CN117392188B - Method and system for magnetocardiographic image registration - Google Patents
Method and system for magnetocardiographic image registration Download PDFInfo
- Publication number
- CN117392188B CN117392188B CN202311329915.2A CN202311329915A CN117392188B CN 117392188 B CN117392188 B CN 117392188B CN 202311329915 A CN202311329915 A CN 202311329915A CN 117392188 B CN117392188 B CN 117392188B
- Authority
- CN
- China
- Prior art keywords
- cardiac
- map
- marker
- heart
- structural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 33
- 230000000747 cardiac effect Effects 0.000 claims abstract description 164
- 239000003550 marker Substances 0.000 claims abstract description 101
- 238000001514 detection method Methods 0.000 claims abstract description 33
- 238000005259 measurement Methods 0.000 claims abstract description 27
- 210000005246 left atrium Anatomy 0.000 claims description 11
- 210000005240 left ventricle Anatomy 0.000 claims description 11
- 210000005245 right atrium Anatomy 0.000 claims description 11
- 210000005241 right ventricle Anatomy 0.000 claims description 11
- 238000012545 processing Methods 0.000 claims description 9
- 210000002837 heart atrium Anatomy 0.000 claims description 7
- 238000013507 mapping Methods 0.000 claims 2
- 238000010586 diagram Methods 0.000 abstract description 11
- 239000000523 sample Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000002604 ultrasonography Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 210000000596 ventricular septum Anatomy 0.000 description 4
- 210000003709 heart valve Anatomy 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 238000000547 structure data Methods 0.000 description 3
- 210000003157 atrial septum Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000002565 electrocardiography Methods 0.000 description 2
- 238000002582 magnetoencephalography Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241001270131 Agaricus moelleri Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
- G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
- A61B5/243—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0883—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
- A61B2560/0228—Operational features of calibration, e.g. protocols for calibrating sensors using calibration standards
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10132—Ultrasound image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30048—Heart; Cardiac
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30204—Marker
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Cardiology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Quality & Reliability (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The present disclosure relates to methods and systems for magnetocardiographic image registration. The method comprises the following steps: acquiring heart structure information of a tested person through B ultrasonic detection, selecting heart structure marking points according to the heart structure information, and attaching heart structure markers to the heart structure marking points; selecting at least two reference mark points on the body surface of the tested person, and attaching the reference mark on the at least two reference mark points; acquiring position information of a cardiac structural marker and a reference marker through three-dimensional scanning to generate a cardiac structural diagram; attaching a reference coil to at least two reference marker points after the cardiac structural marker and the reference marker are removed; performing a magnetocardiogram measurement with the reference coil energized to generate a magnetocardiogram map; and registering the cardiac magnetic field map with the cardiac structural map by matching the position of poles of the reference coil in the cardiac magnetic field map with the position of the reference marker in the cardiac structural map.
Description
Technical Field
The present disclosure relates to the field of medical devices, and in particular to a method and system for magnetocardiographic image registration.
Background
Magnetocardiography (Magnetoencephalography, MEG) is a technique that does not have a nondestructive, noninvasive, non-radiative detection of cardiac electromagnetic function. The electrical activity of the heart generates a magnetic field due to the movement of charged particles between the cardiac myocytes, which is measured and recorded by a magnetocardiograph using a highly sensitive magnetic sensor. Unlike an electrocardiogram (Electrocardiography, ECG), magnetocardiogram measures magnetic fields rather than electric fields, and thus can provide additional information about cardiac electrical activity. In addition, magnetocardiography is a non-invasive detection method that is widely used to study the nature, rhythm, and abnormalities of cardiac electrical activity. The magnetocardiogram can also plan and guide cardiac surgery prior to surgery, as well as evaluate the effect of drug therapy.
By the magnetocardiogram measurement, a magnetic cardiac field distribution map generated by the electrical activity of the heart, which can reflect information of the electrical activity of the subject, can be obtained. However, the heart structure of the subject tends to be different due to individual differences. In the prior art, the heart structure condition of a subject cannot be intuitively reflected in heart magnetic field data obtained by magnetocardiography, so that the heart condition of the subject may not be accurately judged. It is therefore an important topic and research direction in the art how to provide a method and system that can register a magnetocardiogram image that combines magnetocardiogram data obtained from magnetocardiogram measurements with structural cardiac data.
Disclosure of Invention
According to an aspect of the present disclosure, there is provided a method for magnetocardiographic image registration, comprising: acquiring heart structure information of a tested person through B ultrasonic detection, selecting heart structure marking points according to the heart structure information, and attaching heart structure markers to the heart structure marking points; selecting at least two reference mark points on the body surface of the tested person, and attaching the reference mark on the at least two reference mark points; acquiring position information of a cardiac structural marker and a reference marker through three-dimensional scanning to generate a cardiac structural diagram; attaching a reference coil to at least two reference marker points after the cardiac structural marker and the reference marker are removed; performing a magnetocardiogram measurement with the reference coil energized to generate a magnetocardiogram map; and registering the cardiac magnetic field map with the cardiac structural map by matching the position of poles of the reference coil in the cardiac magnetic field map with the position of the reference marker in the cardiac structural map.
In some embodiments, the cardiac structural information may include the shape and location of at least one or more of the following: the heart contours, the boundaries between the left atrium and the right atrium, the boundaries between the left ventricle and the right ventricle, the boundaries between the left atrium and the left ventricle, and the boundaries between the right atrium and the right ventricle.
In some embodiments, the cardiac structure marker points may be evenly distributed over positions corresponding to the contours of the heart and the boundaries of the atria and ventricles based on the cardiac structure information.
In some embodiments, each of the at least two reference marker points may be a point in the cardiac structure marker points or a point outside the cardiac structure marker points, and the at least two reference marker points may be located within a magnetic field detection range of the magnetocardiography measurements.
In some embodiments, the cardiac structural markers and the reference markers may be between 3mm and 10mm in diameter.
In some embodiments, the reference coil is connected to a power source, which may provide a current signal to the reference coil when the magnetocardiographic measurements are made, such that a magnetic field is generated at the reference coil.
In some embodiments, the frequency of the current signal may be greater than 45Hz.
In some embodiments, generating the cardiac structure map may include: the position information of the cardiac structural markers and the reference markers is mapped onto a plane parallel to the plane on which the subject lies to obtain a two-dimensional structural coordinate map including the reference marker coordinates and the cardiac structural coordinates.
In some embodiments, registering the cardiac magnetic field map with the cardiac structural map may include: the cardiac magnetic field map is registered with the cardiac structure map on a scale of a ratio of a distance between poles of reference coils in the cardiac magnetic field map to a distance between reference markers in the cardiac structure map.
According to another aspect of the present disclosure, there is provided a system for magnetocardiographic image registration, comprising: the B ultrasonic detection device is configured to acquire heart structure information of a tested person; the heart structure marker is attached to heart structure marker points selected according to the heart structure information, and the reference marker is attached to at least two reference marker points on the body surface of the tested person; a three-dimensional scanning device configured to acquire positional information of the cardiac structural markers and the reference markers to generate a cardiac structural map; and a reference coil attached to at least two reference marker points after the cardiac structural marker and the reference marker are removed; a magnetocardiographic measurement device configured to make magnetocardiographic measurements with the reference coil energized to generate a magnetocardiographic map; and a data processing unit configured to match the position of the poles of the reference coil in the cardiac magnetic field map with the position of the reference marker in the cardiac structure map to register the cardiac magnetic field map with the cardiac structure map.
In some embodiments, the three-dimensional scanning device may be a handheld three-dimensional scanner.
In some embodiments, the system may further comprise a display unit configured to display a coupled image of the cardiac magnetic field map registered with the cardiac structural map.
The present disclosure provides a method and system for magnetocardiographic image registration combining B-ultrasound detection with magnetocardiography measurements, which can combine the data of cardiac structure obtained by B-ultrasound with the data of magnetic cardiac field obtained by magnetocardiography measurements, thereby obtaining a coupled image of cardiac structure corresponding to magnetic cardiac field, which can intuitively reflect both the condition of cardiac structure and the distribution of magnetic cardiac field to facilitate the detection of, for example, structural lesions of the heart. In addition, the method and the system disclosed by the invention use the B-ultrasonic detection technology to obtain the heart structure data, and have the advantages of no wound, no radiation, simple operation, easy data processing and the like compared with detection modes such as CT and the like.
It should be understood that the description in this section is not intended to identify key or critical features of the embodiments of the disclosure, nor is it intended to be used to limit the scope of the disclosure. Other features of the present disclosure will become apparent from the following specification.
Drawings
The accompanying drawings illustrate exemplary embodiments and, together with the description, serve to explain exemplary implementations of the embodiments. The illustrated embodiments are for exemplary purposes only and do not limit the scope of the claims. Throughout the drawings, identical reference numerals designate similar, but not necessarily identical, elements.
The above and other features and advantages of the present disclosure will become more apparent to those of ordinary skill in the art by describing in detail embodiments thereof with reference to the attached drawings, in which:
FIG. 1 shows a schematic diagram of the upper body and heart structure of a subject in a normal case;
FIG. 2 illustrates a flow chart of a method for magnetocardiographic image registration according to an embodiment of the disclosure;
FIG. 3A shows a schematic view of a cardiac structural marker attached to a body surface of a subject in accordance with an embodiment of the present disclosure;
FIG. 3B shows a schematic view of a cardiac structural marker and a reference marker attached to a body surface of a subject in accordance with an embodiment of the present disclosure;
FIG. 3C shows a schematic view of a reference coil attached to a body surface of a subject in accordance with an embodiment of the present disclosure;
FIG. 4A shows a schematic diagram of a cardiac magnetic field map including an image of poles of a reference coil, according to an embodiment of the present disclosure;
FIG. 4B shows a schematic diagram of a coupled image of a cardiac magnetic field map registered with a cardiac structural map in accordance with an embodiment of the present disclosure; and
Fig. 5 shows a block diagram of a system for magnetocardiographic image registration according to an embodiment of the disclosure.
Detailed Description
Exemplary embodiments of the present disclosure are described below in conjunction with the accompanying drawings, which include various details of the embodiments of the present disclosure to facilitate understanding, and should be considered as merely exemplary. Accordingly, one of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope of the present disclosure. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.
In the present disclosure, the use of the terms "first," "second," and the like to describe various elements is not intended to limit the positional relationship, timing relationship, or importance relationship of the elements, unless otherwise indicated, and such terms are merely used to distinguish one element from another. In some examples, a first element and a second element may refer to the same instance of the element, and in some cases, they may also refer to different instances based on the description of the context.
The terminology used in the description of the various illustrated examples in this disclosure is for the purpose of describing particular examples only and is not intended to be limiting. Unless the context clearly indicates otherwise, the elements may be one or more if the number of the elements is not specifically limited. Furthermore, the term "and/or" as used in this disclosure encompasses any and all possible combinations of the listed items.
Magnetocardiographic measurement techniques utilize highly sensitive magnetic sensors to measure and record the magnetic fields generated by the electrical activity of the heart. By means of the magnetocardiogram measurement, a magnetic field distribution map of the heart reflecting the information of the electrocardiographic activity of the subject can be obtained. However, the heart structure of the subject tends to be different due to individual differences. In the prior art, the heart structure condition of a subject cannot be intuitively reflected in heart magnetic field data obtained by magnetocardiography, so that the heart condition of the subject may not be accurately judged.
In view of this, the present disclosure provides a method and system for magnetocardiographic image registration that combines B-mode detection with magnetocardiography measurements, which is capable of combining cardiac structure data obtained by B-mode with magnetic field data obtained by magnetocardiography measurements, thereby obtaining a coupled image of the cardiac structure corresponding to the magnetic field of the heart to facilitate detection of, for example, structural lesions of the heart. In addition, the method and the system disclosed by the invention use the B-ultrasonic detection technology to obtain the heart structure data, and have the advantages of no wound, no radiation, simple operation, easy data processing and the like compared with detection modes such as CT and the like.
Embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings.
Fig. 1 shows a schematic diagram of the upper body and heart structure of a subject in a normal case. The heart is one of the major organs of the human body, and is normally located mostly in the left thoracic cavity, the main function of which is to power blood flow. Generally, the general structure of the heart is primarily defined by the contours of the heart, the atrial septum, the ventricular septum, and the shape and location of the valve. As shown in fig. 1, the heart is divided by the heart space (including the septum and the septum) into left and right parts, which in turn are each divided by heart valves into a right atrium a, a right ventricle b, a left atrium c, and a left ventricle d. In the heart structure schematic shown in fig. 1, the boundary between the right atrium a and the left atrium c may be defined by the ventricular septum, the boundary between the right ventricle b and the left ventricle d may be defined by the ventricular septum, and the boundary between the right atrium a and the right ventricle b and the boundary between the left atrium c and the left ventricle d may be defined by the heart valve.
Next, a method for magnetocardiographic image registration according to an embodiment of the present disclosure is described with reference to fig. 2, 3A-3C, and 4A-4B based on the heart structure of a subject in the normal case shown in fig. 1.
Fig. 2 shows a flowchart of a method 100 for magnetocardiographic image registration according to an embodiment of the disclosure. As shown in fig. 2, the method 100 may include:
Step S110: acquiring heart structure information of a tested person through B ultrasonic detection, selecting a heart structure marking point P according to the heart structure information, and attaching a heart structure marker 221 to the heart structure marking point P;
Step S120: selecting at least two reference mark points R on the body surface of a tested person, and attaching a reference mark 222 to the at least two reference mark points R;
Step S130: acquiring positional information of the cardiac structural markers 221 and the reference markers 222 by three-dimensional scanning to generate a cardiac structural map;
Step S140: attaching a reference coil 240 to the at least two reference marker points R after the cardiac structural markers 221 and the reference markers 222 are removed;
Step S150: performing a magnetocardiogram measurement with the reference coil 240 energized to generate a magnetocardiogram map; and
Step S160: the cardiac magnetic field map is registered with the cardiac structure map by matching the position of the poles of the reference coil 240 in the cardiac magnetic field map with the position of the reference marker 222 in the cardiac structure map.
In step S110, heart structure information of the subject is acquired using B-mode ultrasonic detection. B ultrasonic, i.e. B-type ultrasonic detection technology, uses the characteristics of ultrasonic waves to image, and is commonly used for detecting the structure, function and abnormal condition of internal tissues and organs of a human body. As the ultrasound propagates to different tissue or organ interfaces, reflections, refractions, and propagates, changes in these sound waves are captured by the probe and converted into images. Different tissues and organs have different reflection degrees on ultrasonic waves, so that images with different gray scales can be generated, and the structure and the characteristics of the tissues are displayed. Compared with other detection modes, the B-ultrasonic detection has the advantages that as a non-invasive and non-radiative detection method, no operation or penetration into a body is needed, and the detection is performed through a probe on the surface of the skin, so that no physical damage is caused to a patient. In addition, the B-ultrasound technique can provide real-time images and the physician can view changes in the internal structure of the patient, such as the heart, on a screen.
In performing the test according to the method of the embodiments of the present disclosure, the subject may lie flat on a flat test bed. In step S110, the B-mode ultrasonic detection device may search and confirm the outline of the heart and the boundary of the atrium and ventricle by moving the position of the B-mode ultrasonic probe perpendicular to the bed surface of the detection bed by collecting the heart structure information on the body surface of the subject using the B-mode ultrasonic. When the B-ultrasonic probe finds the positions of the heart outline and the boundary of the atrium and the ventricle, the body surface position of the tested person where the B-ultrasonic probe is positioned is selected as a heart structure marking point P, and the heart structure marker 221 is attached to the heart structure marking point P. In some examples, the B-ultrasound probe may be a phased array probe adapted to scan the entire heart through the intercostal space. The B-ultrasonic probe may be other types of probes such as a convex probe, a linear probe, etc., depending on the actual detection situation.
According to some embodiments, the cardiac structural information may include the shape and location of at least one or more of: the heart contours, the boundaries between the left atrium and the right atrium, the boundaries between the left ventricle and the right ventricle, the boundaries between the left atrium and the left ventricle, and the boundaries between the right atrium and the right ventricle are chosen to facilitate selection of heart structure marker points from the heart structure information that are capable of marking the general structure of the heart, including the heart contours and the boundaries of the atrium and the ventricle. In some examples, the boundary between the left atrium and the right atrium may be defined by the atrial septum of the heart, the boundary between the left ventricle and the right ventricle may be defined by the ventricular septum of the heart, the boundary between the right atrium and the right ventricle, and the boundary between the left atrium and the left ventricle may be defined by the heart valve of the heart.
Fig. 3A shows a schematic view of a cardiac structural marker 221 attached to a body surface of a subject according to an embodiment of the present disclosure. As shown in fig. 3A, according to some embodiments, the cardiac structure marking points P may be uniformly distributed at positions corresponding to the cardiac contours and the boundaries of the atria and ventricles, so that the lines of the cardiac structure markers 221 attached to the cardiac structure marking points P can clearly and accurately trace the cardiac contours and the boundaries of the atria and ventricles to mark the cardiac structure. The number of cardiac structure marker points P and corresponding cardiac structure markers 221 is not particularly limited as long as the cardiac structure can be clearly and accurately marked.
After the cardiac structural markers 221 are attached to the body surface of the subject, at step S120, at least two reference mark points R are selected on the body surface of the subject, and the reference markers 222 are attached to the at least two reference mark points R. According to some embodiments, each of the at least two reference marker points R is a point in the cardiac structure marker point P (i.e. may coincide with a point in the cardiac structure marker point P) or is a point outside the cardiac structure marker point P (i.e. does not coincide with a point in the cardiac structure marker point P), and the at least two reference marker points are located within the magnetic field detection range of the subsequently performed magnetocardiography measurements. Fig. 3B shows a schematic view of a cardiac structural marker 221 and a reference marker 222 attached to a body surface of a subject according to an embodiment of the present disclosure. For convenience of description and understanding, only a case where at least two reference mark points R are at least two points other than the heart structure mark point P is shown in fig. 3B, it is conceivable that the selected reference mark point R may also coincide with the heart structure mark point P.
According to some embodiments, the cardiac structural markers 221 and the reference markers 222 may be between 3mm and 10mm in diameter. By using markers in this size range, the heart structure can be labeled more accurately without the need to employ an excessive number of markers. In some examples, the cardiac structural markers 221 and the reference markers 222 may be between 7mm and 8mm in diameter. The shape and size of the reference marker 222 may be the same as or different from the shape and size of the cardiac structural marker 221, depending on the actual situation. In some examples, cardiac structural markers 221 and reference markers 222 may be markers such as circular, and are not limited thereto.
Subsequently, in step S130, positional information of the cardiac structural marker 221 and the reference marker 222 is acquired by three-dimensional scanning to generate a cardiac structural map. Three-dimensional scanning is a technique of scanning the spatial shape and structure and color of an object by, for example, laser light to obtain spatial coordinates of the object surface, and in a method according to an embodiment of the present disclosure, spatial position information of a cardiac structure marker 221 and a reference marker 222 attached to a cardiac structure marker point P and a reference marker point R on the body surface of a subject, respectively, is obtained by three-dimensional scanning, and then the position information is processed to generate a cardiac structure map including cardiac structure positions corresponding to the cardiac structure marker point P and reference marker positions corresponding to the reference marker point R.
According to some embodiments, generating the cardiac structure map may include: the position information of the cardiac structure marker 221 and the reference marker 222 is mapped onto a plane parallel to the plane on which the subject lies, and an appropriate origin is selected to construct a coordinate system to obtain a two-dimensional structure coordinate map including reference mark coordinates corresponding to the reference mark point R and cardiac structure coordinates corresponding to the cardiac structure mark point P.
Next, in step S140, after the cardiac structural marker 221 and the reference marker 222 are removed, the reference coil 240 is attached to the at least two reference marker points R. Fig. 3C shows a schematic diagram of a reference coil 240 attached to a body surface of a subject, the reference coil 240 being located on the at least two reference mark points R in the same position as the reference mark 222, according to an embodiment of the present disclosure.
In step S150, a magnetocardiogram measurement is performed with the reference coil 240 energized to generate a magnetocardiogram map. Fig. 4A shows a schematic diagram of a cardiac magnetic field map including an image of poles of reference coil 240, the cardiac magnetic field map showing magnetic fields generated by cardiac electrical activity and magnetic fields generated by energized reference coil 240, poles of the magnetic field generated by reference coil 240 being located at positions corresponding to reference mark point R, according to an embodiment of the present disclosure.
According to some embodiments, the reference coil 240 is connected to a power source that provides a current signal to the reference coil 240 when the magnetocardiographic measurements are made, such that a magnetic field is generated at the reference coil 240. In the magnetocardiography measurement, the magnetic field signal of the heart is derived from the space magnetic field generated by the ion flow of the myocardial cells of the human body, the frequency of the magnetic field signal is relatively low, and the reference coil 240 electrified by the current generates the magnetic field signal with higher frequency, and the frequency of the magnetic field signal of the coil is greatly different from the frequency of the magnetic field signal of the heart, so that the formation of magnetocardiography images of the heart is not affected. According to some embodiments, the frequency of the current signal provided by the power supply to the reference coil may be greater than 45Hz. When the frequency of the current signal is greater than 45Hz, the frequency of the coil magnetic field does not coincide with the frequency of the heart magnetic field, so that the formation of a heart magnetic image of the heart is not affected. In some examples, to exclude interference from power frequencies, the frequency of the current signal is not 50Hz or 60Hz, e.g., the frequency of the current signal may be greater than 100Hz.
Thereafter, in step S160, the cardiac magnetic field map is registered with the cardiac structure map by matching the position of the poles of the reference coil 240 in the cardiac magnetic field map with the position of the reference marker 222 in the cardiac structure map. Fig. 4B shows a schematic diagram of a coupled image of a cardiac magnetic field map registered with a cardiac structural map in accordance with an embodiment of the present disclosure. Since the reference coil 240 and the reference marker 222 are both located at the same at least two reference marker points R, by matching the position of the poles of the reference coil 240 in the magnetic field map of the heart with the position of the reference marker 222 in the structure map of the heart, the magnetic field map of the heart can be registered with the structure map, resulting in a coupled image as shown in fig. 4B.
According to some embodiments, registering the cardiac magnetic field map with the cardiac structural map may include: the cardiac magnetic field map is registered with the cardiac structure map on a scale of the ratio of the distance d2 between poles of the reference coil 224 in the cardiac magnetic field map to the distance d1 between the reference markers 222 in the cardiac structure map. For example, in the case where the cardiac structure map is a two-dimensional structure coordinate map obtained by processing the position information of the cardiac structure marker 221 and the reference marker 222, the cardiac structure coordinates corresponding to the cardiac structure marker may be adjusted according to the scale and mapped to the cardiac magnetic field map.
The method for magnetocardiography image registration according to the embodiment of the disclosure combines B-mode ultrasonic detection with magnetocardiography measurement to register a magnetic field map of the heart with a structure map of the heart, thereby obtaining a coupled image capable of intuitively reflecting the heart structure and the magnetic field of the heart at the same time to facilitate detection of, for example, structural lesions of the heart.
Fig. 5 shows a block diagram of a system 200 for magnetocardiographic image registration according to an embodiment of the disclosure. The system 200 may implement the method 100 for magnetocardiographic image registration according to an embodiment of the disclosure.
As shown in fig. 5, a system 200 for magnetocardiographic image registration may include: the B-ultrasonic detection device 210, the B-ultrasonic detection device 210 being configured to acquire heart structure information of the subject; a cardiac structure marker 221 and a reference marker 222, the cardiac structure marker 221 being attached to a cardiac structure marker point P selected according to cardiac structure information, the reference marker 222 being attached to at least two reference marker points R on the body surface of the subject; a three-dimensional scanning device 230, the three-dimensional scanning device 230 being configured to acquire positional information of the cardiac structural marker 221 and the reference marker 222 to generate a cardiac structural map; and a reference coil 240, the reference coil 240 being attached to at least two reference mark points R after the heart structural markers 221 and 222 are removed; a magnetocardiographic measurement device 250, the magnetocardiographic measurement device 250 being configured to make magnetocardiographic measurements with the reference coil 240 energized to generate a magnetocardiogram; and a data processing unit 260, the data processing unit 260 being configured to match the position of the poles of the reference coil in the cardiac magnetic field map with the position of the reference marker in the cardiac structure map to register the cardiac magnetic field map with the cardiac structure map. In some examples, the data processing unit 260 may be a separate module. It is conceivable that the data processing unit 260 may also be comprised in, for example, the three-dimensional scanning device 230 or the magnetocardiographic measuring device 250.
It should be appreciated that the various devices and components of the system 200 shown in fig. 5 may correspond to the various steps in the method 100 described with reference to fig. 2. Thus, the operations, features, and advantages described above with respect to method 100 are equally applicable to system 200 and the devices and components that it includes. For brevity, certain operations, features and advantages are not described in detail herein.
According to some embodiments, the three-dimensional scanning device 230 in the system 200 may be a handheld three-dimensional scanner. The hand-held three-dimensional scanner has the advantages of portability, no need of fixed installation, high scanning speed, and the like, and can recognize the cardiac structural markers 221 and the reference markers 222 attached to the body surface of the subject with high accuracy and high resolution. The three-dimensional scanning device can also be other types of three-dimensional scanning devices according to actual detection conditions.
According to some embodiments, the system 200 may further comprise a display unit 270, the display unit 270 being configured to display a coupled image of the cardiac magnetic field map registered with the cardiac structural map, for example as shown in fig. 4B. In some examples, the display unit 270 may be a separate module. It is contemplated that the display unit 270 may also be included in, for example, the three-dimensional scanning device 230 or the magnetocardiographic measurement device 250.
Although embodiments or examples of the present disclosure have been described with reference to the accompanying drawings, it is to be understood that the foregoing methods, systems, and apparatus are merely exemplary embodiments or examples, and that the scope of the present invention is not limited by these embodiments or examples but only by the claims following the grant and their equivalents. Various elements of the embodiments or examples may be omitted or replaced with equivalent elements thereof. Furthermore, the steps may be performed in a different order than described in the present disclosure. Further, various elements of the embodiments or examples may be combined in various ways. It is important that as technology evolves, many of the elements described herein may be replaced by equivalent elements that appear after the disclosure.
Claims (11)
1. A method for magnetocardiographic image registration, comprising:
Acquiring heart structure information of a tested person through B ultrasonic detection, selecting heart structure marking points according to the heart structure information, and attaching heart structure markers to the heart structure marking points;
selecting at least two reference mark points on the body surface of the tested person, and attaching a reference mark to the at least two reference mark points;
Acquiring position information of the cardiac structural marker and the reference marker by three-dimensional scanning to generate a cardiac structure map, wherein generating the cardiac structure map comprises: mapping the position information of the cardiac structural markers and the reference markers onto a plane parallel to the plane on which the subject lies to obtain a two-dimensional structural coordinate map including reference marker coordinates and cardiac structural coordinates;
Attaching a reference coil to the at least two reference marker points after the cardiac structural marker and the reference marker are removed;
performing a magnetocardiogram measurement with the reference coil energized to generate a magnetocardiogram map; and
The cardiac magnetic field map is registered with the cardiac structure map by matching the position of poles of the reference coil in the cardiac magnetic field map with the position of the reference marker in the cardiac structure map.
2. The method of claim 1, wherein the cardiac structural information includes a shape and location of at least one or more of: the heart contours, the boundaries between the left atrium and the right atrium, the boundaries between the left ventricle and the right ventricle, the boundaries between the left atrium and the left ventricle, and the boundaries between the right atrium and the right ventricle.
3. The method according to claim 1 or 2, wherein the cardiac structure marker points are evenly distributed over positions corresponding to the cardiac contours and the boundaries of the atrium and ventricle, based on the cardiac structure information.
4. The method according to claim 1 or 2, wherein each of the at least two reference marker points is a point of the cardiac structure marker points or a point outside the cardiac structure marker points, and the at least two reference marker points are located within a magnetic field detection range of the magnetocardiography measurements.
5. The method of claim 1 or 2, wherein the cardiac structural marker and the reference marker are between 3mm and 10mm in diameter.
6. The method of claim 1 or 2, wherein the reference coil is connected to a power source that provides a current signal to the reference coil when the magnetocardiographic measurements are taken, such that a magnetic field is generated at the reference coil.
7. The method of claim 6, wherein the frequency of the current signal is greater than 45Hz.
8. The method of claim 1 or 2, wherein registering the cardiac magnetic field map with the cardiac structural map comprises: registering the cardiac magnetic field map with the cardiac structure map on a scale of a ratio of a distance between poles of the reference coils in the cardiac magnetic field map to a distance between the reference markers in the cardiac structure map.
9. A system for magnetocardiographic image registration, comprising:
The B-ultrasonic detection device is configured to acquire heart structure information of a tested person;
The heart structure marker is attached to heart structure marker points selected according to the heart structure information, and the reference marker is attached to at least two reference marker points on the body surface of the tested person;
a three-dimensional scanning device configured to acquire positional information of a cardiac structural marker and a reference marker to generate a cardiac structure map, wherein generating the cardiac structure map comprises: mapping the position information of the cardiac structural markers and the reference markers onto a plane parallel to the plane on which the subject lies to obtain a two-dimensional structural coordinate map including reference marker coordinates and cardiac structural coordinates; and
A reference coil attached to the at least two reference marker points after the cardiac structural marker and the reference marker are removed;
a magnetocardiogram measuring device configured to make magnetocardiogram measurements with the reference coil energized to generate a magnetocardiogram map; and
A data processing unit configured to match a position of a pole of the reference coil in the cardiac magnetic field map with a position of the reference marker in the cardiac structural map to register the cardiac magnetic field map with the cardiac structural map.
10. The system of claim 9, wherein the three-dimensional scanning device is a handheld three-dimensional scanner.
11. The system of claim 9 or 10, wherein the system further comprises a display unit configured to display a coupled image of the cardiac magnetic field map registered with the cardiac structural map.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311329915.2A CN117392188B (en) | 2023-10-13 | 2023-10-13 | Method and system for magnetocardiographic image registration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311329915.2A CN117392188B (en) | 2023-10-13 | 2023-10-13 | Method and system for magnetocardiographic image registration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117392188A CN117392188A (en) | 2024-01-12 |
| CN117392188B true CN117392188B (en) | 2024-05-28 |
Family
ID=89471412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311329915.2A Active CN117392188B (en) | 2023-10-13 | 2023-10-13 | Method and system for magnetocardiographic image registration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117392188B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112957048A (en) * | 2021-03-23 | 2021-06-15 | 北京未磁科技有限公司 | Position adjusting device for adjusting position of detection equipment and magnetocardiogram instrument |
| CN115956914A (en) * | 2022-12-22 | 2023-04-14 | 北京航空航天大学 | CT and SERF-based magnetocardiogram imaging registration system and method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1769741B1 (en) * | 2004-06-01 | 2013-05-29 | National University Corporation Iwate University | Cardiac magnetic field diagnostic apparatus and damaged cardiac muscle three-dimensional localization evaluating method |
-
2023
- 2023-10-13 CN CN202311329915.2A patent/CN117392188B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112957048A (en) * | 2021-03-23 | 2021-06-15 | 北京未磁科技有限公司 | Position adjusting device for adjusting position of detection equipment and magnetocardiogram instrument |
| CN115956914A (en) * | 2022-12-22 | 2023-04-14 | 北京航空航天大学 | CT and SERF-based magnetocardiogram imaging registration system and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117392188A (en) | 2024-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7047016B2 (en) | Alignment map using intracardiac signal | |
| US20210153843A1 (en) | Devices and methods for determination of electrical dipole densities on a cardiac surface | |
| JP4758355B2 (en) | System for guiding medical equipment into a patient's body | |
| JP6430498B2 (en) | System and method for mapping of ultrasonic shear wave elastography measurements | |
| CN110537961B (en) | Minimally invasive intervention guiding system and method for CT and ultrasonic image fusion | |
| US10639004B2 (en) | Method and apparatus for localizing an ultrasound catheter | |
| US8057390B2 (en) | High-resolution mapping of bio-electric fields | |
| CN1853574B (en) | Registration of ultrasound data with pre-acquired image | |
| CN1853573B (en) | Using Ultrasound to acquire image registration electro-anatomical map | |
| US5817029A (en) | Spatial measurement of EEG electrodes | |
| US20080234570A1 (en) | System For Guiding a Medical Instrument in a Patient Body | |
| KR20070026135A (en) | Segmentation and registration of multimodal images using physiological data | |
| US20070244369A1 (en) | Medical Imaging System for Mapping a Structure in a Patient's Body | |
| CN116473566A (en) | Imaging to determine electrode geometry | |
| US20090287089A1 (en) | Methods, devices and apparatus for imaging for reconstructing a 3-D image of an area of interest | |
| RU2550660C2 (en) | Device and method of non-invasive intracardial electrocardiography with formation of image with application of magnetic particles | |
| EP3563763B1 (en) | Improved active voltage location (avl) resolution | |
| CA2988766C (en) | Non-invasive system and method of spatial localization of specific electrocardiac elements | |
| US20140088404A1 (en) | Patient positioning device, and medical imaging method and apparatus employing same | |
| CN117392188B (en) | Method and system for magnetocardiographic image registration | |
| US11344239B2 (en) | Non-invasive system and method of spatial localization of specific electrocardiac elements | |
| Peterhans et al. | A fully automatic calibration framework for navigated ultrasound imaging | |
| TWI852356B (en) | Ultrasound imaging system | |
| JP7385217B2 (en) | Biocurrent estimation method, biocurrent estimation device, and biomagnetic measurement system | |
| JP3233444B2 (en) | Biomagnetism measuring device, biomagnetism measuring method, and mounting device for biomagnetism measuring device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20240112 Assignee: Beijing Weici Medical Technology Co.,Ltd. Assignor: Beijing Weici Technology Co.,Ltd. Contract record no.: X2024990000071 Denomination of invention: Methods and systems for cardiac magnetic image registration License type: Common License Record date: 20240208 |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |