CN117204917B - Bolt taking device - Google Patents
Bolt taking device Download PDFInfo
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- CN117204917B CN117204917B CN202311473810.4A CN202311473810A CN117204917B CN 117204917 B CN117204917 B CN 117204917B CN 202311473810 A CN202311473810 A CN 202311473810A CN 117204917 B CN117204917 B CN 117204917B
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- broken bolt
- capturing net
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Abstract
The invention relates to a thrombus taking device, comprising: the thrombus capturing net comprises a distal capturing net and a proximal capturing net connected with one end of the distal capturing net; pushing the guide wire, wherein one end of the guide wire is connected with the proximal capturing net; the suction catheter is sleeved at the other end of the pushing guide wire; the broken bolt sleeve is sleeved at the other end of the pushing guide wire and is positioned between the suction catheter and the pushing guide wire; the broken bolt spiral wire is sleeved on the pushing guide wire, and one end of the broken bolt spiral wire is connected with one end of the broken bolt sleeve close to the proximal capturing net; the broken bolt sleeve can drive the broken bolt spiral wire to move along the length direction of the pushing guide wire; and/or the thrombolytic sleeve can drive the thrombolytic spiral wire to rotate around the pushing guide wire. The thrombus is fully cut through the broken thrombus spiral wire, meanwhile, the thrombus is doubly captured by the proximal capturing net and the distal capturing net, and finally the thrombus is taken out by combining the suction catheter, so that the risk of thrombus escape is avoided.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a thrombus taking device.
Background
Cerebral apoplexy is also called cerebral apoplexy, is a local brain dysfunction caused by acute cerebrovascular diseases, has clinical symptoms lasting more than 24 hours, and has the characteristics of high morbidity, high mortality, high disability rate and high recurrence rate. The acute cerebrovascular disease, cerebral stroke, is commonly seen in people over 50 years old. The incidence rate of cerebral apoplexy in China rises year by year and becomes the first lethal reason in China.
At present, the main treatment means for ischemic cerebral apoplexy is thrombolysis by adopting a medicine and an interventional instrument for thrombolysis. In 4-5 hours of onset, adopting medicine thrombolysis is the preferred scheme for treating acute ischemic cerebral apoplexy, but because the time window is too short, few cerebral apoplexy patients meet the treatment conditions of medicine thrombolysis. Meanwhile, the thrombolysis medicine also has the risks of low vascular recanalization rate, high bleeding complication occurrence rate and the like. Then, the interventional instrument thrombus extraction is gradually developed, and the interventional instrument thrombus extraction has good application prospect in clinic. The therapeutic mode applicability of the interventional instrument for thrombus removal is wider, and the occluded blood vessel can be quickly recanalized, so that the incidence rate of drug complications is reduced, and the postoperative condition of a patient is improved.
Clinically, mechanical thrombolysis has the advantage of more rapid vascular recanalization, but is susceptible to factors such as thrombus size, thrombus properties, occlusion location, etc. The current thrombus taking device is weak in thrombus taking capability of high-load large thrombus and hard heart-source thrombus, as shown in fig. 1, one end of a left side support penetrates through a right side support, the left side support can move left and right, the current thrombus taking device can only be embedded through the cooperation thrombus of the left side support and the right side support, but the large thrombus or hard thrombus cannot be cut into small thrombus, the three-stage recanalization rate is low, the vascular intima is easily damaged by repeated thrombus taking, and the bleeding risk is increased. In addition, the existing thrombus removing device can not completely remove thrombus, high-load thrombus and cardiac thrombus with harder texture are easy to clamp at the suction catheter opening, even clamp at the BGC catheter opening or fall off from the catheter opening, and the risk that small thrombus which falls off partially escapes to a medium-small blood vessel at the far end is often accompanied. Meanwhile, multiple thrombus taking increases vascular recanalization time, causes more brain cell necrosis and causes irreparable brain injury.
Disclosure of Invention
The invention provides a thrombus taking device, which solves the technical problems that the existing thrombus taking device can only be embedded with thrombus, the thrombus can not be completely removed, high-load-quantity thrombus and cardiac thrombus with harder texture are easy to be blocked at a suction catheter port, even blocked at a BGC catheter port or fall off from the catheter port, and small thrombus which is often accompanied by partial fall off escapes to a medium-small blood vessel at a far end.
The invention discloses a thrombus taking device which comprises a thrombus catching net, a pushing guide wire, a suction catheter, a thrombus breaking sleeve and a thrombus breaking spiral wire. The thrombus capturing net comprises a distal capturing net and a proximal capturing net connected with one end of the distal capturing net; one end of the pushing guide wire is connected with the proximal capturing net; the suction guide wire is sleeved at the other end of the pushing guide wire; the broken bolt sleeve is sleeved at the other end of the pushing guide wire and is positioned between the suction catheter and the pushing guide wire; the broken bolt spiral wire is sleeved on the pushing guide wire, and one end of the broken bolt spiral wire is connected with one end of the broken bolt sleeve close to the proximal capturing net; the broken bolt sleeve can drive the broken bolt spiral wire to move along the length direction of the pushing guide wire; and/or the thrombolytic sleeve can drive the thrombolytic spiral wire to rotate around the pushing guide wire.
Further, the broken bolt spiral wire comprises a reducing spring wire, and the outer diameter of one end of the broken bolt spiral wire is smaller than that of the other end of the broken bolt spiral wire.
Further, one end of the broken bolt spiral wire with the small outer diameter is connected with one end of the broken bolt sleeve close to the proximal capturing net; or one end of the broken bolt spiral wire with the large outer diameter is connected with one end of the broken bolt sleeve close to the proximal capturing net.
Further, the diameter of the broken bolt spiral wire is 0.1-0.5 mm, the outer diameter of the end with the larger outer diameter is 1-6 mm, the number of turns is 2-10, and the pitch is 1-5 mm.
Further, the broken bolt spiral wire comprises a core wire made of nickel-titanium alloy material and a coating layer made of stainless steel material, and the coating layer is coated on the core wire.
Further, the mesh area of the proximal capturing net is 1.5-3 times that of the distal capturing net.
Further, the thrombus capturing net further comprises a middle capturing net, and the middle capturing net is arranged between the far-end capturing net and the near-end capturing net; the mesh area of the middle capturing net is 1-2 times of that of the far-end capturing net.
Further, the maximum outer diameter of the far-end capturing net is 1 mm-6 mm; the length of the thrombus catching net is 10 mm-50 mm.
Further, the thrombus taking device further comprises a thrombus binding coating, wherein the thrombus binding coating is coated on the thrombus capturing net and the broken thrombus spiral wire; the thrombus bonding coating is formed by combining any one or more of polydopamine membranes, amine functionalized-cyclooctyne derivatives and bio-orthogonal alkyne-azide copper-free and DNA interaction agents.
Further, the thrombus taking device also comprises a developing mark, wherein the developing mark is arranged on the far-end capturing net and/or the near-end capturing net and/or the middle capturing net; the developing mark is formed by combining any one or more of platinum-tungsten alloy, platinum-iridium alloy, gold and tantalum.
The thrombus taking device provided by the invention can realize the following technical effects:
1. the thrombus is fully cut through the broken thrombus spiral wire, so that the high-load thrombus and the heart-source thrombus with harder texture are cut into thrombus blocks, and meanwhile, the thrombus taking device also has the function of cutting the thrombus with softer texture, so that the difficulty of thrombus taking is reduced. Meanwhile, through the matching of the big mesh of the near-end capturing net and the small mesh of the far-end capturing net, the cut thrombus is intercepted and captured, the near-end capturing net intercepts and captures the big thrombus blocks for the first time, and the small thrombus blocks smaller than the mesh of the near-end capturing net are intercepted and captured for the second time by the far-end capturing net. Finally, the thrombus caught by the thrombus catching net is taken out of the human body by matching with the suction catheter, so that the risk of thrombus escape is avoided. Through the complement of the broken bolt spiral wire and the thrombus catching net, the occluded blood vessel can be quickly recaptured. The vascular portion may be allowed to resume circulation after the thrombus has been cut.
2. The thrombus-binding coating is arranged on the thrombus-catching net and the broken thrombus spiral wire, so that the catching capability of the cut thrombus can be further improved.
The foregoing general description and the following description are exemplary and explanatory only and are not restrictive of the invention.
Drawings
One or more embodiments are illustrated by way of example and not limitation in the figures of the accompanying drawings, in which like references indicate similar elements, and in which:
FIG. 1 is a background art diagram;
FIG. 2 is a schematic diagram of an embodiment of a thrombolysis device according to the present invention;
FIG. 3 is a schematic illustration of one embodiment of a thrombus capture mesh of a thrombectomy device of the present invention;
FIG. 4 is a schematic view of one embodiment of a distal capture net of a thrombolytic device of the present invention;
FIG. 5 is a schematic diagram II of an embodiment of a thrombus capture mesh of a thrombolytic device of the present invention;
fig. 6 is an enlarged view of a portion a of fig. 2;
FIG. 7 is a schematic view of an embodiment of a shredded spiral wire and shredded sleeve of a thrombus extraction device according to the present invention;
FIG. 8 is a schematic diagram II of an embodiment of a shredded spiral wire and shredded sleeve of a thrombus extraction device of the present invention;
FIG. 9 is a schematic diagram II of an embodiment of a thrombus removal device of the present invention;
FIG. 10 is a schematic view of an embodiment of a development flag arrangement of a thrombolytic device of the present invention;
FIG. 11 is a schematic partial cross-sectional view of one embodiment of a broken bolt spiral wire of a thrombolytic device of the present invention;
FIG. 12 is a schematic view of an embodiment of a thrombolytic device of the present invention in a compressed state;
FIG. 13 is a schematic view of an embodiment of a thrombus removal device of the present invention intercepting a cut thrombus;
fig. 14 is a schematic view of an embodiment of a thrombus breaking screw of the thrombus removal device of the present invention.
Reference numerals:
1. a thrombus capture net; 11. a distal capture net; 12. a proximal capture net; 13. a headend; 14. a middle catching net; 2. pushing the guide wire; 3. a suction catheter; 4. breaking bolt sleeve; 5. breaking bolt spiral wires; 51. a core wire; 52. a coating layer; 6. a handle; 61. a through hole; 7. a fixing wire; 71. fixing the column; 8. developing the mark.
Detailed Description
For a more complete understanding of the nature and the technical content of the embodiments of the present invention, reference should be made to the following detailed description of embodiments of the invention, taken in conjunction with the accompanying drawings, which are meant to be illustrative only and not limiting of the embodiments of the invention. In the following description of the technology, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the disclosed embodiments. However, one or more embodiments may still be practiced without these details. In other instances, well-known structures and devices may be shown simplified in order to simplify the drawing.
The terms first, second and the like in the description and in the claims of embodiments of the invention and in the above-described figures are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate in order to describe embodiments of the invention herein. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion.
In the embodiments of the present invention, the terms "upper", "lower", "inner", "middle", "outer", "front", "rear", and the like indicate the azimuth or the positional relationship based on the azimuth or the positional relationship shown in the drawings. These terms are only used to facilitate a better description of embodiments of the invention and their examples and are not intended to limit the scope of the indicated devices, elements or components to the particular orientation or to be constructed and operated in a particular orientation. Also, some of the terms described above may be used to indicate other meanings in addition to orientation or positional relationships, for example, the term "upper" may also be used to indicate some sort of attachment or connection in some cases. The specific meaning of these terms in embodiments of the present invention will be understood by those of ordinary skill in the art in view of the specific circumstances.
In addition, the terms "disposed," "connected," "secured" and "affixed" are to be construed broadly. For example, "connected" may be in a fixed connection, a removable connection, or a unitary construction; may be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements, or components. The specific meaning of the above terms in the embodiments of the present invention will be understood by those of ordinary skill in the art according to the specific circumstances.
The term "plurality" means two or more, and "plurality" means two or more.
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
As shown in fig. 2 to 4, the invention discloses a thrombus removing device, which comprises a thrombus catching net 1, a pushing guide wire 2, a suction catheter 3, a thrombus breaking sleeve 4 and a thrombus breaking spiral wire 5. The thrombus-catching net 1 comprises a distal-catching net 11 and a proximal-catching net 12, one end of the distal-catching net 11 is connected with one end of the proximal-catching net 12, the distal-catching net 11 and the proximal-catching net 12 form the thrombus-catching net 1, and the length L1 of the thrombus-catching net 1 is 10 mm-50 mm, so that the thrombus-catching net can be ensured to have enough length to catch broken thrombus blocks. The end of the distal capturing net 11, which is far away from the proximal capturing net 12, is configured with a head end 13, and the head end 13 is located at the center of the distal capturing net 11. The end of the proximal capturing net 12 far away from the distal capturing net 11 is fixedly connected with one end of the pushing guide wire 2.
Preferably, as shown in fig. 3, the cross-sectional shape of the distal capture net 11 and the cross-sectional shape of the proximal capture net 12 are both funnel-shaped. The outer diameter of one end of the distal capturing net 11 is larger than that of the other end, and the end of the distal capturing net 11 with the smaller outer diameter is provided with a head end 13. The outer diameter of one end of the proximal capturing net 12 is larger than that of the other end of the proximal capturing net, and one end of the proximal capturing net 12 with the smaller outer diameter is fixedly connected with one end of the pushing guide wire 2. The end with the larger outer diameter of the distal capturing net 11 is fixedly connected with the end with the larger outer diameter of the proximal capturing net 12 to form the thrombus capturing net 1. When the thrombus-catching net 1 is in use, firstly, the proximal-end catching net 12 intercepts large thrombus, then small thrombus enters the space of the thrombus-catching net 1, and the distal-end catching net 11 intercepts small thrombus again, so that large thrombus and small thrombus formed by broken thrombus blocks can be fully intercepted.
Preferably, as shown in fig. 4, the outer diameter D1 of the end of the distal capturing net 11 far from the head end 13 is the largest, and the value of the outer diameter D1 of the end ranges from 1mm to 6mm, so that the thrombus removing device of the present invention is suitable for not only aortic vessels, but also intracranial medium and small vessels.
Alternatively, the thrombus-capturing net 1 can be a single laser engraved stent or a single woven stent or a laser engraved composite stent or a woven composite stent.
Preferably, the thrombus-catching net 1 is made of nickel-titanium alloy material.
Alternatively, as shown in fig. 2 and 3, the distal capturing net 11 may be a small-mesh metal net or a small-mesh polymer film-covered net, so as to facilitate interception and capturing of small thrombus. The proximal capture net 12 can be a large-mesh metal net or a large-mesh polymer film-covered net, which is beneficial to intercept and capture large thrombus. The mesh area of the proximal capture net 12 is 1.5-3 times that of the distal capture net 11. Preferably, the mesh area of the proximal capture net 12 is 2 times or 2.5 times the mesh area of the distal capture net 11. Thus, the thrombus-catching net 1 can have the function of double interception and catching of thrombus.
Optionally, as shown in fig. 2 and 5, the thrombus-capturing device 1 further includes a middle capturing device 14, where the middle capturing device 14 is disposed between the distal capturing device 11 and the proximal capturing device 12. One end of the middle catching net 14 is connected with one end of the far-end catching net 11 far away from the head end 13, the other end of the middle catching net 14 is connected with one end of the near-end catching net 12 far away from the pushing guide wire 2, the far-end catching net 11, the middle catching net 14 and the near-end catching net 12 enclose the thrombus catching net 1 in a cage structure together, the length L2 of the thrombus catching net 1 is 10-50 mm, the catching force of thrombus broken by the broken bolt spiral wire 5 is further enhanced, and the thrombus catching net 1 has the function of triple interception catching thrombus.
Preferably, as shown in fig. 5, the middle capture net 14 has a larger mesh area than the distal capture net 11, while the middle capture net 14 has a smaller mesh area than the proximal capture net 12. The mesh area of the middle catching net 14 is 1-2 times that of the far-end catching net 11. Preferably, the mesh area of the middle capture net 14 is 1.5 times the mesh area of the distal capture net 11.
As shown in fig. 2, the aspiration catheter 3 is sleeved on the end of the push wire 2 remote from the proximal capture net 12. The broken bolt sleeve 4 is sleeved at one end of the pushing guide wire 2 far away from the proximal capturing net 12, and meanwhile, the broken bolt sleeve 4 is positioned between the suction catheter 3 and the pushing guide wire 2. The broken bolt spiral wire 5 adopts a variable-diameter spring wire, and the outer diameter of one end of the broken bolt spiral wire 5 is smaller than the outer diameter of the other end of the broken bolt spiral wire. The broken bolt spiral wire 5 is sleeved on the pushing guide wire 2, and one end of the broken bolt spiral wire 5 is connected with one end of the broken bolt sleeve 4 close to the proximal capturing net 12.
Optionally, as shown in fig. 2 and 6, the thrombus removing device further includes a handle 6, wherein a through hole 61 is formed in the handle 6, the through hole 61 penetrates the entire longitudinal direction of the handle 6, and the through hole 61 is located at the center of the handle 6, so that the handle 6 can be rotated more conveniently. The end of the broken bolt sleeve 4 far away from the proximal capturing net 12 is fixedly connected with one end of the handle 6, and at this time, the space in the broken bolt sleeve 4 is communicated with the through hole 61 of the handle 6. One end of the pushing guide wire 2 far away from the thrombus catching net 1 sequentially penetrates through the broken bolt spiral wire 5, the broken bolt sleeve 4 and the through hole 61 of the handle 6 to be exposed to the outside. The handle 6 drives the thrombus breaking sleeve 4, so that the operation of operators is facilitated.
Alternatively, as shown in fig. 2 and 7, the end of the broken bolt spiral wire 5 with a small outer diameter is fixedly connected with the end of the broken bolt sleeve 4 near the proximal end capturing net 12, and the arrangement mode is suitable for cutting soft thrombus blocks, and meanwhile, the disturbance to the vascular wall is smaller. Preferably, the end of the broken bolt spiral wire 5 with the smaller outer diameter is further provided with a fixing wire 7, and the fixing wire 7 is embedded into one end of the broken bolt sleeve 4 close to the proximal capturing net 12 when the broken bolt sleeve 4 is formed, so that the broken bolt spiral wire 5 is stably fixed on the broken bolt sleeve 4. The fixing column 71 is constructed at one end of the fixing wire 7 far away from the broken bolt spiral wire 5, and the diameter of the fixing column 71 is larger than that of the fixing wire 7, so that the broken bolt spiral wire 5 can be more firmly embedded into one end of the broken bolt sleeve 4 close to the proximal end capturing net 12 through the fixing wire 7.
Alternatively, as shown in fig. 2 and 7, the end of the broken bolt spiral wire 5 with the larger outer diameter is fixedly connected with the end of the broken bolt sleeve 4 close to the proximal capturing net 12, and the arrangement mode is suitable for cutting hard thrombus blocks, and meanwhile the broken bolt spiral wire 5 can have stronger thrombus cutting and decomposing capacity. Preferably, the end of the broken bolt spiral wire 5 with the larger outer diameter is further provided with a fixing wire 7, and the fixing wire 7 is embedded into one end of the broken bolt sleeve 4 close to the proximal capturing net 12 when the broken bolt sleeve 4 is formed, so that the broken bolt spiral wire 5 is stably fixed on the broken bolt sleeve 4. The fixing column 71 is constructed at one end of the fixing wire 7 far away from the broken bolt spiral wire 5, and the diameter of the fixing column 71 is larger than that of the fixing wire 7, so that the broken bolt spiral wire 5 can be more firmly embedded into one end of the broken bolt sleeve 4 close to the proximal end capturing net 12 through the fixing wire 7.
Preferably, as shown in fig. 7 and 8, the value range of the wire diameter of the broken bolt spiral wire 5 is 0.1 mm-0.5 mm, the value range of the outer diameter D2 of the end of the broken bolt spiral wire 5 with the larger outer diameter is 1 mm-6 mm, the value range of the number of turns of the broken bolt spiral wire 5 is 2-10, the pitch of the broken bolt spiral wire 5 is 1 mm-5 mm, and by limiting various parameters of the broken bolt spiral wire 5, the thrombus cutting efficiency can be improved to the greatest extent.
When the wire diameter of the broken bolt spiral wire 5 is smaller than 0.1mm, the structural strength of the broken bolt spiral wire 5 is insufficient; when the diameter of the broken bolt spiral wire 5 is larger than 0.5mm, the structure of the broken bolt spiral wire 5 is too hard, and the wall of the blood vessel is easily damaged when the thrombus is broken. When the outer diameter D2 of the end of the broken bolt spiral wire 5 with the larger outer diameter is smaller than 1mm, the structural strength of the broken bolt spiral wire 5 is insufficient; when the outer diameter D2 of the end of the broken bolt spiral wire 5 with the larger outer diameter is larger than 6mm, the broken bolt spiral wire can be directly clamped in a blood vessel, so that thrombus cannot be broken, and bleeding is easy to occur. When the number of turns of the broken bolt spiral wire 5 is smaller than 2, the broken bolt spiral wire 5 has insufficient breaking force on thrombus blocks; when the number of turns of the broken-bolt spiral wire 5 is larger than 10, the broken-bolt spiral wire 5 is excessively disturbed on the wall of the blood vessel, and even bleeding of the wall of the blood vessel can be caused. When the pitch of the broken bolt spiral wire 5 is smaller than 1mm, the structure of the broken bolt spiral wire 5 is too hard to fully cut thrombus; when the pitch of the broken bolt spiral wire 5 is larger than 5mm, the structure of the broken bolt spiral wire 5 is too soft, and the cutting of thrombus blocks is insufficient.
Optionally, the thrombi removing device further comprises a thrombus binding coating which is coated on the thrombus capturing net 1 and the broken thrombus spiral wire 5. After the thrombus is broken into small thrombus blocks by the broken thrombus spiral wire 5, the broken thrombus spiral wire 5 and the thrombus catching net 1 are made to adhere to the small thrombus blocks, so that the broken thrombus spiral wire 5 and the thrombus catching net 1 can be made to have the capability of adhering and fixing the thrombus. Preferably, the thrombus binding coating is formed by any one or more of polydopamine membranes, amine functionalized-cyclooctyne derivatives, bioorthogonal alkyne-azide copper-free and DNA interaction agents, so that the binding and fixing capacity of the broken thrombus spiral wires 5 and the thrombus capture net 1 to thrombus can be further enhanced.
Optionally, as shown in fig. 5 and 10, the thrombus removing device further includes a developing mark 8, where the developing mark 8 may be made of any one material or a combination of materials of platinum-tungsten alloy, platinum-iridium alloy, gold and tantalum. The developing mark 8 is arranged on the thrombus-catching net 1, so that the thrombus-catching net 1 can be developed conveniently.
Alternatively, as shown in fig. 5, when the developing mark 8 is a developing spring, and the thrombus-capturing net 1 includes a distal capturing net 11 and a proximal capturing net 12, the developing spring is disposed at a position of the distal capturing net 11 near the head end 13, and the developing spring is disposed at an end of the proximal capturing net 12 near the pushing guide wire 2. Or, when the developing mark 8 is a developing spring, and the thrombus-catching net 1 includes a distal-end catching net 11, a proximal-end catching net 12 and a middle-part catching net 14, the developing spring is disposed at a position of the distal-end catching net 11 near the head end 13, and the developing spring is disposed at one end of the proximal-end catching net 12 near the pushing guide wire 2, which may, of course, be disposed on the braided wire of the middle-part catching net 14. Such an arrangement facilitates local visualization of the thrombus-catch net 1 and determines the position of the thrombus-catch net 1 from the location of the visualization.
Alternatively, as shown in fig. 10, when the developing mark 8 is a developing wire, and the thrombus-capturing net 1 includes a distal capturing net 11 and a proximal capturing net 12, one end of the developing wire is disposed at a position where the distal capturing net 11 is close to the head end 13, the other end of the developing wire is sequentially wound around the distal capturing net 11 and the proximal capturing net 12, and finally the other end of the developing wire is disposed at one end where the proximal capturing net 12 is close to the pushing guide wire 2. Or, when the developing mark 8 is a developing wire, and the thrombus-catching net 1 includes a distal-end catching net 11, a proximal-end catching net 12 and a middle-end catching net 14, one end of the developing wire is disposed at a position where the distal-end catching net 11 is close to the head end 13, the other end of the developing wire is sequentially wound around the distal-end catching net 11, the middle-end catching net 14 and the proximal-end catching net 12, and finally the other end of the developing wire is disposed at one end where the proximal-end catching net 12 is close to the pushing guide wire 2. Such an arrangement facilitates the overall visualization of the thrombus-catch net 1 and determines the position of the thrombus-catch net 1 from the visualization position.
Alternatively, the end of the pushing guide wire 2 and the end of the thrombus breaking sleeve 4 near the thrombus breaking spiral wire 5 can be covered by a polymer sheath or a single-layer hydrophobic coating or a multi-layer hydrophobic coating or a single-layer hydrophilic coating or a multi-layer hydrophilic coating. When a polymer jacket is employed, the polymer jacket may be made from any one or more of the LDPE, PE, HDPE, PTFE materials. The length of the polymer sheath is 200 mm-700 mm. When a coating material is used, any of PTFE, PAM, parylene, PVP materials may be used as the coating material. The thickness of the coating is less than 10um, and the cladding length of the coating is 200 mm-700 mm. The device can enhance the conveying performance of the thrombus taking device and reduce the resistance in pushing.
Alternatively, as shown in fig. 11, the broken bolt spiral wire 5 includes a core wire 51 and a coating layer 52, the core wire 51 is made of nickel-titanium alloy material, the coating layer 52 is made of stainless steel material, and the coating layer 52 coats the core wire 51. After the core wire 51 is covered with the covering layer 52, the diameter-variable spring wire, that is, the broken-pin spiral wire 5 is formed by winding. The broken bolt spiral wire 5 can be round wire or flat wire. The memory metal is adopted as the core wire, so that the broken bolt spiral wire 5 has a self-expanding effect, and the embedding effect on thrombus is better, thereby being more beneficial to cutting the thrombus.
Application scenario of an exemplary embodiment:
as shown in fig. 12, the thrombus extraction device is in a non-operating state, and one end of the broken-bolt spiral wire 5 and one end of the broken-bolt sleeve 4 are both positioned in the suction catheter 3, and at this time, the broken-bolt spiral wire 5 is in a compressed state. Meanwhile, one ends of the thrombus capturing net 1 and the pushing guide wire 2 are both positioned in the thrombus breaking sleeve 4.
As the thrombus removal device enters the vessel and reaches the thrombus. As shown in fig. 2, 5 to 7, 10, 13 and 14, the aspiration catheter 3 is passed through the thrombus to the distal end of the thrombus, the distal end being the end far away from the operator at the time of surgery, and the proximal end being the end near the operator at the time of surgery. By driving the pushing wire 2 distally and releasing the thrombus-catch net 1 into the blood vessel, the thrombus-catch net 1 is located at the distal end of the thrombus. The thrombus-catch net 1 is in a non-compressed state after release and collides with the vessel wall. The suction catheter 3 is then moved proximally such that the orifice of the suction catheter 3 is located at the proximal end of the thrombus, i.e. the thrombus is located between the thrombus-capturing mesh 1 and the orifice of the suction catheter 3.
The handle 6 drives the thrombus-breaking sleeve 4 to move distally in the suction catheter 3, the thrombus-breaking sleeve 4 drives the thrombus-breaking spiral wire 5 to be released into the blood vessel from the orifice of the suction catheter 3, and the thrombus-breaking spiral wire 5 is in a non-compressed state after being released. Then, by pushing and pulling the handle 6, the operator can drive the thrombus-breaking sleeve 4 to move along the length direction of the pushing guide wire 2, the thrombus-breaking sleeve 4 drives the thrombus-breaking spiral wire 5 to move towards or away from the thrombus-capturing net 1, and the thrombus is longitudinally cut. Simultaneously, the operator can also rotate handle 6, and handle 6 can drive garrulous bolt sleeve pipe 4 to rotate around pushing wire 2, and garrulous bolt sleeve pipe 4 rotates and drives garrulous bolt spiral silk 5 to rotate around pushing wire 2 to cut the circumference to the thrombus. Thus, the broken spiral wire 5 can sufficiently cut the thrombus, and cut the thrombus into a large thrombus and a small thrombus. A part of small thrombus is stuck by the broken thrombus spiral wire 5, in the rest thrombus, the large thrombus is stuck and caught and fixed by the proximal catching net 12, and the other part of small thrombus enters the inside of the thrombus catching net 1 through the mesh of the proximal catching net 12 and is stuck and caught and fixed by the middle catching net 14 and the distal catching net 11, so that all thrombus after being cut can be caught and prevented from escaping to the distal end.
Then, the thrombus-breaking sleeve 4 is driven to move proximally in the suction catheter 3 through the handle 6, the thrombus-breaking sleeve 4 drives the thrombus-breaking spiral wire 5 and a part of small thrombus stained on the thrombus-breaking spiral wire 5 to pass through the suction catheter 3 from the blood vessel to the outside, finally, the thrombus-capturing net 1 is driven to move proximally through the pushing guide wire 2, and the thrombus-capturing net 1 carries the rest of thrombus captured by the thrombus-capturing net 1 to pass through the suction catheter 3 to the outside, so that the thrombus-taking device is taken out from the blood vessel, and the thrombus-taking operation is completed.
The above description and the drawings illustrate embodiments of the invention sufficiently to enable those skilled in the art to practice them. Other embodiments may include structural and other modifications. The embodiments represent only possible variations. Individual components and functions are optional unless explicitly required, and the sequence of operations may vary. Portions and features of some embodiments may be included in, or substituted for, those of others. The embodiment of the present invention is not limited to the structure that has been described above and shown in the drawings, and various modifications and changes may be made without departing from the scope thereof. The scope of the invention is limited only by the appended claims.
Claims (9)
1. A thrombolytic device, comprising:
the thrombus capturing net (1) comprises a distal capturing net (11) and a proximal capturing net (12) connected with one end of the distal capturing net (11); the far-end capturing net (11) adopts small meshes, and the near-end capturing net (12) adopts large meshes;
one end of the pushing guide wire (2) is connected with the proximal capturing net (12);
a suction catheter (3) sleeved at the other end of the pushing guide wire (2);
the thrombus breaking sleeve (4) is sleeved at the other end of the pushing guide wire (2) and is positioned between the suction catheter (3) and the pushing guide wire (2);
the broken bolt spiral wire (5) is sleeved on the pushing guide wire (2); one end of the broken bolt spiral wire (5) with the large outer diameter is fixedly connected with one end of the broken bolt sleeve (4) close to the near-end capturing net (12), or one end of the broken bolt spiral wire (5) with the small outer diameter is fixedly connected with one end of the broken bolt sleeve (4) close to the near-end capturing net (12);
wherein the broken bolt sleeve (4) can drive the broken bolt spiral wire (5) to move along the length direction of the pushing guide wire (2); and/or the broken bolt sleeve (4) can drive the broken bolt spiral wire (5) to rotate around the pushing guide wire (2).
2. The thrombectomy device of claim 1, wherein,
the broken bolt spiral wire (5) comprises a reducing spring wire, and the outer diameter of one end of the broken bolt spiral wire is smaller than that of the other end of the broken bolt spiral wire.
3. The thrombolytic device according to claim 2, wherein,
the diameter of the broken bolt spiral wire (5) is 0.1-0.5 mm, the outer diameter of the end with the larger outer diameter is 1-6 mm, the number of turns is 2-10, and the pitch is 1-5 mm.
4. The thrombectomy device of claim 3,
the broken bolt spiral wire (5) comprises a core wire (51) made of nickel-titanium alloy material and a coating layer (52) made of stainless steel material, and the coating layer (52) is coated on the core wire (51).
5. The thrombolytic device according to any of claim 1 to 4, wherein,
the mesh area of the proximal capturing net (12) is 1.5-3 times that of the distal capturing net (11).
6. The thrombectomy device according to claim 5, wherein the thrombus capture mesh (1) further comprises:
a middle capturing net (14) arranged between the far capturing net (11) and the near capturing net (12);
the mesh area of the middle catching net (14) is 1-2 times of the mesh area of the far-end catching net (11).
7. The thrombectomy device of claim 6,
the maximum outer diameter of the far-end capturing net (11) is 1 mm-6 mm;
the length of the thrombus catching net (1) is 10 mm-50 mm.
8. The thrombolytic device of claim 7, further comprising:
a thrombus binding coating coated on the thrombus capture net (1) and the broken thrombus spiral wire (5);
the thrombus bonding coating is formed by combining any one or more of polydopamine membranes, amine functionalized-cyclooctyne derivatives and bio-orthogonal alkyne-azide copper-free and DNA interaction agents.
9. The thrombolytic device of claim 8, further comprising:
the development mark (8) is arranged on the far-end capturing net (11) and/or the near-end capturing net (12) and/or the middle capturing net (14);
the developing mark (8) is formed by combining any one or more of platinum tungsten alloy, platinum iridium alloy, gold and tantalum.
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| CN202311473810.4A CN117204917B (en) | 2023-11-08 | 2023-11-08 | Bolt taking device |
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| CN112472210A (en) * | 2020-12-15 | 2021-03-12 | 上海融脉医疗科技有限公司 | Thrombus crushing and collecting mechanism of thrombus capturing and removing catheter device |
| CN218338497U (en) * | 2022-07-05 | 2023-01-20 | 昆明理工大学 | Blood vessel far-end protection device for capturing thrombus fragments |
| CN115737059A (en) * | 2022-11-08 | 2023-03-07 | 滨州职业学院 | Spiral type non-cutting bolt taking device |
| CN115919412A (en) * | 2022-12-05 | 2023-04-07 | 上海恩盛医疗科技有限公司 | Blood vessel thrombus taking device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11259824B2 (en) * | 2011-03-09 | 2022-03-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
| EP3682821B1 (en) * | 2014-11-26 | 2022-05-11 | Neuravi Limited | A clot retrieval device for removing an occlusive clot from a blood vessel |
| JP7169971B2 (en) * | 2016-11-23 | 2022-11-11 | マイクロベンション インコーポレイテッド | Obstruction removal system |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396295A (en) * | 2007-09-29 | 2009-04-01 | 成正辉 | Blood thrombus and embolus resectoscope |
| CN112472210A (en) * | 2020-12-15 | 2021-03-12 | 上海融脉医疗科技有限公司 | Thrombus crushing and collecting mechanism of thrombus capturing and removing catheter device |
| CN218338497U (en) * | 2022-07-05 | 2023-01-20 | 昆明理工大学 | Blood vessel far-end protection device for capturing thrombus fragments |
| CN115737059A (en) * | 2022-11-08 | 2023-03-07 | 滨州职业学院 | Spiral type non-cutting bolt taking device |
| CN115919412A (en) * | 2022-12-05 | 2023-04-07 | 上海恩盛医疗科技有限公司 | Blood vessel thrombus taking device |
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