CN117224781A - Drug delivery device capable of setting and recalling dose - Google Patents
Drug delivery device capable of setting and recalling dose Download PDFInfo
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- CN117224781A CN117224781A CN202311166088.XA CN202311166088A CN117224781A CN 117224781 A CN117224781 A CN 117224781A CN 202311166088 A CN202311166088 A CN 202311166088A CN 117224781 A CN117224781 A CN 117224781A
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- push rod
- differential
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 8
- 238000002347 injection Methods 0.000 claims abstract description 62
- 239000007924 injection Substances 0.000 claims abstract description 62
- 239000003814 drug Substances 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 17
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 10
- 102000004877 Insulin Human genes 0.000 description 5
- 108090001061 Insulin Proteins 0.000 description 5
- 229940125396 insulin Drugs 0.000 description 5
- 238000010586 diagram Methods 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011295 pitch Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The drug delivery device capable of setting and recalling the dose comprises a cartridge frame, wherein the rear end of the cartridge frame is connected with a shell, and a push rod is arranged in the shell and used for delivering the drug after moving according to the set dose during injection; the rotor is in threaded connection with the push rod and is used for rotationally driving the push rod to axially move forwards during injection; the front end of the rotating shaft is connected in the rear end of the rotor, is used for driving the rotor to rotate during injection, can axially move relative to the rotor, and can be matched with the push rod to control final dose setting during the axial movement; the differential nut is arranged at the outer side of the rear end of the rotating shaft and is used for differential adjustment and driving the rotating shaft to axially move; the differential screw is fixed in the shell, is arranged between the differential nut and the dose setting rotary drum and is in threaded connection with the differential nut and the dose setting rotary drum; the dose setting rotary drum can be meshed with the bushing and drive the bushing to rotate during injection, and is used for driving the differential nut to synchronously rotate; and the bushing is connected to the inner side of the rear end of the rotating shaft and used for driving the rotating shaft to rotate during injection.
Description
Technical Field
The invention belongs to the technical field of drug delivery devices, and particularly relates to a drug delivery device capable of setting and recalling a dose.
Background
With the development of insulin injection pen technology, the current requirements for insulin injection pens already comprise (1) that small dose injections can be performed for multiple times, and the maximum single injection dose (60 IU) can be generally achieved for not less than 5 times; (2) The single injection dosage is convenient to adjust, the adjusting range is 0-60IU, and the adjusting precision is high (can reach 1 IU); (3) When the dosage is regulated, the graduations can be visually observed, and the injection pen can also make a sound so as to be convenient for patients with poor eyesight and even blindness to operate by themselves; (4) During injection, the operation is simple, and the injection pen can make a sound in the injection process to indicate that the injection process is in progress.
The prior art CN 103170038A discloses an insulin injection pen, which comprises a pen cap, a needle head, an injection tube, an injection sleeve, a positioning fixture block, a screw rod, a nut tube, a fixed tube, a coil tube and a button, wherein the injection tube is internally provided with a piston and is preloaded with a medicament; the nut pipe is arranged between the pressure head and the positioning clamping block; the rotary spring is sleeved on the coil, one end of the rotary spring is fixed with the inner side of the rotary handle, and the other end of the rotary spring is fixed with the positioning clamping block. According to the invention, repeated adjustment of the positioning clamping block, the rotary spring and the clutch spring can realize repeated use and precise metering control of insulin injection. Although the insulin injection pen can accurately control the dosage, the regulation and control structure is complex, the callback dosage can not be realized, and the sub-dosage injection can not be prevented.
Disclosure of Invention
Aiming at the problems in the background technical introduction, the invention aims to provide a drug delivery device capable of setting and recalling the dose, which has simple and reasonable structure and can prevent sub-dose injection.
The technical scheme adopted by the invention is as follows:
the dosing device capable of setting and recalling doses comprises a refill holder, wherein a detachable pen cap is arranged at the front end of the refill holder, a clamping bottle is arranged in the refill holder, a shell is connected with the rear end of the refill holder, and a shell is arranged in the shell
The push rod is used for delivering the medicine after moving according to the set dose during injection;
the rotor is in threaded connection with the push rod, is used for driving the push rod to move forwards axially in a rotating way during injection, and can be matched with the shell for injection sounding;
the front end of the rotating shaft is connected in the rear end of the rotor, is used for driving the rotor to rotate during injection, can axially move relative to the rotor, and can be matched with the push rod to control final dose setting during the axial movement;
the differential nut is arranged at the outer side of the rear end of the rotating shaft and is used for differential adjustment and driving the rotating shaft to axially move;
the differential screw rod is fixed in the shell, is arranged between the differential nut and the dose setting rotary drum, is in threaded connection with the differential nut and the dose setting rotary drum for differential adjustment, is in rotational connection with the rotor and axially limits the rotor;
the dose setting rotary drum is used for driving the bush to axially move and sounding when setting the dose and matching with the dose setting, can be meshed with the bush and driving the bush to rotate when injecting, and is also used for driving the differential nut to synchronously rotate;
the bushing is connected to the inner side of the rear end of the rotating shaft and used for driving the rotating shaft to rotate during injection;
an injection button capable of applying force to drive the dose setting drum to rotate anticlockwise and driving the lining to rotate synchronously after being meshed with the dose setting drum is arranged in the rear end of the dose setting drum.
Further, the outer surface of the rotor is provided with convex unidirectional ratchets, the inner ring of the shell is uniformly provided with notches, and the unidirectional ratchets and the notches are matched for injection sounding in the rotating process.
Furthermore, the dose setting barrel and the lining are uniformly provided with engaging teeth in the axial direction, and when the dose setting barrel rotates, the engaging teeth on the dose setting barrel and the engaging teeth on the lining are in sliding fit with dose setting sounding.
Further, the rotor and the rotating shaft, the rotating shaft and the bushing, and the differential nut and the dose setting drum are all axial slots.
Further, the rotating shaft is connected with the differential nut, and the rotor is connected with the differential screw rod through a circumferential ring.
Further, the rear end of the push rod is provided with a flange, the inside of the front end of the rotating shaft is provided with a step, and the flange and the step can be in contact with each other to limit and control final dose setting.
Further, the push rod is a screw rod.
Further, a push plate matched with the piston of the clip-on bottle is arranged at the front end of the push rod.
Further, the push rod and the push plate are of an integrated structure, and a radial through groove is formed in the front end of the push rod and the push plate, so that deformation assembly is facilitated during assembly.
Further, a spring for resetting is arranged between the injection button and the bushing.
Compared with the prior art, the invention has the remarkable advantages that:
1. the rotating shaft can be matched with the push rod to control final dose setting in the axial movement process, so that sub-dose injection is prevented;
2. the dose setting and callback process and the injection process are realized through the matching of the components among the dose setting rotary drum, the differential screw, the differential nut, the rotating shaft, the bushing and the rotor, and the structure is simple and reasonable;
3. the rotor and the shell cooperate with the injection sounding to remind a user of injecting the dosage;
4. the cooperation between the dose setting drum and the sleeve sounds the user of the dose setting.
Drawings
Fig. 1 is a schematic view of the external structure of the present invention.
Fig. 2 is a schematic diagram of the explosive structure of the present invention.
Fig. 3 is a schematic cross-sectional view of the present invention.
Fig. 4 is a schematic structural view of the dose setting of the present invention.
Fig. 5 is a schematic structural view of the injection process of the present invention.
Fig. 6 is a schematic diagram of the structure of the final dose setting control of the present invention.
Fig. 7 is a schematic view of the structure of the present invention after use.
Fig. 8 is a schematic structural view of the rotor and the housing of the present invention with sound production.
Fig. 9 is a schematic view of the axial slot connection of the differential nut and the dose setting drum of the present invention.
Fig. 10 is a schematic view of a second construction of the push rod of the present invention.
In the figure: 1-a pen cap; 2-a pen refill holder; 3-card bottle; 4-rotor; 41-one-way ratchet teeth; 42-ring grooves; 5-pushing plate; 6-a housing; 61-notch; 7-a differential screw; 71-ring ribs; 8-pushing rod; 81-flanges; 82-through grooves; 9-rotating shaft; 91-steps; 10-differential nuts; 101-ribs; 11-a dose setting drum; 111-elongated slots; 12-a bushing; 13-an injection button; 14-a spring; 15-meshing teeth.
Detailed Description
The invention will be further illustrated with reference to the following specific examples, without limiting the invention to these specific embodiments. It will be appreciated by those skilled in the art that the invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present invention, unless otherwise specified, the meaning of "a plurality" is two or more, unless otherwise clearly defined.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present invention, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.
Example 1
Referring to fig. 1-9, this embodiment provides a drug delivery device capable of setting and recalling a dose, comprising a pen core frame 2, wherein a detachable pen cap 1 is arranged at the front end of the pen core frame 2, a clip bottle 3 is arranged in the pen core frame 2, a housing 6 is connected with the rear end of the pen core frame 2, and a housing 6 is arranged therein
The push rod 8 is a screw structure and is used for delivering medicines after moving according to the set dosage during injection; the front end of the push rod 8 is provided with a push plate 5 which is used for being matched with the piston of the clip-on bottle 3;
the rotor 4 is in threaded connection with the push rod 8, is used for driving the push rod 8 to move forward axially in a rotating way during injection, and can be matched with the shell 6 for injection sounding;
the front end of the rotating shaft 9 is connected to the rear end of the rotor 4, and is used for driving the rotor 4 to rotate during injection, and can axially move relative to the rotor 4, and can control the final dose setting in cooperation with the push rod 8 during the axial movement;
the differential nut 10 is arranged outside the rear end of the rotating shaft 9, and is used for differential adjustment and driving the rotating shaft 9 to axially move;
the differential screw rod 7 is fixed in the shell 6 and arranged between the differential nut 10 and the dose setting rotary drum 11, is in threaded connection with the differential nut 10 and the dose setting rotary drum 11 for differential adjustment, is in rotational connection with the rotor 4 and axially limits the rotor 4 so that the rotor cannot axially move and can only radially rotate; the pitches of the internal and external threads of the differential screw 7 are different so as to realize differential adjustment;
the dose setting drum 11 is used for driving the liner 12 to axially move and sounding in cooperation with the liner 12 when setting a dose, can be meshed with the liner 12 and driving the liner 12 to rotate when injecting, and is also used for driving the differential nut 10 to synchronously rotate;
a bushing 12 connected to the inner side of the rear end of the rotation shaft 9 for driving the rotation shaft 9 to rotate during injection;
an injection button 13 capable of applying force to drive the dose setting drum 11 to rotate anticlockwise and driving the bush 12 to rotate synchronously after being meshed with the dose setting drum 11 is arranged in the rear end of the dose setting drum 11, and a spring 14 for resetting is arranged between the injection button 13 and the bush 12.
In this embodiment, the outer surface of the rotor 4 is provided with protruding unidirectional ratchets 41, the casing 6 is internally and annularly provided with uniformly distributed notches 61, and the unidirectional ratchets 41 and the notches 61 are matched for injection sounding in the rotation process. The unidirectional ratchet 41 restricts the rotation direction of the rotor 4 to counterclockwise rotation only. Each unit of rotation can be set as desired and a reminder can be sounded to remind the user to inject a dose. Specifically, 24 notches 61 are formed in the casing 6, unidirectional ratchets 41 are symmetrically formed on the outer surface of the rotor 4, and the rotor 4 sounds once when rotating for 15 degrees.
In this embodiment, the dose setting barrel 11 and the sleeve 12 are uniformly provided with engaging teeth 15 in the axial direction, and when the dose setting barrel 11 rotates, the engaging teeth 15 on the dose setting barrel 11 and the engaging teeth 15 on the sleeve 12 are in sliding fit with each other to set a dose. The engaging teeth 15 on the dose setting barrel 11 axially abut against the engaging teeth 15 on the bush 12, and when the dose setting barrel 11 rotates, vibration and sound occur due to direct collision of tooth surfaces with tooth surfaces.
In this embodiment, the rotor 4 and the rotating shaft 9, the rotating shaft 9 and the bushing 12, and the differential nut 10 and the dose setting drum 11 are all axially grooved to realize synchronous rotation. Taking the connection of the axial grooves of the differential nut 10 and the dose setting drum 11 as an example, ribs 101 or rib platforms protruding are axially arranged on the outer surface of the differential nut 10, a strip-shaped groove 111 is axially arranged on the inner wall of the dose setting drum 11, and the ribs 101 are connected with the strip-shaped groove 111 in a matching axial groove.
In this embodiment, the rotating shaft 9 and the differential nut 10, and the rotor 4 and the differential screw 7 are all circumferential rings. Taking the rotor 4 and the differential screw 7 as examples, the outer surface of the rotor 4 is provided with a ring groove 42, the inner surface of the differential screw 7 is provided with a convex ring rib 71 or a ring table, and the ring groove 42 is connected with the ring rib 71 in a circumferential ring in a matching manner. The connection of the rotor 4 with the circumferential ring of the differential screw 7 is to limit the axial movement of the rotor 4, and the rotor 4 can rotate relative to the differential screw 7. The rotating shaft 9 is connected with the circumferential ring of the differential nut 10, the differential nut 10 drives the rotating shaft 9 to axially move, and the rotating shaft 9 and the differential nut 10 can relatively rotate.
In this embodiment, a flange 81 is provided at the rear end of the push rod 8, a step 91 is provided inside the front end of the rotation shaft 9, and the flange 81 and the step 91 can contact to limit and control the final dose setting.
In the present invention, when dose setting is performed, the dose setting drum 11 is rotated clockwise, and the differential nut 10 is rotated clockwise in synchronization with the dose setting drum 11 due to the axial groove connection provided between the dose setting drum 11 and the differential nut 10. The differential nut 10 is screwed with the differential screw 7 which is fixed in both axial and circumferential directions and is sleeved outside thereof, and the differential nut 10 is rotated clockwise along the screw track of the differential screw 7 and axially displaced proximally during the above-described rotation. The differential nut 10 is connected with the rotating shaft 9 through a circumferential ring, so that the rotating shaft 9 can be driven to move towards the proximal end in the axial direction. The rotor 4 and the rotation shaft 9, the rotation shaft 9 and the sleeve 12 are all arranged to be connected in axial grooves, wherein the rotor 4 is always limited in axial direction and is arranged to rotate only in one way anticlockwise direction, so that when a dose is set, the rotor 4 does not rotate and the rotation shaft 9 is limited to prevent the rotation of the rotor, the rotation shaft 9 further limits the sleeve 12 to prevent the rotation of the sleeve 12, and the sleeve 12 can only move along with the dose setting sleeve 11 towards the proximal axial direction due to the abutting relation between the proximal end of the dose setting sleeve 11 and the sleeve 12, and during the period, the abutting part of the dose setting sleeve 11 and the sleeve 12 generates vibration and sound due to the fact that one tooth surface is scratched by the other tooth surface, so that the dose setting sounding is realized.
When the invention is used for callback, the callback process is opposite to the dose setting process, the dose setting rotary drum 11 is rotated anticlockwise, the differential nut 10 can synchronously rotate anticlockwise along with the dose setting rotary drum 11, and the differential nut rotates anticlockwise along the threaded track of the differential screw 7 and generates axial displacement to the far end so as to realize callback. During the callback process, the rotating shaft 9 moves along with the differential nut 10 in the distal axial direction, the lining 12 moves along with the dose setting sleeve 11 in the distal axial direction under the limit of the injection button 13 and the spring 14, and during the period, the abutting part of the dose setting sleeve 11 and the lining 12 generates vibration and sound due to the fact that one tooth surface is scratched by the other tooth surface, so that the dose callback sounding is realized.
When the injection is carried out, the injection button 13 is pressed, force is applied to the dose setting drum 11, the dose setting drum 11 is meshed with the tooth surface of the lining 12, the dose setting drum 11 rotates anticlockwise distally, the differential nut 10 connected with the axial groove of the dose setting drum rotates anticlockwise synchronously, and the lining 12 also rotates anticlockwise synchronously. The bush 12 drives the rotating shaft 9 to rotate anticlockwise, (the rotating shaft 9 drives the rotor 4 to rotate anticlockwise, and the rotor 4 drives the push rod 8 to move distally linearly, so that injection is realized, a prompt tone can be given out by each unit of rotation of the rotor 4. Because of the circumferential ring connection between the differential nut 10 and the rotating shaft 9, the differential nut 10 can drive the rotating shaft 9 to move distally in the injection process.
When the invention carries out final dose setting control, the dose setting rotary drum 11 is rotated clockwise, the differential nut 10 which rotates clockwise synchronously drives the rotating shaft 9 to move towards the proximal end axially, and when the step 91 arranged in the rotating shaft 9 abuts against the flange 8 of the push rod 8, the rotating shaft 9 cannot move towards the proximal end continuously. Since the rotation shaft 9 is connected to the differential nut 10 by a circumferential ring, the rotation shaft 9 cannot move proximally, the differential nut 10 cannot move proximally, and the axial groove between the differential nut 10 and the dose setting sleeve 11 is connected, so that the dose setting sleeve 11 cannot rotate clockwise. At this point, if the sub-dose setting has failed to reach the predetermined dose by continuing to rotate the dose setting sleeve 11, the sub-dose setting is unsuccessful and explicitly alerts the pen user, thereby enabling control of the final dose, preventing sub-dose injection from occurring.
The rotating shaft 9 can be matched with the push rod 8 to control final dose setting in the axial movement process, so that sub-dose injection is prevented; the dose setting and callback process and the injection process are realized through the matching of the components among the dose setting rotary drum 11, the differential screw 7, the differential nut 10, the rotating shaft 9, the bushing 12 and the rotor 4, and the structure is simple and reasonable; the rotor 4 and the shell 6 cooperate with injection sounding to remind a user of injecting the dosage; the cooperation between the dose setting drum 11 and the sleeve 12 sounds the user of the dose setting.
Example two
Referring to fig. 10, the present embodiment is different from the first embodiment in that: the push rod 8 and the push plate 5 are of an integral structure, and a radial through groove 82 is formed in the front end of the push rod, so that deformation assembly during assembly is facilitated. Meanwhile, the number of parts is reduced, and the assembly process is simplified.
The rest of the structure and function are as described with reference to the first embodiment.
Claims (10)
1. Drug delivery device capable of setting and recalling doses, comprising a refill holder (2), wherein the front end of the refill holder (2) is provided with a detachable pen cap (1), a clamping bottle (3) is arranged in the refill holder (2), and the rear end of the refill holder (2) is connected with a shell (6), and is characterized in that: the shell (6) is internally provided with
A push rod (8) for delivering the drug after moving according to the set dose during injection;
the rotor (4) is in threaded connection with the push rod (8), is used for driving the push rod (8) to axially move forwards in a rotating way during injection, and can be matched with the shell (6) for injection sounding;
the front end of the rotating shaft (9) is connected into the rear end of the rotor (4) and is used for driving the rotor (4) to rotate during injection and can axially move relative to the rotor (4), and the rotating shaft can be matched with the push rod (8) to control final dose setting during the axial movement;
the differential nut (10) is arranged at the outer side of the rear end of the rotating shaft (9) and is used for differential adjustment and driving the rotating shaft (9) to axially move;
the differential screw (7) is fixed in the shell (6) and arranged between the differential nut (10) and the dose setting rotary drum (11), is in threaded connection with the differential nut (10) and the dose setting rotary drum (10) for differential adjustment, is in rotational connection with the rotor (4) and axially limits the rotor (4);
the dose setting rotary drum (11) is used for driving the bush (12) to axially move and sounding in cooperation with the bush (12) during dose setting, can be meshed with the bush (12) and drives the bush (12) to rotate during injection, and is also used for driving the differential nut (10) to synchronously rotate;
the bushing (12) is connected to the inner side of the rear end of the rotating shaft (9) and is used for driving the rotating shaft (9) to rotate during injection;
an injection button (13) which can apply force to drive the dose setting drum (11) to rotate anticlockwise and drive the bush (12) to rotate synchronously after being meshed with the dose setting drum (11) is arranged in the rear end of the dose setting drum (11).
2. The settable and callbacks dosing device according to claim 1, wherein: the outer surface of the rotor (4) is provided with convex unidirectional ratchets (41), notches (61) are uniformly distributed in the inner ring of the shell (6), and the unidirectional ratchets (41) and the notches (61) are matched for injection sounding in the rotating process.
3. The settable and callbacks dosing device according to claim 1, wherein: the dose setting barrel (11) and the lining (12) are axially and uniformly provided with meshing teeth (15), and when the dose setting barrel (11) rotates, the meshing teeth (15) on the dose setting barrel (11) and the meshing teeth (15) on the lining (12) are in sliding fit for setting and sounding of the dose.
4. The settable and callbacks dosing device according to claim 1, wherein: the rotor (4) is connected with the rotating shaft (9), the rotating shaft (9) is connected with the bushing (12), and the differential nut (10) is connected with the dose setting drum (11) through axial grooves.
5. The settable and callbacks dosing device according to claim 1, wherein: the rotating shaft (9) is connected with the differential nut (10), and the rotor (4) is connected with the differential screw (7) through circumferential rings.
6. The settable and callbacks dosing device according to claim 1, wherein: the rear end of the push rod (8) is provided with a flange (81), the inside of the front end of the rotating shaft (9) is provided with a step (91), and the flange (81) and the step (91) can be in contact with limit to control final dose setting.
7. The settable and callbacks dosing device according to any of the claims 1 to 6, wherein: the push rod (8) is a screw rod.
8. The settable and callbacks dosing device according to claim 7, wherein: the front end of the push rod (8) is provided with a push plate (5) which is matched with the piston of the clip-on bottle (3).
9. The settable and callbacks dosing device according to claim 8, wherein: the push rod (8) and the push plate (5) are of an integrated structure, and a radial through groove (82) is formed in the front end of the push rod.
10. The settable and callbacks dosing device according to claim 1, wherein: a spring (14) for resetting is arranged between the injection button (13) and the bushing (12).
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