CN117334305A - Automatic and intelligent control system and method for microscope pathology diagnosis process - Google Patents
Automatic and intelligent control system and method for microscope pathology diagnosis process Download PDFInfo
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
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Abstract
The invention discloses a microscope pathological diagnosis flow automation and intelligent control system and method, the system includes: the system comprises a sample identification system, a sample intelligent movement and automatic focusing system, an image real-time display and image editing system, a shared diagnosis system, a pathology diagnosis data review and comparison diagnosis system, a pathology report writing system and a sample storage management system. The invention can realize automation of the key steps of position movement, automatic focusing, real-time image display and the like of the sample under the microscope, thus improving the working efficiency and accuracy of the process of diagnosing pathological sections by the microscope, reducing the workload of doctors and operators, and simultaneously providing clear sample images for the doctors to carry out pathological diagnosis and analysis, thereby further improving the accuracy of diagnosis.
Description
Technical Field
The invention relates to the technical field of biological microscopes, in particular to an automatic and intelligent control system for a microscope pathological diagnosis process.
Background
Cytological examination or histological examination, by taking a tumor tissue sample or cell sample for microscopic observation and cytological analysis, the presence of a tumor, the type and nature of the tumor can be further confirmed. The whole diagnosis process involves the following procedures: receiving a sample and registering numbering information; observing the structure and the form of the sample under a microscope; according to the pathological changes of the samples, doctors carry out consultation, consult relevant pathological diagnosis auxiliary data, carry out comprehensive judgment and differential diagnosis, and determine the disease type and the disease severity; recording the diagnosis result in a pathology report by a doctor, and writing a diagnosis report; finally, the sample is stored, and the sample number is manually registered to perform sample storage management.
The processes of sample information registration, microscope observation sample adjustment, diagnosis of pathological diagnosis, diagnosis report writing, sample storage management and the like relate to independent individual operation, and do not form a systematic automatic flow. More human participation is needed between the processes to complete the whole process, time and labor cost are wasted, and the risk of possible mistakes of personnel exists.
Disclosure of Invention
Based on the above, it is necessary to provide a control system for automating and intelligentizing the microscopic pathological diagnosis process.
A control system for automating and intellectualizing a microscopic pathology diagnosis procedure, comprising:
the sample identification system is used for identifying the coding information of the sample, and is also used for identifying the position of the sample on a glass slide of a microscope and constructing a focusing curved surface of the sample;
the sample intelligent movement and automatic focusing system is used for driving the sample to move under the microscope and is also used for automatically focusing the sample under the microscope;
the image real-time display and image editing system is used for displaying sample images observed by a microscope in real time and editing and analyzing the sample images;
the shared diagnosis system is used for sharing the diagnosis results and experiences of different doctors;
the pathognomonic data consulting and comparing diagnosis system is used for providing reference data and pathological image data required by doctor diagnosis and can automatically assist diagnosis;
the pathology report writing system is used for automatically generating a pathology report according to the pathological diagnosis conclusion of a doctor;
and the sample storage management system is used for automatically establishing a database for the samples after diagnosis by the doctor.
In one embodiment, the sample identification system comprises:
the code identification module is used for reading and analyzing the code information on the sample;
the sample area identification module is used for positioning and identifying the position of each sample on the slide and calculating the position coordinates of the samples;
and the focusing curved surface construction module is used for automatically arranging a corresponding number of focusing points in the area in the identification edge of the sample, automatically focusing each focusing point and constructing the focusing curved surface of the sample through a software algorithm.
In one embodiment, the code information is coded as an identification code or a two-dimensional code, and the code information includes a personal identification number, a medical record number, a sample type and a department of care of the patient.
In one embodiment, the sample intelligent movement and autofocus system comprises:
the sample intelligent moving module comprises an X-axis motor and a Y-axis motor, wherein the X-axis motor and the Y-axis motor are respectively connected with an X-direction moving platform and a Y-direction moving platform of the microscope, the X-direction moving platform and the Y-direction moving platform are vertically stacked to form an objective table, and a slide is placed on the upper surface of the objective table, wherein the X-axis motor and the Y-axis motor are respectively used for driving the X-direction moving platform and the Y-direction moving platform to move so that a sample moves according to a preset moving path;
the image automatic focusing module comprises a Z-axis motor, and the Z-axis motor can drive an objective lens of the microscope to move up and down to automatically focus the sample.
In one embodiment, the Z-axis motor is disposed on a stand of the microscope, the Z-axis motor is connected to a longitudinal connecting arm, one end of the longitudinal connecting arm is connected to a lateral connecting arm, and the objective lens is disposed on the lateral connecting arm at an end remote from the longitudinal connecting arm, wherein the sample recognition system is disposed on the lateral connecting arm.
In one embodiment, a base is arranged at the bottom of the Y-direction moving platform, and the upright post is fixed on one side of the base.
In one embodiment, the image real-time display and image editing system comprises:
the image real-time display module is connected with the objective lens and is used for transmitting a sample image observed by a microscope to a display screen in real time;
and the image editing module is used for editing the sample image on the display screen.
In one embodiment, the pathognomonic review contrast diagnostic system includes:
a pathology diagnosis data module for integrating reference data of pathology diagnosis;
a pathology image database module for integrating and managing pathology image data;
and the automatic auxiliary diagnosis module is used for automatically performing auxiliary diagnosis on the sample image according to the pathological image data.
In one embodiment, the automatic auxiliary diagnostic module includes:
the primary comparison and data retrieval unit is used for carrying out primary comparison of morphological structures on the sample image and the pathological images in the pathological image database module, and retrieving all pathological images with the similarity of more than 80%;
the high-precision comparison unit is used for sequentially rotating one of the case images by n degrees along the center point of the case image to obtain the similarity between the case images with different angles and the sample image, and selecting the highest value of the similarity as a final similarity value;
and the judging and sorting unit is used for sequentially sorting the final similarity values of all the pathological images with the similarity exceeding 80 percent according to the numerical value.
And the linking unit is used for selecting the first to m pathological images according to the descending order of the final similarity values and automatically linking the first to m pathological images with the pathological diagnosis reference data used in diagnosis.
In one embodiment, the sample storage management system comprises:
the sample storage database module is used for automatically recording the coding information of the samples diagnosed by the doctor according to the sequence number to form sample codes, and the sample codes correspond to the material storage positions of the samples one by one;
the code printing module is used for driving the printer to print corresponding serial number codes on the sample storage boxes, and each sample storage box is provided with a mark consistent with the sample code.
A method of controlling a control system for automating and intellectualizing a microscopic pathology diagnostic procedure, comprising the steps of:
s1, placing a sample to be diagnosed on an objective table of a microscope;
s2, automatically identifying the coding information of the sample and the position of the sample on a glass slide of a microscope;
s3, driving the sample to move under a microscope, and automatically focusing the sample image of the visible region in real time;
s4, transmitting a sample image under a microscope to a display screen for real-time display, and editing and analyzing the sample image;
s5, sharing diagnosis results and experiences of different doctors according to pathological diagnosis requirements;
s6, consulting reference data and pathological image data required by doctor diagnosis, and performing contrast diagnosis and auxiliary diagnosis;
s7, automatically generating a pathology report according to a pathological diagnosis conclusion of a doctor;
s8, automatically establishing a database for the sample after diagnosis by the doctor.
The automatic and intelligent control system for the microscopic pathological diagnosis process can enable the key steps of position movement, automatic focusing, real-time image display and the like of a sample under a microscope to be automated, so that the working efficiency and accuracy of the microscopic pathological section diagnosis process can be improved, the workload of doctors and operators can be reduced, meanwhile, clear sample images can be provided for the doctors to carry out pathological diagnosis and analysis, and the accuracy of diagnosis is further improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a system framework diagram of a control system for automating and intellectualizing the microscopic pathology diagnostic procedure of the present invention;
FIG. 2 is a schematic diagram of the architecture of the control system for automating and intellectualizing the microscopic pathology diagnosis procedure of the present invention;
FIG. 3 is a schematic diagram of the motion structure of the automated and intelligent control system of the microscopic pathology diagnostic process of the present invention;
fig. 4 is a flow chart of a method of the automated and intelligent control system of the microscopic pathology diagnostic process of the present invention.
Detailed Description
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Referring to fig. 1-3, an embodiment of the present invention provides a control system for automating and intelligentizing a microscopic pathology diagnosis process, comprising:
a sample identification system 1 for identifying the encoded information of the sample, the sample identification system 1 being further configured to identify the position of the sample on the slide of the microscope 8 and construct a focusing curved surface of the sample; therefore, accurate reference can be provided for subsequent sample movement, focusing, image acquisition and other operations, and the displayed real-time image can be ensured to be clearer in the movement process of the whole sample.
The sample intelligent movement and automatic focusing system 2 is used for driving the sample to move under the microscope and is also used for automatically focusing the sample under the microscope;
the image real-time display and image editing system 3 is used for displaying a sample image observed by a microscope in real time and editing and analyzing the sample image; for example: the doctor can further observe and analyze the sample image through editing functions such as amplification, measurement, annotation and the like, so that the efficiency and accuracy of pathological diagnosis can be improved.
A shared diagnosis system 4 for sharing diagnosis results and experiences of different doctors; in the embodiment, through the integrated network technology, doctors can access and share the diagnosis results and experiences of the doctors at any time and any place, and can browse and learn the cases and diagnoses of other doctors, so that the quality and the level of pathology can be improved, and a safety platform is provided for remote consultation, teaching demonstration and communication sharing.
The pathognomonic data consulting and comparing diagnosis system 5 is used for providing reference data and pathological image data required by doctor diagnosis and can automatically assist diagnosis; the doctor can review the relevant data in time to perform contrast diagnosis and auxiliary diagnosis, and assist the doctor to make more accurate diagnosis.
A pathology report writing system 6 for automatically generating a pathology report according to the pathological diagnosis conclusion of the doctor; specifically, the pathology report writing system 6 can automatically extract key information and generate a structured report, so that the time and workload of a doctor for writing the report are reduced, and meanwhile, the system is connected with a hospital diagnosis and treatment system, and the report is timely transmitted to a clinician.
And a sample storage management system 7 for automatically creating a database of samples after diagnosis by the doctor. Therefore, errors and complexity of manual registration are reduced, and the sample storage room is convenient to store and manage.
The automatic and intelligent control system for the microscopic pathological diagnosis process can enable the key steps of position movement, automatic focusing, real-time image display and the like of a sample under a microscope to be automated, so that the working efficiency and accuracy of the microscopic pathological section diagnosis process can be improved, the workload of doctors and operators can be reduced, meanwhile, clear sample images can be provided for the doctors to carry out pathological diagnosis and analysis, and the accuracy of diagnosis is further improved.
In one embodiment of the present invention, the sample recognition system 1 includes:
the code identification module 11 is used for reading and analyzing the code information on the sample; in this embodiment, the code of the code information may be an identification code or a two-dimensional code, and the code information includes a personal identification number, a medical record number, a sample type, a department for examination, and the like of the patient. By automatically identifying the coding information, the system can be accurately associated with the medical record data of the patient and the hospital information system, and the pathological diagnosis result is ensured to be accurately corresponding to the identity of the patient.
A sample area identification module 12 for locating and identifying the position of each sample on the slide and calculating the position coordinates of the sample. In particular, the location of each sample on the slide can be located and identified by image processing and analysis techniques. The method can identify the edges and the characteristics of the sample, and calculate the position coordinates of the sample through an algorithm. In this way, the system can accurately determine the area where each sample is located, and provide accurate reference for subsequent operations such as movement, focusing, image acquisition and the like;
and the focusing curved surface construction module 13 is used for automatically arranging a corresponding number of focusing points in the area in the identification edge of the sample, automatically focusing each focusing point and constructing the focusing curved surface of the sample through a software algorithm. Therefore, the whole sample can be ensured to be displayed in a clearer real-time image in the moving process.
In one embodiment of the present invention, the sample intelligent movement and auto-focusing system 2 comprises:
the sample intelligent moving module 21 comprises an X-axis motor 211 and a Y-axis motor 212, wherein the X-axis motor 211 and the Y-axis motor 212 are respectively connected with an X-direction moving platform 81 and a Y-direction moving platform 82 of the microscope 8, the X-direction moving platform 81 and the Y-direction moving platform 82 are vertically stacked to form an objective table, and a glass slide is placed on the upper surface of the objective table, and the X-axis motor 211 and the Y-axis motor 212 are respectively used for driving the X-direction moving platform 81 and the Y-direction moving platform 82 to move so as to enable a sample to move according to a preset moving path;
the image autofocus module 22 includes a Z-axis motor 213, and the Z-axis motor 213 can drive the objective lens 83 of the microscope 8 to move up and down to automatically focus the sample. Thus, by using advanced image processing algorithms and feedback control mechanisms, the distance between the microscope objective and the sample is automatically adjusted according to the characteristics and image quality of the sample, ensuring that a clear, high quality image is obtained. The automatic focusing process not only improves the definition and detail display of the image, but also thoroughly lightens the workload of doctors in focusing, so that the focus of the focus control system can be more focused on observation and analysis of pathological diagnosis.
In this embodiment, the doctor may touch the screen image, or may use a mouse, a joystick, or the like to drive the sample to move intelligently according to the movement path desired by the doctor. The intelligent moving mode greatly improves the working efficiency, so that doctors can browse and analyze different areas in pathological sections more quickly. Specifically, the sample is fixed on the stage, stability of the sample is ensured, and then the X-axis motor 211 and the Y-axis motor 212 receive a movement instruction, and the sample is moved to a designated position according to the instruction. Once the sample reaches the target position, the autofocus definition algorithm sends a command to the Z-axis motor 213 to drive the microscope's objective 83 up and down until a clear image is obtained, which process achieves autofocus to ensure that a clear sample image is observed under the microscope.
In one embodiment of the present invention, the Z-axis motor 213 is disposed on the upright 84 of the microscope 8, the Z-axis motor 213 is connected to a longitudinal connecting arm 85, one end of the longitudinal connecting arm 85 is connected to a lateral connecting arm 86, and the objective lens 83 is disposed on the lateral connecting arm 86 at an end remote from the longitudinal connecting arm 85, wherein the sample recognition system 1 is disposed on the lateral connecting arm 86.
In this embodiment, the Z-axis motor 213 may be fixed at the top of the upright 84, the bottom of the rotating shaft of the Z-axis motor 213 is connected to the bottom of the longitudinal connecting arm 85, and the top of the longitudinal connecting arm 85 is connected to one end of the transverse connecting arm 86, so that the moving space of the objective 83 may be increased, and the use safety is improved.
In an embodiment of the present invention, a base 87 is disposed at the bottom of the Y-direction moving platform 82, and the upright 84 is fixed on one side of the base 87. Wherein the Y-moving stage 82 is slidable along the Y-direction of the base 87 to facilitate adjustment of the Y-direction position of the sample.
In one embodiment of the present invention, the image real-time display and image editing system 3 includes:
the image real-time display module 31 is connected with the objective 83, and the image real-time display module 31 is used for transmitting the sample image observed by the microscope 8 to a display screen in real time; in this embodiment, the system can maintain high definition and accuracy of the image by image acquisition and transmission techniques, and show details and features of the sample to the doctor. The real-time display function is greatly convenient for doctors to observe and analyze samples, so that the doctors can quickly obtain visual information of the samples, and the efficiency of pathological diagnosis is improved. And a more visual and interactive working mode is provided, and meanwhile, the adverse effect on the health caused by a long-term low-head eye-sight microscope of a doctor is also solved.
And the image editing module 32 is used for editing the sample image on the display screen. In this embodiment, the doctor can use the module to perform functional operations such as zooming in, zooming out, measuring the sample size, adding labels, etc. on the image, so that the doctor can observe and analyze in more detail. This flexible image editing capability enables the physician to study the sample more deeply, capturing more subtle changes that aid in diagnosis. Meanwhile, more intelligent assistance is provided for remote consultation, teaching demonstration, communication sharing and the like of pathology by utilizing image editing functions such as amplification, measurement, labeling and the like.
In one embodiment of the present invention, the diagnosis data review and contrast diagnosis system 5 includes:
a pathology diagnosis data module 51 for integrating reference data of pathology diagnosis; in this embodiment, the reference includes related literature, diagnostic criteria, case reports, research results, and the like. The doctor can quickly review and acquire these data by the system for reference and reference during the diagnostic process. The centralized storage and rapid retrieval functions of the data are beneficial to doctors to obtain timely and comprehensive background knowledge and academic support, and the accuracy and reliability of diagnosis are improved.
A pathology image database module 52 for integrating and managing pathology image data. In this embodiment, a physician may view and compare microscope images of different cases through the system to observe and analyze different pathological features, changes and patterns. The construction and application of the image database can help doctors to cultivate, observe and identify pathological images, deepen understanding of disease characteristics and diagnosis points, and improve accuracy and consistency of pathological diagnosis;
the automatic auxiliary diagnosis module 53 is used for automatically auxiliary diagnosing the sample image according to the pathological image data. Therefore, the automatic diagnosis can be carried out on the sample image on the premise of no intervention of manpower, the diagnosis efficiency can be greatly improved, and the reference and the comparison can be provided for the manual diagnosis of doctors.
In one embodiment of the present invention, the automatic auxiliary diagnostic module 53 includes:
the primary comparison and data retrieval unit is used for carrying out primary comparison of morphological structures on the sample image and the pathological images in the pathological image database module, and retrieving all pathological images with the similarity of more than 80%; therefore, pathological pictures which are highly similar to the current sample image in the pathological image database module can be rapidly screened out, so that analysis and diagnosis of the sample image can be conveniently and accurately carried out, wherein the number of the retrieved pathological images can be in a similarity proportion according to actual requirements, for example, the similarity can be 85%, 90% … … and the like.
The high-precision comparison unit is used for sequentially rotating one of the case images by n degrees along the center point of the case image to obtain the similarity between the case images with different angles and the sample image, and selecting the highest value of the similarity as a final similarity value; therefore, the case image can be compared with the sample image in an omnibearing and omnibearing way, so that the problem of dislocation of the case image due to azimuth or angle is avoided, the similarity judgment error with the sample image is increased, and the judgment precision can be improved. Alternatively, n may be a natural integer of 1, 2, 3 … …, etc.
And the judging and sorting unit is used for sequentially sorting the final similarity values of all the pathological images with the similarity exceeding 80 percent according to the numerical value.
And the linking unit is used for selecting the first to m pathological images according to the descending order of the final similarity values and automatically linking the first to m pathological images with the pathological diagnosis reference data used in diagnosis. Alternatively, m may be a natural integer of 2, 3, 4 … …, etc.
In this embodiment, a doctor can quickly and accurately perform final diagnosis on a sample image according to an automatic diagnosis result and combining with his own diagnosis experience, so that the diagnosis efficiency and the diagnosis precision can be improved. Meanwhile, when the doctor selects the first to m pathological images in descending order according to the final similarity value, the related reference data can be automatically triggered to further verify the accuracy of the final diagnosis.
In an embodiment of the present invention, the sample storage management system 7 includes:
the sample storage database module 71 is configured to automatically record the code information of the sample after diagnosis by the doctor according to the sequence number to form a sample code, and correspond to the material storage positions of the sample one by one; therefore, through the query and search functions of the database, doctors can conveniently find the coding information and the storage position of the appointed sample, and the sample warehouse management intellectualization is realized.
The code printing module 72 is configured to drive the printer to print corresponding serial number codes on the sample storage boxes, and each sample storage box is provided with a mark consistent with the sample code. In this way, consistency and correspondence of sample containers to sample codes in the database is ensured. Therefore, when the sample is required to be taken out or returned, a manager can accurately find the corresponding sample information and position only by checking the mark on the sample storage box, so that the sample management efficiency is improved.
Referring to fig. 4, an embodiment of the present invention provides a method for controlling a control system for automating and intelligentizing a microscopic pathology diagnosis process, comprising the steps of:
s1, placing a sample to be diagnosed on an objective table of a microscope 8;
s2, automatically identifying the coding information of the sample and the position of the sample on a slide of the microscope 8; the method comprises the steps of automatically identifying coding information of a sample, and preparing for subsequent data management; and automatically identifying the position of the sample area, and preparing for subsequent visual intelligent movement.
S3, driving the sample to move under the microscope 8, and automatically focusing the sample image of the visible region in real time; in this embodiment, the sample may be moved by a plurality of intelligent modes such as touch screen movement and mouse dragging, and the image of the region to be seen is automatically focused in real time.
S4, transmitting a sample image under the microscope 8 to a display screen for real-time display, and editing and analyzing the sample image; in this embodiment, the doctor can further observe and analyze the image through editing functions such as magnification, measurement, annotation, and the like.
S5, sharing diagnosis results and experiences of different doctors according to pathological diagnosis requirements; for example: remote consultation, communication sharing and the like can be realized according to pathological diagnosis needs.
S6, consulting reference data and pathological image data required by doctor diagnosis, and performing contrast diagnosis and auxiliary diagnosis;
s7, automatically generating a pathology report according to a pathological diagnosis conclusion of a doctor;
s8, automatically establishing a database for the sample after diagnosis by the doctor. Thus, the code information and the storage position of the appointed sample can be conveniently found.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The examples described above represent only a few embodiments of the present invention and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (11)
1. An automated and intelligent control system for a microscopic pathology diagnosis process, comprising:
the sample identification system is used for identifying the coding information of the sample, and is also used for identifying the position of the sample on a glass slide of a microscope and constructing a focusing curved surface of the sample;
the sample intelligent movement and automatic focusing system is used for driving the sample to move under the microscope and is also used for automatically focusing the sample under the microscope;
the image real-time display and image editing system is used for displaying sample images observed by a microscope in real time and editing and analyzing the sample images;
the shared diagnosis system is used for sharing the diagnosis results and experiences of different doctors;
the pathognomonic data consulting and comparing diagnosis system is used for providing reference data and pathological image data required by doctor diagnosis and can automatically assist diagnosis;
the pathology report writing system is used for automatically generating a pathology report according to the pathological diagnosis conclusion of a doctor;
and the sample storage management system is used for automatically establishing a database for the samples after diagnosis by the doctor.
2. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 1, wherein the sample identification system comprises:
the code identification module is used for reading and analyzing the code information on the sample;
the sample area identification module is used for positioning and identifying the position of each sample on the slide and calculating the position coordinates of the samples;
and the focusing curved surface construction module is used for automatically arranging a corresponding number of focusing points in the area in the identification edge of the sample, automatically focusing each focusing point and constructing the focusing curved surface of the sample through a software algorithm.
3. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 2, wherein the coded information is coded as an identification code or two-dimensional code, and the coded information includes a personal identification number, a medical record number, a sample type, and a department of care of the patient.
4. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 1, wherein the sample intelligent movement and autofocus system comprises:
the sample intelligent moving module comprises an X-axis motor and a Y-axis motor, wherein the X-axis motor and the Y-axis motor are respectively connected with an X-direction moving platform and a Y-direction moving platform of the microscope, the X-direction moving platform and the Y-direction moving platform are vertically stacked to form an objective table, and a slide is placed on the upper surface of the objective table, wherein the X-axis motor and the Y-axis motor are respectively used for driving the X-direction moving platform and the Y-direction moving platform to move so that a sample moves according to a preset moving path;
the image automatic focusing module comprises a Z-axis motor, and the Z-axis motor can drive an objective lens of the microscope to move up and down to automatically focus the sample.
5. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 4, wherein the Z-axis motor is disposed on a stand of a microscope, the Z-axis motor is connected to a longitudinal connecting arm, one end of the longitudinal connecting arm is connected to a transverse connecting arm, the objective lens is disposed on the transverse connecting arm at an end thereof remote from the longitudinal connecting arm, and wherein the sample recognition system is disposed on the transverse connecting arm.
6. The automated and intelligent control system for a microscopic pathology diagnosis process according to claim 5, wherein a base is provided at the bottom of the Y-direction moving platform, and the upright is fixed at one side of the base.
7. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 4, 5 or 6, wherein the image real-time display and image editing system comprises:
the image real-time display module is connected with the objective lens and is used for transmitting a sample image observed by a microscope to a display screen in real time;
and the image editing module is used for editing the sample image on the display screen.
8. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 1, wherein the pathology diagnostic profile review contrast diagnostic system comprises:
a pathology diagnosis data module for integrating reference data of pathology diagnosis;
a pathology image database module for integrating and managing pathology image data;
and the automatic auxiliary diagnosis module is used for automatically performing auxiliary diagnosis on the sample image according to the pathological image data.
9. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 8, wherein the automated auxiliary diagnostic module comprises:
the primary comparison and data retrieval unit is used for carrying out primary comparison of morphological structures on the sample image and the pathological images in the pathological image database module, and retrieving all pathological images with the similarity of more than 80%;
the high-precision comparison unit is used for sequentially rotating one of the case images by n degrees along the center point of the case image to obtain the similarity between the case images with different angles and the sample image, and selecting the highest value of the similarity as a final similarity value;
and the judging and sorting unit is used for sequentially sorting the final similarity values of all the pathological images with the similarity exceeding 80 percent according to the numerical value.
And the linking unit is used for selecting the first to m pathological images according to the descending order of the final similarity values and automatically linking the first to m pathological images with the pathological diagnosis reference data used in diagnosis.
10. The automated and intelligent control system for a microscopic pathology diagnostic process according to claim 1, wherein the sample receiving management system comprises:
the sample storage database module is used for automatically recording the coding information of the samples diagnosed by the doctor according to the sequence number to form sample codes, and the sample codes correspond to the material storage positions of the samples one by one;
the code printing module is used for driving the printer to print corresponding serial number codes on the sample storage boxes, and each sample storage box is provided with a mark consistent with the sample code.
11. A method of controlling a control system for automating and intellectualizing a microscopic pathology diagnosis procedure according to any one of claims 1-10, comprising the steps of:
s1, placing a sample to be diagnosed on an objective table of a microscope;
s2, automatically identifying the coding information of the sample and the position of the sample on a glass slide of a microscope;
s3, driving the sample to move under a microscope, and automatically focusing the sample image of the visible region in real time;
s4, transmitting a sample image under a microscope to a display screen for real-time display, and editing and analyzing the sample image;
s5, sharing diagnosis results and experiences of different doctors according to pathological diagnosis requirements;
s6, consulting reference data and pathological image data required by doctor diagnosis, and performing contrast diagnosis and auxiliary diagnosis;
s7, automatically generating a pathology report according to a pathological diagnosis conclusion of a doctor;
s8, automatically establishing a database for the sample after diagnosis by the doctor.
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