CN117307437A - IEAP-based electroactive pump for drug microinjection - Google Patents
IEAP-based electroactive pump for drug microinjection Download PDFInfo
- Publication number
- CN117307437A CN117307437A CN202311111997.3A CN202311111997A CN117307437A CN 117307437 A CN117307437 A CN 117307437A CN 202311111997 A CN202311111997 A CN 202311111997A CN 117307437 A CN117307437 A CN 117307437A
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- China
- Prior art keywords
- driver
- pump
- ieap
- microinjection
- injection
- Prior art date
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- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 238000000520 microinjection Methods 0.000 title claims abstract description 17
- 229940079593 drug Drugs 0.000 title claims abstract description 16
- 238000002347 injection Methods 0.000 claims abstract description 32
- 239000007924 injection Substances 0.000 claims abstract description 32
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims description 9
- 229920000554 ionomer Polymers 0.000 claims description 7
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000002390 adhesive tape Substances 0.000 claims description 3
- -1 polypropylene Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 230000008569 process Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229920001746 electroactive polymer Polymers 0.000 description 2
- 229920000831 ionic polymer Polymers 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
- F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
- F04B17/04—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors using solenoids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
- F04B53/16—Casings; Cylinders; Cylinder liners or heads; Fluid connections
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
- F04B53/16—Casings; Cylinders; Cylinder liners or heads; Fluid connections
- F04B53/162—Adaptations of cylinders
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
- F04B53/22—Arrangements for enabling ready assembly or disassembly
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to an injection pump, and aims to provide an electroactive pump for drug microinjection based on IEAP (injection-injection) so as to realize drug microinjection by driving the IEAP. The technical proposal is that the electroactive pump for drug microinjection based on IEAP comprises an injection pump arranged on a controller; the method is characterized in that: three spiral drivers are arranged in the injection pump; the driver is made of IEAP material; the controller is electrically connected with the driver through a wire, and outputs square wave and sine wave signals with adjustable amplitude and frequency to enable the driver to stretch and retract so as to output liquid medicine.
Description
Technical Field
The invention relates to an injection pump, in particular to an electroactive pump for drug microinjection based on IEAP.
Background
The microinjection pump (micropump for short) is a new type pumping force instrument for pumping small quantity of medicine liquor into human body accurately, uniformly and continuously, and its operation is convenient, timing and quantitative, and according to the condition requirements the medicine concentration and speed can be regulated at any time so as to make the medicine retain effective blood concentration in the human body. The critical patients are rescued by the micro pump, the workload of nurses can be reduced, the working efficiency is improved, and the micro pump can be accurately, safely and effectively matched with doctors for rescuing.
The injection pump leaves beautiful figure in various industries; the method can be applied to scenes such as mass spectrometry, micro-flow control, stereotactic injection and the like in a laboratory; the medical composition can be used for the fields of neonatal nutrition supply, blood transfusion, anticoagulant, anesthetic and other liquid medicine input and the like in clinical medical treatment. A common syringe pump is a medical instrument composed of a stepping motor and a driver, a screw rod, a bracket and the like. When the injection pump works, the control system sends out a pulse control signal to enable the stepping motor to work, the stepping motor drives the screw rod to rotate, and the piston of the injector is pushed to inject and convey liquid. However, most syringe pumps require a relatively large piston plunger motor and a heavy battery, which is expensive.
The ionic electroactive polymer material (Ionic Electroactive Polymers, IEAP) is an intelligent electrically driven material that can replace electric motors to convert electrical energy into mechanical energy, known as "ionic artificial muscle". The IEAP driver has the characteristics of low driving voltage, relatively large mechanical deformation, light weight, good flexibility, quick response time, wide frequency bandwidth and the like. According to these remarkable features, the IEAP driver may be applied in the fields of micro-soft robots, medical machines for in vivo use, wearable devices, surgical tools, health detection, etc. Nowadays, IEAP-based flexible biomimetic robots, flexible grippers, flexible sensors, etc. have been implemented, but the application in the field of medical devices is quite lacking.
Disclosure of Invention
The invention aims to overcome the defects in the background technology and provide an electroactive pump for drug microinjection based on IEAP, which realizes drug microinjection by driving the IEAP.
The technical scheme of the invention is as follows:
an IEAP-based electroactive pump for microinjection of a drug comprising a syringe pump disposed on a controller; the method is characterized in that: three spiral drivers are arranged in the injection pump; the driver is made of IEAP material; the controller is electrically connected with the driver through a wire, and outputs square wave and sine wave signals with adjustable amplitude and frequency to enable the driver to stretch and retract so as to output liquid medicine.
And two ends of the driver are respectively fixed with a piston handle and an end plate of the injection pump through polypropylene double faced adhesive tape.
The drivers are uniformly arranged around the central axis of the injection pump; the central axis of the driver is parallel to the central axis of the injection pump.
The driver includes an ionomer membrane in the middle and flexible electrodes disposed on both sides of the ionomer membrane.
The controller is electrically connected with the right end of the driver through a wire.
The working principle of the invention is as follows:
the three spiral drivers are arranged inside the injection pump and are arranged in a triangular mode, and when voltage is applied to the drivers, the drivers can drive the piston handle to move; when a positive voltage is applied, the driver positively deforms to push the piston handle to generate thrust to pump out liquid medicine, so that medicine injection is realized, when the voltage is disconnected, the driver stops deforming, injection is paused, and when a negative voltage with the same amplitude is applied, the three drivers gradually recover from the deformation.
The beneficial effects of the invention are as follows:
the IEAP driver adopted by the invention takes cellulose as a substrate, and is environment-friendly, low in cost and excellent in performance; the driver is of a spiral structure, the deflection of the driver is converted into axial bending deformation, and microinjection of the pump is realized; the controller outputs square wave and sine wave signals with adjustable amplitude and frequency to enable the driver to stretch; the invention has simple structure, convenient assembly and small volume, and provides a certain reference meaning for the application of the IEAP in the medical field.
Drawings
Fig. 1 is a schematic perspective view of the present invention.
Fig. 2 is a schematic representation of the deformation principle of the IEAP material of the present invention.
Fig. 3-1 is one of the schematic diagrams of the screw drive of the present invention (unpowered state).
Fig. 3-2 is a second schematic view of the screw driver of the present invention (on positive voltage deformed state).
Fig. 3-3 are three schematic diagrams of the screw driver of the present invention (on negative voltage deformed state).
Fig. 4 is a schematic cross-sectional view of a syringe pump of the present invention.
Fig. 5 is a schematic axial cross-section of the syringe pump of the present invention.
Reference numerals: the injection pump 1, the controller 2, the piston 3, the piston shaft 4, the driver 5, the ionic polymer membrane 5-1, the flexible electrode 5-2, the end plate 6, the hollow cylinder 7 and the piston handle 8.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
As shown in fig. 1, an IEAP-based electroactive pump for microinjection of a drug comprises a syringe pump 1 and a controller 2.
The injection pump is arranged on the controller. The syringe pump comprises a hollow cylinder 7, a piston 3 arranged in the hollow cylinder, and a piston handle 8 connected to the piston through a piston shaft 4. The left end of the hollow cylinder 7 is provided with a liquid medicine outlet, and the right end of the hollow cylinder 7 is provided with an end plate 6.
Three drivers 5 are arranged in the injection pump and are arranged on the right side of the piston handle, the drivers are made of IEAP materials, the three spiral drivers are identical in size and are spirally bent, and two ends of each driver are respectively fixed with the piston handle and the end plate through polypropylene double faced adhesive tape.
The drivers are uniformly arranged around the central axis of the syringe pump (horizontal axis of fig. 5), and the central axis of the drivers is parallel to the central axis of the syringe pump. The driver comprises an ionomer membrane 5-1 in the middle and flexible electrodes 5-2 arranged on both sides of the ionomer membrane.
The controller is electrically connected with the driver through a wire, and outputs square wave and sine wave signals with adjustable amplitude and frequency to enable the driver to stretch and retract so as to output liquid medicine. The controller is electrically connected to the right end (flexible electrodes on both sides) of the driver by wires.
The controller (in the prior art, which is not described in detail) comprises a singlechip, a voltage stabilizing module, a signal amplifying module and a control switch. The controller adopts a polymer lithium battery or a USB port to supply power and can automatically switch the power supply.
The driver shown in fig. 2 (prior art; see ZL 202211087289.6) is a "sandwich" three-layer structure consisting of two flexible electrodes on both sides and an ionomer membrane in the middle. The ionic polymer membrane takes microfibrillated cellulose (MFC) as a substrate, has high flexibility and green degradability, and is very suitable for preparing ionic electroactive drivers; besides, ionic liquid, polyvinyl alcohol, and other high polymer materials are doped, so that the physical property and the electrochemical property of the driver are obviously enhanced. The driver has the advantages of large deformation, quick response, strong durability and the like. Experiments prove that the driver shows the maximum deformability under the alternating current (direct current) voltage of 2V.
The driver is manufactured by a thermoplastic method: firstly, preparing a strip-shaped MFC-IL-PVA flexible driver, then winding the MFC-IL-PVA flexible driver on a special smooth die, and finally, placing the MFC-IL-PVA flexible driver in a vacuum drying oven at 65 ℃ for heat treatment for 12 hours to eliminate stress, so that the MFC-IL-PVA flexible driver becomes a screw driver.
The drive unpowered state is shown in fig. 3-1.
The state of the driver when the +2V voltage is applied is shown as figure 3-2, the driver is axially elongated and radially thinned, and the driver axially elongated pushes the piston handle to squeeze the liquid medicine in the injection process of the injection pump so as to realize injection.
The state of the actuator when the-2V voltage is applied is shown in fig. 3-3, and the actuator is shortened in the axial direction and thickened in the radial direction, and the piston returns through the axial shortening in the injection process of the injection pump.
The side force of the electroactive pump is shown in figure 4, and the three drivers are in a triangular force structure, so that the force on the surfaces of the drivers is more uniform, and the drivers can push the piston to move by using the axial force of the drivers as much as possible.
The injection process of the electroactive pump may be divided into three phases.
The first stage: all three drivers are not electrified, and the electroactive pump is in a free stage;
and a second stage: when the controller provides positive voltage with certain amplitude and frequency, the three drivers are driven to deform and are axially elongated and radially thinned, so that the piston handle is pushed to squeeze the liquid medicine in the injection pump to release the medicine;
and a third stage: when a fixed amount of medicine is input, the controller interrupts the voltage, the driver stops deforming, and the medicine injection is suspended;
fourth stage: when the injection of the drug is completed, the drive means provides a negative voltage of the same magnitude and frequency, the drive means acting as an axially shortened, radially thickened drive means by the action of the electric charge, causing the plunger shaft to return to its original position.
The controller can change the waveform, frequency and amplitude of the output signal according to different situations and different volumes of medicine injection.
Compared with the existing pump, the electroactive pump has the following advantages:
1. the driver is based on ionic artificial muscles, so that the driver is lighter and environment-friendly;
2. the structure is simple, the operation is convenient, and the device is suitable for various application scenes;
3. the driver can work at low voltage of about 1-2V;
4. is a breakthrough of the novel material in the medical field, expands the application range of the novel material, and lays a foundation for the comprehensive use of medical equipment and materials in the future.
Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Claims (5)
1. An IEAP-based electroactive pump for microinjection of a drug comprising a syringe pump (1) arranged on a controller (2); the method is characterized in that: three spiral drivers (5) are arranged in the injection pump; the driver is made of IEAP material; the controller is electrically connected with the driver through a wire, and outputs square wave and sine wave signals with adjustable amplitude and frequency to enable the driver to stretch and retract so as to output liquid medicine.
2. An IEAP-based electroactive pump for microinjection of drugs according to claim 1, wherein: and two ends of the driver are respectively fixed with a piston handle and an end plate of the injection pump through polypropylene double faced adhesive tape.
3. An IEAP-based electroactive pump for microinjection of drugs according to claim 2, characterized in that: the drivers are uniformly arranged around the central axis of the injection pump; the central axis of the driver is parallel to the central axis of the injection pump.
4. An IEAP-based electroactive pump for microinjection of drugs according to claim 3, characterized in that: the driver comprises an ionomer membrane (5-1) in the middle and flexible electrodes (5-2) arranged on both sides of the ionomer membrane.
5. An IEAP-based electroactive pump for microinjection of drugs according to claim 4, wherein: the controller is electrically connected with the right end of the driver through a wire.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311111997.3A CN117307437A (en) | 2023-08-31 | 2023-08-31 | IEAP-based electroactive pump for drug microinjection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311111997.3A CN117307437A (en) | 2023-08-31 | 2023-08-31 | IEAP-based electroactive pump for drug microinjection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117307437A true CN117307437A (en) | 2023-12-29 |
Family
ID=89280217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311111997.3A Pending CN117307437A (en) | 2023-08-31 | 2023-08-31 | IEAP-based electroactive pump for drug microinjection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117307437A (en) |
-
2023
- 2023-08-31 CN CN202311111997.3A patent/CN117307437A/en active Pending
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| PB01 | Publication | ||
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