,chr17:31008184-31008304,chr17:31008724-31008844,chr17:31009184-31009304,chr17:31009684-31009804,chr17:31010184-31010304,chr17:31010684-31010804,chr17:31011184-31011304,chr17:31012184-31012304,chr17:31014684-31014804,chr17:31015184-31015304,chr17:31016280-31016400,chr17:31017184-31017304,chr17:31018684-31018804,chr17:31019705-31019825,chr17:31020184-31020304,chr17:31020719-31020839,chr17:31021154-31021274,chr17:31021684-31021804,chr17:31022190-31022310,chr17:31022684-31022804,chr17:31023170-31023290,chr17:31023699-31023819,chr17:31024185-31024305,chr17:31024684-31024804,chr17:31026184-31026304,chr17:31026684-31026804,chr17:31027691-31027811,chr17:31028184-31028304,chr17:31028611-31028731,chr17:31029184-31029304,chr17:31029684-31029804,chr17:31031122-31031242,chr17:31031765-31031885,chr17:31032684-31032804,chr17:31033184-31033304,chr17:31033703-31033823,chr17:31034184-31034304,chr17:31034684-31034804,chr17:31037184-31037304,chr17:31039684-31039804,chr17:31040207-31040327,chr17:31041184-31041304,chr17:31041617-31041737,chr17:31042185-31042305,chr17:31042685-31042805,chr17:31043751-31043871,chr17:31044184-31044304,chr17:31045684-31045804,chr17:31046184-31046304,chr17:31048184-31048304,chr17:31048684-31048804,chr17:31049184-31049304,chr17:31049684-31049804,chr17:31050684-31050804,chr17:31051684-31051804,chr17:31052156-31052276,chr17:31052684-31052804,chr17:31053238-31053358,chr17:31054152-31054272,chr17:31055112-31055232,chr17:31055722-31055842,chr17:31056184-31056304,chr17:31058263-31058383,chr17:31059211-31059331,chr17:31059685-31059805,chr17:31061184-31061304,chr17:31061684-31061804,chr17:31062184-31062304,chr17:31063265-31063385,chr17:31063742-31063862,chr17:31064184-31064304,chr17:31065122-31065242,chr17:31065684-31065804,chr17:31066184-31066304,chr17:31066684-31066804,chr17:31067684-31067804,chr17:31068184-31068304,chr17:31068684-31068804,chr17:31069244-31069364,chr17:31069784-31069904,chr17:31070672-31070792,chr17:31072184-31072304,chr17:31072685-31072805,chr17:31073290-31073410,chr17:31074184-31074304,chr17:31075184-31075304,chr17:31075684-31075804,chr17:31076155-31076275,chr17:31076752-31076872,chr17:31077684-31077804,chr17:31078184-31078304,chr17:31078684-31078804,chr17:31079684-31079804,chr17:31082738-31082858,chr17:31083184-31083304,chr17:31084154-31084274,chr17:31085684-31085804,chr17:31086184-31086304,chr17:31087184-31087304,chr17:31087736-31087856,chr17:31088233-31088353,chr17:31088684-31088804,chr17:31089193-31089313,chr17:31089684-31089804,chr17:31090671-31090791,chr17:31091184-31091304,chr17:31092269-31092389,chr17:31092960-31093080,chr17:31094184-31094304,chr17:31094684-31094804,chr17:31095184-31095304,chr17:31095684-31095804,chr17:31096184-31096304,chr17:31096684-31096804,chr17:31097604-31097724,chr17:31098184-31098304,chr17:31099184-31099304,chr17:31100184-31100304,chr17:31100684-31100804,chr17:31101184-31101304,chr17:31101684-31101804,chr17:31102184-31102304,chr17:31102729-31102849,chr17:31103159-31103279,chr17:31104184-31104304,chr17:31104684-31104804,chr17:31105185-31105305,chr17:31105792-31105912,chr17:31106684-31106804,chr17:31107184-31107304,chr17:31107736-31107856,chr17:31108679-31108799,chr17:31109184-31109304,chr17:31110776-31110896,chr17:31112163-31112283,chr17:31112685-31112805,chr17:31113123-31113243,chr17:31114203-31114323,chr17:31115283-31115403,chr17:31116265-31116385,chr17:31117260-31117380,chr17:31117739-31117859,chr17:31118184-31118304,chr17:31120779-31120899,chr17:31122184-31122304,chr17:31122684-31122804,chr17:31123184-31123304,chr17:31125184-31125304,chr17:31126191-31126311,chr17:31126791-31126911,chr17:31127751-31127871,chr17:31130684-31130804,chr17:31132571-31132691,chr17:31134185-31134305,chr17:31134684-31134804,chr17:31135184-31135304,chr17:31135684-31135804,chr17:31137239-31137359,chr17:31137684-31137804,chr17:31139684-31139804,chr17:31140184-31140304,chr17:31141282-31141402,chr17:31142184-31142304,chr17:31143128-31143248,chr17:31143680-31143800,chr17:31144184-31144304,chr17:31144684-31144804,chr17:31145684-31145804,chr17:31147184-31147304,chr17:31149180-31149300,chr17:31149684-31149804,chr17:31150139-31150259,chr17:31150619-31150739,chr17:31152184-31152304,chr17:31152684-31152804,chr17:31153184-31153304,chr17:31154635-31154755,chr17:31155184-31155304,chr17:31155684-31155804,chr17:31156184-31156304,chr17:31156684-31156804,chr17:31157268-31157388,chr17:31158185-31158305,chr17:31158684-31158804,chr17:31159184-31159304,chr17:31159684-31159804,chr17:31160684-31160804,chr17:31161184-31161304,chr17:31162071-31162191,chr17:31162684-31162804,chr17:31163184-31163304,chr17:31163684-31163804,chr17:31164538-31164658,chr17:31165589-31165709,chr17:31166184-31166304,chr17:31166684-31166804,chr17:31167184-31167304,chr17:31167684-31167804,chr17:31168684-31168804,chr17:31169184-31169304,chr17:31170184-31170304,chr17:31170684-31170804,chr17:31171184-31171304,chr17:31171684-31171804,chr17:31172707-31172827,chr17:31173614-31173734,chr17:31174073-31174193,chr17:31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PALB2：
chr16:23602948-23603068,chr16:23603448-23603568,chr16:23605063-23605183,chr16:23606013-23606133,chr16:23606448-23606568,chr16:23607565-23607685,chr16:23608442-23608562,chr16:23609061-23609181,chr16:23610585-23610705,chr16:23610657-23610777,chr16:23611948-23612068,chr16:23613948-23614068,chr16:23614448-23614568,chr16:23615948-23616068,chr16:23616448-23616568,chr16:23617340-23617460,chr16:23618488-23618608,chr16:23618948-23619068,chr16:23619497-23619617,chr16:23620058-23620178,chr16:23621448-23621568,chr16:23622032-23622152,chr16:23622948-23623068,chr16:23623948-23624068,chr16:23624948-23625068,chr16:23626448-23626568,chr16:23626948-23627068,chr16:23627497-23627617,chr16:23628448-23628568,chr16:23628949-23629069,chr16:23629448-23629568,chr16:23629948-23630068,chr16:23630448-23630568,chr16:23631551-23631671,chr16:23633452-23633572,chr16:23633984-23634104,chr16:23634948-23635068,chr16:23635448-23635568,chr16:23635948-23636068,chr16:23636448-23636568,chr16:23637948-23638068,chr16:23638448-23638568,chr16:23639017-23639137,chr16:23639948-23640068,chr16:23640513-23640633,chr16:23640948-23641068,chr16:23641448-23641568；
PGR：
chr11:101029335-101029455,chr11:101029835-101029955,chr11:101030335-101030455,chr11:101030835-101030955,chr11:101031335-101031455,chr11:101031835-101031955,chr11:101032335-101032455,chr11:101032835-101032955,chr11:101033335-101033455,chr11:101033835-101033955,chr11:101034335-101034455,chr11:101034835-101034955,chr11:101035335-101035455,chr11:101035835-101035955,chr11:101036335-101036455,chr11:101036835-101036955,chr11:101037311-101037431,chr11:101037819-101037939,chr11:101038335-101038455,chr11:101038835-101038955,chr11:101039335-101039455,chr11:101039885-101040005,chr11:101040835-101040955,chr11:101041285-101041405,chr11:101041835-101041955,chr11:101042335-101042455,chr11:101045219-101045339,chr11:101045928-101046048,chr11:101046429-101046549,chr11:101047335-101047455,chr11:101047834-101047954,chr11:101049835-101049955,chr11:101050335-101050455,chr11:101050879-101050999,chr11:101051335-101051455,chr11:101052335-101052455,chr11:101052835-101052955,chr11:101053335-101053455,chr11:101053836-101053956,chr11:101054335-101054455,chr11:101054836-101054956,chr11:101055423-101055543,chr11:101056256-101056376,chr11:101056835-101056955,chr11:101057300-101057420,chr11:101057780-101057900,chr11:101058335-101058455,chr11:101058835-101058955,chr11:101059335-101059455,chr11:101059850-101059970,chr11:101060335-101060455,chr11:101060835-101060955,chr11:101061335-101061455,chr11:101061835-101061955,chr11:101062335-101062455,chr11:101062835-101062955,chr11:101064341-101064461,chr11:101065335-101065455,chr11:101065835-101065955,chr11:101066335-101066455,chr11:101066835-101066955,chr11:101067378-101067498,chr11:101067835-101067955,chr11:101076451-101076571,chr11:101077335-101077455,chr11:101077835-101077955,chr11:101078335-101078455,chr11:101078800-101078920,chr11:101080335-101080455,chr11:101080835-101080955,chr11:101084835-101084955,chr11:101089368-101089488,chr11:101089819-101089939,chr11:101090335-101090455,chr11:101090798-101090918,chr11:101091260-101091380,chr11:101091835-101091955,chr11:101092335-101092455,chr11:101092835-101092955,chr11:101093335-101093455,chr11:101093835-101093955,chr11:101094335-101094455,chr11:101094835-101094955,chr11:101096335-101096455,chr11:101096835-101096955,chr11:101097353-101097473,chr11:101098335-101098455,chr11:101098835-101098955,chr11:101099835-101099955,chr11:101100448-101100568,chr11:101100946-101101066,chr11:101101786-101101906,chr11:101102375-101102495,chr11:101103335-101103455,chr11:101103792-101103912,chr11:101104335-101104455,chr11:101104835-101104955,chr11:101105310-101105430,chr11:101107335-101107455,chr11:101107835-101107955,chr11:101108447-101108567,chr11:101111335-101111455,chr11:101111835-101111955,chr11:101112335-101112455,chr11:101112835-101112955,chr11:101113835-101113955,chr11:101114335-101114455,chr11:101114835-101114955,chr11:101115295-101115415,chr11:101115789-101115909,chr11:101116335-101116455,chr11:101116796-101116916,chr11:101117363-101117483,chr11:101118335-101118455,chr11:101118827-101118947,chr11:101119335-101119455,chr11:101119806-101119926,chr11:101120335-101120455,chr11:101120802-101120922,chr11:101121335-101121455,chr11:101122335-101122455,chr11:101122835-101122955,chr11:101123335-101123455,chr11:101123814-101123934,chr11:101124335-101124455,chr11:101124835-101124955,chr11:101125335-101125455,chr11:101125835-101125955,chr11:101126335-101126455,chr11:101126835-101126955,chr11:101127335-101127455,chr11:101127835-101127955,chr11:101128335-101128455,chr11:101128835-101128955,chr11:101129335-101129455,chr11:101129835-101129955,chr11:101130335-101130455,chr11:101130835-101130955；
PIK3CA：
chr3:179148043-179148163,chr3:179148543-179148663,chr3:179149043-179149163,chr3:179149543-179149663,chr3:179150043-179150163,chr3:179150543-179150663,chr3:179151043-179151163,chr3:179151561-179151681,chr3:179152044-179152164,chr3:179152618-179152738,chr3:179153043-179153163,chr3:179153653-179153773,chr3:179154544-179154664,chr3:179155043-179155163,chr3:179156043-179156163,chr3:179156543-179156663,chr3:179157043-179157163,chr3:179157543-179157663,chr3:179158044-179158164,chr3:179158543-179158663,chr3:179159043-179159163,chr3:179160545-179160665,chr3:179161043-179161163,chr3:179162043-179162163,chr3:179163043-179163163,chr3:179163543-179163663,chr3:179164043-179164163,chr3:179164488-179164608,chr3:179165076-179165196,chr3:179165544-179165664,chr3:179166558-179166678,chr3:179167043-179167163,chr3:179168014-179168134,chr3:179169043-179169163,chr3:179169543-179169663,chr3:179170079-179170199,chr3:179170524-179170644,chr3:179171043-179171163,chr3:179171543-179171663,chr3:179172043-179172163,chr3:179172543-179172663,chr3:179173043-179173163,chr3:179173581-179173701,chr3:179174044-179174164,chr3:179174465-179174585,chr3:179175043-179175163,chr3:179175543-179175663,chr3:179176043-179176163,chr3:179176510-179176630,chr3:179177043-179177163,chr3:179177590-179177710,chr3:179178043-179178163,chr3:179178592-179178712,chr3:179179072-179179192,chr3:179179643-179179763,chr3:179180543-179180663,chr3:179181043-179181163,chr3:179181543-179181663,chr3:179182043-179182163,chr3:179182659-179182779,chr3:179183543-179183663,chr3:179184107-179184227,chr3:179184543-179184663,chr3:179185043-179185163,chr3:179186543-179186663,chr3:179187043-179187163,chr3:179188043-179188163,chr3:179188543-179188663,chr3:179189543-179189663,chr3:179190043-179190163,chr3:179190543-179190663,chr3:179191043-179191163,chr3:179191528-179191648,chr3:179192491-179192611,chr3:179193043-179193163,chr3:179193543-179193663,chr3:179194043-179194163,chr3:179194543-179194663,chr3:179195043-179195163,chr3:179196043-179196163,chr3:179196543-179196663,chr3:179197576-179197696,chr3:179198043-179198163,chr3:179198543-179198663,chr3:179199043-179199163,chr3:179199543-179199663,chr3:179200069-179200189,chr3:179200543-179200663,chr3:179201043-179201163,chr3:179201512-179201632,chr3:179201958-179202078,chr3:179202543-179202663,chr3:179203543-179203663,chr3:179204043-179204163,chr3:179204543-179204663,chr3:179205543-179205663,chr3:179205989-179206109,chr3:179206544-179206664,chr3:179207043-179207163,chr3:179208046-179208166,chr3:179208576-179208696,chr3:179209543-179209663,chr3:179210043-179210163,chr3:179210543-179210663,chr3:179213044-179213164,chr3:179215043-179215163,chr3:179215543-179215663,chr3:179217043-179217163,chr3:179217543-179217663,chr3:179218043-179218163,chr3:179218543-179218663,chr3:179219043-179219163,chr3:179219543-179219663,chr3:179220043-179220163,chr3:179220543-179220663,chr3:179221043-179221163,chr3:179221543-179221663,chr3:179222043-179222163,chr3:179223043-179223163,chr3:179223522-179223642,chr3:179224043-179224163,chr3:179224543-179224663,chr3:179225011-179225131,chr3:179225543-179225663,chr3:179226043-179226163,chr3:179226543-179226663,chr3:179227043-179227163,chr3:179227543-179227663,chr3:179228543-179228663,chr3:179229043-179229163,chr3:179229543-179229663,chr3:179230043-179230163,chr3:179233543-179233663,chr3:179234044-179234164,chr3:179234543-179234663,chr3:179235043-179235163,chr3:179235543-179235663,chr3:179236043-179236163,chr3:179236543-179236663,chr3:179237043-179237163,chr3:179237543-179237663,chr3:179238043-179238163,chr3:179238543-179238663,chr3:179239043-179239163,chr3:179239543-179239663,chr3:179240043-179240163；
RAD50：
chr5:132555873-132555993,chr5:132556310-132556430,chr5:132556873-132556993,chr5:132557373-132557493,chr5:132557873-132557993,chr5:132558992-132559112,chr5:132559902-132560022,chr5:132560336-132560456,chr5:132560873-132560993,chr5:132561862-132561982,chr5:132562373-132562493,chr5:132562873-132562993,chr5:132563373-132563493,chr5:132565373-132565493,chr5:132565873-132565993,chr5:132566373-132566493,chr5:132566955-132567075,chr5:132567873-132567993,chr5:132568422-132568542,chr5:132569373-132569493,chr5:132571339-132571459,chr5:132571873-132571993,chr5:132572936-132573056,chr5:132575436-132575556,chr5:132575873-132575993,chr5:132576373-132576493,chr5:132576812-132576932,chr5:132577490-132577610,chr5:132578328-132578448,chr5:132578873-132578993,chr5:132579373-132579493,chr5:132579873-132579993,chr5:132580373-132580493,chr5:132580873-132580993,chr5:132581397-132581517,chr5:132581873-132581993,chr5:132582416-132582536,chr5:132582873-132582993,chr5:132585373-132585493,chr5:132586873-132586993,chr5:132587438-132587558,chr5:132587873-132587993,chr5:132588373-132588493,chr5:132588873-132588993,chr5:132589873-132589993,chr5:132590466-132590586,chr5:132591373-132591493,chr5:132591873-132591993,chr5:132593402-132593522,chr5:132593873-132593993,chr5:132594438-132594558,chr5:132594873-132594993,chr5:132595373-132595493,chr5:132595873-132595993,chr5:132596373-132596493,chr5:132596873-132596993,chr5:132597373-132597493,chr5:132597873-132597993,chr5:132598317-132598437,chr5:132598922-132599042,chr5:132599886-132600006,chr5:132600474-132600594,chr5:132601373-132601493,chr5:132602373-132602493,chr5:132602798-132602918,chr5:132603373-132603493,chr5:132603873-132603993,chr5:132604873-132604993,chr5:132607383-132607503,chr5:132607873-132607993,chr5:132608873-132608993,chr5:132609373-132609493,chr5:132609873-132609993,chr5:132610373-132610493,chr5:132610804-132610924,chr5:132611402-132611522,chr5:132611873-132611993,chr5:132612839-132612959,chr5:132613374-132613494,chr5:132614362-132614482,chr5:132614873-132614993,chr5:132615373-132615493,chr5:132615873-132615993,chr5:132616373-132616493,chr5:132616873-132616993,chr5:132617316-132617436,chr5:132617873-132617993,chr5:132618873-132618993,chr5:132619304-132619424,chr5:132620355-132620475,chr5:132621873-132621993,chr5:132622833-132622953,chr5:132623873-132623993,chr5:132624373-132624493,chr5:132624874-132624994,chr5:132625299-132625419,chr5:132626449-132626569,chr5:132627272-132627392,chr5:132627873-132627993,chr5:132628348-132628468,chr5:132628944-132629064,chr5:132629373-132629493,chr5:132629873-132629993,chr5:132630373-132630493,chr5:132630966-132631086,chr5:132631399-132631519,chr5:132631874-132631994,chr5:132632360-132632480,chr5:132632823-132632943,chr5:132633423-132633543,chr5:132633903-132634023,chr5:132634373-132634493,chr5:132634966-132635086,chr5:132635873-132635993,chr5:132636373-132636493,chr5:132636873-132636993,chr5:132637373-132637493,chr5:132637873-132637993,chr5:132638373-132638493,chr5:132638873-132638993,chr5:132639373-132639493,chr5:132639873-132639993,chr5:132640373-132640493,chr5:132640873-132640993,chr5:132641373-132641493,chr5:132641873-132641993,chr5:132642373-132642493,chr5:132643373-132643493,chr5:132643873-132643993,chr5:132644434-132644554,chr5:132645394-132645514；
RAD51B：
chr14:67819688-67819808,chr14:67820111-67820231,chr14:67820688-67820808,chr14:67821301-67821421,chr14:67821731-67821851,chr14:67822188-67822308,chr14:67822720-67822840,chr14:67823188-67823308,chr14:67823688-67823808,chr14:67824688-67824808,chr14:67825188-67825308,chr14:67825641-67825761,chr14:67826188-67826308,chr14:67827188-67827308,chr14:67829654-67829774,chr14:67830188-67830308,chr14:67830734-67830854,chr14:67831214-67831334,chr14:67832689-67832809,chr14:67833763-67833883,chr14:67834188-67834308,chr14:67835188-67835308,chr14:67836188-67836308,chr14:67836798-67836918,chr14:67838257-67838377,chr14:67838739-67838859,chr14:67839188-67839308,chr14:67839688-67839808,chr14:67844188-67844308,chr14:67846188-67846308,chr14:67846688-67846808,chr14:67850259-67850379,chr14:67850698-67850818,chr14:67851188-67851308,chr14:67851651-67851771,chr14:67852188-67852308,chr14:67852731-67852851,chr14:67853688-67853808,chr14:67854945-67855065,chr14:67855689-67855809,chr14:67856192-67856312,chr14:67856688-67856808,chr14:67857188-67857308,chr14:67857620-67857740,chr14:67858792-67858912,chr14:67859733-67859853,chr14:67860188-67860308,chr14:67861173-67861293,chr14:67861688-67861808,chr14:67862262-67862382,chr14:67862688-67862808,chr14:67863688-67863808,chr14:67864214-67864334,chr14:67865144-67865264,chr14:67866309-67866429,chr14:67867160-67867280,chr14:67867688-67867808,chr14:67874188-67874308,chr14:67874688-67874808,chr14:67875188-67875308,chr14:67875731-67875851,chr14:67876188-67876308,chr14:67876688-67876808,chr14:67877131-67877251,chr14:67878188-67878308,chr14:67879188-67879308,chr14:67880188-67880308,chr14:67880688-67880808,chr14:67881205-67881325,chr14:67881685-67881805,chr14:67882285-67882405,chr14:67883133-67883253,chr14:67883688-67883808,chr14:67884188-67884308,chr14:67884688-67884808,chr14:67885188-67885308,chr14:67885688-67885808,chr14:67886109-67886229,chr14:67886741-67886861,chr14:67887235-67887355,chr14:67887688-67887808,chr14:67888188-67888308,chr14:67889188-67889308,chr14:67889688-67889808,chr14:67890688-67890808,chr14:67891188-67891308,chr14:67891688-67891808,chr14:67892188-67892308,chr14:67892688-67892808,chr14:67893183-67893303,chr14:67893688-67893808,chr14:67894179-67894299,chr14:67894679-67894799,chr14:67895188-67895308,chr14:67895689-67895809,chr14:67896188-67896308,chr14:67896688-67896808,chr14:67898697-67898817,chr14:67899607-67899727,chr14:67900188-67900308,chr14:67900688-67900808,chr14:67901188-67901308,chr14:67902205-67902325,chr14:67902688-67902808,chr14:67903188-67903308,chr14:67907811-67907931,chr14:67908265-67908385,chr14:67909188-67909308,chr14:67910188-67910308,chr14:67910688-67910808,chr14:67911188-67911308,chr14:67911785-67911905,chr14:67912611-67912731,chr14:67913132-67913252,chr14:67914581-67914701,chr14:67915221-67915341,chr14:67915688-67915808,chr14:67916171-67916291,chr14:67916688-67916808,chr14:67917688-67917808,chr14:67918136-67918256,chr14:67918688-67918808,chr14:67919168-67919288,chr14:67919779-67919899,chr14:67920797-67920917,chr14:67922148-67922268,chr14:67927119-67927239,chr14:67927703-67927823,chr14:67930188-67930308,chr14:67932727-67932847,chr14:67934188-67934308,chr14:67934688-67934808,chr14:67935188-67935308,chr14:67935688-67935808,chr14:67936188-67936308,chr14:67936688-67936808,chr14:67937253-67937373,chr14:67937688-67937808,chr14:67938188-67938308,chr14:67938710-67938830,chr14:67939188-67939308,chr14:67939688-67939808,chr14:67940621-67940741,chr14:67941188-67941308,chr14:67941688-67941808,chr14:67942188-67942308,chr14:67942688-67942808,chr14:67943189-67943309,chr14:67943722-67943842,chr14:67944188-67944308,chr14:67945196-67945316,chr14:67946188-67946308,chr14:67946688-67946808,chr14:67947188-67947308,chr14:67947688-67947808,chr14:67948188-67948308,chr14:67950744-67950864,chr14:67951196-67951316,chr14:67951688-67951808,chr14:67952306-67952426,chr14:67953092-67953212,chr14:67954188-67954308,chr14:67954688-67954808,chr14:67955108-67955228,chr14:67955705-67955825,chr14:67957189-67957309,chr14:67957688-67957808,chr14:67958188-67958308,chr14:67958688-67958808,chr14:67959154-67959274,chr14:67959688-67959808,chr14:67960188-67960308,chr14:67961283-67961403,chr14:67962188-67962308,chr14:67962688-67962808,chr14:67963209-67963329,chr14:67963688-67963808,chr14:67964188-67964308,chr14:67964688-67964808,chr14:67965188-67965308,chr14:67965688-67965808,chr14:67966188-67966308,chr14:67969205-67969325,chr14:67969688-67969808,chr14:67970188-67970308,chr14:67970688-67970808,chr14:67971188-67971308,chr14:67971678-67971798,chr14:67972188-67972308,chr14:67972688-67972808,chr14:67973188-67973308,chr14:67973688-67973808,chr14:67974188-67974308,chr14:67974688-67974808,chr14:67975188-67975308,chr14:67977188-67977308,chr14:67977688-67977808,chr14:67978188-67978308,chr14:67978688-67978808,chr14:67979688-67979808,chr14:67980688-67980808,chr14:67981126-67981246,chr14:67981726-67981846,chr14:67982681-67982801,chr14:67983188-67983308,chr14:67983688-67983808,chr14:67984216-67984336,chr14:67984641-67984761,chr14:67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chr14:68664188-68664308,chr14:68664688-68664808,chr14:68665188-68665308,chr14:68665669-68665789,chr14:68666688-68666808,chr14:68667188-68667308,chr14:68668188-68668308,chr14:68668688-68668808,chr14:68669188-68669308,chr14:68669688-68669808,chr14:68670188-68670308,chr14:68670688-68670808,chr14:68671188-68671308,chr14:68671796-68671916,chr14:68672688-68672808,chr14:68673172-68673292,chr14:68673688-68673808,chr14:68674252-68674372,chr14:68674688-68674808,chr14:68675188-68675308,chr14:68675688-68675808,chr14:68676688-68676808,chr14:68677188-68677308,chr14:68677688-68677808,chr14:68678189-68678309,chr14:68678739-68678859,chr14:68679688-68679808,chr14:68680688-68680808,chr14:68681188-68681308,chr14:68681688-68681808,chr14:68682188-68682308,chr14:68682688-68682808,chr14:68683188-68683308,chr14:68683688-68683808,chr14:68684300-68684420,chr14:68685188-68685308,chr14:68685688-68685808,chr14:68686188-68686308,chr14:68687188-68687308,chr14:68687651-68687771,chr14:68688688-68688808,chr14:68689188-68689308,chr14:68689688-68689808,chr14:68690188-68690308,chr14:68690688-68690808,chr14:68691188-68691308,chr14:68691688-68691808,chr14:68692188-68692308,chr14:68692715-68692835,chr14:68693188-68693308,chr14:68693688-68693808,chr14:68694188-68694308,chr14:68694688-68694808,chr14:68695188-68695308,chr14:68695688-68695808,chr14:68696200-68696320,chr14:68696688-68696808,chr14:68697188-68697308,chr14:68699688-68699808,chr14:68702188-68702308,chr14:68702689-68702809,chr14:68703188-68703308,chr14:68703736-68703856,chr14:68704189-68704309,chr14:68704689-68704809,chr14:68705188-68705308,chr14:68705688-68705808,chr14:68706188-68706308,chr14:68706688-68706808,chr14:68707248-68707368,chr14:68707688-68707808,chr14:68708188-68708308,chr14:68708661-68708781,chr14:68709104-68709224,chr14:68709793-68709913,chr14:68710688-68710808,chr14:68711188-68711308,chr14:68711688-68711808,chr14:68712688-68712808,chr14:68713188-68713308,chr14:68713688-68713808,chr14:68714188-68714308,chr14:68714779-68714899,chr14:68715750-68715870,chr14:68716688-68716808,chr14:68717249-68717369,chr14:68717688-68717808,chr14:68718144-68718264,chr14:68718614-68718734,chr14:68719107-68719227,chr14:68719688-68719808,chr14:68720188-68720308,chr14:68721188-68721308,chr14:68721688-68721808,chr14:68722141-68722261,chr14:68722754-68722874,chr14:68723188-68723308,chr14:68723688-68723808,chr14:68724188-68724308,chr14:68725164-68725284,chr14:68725688-68725808,chr14:68726688-68726808,chr14:68727190-68727310,chr14:68727688-68727808,chr14:68728188-68728308,chr14:68728703-68728823,chr14:68729688-68729808,chr14:68730188-68730308；
RAD51C：
chr17:58692263-58692383,chr17:58692763-58692883,chr17:58693263-58693383,chr17:58693850-58693970,chr17:58694763-58694883,chr17:58695263-58695383,chr17:58696763-58696883,chr17:58699320-58699440,chr17:58700314-58700434,chr17:58700763-58700883,chr17:58701842-58701962,chr17:58702263-58702383,chr17:58703263-58703383,chr17:58704730-58704850,chr17:58705690-58705810,chr17:58708847-58708967,chr17:58709356-58709476,chr17:58710763-58710883,chr17:58711263-58711383,chr17:58711764-58711884,chr17:58712349-58712469,chr17:58713236-58713356,chr17:58714277-58714397,chr17:58715728-58715848,chr17:58716237-58716357,chr17:58717764-58717884,chr17:58718275-58718395,chr17:58718763-58718883,chr17:58719675-58719795,chr17:58720763-58720883,chr17:58721265-58721385,chr17:58721764-58721884,chr17:58722232-58722352,chr17:58722763-58722883,chr17:58723250-58723370,chr17:58723763-58723883,chr17:58724263-58724383,chr17:58724763-58724883,chr17:58725263-58725383,chr17:58726263-58726383,chr17:58727403-58727523,chr17:58728264-58728384,chr17:58728763-58728883,chr17:58729850-58729970,chr17:58730680-58730800,chr17:58731860-58731980,chr17:58732763-58732883,chr17:58733294-58733414,chr17:58734263-58734383,chr17:58734874-58734994；
RAD51D：
chr17:35092054-35092174,chr17:35092646-35092766,chr17:35093523-35093643,chr17:35094005-35094125,chr17:35094554-35094674,chr17:35095980-35096100,chr17:35096460-35096580,chr17:35097024-35097144,chr17:35097555-35097675,chr17:35098054-35098174,chr17:35099133-35099253,chr17:35099554-35099674,chr17:35100054-35100174,chr17:35100554-35100674,chr17:35101054-35101174,chr17:35102062-35102182,chr17:35102635-35102755,chr17:35103055-35103175,chr17:35103554-35103674,chr17:35104079-35104199,chr17:35104663-35104783,chr17:35105113-35105233,chr17:35105554-35105674,chr17:35106036-35106156,chr17:35106487-35106607,chr17:35107054-35107174,chr17:35107554-35107674,chr17:35108594-35108714,chr17:35113054-35113174,chr17:35113555-35113675,chr17:35115054-35115174,chr17:35116054-35116174,chr17:35116954-35117074,chr17:35118012-35118132,chr17:35118554-35118674,chr17:35119055-35119175,chr17:35119554-35119674,chr17:35120599-35120719,chr17:35121054-35121174,chr17:35121554-35121674；
RECQL4：
chr8:144511004-144511124,chr8:144511487-144511607,chr8:144512004-144512124,chr8:144512504-144512624,chr8:144513004-144513124,chr8:144513503-144513623,chr8:144514003-144514123,chr8:144514503-144514623,chr8:144515003-144515123,chr8:144515503-144515623,chr8:144516003-144516123,chr8:144516503-144516623,chr8:144517003-144517123,chr8:144517476-144517596,chr8:144518003-144518123；
RECQL5：
chr17:75626707-75626827,chr17:75627207-75627327,chr17:75627640-75627760,chr17:75628207-75628327,chr17:75628707-75628827,chr17:75629207-75629327,chr17:75629707-75629827,chr17:75630207-75630327,chr17:75630707-75630827,chr17:75631207-75631327,chr17:75631652-75631772,chr17:75632707-75632827,chr17:75633207-75633327,chr17:75633707-75633827,chr17:75634207-75634327,chr17:75634707-75634827,chr17:75635207-75635327,chr17:75635707-75635827,chr17:75636207-75636327,chr17:75636707-75636827,chr17:75637207-75637327,chr17:75637707-75637827,chr17:75638707-75638827,chr17:75639207-75639327,chr17:75639707-75639827,chr17:75640207-75640327,chr17:75640692-75640812,chr17:75641207-75641327,chr17:75641707-75641827,chr17:75642207-75642327,chr17:75643207-75643327,chr17:75643632-75643752,chr17:75644590-75644710,chr17:75645166-75645286,chr17:75645646-75645766,chr17:75646207-75646327,chr17:75646707-75646827,chr17:75647207-75647327,chr17:75647707-75647827,chr17:75648270-75648390,chr17:75649207-75649327,chr17:75649707-75649827,chr17:75650207-75650327,chr17:75650707-75650827,chr17:75651207-75651327,chr17:75651707-75651827,chr17:75652235-75652355,chr17:75652707-75652827,chr17:75653207-75653327,chr17:75654207-75654327,chr17:75655070-75655190,chr17:75656636-75656756,chr17:75657207-75657327,chr17:75658207-75658327,chr17:75659784-75659904,chr17:75660707-75660827,chr17:75661328-75661448,chr17:75662207-75662327,chr17:75662707-75662827,chr17:75663644-75663764,chr17:75664207-75664327,chr17:75665275-75665395,chr17:75665708-75665828,chr17:75666256-75666376,chr17:75666707-75666827,chr17:75667207-75667327；
WRN：
chr8:31033028-31033148,chr8:31033528-31033648,chr8:31034028-31034148,chr8:31034515-31034635,chr8:31035073-31035193,chr8:31035634-31035754,chr8:31038528-31038648,chr8:31040028-31040148,chr8:31040528-31040648,chr8:31040982-31041102,chr8:31041582-31041702,chr8:31042028-31042148,chr8:31042528-31042648,chr8:31043033-31043153,chr8:31043528-31043648,chr8:31045029-31045149,chr8:31046047-31046167,chr8:31046528-31046648,chr8:31047028-31047148,chr8:31047528-31047648,chr8:31048028-31048148,chr8:31048552-31048672,chr8:31049528-31049648,chr8:31050140-31050260,chr8:31050580-31050700,chr8:31051028-31051148,chr8:31052122-31052242,chr8:31053028-31053148,chr8:31053528-31053648,chr8:31054028-31054148,chr8:31054541-31054661,chr8:31056028-31056148,chr8:31056528-31056648,chr8:31057028-31057148,chr8:31057576-31057696,chr8:31058028-31058148,chr8:31058528-31058648,chr8:31059028-31059148,chr8:31059528-31059648,chr8:31060057-31060177,chr8:31060542-31060662,chr8:31061028-31061148,chr8:31061528-31061648,chr8:31062028-31062148,chr8:31063058-31063178,chr8:31063528-31063648,chr8:31064480-31064600,chr8:31065028-31065148,chr8:31066528-31066648,chr8:31067028-31067148,chr8:31067528-31067648,chr8:31068028-31068148,chr8:31068528-31068648,chr8:31069028-31069148,chr8:31070016-31070136,chr8:31071063-31071183,chr8:31072023-31072143,chr8:31072592-31072712,chr8:31073028-31073148,chr8:31073528-31073648,chr8:31074528-31074648,chr8:31075028-31075148,chr8:31075528-31075648,chr8:31076028-31076148,chr8:31076528-31076648,chr8:31077028-31077148,chr8:31077528-31077648,chr8:31078413-31078533,chr8:31079028-31079148,chr8:31079528-31079648,chr8:31080528-31080648,chr8:31081028-31081148,chr8:31081533-31081653,chr8:31082040-31082160,chr8:31082505-31082625,chr8:31082999-31083119,chr8:31083562-31083682,chr8:31084472-31084592,chr8:31085029-31085149,chr8:31086028-31086148,chr8:31087028-31087148,chr8:31087528-31087648,chr8:31088028-31088148,chr8:31088528-31088648,chr8:31089028-31089148,chr8:31089463-31089583,chr8:31090136-31090256,chr8:31091028-31091148,chr8:31091564-31091684,chr8:31092028-31092148,chr8:31092599-31092719,chr8:31095028-31095148,chr8:31095528-31095648,chr8:31096528-31096648,chr8:31097484-31097604,chr8:31098028-31098148,chr8:31098528-31098648,chr8:31099437-31099557,chr8:31100028-31100148,chr8:31100589-31100709,chr8:31101028-31101148,chr8:31102028-31102148,chr8:31104528-31104648,chr8:31105028-31105148,chr8:31106028-31106148,chr8:31106571-31106691,chr8:31107141-31107261,chr8:31108028-31108148,chr8:31108528-31108648,chr8:31109028-31109148,chr8:31109518-31109638,chr8:31110028-31110148,chr8:31110528-31110648,chr8:31111028-31111148,chr8:31111528-31111648,chr8:31111949-31112069,chr8:31112504-31112624,chr8:31113528-31113648,chr8:31114028-31114148,chr8:31114528-31114648,chr8:31115591-31115711,chr8:31116127-31116247,chr8:31117029-31117149,chr8:31117528-31117648,chr8:31118028-31118148,chr8:31118528-31118648,chr8:31119028-31119148,chr8:31119528-31119648,chr8:31120028-31120148,chr8:31120528-31120648,chr8:31121028-31121148,chr8:31121528-31121648,chr8:31122028-31122148,chr8:31122529-31122649,chr8:31123528-31123648,chr8:31124028-31124148,chr8:31124528-31124648,chr8:31125028-31125148,chr8:31125501-31125621,chr8:31125981-31126101,chr8:31126581-31126701,chr8:31127488-31127608,chr8:31128480-31128600,chr8:31128931-31129051,chr8:31129623-31129743,chr8:31130143-31130263,chr8:31131528-31131648,chr8:31132028-31132148,chr8:31132528-31132648,chr8:31133028-31133148,chr8:31133529-31133649,chr8:31134028-31134148,chr8:31134528-31134648,chr8:31134991-31135111,chr8:31135528-31135648,chr8:31136459-31136579,chr8:31137028-31137148,chr8:31137523-31137643,chr8:31138092-31138212,chr8:31138541-31138661,chr8:31139028-31139148,chr8:31139528-31139648,chr8:31140528-31140648,chr8:31141028-31141148,chr8:31141528-31141648,chr8:31142528-31142648,chr8:31143078-31143198,chr8:31143528-31143648,chr8:31146028-31146148,chr8:31146595-31146715,chr8:31147028-31147148,chr8:31147528-31147648,chr8:31148528-31148648,chr8:31149017-31149137,chr8:31150028-31150148,chr8:31150528-31150648,chr8:31151528-31151648,chr8:31152028-31152148,chr8:31152535-31152655,chr8:31153028-31153148,chr8:31153528-31153648,chr8:31154028-31154148,chr8:31154528-31154648,chr8:31155028-31155148,chr8:31155620-31155740,chr8:31156528-31156648,chr8:31157028-31157148,chr8:31157528-31157648,chr8:31158028-31158148,chr8:31158528-31158648,chr8:31159529-31159649,chr8:31160028-31160148,chr8:31160528-31160648,chr8:31160995-31161115,chr8:31163028-31163148,chr8:31163528-31163648,chr8:31164117-31164237,chr8:31165029-31165149,chr8:31166028-31166148,chr8:31166528-31166648,chr8:31167028-31167148,chr8:31167528-31167648,chr8:31168028-31168148,chr8:31168528-31168648,chr8:31169028-31169148,chr8:31169528-31169648,chr8:31170028-31170148,chr8:31170528-31170648,chr8:31171528-31171648,chr8:31172028-31172148,chr8:31172528-31172648,chr8:31173028-31173148,chr8:31173528-31173648,chr8:31174106-31174226,chr8:31174995-31175115,chr8:31175528-31175648。
the concrete operation is as follows
A probe composition, a kit and a sequencing method of breast cancer genes comprise the following steps:
1) Construction of genomic DNA library: extracting genome DNA in a sample to be detected, and breaking the genome DNA into fragments with the size of 2-10k, preferably about 5 k; after the two ends of the double-stranded DNA fragment after being broken are subjected to end repair, connecting an upper joint sequence; obtaining a DNA library;
2) Pre-amplification of DNA library: carrying out primary PCR amplification on the DNA fragments with the joints in the DNA library by adopting a primer of a targeting joint sequence to obtain a pre-amplified DNA library;
3) Hybridization capture target sequence: after denaturing the double-stranded DNA fragments in the pre-amplified DNA library, hybridized capture of the target sequence using a detection probe (as described previously);
4) Target sequence elution and second PCR amplification: eluting the target sequence captured in the previous step, and carrying out PCR amplification on the eluted target sequence for the second time;
5) Constructing a third-generation sequencing library of the product of the second PCR amplification;
6) Sequencing the third-generation library by a third-generation sequencer;
7) And carrying out bioinformatics analysis on the third-generation sequencing data to obtain a nucleic acid molecule sequence related to the breast cancer gene, and further determining the sequence condition of Structural Variation (SVs) in the sample to be detected.
The invention realizes the screening of breast cancer genes with low cost, high flux and short period by carefully designing the long fragment capturing and amplifying technology of the breast cancer related genes and combining the three-generation long reading and long sequencing technology. The method can detect 20 genes related to high risk groups of breast cancer and 8 genes related to accurate treatment of breast cancer at one time, effectively improve the coverage of a target gene sequence while improving the utilization rate of sequencing data and reducing the cost, and simultaneously can detect 28 related genes of a plurality of people by adding barcode, so that the method is fast and efficient, and is suitable for large-scale clinical sample screening.
The test materials adopted by the invention are all common commercial products and can be purchased in the market. The invention is further illustrated by the following examples:
EXAMPLE 1 library construction
1. Preparation of probe for hybrid capture of breast cancer genes
For the selected breast cancer related genes, 10Kb extends from the upstream to the downstream, one probe is designed at intervals of 500 bp-2K, and one probe is designed at an average interval of 500bp. The designed probe has the number of bases between 50 and 130bp, moderate GC content value and no hairpin structure, and further performs Blast comparison with a reference genome database to ensure the specificity of the probe. Preferably, the number of bases of the designed probe is 120bp. The breast cancer probe design reference sequence is human reference genome version Hg38, and the designed probe sequence is a breast cancer gene probe (shown in the previous description).
2. Linker sequences
The connector is composed of an A sequence and a B sequence,
the sequence A is as follows:
gcagtcgaacatgtagctgactcaggtcacNNNNNNNNNNNNNNNNggtagT(SEQ ID NO:1)；
the sequence B is as follows:
/5phos/ctaccNNNNNNNNNNNNNNNNgtgacctgagtcagctacatgttcgactgc(SEQ ID NO:2)；
the sequence of/5 phos/represents phosphorylation modification; n represents any one of four bases A/G/C/T; the a and B sequences NNNNNNNNNNNNNNNN are used to identify libraries of different sample constructions, i.e., data barcodes (barcode) for distinguishing samples.
In barcode for the same sample, linker a was reverse-complementary to NNNNNNNNNNNNNNNN in linker B.
The working joint is obtained by mixing the sequence A and the sequence B in equal molar quantity and fully denaturing and annealing.
3. Sample genomic DNA extraction and quality assessment
The genomic DNA is extracted from the sample to be tested (typically breast cancer tumor tissue and peripheral blood). The integrity of the genome was checked by agarose gel electrophoresis and the genome was subjected to concentration measurement using Qubit (Life Technologies, usa). DNA samples with relatively complete genome and concentration of 25 ng/. Mu.l or more are selected for library construction.
4. Construction of Capture library
4.1 disruption of genomic DNA
The genomic DNA was disrupted using a Covaris gTUBE with a disruption parameter of 10000g,1min.
The fragmented genomic DNA was prepared by purification using 0.6-fold volume of AMPure PB beads.
4.2 sample end repair, attach
4.2.1 terminal repair, adding "A"
A NEB Next Ultra End Repair/dA-labeling Module kit was used.
The system is as follows:
the reaction conditions are as follows:
4.2.2 Joint connection
A NEB Next Ultra II Ligation Module kit was used.
The system is as follows:
in a PCR apparatus, the reaction was carried out at 20℃for 15min. Subsequently, purification was performed using 0.6-fold volume of AMPure XP magnetic beads to obtain a library solution.
4.3 Pre-amplification of library
The reaction system is as follows:
the Primer is a Primer for library pre-amplification, and specifically comprises the following components:
Primer：gcagtcgaacatgtagctgactcaggtcac(SEQ ID NO:3)
the reaction conditions are as follows:
the PCR product was recovered using 0.6 volumes of AMPure XP magnetic beads.
4.4 hybridization Capture target sequences
4.4.1 Capture preparation
The samples to be captured were mixed in equal amounts, and the total amount of DNA was 1. Mu.g.
mu.L of Primer was added, which was aimed at blocking the linker sequences used in the construction of the library, respectively, and preventing hybridization of the two linker sequences and probes on the library.
The sequence is as follows:
gcagtcgaacatgtagctgactcaggtcac(SEQ ID NO:3)；
shaking and mixing uniformly, and then uncovering the cover, concentrating in vacuum at 60 ℃ until the cover is evaporated to dryness;
4.4.2 Capture
Hybridization buffer was prepared according to kit xGen Lockdown Reagent Kit (IDT, cat# 1072281) with the following specific system:
adding the hybridization buffer into the evaporated sample, shaking and uniformly mixing, centrifuging briefly, and placing the mixture on a PCR instrument at 95 ℃ for 10min.
After the reaction, the mixture was centrifuged, and 13. Mu.L of the sample was transferred to a PCR tube containing 4. Mu.L of a capture probe, and the mixture was then well mixed by pipetting. The sample was subjected to PCR at 65℃for 16 hours.
4.5 hybridization elution
4.5.1 elution reagent was prepared according to kit xGen Lockdown Reagent Kit (IDT, cat# 1072281):
4.5.2 capture bead treatment:
a) The 50 mu l M280 magnetic beads are sucked into a centrifuge tube, the centrifuge tube is placed on a magnetic rack, and the supernatant is discarded after the supernatant is completely clarified.
b) 200 μl of 1x Bead Wash Buffer (visual 7) was added, mixed well, centrifuged, placed on a magnetic rack until the supernatant was completely clear, and the supernatant was discarded.
c) Repeating step b once.
d) Add 100. Mu.l 1x Bead Wash Buffer (visual 7), mix well, transfer to PCR tube, place on magnetic rack until supernatant is completely clear, discard supernatant.
4.5.3 binding of magnetic beads to library of interest:
a) Mu.l of the hybridization system is added into a PCR tube with magnetic beads, and the mixture is uniformly blown and sucked up and down, and incubated for 45min at 65 ℃ on a PCR instrument.
4.5.4 elution:
a) 100 μl of 1 XWash Buffer I (visual 1) at 65deg.C was added and mixed well. Placing on a magnetic rack, discarding supernatant when the supernatant is completely clear.
b) 200 μl of 65℃1x Stringent Wash Buffer (visual 4) was added, mixed well and transferred to a preheated large centrifuge tube. Placing on Wen Yoyi at 65deg.C for 5min. Placing on a magnetic rack, discarding supernatant when the supernatant is completely clear.
c) 200 μl of 1 XWash Buffer I (visual 1) at room temperature was added and mixed well. Placing on a magnetic rack, discarding supernatant when the supernatant is completely clear.
d) 200 μl of 1 XWash Buffer II (visual 2) at room temperature was added and mixed well 1. Placing on a magnetic rack, discarding supernatant when the supernatant is completely clear.
e) 200. Mu.l of normal temperature 1x Wash Buffer III (visual 3) was added thereto and mixed well. Placing on a magnetic rack, discarding supernatant when the supernatant is completely clear.
f) The mixture was centrifuged briefly and a small amount of the remaining liquid was removed using a 10. Mu.l tip.
g) The beads were kept at-20℃using 25. Mu.l of Nuclear-free Water suspension.
4.6 optimization of hybridization library amplification reaction System and reaction conditions
The basic system and conditions for optimizing the reaction system and the reaction conditions are as follows:
the M280 magnetic bead probe suspension obtained in the last step is prepared by taking 25 mu L/library and carrying out a PCR amplification system in a 200ml PCR tube according to the following table:
primers described in the above table are identical to the primers pre-amplified in the library above:
Primer：gcagtcgaacatgtagctgactcaggtcac(SEQ ID NO:3)。
PCR reaction procedure:
4.7 library quality inspection
The library is subjected to Qkit detection and Agilent 2100Bioanalyzer detection, and the qualified library is subjected to the next three-generation sequencing library construction.
5. Construction condition optimization
(1) Optimization of primer concentration: under the same other conditions of the reaction system, the concentrations of the primers were adjusted to be 0.5. Mu.M, 1. Mu.M, 1.5. Mu.M, 2. Mu.M, 2.5. Mu.M and 3. Mu.M, respectively. Other reaction conditions are the same as those of the above 1 to 4.
As a result, it was found that the amplification effect of the reaction system was best at a primer concentration of 2. Mu.M, and that the optimum primer concentration in the reaction system was determined to be 2. Mu.M.
(2) Optimization of Betaine concentration: under the condition that other conditions of the reaction system are the same, the concentration of the Betaine is adjusted, and the concentration of the Betaine in the reaction system is respectively 0M, 0.1M, 0.3M, 1M, 3M and 5M. The reaction conditions are the same as the basic reaction conditions.
The result shows that the amplification effect of the reaction system is best when the concentration of the Betaine is 1M, and the optimal concentration of the Betaine in the reaction system is determined to be 1M.
(3) Optimization of enzymes: under the condition that other conditions of the reaction systems are the same, different DNA polymerases are used, wherein the used DNA polymerases are EXTaq DNA polymerase, pfu DNA polymerase, rTaq DNA polymerase and PrimeSTAR GXL polymerase respectively, one DNA polymerase is used in each reaction system, and the concentration of each DNA polymerase in the reaction system is the same. The reaction conditions are the same as the basic reaction conditions.
The results showed that the amplification of the reaction system of PrimeSTAR GXL polymerase was best, and the best DNA polymerase was determined to be PrimeSTAR GXL polymerase.
(4) Optimization of magnesium ion concentration: under the same conditions as the other conditions of the reaction system, the concentration of magnesium ions in the reaction system was adjusted to be 0.5mM, 1.0mM, 2.0mM, 3.0mM and 4.0mM, respectively. The reaction conditions are the same as the basic reaction conditions.
As a result, it was found that the amplification effect of the reaction system was best when the magnesium ion concentration was 2mM, and that the optimal magnesium ion concentration in the reaction system was 2mM.
(5) Optimization of annealing temperature: the reaction system was a basic reaction system, and gradient PCR was performed by adjusting the annealing temperature (the annealing temperature was 58 ℃, 60 ℃, 62 ℃ and 64 ℃ respectively) under the same other conditions of the reaction.
The result showed that the amplification effect of the reaction system was best when the annealing temperature was 62℃and the optimum annealing temperature was determined to be 62 ℃.
The basic reaction system is the optimal reaction system, and the basic reaction condition is the optimal reaction condition.
After the reaction is finished, the AMPure XP magnetic beads with the volume of 0.6 times are used for purification, and finally TE solution is used for eluting the magnetic beads, and the magnetic beads are transferred into a new centrifuge tube to enter the next operation or are placed in the temperature of minus 80 ℃ for standby.
Example 2 sequencing and results analysis
1. Third generation sequencing library construction and sequencing
1.1 sequencing Using Pacbio sequence II
1.1.1 use of a library construction kit for library construction
1.1.1.1 repair of the pooled library
Preparing a repairing solution:
mixing, centrifuging, and placing into a PCR thermal cycler for repair reaction under the following specific conditions:
5.1.1.2 joint connection
The connection solution system is as follows:
mixing, centrifuging, and performing connection reaction in a PCR thermal cycler under the following specific conditions:
1.1.1.3 purification
Purification was performed using 0.45 sample volumes of PB beads, and finally the beads were eluted with double distilled water and stored in a-20℃refrigerator.
1.1.2 primer annealing and Binding reactions
The sequencing was performed according to the standard procedure for Pacbio sequence II instrument.
1.1.3 third Generation sequencing
Sequencing was performed according to the Pacbio sequence II instrument standard operating specifications.
2. Bioinformatics analysis
2.1 data quality control and splitting
The generation of sequencing data is performed through a plurality of steps such as DNA extraction, capturing, library establishment, sequencing and the like, invalid data generated in the steps can cause serious interference to subsequent information analysis, such as sequencing joint sequences, deviation of library establishment length, sequencing errors, low-quality bases, undetected bases (represented by N) and the like, and the invalid data needs to be filtered through some means to ensure the normal operation of analysis. The filtering criteria are mainly as follows:
1) Removing the low quality region;
2) Removing the sequencing adapter sequence;
3) The data low quality region was filtered using Smrtlink software developed officially by Pacbio corporation to generate high quality consensus sequences. And then performing barcode splitting on the data to obtain single sample sequencing data for further analysis.
2.2 deduplication and alignment
The analysis software was used to remove the PCR-induced duplicates in the split data, and the high quality data after de-duplication was aligned to the human whole genome reference sequence (hg 38), with unique alignment (i.e., a single sequence could be aligned to only one position of the genome). And counting the sequence number of the target area, and evaluating the capturing efficiency, the coverage depth of the target area and the coverage integrity. The qualification criteria are: not less than 50 times the sequencing coverage of the target region, 30 times the coverage is required to be not less than 95%
2.3 mutation detection
And filtering reproductive variation information in the blood sample by using software for samples with the standard sequencing data quantity and quality, filtering out genetic variation (SNVs and SVs) only belonging to breast cancer tissues, screening out pathogenic variation, and performing variation map drawing to visualize the variation information.
Example 3 clinical sample detection
The method comprises the steps of carrying out breast cancer gene detection on blood and breast cancer tissues of 48 cases confirmed to be breast cancer through clinical diagnosis, and screening out unique variation information of the breast cancer tissues by filtering and comparing reproduction variation information in the blood. The data indicate that 48 samples all have Structural Variation (SVs) of breast cancer related genes, and the specific results are as follows:
structural variation Heat map of 48 samples on different genes (FIG. 1)
TABLE 1 Gene structural variation information detected in partial samples
Part of SV variation patterns are shown in figures 2-11, and part of SNV variation patterns are shown in figures 12-15;
example 4 clinical sample detection
In addition, 29 samples were taken and subjected to full-length transcriptome sequencing by using a Oxford Nanopore Technology platform, wherein the full-length transcriptome is a gene functional expression product, and if the transcriptome sequences have variation or fusion, the occurrence of gene variation can be proved.
The full-length transcriptome sequencing result shows that two reads exist in the data and are simultaneously compared with chr17:75,651,186-75,667,183 and chr8:36,231,091-36231235, and the result is shown as figure 16, and the result shows that two full-length transcriptome sequences support, and the RECQL5 gene on chr17 is fused with and transcriptionally expressed by the chr8 gene.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (9)
1. A breast cancer diagnostic probe set comprising probes targeting at least one of the following markers:
ERBB4, RAD51B, ESR1, NF1, FANCC, EGFR, BRIP1, ATM, WRN, ESR2, PGR, BLM, CDH1, MRE11, PIK3CA, RAD50, BRCA2, BARD1, BRCA1, CHEK2, NBS1, RAD51C, ERBB2, RECQL5, PALB2, ERBB3, RAD51D, and RECQL4.
2. The set of breast cancer diagnostic probes according to claim 1, wherein the probes are 50-130 bp in length designed with reference to human reference genome version Hg 38.
3. The set of breast cancer diagnostic probes according to claim 1, wherein each probe is spaced apart by an average of 500bp:
the detection probe of the ATM gene targets the space between chr11:108222232 and chr11: 108369359;
the detection probe of the BARD1 gene targets the space between 214725368 and 214809988 of chr2;
the detection probe of the BLM gene targets the range of chr15: 90717185-chr 15: 90816306;
the detection probe of the BRCA1 gene targets the range of chr17: 43044252-chr 17: 43170329;
the detection probe of the BRCA2 gene targets the range of chr13: 32314848-chr13: 32400373;
the detection probe of the BRIP1 gene targets the range of chr17: 61679001-chr 17: 61864121;
the detection probe of the CDH1 gene targets the space between chr16:68737106 and chr16: 68835226;
the detection probe of the CHEK2 gene targets the chr22: 28688022-chr22: 28742642;
the EGFR gene detection probe targets the chr7: 55018762-chr7: 55211883;
the detection probes of the ERBB2 gene target the chr17: 39687609-chr 17: 39730729;
the detection probe of the ERBB3 gene targets the range of chr12: 56078013-chr 12: 56103712;
the detection probe of the ERBB4 gene targets the range of chr2: 211375625-chr2: 212539246;
the detection probe of the ESR1 gene targets the space between chr6:151656594 and chr6: 152129714;
the detection probe of the ESR2 gene targets the range of chr14: 64084565-chr 14: 64338700;
the detection probes of the FANCC genes target the range of chr9: 95098855-chr9: 95426984;
the detection probe of the MRE11 gene targets the range of chr11: 94415321-chr11: 94512441;
the detection probes of the NBS1 genes target the chr8: 89933302-chr8: 90003341;
the detection probe of the NF1 gene targets the range of chr17: 31007684-chr 17: 31382286;
the detection probe of the PALB2 gene targets the space between chr16:23602948 and chr16: 23641568;
the detection probes of the PGR genes target the range of chr11: 101029335-chr11: 101130955;
the detection probe of the PIK3CA gene targets the chr3: 179148043-chr3: 179240163;
the detection probe of the RAD50 gene targets the range of chr5: 132555873-chr5: 132645514;
the detection probe of the RAD51B gene targets the range of chr14: 67819688-chr14: 68730308;
the detection probe of the RAD51C gene targets the range of chr17: 58692263-chr17: 58734994;
the detection probe of the RAD51D gene targets the range of chr17: 35092054-chr17: 35121674;
the detection probe of the RECQL4 gene targets the range of chr8: 144511004-chr8: 144518123;
the detection probe of the RECQL5 gene targets the range of chr17: 75626707-chr17: 75667327;
the detection probes of the WRN genes target the range of chr8: 31033028-chr8: 31175648.
4. The breast cancer diagnostic probe set of claim 1, wherein the detection probe sequence of each gene is:
ATM：
chr11:108222232-108222352,chr11:108222732-108222852,chr11:108223232-108223352,chr11:108223732-108223852,chr11:108224267-108224387,chr11:108225238-108225358,chr11:108226333-108226453,chr11:108227288-108227408,chr11:108227732-108227852,chr11:108228232-108228352,chr11:108228732-108228852,chr11:108229232-108229352,chr11:108231276-108231396,chr11:108232232-108232352,chr11:108233188-108233308,chr11:108234232-108234352,chr11:108234831-108234951,chr11:108235732-108235852,chr11:108236162-108236282,chr11:108236732-108236852,chr11:108237232-108237352,chr11:108239779-108239899,chr11:108240732-108240852,chr11:108241232-108241352,chr11:108242284-108242404,chr11:108242732-108242852,chr11:108243233-108243353,chr11:108243732-108243852,chr11:108244232-108244352,chr11:108244732-108244852,chr11:108245232-108245352,chr11:108245724-108245844,chr11:108246177-108246297,chr11:108246847-108246967,chr11:108248232-108248352,chr11:108249232-108249352,chr11:108249732-108249852,chr11:108250732-108250852,chr11:108251211-108251331,chr11:108251732-108251852,chr11:108252232-108252352,chr11:108252732-108252852,chr11:108253232-108253352,chr11:108253732-108253852,chr11:108254232-108254352,chr11:108255232-108255352,chr11:108255732-108255852,chr11:108256232-108256352,chr11:108257232-108257352,chr11:108257754-108257874,chr11:108258232-108258352,chr11:108258732-108258852,chr11:108259732-108259852,chr11:108266742-108266862,chr11:108267232-108267352,chr11:108267853-108267973,chr11:108268732-108268852,chr11:108269732-108269852,chr11:108270232-108270352,chr11:108271232-108271352,chr11:108271732-108271852,chr11:108272232-108272352,chr11:108272732-108272852,chr11:108273232-108273352,chr11:108278232-108278352,chr11:108279232-108279352,chr11:108279732-108279852,chr11:108280232-108280352,chr11:108280652-108280772,chr11:108281232-108281352,chr11:108281732-108281852,chr11:108282232-108282352,chr11:108282732-108282852,chr11:108283232-108283352,chr11:108284232-108284352,chr11:108284732-108284852,chr11:108285239-108285359,chr11:108285732-108285852,chr11:108286819-108286939,chr11:108287280-108287400,chr11:108287732-108287852,chr11:108288732-108288852,chr11:108289232-108289352,chr11:108289732-108289852,chr11:108290188-108290308,chr11:108290822-108290942,chr11:108291732-108291852,chr11:108292232-108292352,chr11:108292732-108292852,chr11:108293232-108293352,chr11:108294232-108294352,chr11:108294733-108294853,chr11:108295232-108295352,chr11:108296154-108296274,chr11:108296627-108296747,chr11:108297232-108297352,chr11:108297732-108297852,chr11:108298232-108298352,chr11:108298732-108298852,chr11:108299232-108299352,chr11:108299732-108299852,chr11:108300232-108300352,chr11:108301232-108301352,chr11:108301732-108301852,chr11:108302232-108302352,chr11:108302732-108302852,chr11:108303732-108303852,chr11:108304232-108304352,chr11:108304732-108304852,chr11:108305200-108305320,chr11:108305732-108305852,chr11:108306353-108306473,chr11:108307689-108307809,chr11:108308232-108308352,chr11:108308732-108308852,chr11:108309232-108309352,chr11:108309732-108309852,chr11:108310232-108310352,chr11:108310732-108310852,chr11:108311254-108311374,chr11:108311733-108311853,chr11:108312232-108312352,chr11:108313189-108313309,chr11:108315732-108315852,chr11:108316232-108316352,chr11:108317232-108317352,chr11:108317733-108317853,chr11:108318732-108318852,chr11:108319172-108319292,chr11:108319732-108319852,chr11:108320232-108320352,chr11:108321232-108321352,chr11:108321780-108321900,chr11:108322732-108322852,chr11:108323232-108323352,chr11:108323732-108323852,chr11:108324732-108324852,chr11:108325232-108325352,chr11:108326232-108326352,chr11:108326724-108326844,chr11:108327171-108327291,chr11:108327732-108327852,chr11:108329232-108329352,chr11:108329732-108329852,chr11:108330232-108330352,chr11:108330732-108330852,chr11:108331232-108331352,chr11:108331732-108331852,chr11:108332732-108332852,chr11:108333232-108333352,chr11:108333732-108333852,chr11:108334232-108334352,chr11:108334732-108334852,chr11:108335232-108335352,chr11:108335732-108335852,chr11:108336308-108336428,chr11:108336763-108336883,chr11:108337232-108337352,chr11:108337732-108337852,chr11:108338729-108338849,chr11:108339203-108339323,chr11:108339732-108339852,chr11:108340232-108340352,chr11:108341232-108341352,chr11:108342200-108342320,chr11:108342732-108342852,chr11:108343232-108343352,chr11:108343795-108343915,chr11:108344232-108344352,chr11:108345243-108345363,chr11:108345732-108345852,chr11:108346232-108346352,chr11:108346732-108346852,chr11:108347232-108347352,chr11:108347732-108347852,chr11:108348232-108348352,chr11:108348732-108348852,chr11:108349232-108349352,chr11:108349732-108349852,chr11:108350232-108350352,chr11:108350732-108350852,chr11:108351190-108351310,chr11:108351760-108351880,chr11:108352232-108352352,chr11:108353732-108353852,chr11:108354232-108354352,chr11:108354732-108354852,chr11:108355232-108355352,chr11:108355732-108355852,chr11:108356156-108356276,chr11:108356683-108356803,chr11:108363238-108363358,chr11:108363732-108363852,chr11:108364232-108364352,chr11:108364732-108364852,chr11:108365232-108365352,chr11:108366232-108366352,chr11:108367732-108367852,chr11:108368285-108368405,chr11:108368740-108368860,chr11:108369239-108369359；
BARD1：
chr2:214725368-214725488,chr2:214725868-214725988,chr2:214726368-214726488,chr2:214726868-214726988,chr2:214727368-214727488,chr2:214727868-214727988,chr2:214728368-214728488,chr2:214728868-214728988,chr2:214729419-214729539,chr2:214729868-214729988,chr2:214730368-214730488,chr2:214730868-214730988,chr2:214731368-214731488,chr2:214731868-214731988,chr2:214732299-214732419,chr2:214732868-214732988,chr2:214733868-214733988,chr2:214734368-214734488,chr2:214735868-214735988,chr2:214736368-214736488,chr2:214736868-214736988,chr2:214737368-214737488,chr2:214737868-214737988,chr2:214738368-214738488,chr2:214739368-214739488,chr2:214739868-214739988,chr2:214740368-214740488,chr2:214740868-214740988,chr2:214741369-214741489,chr2:214741868-214741988,chr2:214742368-214742488,chr2:214742868-214742988,chr2:214743319-214743439,chr2:214743934-214744054,chr2:214744368-214744488,chr2:214744910-214745030,chr2:214745368-214745488,chr2:214745868-214745988,chr2:214746368-214746488,chr2:214747869-214747989,chr2:214748368-214748488,chr2:214749368-214749488,chr2:214749868-214749988,chr2:214751442-214751562,chr2:214752369-214752489,chr2:214752868-214752988,chr2:214753368-214753488,chr2:214753874-214753994,chr2:214754369-214754489,chr2:214754868-214754988,chr2:214755391-214755511,chr2:214755868-214755988,chr2:214757368-214757488,chr2:214757868-214757988,chr2:214758368-214758488,chr2:214758868-214758988,chr2:214759368-214759488,chr2:214759868-214759988,chr2:214760472-214760592,chr2:214761404-214761524,chr2:214761868-214761988,chr2:214762369-214762489,chr2:214762954-214763074,chr2:214763868-214763988,chr2:214764345-214764465,chr2:214764868-214764988,chr2:214765302-214765422,chr2:214765868-214765988,chr2:214766368-214766488,chr2:214767368-214767488,chr2:214767868-214767988,chr2:214768368-214768488,chr2:214768868-214768988,chr2:214769362-214769482,chr2:214769868-214769988,chr2:214770368-214770488,chr2:214770868-214770988,chr2:214771350-214771470,chr2:214771923-214772043,chr2:214772368-214772488,chr2:214772868-214772988,chr2:214773322-214773442,chr2:214775868-214775988,chr2:214776368-214776488,chr2:214776868-214776988,chr2:214777368-214777488,chr2:214777819-214777939,chr2:214778368-214778488,chr2:214778868-214778988,chr2:214779480-214779600,chr2:214780368-214780488,chr2:214780868-214780988,chr2:214781368-214781488,chr2:214781868-214781988,chr2:214782868-214782988,chr2:214785329-214785449,chr2:214785816-214785936,chr2:214786368-214786488,chr2:214786868-214786988,chr2:214787368-214787488,chr2:214787868-214787988,chr2:214788368-214788488,chr2:214788868-214788988,chr2:214789868-214789988,chr2:214790368-214790488,chr2:214790868-214790988,chr2:214791368-214791488,chr2:214792368-214792488,chr2:214792868-214792988,chr2:214793388-214793508,chr2:214794368-214794488,chr2:214795368-214795488,chr2:214795868-214795988,chr2:214796368-214796488,chr2:214796968-214797088,chr2:214797868-214797988,chr2:214798368-214798488,chr2:214799368-214799488,chr2:214799868-214799988,chr2:214800305-214800425,chr2:214800907-214801027,chr2:214801368-214801488,chr2:214802474-214802594,chr2:214804368-214804488,chr2:214805368-214805488,chr2:214805868-214805988,chr2:214806390-214806510,chr2:214806872-214806992,chr2:214807368-214807488,chr2:214807868-214807988,chr2:214808410-214808530,chr2:214808868-214808988,chr2:214809368-214809488,chr2:214809868-214809988；
BLM：
chr15:90717185-90717305,chr15:90717685-90717805,chr15:90718685-90718805,chr15:90719743-90719863,chr15:90720263-90720383,chr15:90721185-90721305,chr15:90722631-90722751,chr15:90723188-90723308,chr15:90724268-90724388,chr15:90725228-90725348,chr15:90727293-90727413,chr15:90728722-90728842,chr15:90729682-90729802,chr15:90730162-90730282,chr15:90730762-90730882,chr15:90731242-90731362,chr15:90731722-90731842,chr15:90732202-90732322,chr15:90732682-90732802,chr15:90733162-90733282,chr15:90734697-90734817,chr15:90735177-90735297,chr15:90735729-90735849,chr15:90736167-90736287,chr15:90736685-90736805,chr15:90737239-90737359,chr15:90737685-90737805,chr15:90739671-90739791,chr15:90740185-90740305,chr15:90741305-90741425,chr15:90742185-90742305,chr15:90743258-90743378,chr15:90743686-90743806,chr15:90744185-90744305,chr15:90745085-90745205,chr15:90745685-90745805,chr15:90746267-90746387,chr15:90747186-90747306,chr15:90748186-90748306,chr15:90748656-90748776,chr15:90749186-90749306,chr15:90749686-90749806,chr15:90750186-90750306,chr15:90751186-90751306,chr15:90751686-90751806,chr15:90752686-90752806,chr15:90753686-90753806,chr15:90754186-90754306,chr15:90754686-90754806,chr15:90755187-90755307,chr15:90756725-90756845,chr15:90757186-90757306,chr15:90757686-90757806,chr15:90758686-90758806,chr15:90759182-90759302,chr15:90760186-90760306,chr15:90760686-90760806,chr15:90761186-90761306,chr15:90761661-90761781,chr15:90762162-90762282,chr15:90762687-90762807,chr15:90763186-90763306,chr15:90763697-90763817,chr15:90764133-90764253,chr15:90764686-90764806,chr15:90765186-90765306,chr15:90765686-90765806,chr15:90766186-90766306,chr15:90766707-90766827,chr15:90767186-90767306,chr15:90767686-90767806,chr15:90768617-90768737,chr15:90769186-90769306,chr15:90769793-90769913,chr15:90770686-90770806,chr15:90771108-90771228,chr15:90771694-90771814,chr15:90772186-90772306,chr15:90772686-90772806,chr15:90774186-90774306,chr15:90774804-90774924,chr15:90776186-90776306,chr15:90777570-90777690,chr15:90778186-90778306,chr15:90779298-90779418,chr15:90781164-90781284,chr15:90781768-90781888,chr15:90782744-90782864,chr15:90783186-90783306,chr15:90784686-90784806,chr15:90785170-90785290,chr15:90787570-90787690,chr15:90788592-90788712,chr15:90789186-90789306,chr15:90789686-90789806,chr15:90790186-90790306,chr15:90790686-90790806,chr15:90791186-90791306,chr15:90793769-90793889,chr15:90795098-90795218,chr15:90796236-90796356,chr15:90796686-90796806,chr15:90797686-90797806,chr15:90798186-90798306,chr15:90799187-90799307,chr15:90800249-90800369,chr15:90800686-90800806,chr15:90801187-90801307,chr15:90801678-90801798,chr15:90802186-90802306,chr15:90803187-90803307,chr15:90803686-90803806,chr15:90804186-90804306,chr15:90805140-90805260,chr15:90806686-90806806,chr15:90807185-90807305,chr15:90807665-90807785,chr15:90808186-90808306,chr15:90808766-90808886,chr15:90809186-90809306,chr15:90809686-90809806,chr15:90810686-90810806,chr15:90811186-90811306,chr15:90812186-90812306,chr15:90812686-90812806,chr15:90813186-90813306,chr15:90813686-90813806,chr15:90814186-90814306,chr15:90814686-90814806,chr15:90815186-90815306,chr15:90815629-90815749,chr15:90816186-90816306；
BRCA1：
chr17:43044252-43044372,chr17:43044690-43044810,chr17:43045209-43045329,chr17:43045709-43045829,chr17:43046753-43046873,chr17:43047645-43047765,chr17:43048797-43048917,chr17:43049709-43049829,chr17:43050209-43050329,chr17:43050709-43050829,chr17:43051209-43051329,chr17:43052683-43052803,chr17:43053209-43053329,chr17:43054209-43054329,chr17:43055209-43055329,chr17:43056102-43056222,chr17:43057130-43057250,chr17:43058709-43058829,chr17:43059742-43059862,chr17:43061125-43061245,chr17:43063209-43063329,chr17:43063709-43063829,chr17:43064209-43064329,chr17:43064709-43064829,chr17:43065209-43065329,chr17:43065741-43065861,chr17:43066210-43066330,chr17:43066710-43066830,chr17:43067141-43067261,chr17:43067666-43067786,chr17:43068709-43068829,chr17:43069209-43069329,chr17:43069709-43069829,chr17:43070212-43070332,chr17:43070709-43070829,chr17:43071209-43071329,chr17:43073209-43073329,chr17:43073640-43073760,chr17:43074209-43074329,chr17:43074675-43074795,chr17:43075209-43075329,chr17:43075709-43075829,chr17:43076209-43076329,chr17:43076709-43076829,chr17:43077209-43077329,chr17:43078709-43078829,chr17:43081209-43081329,chr17:43081709-43081829,chr17:43082209-43082329,chr17:43082709-43082829,chr17:43083709-43083829,chr17:43084709-43084829,chr17:43085160-43085280,chr17:43085709-43085829,chr17:43086209-43086329,chr17:43086709-43086829,chr17:43087237-43087357,chr17:43088709-43088829,chr17:43089313-43089433,chr17:43090255-43090375,chr17:43090709-43090829,chr17:43091209-43091329,chr17:43091709-43091829,chr17:43092209-43092329,chr17:43092709-43092829,chr17:43093209-43093329,chr17:43093709-43093829,chr17:43094209-43094329,chr17:43094709-43094829,chr17:43095202-43095322,chr17:43095709-43095829,chr17:43096709-43096829,chr17:43097209-43097329,chr17:43097826-43097946,chr17:43098277-43098397,chr17:43099162-43099282,chr17:43099709-43099829,chr17:43100209-43100329,chr17:43101094-43101214,chr17:43101781-43101901,chr17:43103049-43103169,chr17:43103709-43103829,chr17:43104209-43104329,chr17:43104710-43104830,chr17:43105137-43105257,chr17:43105598-43105718,chr17:43106209-43106329,chr17:43107791-43107911,chr17:43108329-43108449,chr17:43109276-43109396,chr17:43109701-43109821,chr17:43110142-43110262,chr17:43110594-43110714,chr17:43111154-43111274,chr17:43112702-43112822,chr17:43113209-43113329,chr17:43113704-43113824,chr17:43114211-43114331,chr17:43114709-43114829,chr17:43115709-43115829,chr17:43116714-43116834,chr17:43117746-43117866,chr17:43119265-43119385,chr17:43119709-43119829,chr17:43120209-43120329,chr17:43121742-43121862,chr17:43122209-43122329,chr17:43123215-43123335,chr17:43123709-43123829,chr17:43124209-43124329,chr17:43124653-43124773,chr17:43125209-43125329,chr17:43125709-43125829,chr17:43126209-43126329,chr17:43128709-43128829,chr17:43129209-43129329,chr17:43129752-43129872,chr17:43131209-43131329,chr17:43132209-43132329,chr17:43133209-43133329,chr17:43134209-43134329,chr17:43134709-43134829,chr17:43135209-43135329,chr17:43135709-43135829,chr17:43138210-43138330,chr17:43138709-43138829,chr17:43140787-43140907,chr17:43141210-43141330,chr17:43141782-43141902,chr17:43142207-43142327,chr17:43143220-43143340,chr17:43143709-43143829,chr17:43144217-43144337,chr17:43144641-43144761,chr17:43146709-43146829,chr17:43147709-43147829,chr17:43148714-43148834,chr17:43149652-43149772,chr17:43150709-43150829,chr17:43151205-43151325,chr17:43151709-43151829,chr17:43152184-43152304,chr17:43153042-43153162,chr17:43154709-43154829,chr17:43155802-43155922,chr17:43156238-43156358,chr17:43156709-43156829,chr17:43157209-43157329,chr17:43158209-43158329,chr17:43159839-43159959,chr17:43167780-43167900,chr17:43168209-43168329,chr17:43168709-43168829,chr17:43169709-43169829,chr17:43170209-43170329；
BRCA2：
chr13:32314848-32314968,chr13:32315753-32315873,chr13:32316271-32316391,chr13:32316698-32316818,chr13:32317174-32317294,chr13:32317753-32317873,chr13:32318254-32318374,chr13:32318754-32318874,chr13:32319237-32319357,chr13:32319724-32319844,chr13:32320245-32320365,chr13:32320745-32320865,chr13:32321753-32321873,chr13:32323753-32323873,chr13:32325253-32325373,chr13:32325819-32325939,chr13:32326253-32326373,chr13:32326753-32326873,chr13:32327670-32327790,chr13:32328782-32328902,chr13:32329253-32329373,chr13:32330253-32330373,chr13:32330842-32330962,chr13:32331701-32331821,chr13:32332253-32332373,chr13:32332753-32332873,chr13:32333253-32333373,chr13:32334254-32334374,chr13:32334753-32334873,chr13:32335343-32335463,chr13:32336253-32336373,chr13:32336753-32336873,chr13:32337253-32337373,chr13:32337753-32337873,chr13:32338253-32338373,chr13:32338753-32338873,chr13:32339253-32339373,chr13:32339753-32339873,chr13:32340253-32340373,chr13:32340753-32340873,chr13:32341253-32341373,chr13:32341860-32341980,chr13:32342336-32342456,chr13:32343253-32343373,chr13:32343753-32343873,chr13:32344253-32344373,chr13:32345311-32345431,chr13:32346253-32346373,chr13:32346753-32346873,chr13:32347253-32347373,chr13:32347753-32347873,chr13:32348253-32348373,chr13:32348731-32348851,chr13:32349211-32349331,chr13:32349811-32349931,chr13:32350291-32350411,chr13:32350771-32350891,chr13:32351699-32351819,chr13:32352253-32352373,chr13:32352753-32352873,chr13:32353709-32353829,chr13:32354253-32354373,chr13:32354753-32354873,chr13:32355253-32355373,chr13:32356349-32356469,chr13:32357268-32357388,chr13:32357753-32357873,chr13:32359254-32359374,chr13:32359735-32359855,chr13:32360188-32360308,chr13:32360753-32360873,chr13:32361253-32361373,chr13:32361843-32361963,chr13:32362308-32362428,chr13:32362753-32362873,chr13:32363253-32363373,chr13:32363753-32363873,chr13:32364753-32364873,chr13:32365281-32365401,chr13:32365726-32365846,chr13:32366253-32366373,chr13:32366806-32366926,chr13:32368701-32368821,chr13:32369253-32369373,chr13:32370253-32370373,chr13:32370872-32370992,chr13:32371619-32371739,chr13:32376142-32376262,chr13:32376753-32376873,chr13:32377212-32377332,chr13:32377753-32377873,chr13:32378253-32378373,chr13:32378741-32378861,chr13:32379253-32379373,chr13:32379753-32379873,chr13:32380253-32380373,chr13:32381253-32381373,chr13:32381760-32381880,chr13:32382240-32382360,chr13:32382753-32382873,chr13:32383320-32383440,chr13:32383753-32383873,chr13:32384253-32384373,chr13:32384753-32384873,chr13:32385253-32385373,chr13:32385753-32385873,chr13:32386743-32386863,chr13:32388646-32388766,chr13:32389169-32389289,chr13:32389753-32389873,chr13:32390212-32390332,chr13:32390753-32390873,chr13:32391753-32391873,chr13:32392253-32392373,chr13:32392753-32392873,chr13:32393253-32393373,chr13:32393746-32393866,chr13:32394253-32394373,chr13:32394753-32394873,chr13:32395253-32395373,chr13:32395753-32395873,chr13:32396275-32396395,chr13:32396753-32396873,chr13:32397253-32397373,chr13:32397796-32397916,chr13:32398253-32398373,chr13:32398753-32398873,chr13:32399253-32399373,chr13:32399687-32399807,chr13:32400253-32400373；
BRIP1：
chr17:61679001-61679121,chr17:61679501-61679621,chr17:61679963-61680083,chr17:61681527-61681647,chr17:61682001-61682121,chr17:61682501-61682621,chr17:61683121-61683241,chr17:61684001-61684121,chr17:61685268-61685388,chr17:61686001-61686121,chr17:61686501-61686621,chr17:61686996-61687116,chr17:61687501-61687621,chr17:61687948-61688068,chr17:61689501-61689621,chr17:61692501-61692621,chr17:61693501-61693621,chr17:61695501-61695621,chr17:61696979-61697099,chr17:61698501-61698621,chr17:61699499-61699619,chr17:61699979-61700099,chr17:61700501-61700621,chr17:61701001-61701121,chr17:61701501-61701621,chr17:61702001-61702121,chr17:61705499-61705619,chr17:61706459-61706579,chr17:61707001-61707121,chr17:61707501-61707621,chr17:61708019-61708139,chr17:61708492-61708612,chr17:61709001-61709121,chr17:61709501-61709621,chr17:61710001-61710121,chr17:61710514-61710634,chr17:61711489-61711609,chr17:61712016-61712136,chr17:61712502-61712622,chr17:61715501-61715621,chr17:61716001-61716121,chr17:61717501-61717621,chr17:61718001-61718121,chr17:61718501-61718621,chr17:61719090-61719210,chr17:61720410-61720530,chr17:61721121-61721241,chr17:61721548-61721668,chr17:61722501-61722621,chr17:61723001-61723121,chr17:61723501-61723621,chr17:61724002-61724122,chr17:61724501-61724621,chr17:61725001-61725121,chr17:61725501-61725621,chr17:61725997-61726117,chr17:61726501-61726621,chr17:61727001-61727121,chr17:61728108-61728228,chr17:61728919-61729039,chr17:61729556-61729676,chr17:61730001-61730121,chr17:61730501-61730621,chr17:61731001-61731121,chr17:61731910-61732030,chr17:61732432-61732552,chr17:61733002-61733122,chr17:61733501-61733621,chr17:61734053-61734173,chr17:61734501-61734621,chr17:61735001-61735121,chr17:61736501-61736621,chr17:61737001-61737121,chr17:61737564-61737684,chr17:61738001-61738121,chr17:61738501-61738621,chr17:61739001-61739121,chr17:61739501-61739621,chr17:61740001-61740121,chr17:61740471-61740591,chr17:61743001-61743121,chr17:61743501-61743621,chr17:61744001-61744121,chr17:61744501-61744621,chr17:61745001-61745121,chr17:61746001-61746121,chr17:61746501-61746621,chr17:61747001-61747121,chr17:61748501-61748621,chr17:61750501-61750621,chr17:61751557-61751677,chr17:61752501-61752621,chr17:61753001-61753121,chr17:61753477-61753597,chr17:61754001-61754121,chr17:61754437-61754557,chr17:61755559-61755679,chr17:61756001-61756121,chr17:61756501-61756621,chr17:61757001-61757121,chr17:61757501-61757621,chr17:61758003-61758123,chr17:61758480-61758600,chr17:61763501-61763621,chr17:61763929-61764049,chr17:61764496-61764616,chr17:61765001-61765121,chr17:61766001-61766121,chr17:61766501-61766621,chr17:61767001-61767121,chr17:61768001-61768121,chr17:61768501-61768621,chr17:61769001-61769121,chr17:61769501-61769621,chr17:61770001-61770121,chr17:61770501-61770621,chr17:61773001-61773121,chr17:61774613-61774733,chr17:61775501-61775621,chr17:61776501-61776621,chr17:61776982-61777102,chr17:61777501-61777621,chr17:61778501-61778621,chr17:61779001-61779121,chr17:61780001-61780121,chr17:61781001-61781121,chr17:61781501-61781621,chr17:61781970-61782090,chr17:61783001-61783121,chr17:61783562-61783682,chr17:61784066-61784186,chr17:61785001-61785121,chr17:61785501-61785621,chr17:61786001-61786121,chr17:61786474-61786594,chr17:61787527-61787647,chr17:61788007-61788127,chr17:61788487-61788607,chr17:61789483-61789603,chr17:61789960-61790080,chr17:61791001-61791121,chr17:61791531-61791651,chr17:61793501-61793621,chr17:61794001-61794121,chr17:61797001-61797121,chr17:61797538-61797658,chr17:61798001-61798121,chr17:61798502-61798622,chr17:61799001-61799121,chr17:61799501-61799621,chr17:61800001-61800121,chr17:61800501-61800621,chr17:61801001-61801121,chr17:61801501-61801621,chr17:61801958-61802078,chr17:61802502-61802622,chr17:61803611-61803731,chr17:61805086-61805206,chr17:61806001-61806121,chr17:61806501-61806621,chr17:61807001-61807121,chr17:61807501-61807621,chr17:61808001-61808121,chr17:61808501-61808621,chr17:61809001-61809121,chr17:61809501-61809621,chr17:61810001-61810121,chr17:61810501-61810621,chr17:61811001-61811121,chr17:61811502-61811622,chr17:61812001-61812121,chr17:61812501-61812621,chr17:61813001-61813121,chr17:61813501-61813621,chr17:61814001-61814121,chr17:61814501-61814621,chr17:61815001-61815121,chr17:61815501-61815621,chr17:61816001-61816121,chr17:61816501-61816621,chr17:61817461-61817581,chr17:61818501-61818621,chr17:61820014-61820134,chr17:61820465-61820585,chr17:61822008-61822128,chr17:61822501-61822621,chr17:61823001-61823121,chr17:61823501-61823621,chr17:61824091-61824211,chr17:61829001-61829121,chr17:61829501-61829621,chr17:61830501-61830621,chr17:61831001-61831121,chr17:61832001-61832121,chr17:61832501-61832621,chr17:61833001-61833121,chr17:61833501-61833621,chr17:61834092-61834212,chr17:61835001-61835121,chr17:61835501-61835621,chr17:61836001-61836121,chr17:61836462-61836582,chr17:61837057-61837177,chr17:61837501-61837621,chr17:61838001-61838121,chr17:61838573-61838693,chr17:61839001-61839121,chr17:61839501-61839621,chr17:61839979-61840099,chr17:61841501-61841621,chr17:61842575-61842695,chr17:61843501-61843621,chr17:61844590-61844710,chr17:61845081-61845201,chr17:61847001-61847121,chr17:61847501-61847621,chr17:61848001-61848121,chr17:61848502-61848622,chr17:61849001-61849121,chr17:61849501-61849621,chr17:61850001-61850121,chr17:61851501-61851621,chr17:61852047-61852167,chr17:61853001-61853121,chr17:61853497-61853617,chr17:61855001-61855121,chr17:61856101-61856221,chr17:61857001-61857121,chr17:61858001-61858121,chr17:61859054-61859174,chr17:61860001-61860121,chr17:61861002-61861122,chr17:61861501-61861621,chr17:61862001-61862121,chr17:61862613-61862733,chr17:61863501-61863621,chr17:61864001-61864121；
CDH1：
chr16:68737106-68737226,chr16:68737606-68737726,chr16:68738106-68738226,chr16:68738586-68738706,chr16:68740106-68740226,chr16:68740606-68740726,chr16:68741106-68741226,chr16:68741589-68741709,chr16:68742106-68742226,chr16:68742700-68742820,chr16:68743645-68743765,chr16:68744106-68744226,chr16:68744550-68744670,chr16:68745106-68745226,chr16:68745616-68745736,chr16:68746568-68746688,chr16:68747038-68747158,chr16:68748711-68748831,chr16:68750106-68750226,chr16:68750606-68750726,chr16:68751106-68751226,chr16:68752606-68752726,chr16:68753212-68753332,chr16:68754607-68754727,chr16:68755606-68755726,chr16:68756106-68756226,chr16:68756606-68756726,chr16:68757531-68757651,chr16:68758099-68758219,chr16:68758607-68758727,chr16:68760606-68760726,chr16:68761106-68761226,chr16:68762496-68762616,chr16:68763106-68763226,chr16:68763606-68763726,chr16:68764106-68764226,chr16:68764607-68764727,chr16:68765089-68765209,chr16:68765606-68765726,chr16:68767092-68767212,chr16:68767658-68767778,chr16:68768225-68768345,chr16:68769196-68769316,chr16:68770164-68770284,chr16:68770606-68770726,chr16:68771106-68771226,chr16:68772106-68772226,chr16:68773066-68773186,chr16:68774606-68774726,chr16:68775131-68775251,chr16:68775606-68775726,chr16:68776648-68776768,chr16:68777106-68777226,chr16:68778606-68778726,chr16:68779106-68779226,chr16:68780106-68780226,chr16:68780619-68780739,chr16:68781106-68781226,chr16:68782106-68782226,chr16:68782607-68782727,chr16:68783571-68783691,chr16:68784221-68784341,chr16:68785095-68785215,chr16:68786073-68786193,chr16:68786606-68786726,chr16:68787106-68787226,chr16:68788107-68788227,chr16:68788607-68788727,chr16:68790106-68790226,chr16:68790606-68790726,chr16:68791106-68791226,chr16:68791706-68791826,chr16:68792606-68792726,chr16:68793106-68793226,chr16:68795106-68795226,chr16:68796162-68796282,chr16:68796606-68796726,chr16:68797683-68797803,chr16:68798107-68798227,chr16:68798606-68798726,chr16:68799180-68799300,chr16:68799606-68799726,chr16:68800175-68800295,chr16:68801012-68801132,chr16:68801606-68801726,chr16:68802181-68802301,chr16:68803106-68803226,chr16:68803674-68803794,chr16:68804606-68804726,chr16:68805038-68805158,chr16:68806429-68806549,chr16:68807106-68807226,chr16:68807694-68807814,chr16:68808606-68808726,chr16:68809106-68809226,chr16:68810106-68810226,chr16:68811606-68811726,chr16:68812106-68812226,chr16:68812644-68812764,chr16:68813211-68813331,chr16:68814606-68814726,chr16:68815223-68815343,chr16:68817106-68817226,chr16:68817606-68817726,chr16:68819135-68819255,chr16:68820189-68820309,chr16:68820675-68820795,chr16:68821606-68821726,chr16:68822106-68822226,chr16:68822606-68822726,chr16:68823106-68823226,chr16:68823606-68823726,chr16:68824606-68824726,chr16:68825606-68825726,chr16:68826106-68826226,chr16:68826606-68826726,chr16:68827106-68827226,chr16:68827563-68827683,chr16:68828106-68828226,chr16:68828607-68828727,chr16:68829106-68829226,chr16:68829606-68829726,chr16:68830519-68830639,chr16:68833106-68833226,chr16:68833606-68833726,chr16:68834606-68834726,chr16:68835106-68835226；
CHEK2：
chr22:28688022-28688142,chr22:28689022-28689142,chr22:28689522-28689642,chr22:28690022-28690142,chr22:28691022-28691142,chr22:28692022-28692142,chr22:28692522-28692642,chr22:28693069-28693189,chr22:28693522-28693642,chr22:28694022-28694142,chr22:28694522-28694642,chr22:28695022-28695142,chr22:28695627-28695747,chr22:28696638-28696758,chr22:28697459-28697579,chr22:28697929-28698049,chr22:28698522-28698642,chr22:28699641-28699761,chr22:28700494-28700614,chr22:28701067-28701187,chr22:28701522-28701642,chr22:28703522-28703642,chr22:28704022-28704142,chr22:28704610-28704730,chr22:28705500-28705620,chr22:28707022-28707142,chr22:28707522-28707642,chr22:28708114-28708234,chr22:28709022-28709142,chr22:28709510-28709630,chr22:28710022-28710142,chr22:28710522-28710642,chr22:28711022-28711142,chr22:28711603-28711723,chr22:28712522-28712642,chr22:28714522-28714642,chr22:28716522-28716642,chr22:28718072-28718192,chr22:28719022-28719142,chr22:28719522-28719642,chr22:28719984-28720104,chr22:28720522-28720642,chr22:28721022-28721142,chr22:28721558-28721678,chr22:28722037-28722157,chr22:28722549-28722669,chr22:28723022-28723142,chr22:28723526-28723646,chr22:28724023-28724143,chr22:28724472-28724592,chr22:28725022-28725142,chr22:28725481-28725601,chr22:28726626-28726746,chr22:28727468-28727588,chr22:28728068-28728188,chr22:28729028-28729148,chr22:28730541-28730661,chr22:28731578-28731698,chr22:28732526-28732646,chr22:28733070-28733190,chr22:28733952-28734072,chr22:28734522-28734642,chr22:28735022-28735142,chr22:28735934-28736054,chr22:28736522-28736642,chr22:28737017-28737137,chr22:28738523-28738643,chr22:28741522-28741642,chr22:28742022-28742142,chr22:28742522-28742642；
EGFR：
chr7:55018762-55018882,chr7:55019262-55019382,chr7:55019762-55019882,chr7:55020262-55020382,chr7:55020744-55020864,chr7:55021262-55021382,chr7:55021689-55021809,chr7:55022262-55022382,chr7:55022762-55022882,chr7:55023262-55023382,chr7:55023762-55023882,chr7:55024262-55024382,chr7:55024762-55024882,chr7:55025262-55025382,chr7:55025762-55025882,chr7:55026251-55026371,chr7:55027262-55027382,chr7:55027762-55027882,chr7:55028262-55028382,chr7:55028762-55028882,chr7:55029262-55029382,chr7:55029762-55029882,chr7:55030262-55030382,chr7:55030762-55030882,chr7:55031262-55031382,chr7:55031762-55031882,chr7:55032262-55032382,chr7:55032762-55032882,chr7:55033262-55033382,chr7:55033762-55033882,chr7:55034762-55034882,chr7:55035262-55035382,chr7:55035696-55035816,chr7:55036279-55036399,chr7:55036762-55036882,chr7:55037262-55037382,chr7:55037800-55037920,chr7:55038263-55038383,chr7:55038849-55038969,chr7:55039762-55039882,chr7:55040262-55040382,chr7:55040762-55040882,chr7:55041762-55041882,chr7:55042262-55042382,chr7:55042762-55042882,chr7:55043762-55043882,chr7:55044262-55044382,chr7:55044811-55044931,chr7:55045262-55045382,chr7:55046262-55046382,chr7:55046841-55046961,chr7:55047262-55047382,chr7:55047763-55047883,chr7:55048262-55048382,chr7:55048762-55048882,chr7:55049262-55049382,chr7:55049762-55049882,chr7:55050762-55050882,chr7:55052262-55052382,chr7:55052762-55052882,chr7:55053262-55053382,chr7:55053762-55053882,chr7:55054262-55054382,chr7:55054762-55054882,chr7:55055363-55055483,chr7:55056262-55056382,chr7:55057286-55057406,chr7:55057762-55057882,chr7:55058831-55058951,chr7:55059762-55059882,chr7:55060262-55060382,chr7:55060762-55060882,chr7:55061262-55061382,chr7:55061762-55061882,chr7:55062262-55062382,chr7:55062762-55062882,chr7:55063262-55063382,chr7:55063762-55063882,chr7:55064262-55064382,chr7:55064762-55064882,chr7:55065262-55065382,chr7:55065762-55065882,chr7:55066262-55066382,chr7:55066762-55066882,chr7:55067262-55067382,chr7:55068262-55068382,chr7:55068762-55068882,chr7:55069262-55069382,chr7:55069762-55069882,chr7:55070262-55070382,chr7:55070762-55070882,chr7:55071262-55071382,chr7:55071762-55071882,chr7:55072235-55072355,chr7:55072762-55072882,chr7:55073356-55073476,chr7:55074262-55074382,chr7:55074762-55074882,chr7:55075262-55075382,chr7:55075762-55075882,chr7:55076262-55076382,chr7:55076762-55076882,chr7:55077262-55077382,chr7:55077762-55077882,chr7:55078262-55078382,chr7:55078762-55078882,chr7:55079262-55079382,chr7:55079762-55079882,chr7:55080234-55080354,chr7:55080813-55080933,chr7:55081262-55081382,chr7:55081762-55081882,chr7:55082262-55082382,chr7:55083262-55083382,chr7:55083762-55083882,chr7:55084262-55084382,chr7:55084782-55084902,chr7:55085262-55085382,chr7:55085762-55085882,chr7:55086263-55086383,chr7:55086762-55086882,chr7:55087260-55087380,chr7:55087762-55087882,chr7:55088262-55088382,chr7:55088762-55088882,chr7:55089262-55089382,chr7:55089762-55089882,chr7:55090262-55090382,chr7:55090762-55090882,chr7:55091262-55091382,chr7:55091750-55091870,chr7:55092262-55092382,chr7:55092762-55092882,chr7:55093262-55093382,chr7:55093762-55093882,chr7:55094262-55094382,chr7:55094762-55094882,chr7:55095323-55095443,chr7:55096262-55096382,chr7:55096762-55096882,chr7:55097262-55097382,chr7:55097762-55097882,chr7:55098262-55098382,chr7:55098762-55098882,chr7:55099262-55099382,chr7:55099762-55099882,chr7:55100262-55100382,chr7:55100736-55100856,chr7:55101262-55101382,chr7:55101860-55101980,chr7:55102762-55102882,chr7:55103262-55103382,chr7:55103762-55103882,chr7:55104262-55104382,chr7:55104762-55104882,chr7:55105262-55105382,chr7:55105762-55105882,chr7:55106262-55106382,chr7:55106762-55106882,chr7:55107262-55107382,chr7:55107762-55107882,chr7:55108262-55108382,chr7:55109262-55109382,chr7:55109762-55109882,chr7:55110262-55110382,chr7:55110762-55110882,chr7:55111262-55111382,chr7:55111762-55111882,chr7:55112262-55112382,chr7:55112845-55112965,chr7:55113762-55113882,chr7:55114762-55114882,chr7:55115262-55115382,chr7:55115762-55115882,chr7:55116262-55116382,chr7:55116762-55116882,chr7:55117262-55117382,chr7:55117762-55117882,chr7:55118357-55118477,chr7:55119262-55119382,chr7:55119756-55119876,chr7:55120262-55120382,chr7:55120762-55120882,chr7:55121262-55121382,chr7:55121762-55121882,chr7:55122262-55122382,chr7:55122762-55122882,chr7:55123262-55123382,chr7:55123730-55123850,chr7:55124262-55124382,chr7:55124762-55124882,chr7:55125262-55125382,chr7:55125841-55125961,chr7:55126762-55126882,chr7:55127262-55127382,chr7:55127762-55127882,chr7:55128262-55128382,chr7:55128762-55128882,chr7:55129225-55129345,chr7:55129653-55129773,chr7:55130262-55130382,chr7:55130762-55130882,chr7:55131262-55131382,chr7:55131762-55131882,chr7:55132262-55132382,chr7:55132762-55132882,chr7:55133262-55133382,chr7:55133762-55133882,chr7:55134262-55134382,chr7:55134737-55134857,chr7:55135262-55135382,chr7:55135762-55135882,chr7:55136262-55136382,chr7:55137262-55137382,chr7:55137762-55137882,chr7:55138262-55138382,chr7:55139276-55139396,chr7:55139762-55139882,chr7:55140262-55140382,chr7:55140762-55140882,chr7:55141262-55141382,chr7:55141762-55141882,chr7:55142262-55142382,chr7:55142796-55142916,chr7:55143262-55143382,chr7:55143762-55143882,chr7:55144306-55144426,chr7:55145262-55145382,chr7:55145714-55145834,chr7:55146221-55146341,chr7:55146762-55146882,chr7:55147262-55147382,chr7:55147762-55147882,chr7:55148262-55148382,chr7:55148762-55148882,chr7:55149234-55149354,chr7:55149857-55149977,chr7:55150762-55150882,chr7:55151262-55151382,chr7:55151881-55152001,chr7:55152700-55152820,chr7:55153262-55153382,chr7:55153762-55153882,chr7:55154262-55154382,chr7:55154762-55154882,chr7:55155762-55155882,chr7:55156262-55156382,chr7:55156762-55156882,chr7:55157323-55157443,chr7:55158262-55158382,chr7:55158762-55158882,chr7:55159262-55159382,chr7:55159768-55159888,chr7:55160262-55160382,chr7:55161262-55161382,chr7:55161762-55161882,chr7:55162262-55162382,chr7:55162696-55162816,chr7:55163262-55163382,chr7:55163762-55163882,chr7:55164262-55164382,chr7:55164762-55164882,chr7:55165262-55165382,chr7:55165762-55165882,chr7:55166259-55166379,chr7:55166762-55166882,chr7:55167743-55167863,chr7:55168262-55168382,chr7:55168762-55168882,chr7:55169762-55169882,chr7:55170262-55170382,chr7:55170762-55170882,chr7:55171262-55171382,chr7:55171762-55171882,chr7:55172262-55172382,chr7:55172762-55172882,chr7:55173262-55173382,chr7:55173762-55173882,chr7:55174262-55174382,chr7:55174762-55174882,chr7:55175262-55175382,chr7:55175762-55175882,chr7:55176262-55176382,chr7:55177262-55177382,chr7:55177762-55177882,chr7:55178262-55178382,chr7:55178762-55178882,chr7:55179362-55179482,chr7:55180262-55180382,chr7:55180762-55180882,chr7:55181262-55181382,chr7:55181762-55181882,chr7:55182262-55182382,chr7:55182762-55182882,chr7:55183762-55183882,chr7:55184262-55184382,chr7:55184762-55184882,chr7:55185262-55185382,chr7:55185762-55185882,chr7:55186262-55186382,chr7:55186762-55186882,chr7:55187241-55187361,chr7:55187762-55187882,chr7:55188262-55188382,chr7:55188762-55188882,chr7:55189262-55189382,chr7:55189821-55189941,chr7:55190262-55190382,chr7:55190762-55190882,chr7:55191262-55191382,chr7:55191762-55191882,chr7:55192262-55192382,chr7:55192762-55192882,chr7:55193262-55193382,chr7:55193762-55193882,chr7:55194762-55194882,chr7:55195262-55195382,chr7:55198262-55198382,chr7:55198762-55198882,chr7:55199262-55199382,chr7:55199762-55199882,chr7:55200262-55200382,chr7:55201262-55201382,chr7:55201762-55201882,chr7:55202305-55202425,chr7:55202762-55202882,chr7:55203788-55203908,chr7:55205262-55205382,chr7:55205762-55205882,chr7:55206262-55206382,chr7:55206762-55206882,chr7:55207262-55207382,chr7:55207762-55207882,chr7:55208262-55208382,chr7:55208762-55208882,chr7:55209262-55209382,chr7:55209762-55209882,chr7:55210262-55210382,chr7:55210762-55210882,chr7:55211262-55211382,chr7:55211763-55211883；
ERBB2：
chr17:39687609-39687729,chr17:39688109-39688229,chr17:39688610-39688730,chr17:39689109-39689229,chr17:39689990-39690110,chr17:39690609-39690729,chr17:39691034-39691154,chr17:39691602-39691722,chr17:39692202-39692322,chr17:39692682-39692802,chr17:39694609-39694729,chr17:39695109-39695229,chr17:39695607-39695727,chr17:39696109-39696229,chr17:39697109-39697229,chr17:39698160-39698280,chr17:39698609-39698729,chr17:39699080-39699200,chr17:39700109-39700229,chr17:39700609-39700729,chr17:39701107-39701227,chr17:39701609-39701729,chr17:39703109-39703229,chr17:39703609-39703729,chr17:39704158-39704278,chr17:39704609-39704729,chr17:39705157-39705277,chr17:39705609-39705729,chr17:39706109-39706229,chr17:39706609-39706729,chr17:39707109-39707229,chr17:39707601-39707721,chr17:39708219-39708339,chr17:39709109-39709229,chr17:39709609-39709729,chr17:39710109-39710229,chr17:39710549-39710669,chr17:39711526-39711646,chr17:39712109-39712229,chr17:39712603-39712723,chr17:39714109-39714229,chr17:39714617-39714737,chr17:39715109-39715229,chr17:39715609-39715729,chr17:39716109-39716229,chr17:39716609-39716729,chr17:39717109-39717229,chr17:39717609-39717729,chr17:39718110-39718230,chr17:39718648-39718768,chr17:39719552-39719672,chr17:39720058-39720178,chr17:39720553-39720673,chr17:39721577-39721697,chr17:39722648-39722768,chr17:39723109-39723229,chr17:39723609-39723729,chr17:39724609-39724729,chr17:39725109-39725229,chr17:39725609-39725729,chr17:39726609-39726729,chr17:39727109-39727229,chr17:39727609-39727729,chr17:39728109-39728229,chr17:39728609-39728729,chr17:39729109-39729229,chr17:39729609-39729729,chr17:39730109-39730229,chr17:39730609-39730729；
ERBB3：
chr12:56078013-56078133,chr12:56078687-56078807,chr12:56079592-56079712,chr12:56080092-56080212,chr12:56080592-56080712,chr12:56081119-56081239,chr12:56081592-56081712,chr12:56082092-56082212,chr12:56082592-56082712,chr12:56083092-56083212,chr12:56083592-56083712,chr12:56084092-56084212,chr12:56085092-56085212,chr12:56086093-56086213,chr12:56086592-56086712,chr12:56087134-56087254,chr12:56087592-56087712,chr12:56088092-56088212,chr12:56088592-56088712,chr12:56091618-56091738,chr12:56092687-56092807,chr12:56093592-56093712,chr12:56094092-56094212,chr12:56094572-56094692,chr12:56095092-56095212,chr12:56095592-56095712,chr12:56096183-56096303,chr12:56097092-56097212,chr12:56097673-56097793,chr12:56098592-56098712,chr12:56099593-56099713,chr12:56100092-56100212,chr12:56101092-56101212,chr12:56101592-56101712,chr12:56102092-56102212,chr12:56103092-56103212,chr12:56103592-56103712；
ERBB4：
chr2:211375625-211375745,chr2:211376125-211376245,chr2:211376625-211376745,chr2:211377125-211377245,chr2:211377625-211377745,chr2:211378125-211378245,chr2:211378625-211378745,chr2:211379125-211379245,chr2:211379625-211379745,chr2:211380125-211380245,chr2:211380625-211380745,chr2:211381125-211381245,chr2:211381625-211381745,chr2:211382125-211382245,chr2:211382625-211382745,chr2:211383125-211383245,chr2:211383625-211383745,chr2:211384125-211384245,chr2:211384625-211384745,chr2:211385125-211385245,chr2:211385625-211385745,chr2:211386125-211386245,chr2:211386702-211386822,chr2:211387125-211387245,chr2:211387625-211387745,chr2:211388125-211388245,chr2:211388625-211388745,chr2:211389125-211389245,chr2:211389593-211389713,chr2:211390091-211390211,chr2:211390625-211390745,chr2:211391125-211391245,chr2:211391625-211391745,chr2:211392125-211392245,chr2:211393125-211393245,chr2:211393625-211393745,chr2:211394125-211394245,chr2:211394625-211394745,chr2:211395125-211395245,chr2:211395625-211395745,chr2:211396192-211396312,chr2:211396625-211396745,chr2:211397125-211397245,chr2:211397625-211397745,chr2:211399125-211399245,chr2:211399625-211399745,chr2:211400070-211400190,chr2:211401125-211401245,chr2:211401625-211401745,chr2:211402625-211402745,chr2:211403127-211403247,chr2:211404125-211404245,chr2:211404625-211404745,chr2:211405172-211405292,chr2:211405625-211405745,chr2:211406612-211406732,chr2:211407125-211407245,chr2:211407625-211407745,chr2:211408125-211408245,chr2:211408625-211408745,chr2:211409125-211409245,chr2:211409625-211409745,chr2:211410125-211410245,chr2:211410625-211410745,chr2:211411186-211411306,chr2:211411625-211411745,chr2:211412125-211412245,chr2:211413619-211413739,chr2:211414625-211414745,chr2:211415625-211415745,chr2:211416125-211416245,chr2:211416625-211416745,chr2:211417097-211417217,chr2:211417625-211417745,chr2:211418125-211418245,chr2:211418625-211418745,chr2:211419061-211419181,chr2:211419625-211419745,chr2:211420125-211420245,chr2:211420625-211420745,chr2:211421125-211421245,chr2:211421625-211421745,chr2:211422125-211422245,chr2:211422625-211422745,chr2:211423125-211423245,chr2:211423625-211423745,chr2:211424125-211424245,chr2:211424625-211424745,chr2:211425125-211425245,chr2:211425592-211425712,chr2:211426138-211426258,chr2:211426625-211426745,chr2:211427125-211427245,chr2:211427625-211427745,chr2:211428223-211428343,chr2:211429125-211429245,chr2:211429625-211429745,chr2:211430125-211430245,chr2:211430625-211430745,chr2:211431125-211431245,chr2:211431625-211431745,chr2:211432125-211432245,chr2:211432625-211432745,chr2:211433125-211433245,chr2:211433625-211433745,chr2:211434125-211434245,chr2:211434625-211434745,chr2:211435125-211435245,chr2:211436125-211436245,chr2:211436625-211436745,chr2:211437125-211437245,chr2:211437625-211437745,chr2:211438214-211438334,chr2:211439125-211439245,chr2:211440125-211440245,chr2:211440625-211440745,chr2:211441125-211441245,chr2:211441625-211441745,chr2:211442724-211442844,chr2:211444099-211444219,chr2:211444625-211444745,chr2:211445125-211445245,chr2:211445625-211445745,chr2:211446125-211446245,chr2:211446625-211446745,chr2:211447125-211447245,chr2:211447625-211447745,chr2:211448625-211448745,chr2:211449125-211449245,chr2:211449625-211449745,chr2:211450159-211450279,chr2:211450639-211450759,chr2:211451625-211451745,chr2:211452089-211452209,chr2:211452625-211452745,chr2:211453125-211453245,chr2:211453625-211453745,chr2:211454125-211454245,chr2:211454625-211454745,chr2:211455125-211455245,chr2:211455625-211455745,chr2:211456055-211456175,chr2:211457125-211457245,chr2:211457625-211457745,chr2:211458626-211458746,chr2:211459125-211459245,chr2:211460125-211460245,chr2:211460625-211460745,chr2:211461125-211461245,chr2:211461625-211461745,chr2:211462625-211462745,chr2:211463125-211463245,chr2:211463625-211463745,chr2:211464125-211464245,chr2:211464625-211464745,chr2:211465625-211465745,chr2:211466125-211466245,chr2:211466625-211466745,chr2:211467125-211467245,chr2:211467625-211467745,chr2:211468125-211468245,chr2:211468625-211468745,chr2:211469125-211469245,chr2:211469625-211469745,chr2:211470125-211470245,chr2:211470562-211470682,chr2:211471040-211471160,chr2:211471543-211471663,chr2:211472125-211472245,chr2:211472625-211472745,chr2:211473125-211473245,chr2:211474625-211474745,chr2:211475125-211475245,chr2:211475625-211475745,chr2:211476125-211476245,chr2:211476625-211476745,chr2:211477651-211477771,chr2:211478125-211478245,chr2:211478625-211478745,chr2:211479229-211479349,chr2:211480125-211480245,chr2:211480635-211480755,chr2:211481125-211481245,chr2:211481625-211481745,chr2:211482125-211482245,chr2:211483125-211483245,chr2:211484125-211484245,chr2:211484625-211484745,chr2:211485125-211485245,chr2:211486125-211486245,chr2:211487625-211487745,chr2:211488125-211488245,chr2:211488625-211488745,chr2:211489125-211489245,chr2:211489625-211489745,chr2:211490125-211490245,chr2:211490625-211490745,chr2:211491125-211491245,chr2:211491625-211491745,chr2:211492125-211492245,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chr2:212385626-212385746,chr2:212386126-212386246,chr2:212386626-212386746,chr2:212387126-212387246,chr2:212387696-212387816,chr2:212388126-212388246,chr2:212388626-212388746,chr2:212389126-212389246,chr2:212389655-212389775,chr2:212390139-212390259,chr2:212390626-212390746,chr2:212391126-212391246,chr2:212392126-212392246,chr2:212392693-212392813,chr2:212393126-212393246,chr2:212393626-212393746,chr2:212394146-212394266,chr2:212394626-212394746,chr2:212395126-212395246,chr2:212396127-212396247,chr2:212396626-212396746,chr2:212397095-212397215,chr2:212397626-212397746,chr2:212398147-212398267,chr2:212398626-212398746,chr2:212399222-212399342,chr2:212400626-212400746,chr2:212401062-212401182,chr2:212401626-212401746,chr2:212402126-212402246,chr2:212402664-212402784,chr2:212403126-212403246,chr2:212403626-212403746,chr2:212404126-212404246,chr2:212405628-212405748,chr2:212406126-212406246,chr2:212406626-212406746,chr2:212407186-212407306,chr2:212407627-212407747,chr2:212409126-212409246,chr2:212409626-212409746,chr2:212410126-212410246,chr2:212410626-212410746,chr2:212411126-212411246,chr2:212411626-212411746,chr2:212412126-212412246,chr2:212412628-212412748,chr2:212413626-212413746,chr2:212414126-212414246,chr2:212414626-212414746,chr2:212415126-212415246,chr2:212415626-212415746,chr2:212416126-212416246,chr2:212416626-212416746,chr2:212417126-212417246,chr2:212417626-212417746,chr2:212418167-212418287,chr2:212418626-212418746,chr2:212419126-212419246,chr2:212419626-212419746,chr2:212420126-212420246,chr2:212420626-212420746,chr2:212421126-212421246,chr2:212421626-212421746,chr2:212422126-212422246,chr2:212422626-212422746,chr2:212423126-212423246,chr2:212423626-212423746,chr2:212424126-212424246,chr2:212424626-212424746,chr2:212425126-212425246,chr2:212425626-212425746,chr2:212426126-212426246,chr2:212427126-212427246,chr2:212427626-212427746,chr2:212428126-212428246,chr2:212428696-212428816,chr2:212429126-212429246,chr2:212430126-212430246,chr2:212430646-212430766,chr2:212431626-212431746,chr2:212432126-212432246,chr2:212432626-212432746,chr2:212433126-212433246,chr2:212433626-212433746,chr2:212434126-212434246,chr2:212434626-212434746,chr2:212435126-212435246,chr2:212435626-212435746,chr2:212436126-212436246,chr2:212436626-212436746,chr2:212437126-212437246,chr2:212437626-212437746,chr2:212438126-212438246,chr2:212438626-212438746,chr2:212439054-212439174,chr2:212439626-212439746,chr2:212447626-212447746,chr2:212448126-212448246,chr2:212448626-212448746,chr2:212449126-212449246,chr2:212449626-212449746,chr2:212450120-212450240,chr2:212450676-212450796,chr2:212451126-212451246,chr2:212451626-212451746,chr2:212452126-212452246,chr2:212452626-212452746,chr2:212453195-212453315,chr2:212453626-212453746,chr2:212454217-212454337,chr2:212455126-212455246,chr2:212455626-212455746,chr2:212456126-212456246,chr2:212456626-212456746,chr2:212457126-212457246,chr2:212457626-212457746,chr2:212458149-212458269,chr2:212458626-212458746,chr2:212459126-212459246,chr2:212459626-212459746,chr2:212463626-212463746,chr2:212464126-212464246,chr2:212464626-212464746,chr2:212465091-212465211,chr2:212465626-212465746,chr2:212466112-212466232,chr2:212468732-212468852,chr2:212469626-212469746,chr2:212470126-212470246,chr2:212470626-212470746,chr2:212471126-212471246,chr2:212471626-212471746,chr2:212472126-212472246,chr2:212473126-212473246,chr2:212473626-212473746,chr2:212474126-212474246,chr2:212474626-212474746,chr2:212475083-212475203,chr2:212475626-212475746,chr2:212476626-212476746,chr2:212477126-212477246,chr2:212477626-212477746,chr2:212478126-212478246,chr2:212478626-212478746,chr2:212479164-212479284,chr2:212479626-212479746,chr2:212480126-212480246,chr2:212480626-212480746,chr2:212481636-212481756,chr2:212482126-212482246,chr2:212483126-212483246,chr2:212483626-212483746,chr2:212484126-212484246,chr2:212484626-212484746,chr2:212485126-212485246,chr2:212485549-212485669,chr2:212486126-212486246,chr2:212486626-212486746,chr2:212487212-212487332,chr2:212488126-212488246,chr2:212488626-212488746,chr2:212489126-212489246,chr2:212489626-212489746,chr2:212490626-212490746,chr2:212491126-212491246,chr2:212491626-212491746,chr2:212492126-212492246,chr2:212492626-212492746,chr2:212493126-212493246,chr2:212493626-212493746,chr2:212494126-212494246,chr2:212495126-212495246,chr2:212495626-212495746,chr2:212496126-212496246,chr2:212496626-212496746,chr2:212497177-212497297,chr2:212497626-212497746,chr2:212498127-212498247,chr2:212498626-212498746,chr2:212499126-212499246,chr2:212499626-212499746,chr2:212500126-212500246,chr2:212500626-212500746,chr2:212501126-212501246,chr2:212501626-212501746,chr2:212502126-212502246,chr2:212502665-212502785,chr2:212503237-212503357,chr2:212504126-212504246,chr2:212504627-212504747,chr2:212505626-212505746,chr2:212508126-212508246,chr2:212508626-212508746,chr2:212509126-212509246,chr2:212509626-212509746,chr2:212510213-212510333,chr2:212511126-212511246,chr2:212511626-212511746,chr2:212512126-212512246,chr2:212512626-212512746,chr2:212513053-212513173,chr2:212514126-212514246,chr2:212515126-212515246,chr2:212515626-212515746,chr2:212516126-212516246,chr2:212516626-212516746,chr2:212517126-212517246,chr2:212517626-212517746,chr2:212518126-212518246,chr2:212518626-212518746,chr2:212519126-212519246,chr2:212520126-212520246,chr2:212520626-212520746,chr2:212521126-212521246,chr2:212522022-212522142,chr2:212522626-212522746,chr2:212523126-212523246,chr2:212523626-212523746,chr2:212524126-212524246,chr2:212524626-212524746,chr2:212525126-212525246,chr2:212525682-212525802,chr2:212526126-212526246,chr2:212526626-212526746,chr2:212527126-212527246,chr2:212527593-212527713,chr2:212528126-212528246,chr2:212528626-212528746,chr2:212529126-212529246,chr2:212529626-212529746,chr2:212530126-212530246,chr2:212530626-212530746,chr2:212531126-212531246,chr2:212531626-212531746,chr2:212532126-212532246,chr2:212532626-212532746,chr2:212533126-212533246,chr2:212533626-212533746,chr2:212534126-212534246,chr2:212534626-212534746,chr2:212535126-212535246,chr2:212535626-212535746,chr2:212536085-212536205,chr2:212536626-212536746,chr2:212537126-212537246,chr2:212537626-212537746,chr2:212538126-212538246,chr2:212539126-212539246；
ESR1：
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ESR2：
chr14:64084565-64084685,chr14:64086080-64086200,chr14:64086605-64086725,chr14:64087092-64087212,chr14:64087580-64087700,chr14:64088160-64088280,chr14:64088684-64088804,chr14:64089580-64089700,chr14:64090042-64090162,chr14:64090581-64090701,chr14:64091080-64091200,chr14:64091580-64091700,chr14:64092080-64092200,chr14:64092580-64092700,chr14:64093080-64093200,chr14:64093580-64093700,chr14:64094603-64094723,chr14:64095117-64095237,chr14:64096580-64096700,chr14:64097080-64097200,chr14:64097527-64097647,chr14:64098080-64098200,chr14:64098580-64098700,chr14:64099080-64099200,chr14:64099580-64099700,chr14:64101586-64101706,chr14:64102038-64102158,chr14:64103109-64103229,chr14:64103580-64103700,chr14:64104080-64104200,chr14:64105080-64105200,chr14:64105692-64105812,chr14:64106637-64106757,chr14:64107134-64107254,chr14:64107580-64107700,chr14:64108580-64108700,chr14:64109104-64109224,chr14:64109581-64109701,chr14:64110080-64110200,chr14:64110580-64110700,chr14:64112080-64112200,chr14:64112580-64112700,chr14:64113080-64113200,chr14:64113580-64113700,chr14:64114080-64114200,chr14:64114525-64114645,chr14:64115080-64115200,chr14:64116196-64116316,chr14:64116695-64116815,chr14:64118080-64118200,chr14:64119131-64119251,chr14:64119580-64119700,chr14:64120080-64120200,chr14:64121011-64121131,chr14:64121580-64121700,chr14:64122080-64122200,chr14:64123191-64123311,chr14:64124580-64124700,chr14:64125080-64125200,chr14:64125580-64125700,chr14:64126067-64126187,chr14:64126580-64126700,chr14:64128080-64128200,chr14:64128580-64128700,chr14:64129580-64129700,chr14:64130080-64130200,chr14:64131080-64131200,chr14:64132090-64132210,chr14:64132580-64132700,chr14:64133580-64133700,chr14:64134080-64134200,chr14:64134580-64134700,chr14:64135080-64135200,chr14:64135580-64135700,chr14:64136580-64136700,chr14:64137071-64137191,chr14:64137580-64137700,chr14:64138080-64138200,chr14:64138580-64138700,chr14:64139692-64139812,chr14:64140580-64140700,chr14:64141080-64141200,chr14:64141580-64141700,chr14:64142080-64142200,chr14:64142580-64142700,chr14:64143080-64143200,chr14:64143580-64143700,chr14:64144080-64144200,chr14:64144580-64144700,chr14:64145588-64145708,chr14:64146080-64146200,chr14:64146580-64146700,chr14:64147080-64147200,chr14:64147580-64147700,chr14:64148580-64148700,chr14:64149580-64149700,chr14:64150580-64150700,chr14:64151080-64151200,chr14:64151580-64151700,chr14:64152080-64152200,chr14:64152580-64152700,chr14:64153080-64153200,chr14:64153504-64153624,chr14:64155080-64155200,chr14:64155531-64155651,chr14:64156080-64156200,chr14:64156993-64157113,chr14:64158065-64158185,chr14:64158580-64158700,chr14:64159080-64159200,chr14:64159580-64159700,chr14:64160144-64160264,chr14:64160580-64160700,chr14:64161502-64161622,chr14:64162080-64162200,chr14:64162580-64162700,chr14:64163080-64163200,chr14:64163580-64163700,chr14:64164580-64164700,chr14:64165166-64165286,chr14:64166050-64166170,chr14:64166566-64166686,chr14:64167151-64167271,chr14:64167580-64167700,chr14:64168024-64168144,chr14:64168656-64168776,chr14:64169080-64169200,chr14:64169580-64169700,chr14:64170080-64170200,chr14:64170580-64170700,chr14:64171093-64171213,chr14:64171580-64171700,chr14:64172195-64172315,chr14:64173508-64173628,chr14:64173980-64174100,chr14:64174580-64174700,chr14:64175080-64175200,chr14:64175580-64175700,chr14:64176080-64176200,chr14:64176580-64176700,chr14:64177080-64177200,chr14:64177580-64177700,chr14:64178080-64178200,chr14:64179028-64179148,chr14:64179628-64179748,chr14:64180080-64180200,chr14:64181080-64181200,chr14:64181580-64181700,chr14:64182080-64182200,chr14:64184033-64184153,chr14:64184580-64184700,chr14:64186080-64186200,chr14:64186580-64186700,chr14:64187080-64187200,chr14:64187580-64187700,chr14:64188080-64188200,chr14:64188580-64188700,chr14:64189580-64189700,chr14:64190080-64190200,chr14:64190580-64190700,chr14:64191080-64191200,chr14:64191580-64191700,chr14:64192080-64192200,chr14:64193080-64193200,chr14:64193580-64193700,chr14:64194080-64194200,chr14:64194585-64194705,chr14:64195080-64195200,chr14:64195580-64195700,chr14:64196080-64196200,chr14:64196580-64196700,chr14:64197080-64197200,chr14:64197580-64197700,chr14:64198080-64198200,chr14:64198580-64198700,chr14:64199080-64199200,chr14:64200080-64200200,chr14:64200580-64200700,chr14:64201580-64201700,chr14:64202080-64202200,chr14:64202580-64202700,chr14:64203080-64203200,chr14:64203580-64203700,chr14:64204080-64204200,chr14:64204580-64204700,chr14:64205580-64205700,chr14:64206080-64206200,chr14:64206580-64206700,chr14:64207080-64207200,chr14:64207580-64207700,chr14:64208080-64208200,chr14:64208580-64208700,chr14:64209080-64209200,chr14:64209580-64209700,chr14:64210080-64210200,chr14:64210580-64210700,chr14:64211580-64211700,chr14:64212080-64212200,chr14:64212580-64212700,chr14:64213080-64213200,chr14:64213580-64213700,chr14:64214092-64214212,chr14:64214580-64214700,chr14:64215080-64215200,chr14:64215580-64215700,chr14:64216080-64216200,chr14:64216580-64216700,chr14:64217080-64217200,chr14:64217580-64217700,chr14:64218080-64218200,chr14:64218580-64218700,chr14:64219080-64219200,chr14:64219580-64219700,chr14:64220080-64220200,chr14:64220580-64220700,chr14:64221152-64221272,chr14:64221580-64221700,chr14:64222080-64222200,chr14:64223080-64223200,chr14:64223529-64223649,chr14:64223964-64224084,chr14:64224580-64224700,chr14:64225080-64225200,chr14:64225580-64225700,chr14:64226080-64226200,chr14:64226580-64226700,chr14:64227080-64227200,chr14:64227580-64227700,chr14:64228042-64228162,chr14:64228580-64228700,chr14:64229080-64229200,chr14:64229553-64229673,chr14:64230194-64230314,chr14:64231163-64231283,chr14:64232080-64232200,chr14:64232580-64232700,chr14:64233080-64233200,chr14:64234134-64234254,chr14:64234580-64234700,chr14:64235080-64235200,chr14:64235580-64235700,chr14:64236080-64236200,chr14:64236580-64236700,chr14:64237494-64237614,chr14:64238081-64238201,chr14:64238593-64238713,chr14:64239080-64239200,chr14:64239580-64239700,chr14:64240080-64240200,chr14:64241580-64241700,chr14:64242580-64242700,chr14:64243627-64243747,chr14:64244580-64244700,chr14:64245080-64245200,chr14:64245580-64245700,chr14:64247001-64247121,chr14:64247580-64247700,chr14:64248580-64248700,chr14:64249080-64249200,chr14:64249580-64249700,chr14:64250080-64250200,chr14:64250580-64250700,chr14:64251080-64251200,chr14:64251580-64251700,chr14:64253599-64253719,chr14:64254080-64254200,chr14:64255080-64255200,chr14:64256080-64256200,chr14:64257080-64257200,chr14:64257580-64257700,chr14:64258596-64258716,chr14:64259080-64259200,chr14:64259580-64259700,chr14:64260080-64260200,chr14:64260580-64260700,chr14:64261080-64261200,chr14:64262012-64262132,chr14:64262487-64262607,chr14:64263080-64263200,chr14:64263687-64263807,chr14:64265080-64265200,chr14:64265580-64265700,chr14:64266080-64266200,chr14:64267143-64267263,chr14:64268080-64268200,chr14:64269080-64269200,chr14:64269580-64269700,chr14:64270055-64270175,chr14:64271012-64271132,chr14:64276080-64276200,chr14:64276580-64276700,chr14:64277080-64277200,chr14:64277629-64277749,chr14:64278080-64278200,chr14:64278580-64278700,chr14:64279580-64279700,chr14:64280080-64280200,chr14:64280580-64280700,chr14:64281126-64281246,chr14:64281580-64281700,chr14:64282580-64282700,chr14:64283080-64283200,chr14:64284601-64284721,chr14:64285128-64285248,chr14:64286080-64286200,chr14:64286580-64286700,chr14:64287580-64287700,chr14:64288080-64288200,chr14:64288608-64288728,chr14:64289088-64289208,chr14:64289581-64289701,chr14:64290682-64290802,chr14:64291580-64291700,chr14:64292080-64292200,chr14:64292580-64292700,chr14:64293080-64293200,chr14:64293580-64293700,chr14:64294080-64294200,chr14:64294671-64294791,chr14:64295580-64295700,chr14:64296081-64296201,chr14:64296580-64296700,chr14:64297030-64297150,chr14:64297639-64297759,chr14:64298072-64298192,chr14:64298580-64298700,chr14:64299080-64299200,chr14:64299641-64299761,chr14:64301539-64301659,chr14:64302050-64302170,chr14:64302613-64302733,chr14:64303080-64303200,chr14:64303580-64303700,chr14:64305675-64305795,chr14:64306580-64306700,chr14:64308555-64308675,chr14:64309110-64309230,chr14:64309598-64309718,chr14:64311080-64311200,chr14:64312080-64312200,chr14:64313528-64313648,chr14:64319048-64319168,chr14:64321088-64321208,chr14:64321580-64321700,chr14:64322554-64322674,chr14:64323080-64323200,chr14:64323580-64323700,chr14:64324580-64324700,chr14:64325123-64325243,chr14:64326080-64326200,chr14:64326580-64326700,chr14:64327080-64327200,chr14:64327616-64327736,chr14:64328480-64328600,chr14:64329054-64329174,chr14:64329688-64329808,chr14:64331080-64331200,chr14:64332080-64332200,chr14:64333093-64333213,chr14:64334080-64334200,chr14:64335172-64335292,chr14:64335671-64335791,chr14:64336580-64336700,chr14:64337661-64337781,chr14:64338580-64338700；
FANCC：
chr9:95098855-95098975,chr9:95099364-95099484,chr9:95099898-95100018,chr9:95100364-95100484,chr9:95100909-95101029,chr9:95101364-95101484,chr9:95101864-95101984,chr9:95102364-95102484,chr9:95102864-95102984,chr9:95103354-95103474,chr9:95103864-95103984,chr9:95104364-95104484,chr9:95105864-95105984,chr9:95106904-95107024,chr9:95107364-95107484,chr9:95107864-95107984,chr9:95108364-95108484,chr9:95109430-95109550,chr9:95109864-95109984,chr9:95110364-95110484,chr9:95110864-95110984,chr9:95111364-95111484,chr9:95111864-95111984,chr9:95112364-95112484,chr9:95112864-95112984,chr9:95113364-95113484,chr9:95114364-95114484,chr9:95114859-95114979,chr9:95115364-95115484,chr9:95115864-95115984,chr9:95116364-95116484,chr9:95116864-95116984,chr9:95117364-95117484,chr9:95118331-95118451,chr9:95118864-95118984,chr9:95120329-95120449,chr9:95120809-95120929,chr9:95121287-95121407,chr9:95121767-95121887,chr9:95122364-95122484,chr9:95122864-95122984,chr9:95124364-95124484,chr9:95124864-95124984,chr9:95125364-95125484,chr9:95125864-95125984,chr9:95126364-95126484,chr9:95126864-95126984,chr9:95127864-95127984,chr9:95128364-95128484,chr9:95128812-95128932,chr9:95129364-95129484,chr9:95129864-95129984,chr9:95130365-95130485,chr9:95130864-95130984,chr9:95131364-95131484,chr9:95131864-95131984,chr9:95132364-95132484,chr9:95132864-95132984,chr9:95133364-95133484,chr9:95133864-95133984,chr9:95134364-95134484,chr9:95134864-95134984,chr9:95135364-95135484,chr9:95135800-95135920,chr9:95136374-95136494,chr9:95136864-95136984,chr9:95137364-95137484,chr9:95137864-95137984,chr9:95138364-95138484,chr9:95138864-95138984,chr9:95139364-95139484,chr9:95139864-95139984,chr9:95140364-95140484,chr9:95140864-95140984,chr9:95141364-95141484,chr9:95141864-95141984,chr9:95143364-95143484,chr9:95143864-95143984,chr9:95144364-95144484,chr9:95144864-95144984,chr9:95145364-95145484,chr9:95146753-95146873,chr9:95147864-95147984,chr9:95148364-95148484,chr9:95148864-95148984,chr9:95149864-95149984,chr9:95151351-95151471,chr9:95151917-95152037,chr9:95153864-95153984,chr9:95154318-95154438,chr9:95154827-95154947,chr9:95155365-95155485,chr9:95156364-95156484,chr9:95156864-95156984,chr9:95157364-95157484,chr9:95157864-95157984,chr9:95158364-95158484,chr9:95158864-95158984,chr9:95160945-95161065,chr9:95162864-95162984,chr9:95163364-95163484,chr9:95164364-95164484,chr9:95165864-95165984,chr9:95166364-95166484,chr9:95166809-95166929,chr9:95168265-95168385,chr9:95169864-95169984,chr9:95170364-95170484,chr9:95170864-95170984,chr9:95171364-95171484,chr9:95171864-95171984,chr9:95172364-95172484,chr9:95172864-95172984,chr9:95173364-95173484,chr9:95173890-95174010,chr9:95174423-95174543,chr9:95174864-95174984,chr9:95175364-95175484,chr9:95175864-95175984,chr9:95176364-95176484,chr9:95176864-95176984,chr9:95177864-95177984,chr9:95178364-95178484,chr9:95178864-95178984,chr9:95180339-95180459,chr9:95181364-95181484,chr9:95181864-95181984,chr9:95182876-95182996,chr9:95183364-95183484,chr9:95183864-95183984,chr9:95184364-95184484,chr9:95184864-95184984,chr9:95185364-95185484,chr9:95185864-95185984,chr9:95186431-95186551,chr9:95187364-95187484,chr9:95187864-95187984,chr9:95188364-95188484,chr9:95188864-95188984,chr9:95189364-95189484,chr9:95189864-95189984,chr9:95190872-95190992,chr9:95191957-95192077,chr9:95192864-95192984,chr9:95193415-95193535,chr9:95193864-95193984,chr9:95194362-95194482,chr9:95195864-95195984,chr9:95196402-95196522,chr9:95196865-95196985,chr9:95197864-95197984,chr9:95199364-95199484,chr9:95199864-95199984,chr9:95200413-95200533,chr9:95200864-95200984,chr9:95201364-95201484,chr9:95201864-95201984,chr9:95202364-95202484,chr9:95202864-95202984,chr9:95203376-95203496,chr9:95203902-95204022,chr9:95204364-95204484,chr9:95204864-95204984,chr9:95205364-95205484,chr9:95205864-95205984,chr9:95206364-95206484,chr9:95206864-95206984,chr9:95207364-95207484,chr9:95207864-95207984,chr9:95209364-95209484,chr9:95209868-95209988,chr9:95210364-95210484,chr9:95210864-95210984,chr9:95211401-95211521,chr9:95211876-95211996,chr9:95212364-95212484,chr9:95212836-95212956,chr9:95215326-95215446,chr9:95215888-95216008,chr9:95216368-95216488,chr9:95216848-95216968,chr9:95217864-95217984,chr9:95218970-95219090,chr9:95220853-95220973,chr9:95221864-95221984,chr9:95222364-95222484,chr9:95222864-95222984,chr9:95223364-95223484,chr9:95224864-95224984,chr9:95225364-95225484,chr9:95225864-95225984,chr9:95226364-95226484,chr9:95227364-95227484,chr9:95227864-95227984,chr9:95228818-95228938,chr9:95229418-95229538,chr9:95229864-95229984,chr9:95230340-95230460,chr9:95231818-95231938,chr9:95232364-95232484,chr9:95232864-95232984,chr9:95233364-95233484,chr9:95233864-95233984,chr9:95234301-95234421,chr9:95234864-95234984,chr9:95235867-95235987,chr9:95236364-95236484,chr9:95236864-95236984,chr9:95237364-95237484,chr9:95238364-95238484,chr9:95238853-95238973,chr9:95239364-95239484,chr9:95239864-95239984,chr9:95240364-95240484,chr9:95240950-95241070,chr9:95241939-95242059,chr9:95242364-95242484,chr9:95242864-95242984,chr9:95243364-95243484,chr9:95243864-95243984,chr9:95244301-95244421,chr9:95244827-95244947,chr9:95245250-95245370,chr9:95245946-95246066,chr9:95246864-95246984,chr9:95247364-95247484,chr9:95247864-95247984,chr9:95248364-95248484,chr9:95248864-95248984,chr9:95249364-95249484,chr9:95249864-95249984,chr9:95250364-95250484,chr9:95250864-95250984,chr9:95252364-95252484,chr9:95253356-95253476,chr9:95260864-95260984,chr9:95261364-95261484,chr9:95261864-95261984,chr9:95262312-95262432,chr9:95262864-95262984,chr9:95263864-95263984,chr9:95264364-95264484,chr9:95264864-95264984,chr9:95265364-95265484,chr9:95265864-95265984,chr9:95266364-95266484,chr9:95266864-95266984,chr9:95267864-95267984,chr9:95268367-95268487,chr9:95268864-95268984,chr9:95269364-95269484,chr9:95270364-95270484,chr9:95270864-95270984,chr9:95271364-95271484,chr9:95271830-95271950,chr9:95272355-95272475,chr9:95272842-95272962,chr9:95273364-95273484,chr9:95273864-95273984,chr9:95274864-95274984,chr9:95275865-95275985,chr9:95276364-95276484,chr9:95277458-95277578,chr9:95280364-95280484,chr9:95280864-95280984,chr9:95281364-95281484,chr9:95282364-95282484,chr9:95282956-95283076,chr9:95284364-95284484,chr9:95284930-95285050,chr9:95285364-95285484,chr9:95285864-95285984,chr9:95286364-95286484,chr9:95286864-95286984,chr9:95287364-95287484,chr9:95287864-95287984,chr9:95288364-95288484,chr9:95289417-95289537,chr9:95289938-95290058,chr9:95290484-95290604,chr9:95292391-95292511,chr9:95292864-95292984,chr9:95293364-95293484,chr9:95293864-95293984,chr9:95294364-95294484,chr9:95294864-95294984,chr9:95295864-95295984,chr9:95296364-95296484,chr9:95296864-95296984,chr9:95297364-95297484,chr9:95297835-95297955,chr9:95298364-95298484,chr9:95298864-95298984,chr9:95299364-95299484,chr9:95299864-95299984,chr9:95300355-95300475,chr9:95300864-95300984,chr9:95301317-95301437,chr9:95302422-95302542,chr9:95303364-95303484,chr9:95303827-95303947,chr9:95304307-95304427,chr9:95304864-95304984,chr9:95305364-95305484,chr9:95305864-95305984,chr9:95306364-95306484,chr9:95307364-95307484,chr9:95309364-95309484,chr9:95309839-95309959,chr9:95310364-95310484,chr9:95310864-95310984,chr9:95311364-95311484,chr9:95311864-95311984,chr9:95312864-95312984,chr9:95313364-95313484,chr9:95313864-95313984,chr9:95314864-95314984,chr9:95315864-95315984,chr9:95316364-95316484,chr9:95316864-95316984,chr9:95317364-95317484,chr9:95317864-95317984,chr9:95318917-95319037,chr9:95319864-95319984,chr9:95320411-95320531,chr9:95320914-95321034,chr9:95321364-95321484,chr9:95321864-95321984,chr9:95322364-95322484,chr9:95322976-95323096,chr9:95330364-95330484,chr9:95333364-95333484,chr9:95333864-95333984,chr9:95334357-95334477,chr9:95335364-95335484,chr9:95335864-95335984,chr9:95336364-95336484,chr9:95336861-95336981,chr9:95338859-95338979,chr9:95339328-95339448,chr9:95341364-95341484,chr9:95342364-95342484,chr9:95343454-95343574,chr9:95346336-95346456,chr9:95346864-95346984,chr9:95347896-95348016,chr9:95348985-95349105,chr9:95349867-95349987,chr9:95350364-95350484,chr9:95350885-95351005,chr9:95351364-95351484,chr9:95352365-95352485,chr9:95352864-95352984,chr9:95353364-95353484,chr9:95354809-95354929,chr9:95355364-95355484,chr9:95355864-95355984,chr9:95356364-95356484,chr9:95356846-95356966,chr9:95357440-95357560,chr9:95357864-95357984,chr9:95358365-95358485,chr9:95360342-95360462,chr9:95360864-95360984,chr9:95361813-95361933,chr9:95362364-95362484,chr9:95362864-95362984,chr9:95363364-95363484,chr9:95363864-95363984,chr9:95364364-95364484,chr9:95364864-95364984,chr9:95365364-95365484,chr9:95365864-95365984,chr9:95366309-95366429,chr9:95366864-95366984,chr9:95367864-95367984,chr9:95368362-95368482,chr9:95368864-95368984,chr9:95369864-95369984,chr9:95370364-95370484,chr9:95370791-95370911,chr9:95371864-95371984,chr9:95372310-95372430,chr9:95372864-95372984,chr9:95373364-95373484,chr9:95373864-95373984,chr9:95374364-95374484,chr9:95374864-95374984,chr9:95375432-95375552,chr9:95376841-95376961,chr9:95377346-95377466,chr9:95377864-95377984,chr9:95378364-95378484,chr9:95379864-95379984,chr9:95381365-95381485,chr9:95381915-95382035,chr9:95382440-95382560,chr9:95383364-95383484,chr9:95383864-95383984,chr9:95384364-95384484,chr9:95385368-95385488,chr9:95385864-95385984,chr9:95386364-95386484,chr9:95387472-95387592,chr9:95388326-95388446,chr9:95388864-95388984,chr9:95389909-95390029,chr9:95390364-95390484,chr9:95390864-95390984,chr9:95391364-95391484,chr9:95391883-95392003,chr9:95392864-95392984,chr9:95393364-95393484,chr9:95393821-95393941,chr9:95394364-95394484,chr9:95394864-95394984,chr9:95398364-95398484,chr9:95398864-95398984,chr9:95405364-95405484,chr9:95405831-95405951,chr9:95406364-95406484,chr9:95406864-95406984,chr9:95407364-95407484,chr9:95408475-95408595,chr9:95409353-95409473,chr9:95409935-95410055,chr9:95410364-95410484,chr9:95410864-95410984,chr9:95411364-95411484,chr9:95411864-95411984,chr9:95412398-95412518,chr9:95413364-95413484,chr9:95413824-95413944,chr9:95414274-95414394,chr9:95414958-95415078,chr9:95416332-95416452,chr9:95416812-95416932,chr9:95417364-95417484,chr9:95418364-95418484,chr9:95418876-95418996,chr9:95419364-95419484,chr9:95419826-95419946,chr9:95420364-95420484,chr9:95420864-95420984,chr9:95421467-95421587,chr9:95422864-95422984,chr9:95423364-95423484,chr9:95423954-95424074,chr9:95424434-95424554,chr9:95425274-95425394,chr9:95425980-95426100,chr9:95426864-95426984；
MRE11：
chr11:94415321-94415441,chr11:94416321-94416441,chr11:94416845-94416965,chr11:94417321-94417441,chr11:94417821-94417941,chr11:94418321-94418441,chr11:94418821-94418941,chr11:94419321-94419441,chr11:94419821-94419941,chr11:94420321-94420441,chr11:94421321-94421441,chr11:94421821-94421941,chr11:94422321-94422441,chr11:94423321-94423441,chr11:94423821-94423941,chr11:94429881-94430001,chr11:94430321-94430441,chr11:94430751-94430871,chr11:94431322-94431442,chr11:94431821-94431941,chr11:94432316-94432436,chr11:94432880-94433000,chr11:94433360-94433480,chr11:94433821-94433941,chr11:94434424-94434544,chr11:94434930-94435050,chr11:94435821-94435941,chr11:94436821-94436941,chr11:94437321-94437441,chr11:94437745-94437865,chr11:94438321-94438441,chr11:94438821-94438941,chr11:94439321-94439441,chr11:94440321-94440441,chr11:94440821-94440941,chr11:94441311-94441431,chr11:94442361-94442481,chr11:94442822-94442942,chr11:94443421-94443541,chr11:94443842-94443962,chr11:94444821-94444941,chr11:94445821-94445941,chr11:94446420-94446540,chr11:94447321-94447441,chr11:94447839-94447959,chr11:94448822-94448942,chr11:94449274-94449394,chr11:94450431-94450551,chr11:94451246-94451366,chr11:94451788-94451908,chr11:94452321-94452441,chr11:94453321-94453441,chr11:94453784-94453904,chr11:94454351-94454471,chr11:94454821-94454941,chr11:94455321-94455441,chr11:94455796-94455916,chr11:94456321-94456441,chr11:94456821-94456941,chr11:94457321-94457441,chr11:94458321-94458441,chr11:94458890-94459010,chr11:94459334-94459454,chr11:94460322-94460442,chr11:94460821-94460941,chr11:94463922-94464042,chr11:94464821-94464941,chr11:94465298-94465418,chr11:94466379-94466499,chr11:94466822-94466942,chr11:94467321-94467441,chr11:94467821-94467941,chr11:94468321-94468441,chr11:94469410-94469530,chr11:94470321-94470441,chr11:94470821-94470941,chr11:94471321-94471441,chr11:94471821-94471941,chr11:94472321-94472441,chr11:94472899-94473019,chr11:94473338-94473458,chr11:94473821-94473941,chr11:94474321-94474441,chr11:94474821-94474941,chr11:94475420-94475540,chr11:94476321-94476441,chr11:94477321-94477441,chr11:94478321-94478441,chr11:94478821-94478941,chr11:94479258-94479378,chr11:94479821-94479941,chr11:94480321-94480441,chr11:94480777-94480897,chr11:94481361-94481481,chr11:94481788-94481908,chr11:94482225-94482345,chr11:94482941-94483061,chr11:94484321-94484441,chr11:94484753-94484873,chr11:94485353-94485473,chr11:94485821-94485941,chr11:94486321-94486441,chr11:94486821-94486941,chr11:94487245-94487365,chr11:94487860-94487980,chr11:94488927-94489047,chr11:94489821-94489941,chr11:94490321-94490441,chr11:94490821-94490941,chr11:94491321-94491441,chr11:94491821-94491941,chr11:94492335-94492455,chr11:94492821-94492941,chr11:94493321-94493441,chr11:94493821-94493941,chr11:94494321-94494441,chr11:94494821-94494941,chr11:94495321-94495441,chr11:94495939-94496059,chr11:94496821-94496941,chr11:94497351-94497471,chr11:94497821-94497941,chr11:94498321-94498441,chr11:94498821-94498941,chr11:94499321-94499441,chr11:94499821-94499941,chr11:94500276-94500396,chr11:94500821-94500941,chr11:94501342-94501462,chr11:94501905-94502025,chr11:94502939-94503059,chr11:94503787-94503907,chr11:94504321-94504441,chr11:94504821-94504941,chr11:94506322-94506442,chr11:94506864-94506984,chr11:94507321-94507441,chr11:94507843-94507963,chr11:94508321-94508441,chr11:94509283-94509403,chr11:94509763-94509883,chr11:94510339-94510459,chr11:94510796-94510916,chr11:94511821-94511941,chr11:94512321-94512441；
NBS1：
chr8:89933302-89933422,chr8:89934221-89934341,chr8:89934721-89934841,chr8:89935335-89935455,chr8:89936330-89936450,chr8:89937221-89937341,chr8:89937709-89937829,chr8:89938721-89938841,chr8:89939223-89939343,chr8:89939721-89939841,chr8:89940221-89940341,chr8:89940721-89940841,chr8:89941220-89941340,chr8:89941721-89941841,chr8:89942221-89942341,chr8:89942721-89942841,chr8:89943221-89943341,chr8:89943721-89943841,chr8:89944859-89944979,chr8:89945721-89945841,chr8:89946221-89946341,chr8:89946721-89946841,chr8:89947721-89947841,chr8:89948221-89948341,chr8:89948721-89948841,chr8:89949326-89949446,chr8:89950721-89950841,chr8:89951311-89951431,chr8:89952183-89952303,chr8:89952720-89952840,chr8:89953221-89953341,chr8:89953721-89953841,chr8:89954221-89954341,chr8:89954721-89954841,chr8:89955221-89955341,chr8:89955721-89955841,chr8:89956221-89956341,chr8:89957764-89957884,chr8:89958244-89958364,chr8:89958721-89958841,chr8:89959221-89959341,chr8:89960221-89960341,chr8:89960817-89960937,chr8:89961721-89961841,chr8:89962221-89962341,chr8:89962721-89962841,chr8:89963221-89963341,chr8:89964255-89964375,chr8:89965224-89965344,chr8:89965769-89965889,chr8:89966221-89966341,chr8:89967323-89967443,chr8:89968233-89968353,chr8:89968656-89968776,chr8:89969221-89969341,chr8:89970241-89970361,chr8:89970721-89970841,chr8:89971221-89971341,chr8:89971721-89971841,chr8:89972221-89972341,chr8:89972721-89972841,chr8:89973222-89973342,chr8:89973707-89973827,chr8:89974221-89974341,chr8:89974650-89974770,chr8:89975221-89975341,chr8:89975721-89975841,chr8:89976733-89976853,chr8:89977808-89977928,chr8:89978721-89978841,chr8:89979258-89979378,chr8:89979704-89979824,chr8:89980221-89980341,chr8:89980721-89980841,chr8:89981221-89981341,chr8:89981721-89981841,chr8:89982221-89982341,chr8:89982721-89982841,chr8:89983207-89983327,chr8:89983721-89983841,chr8:89984221-89984341,chr8:89984721-89984841,chr8:89985221-89985341,chr8:89985710-89985830,chr8:89986221-89986341,chr8:89986759-89986879,chr8:89987221-89987341,chr8:89987721-89987841,chr8:89988221-89988341,chr8:89988721-89988841,chr8:89989222-89989342,chr8:89989721-89989841,chr8:89990221-89990341,chr8:89990721-89990841,chr8:89991721-89991841,chr8:89992221-89992341,chr8:89992767-89992887,chr8:89993221-89993341,chr8:89993745-89993865,chr8:89995721-89995841,chr8:89996221-89996341,chr8:89996721-89996841,chr8:89997221-89997341,chr8:89997721-89997841,chr8:89999221-89999341,chr8:90000221-90000341,chr8:90000721-90000841,chr8:90001221-90001341,chr8:90001721-90001841,chr8:90002178-90002298,chr8:90002721-90002841,chr8:90003221-90003341；
NF1：
chr17:31007684-31007804,chr17:31008184-31008304,chr17:31008724-31008844,chr17:31009184-31009304,chr17:31009684-31009804,chr17:31010184-31010304,chr17:31010684-31010804,chr17:31011184-31011304,chr17:31012184-31012304,chr17:31014684-31014804,chr17:31015184-31015304,chr17:31016280-31016400,chr17:31017184-31017304,chr17:31018684-31018804,chr17:31019705-31019825,chr17:31020184-31020304,chr17:31020719-31020839,chr17:31021154-31021274,chr17:31021684-31021804,chr17:31022190-31022310,chr17:31022684-31022804,chr17:31023170-31023290,chr17:31023699-31023819,chr17:31024185-31024305,chr17:31024684-31024804,chr17:31026184-31026304,chr17:31026684-31026804,chr17:31027691-31027811,chr17:31028184-31028304,chr17:31028611-31028731,chr17:31029184-31029304,chr17:31029684-31029804,chr17:31031122-31031242,chr17:31031765-31031885,chr17:31032684-31032804,chr17:31033184-31033304,chr17:31033703-31033823,chr17:31034184-31034304,chr17:31034684-31034804,chr17:31037184-31037304,chr17:31039684-31039804,chr17:31040207-31040327,chr17:31041184-31041304,chr17:31041617-31041737,chr17:31042185-31042305,chr17:31042685-31042805,chr17:31043751-31043871,chr17:31044184-31044304,chr17:31045684-31045804,chr17:31046184-31046304,chr17:31048184-31048304,chr17:31048684-31048804,chr17:31049184-31049304,chr17:31049684-31049804,chr17:31050684-31050804,chr17:31051684-31051804,chr17:31052156-31052276,chr17:31052684-31052804,chr17:31053238-31053358,chr17:31054152-31054272,chr17:31055112-31055232,chr17:31055722-31055842,chr17:31056184-31056304,chr17:31058263-31058383,chr17:31059211-31059331,chr17:31059685-31059805,chr17:31061184-31061304,chr17:31061684-31061804,chr17:31062184-31062304,chr17:31063265-31063385,chr17:31063742-31063862,chr17:31064184-31064304,chr17:31065122-31065242,chr17:31065684-31065804,chr17:31066184-31066304,chr17:31066684-31066804,chr17:31067684-31067804,chr17:31068184-31068304,chr17:31068684-31068804,chr17:31069244-31069364,chr17:31069784-31069904,chr17:31070672-31070792,chr17:31072184-31072304,chr17:31072685-31072805,chr17:31073290-31073410,chr17:31074184-31074304,chr17:31075184-31075304,chr17:31075684-31075804,chr17:31076155-31076275,chr17:31076752-31076872,chr17:31077684-31077804,chr17:31078184-31078304,chr17:31078684-31078804,chr17:31079684-31079804,chr17:31082738-31082858,chr17:31083184-31083304,chr17:31084154-31084274,chr17:31085684-31085804,chr17:31086184-31086304,chr17:31087184-31087304,chr17:31087736-31087856,chr17:31088233-31088353,chr17:31088684-31088804,chr17:31089193-31089313,chr17:31089684-31089804,chr17:31090671-31090791,chr17:31091184-31091304,chr17:31092269-31092389,chr17:31092960-31093080,chr17:31094184-31094304,chr17:31094684-31094804,chr17:31095184-31095304,chr17:31095684-31095804,chr17:31096184-31096304,chr17:31096684-31096804,chr17:31097604-31097724,chr17:31098184-31098304,chr17:31099184-31099304,chr17:31100184-31100304,chr17:31100684-31100804,chr17:31101184-31101304,chr17:31101684-31101804,chr17:31102184-31102304,chr17:31102729-31102849,chr17:31103159-31103279,chr17:31104184-31104304,chr17:31104684-31104804,chr17:31105185-31105305,chr17:31105792-31105912,chr17:31106684-31106804,chr17:31107184-31107304,chr17:31107736-31107856,chr17:31108679-31108799,chr17:31109184-31109304,chr17:31110776-31110896,chr17:31112163-31112283,chr17:31112685-31112805,chr17:31113123-31113243,chr17:31114203-31114323,chr17:31115283-31115403,chr17:31116265-31116385,chr17:31117260-31117380,chr17:31117739-31117859,chr17:31118184-31118304,chr17:31120779-31120899,chr17:31122184-31122304,chr17:31122684-31122804,chr17:31123184-31123304,chr17:31125184-31125304,chr17:31126191-31126311,chr17:31126791-31126911,chr17:31127751-31127871,chr17:31130684-31130804,chr17:31132571-31132691,chr17:31134185-31134305,chr17:31134684-31134804,chr17:31135184-31135304,chr17:31135684-31135804,chr17:31137239-31137359,chr17:31137684-31137804,chr17:31139684-31139804,chr17:31140184-31140304,chr17:31141282-31141402,chr17:31142184-31142304,chr17:31143128-31143248,chr17:31143680-31143800,chr17:31144184-31144304,chr17:31144684-31144804,chr17:31145684-31145804,chr17:31147184-31147304,chr17:31149180-31149300,chr17:31149684-31149804,chr17:31150139-31150259,chr17:31150619-31150739,chr17:31152184-31152304,chr17:31152684-31152804,chr17:31153184-31153304,chr17:31154635-31154755,chr17:31155184-31155304,chr17:31155684-31155804,chr17:31156184-31156304,chr17:31156684-31156804,chr17:31157268-31157388,chr17:31158185-31158305,chr17:31158684-31158804,chr17:31159184-31159304,chr17:31159684-31159804,chr17:31160684-31160804,chr17:31161184-31161304,chr17:31162071-31162191,chr17:31162684-31162804,chr17:31163184-31163304,chr17:31163684-31163804,chr17:31164538-31164658,chr17:31165589-31165709,chr17:31166184-31166304,chr17:31166684-31166804,chr17:31167184-31167304,chr17:31167684-31167804,chr17:31168684-31168804,chr17:31169184-31169304,chr17:31170184-31170304,chr17:31170684-31170804,chr17:31171184-31171304,chr17:31171684-31171804,chr17:31172707-31172827,chr17:31173614-31173734,chr17:31174073-31174193,chr17:31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PALB2：
chr16:23602948-23603068,chr16:23603448-23603568,chr16:23605063-23605183,chr16:23606013-23606133,chr16:23606448-23606568,chr16:23607565-23607685,chr16:23608442-23608562,chr16:23609061-23609181,chr16:23610585-23610705,chr16:23610657-23610777,chr16:23611948-23612068,chr16:23613948-23614068,chr16:23614448-23614568,chr16:23615948-23616068,chr16:23616448-23616568,chr16:23617340-23617460,chr16:23618488-23618608,chr16:23618948-23619068,chr16:23619497-23619617,chr16:23620058-23620178,chr16:23621448-23621568,chr16:23622032-23622152,chr16:23622948-23623068,chr16:23623948-23624068,chr16:23624948-23625068,chr16:23626448-23626568,chr16:23626948-23627068,chr16:23627497-23627617,chr16:23628448-23628568,chr16:23628949-23629069,chr16:23629448-23629568,chr16:23629948-23630068,chr16:23630448-23630568,chr16:23631551-23631671,chr16:23633452-23633572,chr16:23633984-23634104,chr16:23634948-23635068,chr16:23635448-23635568,chr16:23635948-23636068,chr16:23636448-23636568,chr16:23637948-23638068,chr16:23638448-23638568,chr16:23639017-23639137,chr16:23639948-23640068,chr16:23640513-23640633,chr16:23640948-23641068,chr16:23641448-23641568；
PGR：
chr11:101029335-101029455,chr11:101029835-101029955,chr11:101030335-101030455,chr11:101030835-101030955,chr11:101031335-101031455,chr11:101031835-101031955,chr11:101032335-101032455,chr11:101032835-101032955,chr11:101033335-101033455,chr11:101033835-101033955,chr11:101034335-101034455,chr11:101034835-101034955,chr11:101035335-101035455,chr11:101035835-101035955,chr11:101036335-101036455,chr11:101036835-101036955,chr11:101037311-101037431,chr11:101037819-101037939,chr11:101038335-101038455,chr11:101038835-101038955,chr11:101039335-101039455,chr11:101039885-101040005,chr11:101040835-101040955,chr11:101041285-101041405,chr11:101041835-101041955,chr11:101042335-101042455,chr11:101045219-101045339,chr11:101045928-101046048,chr11:101046429-101046549,chr11:101047335-101047455,chr11:101047834-101047954,chr11:101049835-101049955,chr11:101050335-101050455,chr11:101050879-101050999,chr11:101051335-101051455,chr11:101052335-101052455,chr11:101052835-101052955,chr11:101053335-101053455,chr11:101053836-101053956,chr11:101054335-101054455,chr11:101054836-101054956,chr11:101055423-101055543,chr11:101056256-101056376,chr11:101056835-101056955,chr11:101057300-101057420,chr11:101057780-101057900,chr11:101058335-101058455,chr11:101058835-101058955,chr11:101059335-101059455,chr11:101059850-101059970,chr11:101060335-101060455,chr11:101060835-101060955,chr11:101061335-101061455,chr11:101061835-101061955,chr11:101062335-101062455,chr11:101062835-101062955,chr11:101064341-101064461,chr11:101065335-101065455,chr11:101065835-101065955,chr11:101066335-101066455,chr11:101066835-101066955,chr11:101067378-101067498,chr11:101067835-101067955,chr11:101076451-101076571,chr11:101077335-101077455,chr11:101077835-101077955,chr11:101078335-101078455,chr11:101078800-101078920,chr11:101080335-101080455,chr11:101080835-101080955,chr11:101084835-101084955,chr11:101089368-101089488,chr11:101089819-101089939,chr11:101090335-101090455,chr11:101090798-101090918,chr11:101091260-101091380,chr11:101091835-101091955,chr11:101092335-101092455,chr11:101092835-101092955,chr11:101093335-101093455,chr11:101093835-101093955,chr11:101094335-101094455,chr11:101094835-101094955,chr11:101096335-101096455,chr11:101096835-101096955,chr11:101097353-101097473,chr11:101098335-101098455,chr11:101098835-101098955,chr11:101099835-101099955,chr11:101100448-101100568,chr11:101100946-101101066,chr11:101101786-101101906,chr11:101102375-101102495,chr11:101103335-101103455,chr11:101103792-101103912,chr11:101104335-101104455,chr11:101104835-101104955,chr11:101105310-101105430,chr11:101107335-101107455,chr11:101107835-101107955,chr11:101108447-101108567,chr11:101111335-101111455,chr11:101111835-101111955,chr11:101112335-101112455,chr11:101112835-101112955,chr11:101113835-101113955,chr11:101114335-101114455,chr11:101114835-101114955,chr11:101115295-101115415,chr11:101115789-101115909,chr11:101116335-101116455,chr11:101116796-101116916,chr11:101117363-101117483,chr11:101118335-101118455,chr11:101118827-101118947,chr11:101119335-101119455,chr11:101119806-101119926,chr11:101120335-101120455,chr11:101120802-101120922,chr11:101121335-101121455,chr11:101122335-101122455,chr11:101122835-101122955,chr11:101123335-101123455,chr11:101123814-101123934,chr11:101124335-101124455,chr11:101124835-101124955,chr11:101125335-101125455,chr11:101125835-101125955,chr11:101126335-101126455,chr11:101126835-101126955,chr11:101127335-101127455,chr11:101127835-101127955,chr11:101128335-101128455,chr11:101128835-101128955,chr11:101129335-101129455,chr11:101129835-101129955,chr11:101130335-101130455,chr11:101130835-101130955；
PIK3CA：
chr3:179148043-179148163,chr3:179148543-179148663,chr3:179149043-179149163,chr3:179149543-179149663,chr3:179150043-179150163,chr3:179150543-179150663,chr3:179151043-179151163,chr3:179151561-179151681,chr3:179152044-179152164,chr3:179152618-179152738,chr3:179153043-179153163,chr3:179153653-179153773,chr3:179154544-179154664,chr3:179155043-179155163,chr3:179156043-179156163,chr3:179156543-179156663,chr3:179157043-179157163,chr3:179157543-179157663,chr3:179158044-179158164,chr3:179158543-179158663,chr3:179159043-179159163,chr3:179160545-179160665,chr3:179161043-179161163,chr3:179162043-179162163,chr3:179163043-179163163,chr3:179163543-179163663,chr3:179164043-179164163,chr3:179164488-179164608,chr3:179165076-179165196,chr3:179165544-179165664,chr3:179166558-179166678,chr3:179167043-179167163,chr3:179168014-179168134,chr3:179169043-179169163,chr3:179169543-179169663,chr3:179170079-179170199,chr3:179170524-179170644,chr3:179171043-179171163,chr3:179171543-179171663,chr3:179172043-179172163,chr3:179172543-179172663,chr3:179173043-179173163,chr3:179173581-179173701,chr3:179174044-179174164,chr3:179174465-179174585,chr3:179175043-179175163,chr3:179175543-179175663,chr3:179176043-179176163,chr3:179176510-179176630,chr3:179177043-179177163,chr3:179177590-179177710,chr3:179178043-179178163,chr3:179178592-179178712,chr3:179179072-179179192,chr3:179179643-179179763,chr3:179180543-179180663,chr3:179181043-179181163,chr3:179181543-179181663,chr3:179182043-179182163,chr3:179182659-179182779,chr3:179183543-179183663,chr3:179184107-179184227,chr3:179184543-179184663,chr3:179185043-179185163,chr3:179186543-179186663,chr3:179187043-179187163,chr3:179188043-179188163,chr3:179188543-179188663,chr3:179189543-179189663,chr3:179190043-179190163,chr3:179190543-179190663,chr3:179191043-179191163,chr3:179191528-179191648,chr3:179192491-179192611,chr3:179193043-179193163,chr3:179193543-179193663,chr3:179194043-179194163,chr3:179194543-179194663,chr3:179195043-179195163,chr3:179196043-179196163,chr3:179196543-179196663,chr3:179197576-179197696,chr3:179198043-179198163,chr3:179198543-179198663,chr3:179199043-179199163,chr3:179199543-179199663,chr3:179200069-179200189,chr3:179200543-179200663,chr3:179201043-179201163,chr3:179201512-179201632,chr3:179201958-179202078,chr3:179202543-179202663,chr3:179203543-179203663,chr3:179204043-179204163,chr3:179204543-179204663,chr3:179205543-179205663,chr3:179205989-179206109,chr3:179206544-179206664,chr3:179207043-179207163,chr3:179208046-179208166,chr3:179208576-179208696,chr3:179209543-179209663,chr3:179210043-179210163,chr3:179210543-179210663,chr3:179213044-179213164,chr3:179215043-179215163,chr3:179215543-179215663,chr3:179217043-179217163,chr3:179217543-179217663,chr3:179218043-179218163,chr3:179218543-179218663,chr3:179219043-179219163,chr3:179219543-179219663,chr3:179220043-179220163,chr3:179220543-179220663,chr3:179221043-179221163,chr3:179221543-179221663,chr3:179222043-179222163,chr3:179223043-179223163,chr3:179223522-179223642,chr3:179224043-179224163,chr3:179224543-179224663,chr3:179225011-179225131,chr3:179225543-179225663,chr3:179226043-179226163,chr3:179226543-179226663,chr3:179227043-179227163,chr3:179227543-179227663,chr3:179228543-179228663,chr3:179229043-179229163,chr3:179229543-179229663,chr3:179230043-179230163,chr3:179233543-179233663,chr3:179234044-179234164,chr3:179234543-179234663,chr3:179235043-179235163,chr3:179235543-179235663,chr3:179236043-179236163,chr3:179236543-179236663,chr3:179237043-179237163,chr3:179237543-179237663,chr3:179238043-179238163,chr3:179238543-179238663,chr3:179239043-179239163,chr3:179239543-179239663,chr3:179240043-179240163；
RAD50：
chr5:132555873-132555993,chr5:132556310-132556430,chr5:132556873-132556993,chr5:132557373-132557493,chr5:132557873-132557993,chr5:132558992-132559112,chr5:132559902-132560022,chr5:132560336-132560456,chr5:132560873-132560993,chr5:132561862-132561982,chr5:132562373-132562493,chr5:132562873-132562993,chr5:132563373-132563493,chr5:132565373-132565493,chr5:132565873-132565993,chr5:132566373-132566493,chr5:132566955-132567075,chr5:132567873-132567993,chr5:132568422-132568542,chr5:132569373-132569493,chr5:132571339-132571459,chr5:132571873-132571993,chr5:132572936-132573056,chr5:132575436-132575556,chr5:132575873-132575993,chr5:132576373-132576493,chr5:132576812-132576932,chr5:132577490-132577610,chr5:132578328-132578448,chr5:132578873-132578993,chr5:132579373-132579493,chr5:132579873-132579993,chr5:132580373-132580493,chr5:132580873-132580993,chr5:132581397-132581517,chr5:132581873-132581993,chr5:132582416-132582536,chr5:132582873-132582993,chr5:132585373-132585493,chr5:132586873-132586993,chr5:132587438-132587558,chr5:132587873-132587993,chr5:132588373-132588493,chr5:132588873-132588993,chr5:132589873-132589993,chr5:132590466-132590586,chr5:132591373-132591493,chr5:132591873-132591993,chr5:132593402-132593522,chr5:132593873-132593993,chr5:132594438-132594558,chr5:132594873-132594993,chr5:132595373-132595493,chr5:132595873-132595993,chr5:132596373-132596493,chr5:132596873-132596993,chr5:132597373-132597493,chr5:132597873-132597993,chr5:132598317-132598437,chr5:132598922-132599042,chr5:132599886-132600006,chr5:132600474-132600594,chr5:132601373-132601493,chr5:132602373-132602493,chr5:132602798-132602918,chr5:132603373-132603493,chr5:132603873-132603993,chr5:132604873-132604993,chr5:132607383-132607503,chr5:132607873-132607993,chr5:132608873-132608993,chr5:132609373-132609493,chr5:132609873-132609993,chr5:132610373-132610493,chr5:132610804-132610924,chr5:132611402-132611522,chr5:132611873-132611993,chr5:132612839-132612959,chr5:132613374-132613494,chr5:132614362-132614482,chr5:132614873-132614993,chr5:132615373-132615493,chr5:132615873-132615993,chr5:132616373-132616493,chr5:132616873-132616993,chr5:132617316-132617436,chr5:132617873-132617993,chr5:132618873-132618993,chr5:132619304-132619424,chr5:132620355-132620475,chr5:132621873-132621993,chr5:132622833-132622953,chr5:132623873-132623993,chr5:132624373-132624493,chr5:132624874-132624994,chr5:132625299-132625419,chr5:132626449-132626569,chr5:132627272-132627392,chr5:132627873-132627993,chr5:132628348-132628468,chr5:132628944-132629064,chr5:132629373-132629493,chr5:132629873-132629993,chr5:132630373-132630493,chr5:132630966-132631086,chr5:132631399-132631519,chr5:132631874-132631994,chr5:132632360-132632480,chr5:132632823-132632943,chr5:132633423-132633543,chr5:132633903-132634023,chr5:132634373-132634493,chr5:132634966-132635086,chr5:132635873-132635993,chr5:132636373-132636493,chr5:132636873-132636993,chr5:132637373-132637493,chr5:132637873-132637993,chr5:132638373-132638493,chr5:132638873-132638993,chr5:132639373-132639493,chr5:132639873-132639993,chr5:132640373-132640493,chr5:132640873-132640993,chr5:132641373-132641493,chr5:132641873-132641993,chr5:132642373-132642493,chr5:132643373-132643493,chr5:132643873-132643993,chr5:132644434-132644554,chr5:132645394-132645514；
RAD51B：
chr14:67819688-67819808,chr14:67820111-67820231,chr14:67820688-67820808,chr14:67821301-67821421,chr14:67821731-67821851,chr14:67822188-67822308,chr14:67822720-67822840,chr14:67823188-67823308,chr14:67823688-67823808,chr14:67824688-67824808,chr14:67825188-67825308,chr14:67825641-67825761,chr14:67826188-67826308,chr14:67827188-67827308,chr14:67829654-67829774,chr14:67830188-67830308,chr14:67830734-67830854,chr14:67831214-67831334,chr14:67832689-67832809,chr14:67833763-67833883,chr14:67834188-67834308,chr14:67835188-67835308,chr14:67836188-67836308,chr14:67836798-67836918,chr14:67838257-67838377,chr14:67838739-67838859,chr14:67839188-67839308,chr14:67839688-67839808,chr14:67844188-67844308,chr14:67846188-67846308,chr14:67846688-67846808,chr14:67850259-67850379,chr14:67850698-67850818,chr14:67851188-67851308,chr14:67851651-67851771,chr14:67852188-67852308,chr14:67852731-67852851,chr14:67853688-67853808,chr14:67854945-67855065,chr14:67855689-67855809,chr14:67856192-67856312,chr14:67856688-67856808,chr14:67857188-67857308,chr14:67857620-67857740,chr14:67858792-67858912,chr14:67859733-67859853,chr14:67860188-67860308,chr14:67861173-67861293,chr14:67861688-67861808,chr14:67862262-67862382,chr14:67862688-67862808,chr14:67863688-67863808,chr14:67864214-67864334,chr14:67865144-67865264,chr14:67866309-67866429,chr14:67867160-67867280,chr14:67867688-67867808,chr14:67874188-67874308,chr14:67874688-67874808,chr14:67875188-67875308,chr14:67875731-67875851,chr14:67876188-67876308,chr14:67876688-67876808,chr14:67877131-67877251,chr14:67878188-67878308,chr14:67879188-67879308,chr14:67880188-67880308,chr14:67880688-67880808,chr14:67881205-67881325,chr14:67881685-67881805,chr14:67882285-67882405,chr14:67883133-67883253,chr14:67883688-67883808,chr14:67884188-67884308,chr14:67884688-67884808,chr14:67885188-67885308,chr14:67885688-67885808,chr14:67886109-67886229,chr14:67886741-67886861,chr14:67887235-67887355,chr14:67887688-67887808,chr14:67888188-67888308,chr14:67889188-67889308,chr14:67889688-67889808,chr14:67890688-67890808,chr14:67891188-67891308,chr14:67891688-67891808,chr14:67892188-67892308,chr14:67892688-67892808,chr14:67893183-67893303,chr14:67893688-67893808,chr14:67894179-67894299,chr14:67894679-67894799,chr14:67895188-67895308,chr14:67895689-67895809,chr14:67896188-67896308,chr14:67896688-67896808,chr14:67898697-67898817,chr14:67899607-67899727,chr14:67900188-67900308,chr14:67900688-67900808,chr14:67901188-67901308,chr14:67902205-67902325,chr14:67902688-67902808,chr14:67903188-67903308,chr14:67907811-67907931,chr14:67908265-67908385,chr14:67909188-67909308,chr14:67910188-67910308,chr14:67910688-67910808,chr14:67911188-67911308,chr14:67911785-67911905,chr14:67912611-67912731,chr14:67913132-67913252,chr14:67914581-67914701,chr14:67915221-67915341,chr14:67915688-67915808,chr14:67916171-67916291,chr14:67916688-67916808,chr14:67917688-67917808,chr14:67918136-67918256,chr14:67918688-67918808,chr14:67919168-67919288,chr14:67919779-67919899,chr14:67920797-67920917,chr14:67922148-67922268,chr14:67927119-67927239,chr14:67927703-67927823,chr14:67930188-67930308,chr14:67932727-67932847,chr14:67934188-67934308,chr14:67934688-67934808,chr14:67935188-67935308,chr14:67935688-67935808,chr14:67936188-67936308,chr14:67936688-67936808,chr14:67937253-67937373,chr14:67937688-67937808,chr14:67938188-67938308,chr14:67938710-67938830,chr14:67939188-67939308,chr14:67939688-67939808,chr14:67940621-67940741,chr14:67941188-67941308,chr14:67941688-67941808,chr14:67942188-67942308,chr14:67942688-67942808,chr14:67943189-67943309,chr14:67943722-67943842,chr14:67944188-67944308,chr14:67945196-67945316,chr14:67946188-67946308,chr14:67946688-67946808,chr14:67947188-67947308,chr14:67947688-67947808,chr14:67948188-67948308,chr14:67950744-67950864,chr14:67951196-67951316,chr14:67951688-67951808,chr14:67952306-67952426,chr14:67953092-67953212,chr14:67954188-67954308,chr14:67954688-67954808,chr14:67955108-67955228,chr14:67955705-67955825,chr14:67957189-67957309,chr14:67957688-67957808,chr14:67958188-67958308,chr14:67958688-67958808,chr14:67959154-67959274,chr14:67959688-67959808,chr14:67960188-67960308,chr14:67961283-67961403,chr14:67962188-67962308,chr14:67962688-67962808,chr14:67963209-67963329,chr14:67963688-67963808,chr14:67964188-67964308,chr14:67964688-67964808,chr14:67965188-67965308,chr14:67965688-67965808,chr14:67966188-67966308,chr14:67969205-67969325,chr14:67969688-67969808,chr14:67970188-67970308,chr14:67970688-67970808,chr14:67971188-67971308,chr14:67971678-67971798,chr14:67972188-67972308,chr14:67972688-67972808,chr14:67973188-67973308,chr14:67973688-67973808,chr14:67974188-67974308,chr14:67974688-67974808,chr14:67975188-67975308,chr14:67977188-67977308,chr14:67977688-67977808,chr14:67978188-67978308,chr14:67978688-67978808,chr14:67979688-67979808,chr14:67980688-67980808,chr14:67981126-67981246,chr14:67981726-67981846,chr14:67982681-67982801,chr14:67983188-67983308,chr14:67983688-67983808,chr14:67984216-67984336,chr14:67984641-67984761,chr14:67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chr14:68664188-68664308,chr14:68664688-68664808,chr14:68665188-68665308,chr14:68665669-68665789,chr14:68666688-68666808,chr14:68667188-68667308,chr14:68668188-68668308,chr14:68668688-68668808,chr14:68669188-68669308,chr14:68669688-68669808,chr14:68670188-68670308,chr14:68670688-68670808,chr14:68671188-68671308,chr14:68671796-68671916,chr14:68672688-68672808,chr14:68673172-68673292,chr14:68673688-68673808,chr14:68674252-68674372,chr14:68674688-68674808,chr14:68675188-68675308,chr14:68675688-68675808,chr14:68676688-68676808,chr14:68677188-68677308,chr14:68677688-68677808,chr14:68678189-68678309,chr14:68678739-68678859,chr14:68679688-68679808,chr14:68680688-68680808,chr14:68681188-68681308,chr14:68681688-68681808,chr14:68682188-68682308,chr14:68682688-68682808,chr14:68683188-68683308,chr14:68683688-68683808,chr14:68684300-68684420,chr14:68685188-68685308,chr14:68685688-68685808,chr14:68686188-68686308,chr14:68687188-68687308,chr14:68687651-68687771,chr14:68688688-68688808,chr14:68689188-68689308,chr14:68689688-68689808,chr14:68690188-68690308,chr14:68690688-68690808,chr14:68691188-68691308,chr14:68691688-68691808,chr14:68692188-68692308,chr14:68692715-68692835,chr14:68693188-68693308,chr14:68693688-68693808,chr14:68694188-68694308,chr14:68694688-68694808,chr14:68695188-68695308,chr14:68695688-68695808,chr14:68696200-68696320,chr14:68696688-68696808,chr14:68697188-68697308,chr14:68699688-68699808,chr14:68702188-68702308,chr14:68702689-68702809,chr14:68703188-68703308,chr14:68703736-68703856,chr14:68704189-68704309,chr14:68704689-68704809,chr14:68705188-68705308,chr14:68705688-68705808,chr14:68706188-68706308,chr14:68706688-68706808,chr14:68707248-68707368,chr14:68707688-68707808,chr14:68708188-68708308,chr14:68708661-68708781,chr14:68709104-68709224,chr14:68709793-68709913,chr14:68710688-68710808,chr14:68711188-68711308,chr14:68711688-68711808,chr14:68712688-68712808,chr14:68713188-68713308,chr14:68713688-68713808,chr14:68714188-68714308,chr14:68714779-68714899,chr14:68715750-68715870,chr14:68716688-68716808,chr14:68717249-68717369,chr14:68717688-68717808,chr14:68718144-68718264,chr14:68718614-68718734,chr14:68719107-68719227,chr14:68719688-68719808,chr14:68720188-68720308,chr14:68721188-68721308,chr14:68721688-68721808,chr14:68722141-68722261,chr14:68722754-68722874,chr14:68723188-68723308,chr14:68723688-68723808,chr14:68724188-68724308,chr14:68725164-68725284,chr14:68725688-68725808,chr14:68726688-68726808,chr14:68727190-68727310,chr14:68727688-68727808,chr14:68728188-68728308,chr14:68728703-68728823,chr14:68729688-68729808,chr14:68730188-68730308；
RAD51C：
chr17:58692263-58692383,chr17:58692763-58692883,chr17:58693263-58693383,chr17:58693850-58693970,chr17:58694763-58694883,chr17:58695263-58695383,chr17:58696763-58696883,chr17:58699320-58699440,chr17:58700314-58700434,chr17:58700763-58700883,chr17:58701842-58701962,chr17:58702263-58702383,chr17:58703263-58703383,chr17:58704730-58704850,chr17:58705690-58705810,chr17:58708847-58708967,chr17:58709356-58709476,chr17:58710763-58710883,chr17:58711263-58711383,chr17:58711764-58711884,chr17:58712349-58712469,chr17:58713236-58713356,chr17:58714277-58714397,chr17:58715728-58715848,chr17:58716237-58716357,chr17:58717764-58717884,chr17:58718275-58718395,chr17:58718763-58718883,chr17:58719675-58719795,chr17:58720763-58720883,chr17:58721265-58721385,chr17:58721764-58721884,chr17:58722232-58722352,chr17:58722763-58722883,chr17:58723250-58723370,chr17:58723763-58723883,chr17:58724263-58724383,chr17:58724763-58724883,chr17:58725263-58725383,chr17:58726263-58726383,chr17:58727403-58727523,chr17:58728264-58728384,chr17:58728763-58728883,chr17:58729850-58729970,chr17:58730680-58730800,chr17:58731860-58731980,chr17:58732763-58732883,chr17:58733294-58733414,chr17:58734263-58734383,chr17:58734874-58734994；
RAD51D：
chr17:35092054-35092174,chr17:35092646-35092766,chr17:35093523-35093643,chr17:35094005-35094125,chr17:35094554-35094674,chr17:35095980-35096100,chr17:35096460-35096580,chr17:35097024-35097144,chr17:35097555-35097675,chr17:35098054-35098174,chr17:35099133-35099253,chr17:35099554-35099674,chr17:35100054-35100174,chr17:35100554-35100674,chr17:35101054-35101174,chr17:35102062-35102182,chr17:35102635-35102755,chr17:35103055-35103175,chr17:35103554-35103674,chr17:35104079-35104199,chr17:35104663-35104783,chr17:35105113-35105233,chr17:35105554-35105674,chr17:35106036-35106156,chr17:35106487-35106607,chr17:35107054-35107174,chr17:35107554-35107674,chr17:35108594-35108714,chr17:35113054-35113174,chr17:35113555-35113675,chr17:35115054-35115174,chr17:35116054-35116174,chr17:35116954-35117074,chr17:35118012-35118132,chr17:35118554-35118674,chr17:35119055-35119175,chr17:35119554-35119674,chr17:35120599-35120719,chr17:35121054-35121174,chr17:35121554-35121674；
RECQL4：
chr8:144511004-144511124,chr8:144511487-144511607,chr8:144512004-144512124,chr8:144512504-144512624,chr8:144513004-144513124,chr8:144513503-144513623,chr8:144514003-144514123,chr8:144514503-144514623,chr8:144515003-144515123,chr8:144515503-144515623,chr8:144516003-144516123,chr8:144516503-144516623,chr8:144517003-144517123,chr8:144517476-144517596,chr8:144518003-144518123；
RECQL5：
chr17:75626707-75626827,chr17:75627207-75627327,chr17:75627640-75627760,chr17:75628207-75628327,chr17:75628707-75628827,chr17:75629207-75629327,chr17:75629707-75629827,chr17:75630207-75630327,chr17:75630707-75630827,chr17:75631207-75631327,chr17:75631652-75631772,chr17:75632707-75632827,chr17:75633207-75633327,chr17:75633707-75633827,chr17:75634207-75634327,chr17:75634707-75634827,chr17:75635207-75635327,chr17:75635707-75635827,chr17:75636207-75636327,chr17:75636707-75636827,chr17:75637207-75637327,chr17:75637707-75637827,chr17:75638707-75638827,chr17:75639207-75639327,chr17:75639707-75639827,chr17:75640207-75640327,chr17:75640692-75640812,chr17:75641207-75641327,chr17:75641707-75641827,chr17:75642207-75642327,chr17:75643207-75643327,chr17:75643632-75643752,chr17:75644590-75644710,chr17:75645166-75645286,chr17:75645646-75645766,chr17:75646207-75646327,chr17:75646707-75646827,chr17:75647207-75647327,chr17:75647707-75647827,chr17:75648270-75648390,chr17:75649207-75649327,chr17:75649707-75649827,chr17:75650207-75650327,chr17:75650707-75650827,chr17:75651207-75651327,chr17:75651707-75651827,chr17:75652235-75652355,chr17:75652707-75652827,chr17:75653207-75653327,chr17:75654207-75654327,chr17:75655070-75655190,chr17:75656636-75656756,chr17:75657207-75657327,chr17:75658207-75658327,chr17:75659784-75659904,chr17:75660707-75660827,chr17:75661328-75661448,chr17:75662207-75662327,chr17:75662707-75662827,chr17:75663644-75663764,chr17:75664207-75664327,chr17:75665275-75665395,chr17:75665708-75665828,chr17:75666256-75666376,chr17:75666707-75666827,chr17:75667207-75667327；
WRN：
chr8:31033028-31033148,chr8:31033528-31033648,chr8:31034028-31034148,chr8:31034515-31034635,chr8:31035073-31035193,chr8:31035634-31035754,chr8:31038528-31038648,chr8:31040028-31040148,chr8:31040528-31040648,chr8:31040982-31041102,chr8:31041582-31041702,chr8:31042028-31042148,chr8:31042528-31042648,chr8:31043033-31043153,chr8:31043528-31043648,chr8:31045029-31045149,chr8:31046047-31046167,chr8:31046528-31046648,chr8:31047028-31047148,chr8:31047528-31047648,chr8:31048028-31048148,chr8:31048552-31048672,chr8:31049528-31049648,chr8:31050140-31050260,chr8:31050580-31050700,chr8:31051028-31051148,chr8:31052122-31052242,chr8:31053028-31053148,chr8:31053528-31053648,chr8:31054028-31054148,chr8:31054541-31054661,chr8:31056028-31056148,chr8:31056528-31056648,chr8:31057028-31057148,chr8:31057576-31057696,chr8:31058028-31058148,chr8:31058528-31058648,chr8:31059028-31059148,chr8:31059528-31059648,chr8:31060057-31060177,chr8:31060542-31060662,chr8:31061028-31061148,chr8:31061528-31061648,chr8:31062028-31062148,chr8:31063058-31063178,chr8:31063528-31063648,chr8:31064480-31064600,chr8:31065028-31065148,chr8:31066528-31066648,chr8:31067028-31067148,chr8:31067528-31067648,chr8:31068028-31068148,chr8:31068528-31068648,chr8:31069028-31069148,chr8:31070016-31070136,chr8:31071063-31071183,chr8:31072023-31072143,chr8:31072592-31072712,chr8:31073028-31073148,chr8:31073528-31073648,chr8:31074528-31074648,chr8:31075028-31075148,chr8:31075528-31075648,chr8:31076028-31076148,chr8:31076528-31076648,chr8:31077028-31077148,chr8:31077528-31077648,chr8:31078413-31078533,chr8:31079028-31079148,chr8:31079528-31079648,chr8:31080528-31080648,chr8:31081028-31081148,chr8:31081533-31081653,chr8:31082040-31082160,chr8:31082505-31082625,chr8:31082999-31083119,chr8:31083562-31083682,chr8:31084472-31084592,chr8:31085029-31085149,chr8:31086028-31086148,chr8:31087028-31087148,chr8:31087528-31087648,chr8:31088028-31088148,chr8:31088528-31088648,chr8:31089028-31089148,chr8:31089463-31089583,chr8:31090136-31090256,chr8:31091028-31091148,chr8:31091564-31091684,chr8:31092028-31092148,chr8:31092599-31092719,chr8:31095028-31095148,chr8:31095528-31095648,chr8:31096528-31096648,chr8:31097484-31097604,chr8:31098028-31098148,chr8:31098528-31098648,chr8:31099437-31099557,chr8:31100028-31100148,chr8:31100589-31100709,chr8:31101028-31101148,chr8:31102028-31102148,chr8:31104528-31104648,chr8:31105028-31105148,chr8:31106028-31106148,chr8:31106571-31106691,chr8:31107141-31107261,chr8:31108028-31108148,chr8:31108528-31108648,chr8:31109028-31109148,chr8:31109518-31109638,chr8:31110028-31110148,chr8:31110528-31110648,chr8:31111028-31111148,chr8:31111528-31111648,chr8:31111949-31112069,chr8:31112504-31112624,chr8:31113528-31113648,chr8:31114028-31114148,chr8:31114528-31114648,chr8:31115591-31115711,chr8:31116127-31116247,chr8:31117029-31117149,chr8:31117528-31117648,chr8:31118028-31118148,chr8:31118528-31118648,chr8:31119028-31119148,chr8:31119528-31119648,chr8:31120028-31120148,chr8:31120528-31120648,chr8:31121028-31121148,chr8:31121528-31121648,chr8:31122028-31122148,chr8:31122529-31122649,chr8:31123528-31123648,chr8:31124028-31124148,chr8:31124528-31124648,chr8:31125028-31125148,chr8:31125501-31125621,chr8:31125981-31126101,chr8:31126581-31126701,chr8:31127488-31127608,chr8:31128480-31128600,chr8:31128931-31129051,chr8:31129623-31129743,chr8:31130143-31130263,chr8:31131528-31131648,chr8:31132028-31132148,chr8:31132528-31132648,chr8:31133028-31133148,chr8:31133529-31133649,chr8:31134028-31134148,chr8:31134528-31134648,chr8:31134991-31135111,chr8:31135528-31135648,chr8:31136459-31136579,chr8:31137028-31137148,chr8:31137523-31137643,chr8:31138092-31138212,chr8:31138541-31138661,chr8:31139028-31139148,chr8:31139528-31139648,chr8:31140528-31140648,chr8:31141028-31141148,chr8:31141528-31141648,chr8:31142528-31142648,chr8:31143078-31143198,chr8:31143528-31143648,chr8:31146028-31146148,chr8:31146595-31146715,chr8:31147028-31147148,chr8:31147528-31147648,chr8:31148528-31148648,chr8:31149017-31149137,chr8:31150028-31150148,chr8:31150528-31150648,chr8:31151528-31151648,chr8:31152028-31152148,chr8:31152535-31152655,chr8:31153028-31153148,chr8:31153528-31153648,chr8:31154028-31154148,chr8:31154528-31154648,chr8:31155028-31155148,chr8:31155620-31155740,chr8:31156528-31156648,chr8:31157028-31157148,chr8:31157528-31157648,chr8:31158028-31158148,chr8:31158528-31158648,chr8:31159529-31159649,chr8:31160028-31160148,chr8:31160528-31160648,chr8:31160995-31161115,chr8:31163028-31163148,chr8:31163528-31163648,chr8:31164117-31164237,chr8:31165029-31165149,chr8:31166028-31166148,chr8:31166528-31166648,chr8:31167028-31167148,chr8:31167528-31167648,chr8:31168028-31168148,chr8:31168528-31168648,chr8:31169028-31169148,chr8:31169528-31169648,chr8:31170028-31170148,chr8:31170528-31170648,chr8:31171528-31171648,chr8:31172028-31172148,chr8:31172528-31172648,chr8:31173028-31173148,chr8:31173528-31173648,chr8:31174106-31174226,chr8:31174995-31175115,chr8:31175528-31175648。
5. a breast cancer diagnostic reagent comprising the probe set according to any one of claims 1 to 4 and a library reagent.
6. The breast cancer diagnostic reagent of claim 5, further comprising a linker a, a linker B, a pre-amplification primer;
the sequence of the joint A is as follows:
gcagtcgaacatgtagctgactcaggtcac(N)xggtagt；
the sequence of the connector B is as follows:
ctacc(N)x gtgacctgagtcagctacatgttcgactgc；
the 5' end of the connector B is modified by phosphorylation, in (N) x, N is any one of A, G, C, T bases, and the number of x is 10-20;
the sequences of the pre-amplification primers are as follows: gcagtcgaacatgtagctgactcaggtcac.
7. The breast cancer diagnostic reagent of claim 5 or 6, wherein the pooling reagent comprises: DNA disruption reagent, end repair reagent and adaptor reagent, library pre-amplification reagent, hybridization capture reagent and hybridization elution reagent.
8. Use of the probe set according to any one of claims 1 to 4, the breast cancer diagnostic reagent according to any one of claims 5 to 7 for the preparation of a breast cancer diagnostic product.
9. The breast cancer sequencing library is characterized by comprising the following construction methods:
after breaking the genome DNA, repairing the tail end, adding the joint A and the joint B to obtain library solution;
after amplifying the library solution with the pre-amplification primer, capturing with the probe set according to any one of claims 1 to 4, and then enriching with magnetic beads.
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