CN117413827A - Suspension containing topramezone and preparation method and application thereof - Google Patents

Suspension containing topramezone and preparation method and application thereof Download PDF

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Publication number
CN117413827A
CN117413827A CN202311462804.9A CN202311462804A CN117413827A CN 117413827 A CN117413827 A CN 117413827A CN 202311462804 A CN202311462804 A CN 202311462804A CN 117413827 A CN117413827 A CN 117413827A
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Prior art keywords
topramezone
agent
suspension
application
water
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Inventor
刘跃怡
崔晶
杨冬梅
张冰
纪文杰
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Jilin Jinqiu Pesticide Co ltd
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Jilin Jinqiu Pesticide Co ltd
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Priority to CN202311462804.9A priority Critical patent/CN117413827A/en
Publication of CN117413827A publication Critical patent/CN117413827A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G13/00—Protecting plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P13/00—Herbicides; Algicides

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to the technical field of pesticides, in particular to a topramezone-containing suspending agent and a preparation method and application thereof. The suspending agent comprises: 20-40wt% of topramezone raw material, 3-5wt% of dispersing agent, 2-3wt% of wetting agent, 0.05-0.2wt% of defoaming agent, 0.08-1.2wt% of inorganic salt, 0.9-1.3wt% of thickening agent, 0-0.5wt% of other auxiliary materials and the balance of water. The topramezone-containing suspending agent has the advantages of excellent stability and long effective time of effective components.

Description

Suspension containing topramezone and preparation method and application thereof
Technical Field
The invention relates to the technical field of pesticides, in particular to a topramezone-containing suspending agent and a preparation method and application thereof.
Background
The chemical name of the topramezone is 4- [3- (4, 5-dihydro-isoxazol-3-yl) -2-methyl-4-methylsulfonyl ] -1-methyl-5-hydroxy-1H-pyrazole, belongs to a p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, and can effectively prevent and kill gramineae and broadleaf weeds in corn fields.
The water-based suspending agent has good environmental protection, but because the topramezone has strong hydrophilicity, the topramezone has larger solubility in water, and the common dispersing agent is easy to desorb from the surface of the original medicine, thereby losing the function, meanwhile, the problems of particle growth or effective ingredient crystallization can occur in the long-term storage process, and the effective time of the medicine is lower when the topramezone suspending agent is used.
Disclosure of Invention
The invention aims to provide a novel topramezone-containing suspending agent, a preparation method and application thereof. The topramezone-containing suspending agent has excellent stability.
In order to achieve the above object, the first aspect of the present invention provides a topramezone-containing suspension, wherein the suspension comprises, in mass percent: 20-40wt% of topramezone raw material, 3-5wt% of dispersing agent, 2-3wt% of wetting agent, 0.05-0.2wt% of defoaming agent, 0.08-1.2wt% of inorganic salt, 0.9-1.3wt% of thickening agent, 0-0.5wt% of other auxiliary materials and the balance of water.
The second aspect of the invention provides a preparation method of the topramezone-containing suspending agent, which comprises the following steps: the dispersion material containing topramezone raw material, dispersing agent, wetting agent, defoaming agent, inorganic salt, other auxiliary materials and water is subjected to at least one-time grinding, and then added with thickening agent for shearing.
The third aspect of the invention provides the application of the topramezone-containing suspending agent in the prevention and treatment of grassy weeds and broadleaf weeds in sorghum fields.
Compared with the prior art, the invention has at least the following beneficial effects:
(1) The topramezone-containing suspending agent has excellent cold and heat storage property;
(2) The active ingredient of the topramezone-containing suspending agent has long effective time.
Detailed Description
In order to facilitate understanding of the technical aspects and technical effects of the present invention, the present invention will be described in detail with reference to the following specific embodiments. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, definitions, will control.
The invention provides a topramezone-containing suspending agent, which comprises the following components in percentage by mass: 20-40wt% of topramezone raw material, 3-5wt% of dispersing agent, 2-3wt% of wetting agent, 0.05-0.2wt% of defoaming agent, 0.08-1.2wt% of inorganic salt, 0.9-1.3wt% of thickening agent, 0-0.5wt% of other auxiliary materials and the balance of water.
In the invention, the interaction of all components in the suspending agent, especially the interaction among the components according to the mass content can better increase the stability of the suspending agent containing topramezone, especially the interaction of the dispersing agent and the inorganic salt in the components can further increase the stability of the suspending agent containing topramezone.
In order to further increase the overall effect of the topramezone-containing suspension in the present invention, in a preferred embodiment, the suspension comprises, in mass percent: 30wt% of topramezone raw material, 4wt% of dispersing agent, 2.5wt% of wetting agent, 0.1wt% of defoaming agent, 1wt% of inorganic salt, 1.12wt% of thickening agent, 0.2wt% of other auxiliary materials and the balance of water.
In one embodiment, the dispersant is selected from one or more of sodium lignosulfonate, an ethylene oxide-propylene oxide block copolymer, a carboxylate polymer, sodium methylene dinaphthyl sulfonate, morwet D-425 and terspin-2500, preferably Morwet D-425.
In one embodiment, the wetting agent is selected from fatty alcohol-polyoxyethylene ethers.
In a preferred embodiment, the fatty alcohol-polyoxyethylene ether is selected from the group consisting of C10-C20 alcohol-polyoxyethylene ethers, preferably from the group consisting of C10-C15 alcohol-polyoxyethylene ethers, more preferably from the group consisting of C13 alcohol-polyoxyethylene ethers.
C13 alcohol-polyoxyethylene in the present inventionThe ethers are commercially available under the trade nameTO 8 (Basoff).
In the invention, the fatty alcohol-polyoxyethylene ether belongs to a nonionic surfactant, can provide steric hindrance, and can better interact with the dispersing agent to absorb and wrap the original drug particles.
The suspension containing topramezone is often required to be stirred in the preparation process, and high foamability is a common problem in the stirring process, and the problem can cause that the suspension containing topramezone can not reach the pesticide dilution degree in the use process, so that the pesticide effect is reduced, and therefore, the defoamer is added into the suspension containing topramezone; the silicone-based antifoaming agent itself has excellent stability and strong antifoaming force, and in a preferred embodiment, the antifoaming agent is a silicone-based antifoaming agent, wherein the specific kind of silicone antifoaming agent is not particularly limited, for example, SAG1522, SAG1572, BS-163, preferably SAG1522.
In one embodiment, the inorganic salt is selected from at least one of sodium chloride, potassium pyrophosphate, sodium pyrophosphate, and potassium citrate, preferably sodium chloride.
The active ingredient of the topramezone has strong hydrophilicity, has larger solubility in water and exponentially increases with the increase of pH, and the topramezone is prepared into an SC dosage form in the prior art, on one hand, because the active ingredient has strong hydrophilicity, the dispersing agent is easy to desorb from the surface of the active ingredient, thereby losing the function; on the other hand, the solubility of the active ingredient in water is large, the problem of particle growth or effective ingredient crystallization can occur in the long-term storage process, and the amicarbazone-containing suspending agent has excellent stability in the long-term storage process, and the inventor of the application speculates that: on the one hand, the sodium salt dispersant (Morwet D-425) of naphthalene sulfonate formaldehyde condensate with high lipophilicity and corresponding structure used in the invention is helpful for anchoring and desorption of surface activity on the effective cost surface; on the other hand, after inorganic salt, especially sodium chloride, is added into the system, the electrostatic repulsive force between the dispersing agent and the topramezone can be shielded, so that the adsorption of dispersing agent molecules on the particle surface is increased.
In the present invention, the addition of a thickener, which in a preferred embodiment is selected from at least one of magnesium aluminum silicate, white carbon black, magnesium aluminum silicate, sodium alginate, xanthan gum and polyvinyl alcohol, is capable of adjusting the rheology and flowability of the topramezone-containing suspension.
In a more preferred embodiment, the thickener is a combination of magnesium aluminum silicate and xanthan gum, preferably the mass ratio of magnesium aluminum silicate to xanthan gum is 1: (0.1-0.15), more preferably 1:0.12.
The magnesium aluminum silicate and the xanthan gum can be obtained through the market, preferably the magnesium aluminum silicate is purchased from Hui-metal mineral new materials built in Suzhou, the brand is SF-04, and preferably the xanthan gum is purchased from Zhongxuan Biochemical Co.
In the invention, the aluminum magnesium silicate has poor capability of improving the viscosity of the topramezone-containing suspending agent when being used alone, and the single thickener has poor capability of improving the viscosity of the preparation.
In the present invention, other auxiliary materials which may be needed may be added to the suspending agent according to need, and in one embodiment, the other auxiliary materials include a preservative, the specific type of the preservative is not particularly limited, preferably, the preservative is a BIT preservative, and further preferably, the brand of the BIT preservative is G20S.
In a preferred embodiment, the preservative is present in the topramezone-containing suspension in an amount of 0.05 to 0.15wt%, preferably 0.1wt%.
In a preferred embodiment, the further auxiliary material comprises an antifreeze agent.
In a more preferred embodiment, the antifreeze is an ionic liquid, preferably the ionic liquid is an imidazolium-based ionic liquid, preferably 1-butyl-3-methylimidazole iodide, 1-butyl-3-methylimidazole chloride, and more preferably 1-butyl-3-methylimidazole iodide.
In a preferred embodiment, the antifreeze is present in the topramezone-containing suspension in an amount of 0.05 to 0.15% by weight, preferably 0.1% by weight.
At present, the antifreezing agent used in the prior art is an alcohol antifreezing agent, such as ethylene glycol, but volatilization and degradation of alcohol substances are limited, and meanwhile, the alcohol substances can accumulate in seeds and young plants and can generate phytotoxicity for inhibiting plants from carrying out aerobic respiration, damaging plant nutrition synthesis and the like. The inventor of the application found that the use of the ionic liquid as the antifreeze in the present invention can not only increase the low-temperature storage property of the topramezone-containing suspension agent, but also increase the efficacy of topramezone in the topramezone-containing suspension agent, and the inventor of the present application speculates that the ionic liquid is probably because the ionic liquid is a metal salt with an extremely low freezing point, and the ionic liquid itself can provide free moving anions and cations, but the system of the ionic liquid in the present invention has a certain solubilization effect on topramezone, which can reduce the effective time of the topramezone-containing suspension agent, and the applicant of the present application unexpectedly found that the addition of a certain amount of inorganic salt can reduce the solubility of the effective ingredient in water, and improve the defects brought by the ionic liquid.
The second aspect of the invention provides a preparation method of the topramezone-containing suspending agent, which comprises the following steps: the dispersion material containing topramezone raw material, dispersing agent, wetting agent, defoaming agent, inorganic salt, other auxiliary materials and water is subjected to at least one-time grinding, and then added with thickening agent for shearing.
In the invention, the method for obtaining the dispersion material containing the topramezone raw material, the dispersing agent, the wetting agent, the defoaming agent, the inorganic salt, other auxiliary materials and the water is not particularly limited, for example, the topramezone raw material, the wetting agent, the dispersing agent, the defoaming agent, the inorganic salt, the other auxiliary materials and the water are subjected to homogenizing shearing for 20-50min at 1800-2500 rpm.
In the present invention, the conditions for shearing by adding the thickener are not particularly limited, and it is preferably obtained by shearing at 1800 to 2500rpm for 20 to 50 minutes.
In a preferred embodiment, the dispersion containing topramezone raw material, a dispersing agent, a defoaming agent, inorganic salts, other auxiliary materials and water is firstly ground once to a particle size of 270-400 meshes to obtain a first grinding material, then half of the mass of the first grinding material is ground twice to a particle size of 650-800 meshes to obtain a second grinding material, and the first grinding material and the second grinding material are mixed to obtain the grinding material.
In the experimental process, the inventor of the application finds that when the dispersion material is directly ground to the particle size of 650-800 meshes, the thermal storage phenomenon of the topramezone-containing suspending agent is poor, probably because the thermal motion polyaddition of the raw material with smaller particle size is carried out when the temperature is higher, the surface of the raw material particles cannot be covered by the wetting dispersing agent with unchanged total content, so that the raw material is easier to separate out, the thermal storage phenomenon of the topramezone-containing suspending agent can be better increased by adopting the twice grinding method of the inventor, the effective time of the pesticide is prolonged, and the raw material with different particle sizes can form a card-type combined network structure with the aluminum magnesium silicate in an aqueous medium more tightly in a system, and meanwhile, the aluminum magnesium silicate can carry out better coating on the raw material with different particle sizes, so that the pesticide effect slowly diffuses out, and the effective time of the pesticide is prolonged.
The third aspect of the invention provides the application of the topramezone-containing suspending agent in the prevention and treatment of grassy weeds and broadleaf weeds in sorghum fields.
In a preferred embodiment, the application is used in the 3-5 leaf stage of sorghum.
The invention is specifically described by the following examples, in which magnesium aluminum silicate is purchased from Jian Hui-input mineral New Material, brand SF-04, of Suzhou country; xanthan gum was purchased from Zhongxuan Biochemical Co., ltd.
Example 1
According to mass percentage, the topramezone raw material is taken to be 30 weight percent, the Morwet D-425 dispersant is taken to be 4 weight percent, and the C13 alcohol polyoxyethylene ether (with the trade mark is takenTO 8 (Pasteff)) 2.5wt%, SAG1522 defoamer 0.1wt%, sodium chloride 1wt%, magnesium aluminum silicate 1wt%, xanthan gum 0.12wt%, BIT prevention0.1wt% of a corrosion inhibitor, 0.1wt% of iodized 1-butyl-3-methylimidazole and the balance of water for standby;
the topramezone technical, morwet D-425 dispersant and C13 alcohol polyoxyethylene ether (brand number)TO 8 (Basoff)), SAG1522 defoamer, sodium chloride, BIT preservative, 1-butyl-3-methylimidazole iodide and water were homogenized and sheared at 2000rpm for 30min TO obtain a dispersion;
grinding the dispersion liquid to 325 meshes to obtain a first grinding material, taking half of the mass of the first grinding material to carry out secondary grinding to 800 meshes to obtain a second grinding material, and mixing the first grinding material and the second grinding material to obtain a grinding material;
adding magnesium aluminum silicate and xanthan gum into the grinding material, and carrying out homogenizing shearing for 30min at 2000rpm to obtain the suspension containing 30% topramezone.
Example 2
According to mass percentage, the topramezone raw material is taken to be 30 weight percent, the Morwet D-425 dispersing agent is taken to be 4.5 weight percent, and the C13 alcohol polyoxyethylene ether (with the brand number isTO 8 (Pasteff)) 3wt%, SAG1522 defoamer 0.1wt%, sodium chloride 1.2wt%, magnesium aluminum silicate 1wt%, xanthan gum 0.12wt%, BIT preservative 0.1wt%, iodinated 1-butyl-3-methylimidazole 0.1wt% and the balance water for standby;
the topramezone technical, morwet D-425 dispersant and C13 alcohol polyoxyethylene ether (brand number)TO 8 (Basoff)), SAG1522 defoamer, sodium chloride, BIT preservative, 1-butyl-3-methylimidazole iodide and water were homogeneously sheared at 2500rpm for 20 min.
Grinding the dispersion liquid to 325 meshes to obtain a first grinding material, taking half of the mass of the first grinding material to carry out secondary grinding to 800 meshes to obtain a second grinding material, and mixing the first grinding material and the second grinding material to obtain a grinding material;
adding magnesium aluminum silicate and xanthan gum into the grinding material, and carrying out homogenizing shearing for 20min at 2500rpm to obtain the suspension containing 30% topramezone.
Example 3
According to mass percentage, the topramezone raw material is taken to be 30 weight percent, the Morwet D-425 dispersant is taken to be 4 weight percent, and the C13 alcohol polyoxyethylene ether (with the trade mark is takenTO 8 (Pasteff)) 2wt%, SAG1522 defoamer 0.08wt%, sodium chloride 1wt%, magnesium aluminum silicate 1wt%, xanthan gum 0.12wt%, BIT preservative 0.1wt%, iodinated 1-butyl-3-methylimidazole 0.1wt% and the balance water for standby;
the topramezone technical, morwet D-425 dispersant and C13 alcohol polyoxyethylene ether (brand number)TO 8 (Basoff)), SAG1522 defoamer, sodium chloride, BIT preservative, 1-butyl-3-methylimidazole iodide and water were homogeneously sheared at 1800rpm for 50min TO obtain a dispersion;
grinding the dispersion liquid to 325 meshes to obtain a first grinding material, taking half of the mass of the first grinding material to carry out secondary grinding to 800 meshes to obtain a second grinding material, and mixing the first grinding material and the second grinding material to obtain a grinding material;
adding magnesium aluminum silicate and xanthan gum into the grinding material, and carrying out homogenizing shearing for 50min at 1800rpm to obtain the suspension containing 30% topramezone.
Example 4
According to mass percentage, the topramezone raw material is taken to be 30 weight percent, the Morwet D-425 dispersant is taken to be 4 weight percent, and the C13 alcohol polyoxyethylene ether (with the trade mark is takenTO 8 (Basoff)) 2.5wt%, SAG1522 defoamer 0.1wt%, sodium chloride 1wt%, magnesium aluminum silicate 1wt%, xanthan gum 0.12wt%, BIT preservative 0.1wt% and the balance water for standby;
the topramezone technical, morwet D-425 dispersant and C13 alcohol polyoxyethylene ether are treatedNumber of marks isTO 8 (Basoff)), SAG1522 defoamer, sodium chloride, BIT preservative and water were homogeneously sheared at 2000rpm for 30min TO obtain a dispersion;
grinding the dispersion liquid to 325 meshes to obtain a first grinding material, taking half of the mass of the first grinding material to carry out secondary grinding to 800 meshes to obtain a second grinding material, and mixing the first grinding material and the second grinding material to obtain a grinding material;
adding magnesium aluminum silicate and xanthan gum into the grinding material, and carrying out homogenizing shearing for 30min at 2000rpm to obtain the suspension containing 30% topramezone.
Example 5
According to mass percentage, the topramezone raw material is taken to be 30 weight percent, the Morwet D-425 dispersant is taken to be 4 weight percent, and the C13 alcohol polyoxyethylene ether (with the trade mark is takenTO 8 (Pasteff)) 2.5wt%, SAG1522 defoamer 0.1wt%, sodium chloride 1wt%, magnesium aluminum silicate 1wt%, xanthan gum 0.12wt%, BIT preservative 0.1wt%, iodinated 1-butyl-3-methylimidazole 0.1wt% and the balance water for standby;
the topramezone technical, morwet D-425 dispersant and C13 alcohol polyoxyethylene ether (brand number)TO 8 (Basoff)), SAG1522 defoamer, sodium chloride, BIT preservative, 1-butyl-3-methylimidazole iodide and water were homogenized and sheared at 2000rpm for 30min TO obtain a dispersion;
grinding the dispersion liquid to a particle size of 325 meshes to obtain a first grinding material, and secondarily grinding the first grinding material to a particle size of 800 meshes to obtain a second grinding material;
and adding magnesium aluminum silicate and xanthan gum into the second grinding material, and carrying out homogenizing shearing for 30min at 2000rpm to obtain the suspension containing 30% topramezone.
Comparative example 1
According to the mass percentage, the topramezone raw material is taken to be 30 weight percent and the Morwet D-425 is taken4wt% of powder and C13 alcohol polyoxyethylene ether (brand number is)TO 8 (Basoff)) 2.5wt%, SAG1522 defoamer 0.1wt%, magnesium aluminum silicate 1wt%, xanthan gum 0.12wt%, BIT preservative 0.1wt% and the balance water for standby;
the topramezone technical, morwet D-425 dispersant and C13 alcohol polyoxyethylene ether (brand number)TO 8 (Basoff)), SAG1522 defoamer, BIT preservative and water were homogeneously sheared at 2000rpm for 30min TO obtain a dispersion;
grinding the dispersion liquid to 325 meshes to obtain a first grinding material, taking half of the mass of the first grinding material to carry out secondary grinding to 800 meshes to obtain a second grinding material, and mixing the first grinding material and the second grinding material to obtain a grinding material;
adding magnesium aluminum silicate and xanthan gum into the grinding material, and carrying out homogenizing shearing for 30min at 2000rpm to obtain the suspension containing 30% topramezone.
Evaluation of Performance
1. The field efficacy test was performed in the suspension containing 30% topramezone in examples 1-3, 5, and the control agent: a commercially available 38% atrazine suspension.
1. Test basic information
1.1, test basis: the test complies with the pesticide registration test quality management Specification, NY/T1464.61-2016 pesticide field efficacy test criterion part 61: herbicide placement sorghum field weeds and HLJZB/BH012-2018 "standard operating procedure for herbicide control of sorghum weeds".
2. Environmental and facility cultivation conditions
2.1, position of test site: the Harbin citizen is in the agricultural science test park of Heilongjiang province.
2.2, test target conditions: annual grass weeds are mainly barnyard grass (Echinochloarus-galli), annual broadleaf weeds are mainly chenopodium quinoa (Chenopodium album), polygonum benthamianum (Polygonum benthamianum), abutilon theshrasti (Abutilon thesiti), solanum nigrum (Solamum nigrum), etc.
2.3, test crop, variety and growth conditions: sorghum is planted in the variety of Longzai No. 25 and is sown in the period of 5 months and 21 days, and the sowing amount is 9kg/hm 3 Sorghum grows normally when the pesticide is applied.
2.4, test soil type: the test soil is black soil, has medium texture, 3.62 percent of organic matter and 6.79 of pH value. The corn of the previous crop is turned over in autumn, the fertilizer is applied in autumn, ridges are formed in autumn, and the ridge distance is 65cm. The balloon was re-spun for 5 months and 16 days.
2.5, water and fertilizer management in test lands: and (5) performing normal field water and fertilizer management.
2.6, meteorological data: the medicine is applied on 19 days of 6 months, the medicine application day is cloudy, and the average daily wind speed is 2.3m/s. The average daily air temperature is 18.7 ℃, the highest air temperature is 21.6 ℃, the lowest air temperature is 14.2 ℃, and the average relative humidity is 60 percent. The average temperature is 19.3 ℃ 10 days before the application, the highest temperature is 28.3 ℃, the lowest temperature is 10.9 ℃, the temperature is reduced for 3 days, and the accumulated rainfall is 20.6mm. The average temperature is 19.4 ℃ after the application of the medicine, the highest temperature is 27.7 ℃, the lowest temperature is 14.7 ℃, the temperature is reduced in 7 days, and the accumulated rainfall is 61.6mm.
3. Test design and arrangement
3.1, the dosage and the number of the medicament are shown in Table 1
TABLE 1
3.2 cell arrangement
3.2.1 cell arrangement is as follows:
3.2.2, cell area and repetition: cell nep 20m 2 The method comprises the steps of carrying out a first treatment on the surface of the Number of repetitions: 4 times.
3.3 methods of administering the drugs
3.3.1, use period and method: spraying stems and leaves after sorghum seedlings are grown.
3.3.2, applicator device: the application adopts a special knapsack compression sprayer for the district, 2m of spraying width, 4 flat fan-shaped nozzles and working pressure of 4kg/cm 2 。
3.3.3, time and frequency of application: the application time is 6 months and 19 days, and the period of 3-5 leaves of the sorghum is used for application. Barnyard grass in 2-4 leaf stage, i.e. broadleaf weed quinoa, polygonum benthamianum in 2-4cm, piemarker and black nightshade in 2-3 leaf in 2-3cm. Spraying the medicine once in the whole growth period.
3.3.4, usage capacity: the spray rate was 450 liters/hectare.
3.4 investigation method, time and times
3.4.1, investigation time and times: the first time, investigating the weed base number before application; secondly, investigating the weed plant number prevention effect 15 days after the application; and thirdly, investigating the weed plant number control effect and fresh weight control effect 30 days after the application.
3.4.2, investigation method: according to criterion section 61, 4 points per cell are investigated, 0.25m per point 2 . The plant number or fresh weight control effect of each weed is calculated respectively, and after 1 week of application, annual gramineous weeds and broadleaf weeds in each dose treatment area of the 30% topramezone suspension are removed, and broadleaf weed leaves such as chenopodium quinoa, polygonum bennett, abutilon and black nightshade begin to dry. After 2 weeks of application, the polygonum benthamianum, abutilon and black nightshade are basically dead, some grass and quinoa remain in each treatment area, the growth is inhibited, and the residual weeds gradually decrease with increasing dosage. Later observation shows that barnyard grass and quinoa remaining in each treatment area can resume normal growth.
3.4.3, a drug effect calculation method: according to the rule 61, the control effect (%) = (CK-PT)/CK 100 in the formula (1) in the standard number NY/T1464.61-2016 is cited, wherein PT is the number of residual grasses (or fresh weight) in the treated area, and CK is the number of live grasses (or fresh weight) in the blank area.
3.5 direct impact on crop
3.5.1, investigation time and times
The first time is 1-2 weeks after treatment. The second time is 3-4 weeks after treatment, the third time is when the sorghum withdraws the ears, and the fourth time is the pre-harvest yield measurement.
3.5.2, investigation method: after administration, the response of sorghum to the agent was recorded by observation. If the phytotoxicity occurs, recording the occurrence degree, occurrence time and recovery time of the phytotoxicity, and observing 3 and 10 days after the application, wherein the sorghum heart leaves of each treatment area of the 30% topramezone suspending agent have slight fading. 2 weeks after application, the sorghum leaves in the 3 dose treatment areas were normally colored, except that the sorghum growth in the 54 g/hectare treatment area was slightly inhibited and the lower leaves were still white, and the fresh leaves in each treatment were normal. As a result of the measurement, the yield of each treatment area is obviously increased compared with that of a blank control.
3.6, yield and quality
3.7 influence on other organisms
No effect on other organisms was found.
4. Test results and analysis
Table 2 shows the herbicidal effect (number of strains) of the suspension containing 30% topramezone of examples 1 to 3 against Gao Liangtian annual weeds, 15 days after the application.
TABLE 2
Table 3 shows the herbicidal effect (number of strains) of 30% topramezone suspension in examples 1 to 3 against Gao Liangtian annual weeds for 30 days after the application.
TABLE 3 Table 3
Table 4 shows the herbicidal effect (fresh weight%) of 30% topramezone suspension in examples 1 to 3 against Gao Liangtian annual weeds 30 days after the application.
TABLE 4 Table 4
5. Conclusion(s)
30 days after application, the effective components of the suspension agent of the topramezone of 30% in examples 1-3 and 5 are respectively 87.9%, 91.9%, 94.3%, 84.2% and the fresh weight prevention effects of the suspension agent of the topramezone of 22.5, 27, 31.5 and 54 g/hectare treatment on annual grass weeds are respectively 89.6%, 93.4%, 96.4% and 85.5%, the total plant number prevention effects on annual broadleaf weeds are respectively 92.1%, 95.8%, 98.6% and 87.9%, and the total fresh weight prevention effects are respectively 94.9%, 97.6%, 99.4% and 91.3%. The total plant number prevention effect on annual weeds is 90.8%, 94.7%, 97.3% and 86.8%, and the total fresh weight prevention effect is 93.3%, 96.4%, 98.5% and 89.6%.
By combining the test results, the herbicide 30% suspension containing topramezone provided in the example is used for spraying treatment of post-seedling stems and leaves of sorghum fields, the proper application period is 3-5 leaf period of sorghum, 2-4 leaf period of annual gramineous weeds and annual broadleaf weed plant height below 5cm. Has good control effect on annual broadleaf weeds such as sorghum field Polygonum benthamianum, water acanthopanax, crowndaisy chrysanthemum and the like, and has good control effect on barnyard grass and quinoa.
Safety: under the climate condition of the present year (2020), the sorghum leaves have the phenomenon of fading green and yellowing white after the recommended dosage is applied, and can be recovered in the later period, and the yield is not affected by the newborns She Zhengchang. The weeding yield-increasing effect is remarkable, and no influence on other plant diseases and insect pests, natural enemies and other non-target organisms is found.
2. Persistent foamability was measured according to GB/T28137-2011.
3. Pourability was carried out according to HG/T2467.5-2003 "pourability test".
4. Wet screening experiments: according to GB/T16150-1995.
5. Thermal storage stability: about 20g of the suspension sample was sucked up by a syringe, poured into a clean ampoule, sealed at high temperature, placed in a constant temperature (54.+ -. 2 ℃) incubator, stored for 14 days under heat, and then taken out, and the suspensions were detected separately.
6. Cold storage stability: 80mL of the suspending agent is placed in a 100mL beaker, the suspending agent is kept for 1h in a refrigerator (-5+/-2 ℃), stirring is carried out every 15 minutes for 15s, the appearance change is observed, the beaker is put back into the refrigerator, the suspending agent is placed for 7 days at (-5+/-2 ℃), the suspending agent is taken out after 7 days, and the suspending agent is placed to room temperature to test the suspending rate of the suspending agent respectively.
The persistent foamability, pourability, suspension rate, wet sieve test, suspension rate after heat storage and suspension rate after cold storage are shown in table 8.
TABLE 8
The examples show that the suspension containing topramezone has the advantages of excellent stability and long effective time of the effective components.

Claims (10)

1. A topramezone-containing suspending agent, which is characterized by comprising the following components in percentage by mass: 20-40wt% of topramezone raw material, 3-5wt% of dispersing agent, 2-3wt% of wetting agent, 0.05-0.2wt% of defoaming agent, 0.08-1.2wt% of inorganic salt, 0.9-1.3wt% of thickening agent, 0-0.5wt% of other auxiliary materials and the balance of water.
2. The suspension of claim 1, wherein the dispersant is selected from one or more of sodium lignin sulfonate, ethylene oxide-propylene oxide block copolymers, carboxylate high molecular polymers, sodium methylene bis naphthalene sulfonate, morwet D-425, and terspin-2500.
3. A suspension according to claim 1 or 2, wherein the wetting agent is selected from fatty alcohol polyoxyethylene ethers.
4. A suspension according to claim 3, wherein the fatty alcohol-polyoxyethylene ether is selected from C10-C20 alcohol-polyoxyethylene ethers.
5. The suspension according to claim 1 or 2, wherein the inorganic salt is selected from at least one of sodium chloride, potassium pyrophosphate, sodium pyrophosphate and potassium citrate.
6. The suspension according to claim 1 or 2, wherein the thickener is selected from at least one of magnesium aluminum silicate, white carbon black, magnesium aluminum silicate, sodium alginate, xanthan gum and polyvinyl alcohol.
7. A suspension according to claim 1 or 2, wherein the further adjuvant comprises a preservative.
8. A method for preparing the topramezone-containing suspension as claimed in any one of claims 1 to 7, comprising the steps of: the dispersion material containing topramezone raw material, dispersing agent, wetting agent, defoaming agent, inorganic salt, other auxiliary materials and water is subjected to at least one-time grinding, and then added with thickening agent for shearing.
9. Use of a topramezone-containing suspension as defined in any one of claims 1 to 7 for controlling grassy weeds and broadleaf weeds in sorghum fields.
10. The use according to claim 9, wherein the use is in the 3-5 leaf stage of sorghum.
CN202311462804.9A 2023-11-06 2023-11-06 Suspension containing topramezone and preparation method and application thereof Pending CN117413827A (en)

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