CN117451463B - Sample pretreatment equipment for detecting psychotropic drugs in serum - Google Patents
Sample pretreatment equipment for detecting psychotropic drugs in serum Download PDFInfo
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- CN117451463B CN117451463B CN202311777595.7A CN202311777595A CN117451463B CN 117451463 B CN117451463 B CN 117451463B CN 202311777595 A CN202311777595 A CN 202311777595A CN 117451463 B CN117451463 B CN 117451463B
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- 229940001470 psychoactive drug Drugs 0.000 title claims abstract description 29
- 239000004089 psychotropic agent Substances 0.000 title claims abstract description 29
- 210000002966 serum Anatomy 0.000 title claims abstract description 21
- 238000012360 testing method Methods 0.000 claims abstract description 41
- 239000007788 liquid Substances 0.000 claims description 29
- 239000011324 bead Substances 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 25
- 238000009423 ventilation Methods 0.000 claims description 25
- 230000003014 reinforcing effect Effects 0.000 claims description 11
- 238000009434 installation Methods 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 239000004065 semiconductor Substances 0.000 claims description 6
- 239000013585 weight reducing agent Substances 0.000 claims description 3
- 208000016261 weight loss Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 22
- 229940079593 drug Drugs 0.000 abstract description 18
- 230000003340 mental effect Effects 0.000 abstract description 5
- 238000000926 separation method Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 19
- 239000000523 sample Substances 0.000 description 19
- 239000000243 solution Substances 0.000 description 17
- 230000008569 process Effects 0.000 description 13
- 238000005119 centrifugation Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- 238000005057 refrigeration Methods 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 4
- 239000012224 working solution Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B15/00—Other accessories for centrifuges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
Abstract
The invention provides sample pretreatment equipment for detecting psychotropic drugs in serum, and relates to the technical field of psychotropic drug concentration pretreatment equipment. The sample pretreatment equipment for the mental drugs comprises a bottom plate, wherein mounting plates are fixedly connected to two sides of the upper surface of the bottom plate, connecting blocks are fixedly connected to the lower parts of one ends of the mounting plates, which are close to the center of the bottom plate, connecting seats are fixedly connected to one ends of the connecting blocks, which are close to the center of the bottom plate, connecting frames are fixedly connected to the middle parts of the lower surfaces of the connecting seats, and second servo motors are fixedly connected to the middle parts of the inner bottom surfaces of the connecting frames. The invention provides sample pretreatment equipment for detecting a psychotropic drug in serum, which can freely adjust the inclination angle of a test tube, is further suitable for samples with different viscosities and difficult separation, and brings convenience for practical use of staff.
Description
Technical Field
The invention relates to the technical field of concentration pretreatment equipment for psychotropic drugs, in particular to sample pretreatment equipment for detecting psychotropic drugs in serum.
Background
The medical monitoring and research professional committee of the Chinese pharmacology society has a clear definition on the monitoring of the concentration of therapeutic drugs (TherapeuticDrugMonitoring, TDM) in the "medical monitoring and work Specification expert consensus" (2019 edition): TDM is a pharmaceutical clinical discipline that explores the mechanisms, techniques, methods and clinical criteria of personalized medicine treatment and transforms the study results into clinical treatments to maximize the administration of the chemical compounds. By measuring the drug exposure, pharmacological markers or pharmacodynamic indexes in the patient, a quantitative pharmacological model is utilized to prepare an individual dosing scheme suitable for the patient based on a drug treatment window. The core is individuation drug treatment. Therapeutic drug monitoring is a new medical branch formed in the last 20 years and is the result of close combination of clinical pharmacology and drug concentration determination technology. The method quantitatively analyzes the concentration of the medicine and the metabolite in biological samples (including blood, urine, saliva and the like) through various modern test means, explores the safe range of the blood concentration, calculates the optimal dosage, the dosing interval time and the like by applying various pharmacokinetics methods, and realizes individuation of a dosing scheme, thereby safely, effectively and economically using the medicine.
When the pretreatment of the sample for detecting the psychotropic drugs in serum is carried out, the test serum sample is usually required to be collected, proper identification and storage are ensured, the collected blood sample is centrifuged to obtain a serum part, the serum is a liquid part which does not contain red blood cells and clots in blood, and the centrifugation technology or other blood separation technologies are commonly used for realizing, however, the conventional pretreatment equipment for the psychotropic drugs is usually inconvenient to store test tubes after centrifugation, and meanwhile, the conventional pretreatment equipment for the psychotropic drugs is usually easy to shake and noise integrally in the working process by using the centrifuge, so that the stability and the safety of the equipment are difficult to be ensured, the centrifugation process of the test tubes and the centrifugation quality of drugs are influenced, and therefore, technical improvement is urgently needed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides sample pretreatment equipment for detecting the psychotropic drugs in serum, which solves the problems that the traditional sample pretreatment equipment for the psychotropic drugs is easy to shake integrally and generate noise in the working process, and further the stability and the safe operation of the equipment are difficult to ensure.
In order to achieve the above purpose, the invention is realized by the following technical scheme: the utility model provides a sample pretreatment equipment for detecting spirit class medicine in serum, includes the bottom plate, the both sides of bottom plate upper surface are all fixedly connected with mounting panel, the lower part that the mounting panel is close to bottom plate center department one end is all fixedly connected with connecting block, the one end that the connecting block is close to bottom plate center department is all fixedly connected with connecting seat, the middle part fixedly connected with link of connecting seat lower surface, the middle part fixedly connected with second servo motor of bottom surface in the link, the output of second servo motor runs through the connecting seat and fixedly connected with centrifugation seat, first spout and second spout have been seted up respectively to the outer wall of centrifugation seat lower extreme, the inner wall of connecting seat is a plurality of first rotation balls and second rotation balls of rotation connection respectively, first rotation balls are at the inside sliding connection of first spout, second rotation balls are at the inside sliding connection of second spout;
the middle part of the inner bottom surface of the centrifugal seat is fixedly connected with two V-shaped mounting plates, three reinforcing columns are fixedly connected to adjacent ends of the V-shaped mounting plates, reinforcing blocks are fixedly connected to one ends of the V-shaped mounting plates, which are far away from the center of the centrifugal seat, of the V-shaped mounting plates, two connecting columns are fixedly connected to the upper surfaces of the reinforcing blocks respectively, rectangular mounting plates are fixedly connected to the upper surfaces of the connecting columns, fixing seats are fixedly connected to the upper surfaces of the rectangular mounting plates and the V-shaped mounting plates, arc-shaped fixing grooves are formed in the upper surfaces of the fixing seats, and test tube placing racks are fixedly connected to the inner parts of the arc-shaped fixing grooves;
the outer wall of the upper end of the centrifugal seat is provided with a limit groove and a third sliding groove respectively, the middle part of one end of the mounting plate, which is close to the center of the bottom plate, is fixedly connected with a limit cover, the inside of the limit cover is fixedly connected with a plurality of springs, one end of each spring, which is close to the center of the centrifugal seat, is fixedly connected with a first limit arc plate, the middle part of each first limit arc plate is rotationally connected with a plurality of third rotating beads, the third rotating beads are in sliding connection with the inside of the limit groove, the two sides of the outer wall of the front end and the rear end of the connecting seat are fixedly connected with support plates, one end of the upper end of each support plate, which is close to the center of the centrifugal seat, is fixedly connected with a second limit arc plate, the middle part of each second limit arc plate is rotationally connected with a fourth rotating bead, and the fourth rotating beads are in sliding connection with the inside of the third sliding groove;
the middle part fixedly connected with storage box of bottom plate upper surface, the middle part of storage box both sides outer wall is fixedly connected with three semiconductor refrigerator respectively, the inside of storage box is provided with two storage boxes, the lower surface of storage box and the outer wall of both sides have all seted up first ventilation slot, the one end that first ventilation slot is close to storage box center department has all seted up a plurality of first ventilation rectangular holes, the outer wall that storage box is close to storage box center department one end all has seted up the second ventilation slot, a plurality of second ventilation rectangular holes have all been seted up to the both sides of second ventilation slot, the one end that storage box is close to storage box center department all has seted up a plurality of ventilation round holes, the interior bottom surface of storage box all fixedly connected with three slide, three fixed slots have all been seted up to the lower surface of storage box, the fixed slot all is at the outer wall sliding connection of slide, one side of storage box front end and rear end all articulates and is connected with the sealing door;
two first assembly grooves are respectively formed in two sides of the inner top surface of the storage box, second assembly grooves are respectively formed in the upper ends and the lower ends of the inner walls of the two sides of the storage box, baffles are respectively arranged in the two sides of the storage box, two first assembly plates are fixedly connected to the upper parts of the baffles, which are close to one end of the storage box, the first assembly plates are in sliding connection with the inside of the first assembly grooves, two second assembly plates are respectively fixedly connected to the two sides of the baffles, which are close to one end of the storage box, test tube placing plates are fixedly connected to the middle parts of the baffles, which are close to one end of the storage box, and test tube containing plates are fixedly connected to the lower parts of the baffles, which are close to one end of the storage box;
through the technical scheme, the sample pretreatment equipment for the mental drugs can enable the centrifugal seat 18 to be more stable in the high-speed rotation process, is not easy to generate the phenomena of position deviation and shaking, further ensures the stability of the drugs in the centrifugal process, improves the centrifugal quality of the drugs, can simultaneously store the working solution in a classified manner, has strong refrigeration effect and uniform refrigeration effect, simultaneously reduces the influence on other solutions when a worker takes a single group of solutions, ensures the preservation state of other solutions, simultaneously realizes pretreatment detection on mental drug samples, ensures the safety and rationality of treatment drugs, and has reasonable and compact overall structure, high automation degree and convenient practical use of the worker.
Preferably, the mounting panel is kept away from the outer wall fixedly connected with of bottom plate center department one end and is connected the longeron, the equal fixedly connected with electric telescopic handle in middle part of connecting the longeron upper surface, the equal fixedly connected with mounting bracket of output of electric telescopic handle, the middle part fixedly connected with splash guard of mounting bracket upper surface, the middle part fixedly connected with stirring box of mounting bracket lower surface, the middle part fixedly connected with of mounting bracket lower surface one side is first servo motor, the output of first servo motor runs through stirring box and fixedly connected with first dwang, the equal fixedly connected with of outer wall of first dwang is a plurality of stirring leaves.
Preferably, the equal fixedly connected with of both sides of stirring box lower surface is a plurality of first drain pipes, the equal fixedly connected with first liquid level gauge in middle part of first drain pipe, the middle part fixedly connected with second drain pipe of stirring box lower surface, the middle part fixedly connected with second liquid level gauge of second drain pipe, the equal fixedly connected with guide bar of front end and rear end of connection longeron upper surface, the both sides of mounting bracket are all at the outer wall sliding connection of guide bar.
Through above-mentioned technical scheme, can make the mounting bracket more stable in-process that reciprocates through the guide bar, be difficult for the slope.
Preferably, a plurality of installation inclined holes are formed in the upper surface of the test tube rack, a plurality of first elastic confinement sleeves are fixedly connected to the upper surface of the test tube rack, round table sleeves are fixedly connected to the inner parts of the installation inclined holes respectively, second elastic confinement sleeves are fixedly connected to the middle parts of the round table sleeves, and a plurality of weight reduction grooves are formed in the upper surface of the test tube rack.
Preferably, the rear end the equal fixedly connected with hinge block of outer wall of backup pad, the equal hinge connection in middle part of hinge block has the articulated slab, the equal fixedly connected with protection window in upper portion of articulated slab front end outer wall, the front end the equal fixedly connected with of outer wall of backup pad connects the short board, the one end equal fixedly connected with locating plate that is close to centrifugal seat center department on short board upper portion is connected, the arc constant head tank has all been seted up to the upper surface of locating plate, the both sides and the arc constant head tank joint cooperation of protection window front end, the rectangle constant head tank has been seted up on the upper portion of articulated slab rear end outer wall, the middle part fixedly connected with locating frame of connecting seat rear end outer wall, the rectangle constant head tank cooperates with the rear end joint of locating frame.
Through above-mentioned technical scheme, can make the protection window by the joint cooperation by the location at the in-process that does not use, be difficult for rocking from top to bottom.
Preferably, the storage box is fixedly connected with a second handle at one end far away from the center of the storage box.
Preferably, the other side of the outer wall of the sealing door is fixedly connected with a first handle.
Preferably, the front end of the outer wall of the mounting plate on one side is fixedly connected with a control display panel and a PLC controller respectively;
through above-mentioned technical scheme, through PLC controller and control display panel, first servo motor, electric telescopic handle and second servo motor electric connection, can be convenient for the staff to control it.
Advantageous effects
The invention provides sample pretreatment equipment for detecting psychotropic drugs in serum. The beneficial effects are as follows:
compared with the existing sample pretreatment equipment for the psychotropic drugs, the sample pretreatment equipment for the psychotropic drugs can enable the centrifugal seat to be more stable in the high-speed rotation process, is not easy to shift and shake, further guarantees stability of drugs in the centrifugation process, and improves centrifugation quality of the drugs.
Compared with the existing sample pretreatment equipment for the psychotropic drugs, the sample pretreatment equipment for the psychotropic drugs can store working solutions in a classified mode, is high in refrigeration effect and uniform in refrigeration effect, and can reduce the influence on other solutions in the process of taking a single group of solutions by workers, so that the preservation state of the other solutions is guaranteed.
Compared with the existing sample pretreatment equipment for the psychotropic drugs, the sample pretreatment equipment for the psychotropic drugs can realize pretreatment detection of the psychotropic drugs, ensures safety and rationality of treatment and drug administration, and is reasonable and compact in overall structure, high in automation degree and convenient for practical use of staff.
Drawings
FIG. 1 is a schematic view of a forward body structure of the present invention;
FIG. 2 is a schematic view of the reverse main structure of the present invention;
FIG. 3 is a schematic elevational view of the present invention;
FIG. 4 is a schematic structural view of the stirring box of the present invention;
FIG. 5 is a schematic view of the centrifugal base of the present invention;
FIG. 6 is a schematic view of the structure of the connecting seat, the centrifugal seat and the protection window of the present invention;
FIG. 7 is a schematic view of the structure of the connecting seat and the protection window of the present invention;
FIG. 8 is a schematic top view of the centrifuge bowl according to the present invention;
FIG. 9 is a schematic view of a fixing base of the present invention;
FIG. 10 is a schematic view of the structure of the limiting cap, spring, first limiting arc plate and third rotating bead of the present invention;
FIG. 11 is a schematic view of the structure of the first elastic confinement sleeve, the circular table sleeve and the second elastic confinement sleeve of the present invention;
FIG. 12 is a front view of the connecting mount, the centrifugal mount and the protective window of the present invention;
FIG. 13 is a schematic view of the structure of the storage box of the present invention;
FIG. 14 is a schematic view of a storage case according to the present invention;
FIG. 15 is a schematic view of the bottom structure of the case of the present invention;
FIG. 16 is a schematic view of the structure of the storage case and semiconductor refrigerator of the present invention;
FIG. 17 is a schematic view of the structure of the test tube rack and the mounting inclined hole of the present invention.
Wherein, 1, the bottom plate; 2. a mounting plate; 3. connecting long plates; 4. an electric telescopic rod; 5. a guide rod; 6. a mounting frame; 7. a splash guard; 8. a stirring box; 9. a first servo motor; 10. a first rotating lever; 11. stirring the leaves; 12. a first liquid outlet pipe; 13. a first level gauge; 14. a connecting block; 15. a connecting seat; 16. a connecting frame; 17. a second servo motor; 18. a centrifugal seat; 19. a first chute; 20. a second chute; 21. a first rotating bead; 22. a second rotating bead; 23. mounting an inclined hole; 24. a V-shaped mounting plate; 25. a reinforcing column; 26. an arc-shaped fixing groove; 27. a reinforcing block; 28. a connecting column; 29. a rectangular mounting plate; 30. a fixing seat; 31. a test tube placing rack; 32. a weight reduction groove; 33. a first elastic confinement sleeve; 34. a round platform sleeve; 35. a second elastic confinement sleeve; 36. a limit groove; 37. a third chute; 38. a limiting cover; 39. a spring; 40. the first limiting arc plate; 41. a third rotating bead; 42. a support plate; 43. the second limiting arc plate; 44. a fourth rotating bead; 45. a hinge block; 46. a hinged plate; 47. a protective window; 48. connecting short plates; 49. a positioning plate; 50. a positioning frame; 51. a rectangular positioning groove; 52. a storage box; 53. a slide plate; 54. sealing the door; 55. a first handle; 56. a semiconductor refrigerator; 57. a storage box; 58. a fixing groove; 59. a first ventilation slot; 60. a first ventilation rectangular aperture; 61. a second ventilation slot; 62. a second ventilation rectangular hole; 63. a ventilation round hole; 64. a first fitting groove; 65. a second fitting groove; 66. a baffle; 67. a second handle; 68. a first assembly plate; 69. a second assembly plate; 70. a test tube placing plate; 71. a test tube storage plate; 72. controlling a display panel; 73. a PLC controller; 74. a second liquid outlet pipe; 75. a second level gauge; 76. arc-shaped positioning grooves.
Description of the embodiments
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As shown in fig. 1-17, the embodiment of the invention provides sample pretreatment equipment for detecting psychotropic drugs in serum, which comprises a bottom plate 1, wherein mounting plates 2 are fixedly connected to two sides of the upper surface of the bottom plate 1, connecting blocks 14 are fixedly connected to the lower parts of one ends of the mounting plates 2, which are close to the center of the bottom plate 1, connecting seats 15 are fixedly connected to one ends of the connecting blocks 14, which are close to the center of the bottom plate 1, connecting frames 16 are fixedly connected to the middle parts of the lower surfaces of the connecting seats 15, second servo motors 17 are fixedly connected to the middle parts of the inner bottom surfaces of the connecting frames 16, output ends of the second servo motors 17 penetrate through the connecting seats 15 and are fixedly connected with centrifugal seats 18, a first sliding groove 19 and a second sliding groove 20 are respectively formed in the outer walls of the lower ends of the centrifugal seats 18, a plurality of first rotating beads 21 and second rotating beads 22 are respectively connected to the inner walls of the connecting seats 15 in a sliding mode, and the first rotating beads 21 are connected to the inner parts of the first sliding grooves 19 and the second rotating beads 22 are connected to the inner parts of the second sliding grooves 20 in a sliding mode;
the middle part of the inner bottom surface of the centrifugal seat 18 is fixedly connected with two V-shaped mounting plates 24, the adjacent ends of the V-shaped mounting plates 24 are fixedly connected with three reinforcing columns 25, one ends of the V-shaped mounting plates 24, which are far away from the center of the centrifugal seat 18, are fixedly connected with reinforcing blocks 27, the upper surfaces of the reinforcing blocks 27 are respectively fixedly connected with two connecting columns 28, the upper surfaces of the connecting columns 28 are fixedly connected with rectangular mounting plates 29, the upper surfaces of the rectangular mounting plates 29 and the V-shaped mounting plates 24 are fixedly connected with fixing seats 30, the upper surfaces of the fixing seats 30 are provided with arc-shaped fixing grooves 26, and test tube placing racks 31 are fixedly connected inside the arc-shaped fixing grooves 26;
the outer wall of the upper end of the centrifugal seat 18 is respectively provided with a limit groove 36 and a third sliding groove 37, the middle part of one end of the mounting plate 2, which is close to the center of the bottom plate 1, is fixedly connected with a limit cover 38, the inside of the limit cover 38 is fixedly connected with a plurality of springs 39, one end of each spring 39, which is close to the center of the centrifugal seat 18, is fixedly connected with a first limit arc plate 40, the middle part of each first limit arc plate 40 is rotationally connected with a plurality of third rotating beads 41, the third rotating beads 41 are in sliding connection with the inside of the limit groove 36, the two sides of the outer walls of the front end and the rear end of the connecting seat 15 are fixedly connected with a support plate 42, one end of the upper end of the support plate 42, which is close to the center of the centrifugal seat 18, is fixedly connected with a second limit arc plate 43, the middle part of each second limit arc plate 43 is rotationally connected with a fourth rotating bead 44, and the fourth rotating beads 44 are in sliding connection with the inside of the third sliding groove 37;
the middle part of the upper surface of the bottom plate 1 is fixedly connected with a storage box 52, the middle parts of the outer walls of two sides of the storage box 52 are respectively fixedly connected with three semiconductor refrigerators 56, two storage boxes 57 are arranged in the storage box 52, the lower surface of each storage box 57 and the outer walls of the two sides are provided with first ventilation grooves 59, one end of each first ventilation groove 59, which is close to the center of each storage box 57, is provided with a plurality of first ventilation rectangular holes 60, the outer wall of one end of each storage box 57, which is close to the center of each storage box 52, is provided with a plurality of second ventilation rectangular holes 62, one end of each second ventilation groove 61, which is close to the center of each storage box 52, is provided with a plurality of ventilation round holes 63, the inner bottom surface of each storage box 52 is fixedly connected with three sliding plates 53, the lower surface of each storage box 57 is provided with three fixing grooves 58, each fixing groove 58 is connected with the outer walls of each sliding plates 53 in a sliding mode, and one side of the front end and the rear end of each storage box 52 is hinged with a sealing door 54;
two first assembly grooves 64 are respectively formed in two sides of the inner top surface of the storage box 57, second assembly grooves 65 are respectively formed in the upper ends and the lower ends of the inner walls of the two sides of the storage box 57, baffle plates 66 are respectively arranged on two sides of the storage box 57, two first assembly plates 68 are fixedly connected to the upper part of one end of the baffle plates 66, which is close to the storage box 57, the first assembly plates 68 are respectively connected with two second assembly plates 69 in a sliding mode in the first assembly grooves 64, two sides of one end of the baffle plates 66, which are close to the storage box 57, are respectively connected with two second assembly plates 69 in a sliding mode in the second assembly grooves 65, test tube placing plates 70 are fixedly connected to the middle part of one end of the baffle plates 66, which is close to the storage box 57, and test tube containing plates 71 are fixedly connected to the lower part of the one end of the baffle plates 66, which is close to the storage box 57;
the sample pretreatment equipment for the mental drugs can enable the centrifugal seat 18 to be more stable in the high-speed rotation process, is not easy to generate the phenomena of position deviation and shaking, further ensures the stability of the drugs in the centrifugation process, improves the centrifugation quality of the drugs, can simultaneously store working solutions in a classified manner, has strong refrigeration effect and uniform refrigeration effect, simultaneously reduces the influence on other solutions when workers take a single group of solutions, ensures the preservation state of other solutions, simultaneously realizes pretreatment detection on mental drug samples, ensures the safety and rationality of treatment drugs, and has reasonable and compact overall structure, high automation degree and convenient practical use of the workers.
The mounting panel 2 is kept away from outer wall fixedly connected with of bottom plate 1 center department one end and is connected longeron 3, the equal fixedly connected with electric telescopic handle 4 in middle part of connecting longeron 3 upper surface, the equal fixedly connected with mounting bracket 6 of output of electric telescopic handle 4, the middle part fixedly connected with splash guard 7 of mounting bracket 6 upper surface, the middle part fixedly connected with stirring box 8 of mounting bracket 6 lower surface, the middle part fixedly connected with of mounting bracket 6 lower surface one side is first servo motor 9, the output of first servo motor 9 runs through stirring box 8 and fixedly connected with first dwang 10, the equal fixedly connected with of outer wall of first dwang 10 is a plurality of stirring leaf 11.
A plurality of first liquid outlet pipes 12 are fixedly connected to two sides of the lower surface of the stirring box 8, a first liquid level meter 13 is fixedly connected to the middle of each first liquid outlet pipe 12, a second liquid outlet pipe 74 is fixedly connected to the middle of the lower surface of the stirring box 8, a second liquid level meter 75 is fixedly connected to the middle of each second liquid outlet pipe 74, a guide rod 5 is fixedly connected to the front end and the rear end of the upper surface of the connecting long plate 3, and two sides of the mounting frame 6 are slidably connected to the outer wall of the guide rod 5;
the guide rod 5 can enable the mounting frame 6 to be more stable in the process of moving up and down, and is not easy to incline.
The upper surface of test tube rack 31 has all seted up a plurality of installation inclined holes 23, and the upper surface of test tube rack 31 is all fixedly connected with a plurality of first elasticity confinement cover 33, and the inside of installation inclined hole 23 is fixedly connected with round platform sleeve 34 respectively, and the equal fixedly connected with second elasticity confinement cover 35 in the middle part of round platform sleeve 34, a plurality of weight-reducing grooves 32 have all been seted up to the upper surface of test tube rack 31.
The outer wall of rear end backup pad 42 all fixedly connected with hinge block 45, the middle part of hinge block 45 all articulates and is connected with hinged plate 46, the upper portion of hinged plate 46 front end outer wall all fixedly connected with guard window 47, the outer wall of front end backup pad 42 all fixedly connected with connect the short board 48, the one end that is close to centrifugal seat 18 center department on the upper portion of connecting the short board 48 all fixedly connected with locating plate 49, arc constant head tank 76 has all been seted up to the upper surface of locating plate 49, the both sides and the arc constant head tank 76 joint cooperation of guard window 47 front end, rectangular constant head tank 51 has been seted up to the upper portion of hinged plate 46 rear end outer wall, the middle part fixedly connected with locating frame 50 of connecting seat 15 rear end outer wall, rectangular constant head tank 51 and the rear end joint cooperation of locating frame 50.
The protection window 47 can be positioned in the process of not using by the clamping fit, and is not easy to shake up and down.
The ends of the storage boxes 57 away from the center of the storage box 52 are each fixedly connected with a second handle 67.
The other side of the outer wall of the sealing door 54 is fixedly connected with a first handle 55.
The front end of the outer wall of the one-side mounting plate 2 is fixedly connected with a control display panel 72 and a PLC 73 respectively;
the PLC 73 is electrically connected with the control display panel 72, the first servo motor 9, the electric telescopic rod 4 and the second servo motor 17, so that a worker can conveniently control the electric telescopic rod.
Working principle: the sample pretreatment apparatus starts the first servo motor 9 to drive the stirring blade 11 to rotate, further the object to be tested in the stirring box 8 is stirred in real time, the object to be tested is fully mixed with the dissolution liquid, then the test tubes are placed in the test tube placing frame 31 in sequence, the mounting frame 6 moves towards the direction of the centrifugal base 18 by starting the electric telescopic rod 4, when the first liquid outlet pipe 12 and the second liquid outlet pipe 74 enter the upper end of the test tube, the solution in the stirring box 8 can enter the test tube accurately and quantitatively by the first liquid level gauge 13 and the second liquid level gauge 75, the first liquid outlet pipe 12 and the second liquid outlet pipe 74 move upwards by starting the electric telescopic rod 4, the centrifugal base 18 and the test tube placing frame 31 are started to rotate by starting the second servo motor 17, at the moment, the test tube without the solution is rotated to the position right below the first liquid outlet pipe 12, the electric telescopic rod 4 is started to enable the first liquid outlet pipe 12 to enter the upper end of the test tube again, the first liquid level meter 13 enables the solution in the stirring box 8 to enter the test tube accurately, the solution is sequentially injected into the test tube, the purpose of injecting the solution into a plurality of test tubes is achieved, manual liquid injection of workers is avoided, liquid injection efficiency is effectively improved, meanwhile, artificial pollution to the solution is reduced, when all the test tubes are injected completely, the protection window 47 can be enabled to turn round through the rotation hinge plate 46 and be supported and limited by the connection short plate 48 and the positioning groove 76, the second servo motor 17 is started to rotate at a high speed, at the moment, the test tubes in the test tube placing frame 31 start to rotate at a high speed, in the process of rotating the centrifugal seat 18 at a high speed, the first rotating beads 21 slide in the first sliding groove 19, the second rotating beads 22 slide in the second sliding groove 20, the centrifugal seat 18 can be ensured to be more stable in the high-speed rotation process, the third rotating bead 41 and the limiting groove 36 can be in sliding connection under the action of the spring 39 and the first limiting arc plate 40, and vibration and noise generated in the working process of the centrifugal seat 18 can be reduced under the action of the spring 39, so that the stability and the safety of equipment are improved, cold air can sequentially enter the storage box 57 through the first ventilating groove 59, the first ventilating rectangular hole 60, the second ventilating groove 61, the second ventilating rectangular hole 62 and the ventilating round hole 63 by starting the semiconductor refrigerator 56, the high-efficiency refrigeration of the storage box 57 is achieved, the uniform coverage of the cold air to the inside of the storage box 57 is effectively improved, the phenomenon that a worker is difficult to deteriorate and damage the solution in the long-term storage process of the working solution is avoided, meanwhile, when the worker needs to take the solution in the storage box 57, the corresponding baffle 66, the test tube storage plate 71 and the placing plate 70 are pulled out of the storage box 52 only through opening the corresponding second handle 67, the cold air loss inside the storage box 52 is effectively reduced, and other external air loss conditions of the storage box 52 are also guaranteed, and other external storage problems are solved.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. Sample pretreatment equipment for detecting psychotropic drugs in serum, which comprises a bottom plate (1), and is characterized in that: the two sides of the upper surface of the bottom plate (1) are fixedly connected with a mounting plate (2), the lower part of one end, close to the center of the bottom plate (1), of the mounting plate (2) is fixedly connected with a connecting block (14), one end, close to the center of the bottom plate (1), of the connecting block (14) is fixedly connected with a connecting seat (15), the middle part of the lower surface of the connecting seat (15) is fixedly connected with a connecting frame (16), the middle part of the inner bottom surface of the connecting frame (16) is fixedly connected with a second servo motor (17), the output end of the second servo motor (17) penetrates through the connecting seat (15) and is fixedly connected with a centrifugal seat (18), a first sliding groove (19) and a second sliding groove (20) are respectively formed in the outer wall of the lower end of the centrifugal seat (18), the inner wall of the connecting seat (15) is respectively connected with a plurality of first rotating beads (21) and second rotating beads (22), the first rotating beads (21) are in sliding connection in the inner part of the first sliding groove (19), and the second rotating beads (22) are in sliding connection in the inner part of the second sliding groove (20).
Two V-shaped mounting plates (24) are fixedly connected to the middle of the inner bottom surface of the centrifugal seat (18), three reinforcing columns (25) are fixedly connected to adjacent ends of the V-shaped mounting plates (24), reinforcing blocks (27) are fixedly connected to one ends, away from the center of the centrifugal seat (18), of the V-shaped mounting plates (24), two connecting columns (28) are fixedly connected to the upper surfaces of the reinforcing blocks (27) respectively, rectangular mounting plates (29) are fixedly connected to the upper surfaces of the connecting columns (28), fixing seats (30) are fixedly connected to the upper surfaces of the rectangular mounting plates (29) and the V-shaped mounting plates (24), arc-shaped fixing grooves (26) are formed in the upper surfaces of the fixing seats (30), and test tube placing frames (31) are fixedly connected to the inner parts of the arc-shaped fixing grooves (26);
the outer wall of the upper end of the centrifugal seat (18) is respectively provided with a limit groove (36) and a third sliding groove (37), the middle parts of the end, close to the center of the bottom plate (1), of the mounting plate (2) are fixedly connected with a limit cover (38), the inside of the limit cover (38) is fixedly connected with a plurality of springs (39), one end, close to the center of the centrifugal seat (18), of each spring (39) is fixedly connected with a first limit arc plate (40), the middle parts of the first limit arc plates (40) are respectively connected with a plurality of third rotating beads (41) in a rotating mode, the third rotating beads (41) are respectively connected in a sliding mode in the limit grooves (36), two sides of the outer walls of the front end and the rear end of the connecting seat (15) are respectively fixedly connected with a support plate (42), one end, close to the center of the upper end of the support plate (42), of each support plate (18) is respectively fixedly connected with a second limit arc plate (43), the middle parts of the second limit arc plates (43) are respectively connected with a fourth rotating bead (44), and the fourth rotating beads (44) are respectively in the inner sliding mode in the third sliding grooves (37);
the middle part fixedly connected with storage box (52) of bottom plate (1) upper surface, the middle part of storage box (52) both sides outer wall is fixedly connected with three semiconductor refrigerator (56) respectively, the inside of storage box (52) is provided with two storage boxes (57), first ventilation slot (59) have all been seted up to the outer wall of lower surface and both sides of storage box (57), a plurality of first ventilation rectangular holes (60) have all been seted up to the one end that first ventilation slot (59) is close to storage box (57) center department, second ventilation slot (61) have all been seted up to the outer wall that storage box (57) is close to storage box (52) center department one end, a plurality of second ventilation rectangular holes (62) have all been seted up to the both sides of second ventilation slot (61), a plurality of ventilation round holes (63) have all been seted up to the one end that storage box (57) is close to storage box (52) center department, three slide (53) are all fixedly connected with in the inner bottom surface of storage box (52), three fixed slot (58) have all been seted up on the lower surface of storage box (57) and all been connected with sliding door (53) in front of the sealed door (54);
two first assembly grooves (64) have been seted up respectively to the both sides of roof surface in storage box (57), second assembly groove (65) have been seted up respectively to the upper end and the lower extreme of storage box (57) both sides inner wall, the both sides of storage box (57) are provided with baffle (66) respectively, baffle (66) are close to the equal fixedly connected with two first assembly plates (68) in upper portion of storage box (57) one end, first assembly plate (68) all are in the inside sliding connection of first assembly groove (64), baffle (66) are close to the both sides of storage box (57) one end and are fixedly connected with two second assembly plates (69) respectively, second assembly plate (69) all are in the inside sliding connection of second assembly groove (65), the middle part that baffle (66) are close to storage box (57) one end is fixedly connected with test tube placement plate (70), the lower part that baffle (66) are close to storage box (57) one end is fixedly connected with test tube storage plate (71).
2. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 1, wherein: the utility model discloses a motor-driven electric motor stirring device, including mounting panel (2), connecting longeron (3), motor-driven telescopic handle (4) of equal fixedly connected with in middle part of connecting longeron (3) upper surface, the equal fixedly connected with mounting bracket (6) of output of motor-driven telescopic handle (4), the middle part fixedly connected with splash guard (7) of mounting bracket (6) upper surface, the middle part fixedly connected with stirring box (8) of mounting bracket (6) lower surface, the middle part fixedly connected with first servo motor (9) of mounting bracket (6) lower surface one side, the output of first servo motor (9) runs through stirring box (8) and fixedly connected with first dwang (10), the equal fixedly connected with of outer wall of first dwang (10) a plurality of stirring leaves (11).
3. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 2, wherein: the stirring box comprises a stirring box body and is characterized in that two sides of the lower surface of the stirring box body are fixedly connected with a plurality of first liquid outlet pipes (12), the middle of each first liquid outlet pipe (12) is fixedly connected with a first liquid level meter (13), the middle of the lower surface of the stirring box body is fixedly connected with a second liquid outlet pipe (74), the middle of each second liquid outlet pipe (74) is fixedly connected with a second liquid level meter (75), the front end and the rear end of the upper surface of a long connecting plate (3) are fixedly connected with guide rods (5), and two sides of each mounting frame (6) are slidably connected with the outer walls of the guide rods (5).
4. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 1, wherein: the upper surface of test tube rack (31) has all seted up a plurality of installation inclined holes (23), the upper surface of test tube rack (31) is a plurality of first elasticity confinement cover (33) of all fixedly connected with, the inside of installation inclined hole (23) is fixedly connected with round platform sleeve (34) respectively, the equal fixedly connected with second elasticity confinement cover (35) in middle part of round platform sleeve (34), a plurality of weight-reduction groove (32) have all been seted up to the upper surface of test tube rack (31).
5. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 1, wherein: the rear end the equal fixedly connected with hinge block (45) of outer wall of backup pad (42), the middle part of hinge block (45) all articulates and is connected with hinged plate (46), the equal fixedly connected with protection window (47) in upper portion of hinge plate (46) front end outer wall, the front end the equal fixedly connected with of outer wall of backup pad (42) is connected with short board (48), the one end that is close to centrifugal seat (18) center department on short board (48) upper portion is equal fixedly connected with locating plate (49), arc constant head tank (76) have all been seted up to the upper surface of locating plate (49), rectangle constant head tank (51) have been seted up on the upper portion of hinged plate (46) rear end outer wall, the middle part fixedly connected with locating frame (50) of connecting seat (15) rear end outer wall, rectangle constant head tank (51) and the rear end joint cooperation of locating frame (50).
6. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 1, wherein: and one end of the storage box (57) far away from the center of the storage box (52) is fixedly connected with a second handle (67).
7. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 1, wherein: the other side of the outer wall of the sealing door (54) is fixedly connected with a first handle (55).
8. A sample pretreatment apparatus for detecting psychotropic drugs in serum according to claim 1, wherein: the front end of the outer wall of the mounting plate (2) on one side is fixedly connected with a control display panel (72) and a PLC (programmable logic controller) 73 respectively.
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| CN202311777595.7A CN117451463B (en) | 2023-12-22 | 2023-12-22 | Sample pretreatment equipment for detecting psychotropic drugs in serum |
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| CN202311777595.7A CN117451463B (en) | 2023-12-22 | 2023-12-22 | Sample pretreatment equipment for detecting psychotropic drugs in serum |
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