CN117309334A - Cornea shaping mirror performance test method with Tesla valve-shaped round hole unit - Google Patents
Cornea shaping mirror performance test method with Tesla valve-shaped round hole unit Download PDFInfo
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- CN117309334A CN117309334A CN202311425026.6A CN202311425026A CN117309334A CN 117309334 A CN117309334 A CN 117309334A CN 202311425026 A CN202311425026 A CN 202311425026A CN 117309334 A CN117309334 A CN 117309334A
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- 210000004087 cornea Anatomy 0.000 title claims abstract description 324
- 238000007493 shaping process Methods 0.000 title claims abstract description 179
- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000011056 performance test Methods 0.000 title abstract description 7
- 238000012360 testing method Methods 0.000 claims abstract description 48
- 238000004458 analytical method Methods 0.000 claims abstract description 32
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- 210000002919 epithelial cell Anatomy 0.000 claims description 84
- 238000004364 calculation method Methods 0.000 claims description 20
- 238000011084 recovery Methods 0.000 claims description 19
- 210000000744 eyelid Anatomy 0.000 claims description 17
- 210000005252 bulbus oculi Anatomy 0.000 claims description 15
- 238000012876 topography Methods 0.000 claims description 14
- 230000002093 peripheral effect Effects 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 238000005070 sampling Methods 0.000 claims description 9
- 210000002159 anterior chamber Anatomy 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 230000002706 hydrostatic effect Effects 0.000 claims description 6
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- 208000001491 myopia Diseases 0.000 abstract description 8
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- 230000002265 prevention Effects 0.000 abstract description 3
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- 238000010586 diagram Methods 0.000 description 6
- 238000010008 shearing Methods 0.000 description 6
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- 238000010992 reflux Methods 0.000 description 2
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- 238000005452 bending Methods 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M11/00—Testing of optical apparatus; Testing structures by optical methods not otherwise provided for
- G01M11/08—Testing mechanical properties
Abstract
The invention relates to the technical field of cornea shaping mirror tension analysis, and provides a cornea shaping mirror performance test method with a Tesla valve-shaped round hole unit, which comprises the following steps: detecting target areas of all cornea topographic maps through a neural network; constructing a gain tension signal analysis model, and analyzing gain tension signals of 4 cornea test areas; determining parameters of round holes formed by a photoetching machine in a base arc zone of a cornea shaping lens reverse arc zone or a near reverse arc zone, wherein a round hole unit formed by the photoetching machine is in a Tesla valve shape; and the COMSOL software is used for simulating and testing the working performance of the cornea shaping lens and the parameters of the cornea before and after wearing. The invention solves the problem of the prior art that the optimal structure of the reverse arc zone in the cornea shaping lens is reconstructed, and obtains shorter shaping time, longer stable vision, longer defocusing state and better myopia prevention and control effect.
Description
Technical Field
The invention relates to the technical field of cornea shaping mirror tension analysis, in particular to a cornea shaping mirror performance test method with a Tesla valve-shaped round hole unit.
Background
Cornea shaping is a technology which can actively, stepwise, gradually and scientifically change the overall state of the cornea through a contact lens with special inverse geometric design so as to quickly improve the vision of the naked eyes and control the development of teenagers' myopia. The modern cornea shaping lens adopts the design principle of reverse geometry, the shape of the inner surface of the cornea shaping lens is designed into a structure opposite to the geometry of the front surface of the cornea, a plurality of gaps are manufactured between the lens and the cornea, and the mechanical effect of tears is utilized to achieve the effect of correcting. The cornea shaping lens is a hard contact lens, a layer of tear film which is unevenly distributed is clamped between the inner surface of the lens and the outer surface of the cornea after the lens is worn, and when eyes are closed and blinks, the eyelid acts to enable the center of the lens to apply a certain pressure to the cornea below, and an upward pulling force is generated at the position of a reverse arc. The shear force effect of tears pulls the epithelial cells in the central region of the cornea toward the peripheral portion; both effects result in flattening of the curvature of the central region of the cornea, thinning of the central epithelial layer, thickening of the central peripheral portion, and movement of the object imaging point in a direction toward the retina. After wearing for a period of time, the shape of the front surface of the cornea is consistent with that of the rear surface of the cornea shaping lens, and when the rigid ventilation contact lens for cornea shaping is removed, the cornea still keeps the shape of the rear surface of the cornea shaping lens, so that the myopia degree is reduced or even eliminated.
At present, the cornea shaping lens is the first choice tool and device for preventing and controlling myopia worldwide, and after the lens is taken down in the daytime, clear naked eyes can be maintained for about 8 hours. However, when the cornea shaping glasses are worn by children, the frequency of once a day causes the experience of the children to be quite uncomfortable, and the wearing time is long for the whole night.
In the prior art, as disclosed in the prior application publication No. CN112433390a, a cornea shaping lens has an inner surface configured to change the shape of the anterior surface of the cornea, and an outer surface, wherein the inner surface is continuously formed with a base arc zone, a reversal zone and a fitting zone from the center to the outside, the base arc zone has a central zone and a peripheral zone, the radius of curvature of the central zone is smaller than that of the peripheral zone, and the diameter of the base arc zone is 5mm to 6mm.
As another example, in the prior patent application publication CN109564357a, a cornea shaping mirror is disclosed, in which a central portion of the base region is disposed; an annular portion called an inversion region disposed around the base region; an annular portion called a positioning region disposed around the inversion region; and an annular portion called a peripheral region disposed around the positioning region.
The above patent uses a method of increasing or changing the arc area in the cornea shaping lens to enhance the working effect of the cornea shaping lens, and the structure does not significantly improve the shaping effect of the cornea shaping lens.
Disclosure of Invention
The invention aims to solve the technical problem that the myopia prevention and control effect of a cornea shaping lens is insufficient in the prior art, N rows of defocusing points which are arranged in a Tesla valve shape are added between a base arc and a reverse arc or in a reverse arc area of the cornea shaping lens, so that the shearing force generated under the influence of eyelid pressure and squeezing film force causes epithelial cells to move from the center to the periphery in the Tesla valve shape more rapidly under the influence of the shearing force. Under the influence of the defocusing points arranged in a Tesla valve shape, after the cornea shaping lens is removed, the tension gain of the cornea shaping lens enables the cornea epithelium to need longer recovery time, and when the epithelial cells in the reverse arc are moved, the defocusing points arranged in the Tesla valve shape are left, so that the lens has better defocusing effect, and the capability of controlling myopia is improved by 20% on the original basis.
In order to achieve the above purpose, the invention provides a method for testing the performance of a cornea shaping lens with a Tesla valve-shaped round hole unit, which comprises the following specific steps:
A1: collecting eyeball information of myopic patients with different diopter levels, and fluorescent staining patterns and OCT information of test sheets of the myopic patients to form various cornea topographic maps;
a2: performing target area detection on each grade of cornea topographic map through a neural network, and dividing the cornea topographic map into 4 cornea test areas;
a3: constructing a gain tension signal analysis model, and analyzing gain tension signals of 4 cornea test areas;
a4: according to A3, determining parameters of round holes formed by the photoetching machine in a base arc zone of a cornea shaping lens reverse arc zone or a near reverse arc zone, wherein the round hole unit is in a Tesla valve shape;
a5: the performance of the cornea shaping lens and parameters of the cornea before and after wearing the cornea shaping lens by a myopic patient are simulated and tested by using COSMOL software.
Specifically, the myopic patient eyeball information of different diopter levels comprises: anterior and posterior surface shape of the cornea, cornea diameter, cornea thickness, cornea curvature, cornea central zone thickness, degree of corneal relief, tear layer thickness, and ocular axis length.
In particular, diopter D of said myope 0 The value range is [ -1, -5]The classification rules of myopes of different diopter grades are as follows:
When myopic patient diopter D 0 E [ -1, -2) is noted as a primary diopter myopic patient;
when myopic patient diopter D 0 E [ -2, -3) is noted as a second diopter myopic patient;
when myopic patient diopter D 0 E [ -3, -4) is noted as a tertiary diopter myopic patient;
when myopic patient diopter D 0 ∈[-4,-5]Is recorded as a four-diopter myopic patient.
Specifically, the neural network includes: an input layer, 4 convolutional layers, 4 sample layers, a full connection layer, and an output layer, wherein each convolutional layer contains P convolutional kernels of 10 x 10 size.
Specifically, the detection and division of the target area includes the following specific steps:
s41: converting cornea topography of each grade of myopic patients with 4 different diopter grades into gradient images to be input into an input layer in the neural network, wherein the intersection point of two diagonal lines of each gradient image is taken as a coordinate origin to form a two-dimensional plane coordinate system of the gradient images;
s42: through 4 convolution layers O 1 ,O 2 ,O 3 ,O 4 Target area division is carried out on cornea topographic maps of all levels of myopes with 4 different diopter levels respectively, wherein the threshold processing of gradient images in the convolution layer comprises the following steps:
at convolution layer O i The middle threshold processing formula is g i,n (x n ,y n )∈[g i-1 ,g i ],i∈{1,2...4}；
Wherein g i,n (x n ,y n ) Is the nth coordinate (x) on the ith target area edge line n ,y n ) Gradient values of pixels of (a);
g i the maximum value in gradient values of all pixel points of the ith target area;
g i-1 the maximum value in gradient values of all pixel points of the i-1 target area;
x n the abscissa of the nth pixel point in the two-dimensional plane coordinate system of the gradient image in the S41;
y n the ordinate of the nth pixel point in the two-dimensional plane coordinate system of the gradient image in the S41;
wherein [ g ] i-1 ,g i ]The gradient value threshold interval of the pixel point in the ith target area is set;
the dividing standard of the target area is as follows: when the gradient value of a pixel point in the gradient image belongs to the threshold value interval, the pixel point belongs to the ith target area;
s43: through 4 sampling layers M 1 ,M 2 ,M 3 ,M 4 Sampling and extracting 4 target areas in each grade of cornea topographic map output by the 4 convolution layers respectively;
s44: marking 4 target areas extracted by the sampling layer through the full-connection layer, wherein the 1 st target area is marked as a red area, the 2 nd target area is marked as a yellow area, the 3 rd target area is marked as a green area and the 4 th target area is marked as a blue area; simultaneously compressing 4 target areas into one-dimensional vectors, and finally outputting the vectors through an output layer to finish training a neural network, wherein a full-connection layer is activated by adopting a softmax function;
S45: according to the S44, 4 target areas are corresponding to cornea topographic maps of each grade of myopes of 4 different diopter grades, and 4 cornea test areas are divided.
Specifically, the dividing of the cornea test area includes:
the corneal height interval in the corneal topography corresponding to the ith target area is:
e′ i ∈[e i-1 ,e i )，i∈{1,2...4}；
wherein e' i A corneal elevation value in the corneal topography corresponding to the ith target area;
e i the upper limit value of the cornea height section in the cornea topographic map corresponding to the ith target area;
e i-1 the lower limit value of the cornea height section in the cornea topographic map corresponding to the ith target area.
Specifically, the cornea shaping mirror comprises: on the inner surface of the cornea shaping lens, a base arc area, a reverse arc area, a positioning arc area and a peripheral arc area are sequentially arranged from a central round point to an outer circular ring.
Specifically, circular holes are formed in the surface of the base arc region of the reverse arc region or the near-reverse arc region and are arranged in a Tesla valve shape, two large-aperture circular holes and two small-aperture circular holes are a circular hole unit, and the circular holes are in a Tesla valve shape, so that the flow velocity of tears and epithelial cells can be regulated.
Specifically, the construction of the gain tension signal analysis model comprises the following specific steps:
S71: constructing a gain tension signal analysis unit, comprising: the cross section of one round hole in the reverse arc zone of the cornea shaping lens, and the volume between the cornea shaping lens and the cornea is v 1 A unit corneal epithelial cell I and a unit corneal epithelial cell II;
wherein the cross section of the round hole is provided with a radius r 1 The sphere center is point O 1 A noon tangent plane of the ball I, the upper and lower tangent points are point A respectively 1 And point A 2 The method comprises the steps of carrying out a first treatment on the surface of the The contact surface of the cornea unit is a radius r 2 The sphere center is point O 2 One noon tangent plane of the ball two, the upper and lower tangent points are point B respectively 1 And point B 2 ；
Wherein, line A 1 A 2 For point A 1 And point A 2 Line B of (C) 1 B 2 For point B 1 And point B 2 Line O of (C) 1 O 2 Is point O 1 And point O 2 Is connected with the connecting line of the (a);
wherein point O 1 In straight line A 1 A 2 Point O on the left side of (2) 2 In straight line B 1 B 2 Right side of (2);
wherein, straight line O 1 O 2 Length D of (2) 2 Point A 1 And point A 2 With respect to straight line O 1 O 2 Symmetry, point B 1 And point B 2 With respect to straight line O 1 O 2 Symmetrical;
s72: constructing a two-dimensional plane coordinate system of a gain tension signal analysis unit, wherein the center of the cross section of a round hole in the cornea shaping lens is the origin of the two-dimensional plane coordinate system, and the straight line O 1 O 2 Is the x-axis of a two-dimensional plane coordinate system, straight line A 1 A 2 Is the y-axis of a two-dimensional plane coordinate system, wherein the point O 1 To O 2 Is in the positive direction of the x-axis, point A 2 To point A 1 Is the positive direction of the y axis;
wherein the unit corneal epithelial cells form two arc functions between the cornea shaping lens and the cornea asf (x) and g (x) are related to a straight line O 1 O 2 Symmetrical, x is the abscissa of a point in a two-dimensional plane coordinate system, and y is the ordinate of a point in the two-dimensional plane coordinate system;
wherein the upper contact angle between the unit cornea epithelial cells and the inner surface of the cornea shaping lens is alpha 1 An upper contact angle alpha with the outer surface of the cornea 2 The method comprises the steps of carrying out a first treatment on the surface of the The upper filling angle of the unit cornea epithelial cells and the inner surface of the cornea shaping lens is beta 1 Upper contact angle beta with the outer surface of cornea 2 。
Specifically, the analysis of the gain tension signal of the cornea test zone comprises the following specific steps:
s81: area S of cross section of the round hole A The calculation strategy of (2) is as follows:
S A ＝2πr 1 2 ×(sinβ 1 ) 2 ；
wherein pi is the circumference ratio;
area S of the contact surface of the unit cornea with which the unit cornea epithelial cells come into contact B The calculation strategy of (2) is as follows:
S B ＝2πr 2 2 ×(sinβ 2 ) 2 ；
s82: volume v 1 The calculation strategy for the total contact area of unit corneal epithelial cell one with unit corneal epithelial cell two and unit corneal epithelial cell three is as follows:
wherein S is 2 Is the contact area of the unit corneal epithelial cell II and the unit corneal epithelial cell I;
S 3 the contact area of the unit corneal epithelial cells III and the unit corneal epithelial cells I;
is the upper tangent point B 1 Is the abscissa of (2); pi is the circumference ratio;
f (x) is the arcuate function formed by the unit corneal epithelial cells between the cornea shaping lens and the cornea;
to be in interval->Integrating the x;
f' (x) is the derivative of f (x);
s83: calculating the gain tension of the cornea shaping lens on the cornea, wherein the cornea gain tension F tm The calculation strategy of (2) is as follows:
wherein F is tm Cornea gain tension of a gain tension signal analysis unit;
F co intrinsic attractive force as a unit of corneal epithelial cell molecule;
e is the constant internal free energy of a gain tension signal analysis unit;
Δf is the shear force generated under the influence of eyelid pressure and squeeze film force;
Δp tm-co is the difference between the pressure of the anterior chamber of the eyeball to the cornea and the pressure of the eyelid to the cornea when the eyelid is naturally closed;
Δp co-co a difference in hydrostatic pressure of tear molecules between the first unit corneal epithelial cell and the second unit corneal epithelial cell;
v is the volume of the unit corneal epithelial cells; d (D) 2 Is O 1 With O 2 A linear distance therebetween;
phi is the contact coefficient, where
Specifically, compared with a common cornea shaping lens, the cornea shaping lens with round holes in the base arc area of the reverse arc area or the near reverse arc area is increased from a single reverse arc shaping working area to a double shaping working area with round holes before the reverse arc area by the existence of the shearing force delta F, so that the shaping time is greatly shortened.
According to hydrodynamic effect, the shearing force delta F generated by epithelial cell molecules under the influence of eyelid pressure and squeezing membrane force is preferentially absorbed by the round hole shaping working area to form an epithelial cell protruding point, and then the epithelial cells are shaped through the reverse arc shaping working area. The added circular hole shaping working area enables epithelial cells to move from the center to the peripheral defocusing point more quickly, reduces the time for completing one-time cornea shaping, and achieves the purposes of cornea shaping and myopia correction.
Meanwhile, in the cornea recovery process, under the action of the round hole units which are arranged in a Tesla valve shape in the shaping working area, the cornea recovery time is prolonged, the working performance of the cornea shaping lens is improved, and the wearing frequency of the shaping lens is reduced.
Specifically, the determination of parameters of the round hole punched by the photoetching machine comprises the following steps:
diameter d of round hole hole,J Is d hole,J ＝2r 1 ×sinβ 1 ×J,J∈{1,2}；
Depth h of round hole hole Is h hole ＝r 1 ×(1-cosβ 1 )；
Number of circular holes N in each cornea test zone hole Is that
Wherein G is f Is the oxygen-containing concentration in the anterior chamber of the eyeball; μ is the corneal height difference coefficient;
e′ i a cornea height value in the cornea topographic map corresponding to the ith target area;
e 4 the upper limit value of the cornea height interval in the cornea topographic map corresponding to the 4 th target area;
Epsilon is the oxygen permeability coefficient of the material used by the cornea shaping lens;
G o is the oxygen concentration in the air around the eyelid;
h is the thickness of the cornea shaping lens after the reverse arc is removed;
wherein, when j=1, d hole,1 The diameter of the small-aperture round hole;
when j=2, d hole,2 Is the diameter of a large-aperture round hole.
Wherein, the micro lens is arranged on the inner concave surface of the cornea shaping lens, and is scanned and punched for a plurality of times by a UC-100-vision lathe or by deep ultraviolet laser with the wavelength of less than 157nm, the precision of each scanning is 100nm, and if the out-of-focus micro lens with the height of 2 microns is manufactured, 20 scans are required to be scannedDrawing unit。
Specifically, the difference Δp between the hydrostatic pressure of tear molecules in the first unit corneal epithelial cell and the second unit corneal epithelial cell co-co The calculation strategy of (2) is as follows:
wherein mu 0 Is the viscosity coefficient of tear molecules; pi is the circumference ratio;
v is the viscosity coefficient of the inner surface of the cornea shaping lens;
d is the diameter of the lens of the cornea shaping lens;
h is the maximum thickness of the tear layer; the thickness of the alpha tear layer is the average.
Specifically, the simulation test of the working performance of the cornea shaping lens comprises the following steps:
the calculation strategy for the gain Δt of the cornea recovery time is as follows:
wherein K is the tension elastic coefficient of the material used by the cornea shaping lens;
C 1 Radius of curvature of cornea for myopic patient, C 2 Radius of curvature for a cornea shaping mirror;
a is the surface area of the concave surface of the cornea shaping mirror.
Specifically, the working principles of COSMOL software include: complex problems of multiple physical field interactions are simulated and analyzed through model building, grid generation, multiple physical field modeling, numerical solution and visualization processing steps.
In addition, a cornea shaping lens performance test system with a Tesla valve-shaped round hole unit is provided, and the cornea shaping lens performance test system comprises the following modules: the system comprises an eyeball information acquisition module, a cornea topography characteristic classification module, a gain tension signal analysis module, a round hole parameter calculation module and a cornea shaping lens working performance test module;
the eyeball information acquisition module is used for acquiring eyeball information of myopes with different diopter levels, fluorescent staining patterns and OCT information of test sheets of the myopes, and forming various cornea topographic maps;
the cornea topography feature classification module detects target areas of cornea topography of each level through a neural network, and divides the cornea topography of each level into 4 cornea test areas;
the gain tension signal analysis module is used for constructing a gain tension signal analysis model and analyzing gain tension signals of 4 cornea test areas;
The round hole parameter calculation module is used for determining parameters of round holes formed by the photoetching machine in a base arc area of a cornea shaping lens reverse arc area or a near reverse arc area, and the formed round hole unit is in a Tesla valve shape;
the cornea shaping lens working performance testing module uses COSMOL software to simulate and test the working performance of the cornea shaping lens and parameters of the cornea before and after the cornea shaping lens is worn by a myopic patient.
Compared with the prior art, the invention has the following technical effects:
1. according to the invention, N rows of defocusing points which are arranged in a Tesla valve shape are added in the base arc region of the cornea shaping lens reverse arc region or near reverse arc region, so that shearing force generated under the influence of eyelid pressure and squeezing film force can enable epithelial cells to move from the center to the defocusing points which are arranged in a Tesla valve shape more quickly under the influence of the shearing force, and the daily wearing cornea shaping lens can be developed, only 2 hours are required, and the safety is greatly improved.
2. Compared with the common cornea shaping lens, the cornea shaping lens with round holes in the base arc area of the reverse arc area or the near reverse arc area has the advantages that the shaping process is increased from a single reverse arc shaping working area to a double shaping working area of the round hole before reverse arc area, and the shaping time is greatly shortened.
3. According to the invention, parameters of round holes are determined by analyzing tension signals of round holes distributed in Tesla valve-shaped arrangement according to the surface of a base arc region of a reverse arc region or a near reverse arc region, and the problem that the tension distribution of each arc region cannot be individually adjusted according to the self condition of a myopic patient is solved.
4. According to the cornea shaping lens, the concave starting points extending towards the outer surface direction are arranged in the reverse arc area, when more than two rows of concave starting points are arranged, each row of concave starting points form an arrangement mode of a Tesla valve-shaped structure, the structure can increase the surface tension of cornea epithelial cells when being worn on a cornea, and the shaping effect of the cornea shaping lens is improved from the angle of increasing the tension. After the shaping lens is taken off, the cornea of a myopic patient is not easy to recover, so that the recovery period is prolonged, and the wearing frequency of the shaping lens is reduced.
5. According to tension signal analysis of round holes uniformly distributed on the surface of a base arc region of a reverse arc region or a near reverse arc region and arranged in a tesla valve shape, the working performance of the cornea shaping lens is simulated and tested: after a myopic patient wears the cornea shaping lens for 10 hours, the recovery time of cornea shaping is increased from 8 hours to 12 hours to 15 hours to 36 hours. The cornea shaping and restoring period of a myopic patient is greatly prolonged, the wearing times and time of the myopic patient are reduced, the uncomfortable feeling caused by wearing the cornea shaping lens for a long time for multiple times is relieved, the patient experience is promoted, and a better myopia prevention and control effect is obtained.
6. The round holes punched in the inverted arc area of the cornea shaping lens by the photoetching machine are arranged in a Tesla valve shape, and the round hole structure arranged in the Tesla valve shape has stronger extrusion resistance and bending resistance because the round holes are mutually supported by a plurality of combined units without local collapse instability when receiving eyelid pressure. Compared with other geometric structures such as circles or squares, the round holes are arranged in a tesla valve shape, and have stronger stability.
7. According to the invention, round holes punched in the reversing arc area of the cornea shaping lens through the photoetching machine are arranged in a Tesla valve shape, epithelial cells are shaped into a circular island shape by the round holes arranged in the Tesla valve shape, after the cornea shaping lens is taken out, the circular island blocks tear from returning to the center from the reversing arc, so that the reflux speed is slower than that of the shaping and restoring process of the existing cornea shaping lens, the restoration of the epithelial cells is slower, and meanwhile, the out-of-focus point also plays a great help role in the focus tracking action of peripheral retina.
Drawings
Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the following drawings in which:
FIG. 1 is a flow chart of a method for testing performance of a cornea shaping lens with Tesla valve shaped round hole unit according to an embodiment of the present invention;
fig. 2 is a schematic diagram of a neural network according to an embodiment of the present invention;
FIG. 3 is a front view showing a cornea shaping lens structure according to an embodiment one to an embodiment six of the present invention;
FIG. 4 is a view showing 4 cornea test areas divided by one to six embodiments of the present invention;
FIG. 5 is a schematic diagram of a gain tension signal analysis unit according to the first to sixth embodiments of the present invention;
FIG. 6 is a microscopic schematic diagram of a gain tension signal analysis unit according to the first to sixth embodiments of the present invention;
FIG. 7 is a diagram showing a shaping process of a cornea shaping lens according to the first to sixth embodiments of the present invention;
FIG. 8 is a three-dimensional schematic view of a single set of round hole units arranged in a Tesla valve shape on a cornea shaping lens according to an embodiment I to an embodiment II of the present invention;
FIG. 9 is a three-dimensional schematic diagram of a plurality of sets of round hole units arranged in a Tesla valve shape on a cornea shaping lens according to an embodiment one to an embodiment six of the present invention;
FIG. 10 is a schematic diagram showing the shaping process of epithelial cells passing through a single set of round holes arranged in a Tesla valve shape according to the first to sixth embodiments of the present invention.
Reference numerals: 101. a base arc region; 102. reversing the arc area; 103. positioning an arc area; 104. a peripheral arc region; 105. a round hole; 106. red areas; 107. yellow areas; 108. a green region; 109. a blue region; 201. a central region of the cornea; 202. the cross section of the round hole; 203. a corneal unit contact surface; 204. a unit corneal epithelial cell I; 205. a unit corneal epithelial cell II; 206. a unit corneal epithelial cell three; 207. gain tension signal analysis unit; 208. shear force; 209. a cornea shaping mirror; 301. cornea; 302. anterior chamber fluid; 303. a tear layer; 304. a large aperture round hole; 305. a small-aperture round hole; 306. a round hole unit.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the present invention is described below by means of specific embodiments shown in the accompanying drawings. It should be understood that the description is only illustrative and is not intended to limit the scope of the invention. In addition, in the following description, descriptions of well-known structures and techniques are omitted so as not to unnecessarily obscure the present invention.
Embodiment one:
as shown in fig. 1 and fig. 2 to fig. 10, the method for testing the performance of the cornea shaping lens with the tesla valve-shaped round hole unit according to the embodiment of the invention comprises the following specific steps:
Taking a rabbit wearing the cornea shaping lens 209 as an example, after testing and wearing the cornea shaping lens 209, the gain of the cornea 301 recovery time is calculated, as shown in fig. 1, and the specific steps are as follows:
a1: collecting eyeball information of myopic patients with different diopter levels, and fluorescent staining patterns and OCT information of test sheets of the myopic patients to form various cornea topographic maps;
specifically, the myopic patient eyeball information of different diopter levels comprises: the anterior-posterior surface shape of cornea 301, cornea diameter, cornea thickness, cornea curvature, cornea central zone 201 thickness, the degree of concavity and convexity of cornea 301, tear layer 303 thickness and eye axis length.
In particular, diopter D of said myope 0 The value range is [ -1, -5]The classification rules of myopes of different diopter grades are as follows:
when myopic patient diopter D 0 E [ -1, -2) is noted as a primary diopter myopic patient;
when myopic patient diopter D 0 E [ -2, -3) is noted as a second diopter myopic patient;
when myopic patient diopter D 0 E [ -3, -4) is noted as a tertiary diopter myopic patient;
when approachingDiopter D of vision patient 0 ∈[-4,-5]Is recorded as a four-diopter myopic patient.
The diopter D of the eyeball of the rabbit 0 E [ -3, -4), belonging to a three-level diopter myopic patient.
A2: performing target area detection on each grade of cornea topographic map through a neural network, and dividing the cornea topographic map into 4 cornea test areas;
specifically, as shown in fig. 2, the neural network includes: an input layer, 4 convolutional layers, 4 sample layers, a full connection layer, and an output layer, wherein each convolutional layer contains P convolutional kernels of 10 x 10 size.
Specifically, the detection and division of the target area includes the following specific steps:
s41: converting cornea topography of each grade of myopic patients with 4 different diopter grades into gradient images to be input into an input layer in the neural network, wherein the intersection point of two diagonal lines of each gradient image is taken as a coordinate origin to form a two-dimensional plane coordinate system of the gradient images;
s42: through 4 convolution layers O 1 ,O 2 ,O 3 ,O 4 Target area division is carried out on cornea topographic maps of all levels of myopes with 4 different diopter levels respectively, wherein the threshold processing of gradient images in the convolution layer comprises the following steps:
at convolution layer O i The middle threshold processing formula is g i,n (x n ,y n )∈[g i-1 ,g i ],i∈{1,2...4}；
Wherein g i,n (x n ,y n ) Is the nth coordinate (x) on the ith target area edge line n ,y n ) Gradient values of pixels of (a);
g i the maximum value in gradient values of all pixel points of the ith target area;
g i-1 The maximum value in gradient values of all pixel points of the i-1 target area;
x n the abscissa of the nth pixel point in the two-dimensional plane coordinate system of the gradient image in the S41;
y n the ordinate of the nth pixel point in the two-dimensional plane coordinate system of the gradient image in the S41;
wherein [ g ] i-1 ,g i ]The gradient value threshold interval of the pixel point in the ith target area is set;
the dividing standard of the target area is as follows: when the gradient value of a pixel point in the gradient image belongs to the threshold value interval, the pixel point belongs to the ith target area;
s43: through 4 sampling layers M 1 ,M 2 ,M 3 ,M 4 Sampling and extracting 4 target areas in each grade of cornea topographic map output by the 4 convolution layers respectively;
s44: as shown in fig. 4, the 4 kinds of target areas extracted by the sampling layer are marked by the full connection layer, wherein the 1 st kind of target area is marked as a red area 106, the 2 nd kind of target area is marked as a yellow area 107, the 3 rd kind of target area is marked as a green area 108 and the 4 th kind of target area is marked as a blue area 109; simultaneously compressing 4 target areas into one-dimensional vectors, and finally outputting the vectors through an output layer to finish training a neural network, wherein a full-connection layer is activated by adopting a softmax function;
S45: according to the S44, 4 target areas are corresponding to cornea topographic maps of each grade of myopes of 4 different diopter grades, and 4 cornea test areas are divided.
Specifically, the dividing of the cornea test area includes:
the corneal height interval in the corneal topography corresponding to the ith target area is:
e′ i ∈[e i-1 ,e i )，i∈{1,2...4}；
wherein e' i A corneal elevation value in the corneal topography corresponding to the ith target area;
e i the upper limit value of the cornea height section in the cornea topographic map corresponding to the ith target area;
e i-1 the lower limit value of the cornea height section in the cornea topographic map corresponding to the ith target area.
In the corneal topography of the rabbit, the upper limit value of the cornea height of each target area is as follows:
e 0 ＝7.5mm,e 1 ＝8.0mm,e 2 ＝8.5mm,e 3 ＝9.0mm,e 4 ＝9.5mm；
a3: constructing a gain tension signal analysis model, and analyzing gain tension signals of 4 cornea test areas;
specifically, as shown in fig. 5, the construction of the gain tension signal analysis model includes the following specific steps:
s71: constructing a gain tension signal analysis unit 207 comprising: the cornea shaping mirror 209 reverses the cross section 202 of one circular aperture in the arc zone 102, the volume between the cornea shaping mirror 209 and the cornea 301 being v 1 A first unit corneal epithelial cell 204 and a second unit corneal epithelial cell 205;
Wherein the cross section 202 of the round hole is provided with a radius r 1 The sphere center is point O 1 A noon tangent plane of the ball I, the upper and lower tangent points are point A respectively 1 And point A 2 The method comprises the steps of carrying out a first treatment on the surface of the The unit contact surface 203 of cornea is of radius r 2 The sphere center is point O 2 One noon tangent plane of the ball two, the upper and lower tangent points are point B respectively 1 And point B 2 ；
Wherein, line A 1 A 2 For point A 1 And point A 2 Line B of (C) 1 B 2 For point B 1 And point B 2 Line O of (C) 1 O 2 Is point O 1 And point O 2 Is connected with the connecting line of the (a);
wherein point O 1 In straight line A 1 A 2 Point O on the left side of (2) 2 In straight line B 1 B 2 Right side of (2);
wherein, straight line O 1 O 2 Length D of (2) 2 Point A 1 And point A 2 With respect to straight line O 1 O 2 Symmetry, point B 1 And point B 2 With respect to straight line O 1 O 2 Symmetrical;
s72: constructing a two-dimensional gain tension signal analysis unit 207A plane coordinate system, wherein the center of the cross section 202 of the round hole in the cornea shaping mirror 209 is the origin of the two-dimensional plane coordinate system, line O 1 O 2 Is the x-axis of a two-dimensional plane coordinate system, straight line A 1 A 2 Is the y-axis of a two-dimensional plane coordinate system, wherein the point O 1 To O 2 Is in the positive direction of the x-axis, point A 2 To point A 1 Is the positive direction of the y axis;
wherein the two arc functions formed by the unit corneal epithelial cells between the cornea shaping lens 209 and the cornea 301 aref (x) and g (x) are related to a straight line O 1 O 2 Symmetrical, x is the abscissa of a point in a two-dimensional plane coordinate system, and y is the ordinate of a point in the two-dimensional plane coordinate system;
Wherein the upper contact angle between the unit corneal epithelial cells and the inner surface of the cornea shaping lens 209 is alpha 1 An upper contact angle alpha with the outer surface of the cornea 2 The method comprises the steps of carrying out a first treatment on the surface of the The upper filling angle of the unit cornea epithelial cells and the inner surface of the cornea shaping lens 209 is beta 1 Upper contact angle beta with the outer surface of cornea 2 。
Specifically, as shown in fig. 6 and 7, the analysis of the gain tension signal of the cornea test zone includes the following specific steps:
s81: area S of the cross section 202 of the circular hole A The calculation strategy of (2) is as follows:
S A ＝2πr 1 2 ×(sinβ 1 ) 2 ；
wherein pi is the circumference ratio;
area S of the unit contact surface 203 of the cornea with which the unit corneal epithelial cells come into contact B The calculation strategy of (2) is as follows:
S B ＝2πr 2 2 ×(sinβ 2 ) 2 ；
s82: volume v 1 The calculation strategy for the total contact area of unit corneal epithelial cell one 204 with unit corneal epithelial cell two 205 and unit corneal epithelial cell three 206 is as follows:
wherein S is 2 Contact area of unit corneal epithelial cell two 205 and unit corneal epithelial cell one 204;
S 3 contact area of unit corneal epithelial cell three 206 and unit corneal epithelial cell one 204;
is the upper tangent point B 1 Is the abscissa of (2); pi is the circumference ratio;
f (x) is the arcuate function that the unit corneal epithelial cells form between the cornea shaping lens 209 and the cornea 301;
To be in interval->Integrating the x;
f' (x) is the derivative of f (x);
s83: the gain tension of the cornea shaping mirror 209 on the cornea 301 is calculated, wherein the cornea gain tension F tm The calculation strategy of (2) is as follows:
wherein F is tm A gain tension of the cornea for a gain tension signal analysis unit 207;
F co intrinsic attractive force as a unit of corneal epithelial cell molecule;
e is the constant internal free energy of a gain tension signal analysis unit 207;
Δf is the shear force 208 generated under the influence of eyelid pressure and squeeze film force;
Δp tm-co is the difference between the pressure of the anterior chamber of the eyeball against the cornea 301 and the pressure of the eyelid against the cornea 301 when the eyelid is naturally closed;
Δp co-co a difference in hydrostatic pressure of tear molecules between unit corneal epithelial cell one 204 and unit corneal epithelial cell two 205;
v is the volume of the unit corneal epithelial cells; d (D) 2 Is O 1 With O 2 A linear distance therebetween;
phi is the contact coefficient, where
Specifically, the tear molecule hydrostatic pressure difference Δp between the first unit corneal epithelial cell 204 and the second unit corneal epithelial cell 205 co-co The calculation strategy of (2) is as follows:
wherein mu 0 Is the viscosity coefficient of tear molecules; pi is the circumference ratio;
v is the viscosity coefficient of the inner surface of the lens of the cornea shaping lens 209;
d is the lens diameter of the cornea shaping lens 209;
h is the maximum thickness of tear layer 303; the alpha tear layer 303 has a thickness average.
The gain tension of the cornea of the rabbit is as follows: f (F) tm ＝11.3N。
A4: according to A3, determining parameters of a round hole 105 formed by a photoetching machine in a base arc area 101 of a cornea shaping lens 209 reverse arc area 102 or a near reverse arc area 102, wherein a round hole unit 306 is formed and is in a Tesla valve shape;
specifically, as shown in fig. 3, specifically, the cornea shaping mirror 209 includes: on the inner surface of the cornea shaping mirror 209, from the center dot to the outer ring, there are in this order a base arc region 101, a reverse arc region 102, a positioning arc region 103, and a peripheral arc region 104.
Specifically, as shown in fig. 8 and 9, the circular holes 105 on the surface of the base arc region 101 of the reverse arc region 102 or the near reverse arc region 102 are arranged in a tesla valve shape, and the two large-aperture circular holes 304 and the two small-aperture circular holes 305 are one circular hole unit 306, which is in a tesla valve shape, so as to regulate the flow rate of tears and epithelial cells.
Specifically, as shown in fig. 10, the round holes 105 punched in the inverted arc area 102 of the cornea shaping lens 209 are arranged in a tesla valve shape, the epithelial cells are shaped into a circular island shape by the round hole units 306 arranged in a tesla valve shape, and after the cornea shaping lens 209 is taken out, the circular island blocks tear from returning to the center from the inverted arc, so that the reflux speed is slower than that in the shaping and restoring process of the existing cornea shaping lens 209, and the restoration of the epithelial cells is slower.
Specifically, the determining parameters of the round hole 105 formed by the lithography machine includes:
diameter d of round hole 105 hole,J Is d hole,J ＝2r 1 ×sinβ 1 ×J,J∈{1,2}；
Depth h of round hole 105 h o le Is h hole ＝r 1 ×(1-cosβ 1 )；
Number N of circular holes 105 in each cornea test zone hole Is that
Wherein G is f Is the oxygen-containing concentration in anterior chamber of the eye 302; μ is the corneal height difference coefficient;
e′ i a cornea height value in the cornea topographic map corresponding to the ith target area;
e 4 the upper limit value of the cornea height interval in the cornea topographic map corresponding to the 4 th target area;
epsilon is the oxygen permeability coefficient of the material used for the cornea shaping lens 209;
G o is the oxygen concentration in the air around the eyelid;
h is the corneal shaping lens 209 reverse arc lens thickness;
wherein, when j=1, d hole,1 Is the diameter of the small-bore circular hole 305;
when j=2, d hole,2 Is the diameter of the large aperture circular hole 304.
The number of rows of the round holes 105 is 2, the diameters of the round holes 105 are 0.2mm and 0.1mm respectively, the depth of the round holes is 0.002mm, and the number of the round holes 105 of the innermost ring is 36.
A5: the performance of the cornea shaping lens 209 and parameters of the cornea 301 before and after wearing the cornea shaping lens 209 by a myopic patient were simulated and tested with COSMOL software.
Specifically, the working principles of COSMOL software include: complex problems of multiple physical field interactions are simulated and analyzed through model building, grid generation, multiple physical field modeling, numerical solution and visualization processing steps.
Specifically, the simulation test of the working performance of the cornea shaping mirror 209 includes:
the calculation strategy for the gain Δt for the cornea 301 recovery time is as follows:
wherein K is the tension elastic coefficient of the material used for the cornea shaping lens 209;
C 1 radius of curvature of cornea for myopic patient, C 2 Radius of curvature for the cornea shaping mirror 209;
a is the surface area of the concave surface of the cornea shaping mirror 209.
After the rabbit wears the cornea shaping lens 209, the gain Δt of the cornea 301 recovery time is:
ΔT＝19.54h。
embodiment two:
the specific steps of the method are the same as those of the first embodiment, and the difference is that the number of rows of the round holes 105 is 4, the diameters of the round holes 105 are respectively 0.2mm and 0.1mm, the depth of the round holes 105 is 0.002mm, and the number of the round holes 105 at the innermost ring is 36.
Embodiment III:
the specific steps of the method are the same as those of the first embodiment, and the difference is that the number of rows of the round holes 105 is 6, the diameters of the round holes 105 are 0.2mm and 0.1mm, the depth of the round holes 105 is 0.002mm, and the number of the round holes 105 at the innermost ring is 36.
Embodiment four:
the specific steps of the method are the same as those of the first embodiment, and the difference is that the number of rows of the round holes 105 is 8, the diameters of the round holes 105 are 0.2mm and 0.1mm, the depth of the round holes 105 is 0.002mm, and the number of the round holes 105 at the innermost ring is 36.
Fifth embodiment:
the specific steps of the method are the same as those of the first embodiment, and the difference is that the number of rows of the round holes 105 is 4, the diameters of the round holes 105 are respectively 0.2mm and 0.1mm, the depth of the round holes 105 is 0.0016mm, and the number of the round holes 105 at the innermost ring is 38.
Example six:
the specific steps of the method are the same as those of the first embodiment, and the difference is that the number of rows of the round holes 105 is 4, the diameters of the round holes 105 are respectively 0.2mm and 0.1mm, the depth of the round holes 105 is 0.002mm, and the number of the round holes 105 at the innermost ring is 33.
Comparative example:
the specific steps of the method for testing the performance of the cornea shaping lens with the tesla valve-shaped round hole unit in the embodiment of the invention are the same as those in the first embodiment, and the difference is that the reverse arc area 102 of the cornea shaping lens 209 is distributed without round holes 105.
Table 1 shows specific parameters of each example.
Table 1 specific parameters of each example
Experimental analysis was performed on the cornea-shaping lenses 209 of examples one to six, and the performances of each set of cornea-shaping lenses 209 were analyzed using the existing cornea-shaping lenses as comparative examples.
The experimental process comprises the following specific steps:
1. corneal recovery cycle experiment
Rabbits with similar ages and similar eyesight are taken as study objects, 15 samples in each group are used for wearing the cornea shaping lens 209 for the rabbits, the wearing time is 10 hours, the wearing period is one week, after the shaping lens is taken off, the recovery condition of the cornea 301 is detected every 30 minutes, and the average recovery period of each group of samples is recorded.
The experimental results of the cornea recovery period experiment are shown in table 2.
Table 2 cornea recovery period
From the above results, the cornea shaping lens 209 can significantly lengthen the recovery time of the corneal epithelial cells, and the effect of the third embodiment is most remarkable. This is because the round hole unit 306 is configured to increase the surface tension of the corneal epithelial cells, and further to increase the surface tension of the corneal epithelial cells in combination with the tesla valve-like arrangement, so that when the lens is worn, the larger surface tension can increase the tension on the epithelial cells, and after the lens 209 is removed, the cycle of epithelial cell recovery can be increased due to the larger surface tension, so that the frequency of wearing the lens can be reduced.
2. Correction cycle experiment
The cornea shaping lens 209 enhances the shaping effect on the cornea 301, reducing the correction period. After the rabbit wears the cornea shaping lens 209 for 10 hours, the recovery time of cornea shaping is increased from 8 hours to 12 hours to 15 hours to 36 hours. The cornea shaping recovery period of the rabbit is greatly prolonged, the wearing times and time of the rabbit are reduced, and the uncomfortable feeling caused by wearing the cornea shaping mirror 209 for a long time and multiple times is relieved.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (12)
1. A method for testing the performance of a cornea shaping lens with a tesla valve-shaped round hole unit, which is characterized by comprising the following specific steps:
a1: collecting eyeball information of myopic patients with different diopter levels, and fluorescent staining patterns and OCT information of test sheets of the myopic patients to form various cornea topographic maps;
A2: performing target area detection on each grade of cornea topographic map through a neural network, and dividing the cornea topographic map into 4 cornea test areas;
a3: constructing a gain tension signal analysis model, and analyzing gain tension signals of 4 cornea test areas;
a4: according to A3, determining parameters of round holes formed by the photoetching machine in a base arc zone of a cornea shaping lens reverse arc zone or a near reverse arc zone, wherein the round hole unit is in a Tesla valve shape;
a5: the performance of the cornea shaping lens and parameters of the cornea before and after wearing the cornea shaping lens by a myopic patient are simulated and tested by using COSMOL software.
2. The method for testing the performance of a cornea shaping lens with tesla valve shaped round hole unit according to claim 1, wherein the eyeball information of myopes with different diopter levels comprises: anterior and posterior surface shape of the cornea, cornea diameter, cornea thickness, cornea curvature, cornea central zone thickness, degree of corneal relief, tear layer thickness, and ocular axis length.
3. The method for testing the performance of a cornea shaping lens with tesla valve-shaped round hole unit according to claim 1, wherein the diopter D of the myopic patient 0 The value range is [ -1, -5]The classification rules of myopes of different diopter grades are as follows:
when myopic patient diopter D 0 E [ -1, -2) is noted as a primary diopter myopic patient;
when myopic patient diopter D 0 E [ -2, -3) is noted as a second diopter myopic patient;
when myopic patient diopter D 0 E [ -3, -4) is noted as a tertiary diopter myopic patient;
when myopic patient diopter D 0 ∈[-4,-5]Is recorded as a four-diopter myopic patient.
4. The method for testing the performance of a cornea shaping lens with tesla valve-shaped round hole unit according to claim 1, wherein the neural network comprises: an input layer, 4 convolutional layers, 4 sample layers, a full connection layer, and an output layer, wherein each convolutional layer contains P convolutional kernels of 10 x 10 size.
5. The method for testing the performance of the cornea shaping lens with the tesla valve-shaped round hole unit according to claim 4, wherein the detection division of the target area comprises the following specific steps:
s41: converting cornea topography of each grade of myopic patients with 4 different diopter grades into gradient images to be input into an input layer in the neural network, wherein the intersection point of two diagonal lines of each gradient image is taken as a coordinate origin to form a two-dimensional plane coordinate system of the gradient images;
S42: through 4 convolution layers O 1 ,O 2 ,O 3 ,O 4 Target area division is carried out on cornea topographic maps of each grade of myopes with 4 different diopter grades respectively, wherein the cornea topographic maps are in the convolution layerThresholding the gradient image includes:
at convolution layer O i The middle threshold processing formula is g i,n (x n ,y n )∈[g i-1 ,g i ],i∈{1,2...4}；
Wherein g i,n (x n ,y n ) Is the nth coordinate (x) on the ith target area edge line n ,y n ) Gradient values of pixels of (a);
g i the maximum value in gradient values of all pixel points of the ith target area;
g i-1 the maximum value in gradient values of all pixel points of the i-1 target area;
x n the abscissa of the nth pixel point in the two-dimensional plane coordinate system of the gradient image in the S41;
y n the ordinate of the nth pixel point in the two-dimensional plane coordinate system of the gradient image in the S41;
wherein [ g ] i-1 ,g i ]The gradient value threshold interval of the pixel point in the ith target area is set;
the dividing standard of the target area is as follows: when the gradient value of a pixel point in the gradient image belongs to the threshold value interval, the pixel point belongs to the ith target area;
s43: through 4 sampling layers M 1 ,M 2 ,M 3 ,M 4 Sampling and extracting 4 target areas in each grade of cornea topographic map output by the 4 convolution layers respectively;
s44: marking 4 target areas extracted by the sampling layer through the full-connection layer, wherein the 1 st target area is marked as a red area, the 2 nd target area is marked as a yellow area, the 3 rd target area is marked as a green area and the 4 th target area is marked as a blue area; simultaneously compressing 4 target areas into one-dimensional vectors, and finally outputting the vectors through an output layer to finish training a neural network, wherein a full-connection layer is activated by adopting a softmax function;
S45: according to the S44, 4 target areas are corresponding to cornea topographic maps of each grade of myopes of 4 different diopter grades, and 4 cornea test areas are divided.
6. The method of claim 5, wherein the dividing of the cornea test zone comprises:
the corneal height interval in the corneal topography corresponding to the ith target area is:
e′ i ∈[e i-1 ,e i )，i∈{1,2...4}；
wherein e' i A corneal elevation value in the corneal topography corresponding to the ith target area;
e i the upper limit value of the cornea height section in the cornea topographic map corresponding to the ith target area;
e i-1 the lower limit value of the cornea height section in the cornea topographic map corresponding to the ith target area.
7. The method for testing the performance of a cornea shaping lens with a tesla valve-shaped round hole unit according to claim 1, wherein the cornea shaping lens comprises: the cornea shaping lens comprises a cornea shaping lens, a central round dot, a peripheral round dot, a central round dot, a circular arc unit, a circular hole unit, a positioning arc unit and a positioning arc unit, wherein the circular holes are arranged in a Tesla valve shape on the surface of the central round dot to the outer round ring in sequence, and the circular holes are arranged in the Tesla valve shape on the surface of the central round dot to the peripheral round dot.
8. The method for testing the performance of the cornea shaping lens with the tesla valve-shaped round hole unit according to claim 1, wherein the construction of the gain tension signal analysis model comprises the following specific steps:
s71: constructing a gain tension signal analysis unit, comprising: the cross section of one round hole in the reverse arc zone of the cornea shaping lens, and the volume between the cornea shaping lens and the cornea is v 1 Unit corneal epithelial cell one and unit corneal epithelial cell two-phase contact surface of cornea；
Wherein the cross section of the round hole is provided with a radius r 1 The sphere center is point O 1 A noon tangent plane of the ball I, the upper and lower tangent points are point A respectively 1 And point A 2 The method comprises the steps of carrying out a first treatment on the surface of the The contact surface of the cornea unit is a radius r 2 The sphere center is point O 2 One noon tangent plane of the ball two, the upper and lower tangent points are point B respectively 1 And point B 2 ；
Wherein, line A 1 A 2 For point A 1 And point A 2 Line B of (C) 1 B 2 For point B 1 And point B 2 Line O of (C) 1 O 2 Is point O 1 And point O 2 Is connected with the connecting line of the (a);
wherein point O 1 In straight line A 1 A 2 Point O on the left side of (2) 2 In straight line B 1 B 2 Right side of (2);
wherein, straight line O 1 O 2 Length D of (2) 2 Point A 1 And point A 2 With respect to straight line O 1 O 2 Symmetry, point B 1 And point B 2 With respect to straight line O 1 O 2 Symmetrical;
s72: constructing a two-dimensional plane coordinate system of a gain tension signal analysis unit, wherein the center of the cross section of a round hole in the cornea shaping lens is the origin of the two-dimensional plane coordinate system, and the straight line O 1 O 2 Is the x-axis of a two-dimensional plane coordinate system, straight line A 1 A 2 Is the y-axis of a two-dimensional plane coordinate system, wherein the point O 1 To O 2 Is in the positive direction of the x-axis, point A 2 To point A 1 Is the positive direction of the y axis;
wherein the unit corneal epithelial cells form two arc functions between the cornea shaping lens and the cornea asy > 0, f (x) and g (x) are about a straight line O 1 O 2 Symmetrical, x is the abscissa of a point in a two-dimensional plane coordinate system, and y is the ordinate of a point in the two-dimensional plane coordinate system;
wherein, unit angleThe upper contact angle of the membrane epithelial cells and the inner surface of the cornea shaping lens is alpha 1 An upper contact angle alpha with the outer surface of the cornea 2 The method comprises the steps of carrying out a first treatment on the surface of the The upper filling angle of the unit cornea epithelial cells and the inner surface of the cornea shaping lens is beta 1 Upper contact angle beta with the outer surface of cornea 2 。
9. The method for testing the performance of a cornea shaping lens with a tesla valve-shaped round hole unit according to claim 8, wherein the analysis of the gain tension signal of the cornea test zone comprises the following specific steps:
s81: area S of cross section of the round hole A The calculation strategy of (2) is as follows:
S A ＝2πr 1 2 ×(sinβ 1 ) 2 ；
wherein pi is the circumference ratio;
area S of the contact surface of the unit cornea with which the unit cornea epithelial cells come into contact B The calculation strategy of (2) is as follows:
S B ＝2πr 2 2 ×(sinβ 2 ) 2 ；
S82: volume v 1 The calculation strategy for the total contact area of unit corneal epithelial cell one with unit corneal epithelial cell two and unit corneal epithelial cell three is as follows:
wherein S is 2 Is the contact area of the unit corneal epithelial cell II and the unit corneal epithelial cell I;
S 3 the contact area of the unit corneal epithelial cells III and the unit corneal epithelial cells I;
is the upper tangent point B 1 Is the abscissa of (2); pi is the circumference ratio;
f (x) is the arcuate function formed by the unit corneal epithelial cells between the cornea shaping lens and the cornea;
to be in interval->Integrating the x;
f' (x) is the derivative of f (x);
s83: calculating the gain tension of the cornea shaping lens on the cornea, wherein the cornea gain tension F tm The calculation strategy of (2) is as follows:
wherein F is tm Cornea gain tension of a gain tension signal analysis unit;
F co intrinsic attractive force as a unit of corneal epithelial cell molecule;
e is the constant internal free energy of a gain tension signal analysis unit;
Δf is the shear force generated under the influence of eyelid pressure and squeeze film force;
Δp tm-co is the difference between the pressure of the anterior chamber of the eyeball to the cornea and the pressure of the eyelid to the cornea when the eyelid is naturally closed;
Δp co-co a difference in hydrostatic pressure of tear molecules between the first unit corneal epithelial cell and the second unit corneal epithelial cell;
v is the volume of the unit corneal epithelial cells; d (D) 2 Is O 1 With O 2 A linear distance therebetween;
phi is the contact coefficient, where
10. A method according to claim 9A method for testing performance of a cornea shaping lens with a Tesla valve-shaped round hole unit is characterized in that the hydrostatic pressure difference delta p of tear molecules between a first unit cornea epithelial cell and a second unit cornea epithelial cell co-co The calculation strategy of (2) is as follows:
wherein mu 0 Is the viscosity coefficient of tear molecules; pi is the circumference ratio;
v is the viscosity coefficient of the inner surface of the cornea shaping lens;
d is the diameter of the lens of the cornea shaping lens;
h is the maximum thickness of the tear layer; the thickness of the alpha tear layer is the average.
11. The method for testing the performance of the cornea shaping lens with the tesla valve-shaped round hole unit according to claim 10, wherein the determination of parameters of the round hole made by the photoetching machine comprises the following steps:
diameter d of round hole hole,J Is d hole,J ＝2r 1 ×sinβ 1 ×J,J∈{1,2}；
Depth h of round hole hole Is h hole ＝r 1 ×(1-cosβ 1 )；
Number of circular holes N in each cornea test zone hole Is that
Wherein G is f Is the oxygen-containing concentration in the anterior chamber of the eyeball; μ is the corneal height difference coefficient;
e′ i a cornea height value in the cornea topographic map corresponding to the ith target area;
e 4 the upper limit value of the cornea height interval in the cornea topographic map corresponding to the 4 th target area;
Epsilon is the oxygen permeability coefficient of the material used by the cornea shaping lens;
G o is the oxygen concentration in the air around the eyelid;
h is the thickness of the cornea shaping lens after the reverse arc is removed;
wherein, when j=1, d hole,1 The diameter of the small-aperture round hole;
when j=2, d hole,2 Is the diameter of a large-aperture round hole.
12. The method for testing the performance of the cornea shaping lens with the tesla valve-shaped round hole unit according to claim 11, wherein the simulation test of the working performance of the cornea shaping lens comprises the following steps:
the calculation strategy for the gain Δt of the cornea recovery time is as follows:
wherein K is the tension elastic coefficient of the material used by the cornea shaping lens;
C 1 radius of curvature of cornea for myopic patient, C 2 Radius of curvature for a cornea shaping mirror;
a is the surface area of the concave surface of the cornea shaping mirror.
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| US20090141235A1 (en) * | 2005-02-15 | 2009-06-04 | Queensland University Of Technology | Control of Myopia Using Contact Lenses |
| CN102129132A (en) * | 2011-03-29 | 2011-07-20 | 南开大学 | Design method for cornea contact lens based on wave front technology |
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| CN106291976A (en) * | 2015-07-24 | 2017-01-04 | 爱博诺德（北京）医疗科技有限公司 | The preparation method of the aspheric surface vision correction mirror that a kind of periphery out of focus is controlled |
| CN109581690A (en) * | 2018-12-25 | 2019-04-05 | 天津医科大学眼科医院 | Eyeglass, glasses and acquisition defocusing amount parameter, the method with mirror and Evaluated effect |
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| US20090141235A1 (en) * | 2005-02-15 | 2009-06-04 | Queensland University Of Technology | Control of Myopia Using Contact Lenses |
| CN102129132A (en) * | 2011-03-29 | 2011-07-20 | 南开大学 | Design method for cornea contact lens based on wave front technology |
| CN102508944A (en) * | 2011-10-10 | 2012-06-20 | 沈阳理工大学 | Corneal surface shape fitting method |
| CN106291976A (en) * | 2015-07-24 | 2017-01-04 | 爱博诺德（北京）医疗科技有限公司 | The preparation method of the aspheric surface vision correction mirror that a kind of periphery out of focus is controlled |
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