CN117179956A

CN117179956A - Pusher and conveyor and conveying system with same

Info

Publication number: CN117179956A
Application number: CN202210598557.4A
Authority: CN
Inventors: 徐澧; 李阳; 王普凯
Original assignee: Hangzhou Wei Qiang Medical Technology Co ltd
Current assignee: Hangzhou Wei Qiang Medical Technology Co ltd
Priority date: 2022-05-30
Filing date: 2022-05-30
Publication date: 2023-12-08

Abstract

The invention relates to a pushing device, and a conveyor and a conveying system with the pushing device. The pushing device is used for pushing an implant to a target position and releasing the implant at the target position, the implant is provided with a first connecting part at the proximal end of the implant and is used for being detachably connected with the pushing device, the pushing device comprises a pushing piece and a locking piece, and the pushing piece and the locking piece can move axially relative to each other so as to enable the pushing device to be switched between a locking state and an unlocking state; in the locked state, the first distal section of the pusher and the second distal section of the locking member cooperate to form a closed loop structure to lock the first connection of the implant; in the unlocked state, the closed loop structure is opened to release the first connection of the implant. The pushing device is convenient to operate and easy to release the implant.

Description

Pusher and conveyor and conveying system with same

Technical Field

The invention relates to the field of medical instruments, in particular to a pushing device, and a conveyor and a conveying system with the pushing device.

Background

In recent years, interventional therapy has been increasingly used in clinical applications. Interventional therapy refers to the treatment of corresponding diseases by placing medical instruments such as implants and the like on the heart, arteries, veins and other parts of a human body through a catheter. For example, a Vena Cava Filter (VCF) may be placed into the inferior vena cava of a patient by catheterization, capturing the shed thrombus, preventing it from migrating up the venous system to the heart and lung, causing pulmonary arterial embolism; alternatively, the left atrial appendage occlusion device may be delivered to the left atrial appendage via a catheter intervention to prevent thrombus from ascending to the brain due to atrial fibrillation, causing stroke or other systemic embolism. Such implants all require delivery to the respective body part by means of a delivery device, and then the pushing means in the delivery device are disengaged from the implant to leave the implant in the body. However, the existing pushing device often has the technical problem that the implant is difficult to release when the implant is released.

Disclosure of Invention

In view of the above, the present invention aims to provide a pushing device and a conveyor and a conveying system having the pushing device, which can solve or at least alleviate the above problems to some extent.

To this end, in one aspect the present invention provides a pusher for pushing an implant to a target location and releasing the implant at the target location, the implant being provided with a first connection at its proximal end for releasable connection with the pusher, the pusher comprising a pusher and a locking member, and the pusher and the locking member being axially movable relative to each other for switching the pusher between a locked state and an unlocked state; in the locked state, the first distal section of the pusher and the second distal section of the locking member cooperate to form a closed loop structure to lock the first connection of the implant; in the unlocked state, the closed loop structure is opened to release the first connection of the implant.

The pushing device forms a closed loop structure capable of stably locking the first connecting part of the implant through the pushing piece and the locking piece, and opens the closed loop structure through the axial relative movement of the pushing piece and the locking piece so as to release the first connecting part of the implant, thereby being convenient to operate. In particular, the closed loop structure described herein does not require that a strict geometric loop must be formed, as long as neither the first distal section of the pusher nor the second distal section of the locking member has a sharp pointed hook. Thus, after the pushing member and the locking member are moved axially relative to each other to open the closed loop structure, the first connecting portion of the implant can be smoothly disengaged from the pushing means along the first distal section of the pushing member and/or the second distal section of the locking member, even without any obstruction, without any hook portion with sharp corners catching the first connecting portion of the implant, and thus the implant can be easily disengaged.

On the other hand, the invention also provides a conveyor, which comprises a sheath tube and the pushing device, wherein the sheath tube is provided with a tube cavity, and the pushing device can be movably accommodated in the tube cavity of the sheath tube.

In yet another aspect, the present invention provides a delivery system comprising the delivery device and an implant having a compressed configuration received within the lumen of the sheath and an expanded configuration released from the lumen of the sheath.

Drawings

FIG. 1 is a schematic diagram of a conveyor system according to a first embodiment of the invention;

FIG. 2 is a schematic illustration of the configuration of the pusher device of the delivery system of FIG. 1, wherein the distal end of the pusher device is partially enlarged;

FIG. 3 is a partial cross-sectional view of the pusher shown in FIG. 2;

FIG. 4 is a front view of the base and second attachment portion of the pusher shown in FIG. 2;

FIG. 5 is a cross-sectional view of the base and second connecting portion of FIG. 4;

FIG. 6 is a schematic view of the overall structure of the locking member of the pusher shown in FIG. 2;

FIG. 7 is a schematic overall construction of another alternative embodiment of the locking element of FIG. 6;

FIG. 8 is a schematic view of the pusher device of FIG. 2 in a locked position for delivery of an implant into the inferior vena cava via the left iliac vein;

FIG. 9 is a schematic view of the pusher device of FIG. 2 in an unlocked state for delivering an implant into the inferior vena cava via the left iliac vein;

FIG. 10 is a schematic view of the pusher device of FIG. 2 in an unlocked state for delivering an implant into the inferior vena cava via the right iliac vein;

fig. 11 is a schematic structural diagram of a pushing device according to a second embodiment of the present invention;

FIG. 12 is a cross-sectional view of the pusher device of FIG. 11;

FIG. 13 is a front view of the base and second attachment portion of the pusher shown in FIG. 11;

FIG. 14 is a right side view of the base and second connecting portion of FIG. 13;

FIG. 15 is a cross-sectional view of the base and second connecting portion of FIG. 13;

FIG. 16 is a schematic view of the overall structure of the locking element of the pusher shown in FIG. 11;

FIG. 17 is a cross-sectional view of the locking element of FIG. 16;

FIG. 18 is a schematic view of the pusher device of FIG. 11 in a locked position for delivery of an implant into the inferior vena cava via the left iliac vein;

FIG. 19 is a schematic view of the pusher device of FIG. 11 in an unlocked state delivering an implant into the inferior vena cava via the left iliac vein with the arcuate sections flared radially outward;

FIG. 20 is a schematic view of the pusher device of FIG. 11 in an unlocked state delivering an implant into the inferior vena cava via the left iliac vein with the arcuate section retracted into the guide bore;

fig. 21 is a schematic structural view of a pushing device according to a third embodiment of the present invention;

FIG. 22 is a cross-sectional view of the pusher device of FIG. 21;

FIG. 23 is a front view of the base and second attachment portion of the pusher shown in FIG. 21;

FIG. 24 is a cross-sectional view of the base and second connecting portion of FIG. 23;

FIG. 25 is a schematic view of the pusher device of FIG. 21 in a locked position for delivery of an implant into the inferior vena cava via the left iliac vein;

FIG. 26 is a schematic view of the pusher device of FIG. 21 in an unlocked state delivering an implant into the inferior vena cava via the left iliac vein with the arcuate sections flared radially outward;

fig. 27 is a schematic view of the pusher device of fig. 21 in an unlocked state delivering an implant into the inferior vena cava via the left iliac vein with the rod-shaped segment retracted into the guide bore.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention. In addition, as long as there is no conflict or conflict between the embodiments described below, the same or similar concepts or processes may not be described in detail in some embodiments.

It is first noted that "proximal" as used herein refers to the end of the device or element that is proximal to the operator. "distal" refers to the end of the device or element that is remote from the operator. "initial end" refers to the end face of the device or element that is the most proximal end. "distal" refers to the end face of the device or element that is furthest away. "axial" refers to a direction coincident with or parallel to the central axis of a device or element. "radial" refers to a direction perpendicular or substantially perpendicular to the axial direction and along a radius or diameter of a device or element. "circumferential" refers to a direction about the axial direction.

It should be noted that the above terms indicating orientation or positional relationship are merely for convenience of description and simplification of the description, and are not intended to indicate or imply that the apparatus or elements in question must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be construed as limiting the invention.

Referring to fig. 1, a first embodiment of the present invention provides a delivery system 1 comprising a delivery device 2 and an implant 3, the delivery device 2 being adapted to deliver the implant 3 to a target site and release it. Specifically, the delivery device 2 includes a sheath 4 having a lumen 40, and a pushing device 100 movably accommodated in the lumen 40, and specifically, the pushing device 100 is movably disposed in the lumen 40 along an axial direction. The implant 3 has a compressed configuration housed within the lumen 40 and an expanded configuration released from the lumen 40. Preferably, the implant 3 is made of a material having a shape memory function such that the implant 3 is self-expandable to its expanded configuration after release from the sheath 4. The pushing device 100 is used to push and release the implant 3 to a target location. Specifically, the proximal end of the implant 3 is provided with a first connection portion 30 (as shown in fig. 8) for detachable connection with the pushing device 100. Alternatively, the first connecting portion 30 may have a hook shape or a ring shape or another shape having at least one through hole. The implant 3 includes, but is not limited to, a filter, stent, heart valve clamp, left atrial appendage occluder, vascular plug, or lung volume reducing elastomer, etc.

Referring to fig. 2, the pusher 100 includes a pusher 110 and a lock 120. The pusher 110 and the lock 120 are axially movable relative to each other to switch the pusher 100 between a locked state and an unlocked state. Referring to fig. 8, in the locked state, the first distal section 111 of the pusher 110 and the second distal section 121 of the locking member 120 cooperate to form a closed loop structure 130 to lock the first connection 30 of the implant 3. Referring to fig. 9, in the unlocked state, the closed loop structure 130 is opened to release the first connection 30 of the implant 3.

The pushing device 100 of the present embodiment forms a closed loop structure 130 capable of stably locking the first connection part 30 of the implant 3 by the pushing member 110 and the locking member 120, and opens the closed loop structure 130 by the axial relative movement of the pushing member 110 and the locking member 120 to release the first connection part 30 of the implant 3, thereby facilitating the operation. It is noted that the closed loop structure 130 does not have to be formed in a strictly geometric loop, as long as neither the first distal section 111 of the pusher member 110 nor the second distal section 121 of the locking member 120 has a distinct hook-shaped portion with sharp corners. For example, it may be that the first distal section 111 of the pusher 110 and the second distal section 121 of the lock 120 are both arc-shaped sections, or that the first distal section 111 of the pusher 110 is arc-shaped and the second distal section 121 of the lock 120 is straight-shaped, or that the first distal section 111 of the pusher 110 is straight-shaped and the second distal section 121 of the lock 120 is arc-shaped. When the pusher 110 and the locking member 120 are moved axially relative to each other to open the closed loop structure 130, the first connecting portion 30 of the implant 3 will be able to smoothly disengage from the pusher 100 along the corresponding arcuate or linear section of the pusher 110 and/or locking member 120, and even in some cases, be able to disengage from the pusher 100 without having to have any sharp angle hooks to catch the first connecting portion 30 of the implant 3, and the implant 3 will be easily disengaged.

Specifically, referring to fig. 3 and 4, in the present embodiment, the pushing member 110 includes an elongated main body 112, a base 113 connected to a distal end of the main body 112, and a second connecting portion 114 connected to a distal end of the base 113. The proximal end of the body 112 is connected to the distal end of a handle (not shown) that is used to drive the body 112 (and thus the pusher 110) in motion.

The main body 112 is generally tubular, preferably 304 stainless steel, nitinol, or the like, and has a receiving cavity 115 therein. The base 113 is substantially cylindrical, and is preferably 304 stainless steel, nitinol, or the like, and has a guide hole 116 formed therein so as to extend therethrough, and the guide hole 116 communicates with the housing chamber 115. The second connecting portion 114 is substantially arc-shaped, and is preferably 304 stainless steel, nitinol, etc., for forming the first distal section 111. In other words, in this embodiment, the first distal section 111 is configured as an arcuate section 111 with an axial spacing between the distal end of the arcuate section 111 and the distal end of the base 113, and an opening 117 is formed therebetween.

The distal section of the locking member 120 is in the shape of a straight rod for forming the second distal section 121. In other words, in the present embodiment, the second distal section 121 is configured as a rod-shaped section 121. The proximal end of the locking member 120 is coupled to an operating member (not shown) for driving the locking member 120 to move axially (but not rotationally). As an example, the operation member may be screwed to the proximal end of the handle, and the locking member 120 may be driven to move axially by rotating the operation member relative to the handle.

In the locked state, as shown in fig. 3, the locking member 120 is partially received in the receiving cavity 115 and is movably inserted through the guide hole 116 of the base 113, and the rod-shaped section 121 thereof is connected with the distal end of the arc-shaped section 111 to form a closed loop structure 130, which can be achieved by manipulating the manipulating member to push the locking member 120 distally. At this time, the opening 117 between the base 113 and the distal end of the arc-shaped section 111 is closed, and the base 113, the rod-shaped section 121 and the arc-shaped section 111 together enclose a receiving space 118 for receiving the first connecting portion 30 of the implant 3.

As shown in fig. 4, in the unlocked state, the rod-shaped section 121 of the locking member 120 is separated from the arcuate section 111 to open the closed loop structure 130, which may be accomplished by manipulating the handle or the control member to push the pusher member 110 distally or to withdraw the locking member 120 proximally. At this time, the opening 117 between the base 113 and the distal end of the arc section 111 is open. The arc-shaped section 111 does not have a hook-shaped part with sharp corners for hooking the first connecting part 30 of the implant 3, so that the first connecting part 30 of the implant 3 can smoothly separate from the pushing device 100 along the arc-shaped section 111 through the open opening 117, and the implant 3 can be easily separated.

In this embodiment, to facilitate the installation of the locking member 120, the main body 112 and the base 113 are preferably designed to be separate. In assembly, the locking member 120 may be partially received in the receiving cavity 115 of the body 112, and then the distal end of the locking member 120 may be aligned with the guide hole 116 of the base 113 and passed through the base 113 via the guide hole 116, and then the body 112 and the base 113 may be fixedly connected by welding, crimping, bonding, or the like. It will be appreciated that in other embodiments, the body portion 112 and the base portion 113 may be integrally designed.

To enhance the connection strength of the base 113 with the second connecting portion 114/arc-shaped section 111, it is preferable that the base 113 is formed as a single piece with the second connecting portion 114/arc-shaped section 111, and it is more preferable that the outer peripheral wall of the base 113 is tangent to the proximal outer side wall of the second connecting portion 114/arc-shaped section 111. It will be appreciated that in other embodiments, the base 113 and the second connecting portion 114/arcuate section 111 may be separately configured and then fixedly attached together by welding, crimping, or bonding. It will also be appreciated that in other embodiments, the body portion 112, the base portion 113 and the second connecting portion 114/the arcuate section 111 may be integrally formed as a single piece to enhance the overall strength of the pushing member 110.

Referring to fig. 3 to 5, it is preferable that the start and end of the arc-shaped section 111 are located at the central axis L of the pushing member 110, respectively ₁ To provide sufficient receiving space 118 for the first connecting portion 30 of the implant 3. Further preferably, the arc-shaped section 111 has a circular arc shape, a central angle a formed between a start end and an end thereof is preferably in a range of 90 ° to 180 °, and an arc length h of the circular arc formed between the start end and the end thereof ₁ Preferably in the range of 2.5-5mm. Optionally, the radius of the arcuate section 111 is equal or substantially equal to the diameter of the base 113.

To increase the reliability of the connection of the arc-shaped section 111 to the rod-shaped section 121 and to prevent the implant 3 from accidentally falling out of the pushing device 100, the arc-shaped section 111 is preferably removably inserted into engagement with the rod-shaped section 121. Specifically, the distal end of the arcuate section 111 is provided with a socket 119. The socket 119 extends distally from the inner side of the arcuate section 111 proximate the base 113, preferably axially through the distal end of the arcuate section 111. It will be appreciated that in other embodiments, the plug aperture 119 may also be formed as a blind hole, i.e., not extending through the distal end of the arcuate section 111. In the locked state, the rod-shaped section 121 engages in a plug-in connection with the plug-in opening 119, so that a closed-loop structure 130 is formed. In the unlocked state, the rod-shaped section 121 is released from the plug aperture 119, thereby opening the closed-loop structure 130.

In order to facilitate the axial movement of the rod-shaped section 121 into the insertion hole 119 or the release from the insertion hole 119, it is preferable that the central axis of the insertion hole 119 coincides with the central axis of the rod-shaped section 121 and is parallel to the central axis L of the pushing member 110 ₁ . As previously described, since the mating holes 119 are provided at the distal end of the arcuate section 111, the distal end of the arcuate section 111 is offset from the central axis L of the pusher 110 ₁ Therefore, it is easy to understand that the central axis of the insertion hole 119 and the central axis of the rod-shaped section 121 are also offset from the central axis L of the pushing member 110 ₁ 。

It will be appreciated that in other embodiments, other connection means may be used for the arcuate section 111 and the rod section 121. For example, the insertion hole 119 may be omitted, and the rod-shaped section 121 may be directly abutted against the inner side of the arc-shaped section 111 near the base 113 to form a closed loop structure, or the rod-shaped section 121 may be abutted against any one of the side walls of the arc-shaped section 111 adjacent to the inner side thereof to form a closed loop structure.

Also preferably, the guide hole 116 of the base 13 includes a first guide hole 116A and a second guide hole 116B communicating with each other, wherein a central axis of the first guide hole 116A is parallel to a central axis L of the pusher 110 ₁ And is aligned with the insertion hole 119, the central axis of the second guide hole 116B is opposite to the central axis L of the pushing member 110 ₁ Inclined and in communication with the receiving cavity 115 of the body 112. It is further preferable that the central axis of the second guide hole 116B is opposite to the central axis L of the pushing member 110 ₁ Inclination angle W ₁ In the range of 15 DEG to 20 deg. The partial locking member 120 is inserted into the first guide hole 116A and the second guide hole 116B.

The second guide hole 116B is designed such that the proximal end of the locking member 120 can be centered with the handle, and a manipulation member for driving the locking member 120 can be rotatably coupled to the center of the handle; in addition, when the first connecting portion 30 of the implant 3 is released, after the locking member 120 is retracted or advanced to fully open the opening 117 between the base 113 and the distal end of the arcuate section 111, at least a portion of the locking member 120 remains positioned within the second guide hole 116B, thereby effectively preventing the locking member 120 from fully falling out into the receiving cavity 115 of the body portion 112, such that even if the implant 3 is not released to the target position or configuration requiring readjustment, the locking member 120 can be conveniently advanced distally again so that the locking member 120 follows the second guide hole 116B and the first guide hole 116A to engage the engagement hole 119 to again lock the first connecting portion 30 of the implant 3 to adjust the implant 3.

It will be appreciated that in other embodiments, the second guide bore 116B may be omitted, with only a guide bore extending axially through itself being provided in the base 113. In this case, a portion of the locking member 120 is received in the receiving cavity 115 of the body portion 112, and the distal end of the locking member 120 is inserted through the guide hole in the base portion 113 to engage with the insertion hole 119 to form a closed loop structure to lock the first connection portion of the implant 3. When it is desired to release the implant 3, the distal end of the locking member 120 is retracted into the guide bore by retracting the locking member 120 or pushing the pusher member 110 forward.

Preferably, in the present embodiment, the locking member 120 is made of an elastic material having an elastic modulus in the range of 60 to 120GPa, such as 304 stainless steel or nitinol, etc., so that the locking member 120 can be adaptively deformed to pass through the second guide hole 116B and the first guide hole 116A.

Referring to fig. 6, preferably, the locking member 120 is generally rod-shaped and gradually tapers from its proximal end to its distal end, i.e., the diameter of the locking member 120 gradually decreases from its proximal end to its distal end, in a natural state, i.e., without being constrained by an external force. Thus, the larger diameter proximal end of the locking member 120 can effectively increase the connection area with the manipulation member, while the smaller diameter distal end thereof allows the radial dimension of the base 113 to be smaller and more easily accommodate the deformation of the second guide bore 116B and the first guide bore 116A. Preferably, the locking member 120 is formed as a single piece. It will be appreciated that in other embodiments, as shown in fig. 7, the locking member 120' may be formed from a plurality of stepped sections of different diameters, and then joined by welding, crimping, riveting, or the like.

Referring to fig. 8 and 9, the present embodiment will be described taking the implant 3 as an inferior vena cava filter, the proximal end of which is provided with the first connecting portion 30. The first connection 30 is configured as a curved recovery hook. When the implant 3 is connected, the first connecting portion 30 of the implant 3 may be hooked on the second connecting portion 114/the arc-shaped section 111 of the pushing device 100, and then the locking member 120 is pushed distally, so that the locking member 120 penetrates out from the base 113 until being plugged into the plugging hole 119 to form the closed loop structure 130, at this time, the first connecting portion 30 of the implant 3 is firmly locked by the closed loop structure 130, thereby effectively preventing the implant 3 from falling off from the pushing device 100.

During delivery, the pusher 100 and implant 3 may be received within the sheath 4, and then the implant 3 may be delivered into the inferior vena cava via the left iliac vein, pushing the pusher 100 forward or withdrawing the sheath 4 causing the implant 3 to be released from within the sheath 4, the implant 3 self-expanding to its expanded configuration. After the implant 3 is adjusted to the target position, the locking member 120 or the forward pushing member 110 is retracted to open the closed loop structure 130, and then the pushing device 100 is retracted as a whole, at which time the first connecting portion 30 of the implant 3 gradually moves away from the base portion 113 along the arcuate section 111 until it is withdrawn from the opening 117, i.e., complete release of the implant 3 is completed.

Referring to fig. 10, it can be seen that the sheath 4 with the implant 3 and the pusher device 100 can also be delivered into the inferior vena cava via the right iliac vein, at which time, since the opening 117 is oriented toward the right iliac vein and the body portion 112 of the pusher 110 (located within the sheath 4) forms a curve at the intersection corresponding to the right iliac vein and the inferior vena cava, the curved section 111 will automatically deflect to the left under the action of the curve of the body portion 112, reducing contact between the first connecting portion 30 and the curved section 111, and the first connecting portion 30 will more easily fall out of the opening 117 than would be the case if the lower vena cava were accessed from the left iliac vein.

Referring to fig. 11 to 12, the pushing device 200 of the second embodiment of the present invention is the same as the pushing device 100 of the first embodiment, and is not described herein, and the main differences between the pushing device 200 of the second embodiment of the present invention and the pushing device 100 of the first embodiment are that: the first distal section 211 (i.e. the second connection 214) of the pushing member 210 of the present embodiment forms a rod-shaped section 211, and the second distal section 221 of the locking member 220 forms an arc-shaped section 221, wherein the rod-shaped section 211 and the arc-shaped section 221 are adapted to be in a plug-fit to form a closed loop structure 230.

Specifically, the pushing member 210 includes the main body 112, the base 113 connected to the distal end of the main body 112, and the second connecting portion 214 connected to the distal end of the base 113, wherein the main body 112 has the receiving cavity 115 therein, and the base 113 has the guide hole 116 therein.

Referring to fig. 12 to 15, the guide hole 116 also includes the first guide hole 116A and the second guide hole 116B communicating with each other, wherein a central axis of the first guide hole 116A is parallel to a central axis L of the pusher 210 ₁ The central axis of the second guide hole 116B is opposite to the central axis L of the pushing member 210 ₁ Inclined and in communication with the receiving chamber 115. The central axis of the second guide hole 116B is opposite to the central axis L of the pushing member 210 ₁ Inclination angle W ₂ And is also preferably in the range of 15 deg. to 20 deg.. The second connection 214/rod-shaped section 211 and the first guide hole 116A are both offset from the central axis L of the pusher 210 ₁ And are respectively positioned at the central axis L of the pushing member 210 ₁ Is provided.

The locking piece 220 is partially accommodated in the accommodation chamber 115 and passes through the second guide hole 116B and the first guide hole 116A. The distal end of the arcuate section 221 of the locking member 220 is formed with a mating hole 229 for mating with the rod section 211 to form a closed loop structure 230.

Preferably, referring to fig. 16 to 17, at least the arc-shaped section 221 of the locking member 220 is made of a shape memory material, more preferably a shape memory alloy having an elastic modulus of 60-120GPa, such as nickel-titanium alloy, and the arc-shaped section 221 has a predetermined shape (e.g., obtained by heat treatment) as shown in fig. 16 in a natural state (i.e., a state free from external force). In the pre-formed configuration, the end of the arc-shaped section 221 and the initial end of the arc-shaped section 221 are located at the central axis L of the straight rod-shaped proximal section 222 of the locking member 220 ₂ Is the same side of (a).

Thus, when the rod-shaped section 211 is released from the insertion hole 229 of the arc-shaped section 221 by withdrawing the pushing member 210 or pushing the locking member 220 forwardAfter release, the arcuate segment 221 is self-deforming to return to its pre-formed configuration, i.e., expands radially outwardly away from the central axis L of the pusher 210 ₁ Until the end of the arc-shaped section 221 and the starting end of the arc-shaped section 221 are positioned at the central axis L of the pushing member 210 ₁ At this point, the push device 200 may be withdrawn entirely such that the first connecting portion 30 of the implant 3 gradually moves away from the base 113 along the arcuate section 221 until completely out of the arcuate section 221, i.e., complete release of the implant 3 is completed. In this case, the arcuate segment 221 automatically expands radially outward so that its distal and initial ends are located at the central axis L of the pusher 210 ₁ The contact probability of the first connecting portion 30 of the implant 3 with the arc-shaped section 221 is made smaller, and thus, the first connecting portion 30 of the implant 3 is more easily released. Preferably, in the unlocked state, the distance between the end of the arc-shaped section 221 and the end of the rod-shaped section 211 is 1-2 times the diameter of the first connecting portion 30 of the implant 3, so that the end of the arc-shaped section 221 is not spread out too far to be recovered while ensuring that the first connecting portion 30 of the implant 3 can be smoothly released. It is noted that the diameter of the first connecting portion 30 of the implant 3 refers to the distance between two opposite side walls of the first connecting portion 30 between the first distal section 211 of the pushing member 210 and the second distal section 221 of the locking member, for example, in the case that the first connecting portion 30 is a hook or a loop formed by bending a metal rod, the diameter of the first connecting portion 30 is the diameter of the metal rod.

In particular, when the rod-shaped section 211 is released from the insertion hole 229 of the arc-shaped section 221 by withdrawing the pusher 210 or pushing the locking member 220 forward, the arc-shaped section 221 automatically expands radially outward, and at this time, the locking member 220 or pushing the pusher 210 forward may be withdrawn further to withdraw the arc-shaped section 221 into the guide hole 116. At this point, only the remaining rod-shaped section 211 is in contact with the first connection 30 of the implant 3, and the straight rod-shaped section 211 does not cause any obstruction to the movement of the first connection 30 of the implant 3 relative thereto, and the first connection 30 of the implant 3 is more easily released.

Also preferably, the locking member 220 further comprises a connecting portion for connecting the proximal end portion 222 thereof to the arcuate section 221, a connection section 223 of the housing. In the unlocked state, the connection section 223 drives the arc section 221 away from the central axis L of the pushing member 210 ₁ . Preferably, the locking member 220 is integrally formed of a shape memory material, more preferably a shape memory alloy having an elastic modulus of 60-120GPa, such as a nickel titanium alloy.

Further, in the natural state, the connecting section 223 is arc-shaped, more preferably arc-shaped, and is preferably tangential to the distal end of the proximal section 222, and the connecting section 223 gradually gets far from the central axis L of the pusher 210 from the proximal end thereof to the distal end thereof ₁ I.e. the line connecting each point on the section 223 with its corresponding centre point deviates from the centre axis L of the pusher 210 ₁ . The arc length h of the arc formed between the beginning and the end of the connecting section 223 ₂ Preferably 1.2-2.5mm. The central angle b formed between the beginning and the end of the connecting section 223 is preferably in the range of 40 ° to 90 °.

Further, in a natural state, the arc-shaped section 221 is driven by the connection section 223 to have its end more deviated from the central axis L of the pushing member 210 than its initial end ₁ . However, the connection line between each point on the arc section 221 and the corresponding center point is directed to the central axis L of the pushing member 210 ₁ . The proximal end of the arcuate section 221 is preferably tangential to the distal end of the connecting section 223. The arc length h of the arc formed between the start and end of the arc section 221 ₃ Preferably 2.5-5mm. The central angle c formed between the start and end of the arc-shaped section 221 is preferably in the range of 90 ° to 180 °.

Referring to fig. 18-20, the sheath 4 housing the push device 200 and implant 3 of the present embodiment, after delivery of the implant 3 into the inferior vena cava via the left iliac vein, pushing the push device 200 forward or withdrawing the sheath 4 causes the implant 3 to be released from within the sheath 4, the implant 3 self-expanding to its expanded configuration. When the implant 3 is adjusted to the target position, either the push member 210 or the push lock member 220 is retracted to open the closed loop structure 230, as shown in fig. 19, the arcuate segment 221 is now automatically radially outwardly expanded, at which point the push device 200 is retracted entirely to disengage the first connecting portion 30 of the implant 3, although it is preferable to further retract either the lock member 220 or the push member 210 such that the arcuate segment 221 is retracted into the guide bore 116, as shown in fig. 20. At this point, only the remaining rod-shaped section 211 is in contact with the first connecting portion 30 of the implant 3, and as previously described, the linear rod-shaped section 211 does not cause any obstruction to the movement of the first connecting portion 30 of the implant 3 relative thereto, and the first connecting portion 30 of the implant 3 is more easily released.

Referring to fig. 21 to 23, the pushing device 300 of the third embodiment of the present invention is the same as the pushing device 100 of the first embodiment, and is not described herein, and the pushing device 300 of the third embodiment of the present invention is mainly different from the pushing device 100 of the first embodiment in that: the second connection portion 314 (i.e. the first distal end section 311/the arc-shaped section 311) of the pushing member 310 of the present embodiment is made of a shape memory material, preferably a shape memory alloy with an elastic modulus of 60-120GPa, such as a nickel-titanium alloy, and the arc-shaped section 311 has a predetermined shape (e.g. obtained by heat treatment) in a natural state (i.e. a state free from external force), in which the end of the arc-shaped section 311 and the start end of the arc-shaped section 311 are located at the central axis L of the pushing member 310 ₁ Is the same side of (a).

Thus, when the rod-shaped section 121 is released from the insertion hole 119 of the arc-shaped section 311 by withdrawing the locking member 120 or pushing the pusher 310 forward, the arc-shaped section 311 is self-deformed to return to its pre-shaped configuration, i.e., expands radially outward away from the central axis L of the pusher 310 ₁ Until the tail end of the arc-shaped section 311 and the starting end of the arc-shaped section 311 are positioned at the central axis L of the pushing piece 310 ₁ At this point, the pusher 300 may be withdrawn entirely such that the first connecting portion 30 of the implant 3 gradually moves away from the base 113 along the arcuate section 311 until it is completely disengaged from the arcuate section 311, i.e., complete release of the implant 3 is completed. In this case, the arcuate segment 311 automatically expands radially outward so that its distal and initial ends are located at the central axis L of the pusher 310 ₁ The contact probability of the first connecting portion 30 of the implant 3 with the arc-shaped section 311 is made smaller, and thus, the first connecting portion 30 of the implant 3 is more easily released. Preferably, in the unlocked state, the end of the arcuate section 311 is in contact with the rod-shaped section121 is 1-2 times the diameter of the first connecting portion 30 of the implant 3 to ensure that the first connecting portion 30 of the implant 3 can be smoothly released.

In particular, when the rod-shaped section 121 is released from the insertion hole 119 of the arc-shaped section 311 by withdrawing the locking member 120 or pushing the pushing member 310 forward, the arc-shaped section 311 automatically expands radially outward, and at this time, the locking member 120 or pushing member 310 may be withdrawn further to withdraw the rod-shaped section 121 into the guide hole 116. At this time, only the arc-shaped section 311 is left with the possibility of coming into contact with the first connecting portion 30 of the implant 3, and the first connecting portion 30 of the implant 3 is more easily released. As shown in fig. 24, the guide hole 116 of the present embodiment also includes the first guide hole 116A and the second guide hole 116B communicating with each other as in the first embodiment, wherein the central axis of the first guide hole 116A is parallel to the central axis L of the pusher 110 ₁ The central axis of the second guide hole 116B is opposite to the central axis L of the pushing member 110 ₁ Inclined and in communication with the receiving chamber 115. The central axis of the second guide hole 116B is opposite to the central axis L of the pushing member 110 ₁ Inclination angle W ₃ And is also preferably in the range of 15 deg. to 20 deg..

Referring to fig. 23 and 24, it is also preferable that the pushing member 310 further includes a connection section 313 for connecting the base 113 and the arc-shaped section 311. In the unlocked state, the connection section 313 drives the arc-shaped section 311 away from the central axis L of the pushing member 310 ₁ . Preferably, the connection section 313 is also made of a shape memory material, more preferably a shape memory alloy with an elastic modulus of 60-120GPa, such as a nickel titanium alloy.

Further, in a natural state, the connection section 313 has an arc shape, more preferably, an arc shape, and the connection section 313 is gradually far from the central axis L of the pushing member 310 from the proximal end to the distal end thereof ₁ I.e. the line connecting the points on section 313 with their respective centers of circles deviates from the central axis L of pusher 310 ₁ . The arc length h of the arc formed between the beginning and the end of the connecting section 313 ₄ Preferably 1.2-2.5mm. The central angle d formed between the beginning and the end of the connecting section 313 is preferably in the range of 40 ° to 90 °.

Further, in a natural state, the arc-shaped section 311 is driven by the connection section 313 to make its end deviate from the central axis L of the pushing member 310 with respect to its initial end ₁ . However, the line connecting each point on the arc section 311 and its corresponding center point is directed to the central axis L of the pushing member 310 ₁ . The proximal end of the arcuate section 311 is preferably tangential to the distal end of the connecting section 313. The arc length h of the arc formed between the starting end and the tail end of the arc-shaped section 311 ₅ Preferably 2.5-5mm. The central angle e formed between the start and end of the arc-shaped section 311 is preferably in the range of 90 ° to 180 °.

Referring to fig. 25-27, the sheath 4 housing the pusher device 300 and implant 3 of the present embodiment, after delivery of the implant 3 into the inferior vena cava via the left iliac vein, pushing the pusher device 300 forward or withdrawing the sheath 4 causes the implant 3 to be released from within the sheath 4, the implant 3 self-expanding to its expanded configuration. After the implant 3 is adjusted to the target position, either the pusher 310 is pushed forward or the lock 120 is withdrawn to open the closed loop structure 130. As shown in fig. 26, the arcuate section 311 automatically expands radially outwardly at which point the pusher 300 is withdrawn entirely to disengage the first connector 30 of the implant 3, but the locking member 120 or the forward pusher 310 is preferably withdrawn further to retract the rod-like section 121 into the guide bore 116. As shown in fig. 27, in this case, only the arc-shaped section 311 has the possibility of coming into contact with the first connecting portion 30 of the implant 3, and the pushing device 300 is then retracted as a whole, so that the first connecting portion 30 of the implant 3 can be gradually moved away from the base 113 without any obstruction (i.e. in the case where the first connecting portion 30 of the implant 3 is not in contact with the arc-shaped section 311, for example, when the arc-shaped section 311 automatically expands radially outwards to have a radial distance between its distal end and the first connecting portion 30), or smoothly along the arc-shaped section 311 (in the case where the first connecting portion 30 of the implant 3 comes into contact with the arc-shaped section 311, for example, when the arc-shaped section 311 automatically expands radially outwards but there is no radial distance between its distal end and the first connecting portion 30), the release of the implant 3 is easier until it is released from the arc-shaped section 311.

The above description is merely of a preferred embodiment of the present invention, the protection scope of the present invention is not limited to the above-listed examples, and any simple changes or equivalent substitutions of the technical solutions that can be obviously obtained by those skilled in the art within the technical scope of the present invention disclosed in the present invention fall within the protection scope of the present invention.

Claims

1. A pushing device for pushing an implant to a target position and releasing the implant at the target position, the implant being provided with a first connection at its proximal end for detachable connection with the pushing device, characterized in that the pushing device comprises a pushing member and a locking member, and that the pushing member and the locking member are axially movable relative to each other for switching the pushing device between a locked state and an unlocked state; in the locked state, the first distal section of the pusher and the second distal section of the locking member cooperate to form a closed loop structure to lock the first connection of the implant; in the unlocked state, the closed loop structure is opened to release the first connection of the implant.

2. The pushing device of claim 1, wherein the pushing member comprises a main body portion having a receiving cavity therein, a base portion connected to a distal end of the main body portion, and a second connecting portion connected to a distal end of the base portion, the second connecting portion having the first distal end section, and wherein in the locked state the locking member is received in the receiving cavity and passes through the base portion to connect with the second connecting portion.

3. The pusher of claim 1, wherein in the locked state one of the first distal section of the pusher and the second distal section of the locking member is an arcuate section and the other of the first distal section of the pusher and the second distal section of the locking member is a rod-shaped section, the arcuate section and the rod-shaped section collectively enclosing the closed loop structure.

4. A pushing device according to claim 3, wherein in the locked state, the start and end of the arcuate segment are located on opposite sides of the central axis of the pushing member, respectively, and a central angle formed between the start and end of the arcuate segment is in the range of 90 ° to 180 °.

5. A pushing device according to claim 3, wherein the arcuate section has a socket therein; in the locking state, the rod-shaped section is in plug-in fit with the plug-in hole so as to form the closed-loop structure; in the unlocked state, the rod-shaped section is released from the socket hole to open the closed-loop structure.

6. The pushing device of claim 5, wherein the central axis of the insertion hole coincides with the central axis of the rod-shaped section and is parallel to and offset from the central axis of the pushing member.

7. The pusher of claim 5, wherein a first guide aperture is provided in the pusher, the central axis of the first guide aperture being parallel to the central axis of the pusher, and wherein in the locked state a portion of the locking member is disposed through the first guide aperture.

8. The pusher of claim 7, wherein a second guide aperture is further provided in the pusher, the central axis of the second guide aperture being inclined relative to the central axis of the pusher, and the distal end of the second guide aperture being in communication with the proximal end of the first guide aperture, a portion of the locking element being disposed through the second guide aperture and the first guide aperture in the locked condition.

9. The pushing device of claim 8, wherein the locking member is made of an elastic material having an elastic modulus in the range of 60-120GPa such that the locking member is adaptively deformable to pass through the second guide hole and the first guide hole.

10. The pushing device of claim 8, wherein the locking element is generally rod-shaped in nature and the diameter of the locking element decreases from the proximal end of the locking element to the distal end of the locking element.

11. A pushing device according to any of claims 3-10, wherein the arc-shaped section is made of a shape memory material, which in the unlocked state is self-deforming away from the central axis of the pushing member until the end of the arc-shaped section is on the same side of the central axis of the pushing member as the start end of the arc-shaped section.

12. The pusher of claim 11, wherein a connecting section is attached to a proximal end of the arcuate section, the connecting section being made of a shape memory material, the connecting section driving the arcuate section away from a central axis of the pusher in the unlocked state.

13. The pushing device of claim 12, wherein the connecting section is arcuate in nature and the connecting section tapers away from the central axis of the pushing member from its proximal end to its distal end, the connecting section having a central angle between its beginning and its end in the range of 40 ° to 90 °.

14. A delivery device comprising a sheath having a lumen and a pushing device according to any one of claims 1 to 13, the pushing device being movably received within the lumen of the sheath.

15. A delivery system comprising the delivery device of claim 14 and the implant, the implant having a compressed configuration received within the lumen of the sheath and an expanded configuration released from the lumen of the sheath.