CN117426766A - Multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram - Google Patents
Multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram Download PDFInfo
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- CN117426766A CN117426766A CN202311621585.4A CN202311621585A CN117426766A CN 117426766 A CN117426766 A CN 117426766A CN 202311621585 A CN202311621585 A CN 202311621585A CN 117426766 A CN117426766 A CN 117426766A
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Abstract
The invention provides a multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram, belonging to the field of human brain medical diagnosis equipment. The system comprises a data processing and displaying module, an MR spectrometer, an MR enabling switch, an MR pre-amplifier, an EEG enabling switch, an EEG signal amplifier, an EEG acquisition module and a sensor module; the sensor module is in a hat shape and sequentially comprises an MR transmitting coil, a non-contact multichannel EEG probe and a multichannel MR receiving coil from outside to inside; a non-contact multichannel EEG probe arranged on a flexible circuit board; the MR spectrometer is connected to the MR-enabled switch and the EEG-enabled switch, and the EEG is open and in an off state when the MR-enabled switch is closed and the EEG is open and in an off state when the EEG-enabled switch is closed. The invention integrates MR and EEG in the same system, and MR/EEG signal acquisition is not interfered with each other, thus realizing multi-mode imaging of the integrated system and enhancing the accuracy of imaging disease diagnosis.
Description
Technical Field
The invention belongs to the field of brain monitoring equipment, and particularly relates to a multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram.
Background
Significant breakthroughs in modern medicine are increasingly dependent on advanced technical means and instrumentation. Monitoring of brain function in humans, including Electroencephalogram (EEG) and magnetic resonance imaging (Magnetic Resonance Imaging, MRI), and the like. The EEG is a graph obtained by amplifying and recording spontaneous bioelectric potential of a brain from a scalp through a precise electronic sensor, is spontaneous and rhythmic electric activity of a brain cell group recorded through an electrode, has the characteristics of portability, non-invasiveness and the like as an electrophysiological monitoring method for recording the brain electric activity, is clinically used for diagnosing epilepsy, stroke, brain injury, brain tumor and the like, and can be used for determining the change of the brain activity in aspects of sleep disorder, anesthesia depth, brain dysfunction and the like, but cannot provide structural information of the brain. MRI can provide structural and functional information of the brain, where functional magnetic resonance imaging (fMRI) measures brain activity by detecting changes associated with blood flow based on brain blood flow and neuronal activity correlation, primarily for human or animal brain activity monitoring. MRI can reflect brain structure more accurately, but it does not "truly" follow millisecond brain function changes, diagnosing brain functional disorders, and electroencephalogram (EEG) can make up for this deficiency. Therefore, MRI is used in combination with EEG, and physiological activity and changes of the brain can be monitored together, reflecting the state of brain function.
In the prior art, EEG monitors the electrical activity of brain cell populations, including both contact and non-contact. The brain electrical signals are collected by contact with the scalp of the human brain. The 'contact' requirement is that the electrodes must be arranged on the scalp, the arrangement process of the electrodes outside the human brain is time-consuming and labor-consuming, the requirement on the professionality is high, the instability or inaccuracy of measurement is easily caused by poor electrode falling or contact, and the comfort level of the patient is reduced. When integrated with an MRI apparatus, the requirement that the contact EEG probe is located inside the MR imaging receiving coil reduces the detection sensitivity of the MR and also restricts the integration of the contact EEG probe and the MR imaging probe. And the non-contact EEG adopts a capacitive coupling mode to collect the EEG signals, and the non-contact EEG probe can be arranged outside an MRI receiving coil, so that fusion with MRI equipment can be realized. Simultaneously provides MR and EEG signals, and realizes comprehensive monitoring of brain functions.
Disclosure of Invention
In view of the above-mentioned drawbacks or shortcomings in the prior art, the present invention aims to provide a multi-modality imaging system for craniocerebral magnetic resonance and electroencephalogram, which integrates an MR electronic element and an EEG electronic element to realize fusion of MRI and EEG, and a non-contact EEG probe and an MRI probe do not interfere with each other to realize integration of the multi-modality system, enhance accuracy of diagnosis of MR imaging diseases, and expand diagnostic capability in brain functional diseases.
In order to achieve the above purpose, the embodiment of the present invention adopts the following technical scheme:
a multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram comprises a data processing and displaying module, an MR spectrometer, an MR enabling switch, an MR preamplifier, an EEG enabling switch, an EEG signal amplifier, an EEG acquisition module and a sensor module;
the sensor module is in a hat shape in appearance and sequentially comprises an MR transmitting coil, a non-contact multichannel EEG probe and a multichannel MR receiving coil from outside to inside.
As a preferred embodiment of the invention, the non-contact multi-channel EEG probe comprises several circular capacitive coupled probes of 3-4cm diameter arranged on a flexible circuit board, several capacitive coupled probes integrated with a multi-channel MR receive coil into a cap shape with a common center.
As a preferred embodiment of the invention, the MR spectrometer is connected to an MR-enabled switch and an EEG-enabled switch; when the MR enabling switch is closed, the EEG enabling switch is opened, and the EEG is in a disconnected state and cannot be monitored, the multichannel MR receiving coil receives MR signals, and structural and functional monitoring is carried out on the brain in the hat shape; when the EEG enabling switch is closed, the MR enabling switch is opened, the MR coil is in a disconnected state, MR signal monitoring cannot be carried out, and the non-contact multichannel EEG probe acquires an EEG.
As a preferred embodiment of the present invention, the multi-channel MR receiving coil includes two types, i.e., a high-field multi-channel MR receiving coil and a low-field multi-channel MR receiving coil, wherein the high-field multi-channel MR receiving coil is used for a scenario with a nuclear magnetic field strength not lower than 1.5T, and the low-field multi-channel MR receiving coil is used for a scenario with a nuclear magnetic field strength lower than 1.5T, such as a 0.15T shift type magnetic resonance system.
As a preferred embodiment of the present invention, the low-field multi-channel MR receiving coil includes a solenoid coil along the cross-sectional direction and a saddle coil along the central axis direction, and after being combined with the multi-channel EEG probe, the EEG probe is covered outside the combined receiving coil, and the combined receiving coil have no contact, and the external leads are respectively connected with the EEG enabling switch and the MR enabling switch.
As a preferred embodiment of the invention, the high-field multichannel MR receiving coil is a coil array, and after being combined with the multichannel EEG probe, the EEG probe is covered outside the receiving coil array, and the receiving coil array have no contact, and the external leads are respectively connected with an EEG enabling switch and an MR enabling switch.
The technical scheme provided by the embodiment of the invention has the following beneficial effects:
the embodiment of the invention provides a multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram, which comprises a data processing and displaying module, an MR spectrometer, an MR enabling switch, an MR preamplifier, an EEG enabling switch, an EEG signal amplifier, an EEG acquisition module and a sensor module; the sensor module is in a hat shape and sequentially comprises an MR transmitting coil, a non-contact multichannel EEG probe and a multichannel MR receiving coil from outside to inside; the data processing and display module sends commands to the MR spectrometer to control the operation of the MR coil and the EEG probe, and the MR monitoring and the EEG monitoring are not interfered with each other while the two monitoring systems are integrated in the same module. The invention realizes the multi-mode imaging of the integrated system, the MR/EEG signal acquisition processes are independently carried out and do not affect each other, the accuracy of imaging disease diagnosis is enhanced, and the invention is beneficial to confirming signal sources of disease attacks such as epilepsy (namely brain abnormal areas); EEG can also be used as an auxiliary tool to work simultaneously with MR signal acquisition, and environmental noise during MR work is acquired, and is used as an environmental noise acquisition device, and the noise in MR signals is removed by combining a data processing method, so that the image quality of MR is improved.
Of course, it is not necessary for any one product or method of practicing the invention to achieve all of the advantages set forth above at the same time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person of ordinary skill in the art.
FIG. 1 is a schematic diagram of a multi-modality imaging system for brain magnetic resonance and electroencephalogram provided by an embodiment of the present invention;
FIG. 2 is a schematic illustration of the multi-channel EEG probe configuration of FIG. 1;
FIG. 3 is a schematic diagram of the low field multi-channel MR receive coil structure of FIG. 1;
FIG. 4 is a schematic diagram of the structure of the multi-channel EEG probe and low field multi-channel MR receive coil of FIGS. 2 and 3 after integration;
FIG. 5 is a schematic diagram of the structure of the high field multi-channel MR receive coil of FIG. 1;
fig. 6 is a schematic diagram of the structure of the multi-channel EEG probe and high field multi-channel MR receive coil of fig. 2 and 5 after integration.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. It should be noted that, in the case of no conflict, the embodiments of the present invention and features in the embodiments may also be combined with each other.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures. In the description of the present invention, the terms "first," "second," "third," "fourth," and the like are used merely to distinguish between descriptions and are not to be construed as indicating or implying relative importance.
The invention provides a multi-mode imaging system for craniocerebral magnetic resonance and electroencephalogram. As shown in fig. 1, the multi-modal imaging system of craniocerebral magnetic resonance and electroencephalogram comprises a data processing and display module, an MR spectrometer, an MR enabling switch, an MR preamplifier, an EEG enabling switch, an EEG signal amplifier, an EEG acquisition module and a sensor module; the sensor module is in a hat shape and sequentially comprises an MR transmitting coil, a non-contact multichannel EEG probe and a multichannel MR receiving coil from outside to inside.
As shown in fig. 2, the non-contact multi-channel EEG probe comprises several circular capacitive coupling probes with a diameter of 3-4cm, arranged on a flexible circuit board, integrated with a multi-channel MR receive coil into a cap shape with a common center.
The MR spectrometer, the MR enabling switch, the MR pre-amplifier, the MR transmitting coil in the sensor module and the multichannel MR receiving coil jointly form an MR imaging system. The MR imaging system comprises the necessary hardware elements, as well as other necessary elements such as a magnet, a gradient power amplifier, a gradient coil, a radio frequency power amplifier and the like. The magnets, gradient power amplifiers, gradient coils, etc. are conventional accessories of MR imaging systems and are not described in detail here. In this embodiment, the MR spectrometer is further connected to the EEG acquisition system and the EEG enabling switch, and is configured to control on/off of the EEG acquisition system, so as to perform cooperative or independent operation with the MR imaging system, so that the acquisition of MR signals and the acquisition of EEG signals do not interfere with each other.
In particular, MR spectrometers in MR imaging systems are used to implement timing control, analog signal digitizing and communication with data processing and display modules. The magnet generates a static magnetic field B0, so that hydrogen nuclei in the brain in the static magnetic field B0 are polarized to have a net magnetic moment M0; after the transmission pulse of the MR spectrometer is amplified by a radio frequency power amplifier, the transmission pulse is applied to a transmission coil, a generated radio frequency magnetic field B1 twists a net magnetic moment M0 by a certain angle, and the twisted hydrogen atomic nucleus generates an electromagnetic wave signal when returning to an initial state; the gradient pulse is amplified by a gradient power amplifier and then applied to a gradient coil, so that MR signal space coding is realized; the receiving coil receives the encoded MR signals, the MR spectrometer converts the analog signals into digital signals after amplification by the preamplifier, and then the digital signals are uploaded to the data processing and display module. In this embodiment, general MR hardware such as a magnet, a gradient power amplifier, a gradient coil, a radio frequency power amplifier, etc. belongs to the conventional arrangement of the MR system, and will not be described here again.
The MR spectrometer is connected with the MR enabling switch and the EEG enabling switch; when the MR enabling switch is closed, the EEG enabling switch is opened, and the EEG is in a disconnected state and cannot be monitored, the multichannel MR receiving coil receives MR signals, and structural and functional monitoring is carried out on the brain in the hat shape; when the EEG enabling switch is closed, the MR enabling switch is opened, at the moment, the MR coil is in a disconnected state, MR signal monitoring cannot be carried out, but the EEG acquires bioelectric signals of the brain in a non-contact mode, and the bioelectric signals are amplified by the signal amplifier and then transmitted to the EEG acquisition system, and finally the bioelectric signals are uploaded to the data processing and display module.
In one application example, when the EEG enabling switch is turned on, the non-contact multi-channel EEG probe can be connected to the MR imaging system through another circuit path, and the multi-channel EEG probe is an auxiliary tool of the MR imaging system, collects noise in the MR environment, and transmits the generated signals together with the MR signals to the data processing and displaying module through the MR preamplifier and is used for refining the MR signals to obtain more accurate MR data.
The multichannel MR receiving coil comprises a high field and a low field, wherein the high field multichannel MR receiving coil is used for scenes with magnetic field intensity not lower than 1.5T, and the low field multichannel MR receiving coil is used for scenes with magnetic field intensity lower than 1.5T or lower.
As shown in fig. 3 and 4, the low-field multi-channel MR receiving coil includes a solenoid coil along the cross-sectional direction and a saddle coil along the central axis direction, and after the multi-channel EEG probe shown in fig. 2 is combined, the EEG probe is covered outside the combined coil, and no contact exists between the combined coil and the combined coil, and the external lead wires are respectively connected with the EEG enabling switch and the MR enabling switch.
As shown in fig. 5 and 6, the high-field multi-channel MR receiving coil is a coil array, and after being combined with the multi-channel EEG probe shown in fig. 2, the EEG probe is covered outside the coil array, and the two are free of any contact, and the external lead wires are respectively connected with the EEG enabling switch and the MR enabling switch.
When the brain function diagnosis is carried out by adopting the multi-mode imaging system of craniocerebral magnetic resonance and electroencephalogram provided by the embodiment of the invention, after the MR spectrometer is opened by the monitoring controller, the MR spectrometer is controlled to be connected with the MR enabling switch and closed, and at the moment, the EEG probe is in an open state and no signal is input; the MR spectrometer transmits radio frequency pulses through the MR transmitting coil, the multichannel MR receiving coil receives signals of brain MR, and the signals are amplified through the MR preamplifier and then transmitted back to the MR spectrometer, and finally transmitted to the data processing and displaying module. When EEG acquisition is needed, the monitoring controller commands the MR spectrometer to close the EEG enabling switch, and the MR coil is in an open state at the moment, and no MR signal is input; the multichannel EEG probe starts working, and the bioelectric signals of the brain are acquired and transmitted to an EEG acquisition system through an EEG signal amplifier and finally uploaded to a data processing and display module. The data processing and displaying module processes the MR signal and EEG signal to conduct the physiological and pathological analysis.
According to the technical scheme, the multi-mode imaging system of craniocerebral magnetic resonance and electroencephalogram provided by the embodiment of the invention controls the MR coil and the EEG probe through the MR spectrometer, and the MR system and the EEG system are not interfered with each other while two diagnosis systems are integrated in the same module, so that the multi-mode imaging of the integrated system is realized, and the accuracy of imaging disease diagnosis is enhanced.
The above description is only of the preferred embodiments of the present invention and the description of the technical principles applied is not intended to limit the scope of the invention as claimed, but merely represents the preferred embodiments of the present invention. It will be appreciated by persons skilled in the art that the scope of the invention referred to in the present invention is not limited to the specific combinations of the technical features described above, but also covers other technical features formed by any combination of the technical features described above or their equivalents without departing from the inventive concept. All other embodiments, which can be made by a person skilled in the art without making any inventive effort, are intended to be within the scope of the present invention.
Claims (6)
1. A multi-modal imaging system of craniocerebral magnetic resonance and electroencephalogram, characterized in that the system comprises a data processing and display module, a magnetic resonance MR spectrometer, an MR enabling switch, an MR preamplifier, an electroencephalogram EEG enabling switch, an EEG signal amplifier, an EEG acquisition module and a sensor module;
the sensor module is in a hat shape and sequentially comprises an MR transmitting coil, a non-contact multichannel EEG probe and a multichannel MR receiving coil from outside to inside.
2. The multi-modality imaging system of craniocerebral magnetic resonance and electroencephalogram as claimed in claim 1, wherein the non-contact multi-channel EEG probe comprises several circular capacitive coupled probes of 3-4cm diameter arranged on a flexible circuit board, several capacitive coupled probes integrated into a cap shape having a common center with the multi-channel MR receive coil.
3. The multi-modality imaging system of craniocerebral magnetic resonance and electroencephalogram as claimed in claim 1 wherein the MR spectrometer is connected to an MR-enabled switch and an EEG-enabled switch; when the MR enabling switch is closed, the EEG enabling switch is opened, and the EEG is in a disconnected state and cannot be monitored, the multichannel MR receiving coil receives MR signals, and structural and functional monitoring is carried out on the brain in the hat shape; when the EEG enabling switch is closed, the MR enabling switch is opened, the MR coil is in a disconnected state, MR signal monitoring cannot be carried out, and the non-contact multichannel EEG probe acquires an EEG.
4. The multi-modality imaging system of craniocerebral magnetic resonance and electroencephalogram as claimed in any one of claims 1 to 3, wherein the multi-channel MR receive coil comprises both a high field and a low field, wherein the high field multi-channel MR receive coil is used for scenes with nuclear magnetic field strength not less than 1.5T and the low field multi-channel MR receive coil is used for scenes with nuclear magnetic field strength less than 1.5T.
5. The multi-modality imaging system of craniocerebral magnetic resonance and electroencephalogram as claimed in claim 4, wherein the low-field multi-channel MR receive coil comprises a helical coil in the cross-sectional direction and a saddle-shaped coil in the central axis direction, and when combined with the multi-channel EEG probe, the EEG probe is covered outside the combined coil without any contact, and the external leads are connected to the EEG and MR enable switches, respectively.
6. The multi-modality imaging system of craniocerebral magnetic resonance and electroencephalogram as claimed in claim 4, wherein the high field multi-channel MR receive coil is a coil array, and the EEG probe is covered outside the coil array after being combined with the multi-channel EEG probe, and the external leads are connected with the EEG enable switch and the MR enable switch, respectively, without any contact therebetween.
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