CN117287800A - System and method for precisely controlling pressure difference in clean area of medicine production workshop - Google Patents

System and method for precisely controlling pressure difference in clean area of medicine production workshop Download PDF

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Publication number
CN117287800A
CN117287800A CN202310129789.XA CN202310129789A CN117287800A CN 117287800 A CN117287800 A CN 117287800A CN 202310129789 A CN202310129789 A CN 202310129789A CN 117287800 A CN117287800 A CN 117287800A
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pressure
clean
air
preset
gas
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王伟
张雪松
徐磊磊
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Shanghai Langmai Intelligent Control Technology Co ltd
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Shanghai Langmai Intelligent Control Technology Co ltd
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Priority to CN202310129789.XA priority Critical patent/CN117287800A/en
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/0001Control or safety arrangements for ventilation
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/62Control or safety arrangements characterised by the type of control or by internal processing, e.g. using fuzzy logic, adaptive control or estimation of values
    • F24F11/63Electronic processing
    • F24F11/64Electronic processing using pre-stored data
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/70Control systems characterised by their outputs; Constructional details thereof
    • F24F11/72Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure
    • F24F11/74Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure for controlling air flow rate or air velocity
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/70Control systems characterised by their outputs; Constructional details thereof
    • F24F11/72Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure
    • F24F11/74Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure for controlling air flow rate or air velocity
    • F24F11/77Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure for controlling air flow rate or air velocity by controlling the speed of ventilators
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/89Arrangement or mounting of control or safety devices
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24HEATING; RANGES; VENTILATING
    • F24FAIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F11/00Control or safety arrangements
    • F24F11/0001Control or safety arrangements for ventilation
    • F24F2011/0002Control or safety arrangements for ventilation for admittance of outside air
    • F24F2011/0005Control or safety arrangements for ventilation for admittance of outside air to create underpressure in a room, keeping contamination inside

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Fluid Mechanics (AREA)
  • Ventilation (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)

Abstract

The invention discloses a system and a method for precisely controlling the pressure difference of a clean area in a medicine production workshop, wherein the system comprises a blower, an exhaust fan, a return air quantity detection device, an air quantity control valve, a differential pressure meter, an air flowmeter, an angle sensor and a monitoring module, wherein the monitoring module stores a preset pressure value range and preset regulating time of each clean area, when the monitoring module detects that the actual pressure value of the clean area is out of the preset pressure value range, the monitoring module generates a corresponding control instruction based on the magnitude of a deviation value and the preset regulating time, and the control module receives the control instruction and regulates the rotating speed of the exhaust fan and the opening degree of the air quantity control valve according to the control instruction.

Description

System and method for precisely controlling pressure difference in clean area of medicine production workshop
Technical Field
The invention relates to the technical field of clean zone differential pressure control, in particular to a system and a method for precisely controlling the differential pressure of a clean zone in a pharmaceutical production workshop.
Background
The clean room is a specially designed room which eliminates pollutants such as particles, harmful gases, bacteria and the like in the gas in a certain space range, and controls the indoor temperature, humidity, cleanliness, pressure difference, air quantity, air flow speed, air flow distribution, noise, vibration, illumination and static electricity in relevant standard requirement ranges.
The design requirement meeting the pressure difference gradient is a hardness index in the medicine production workshop, and the pressure difference gradient refers to four grades A, B, C, D for clean distinction of the medicine production workshop. A comprises B, B comprises C, C is outside, and the air flow path is from a to B to C to D to outside, then the room pressure in A, B, C, D is increased along a gradient according to a certain pressure; in actual production, the requirements of the specifications must be met to allow pharmaceutical production. How to ensure different clean class zones, and the gradient of pressure differences between different functions in the zones, is a very important part of BMS/EMS systems.
The existing negative pressure clean room differential pressure control generally adopts a fixed-feeding and variable-discharging mode, namely, the air quantity fed into the clean room is kept unchanged, the pressure of the clean room is regulated by changing the air quantity and the air return quantity of the clean room, a valve is generally installed in an exhaust pipe of the clean room at present, the air quantity of the exhaust pipe is regulated by regulating the opening degree of the valve, but under the condition that the actual pressure of the clean room is far higher than the set pressure, the quick recovery of the pressure of the clean room cannot be realized only by regulating the valve, and when a door of the clean room is opened, because of the pressure difference between the clean rooms, gas flows between adjacent clean rooms, and when the door is closed, the pressure of the clean room is regulated again, a certain hysteresis exists, so that the risk of outward flow of the gas in the clean room is necessarily increased.
Disclosure of Invention
In order to solve the problems, the invention provides a system and a method for precisely controlling the pressure difference of a clean area of a medicine production workshop, which are used for solving the problems that the pressure of the clean room cannot be quickly adjusted only by a valve in the prior art, and the risk of cross contamination of the clean room is increased.
In order to achieve the above purpose, the technical scheme of the pressure difference accurate control system for the clean area of the medicine production workshop is as follows: comprising
The air feeder is connected with each clean zone through an air supply pipeline and is used for feeding gas into each clean zone;
the exhaust fans are respectively connected with each clean area through exhaust pipelines and are used for exhausting gas in the clean areas;
the air return quantity detection device is used for detecting the air return quantity of the clean room;
the air quantity control valve is arranged in each exhaust pipeline, and the air quantity passing through the exhaust pipeline is improved by increasing the opening of the air quantity control valve;
the differential pressure gauge is arranged in each clean zone and is used for detecting the absolute differential pressure between the clean zone and the external environment;
the air flow meter is arranged on a door between the air exhaust pipeline and the adjacent clean area, and is used for respectively acquiring and recording a first air flow rate passing through the air exhaust pipeline in unit time and a second air flow rate passing through the door when the door is opened when the air volume control valve is positioned at different openings;
The angle sensor is arranged on the door and is used for detecting the opening angle of the door;
the monitoring module is connected with the exhaust fan, the differential pressure gauge, the gas flowmeter and the angle sensor, a preset pressure value range and a preset adjusting time of each clean area are stored in the monitoring module, when the monitoring module detects that the actual pressure value of the clean area is out of the preset pressure value range, the monitoring module generates a corresponding control instruction based on the magnitude of the deviation value and the preset adjusting time, when the door is opened, the monitoring module adjusts the first gas flow rate based on the second gas flow rate so as to reduce fluctuation of pressure in the clean area, and when the monitoring module determines that the door is opened through a first formula, the first module generates a corresponding control instruction based on the magnitude of the deviation valueThe first formula is as follows:wherein Q is 2 For the second gas flow rate, h is the height of the door, w is the width of the door, θ is the opening angle of the door, and s is the sectional area of the exhaust duct; the method comprises the steps of carrying out a first treatment on the surface of the
And the control module receives the control instruction, and adjusts the rotating speed of the exhaust fan and the opening of the air quantity control valve according to the control instruction so as to adjust the pressure in the clean area.
Further, at least, including clean district A, clean district B, clean district C and clean district D, be located every clean district top and with the constant pressure chamber that the pressure differential meter corresponds the setting, be located respectively steady voltage chamber W1-W4 of clean district A-D top, be located the inflating cavity C1 of steady voltage chamber W1 and steady voltage chamber W2 top, be located inflating cavity C2 on steady voltage chamber W3 and the steady voltage chamber W4, set up first manometer in inflating cavity C1, set up the second manometer in inflating cavity C2, inflating cavity C1 with inflating cavity C2 respectively through first valve and second valve with the forced draught blower is connected, be provided with down the pressure differential valve between every clean district and the steady voltage chamber, be provided with the pressure differential valve between every steady voltage chamber and the inflating chamber, be provided with the manometer in the inflating chamber, control module is based on the pressure value of first manometer and second manometer, with the pulse mode first valve and second valve are in order to keep inflating cavity C1 with inflating cavity C2 and pressure differential valve P is the pressure of pressure differential valve P is opened when the steady voltage chamber C1 is the pressure differential valve P is set up to the pressure of steady voltage chamber P is the pressure of pressure chamber and is the corresponding to the pressure differential valve P-P is more than the pressure of the steady voltage chamber is set up to the pressure P-4 when the pressure is the pressure of the clean district is the pressure is the corresponding to the pressure of the pressure is the pressure of the pressure (is the pressure-1-4 is respectively opened.
Further, the invention also provides a method for precisely controlling the pressure difference of the clean area of the medicine production workshop, which is realized based on the control system, and comprises the following steps:
step S1, obtaining a pressure relation function V 0 =f(P 1 -P 2 ) WhereinV 0 For cleaning the room from the first pressure value P 1 Reaching the second pressure value P 2 The volume of gas required;
step S2, the monitoring module acquires an actual pressure value of a clean zone, judges whether the actual pressure value is lower than the lower limit of the preset pressure value range, if yes, the monitoring module calculates the gas volume required by the clean room from the actual pressure value to the lower limit of the preset pressure value range based on a pressure relation function, and reduces the opening of the air volume control valve according to the required gas volume and the preset adjusting time, and if not, the step S3 is executed;
and S3, the monitoring module judges whether the actual pressure value is higher than the upper limit of the preset pressure value range, and if so, the monitoring module calculates the volume of gas required by the clean room from the actual pressure value to the upper limit of the preset pressure value range based on a pressure relation function, and increases the opening of the air quantity control valve and the rotating speed of the exhaust fan according to the required volume of gas and the preset adjusting time.
Further, the step S2 includes: the monitoring module obtains the actual pressure value of each clean zone, judges whether the actual pressure value is lower than the lower limit of the preset pressure value range, when the actual pressure value is lower than the lower limit of the preset pressure value range, the monitoring module calculates the gas volume required by the clean chamber from the actual pressure value to the lower limit of the preset pressure value range based on a pressure relation function, meanwhile judges whether the gas in the corresponding pressure stabilizing cavity is greater than the required gas volume, when the gas in the pressure stabilizing cavity is greater than the required gas volume, the blower inflates the inflation cavity, when the gas in the pressure stabilizing cavity is not greater than the required gas volume, the opening of the air volume control valve is reduced according to the required gas volume, the difference between the pressure stabilizing cavity and the required volume and the preset regulating time, and when the actual pressure value is not lower than the lower limit of the preset pressure value range, the step S3 is executed.
Further, in the step S1, a pressure relation function is determined according to the space size of the denuded zone, the gas temperature and the amount of gas substances.
Further, in step S2, a minimum opening is preset in the air volume control valve, and the minimum opening is 15% of the total opening of the air volume control valve.
Further, in the step S3, after the monitoring module obtains the gas volume required by the clean room from the actual pressure value to the upper limit of the preset pressure value range, the monitoring module determines whether the required gas volume satisfies a second formula, if yes, the monitoring module adjusts the opening of the air volume control valve to the upper limit, and increases the rotational speed of the exhaust fan according to the required gas volume, if no, the monitoring module only increases the opening of the air volume control valve, where the second formula is: v (V) 0 |>V 2 +V 3 -V 1 Wherein V is 1 、V 2 、V 3 The current blower rotating speed, the current exhaust fan rotating speed and the current air quantity control valve are respectively in the condition of maximum opening, and in the preset adjusting time, the air supply volume of the blower, the air exhaust volume of the exhaust fan and the air return volume of the clean room are respectively.
Further, in the step S2, the monitoring module reduces the opening of the air volume control valve according to the required gas volume and the preset adjustment time, including the following steps:
step S21, the monitoring module calculates the first gas flow rate Q required by the exhaust pipeline in unit time in the preset adjusting time through a third formula 1 The third formula is:wherein Q is 0 S is the sectional area of the exhaust pipeline and t is the preset adjusting time;
step S22, the monitoring module adjusts the opening degree of the air quantity control valve based on the relation between the first air flow rate and the opening degree of the air quantity control valve.
Further, the step S2 further includes: when the gas in the pressure stabilizing cavity is not larger than the required gas volume, the opening of the air quantity control valve is reduced according to the required gas volume, the difference between the pressure stabilizing cavity and the required volume and the preset adjusting time, and meanwhile, when the pressure of the clean room is close to a preset value, the rotating speed of the exhaust fan is reduced again, and the pressure of the clean room is adjusted through the pressure stabilizing cavity.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the invention, the preset pressure value range is set in the monitoring module, and when the actual pressure of the clean room is lower than the lower limit of the preset pressure value range, the opening degree of the air quantity control valve is reduced to reduce the air quantity of the air exhaust pipeline, so that the pressure of the clean room is increased; when the actual pressure in the clean room is higher than the upper limit of the preset pressure value range, the air outlet of the air exhaust pipeline is increased by increasing the opening of the air volume control valve, so that the pressure in the clean room is increased; the invention detects absolute pressure in the clean room through the differential pressure gauge, controls air outlet quantity of the clean room through the monitoring module, realizes intelligent regulation of the pressure in the clean room, and on the basis, the monitoring module can also intelligently regulate the rotating speed of the exhaust fan according to actual pressure, thereby realizing rapid regulation of the pressure in the negative pressure clean room.
2. Before the clean room is put into use, the air quantity of the air supply pipeline and the air exhaust pipeline is set according to the design and use pressure of the clean room and the gap size of the door and window of the clean room, namely the clean room is continuously ventilated while the pressure is maintained; in the second formula, first byCalculating a first gas flow rate in the exhaust duct to be reduced, and subtracting the required reduction based on the current first gas flow rateThereby obtaining a desired first gas flow rate; the desired gas volume derived based on the pressure relationship itself has positive and negative values, i.e. V when an increase in gas volume is desired 0 Positive, V when it is desired to reduce the gas volume 0 Is negative, so the second formula no longer has to be applied to V 0 Is limited by the sign of (2); after the first gas flow rate to be reduced is calculated through the second formula, the monitoring module records the corresponding relation between the first gas flow rate in the exhaust pipeline and the opening of the air volume control valve, so that the monitoring module can directly adjust the air volume control valve, and further intelligent adjustment of the air volume control valve is realized.
3. Therefore, when the door is opened, the opening degree of the air quantity control valve is synchronously adjusted, so that the air quantity and the air quantity of the clean room are kept in dynamic balance, the fluctuation of the pressure of the clean room is reduced, and the accurate adjustment of the pressure of the clean room is improved.
4. The invention can be matched with the constant pressure cavity to realize accurate determination of the pressure difference of the clean room, and can be matched with the upper and lower pressure difference valve, the pressure stabilizing cavity, the air charging cavity, the first valve, the second valve and the control module to regulate the pressure of the clean room in real time, so as to avoid continuous expansion of the pressure difference, and simultaneously supplement air to the clean room through the pressure stabilizing air in the pressure stabilizing cavity to maintain the pressure of the clean room.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a system for precisely controlling the differential pressure in a clean area of a pharmaceutical production plant according to the present invention;
FIG. 2 is a flow chart of a method for precisely controlling the differential pressure in a clean zone of a pharmaceutical production plant according to the present invention;
FIG. 3 is a schematic view of the clean room door of the present invention;
FIG. 4 is a schematic view of the structure of the plenum and plenum of the present invention and its vicinity.
In the figure: 1. a blower; 2. an exhaust fan; 3. an air volume control valve; 4. a differential pressure gauge; 5. a gas flow meter; 6. a monitoring module; 7. a control module; 8. an angle sensor; 9. a door; 10. a constant pressure chamber; 11. a first valve; 12. a second valve; 14. a first pressure gauge; 15. a second pressure gauge; 16. a top differential pressure valve; 17. a lower differential pressure valve.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
It will be understood that the terms "first," "second," and the like, as used herein, may be used to describe various elements, but these elements are not limited by these terms unless otherwise specified. These terms are only used to distinguish one element from another element. For example, a first xx script may be referred to as a second xx script, and similarly, a second xx script may be referred to as a first xx script, without departing from the scope of the present application.
Example 1
As shown in fig. 1, a system for precisely controlling a pressure difference in a clean zone of a pharmaceutical production plant, comprising: the air feeder 1 is connected with each clean zone through an air supply pipeline, and the air feeder 1 is used for feeding gas into each clean zone; the exhaust fan 2 is respectively connected with each clean zone through an exhaust pipeline, and the exhaust fan 2 is used for exhausting gas in the clean zones; a return air volume detecting device (not shown) for detecting the return air volume of the clean room; the air quantity control valve 3 is arranged in each exhaust pipeline, and the air quantity passing through the exhaust pipeline is improved by increasing the opening of the air quantity control valve 3, and the air quantity control valve 3 is a butterfly valve or a Venturi valve; the differential pressure gauge 4 is arranged in each clean zone, and the differential pressure gauge 4 is used for detecting the absolute differential pressure between the clean zone and the external environment; the air flow meter 5 is arranged in the air exhaust pipeline and the door 9, and the air flow meter 5 respectively acquires and records a first air flow rate passing through the air exhaust pipeline in unit time and a second air flow rate passing through the door 9 when the door 9 is opened when the air volume control valve 3 is positioned at different openings; the angle sensor 8 is arranged on the door 9, and the angle sensor 8 is used for detecting the opening angle of the door 9; the monitoring module 6 is connected with the exhaust fan 2, the differential pressure gauge 4, the gas flowmeter 5 and the angle sensor 8, a preset pressure value range and preset adjusting time of each clean zone are stored in the monitoring module 6, and when the monitoring module 6 detects that the actual pressure value of the clean zone is out of the preset pressure value range, the monitoring module 6 generates a corresponding control instruction based on the magnitude of the deviation value and the preset adjusting time; the control module 7 receives the control command and adjusts the rotating speed of the exhaust fan 2 and the opening of the air quantity control valve 3 according to the control command so as to adjust the pressure in the clean area.
As shown in fig. 3, in this embodiment, the monitoring module 6 adjusts the first gas flow rate based on the first gas flow rate when the door 9 is opened, so as to reduce the fluctuation of the pressure in the denuded zone. Specifically, the monitoring module 6 determines, according to a third formula, a first gas flow rate required by the exhaust duct when the door 9 is opened, where the first formula is:wherein Q is 2 For the second gas flow rate, h is the height of the door 9, w is the width of the door 9, θ is the opening angle of the door 9, and s is the sectional area of the exhaust duct.
When the door 9 of the clean room is opened, gas can flow between adjacent clean rooms due to pressure difference between the clean rooms, and certain hysteresis exists when the door 9 is closed and then the pressure of the clean room is regulated; therefore, when the door 9 is opened, the air quantity and the air discharge quantity of the clean room are kept in dynamic balance by synchronously adjusting the opening of the air quantity control valve 3, so that the fluctuation of the pressure of the clean room is reduced, the accurate adjustment of the pressure of the clean room is improved, and particularly, when the door 9 is opened,by cosine law, i.e.The distance between the upper side surface of the door 9 and the wall body is calculated, the distance is multiplied by the height of the door 9 to obtain the passing area of the gas under the opening theta angle, then the air quantity passing through the door 9 in unit time is calculated based on the second air flow rate passing through the door 9, and finally the first air flow rate required by the air exhaust pipeline is calculated based on the cross section area of the air exhaust pipeline, so that the opening degree of the air quantity control valve 3 is adjusted.
In the prior art, in order to ensure the pressure difference between clean rooms, the pressure of adjacent rooms is usually used as a reference for adjustment, so that the pressure difference between the clean rooms can be ensured, but the pressure of the clean rooms can be far higher than the reference pressure; when the pressure difference is offset and the pressure of the clean room needs to be increased, the actual pressure of the clean room may exceed the adjusting range of the control system, so that the absolute pressure difference between the clean room and the external environment is detected by the differential pressure gauge 4, and the pressure of the clean room is ensured not to exceed the adjusting range of the control system.
On the other hand, as shown in fig. 2, the invention also provides a method for precisely controlling the pressure difference of the clean area of the medicine production workshop, which is used for precisely controlling the pressure difference of the clean area of the medicine production workshop according to the technical scheme, and comprises the following steps,
step S1, obtaining a pressure relation function V 0 =f(P 1 -P 2 ) Wherein V is 0 For cleaning the room from the first pressure value P 1 Reaching the second pressure value P 2 The volume of gas required;
step S2, the monitoring module 6 acquires an actual pressure value of the clean zone, judges whether the actual pressure value is lower than the lower limit of the preset pressure value range, if yes, the monitoring module 6 calculates the gas volume required by the clean room from the actual pressure value to the lower limit of the preset pressure value range based on a pressure relation function, reduces the opening of the air quantity control valve 3 according to the required gas volume and the preset adjusting time, and if not, executes the step S3;
Step S3, the monitoring module 6 determines whether the actual pressure value is higher than the upper limit of the preset pressure value range, and if yes, the monitoring module 6 calculates the volume of gas required by the clean room from the actual pressure value to the upper limit of the preset pressure value range based on the pressure relation function, and increases the opening of the air volume control valve 3 and the rotational speed of the exhaust fan 2 according to the required volume of gas and the preset adjustment time.
According to the invention, the preset pressure value range is set in the monitoring module 6, and when the actual pressure of the clean room is lower than the lower limit of the preset pressure value range, the opening of the air quantity control valve 3 is reduced to reduce the air quantity of the air exhaust pipeline, so that the pressure of the clean room is increased; when the actual pressure in the clean room is higher than the upper limit of the preset pressure value range, the air outlet of the air exhaust pipeline is increased by increasing the opening of the air volume control valve 3, so that the pressure in the clean room is increased; the invention detects absolute pressure in the clean room through the differential pressure gauge 4, controls air outlet quantity of the clean room through the monitoring module 6, realizes intelligent regulation of the pressure in the clean room, and on the basis, the monitoring module 6 can also intelligently regulate the rotating speed of the exhaust fan 2 according to actual pressure, thereby realizing rapid regulation of the pressure in the negative pressure clean room.
In step S1, a pressure relationship function is determined based on the size of the space in the denuded zone, the gas temperature and the amount of gas species. Since the relationship between the mass and the pressure of the gas in the fixed space can be obtained by the gram-atom Long Fangcheng, after knowing the size of the clean area space, the temperature and the difference between the first pressure value and the second pressure value, the mass of the gas required for reaching the second pressure value from the first pressure value can be calculated based on the gram-atom Long Fangcheng, then the volume of the gas required for calculating the volume of the gas required based on the volume of the gas required, and the conversion between the pressure and the volume of the gas based on the gram-atom Long Fangcheng is a common technology in the art and will not be repeated here.
In this embodiment, in step S2, a minimum opening is preset in the air volume control valve 3, where the minimum opening is 15% of the total opening of the air volume control valve 3; through this setting, on the one hand make monitoring module 6 unable complete closure exhaust duct, still have certain gas circulation when guaranteeing the toilet at the boost pressure, on the other hand, when the degree of opening of air volume control valve 3 is too little, the risk of air volume control valve 3 cavitation can greatly increased, consequently can reduce the erosion of gas to air volume control valve 3 through setting up minimum aperture.
In step S3, after the monitoring module 6 obtains the gas volume required by the clean room from the actual pressure value to the upper limit of the preset pressure value range, the monitoring module 6 determines whether the required gas volume satisfies the second formula, if yes, the monitoring module 6 adjusts the opening of the air volume control valve 3 to the upper limit, and increases the rotational speed of the exhaust fan 2 according to the required gas volume, if no, the monitoring module 6 only increases the opening of the air volume control valve 3, where the second formula is: v (V) 0 |>V 2 +V 3 -V 1 Wherein V is 1 、V 2 、V 3 The current rotating speed of the blower 1, the rotating speed of the exhaust fan 2 and the maximum opening of the air quantity control valve 3 are respectively, and the air supply volume of the blower 1, the air exhaust volume of the exhaust fan 2 and the return air volume of the clean room are respectively within the preset adjusting time.
Judging whether the pressure of the clean room can be reduced to be within a preset pressure value range only through the air quantity control valve 3 in a preset adjusting time through the formula; when |V 0 |<V 2 +V 3 -V 1 When the air quantity of the air exhaust pipeline in the preset time can reach the air exhaust quantity for reducing the pressure of the clean room to the upper limit of the preset range when the opening of the air quantity control valve 3 is regulated to the maximum under the current rotating speed of the exhaust fan 2, the pressure of the clean room can be quickly regulated only by regulating the opening of the air quantity control valve 3 under the condition; when |V 0 |>V 2 +V 3 -V 1 When the air quantity control valve 3 is adjusted to the maximum opening degree under the current rotating speed of the exhaust fan 2, the air quantity of the air exhaust pipeline in the preset time still cannot reach the purpose of reducing the pressure of the clean room to the preset rangeIn this case, the rotational speed of the exhaust fan 2 must be increased to achieve rapid adjustment of the clean room pressure when the opening of the air volume control valve 3 is adjusted to the maximum.
In step S2, the monitoring module 6 reduces the opening of the air volume control valve 3 according to the required volume of the gas and the preset adjustment time, including the following steps:
step S21, the monitoring module 6 calculates a first gas flow rate Q required by the exhaust pipeline in unit time in a preset adjusting time through a third formula 1 The third formula is:wherein Q is 0 T is preset adjusting time for the first gas flow rate in the current exhaust pipeline;
in step S22, the monitoring module 6 adjusts the opening degree of the air volume control valve 3 based on the relationship between the first air flow rate and the opening degree of the air volume control valve 3.
Before the clean room is put into use, the air quantity of the air supply pipeline and the air exhaust pipeline is set according to the design and use pressure of the clean room and the gap size of the door and window of the clean room, namely the clean room is continuously ventilated while the pressure is maintained; in the second formula, first by Calculating a first gas flow rate required to be reduced in the exhaust pipeline, and subtracting the first gas flow rate required to be reduced based on the current first gas flow rate, so as to obtain the required first gas flow rate; the desired gas volume derived based on the pressure relationship itself has positive and negative values, i.e. V when an increase in gas volume is desired 0 Positive, V when it is desired to reduce the gas volume 0 Is negative, so the second formula no longer has to be applied to V 0 Is limited by the sign of (2); after the first gas flow rate to be reduced is calculated by the second formula, the monitoring module 6 records the corresponding relationship between the first gas flow rate in the exhaust pipeline and the opening of the air volume control valve 3, so that the monitoring module can directly control the air volume control valve 3And the intelligent regulation of the air quantity control valve 3 is realized by adjusting.
Example two
Although the pressure difference can be quickly regulated by adopting the technical scheme, namely the pressure difference can be quickly regulated by adopting the single exhaust fan 2, the pressure of the external environment is not constant during actual regulation, and under the condition of higher precision requirement, the pressure difference can be caused to change by slight pressure change, so that the regulation precision is reduced; more serious, for example, at the moment of opening the door, the pressure difference is obviously changed, and along with the opening time of the door, the pressure difference is also quickly changed, in order to maintain the stability of the pressure difference, the speed of the exhaust fan 2 is generally required to be quickly changed, the pressure of the air supply pipeline and the air exhaust pipeline is quickly changed at the moment of changing the speed of the exhaust fan 2, so that the stability of the whole system is impacted, and meanwhile, the measurement accuracy of the air flow meter 5 is also reduced, and in the control process, the control of the exhaust fan 2, the air force and the air flow control valve 3 is relatively complex because the opening and closing of the air flow control valve 3 are not synchronous with the speed of the exhaust fan 2, and the adjustment accuracy of the whole system is also reduced under the condition that the pressure difference is greatly changed, for example, when the door is opened for a certain time, the pressure difference of clean rooms at two sides is relatively greatly changed, and the pressure difference adjustment of two or more clean rooms is required to be simultaneously and quickly carried out, and meanwhile, the control of the air flow control valve 3 is difficult to realize the high adjustment accuracy of the clean rooms.
Therefore, as shown in fig. 4, the preferred technical solution includes: for example, the pressure sensor comprises at least a clean zone a, a clean zone B, a clean zone C and a clean zone D, a constant pressure chamber 10 disposed above each clean zone and corresponding to the differential pressure gauge 4, wherein the constant pressure chamber 10 is a closed chamber, pressure stability of the constant pressure chamber 10 can be ensured to the greatest extent, thus, in cooperation with the arrangement of the differential pressure gauge 4, pressure differences can be measured accurately, pressure stabilizing chambers W1-W4 disposed above the clean zones a-D respectively, the arrangement of the pressure stabilizing chambers can make pressure inside the pressure stabilizing chambers equal to or substantially equal to pressure of the corresponding clean zones, for example, the pressure stabilizing chambers W1 and the pressure of the clean zone a are P1, the pressure stabilizing chambers W2 and the pressure of the clean zone B are P2, the pressure stabilizing chambers W3 and the pressure of the clean zone C are P3, the pressure stabilizing chambers W4 and the pressure of the clean zone D are P4, the pressure stabilizing chambers C1 disposed above the pressure stabilizing chambers W1 and the pressure stabilizing chambers W2, the pressure stabilizing chambers C2 disposed above the pressure stabilizing chambers W3 and the pressure stabilizing chambers W4 are greater than the pressure of the pressure stabilizing chambers W1 and the pressure stabilizing chambers W2, and the pressure meter C2 is disposed in the pressure stabilizing chambers W2 and the pressure meter is set up 15.
By means of the arrangement of the first pressure gauge and the second pressure gauge, the pressure of the inflating cavity C1 and the pressure of the inflating cavity C2 can be kept basically constant, and because the pressure in the clean room is usually caused by factors such as door opening or air leakage, continuous air supply is usually required, so that the air is supplied to the inflating cavities C1 and C2 to maintain the air pressure in the inflating cavities to be stable, the pressure stabilizing cavity C1 and the pressure stabilizing cavity C2 are respectively connected with the air blower 1 through the first valve 11 and the second valve 12, a lower differential pressure valve 17 is arranged between each clean area and the pressure stabilizing cavity P, an upper differential pressure valve 16 is arranged between each pressure stabilizing cavity P and the inflating cavity, a pressure gauge 14 is arranged in the inflating cavity, the control module opens the first valve 11 and the second valve 12 in a pulse mode to maintain the pressure of the inflating cavities C1 and the pressure stabilizing cavities, the pressure stabilizing cavities W1-W4 are respectively the preset pressures P1-P4 of the clean areas A-D, when the pressure of the clean areas and the pressure of the corresponding cavities exceeds the upper differential pressure threshold, and the lower differential pressure valve 17 is arranged to open when the pressure of the clean areas and the pressure stabilizing cavities exceeds the corresponding pressure threshold.
Through the above arrangement, when the internal pressure is slightly reduced, for example, when a door is opened rapidly or under the condition of slight air leakage, for example, if the pressure in a clean area A-D is reduced, for example, the pressure in the clean area A is reduced, when the clean area A (also can be B-D) is reduced, along with the continuous reduction of the pressure, the pressure difference between the pressure stabilizing cavity W1 and the clean area A exceeds the opening pressure difference of the lower differential pressure valve 17, further, the corresponding lower differential pressure valve 17 is arranged to be capable of sensing the pressure difference to exceed a preset value, the preset value can be smaller than a preset pressure value, namely, the pressure in the clean area is not reduced to the lower limit of the preset pressure value range, so that the precision of the clean area is adjusted as far as possible, therefore, the rotating speed of the exhaust fan 2 does not need to be adjusted at the lower limit of the preset pressure value range, so that the speed of the exhaust fan 2 can be kept at a stable speed more, the detecting precision of each component is improved, and the adjusting precision is improved, when the pressure change is larger, for example, when the door is opened for a long time, the opening time is not closed, the pressure of the pressure stabilizing cavity is difficult to meet the requirement of adjustment, or the pressure of the corresponding lower differential pressure valve is difficult to be satisfied, the preset value, the pressure difference exceeds the preset value, for example, the speed is not meeting the requirement of the preset value, the air supply speed is increased by the first speed, and the air supply speed is reduced by the fan 2, and the precision is adjusted to the speed of the air supply speed is reduced by the first speed, and the fan 2, and the speed is adjusted to the speed of the clean area 2.
In the invention, considering that the pressure of the clean area A, B, C, D is gradually increased, the pressure difference change rate of the clean areas A-D is sequentially reduced under the same sealing and door opening conditions, so that the pressure of the air charging cavity C1 is set to be larger than the pressure of the air charging cavity C2 in order to more quickly make up the pressure difference, the pressure difference of the clean area A and the clean area B can be more quickly regulated through the larger pressure, the air charging cavity C1 and the air charging cavity C2 are respectively inflated in a pulse mode when the air charging cavity is inflated, the pulse charging time corresponding to the air charging cavity C1 is longer in one pulse period, the pulse charging time corresponding to the air charging cavity C2 is shorter, the pressure balance of the air charging cavities C1 and C2 can be further realized, the pressure regulating precision is improved, the possibility that the pressure difference is excessively large to improve the rotating speed of the blower 1 and the exhaust fan 2 is further reduced, and the regulating precision is improved.
And in step S2, it includes: the monitoring module acquires an actual pressure value of each clean area, judges whether the actual pressure value is lower than the lower limit of a preset pressure value range, calculates the gas volume required by the clean room from the actual pressure value to the lower limit of the preset pressure value range based on a pressure relation function, judges whether the gas in a corresponding pressure stabilizing cavity is larger than the required gas volume, does not adjust the wind speed when the gas in the pressure stabilizing cavity is larger than the required gas volume, and inflates the inflation cavity by the blower, reduces the opening of the air volume control valve according to the required gas volume, the difference between the pressure stabilizing cavity and the required volume and the preset adjustment time when the gas in the pressure stabilizing cavity is not larger than the required gas volume, and executes step S3 when the actual pressure value is not lower than the lower limit of the preset pressure value range; further, when the gas in the pressure stabilizing cavity is not larger than the required gas volume, the opening of the air quantity control valve is reduced according to the required gas volume, the difference between the pressure stabilizing cavity and the required volume and the preset adjusting time, and meanwhile, when the pressure of the clean room is close to a preset value, the rotating speed of the exhaust fan is reduced again, and the pressure adjustment of the clean room is realized through the pressure stabilizing cavity.
According to the second preferred embodiment of the invention, accurate determination of the pressure difference of the clean room can be realized by matching with the constant pressure cavity, and the pressure regulation can be realized by matching with the upper and lower pressure difference valves, the pressure regulation cavity, the air charging cavity, the first valve, the second valve and the control module, so that the clean room can be regulated in pressure in real time, the pressure difference is prevented from being continuously expanded, meanwhile, the pressure of the clean room is maintained by supplementing air to the clean room through the pressure regulation gas in the pressure regulation cavity in time, the blower can be always maintained at a constant speed to a large extent through the steps, the rotating speed of the exhaust fan is reduced, the regulation precision is improved, the pressure maintenance can be simultaneously realized through the matching of the pressure regulation cavity and the blower even when the pressure of the pressure regulation cavity is insufficient to compensate the pressure in the clean room, the compensation speed is improved, and the wind speed of the exhaust fan can be reduced when the pressure is close to the preset pressure in the clean area, and the pressure compensation is performed through the pressure regulation cavity again, so that the pressure difference precision of the clean area is improved.
Those skilled in the art will appreciate that implementing all or part of the above-described methods may be accomplished by way of computer programs, which may be stored on a non-transitory computer readable storage medium, and which, when executed, may comprise the steps of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the various embodiments provided herein may include non-volatile and/or volatile memory. The nonvolatile memory can include Read Only Memory (ROM), programmable ROM (PROM), electrically Programmable ROM (EPROM), electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double Data Rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous Link DRAM (SLDRAM), memory bus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), among others.
The technical features of the above embodiments may be arbitrarily combined, and for brevity, all of the possible combinations of the technical features of the above embodiments are not described, however, they should be considered as the scope of the description of the present specification as long as there is no contradiction between the combinations of the technical features.
The foregoing examples have been presented to illustrate only a few embodiments of the invention and are described in more detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.

Claims (9)

1. Accurate control system of clean district pressure differential in pharmaceutical production workshop, characterized by, include:
The air feeder is connected with each clean zone through an air supply pipeline and is used for feeding gas into each clean zone;
the exhaust fans are respectively connected with each clean area through exhaust pipelines and are used for exhausting gas in the clean areas;
the air return quantity detection device is used for detecting the air return quantity of the clean room;
the air quantity control valve is arranged in each exhaust pipeline, and the air quantity passing through the exhaust pipeline is improved by increasing the opening of the air quantity control valve;
the differential pressure gauge is arranged in each clean zone and is used for detecting the absolute differential pressure between the clean zone and the external environment;
the air flow meter is arranged on a door between the air exhaust pipeline and the adjacent clean area, and is used for respectively acquiring and recording a first air flow rate passing through the air exhaust pipeline in unit time and a second air flow rate passing through the door when the door is opened when the air volume control valve is positioned at different openings;
the angle sensor is arranged on the door and is used for detecting the opening angle of the door;
the monitoring module is connected with the exhaust fan, the differential pressure gauge, the gas flowmeter and the angle sensor, a preset pressure value range and a preset adjusting time of each clean area are stored in the monitoring module, when the monitoring module detects that the actual pressure value of the clean area is out of the preset pressure value range, the monitoring module generates a corresponding control instruction based on the magnitude of a deviation value and the preset adjusting time, when the door is opened, the monitoring module adjusts the first gas flow rate based on the second gas flow rate so as to reduce fluctuation of pressure in the clean area, and when the monitoring module determines that the door is opened through a first formula, the first formula is that: Wherein Q is 2 For the second gas flow rate, h is the height of the door, w is the width of the door, θ is the opening angle of the door, and s is the sectional area of the exhaust duct;
and the control module receives the control instruction, and adjusts the rotating speed of the exhaust fan and the opening of the air quantity control valve according to the control instruction so as to adjust the pressure in the clean area.
2. The method for precisely controlling the pressure difference of the clean zone of the pharmaceutical production workshop according to claim 1, comprising at least a clean zone A, a clean zone B, a clean zone C and a clean zone D, wherein constant pressure chambers are arranged above each clean zone and are corresponding to pressure difference meters, pressure stabilizing chambers W1-W4 are respectively arranged above the clean zones A-D, an inflation chamber C1 is arranged above the pressure stabilizing chambers W1 and W2, an inflation chamber C2 is arranged on the pressure stabilizing chambers W3 and W4, a first pressure meter is arranged in the inflation chamber C1, a second pressure meter is arranged in the inflation chamber C2, the inflation chamber C1 and the inflation chamber C2 are respectively connected with a blower through a first valve and a second valve, a lower pressure difference valve is arranged between each clean zone and each inflation chamber, pressure meters are respectively arranged in the inflation chambers, the control module is based on the pressure values of the first pressure meters and the second pressure meters, when the pressure stabilizing chambers W1 and the pressure stabilizing chambers C2 are respectively configured to be the pressure difference values of the pressure stabilizing chambers P-C1 and the pressure stabilizing chambers P-P, and the pressure difference values of the pressure stabilizing chambers P-C1 are respectively opened when the pressure stabilizing chambers C1 and the pressure values of the pressure stabilizing chambers are respectively set to be equal to the pressure difference values of the pressure stabilizing chambers P-C1.
3. The method for precisely controlling the pressure difference of the clean area of the medicine production workshop is realized based on the precisely controlling system for the pressure difference of the clean area of the medicine production workshop, and is characterized by comprising the following steps:
step S1, obtainingTaking a pressure relation function V 0 =f(P 1 -P 2 ) Wherein V is 0 For cleaning the room from the first pressure value P 1 Reaching the second pressure value P 2 The volume of gas required;
step S2, the monitoring module acquires an actual pressure value of a clean zone, judges whether the actual pressure value is lower than the lower limit of the preset pressure value range, if yes, the monitoring module calculates the gas volume required by the clean room from the actual pressure value to the lower limit of the preset pressure value range based on a pressure relation function, and reduces the opening of the air volume control valve according to the required gas volume and the preset adjusting time, and if not, the step S3 is executed;
and S3, the monitoring module judges whether the actual pressure value is higher than the upper limit of the preset pressure value range, and if so, the monitoring module calculates the volume of gas required by the clean room from the actual pressure value to the upper limit of the preset pressure value range based on a pressure relation function, and increases the opening of the air quantity control valve and the rotating speed of the exhaust fan according to the required volume of gas and the preset adjusting time.
4. The method for precisely controlling the pressure difference in the clean room of the pharmaceutical production plant according to claim 3, wherein the step S2 comprises: the monitoring module obtains the actual pressure value of each clean zone, judges whether the actual pressure value is lower than the lower limit of the preset pressure value range, when the actual pressure value is lower than the lower limit of the preset pressure value range, the monitoring module calculates the gas volume required by the clean chamber from the actual pressure value to the lower limit of the preset pressure value range based on a pressure relation function, meanwhile judges whether the gas in the corresponding pressure stabilizing cavity is greater than the required gas volume, when the gas in the pressure stabilizing cavity is greater than the required gas volume, the blower inflates the inflation cavity, when the gas in the pressure stabilizing cavity is not greater than the required gas volume, the opening of the air volume control valve is reduced according to the required gas volume, the difference between the pressure stabilizing cavity and the required volume and the preset regulating time, and when the actual pressure value is not lower than the lower limit of the preset pressure value range, the step S3 is executed.
5. The method according to claim 3, wherein in the step S1, the pressure relation function is determined according to the space size of the clean room, the gas temperature and the amount of the gas material.
6. The method according to claim 3, wherein in the step S2, a minimum opening is preset in the air volume control valve, and the minimum opening is 15% of the total opening of the air volume control valve.
7. The method according to claim 6, wherein in the step S3, after the monitoring module obtains the gas volume required by the clean room from the actual pressure value to reach the upper limit of the preset pressure value range, the monitoring module determines whether the required gas volume satisfies a second formula, if yes, the monitoring module adjusts the opening of the air volume control valve to the upper limit, and increases the rotational speed of the exhaust fan according to the required gas volume, if no, the monitoring module only increases the opening of the air volume control valve, the second formula is: v (V) 0 |>V 2 +V 3 -V 1 Wherein V is 1 、V 2 、V 3 The current blower rotating speed, the current exhaust fan rotating speed and the current air quantity control valve are respectively in the condition of maximum opening, and in the preset adjusting time, the air supply volume of the blower, the air exhaust volume of the exhaust fan and the air return volume of the clean room are respectively.
8. The method according to claim 6, wherein in the step S2, the monitoring module reduces the opening of the air volume control valve according to the required gas volume and the preset adjustment time, the method comprising the steps of:
step S21, the monitoring module calculates the first gas flow rate Q required by the exhaust pipeline in unit time in the preset adjusting time through a third formula 1 The third formula is:wherein Q is 0 T is the preset adjusting time for the current first gas flow rate in the exhaust pipeline;
step S22, the monitoring module adjusts the opening degree of the air quantity control valve based on the relation between the first air flow rate and the opening degree of the air quantity control valve.
9. The method for precisely controlling the pressure difference in the clean room of the pharmaceutical production plant according to claim 4, wherein the step S2 further comprises: when the gas in the pressure stabilizing cavity is not larger than the required gas volume, the pressure stabilizing cavity and the required volume are adjusted according to the required gas volume, the difference between the pressure stabilizing cavity and the required volume and the pre-treatment
Setting the adjusting time to reduce the opening of the air quantity control valve, and simultaneously when the pressure of the clean room is close to a preset value,
And the rotating speed of the exhaust fan is reduced again, and the pressure regulation of the clean room is realized through the pressure stabilizing cavity.
CN202310129789.XA 2023-02-17 2023-02-17 System and method for precisely controlling pressure difference in clean area of medicine production workshop Pending CN117287800A (en)

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CN202310129789.XA CN117287800A (en) 2023-02-17 2023-02-17 System and method for precisely controlling pressure difference in clean area of medicine production workshop

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