CN117398439A - Traditional Chinese medicine composition for treating constipation - Google Patents
Traditional Chinese medicine composition for treating constipation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and/or treating constipation, which is prepared from the following raw materials in parts by weight: 5 to 25 parts of cistanche, 1 to 10 parts of cinnamon, 5 to 25 parts of mulberry, 1 to 10 parts of rhizoma polygonati, 5 to 25 parts of astragalus, 1 to 10 parts of cimicifuga foetida, 1 to 10 parts of fructus aurantii immaturus, 1 to 10 parts of snakegourd fruit, 5 to 25 parts of angelica, 5 to 25 parts of peach kernel and 1 to 10 parts of jujube. Experiments prove that the composition has definite curative effect on constipation after spine fracture, can obviously improve clinical symptoms and negative emotion of patients in traditional Chinese medicine, promotes defecation, is safe and effective, and has clinical popularization and application values.
Description
Technical Field
The invention particularly relates to a traditional Chinese medicine composition for treating constipation.
Background
Constipation is the reduction of the number of times of defecation, and simultaneously, the difficulty of defecation and the dry and hard stool. Normal people defecate 1-2 times a day or 1-2 times a day, constipation patients defecate less than 3 times a week, and the defecation is laborious, and the stool is hard and the amount is small. Abdominal distension and constipation are one of the main complications of early spinal fracture, and patients suffer from great pain and severe pain. Western medicine considers that spinal cord concussion is caused after spinal fracture, incomplete visceral paralysis is generated, and constipation is mainly caused by intestinal anesthesia. The traditional Chinese medicine considers that the bones and tendons are broken, the veins are damaged, blood overflows outside the intestines, blood stasis accumulates in the abdomen, and constipation is caused by blood stasis, qi stagnation, qi dysfunction and gastrointestinal conduction dysfunction.
At present, the traditional Chinese medicine compound for treating constipation caused by spine fracture is more. Huang Haiyan A Chinese medicinal preparation for treating early abdominal distension and constipation of spine fracture, especially constipation caused by spine fracture, has a certain curative effect, but has rapid action, and can be used for treating the early abdominal distension and constipation of spine fracture, and 2 doses are not effective, so that the Chinese medicinal preparation with good curative effect and high safety is necessary to be developed.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for preventing and/or treating constipation, which is prepared from the following raw materials in parts by weight:
5 to 25 parts of cistanche, 1 to 10 parts of cinnamon, 5 to 25 parts of mulberry, 1 to 10 parts of rhizoma polygonati, 5 to 25 parts of astragalus, 1 to 10 parts of cimicifuga foetida, 1 to 10 parts of fructus aurantii immaturus, 1 to 10 parts of snakegourd fruit, 5 to 25 parts of angelica, 5 to 25 parts of peach kernel and 1 to 10 parts of jujube.
Further, the material is prepared from the following raw materials in parts by weight:
7-13 parts of cistanche, 2-8 parts of cinnamon, 7-13 parts of mulberry, 2-8 parts of rhizoma polygonati, 7-13 parts of astragalus, 2-8 parts of cimicifuga foetida, 2-8 parts of fructus aurantii immaturus, 2-8 parts of snakegourd fruit, 7-13 parts of angelica sinensis, 7-13 parts of peach kernel and 2-8 parts of jujube.
Further, the material is prepared from the following raw materials in parts by weight:
10 parts of cistanche, 5 parts of cinnamon, 10 parts of mulberry, 5 parts of rhizoma polygonati, 10 parts of astragalus, 5 parts of cimicifuga foetida, 5 parts of fructus aurantii immaturus, 5 parts of snakegourd fruit, 10 parts of angelica sinensis, 10 parts of peach kernel and 5 parts of jujube.
Further, the preparation is prepared by taking medicinal powder of the raw material medicine or water or organic solvent extract of the raw material medicine as an active ingredient and adding pharmaceutically acceptable auxiliary materials.
Still further, the formulation is an oral formulation.
Further, the oral preparation is a solution, a paste, a pill tablet or a granule.
The invention also provides a preparation method of the traditional Chinese medicine composition, which is characterized in that: it comprises the following steps:
(1) Weighing the raw materials according to the proportion;
(2) Grinding the raw materials into powder, or extracting with water or organic solvent, and adding adjuvants or auxiliary components commonly used in medicine.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines for preventing and/or treating constipation.
Further, the medicine is a medicine for treating constipation after fracture, preferably a medicine for treating constipation, abdominal distension and weakness of defecation caused by qi deficiency and stasis after fracture.
Further, the medicine has the effects of strengthening yang, removing qi, removing blood stasis and relaxing the bowels.
The invention finally provides application of the traditional Chinese medicine composition and polyethylene glycol 4000 powder in preparing a medicine for treating constipation, wherein the mass ratio of the traditional Chinese medicine composition to the polyethylene glycol 4000 powder is 49-113, preferably 85:20.
further, the medicine is a medicine for treating constipation after fracture.
In the composition, cistanche salsa and astragalus root are taken as monarch drugs, and the effects of warming yang and qi, tonifying qi and moistening intestines are taken as the base of the composition; cinnamon is used for inducing fire to return to the original state, and rhizoma polygonati is used as a ministerial drug for tonifying qi; semen Persicae, radix Angelicae sinensis, fructus Mori, cimicifugae rhizoma, fructus Aurantii Immaturus, and fructus Trichosanthis for warming yang, invigorating spleen, tonifying kidney, and moistening intestine, and for warming yang, relieving constipation, and promoting circulation; cimicifugae rhizoma, rhizoma cimicifugae, fructus Jujubae, and fructus Jujubae are used together to treat excessive diarrhea. The whole formula has the effects of strengthening yang, resolving qi, removing blood stasis and relaxing the bowels. Experiments prove that the composition has definite curative effect on treating the constipation caused by the spine fracture, can obviously improve the clinical symptoms and negative emotion of the traditional Chinese medicine of a patient, promotes defecation, is safe and effective, and has clinical popularization and application values.
It should be apparent that, in light of the foregoing, various modifications, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
The above-described aspects of the present invention will be described in further detail below with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above subject matter of the present invention is limited to the following examples only. All techniques implemented based on the above description of the invention are within the scope of the invention.
Detailed Description
The raw materials and equipment used in the specific embodiment of the invention are all known products and are obtained by purchasing commercial products, wherein the modern Chinese medicinal preparation prepared from the Chinese medicinal composition is prepared by a mature preparation process and by referring to the conventional method in the prior art.
EXAMPLE 1 preparation of the medicament of the invention
The formula comprises the following components: cistanche 10g, cinnamon 5g, mulberry 10g, rhizoma polygonati 5g, astragalus 10g, cimicifuga rhizome 5g, fructus aurantii 5g, immature bitter orange 5g, snakegourd fruit 5g, angelica 10g, peach kernel 10g and jujube 5g
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 10 times of water, decocting for 2 times each for 1.5 hours, filtering, combining the filtrates, concentrating the filtrate under reduced pressure to obtain thick paste, and adding common auxiliary materials on medicines to prepare a daily dose granule.
EXAMPLE 2 preparation of the medicament of the invention
The formula comprises the following components: 7g of cistanche, 2g of cinnamon, 7g of mulberry, 2g of rhizoma polygonati, 7g of astragalus, 2g of cimicifuga foetida, 2g of fructus aurantii immaturus, 2g of fructus trichosanthis, 7g of angelica sinensis, 7g of peach kernel and 2g of jujube
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 10 times of water, decocting for 2 times each for 1.5 hours, filtering, combining the filtrates, concentrating the filtrate under reduced pressure to obtain thick paste, adding common auxiliary materials on medicines, and preparing into tablets with daily dosage.
EXAMPLE 3 preparation of the medicament of the invention
The formula comprises the following components: 13g of cistanche, 8g of cinnamon, 13g of mulberry, 8g of rhizoma polygonati, 13g of astragalus, 8g of cimicifuga foetida, 8g of fructus aurantii immaturus, 8g of fructus trichosanthis, 7g of angelica sinensis, 13g of peach kernel and 8g of jujube.
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 8 times of water, decocting for 2 times, each time for 1.5 hours, filtering, and combining the filtrates to obtain a daily dose of liquid medicine.
The advantageous effects of the present invention are described below by way of test examples.
Test example 1 clinical study of the Constipation treatment with the Chinese medicinal composition of the present invention
1. Clinical data
120 constipation patients after the vertebral fracture collected and treated by the traditional Chinese medicine hospitals in 5 months 2022 to 7 months 2023 are selected as study objects, the study objects are divided into 60 observation groups and 60 control groups by adopting a random number method, the control group is treated by conventional western medicines, the observation groups are treated by qi-dissolving, stasis-removing and claustrophobia-removing methods on the basis of the conventional western medicines, the two groups of curative effects are compared, the influence on constipation symptoms, emotional states and recurrence rate of the patients is analyzed, and the incidence rate of adverse reactions is recorded.
2. Diagnostic criteria
2.1 Western diagnostic criteria:
reference to functional constipation roman iii diagnostic criteria: the following 2 or more symptoms must be included. A. At least 25% of the bowel movements are laborious; B. at least 25% of the bowel movement is lumpy or hard; C. at least 25% of the bowel movements have a feeling of inconvenience; D. at least 25% of the bowel movements are anorectal obstructive; E. at least 25% of the bowel movements require manual assistance; F. defecation was performed less than 3 times per week.
2.2 diagnostic criteria for chinese medicine:
referring to the clinical research guidelines of new Chinese medicine issued by China: A. difficult defecation, a plurality of days, dry or sticky stool; B. cold face and body, fullness in chest and hypochondrium; C. lassitude, debilitation, spontaneous perspiration, less qi, no speaking, pale complexion, shortness of breath, palpitation; D. purple and dark tongue with white and greasy coating; E. the urine is cooled; F. the pulse is slippery, wiry and thin.
3. The treatment method comprises the following steps:
control group: polyethylene glycol 4000 powder, 10g once, twice a day. (national medicine standard H20080092 Ma Ying Long pharmaceutical Co., ltd.)
Observation group: the formulation (granule prepared in example 1) for removing qi and blood stasis and dredging claustrade was used on the basis of the administration of the control group, once a day, three times a day.
Treatment course: both groups of patients were continuously treated for 1 week as a treatment course, and the treatment was 2 treatment courses, and the statistics was effective.
4. Observation index
1) Constipation patient clinical scoring system (Cleveland Constipation Score)
The system comprises 8 aspects (the integral is divided into 0-4 according to the degree from light to heavy) of defecation frequency, defecation laborious degree, defecation degree, abdominal pain degree, defecation time each time, type of help needed during defecation, unsuccessful times every 24 hours and constipation course. The lowest score is 0 and the highest score is 30, and the higher the score, the more serious the disease.
2) Stool character integral evaluation
The stool characteristic score adopts a Bristol stool characteristic typing method, wherein the type 1 is a separated hard lump (1 minute), the type 2 is a lump (2 minute), the type 3 is a split sausage (3 minute), the type 4 is a soft sausage (4 minute), the type 5 is a soft lump (5 minute), the type 6 is pasty stool (6 minute), and the type 7 is watery stool (7 minute). Higher scores indicate lighter conditions.
3) Integral evaluation of Chinese medicine symptoms of constipation patient
The Chinese medicine symptoms of each group of constipation patients are scored before and after treatment, and the scores are compared before and after treatment. The score was recorded as 2 points and 0 points, respectively, according to the presence or absence of the score. Higher scores indicate a heavier deficiency syndrome, and vice versa. The specific integral evaluation is shown in table 1.
Integral of symptoms in TCM
4. Standard of efficacy
Reference is made to the Congress anorectal surgery group Congress of China medical society and clinical efficacy evaluation criteria in 2005:
1) Clinical recovery: the symptoms disappeared and the stool was normal, with the integral zero.
2) The effect is shown: the constipation symptom is obviously improved, and the integral is reduced by more than or equal to 2/3 compared with the integral before treatment.
3) The method is effective: symptom improvement, integral reduction is more than or equal to 1/2.
4) Invalidation: no improvement in symptoms and no decrease in score.
5. Statistical treatment
SPSS19.0 statistical software was used. Metering data toRepresenting, row t-test; the count data is expressed in (%), the X2 test is statistically significant with P < 0.05 as the difference.
6. Results
Syndrome analysis finds that the most common syndromes in patients are: qi deficiency and blood stasis. By therapy, it was observed that: the treatment effective rate of the observation group is 95.12 percent higher than that of the control group 75.61 percent (P is less than 0.05); the symptom integral of the two groups of defecation laborious degree, defecation interval time, abdominal pain and abdominal distention degree, fecal property, defecation urgent feeling, inexhaustible degree and the like after treatment is obviously reduced, and the observation group integral is obviously lower than that of the control group (P is less than 0.05); both anxiety scores (HAMA) and depression scores (HAMD) decreased significantly after treatment, and the observed group scores were significantly lower than the control group (P < 0.05); the observed group had a slightly higher incidence of adverse events than the control group of 9.68% at 11.30%, but the differences were not statistically significant (P < 0.05).
In conclusion, the traditional Chinese medicine composition disclosed by the invention has an exact curative effect on constipation after the spine fracture, can obviously improve clinical symptoms and negative emotion of a patient, promotes defecation, is safe and effective, and has practical popularization and application values.
Claims (10)
1. A traditional Chinese medicine composition for preventing and/or treating constipation is characterized in that: the material is prepared from the following raw materials in parts by weight:
5 to 25 parts of cistanche, 1 to 10 parts of cinnamon, 5 to 25 parts of mulberry, 1 to 10 parts of rhizoma polygonati, 5 to 25 parts of astragalus, 1 to 10 parts of cimicifuga foetida, 1 to 10 parts of fructus aurantii immaturus, 1 to 10 parts of snakegourd fruit, 5 to 25 parts of angelica, 5 to 25 parts of peach kernel and 1 to 10 parts of jujube.
2. The traditional Chinese medicine composition according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
7-13 parts of cistanche, 2-8 parts of cinnamon, 7-13 parts of mulberry, 2-8 parts of rhizoma polygonati, 7-13 parts of astragalus, 2-8 parts of cimicifuga foetida, 2-8 parts of fructus aurantii immaturus, 2-8 parts of snakegourd fruit, 7-13 parts of angelica sinensis, 7-13 parts of peach kernel and 2-8 parts of jujube.
3. The traditional Chinese medicine composition according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
10 parts of cistanche, 5 parts of cinnamon, 10 parts of mulberry, 5 parts of rhizoma polygonati, 10 parts of astragalus, 5 parts of cimicifuga foetida, 5 parts of fructus aurantii immaturus, 5 parts of snakegourd fruit, 10 parts of angelica sinensis, 10 parts of peach kernel and 5 parts of jujube.
4. A composition according to any one of claims 1 to 3, characterized in that: the preparation is prepared by taking medicinal powder of raw materials or water or organic solvent extract of the raw materials as active ingredients and adding pharmaceutically acceptable auxiliary materials; the preparation is an oral preparation.
5. The composition of claim 4, wherein: the oral preparation is solution, paste, pill, tablet or granule.
6. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 5, which is characterized in that: it comprises the following steps:
(1) Weighing the raw materials according to the proportion;
(2) Grinding the raw materials into powder, or extracting with water or organic solvent, and adding adjuvants or auxiliary components commonly used in medicine.
7. Use of the Chinese medicinal composition according to any one of claims 1 to 5 in the preparation of a medicament for preventing and/or treating constipation.
8. Use according to claim 7, characterized in that: the medicine is used for treating constipation after fracture, preferably constipation, abdominal distention and defecation weakness caused by qi deficiency and blood stasis after fracture.
9. Use according to claim 8, characterized in that: the medicine has effects of strengthening yang, activating qi-flowing, removing blood stasis, and relaxing bowels.
10. The use of the traditional Chinese medicine composition according to any one of claims 1 to 5 in combination with polyethylene glycol 4000 powder for preparing a medicament for treating constipation, characterized in that: the mass ratio of the traditional Chinese medicine composition to the polyethylene glycol 4000 powder is 49-113: 20, preferably 85:20, a step of; the medicine is used for treating constipation after fracture.
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