CN117159784A - Liquid band-aid for repairing wound surface difficult to heal, and preparation method and application thereof - Google Patents
Liquid band-aid for repairing wound surface difficult to heal, and preparation method and application thereof Download PDFInfo
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- CN117159784A CN117159784A CN202310342662.6A CN202310342662A CN117159784A CN 117159784 A CN117159784 A CN 117159784A CN 202310342662 A CN202310342662 A CN 202310342662A CN 117159784 A CN117159784 A CN 117159784A
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- aid
- healing
- liquid band
- difficult
- wound
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- 239000007788 liquid Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 206010052428 Wound Diseases 0.000 claims abstract description 55
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 55
- 239000000645 desinfectant Substances 0.000 claims abstract description 18
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 12
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract description 11
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract description 11
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract description 11
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims description 18
- 230000035876 healing Effects 0.000 claims description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 12
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 8
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 8
- 239000013003 healing agent Substances 0.000 claims description 8
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 8
- 239000004014 plasticizer Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 8
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- 229940072049 amyl acetate Drugs 0.000 claims description 6
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 claims description 6
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- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 claims description 5
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 5
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 claims description 5
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- 230000037314 wound repair Effects 0.000 claims description 3
- YTUUEOBZXXUZJL-UHFFFAOYSA-N 2,3-diethylpentane-1,2,3-triol Chemical compound CCC(O)(CC)C(O)(CC)CO YTUUEOBZXXUZJL-UHFFFAOYSA-N 0.000 claims description 2
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 2
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- 239000008055 phosphate buffer solution Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
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- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
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- 238000010586 diagram Methods 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
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- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
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- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
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- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
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- 238000005562 fading Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses a liquid band-aid for repairing a wound difficult to heal, and a preparation method and application thereof, and belongs to the technical field of medical dressing. The liquid band-aid achieves the aim of long-acting antibiosis by means of the combined disinfection mode of the octenidine hydrochloride and the phenoxyethanol; the cell factor is compounded by the disinfectant, so that the antibacterial effect is realized, and the cell factor can continuously and effectively play a role in promoting wound healing; the ethyl cellulose is used as a film forming material, has the advantages of high film forming speed, ventilation, water resistance, no viscosity, safe production and the like, and can form lasting protection on wound surfaces; meanwhile, the adhesive bandage can be directly sprayed on the wound surface, thereby preventing cross infection caused by repeated use. The liquid band-aid product for repairing the wound surface difficult to heal has good sterilization and bacteriostasis property and air permeability, and has the advantages of short film forming time, good film forming effect and strong adhesion.
Description
Technical Field
The invention belongs to the technical field of medical dressing, and particularly relates to a liquid band-aid for repairing a wound surface difficult to heal, and a preparation method and application thereof.
Background
The wound surface difficult to heal is also called refractory wound surface and chronic wound surface. The difficult-to-heal wound surface formation mechanism is complex and often caused by multiple factors. Including the formation of bacterial biofilms, decreased cytokine secretion, and other clinical conditions.
The bacterial biological membrane is a membranous structure formed by embedding bacteria and products thereof, necrotic tissues, extracellular matrixes and the like in a wound surface. Once formed, bacterial biofilms greatly inhibit wound healing. Therefore, the bacterial biological film which timely damages and eliminates the surface of the wound surface has positive effect on the healing of the wound surface which is difficult to heal.
Cytokines are secreted by immune cells, platelets, tissue cells, etc., and are involved in wound repair by mediating cell-cell or cell-matrix interactions through binding to cell-specific membrane receptors. The research shows that the content of a plurality of growth factors such as basic fibroblast growth factor, vascular endothelial cell growth factor, transforming growth factor-beta, epidermal growth factor and the like in chronic wound tissues is reduced or the function is impaired.
Through researches of scholars, the most main cause of the wound surface deterioration is wound surface bacterial infection. In clinical medicine, most used debridement disinfectants comprise alcohol disinfectants, guanidine disinfectants, quaternary ammonium salt disinfectants and the like, the alcohol disinfectants cannot play a role in sterilizing for a long time, and the guanidine disinfectants and the quaternary ammonium salt disinfectants are interfered by wound surface secretions and have poor sterilization effect, so that good debridement and sterilization effects cannot be achieved, and the healing promotion effect of the medicines is difficult to play in the treatment process. Meanwhile, the product is airtight, and the product is easy to adhere to the wound, so that the problems of difficult dressing change, repeated tearing of the wound and the like are caused.
The existing liquid adhesive bandage products are generally difficult to continuously and effectively disinfect wound surfaces difficult to heal, cannot achieve the effect of promoting wound healing, and have the problem of difficult product replacement.
Disclosure of Invention
The first object of the invention is to provide a liquid band-aid for repairing difficult-to-heal wound surface, which is sterilized by the combination of octenidine hydrochloride and phenoxyethanol; compounding cell factors with disinfectant; the ethyl cellulose is used as a film forming material for combination, so that the band-aid has long-acting antibacterial effect and can continuously promote wound healing on the premise of promoting the healing function of the wound surface difficult to heal, and the band-aid is safe and effective.
The second object of the invention is to provide a liquid band-aid for repairing a wound surface difficult to heal, which is prepared into a liquid dosage form, ensures that products can be directly sprayed on the wound surface, prevents cross infection caused by repeated use and the like, and solves the technical problem that the conventional products are inconvenient to replace.
The third object of the invention is to provide a preparation method of the liquid band-aid for repairing the wound surface difficult to heal, which has simple and effective operation flow and is convenient for mass production.
The invention is realized by the following technical scheme:
the liquid band-aid for repairing the wound surface difficult to heal is mainly prepared from the following raw materials in parts by weight:
2-15 parts of film forming agent, 0.1-6 parts of disinfectant, 0.5-4 parts of plasticizer, 0.8-10 parts of wetting agent, 0.0001-0.01 part of healing agent and 65-95 parts of solvent;
the film forming agent is ethyl cellulose;
the disinfectant is a mixture of octenidine hydrochloride and phenoxyethanol;
the plasticizer comprises one or more of isopropyl palmitate, tri-n-butyl citrate, ethyl oleate and triethyl citrate;
the wetting agent is a mixture of a wetting raw material and a buffer solution;
the healing agent is a cytokine;
the solvent includes one or more of ethyl acetate, butyl acetate, amyl acetate, hexamethyldisiloxane and isooctane.
Preferably, the viscosity of the ethylcellulose is 6-8mpa·s.
The above settings for the viscosity of the selected film former are based on viscosity representing molecular weight, which is too small or too large to form a film.
Preferably, the mixing mass ratio of the octenidine hydrochloride to the phenoxyethanol in the disinfectant is 1:10-1:20.
Preferably, the plasticizer is isopropyl palmitate and/or triethyl citrate.
Preferably, the wetting raw material comprises one or more of triethyl glycerol, triethanolamine and polyethylene glycol;
the mixing mass ratio of the wetting raw materials to the buffer solution is 1:2-5:1;
the buffer solution is phosphate buffer solution, and the pH value is 6.8-7.8.
Preferably, the cytokines include one or more combinations of Vascular Endothelial Growth Factor (VEGF), nerve Growth Factor (NGF), basic fibroblast growth factor (bFGF) and transforming growth factor-beta (TGF-beta).
A preparation method of a liquid band-aid for repairing a wound surface difficult to heal comprises the following steps:
s1: selecting a plasticizer and a solvent according to the corresponding parts by weight, stirring and mixing uniformly, adding a film forming agent and a disinfectant, mixing and homogenizing to emulsify to obtain a standby liquid I;
s2: and selecting a healing agent and a wetting agent according to the corresponding parts by weight, stirring at 2-8 ℃ until the healing agent and the wetting agent are dissolved, adding the standby liquid I, and uniformly mixing to obtain a finished product.
The application of the liquid band-aid for repairing the wound surface difficult to heal comprises the application of the liquid band-aid in preparing medical dressing products.
Compared with the prior art, the invention has at least the following technical effects:
the invention provides a liquid band-aid for repairing a wound surface difficult to heal, which has excellent disinfection effect by combining octenidine hydrochloride and phenoxyethanol, and the disinfection components can be released slowly, at a uniform speed and for a long time, so that the aim of long-acting antibiosis can be fulfilled; the cell factor is compounded by the disinfectant, so that the antibacterial effect is realized, and the cell factor can continuously and effectively play a role in promoting wound healing; the ethyl cellulose is used as a film forming material, has the advantages of high film forming speed, ventilation, water resistance, no viscosity, safe production and the like, and can form lasting protection on wound surfaces; meanwhile, the adhesive bandage can be directly sprayed on the wound surface, thereby preventing cross infection caused by repeated use.
The liquid band-aid product for repairing the wound surface difficult to heal has good long-acting antibacterial effect, can continuously and effectively play a role in promoting wound healing, and has good practical value and popularization and application significance because the related preparation method is mature.
Drawings
FIG. 1 is a color display diagram of each test sample before flushing in a waterproof test;
fig. 2 is a color display diagram of each test sample after washing in the waterproof test.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the following examples, which are to be construed as merely illustrative and not limitative of the scope of the invention, but are not intended to limit the scope of the invention to the specific conditions set forth in the examples, either as conventional or manufacturer-suggested, nor are reagents or apparatus employed to identify manufacturers as conventional products available for commercial purchase.
Example 1:
the liquid band-aid for repairing the wound surface difficult to heal is prepared by the following steps:
s1: after stirring and mixing 30 g of ethyl acetate, 20 g of butyl acetate, 29 g of amyl acetate, 0.5 g of isopropyl palmitate and 0.5 g of triethyl citrate uniformly, adding 0.008 g of octenidine hydrochloride, 2.5 g of phenoxyethanol and 10 g of ethyl cellulose, mixing, homogenizing and emulsifying to obtain a standby liquid I;
s2: mixing 2 g of triethyl glycerate with 1.5 g of phosphate buffer, adding 0.0005 g of VEGF, 0.0005 g of NGF, 0.0005 g of bFGF and 0.0005 g of TGF-beta, stirring at 2-8 ℃ until the mixture is dissolved, adding standby liquid I, and uniformly mixing at 2-8 ℃ to obtain a finished product.
Example 2:
the liquid band-aid for repairing the wound surface difficult to heal is prepared by the following steps:
s1: after 65 g of ethyl acetate, 2 5 g of isooctane, 8 g of butyl acetate, 8 g of amyl acetate, 3.0 g of isopropyl palmitate and 0.2 g of tri-n-butyl citrate are stirred and mixed uniformly, 0.12 g of octenidine hydrochloride, 2.4 g of phenoxyethanol and 6 g of ethyl cellulose are added, and the mixture is mixed, homogenized and emulsified to obtain a standby liquid I;
s2: 1.0 g of triethyl glycerate is mixed with 0.5 g of phosphate buffer, 0.0005 g of VEGF and 0.0008 g of TGF-beta are added, stirring is carried out at 2-8 ℃ until the mixture is dissolved, and standby liquid I is added, and the mixture is uniformly mixed at 2-8 ℃ to obtain a finished product.
Example 3:
the liquid band-aid for repairing the wound surface difficult to heal is prepared by the following steps:
s1: 50 g of hexamethyldisiloxane, 10 g of isooctane, 10 g of butyl acetate, 10 g of amyl acetate, 3.0 g of isopropyl palmitate and 0.2 g of tri-n-butyl citrate are stirred and mixed uniformly, and then 0.1 g of octenidine hydrochloride, 2 g of phenoxyethanol and 12 g of ethyl cellulose are added, mixed, homogenized and emulsified to obtain a standby liquid I;
s2: mixing 4.0 g of triethyl glycerate with 4.0 g of phosphate buffer, adding 0.0006 g of VEGF and 0.008 g of TGF-beta, stirring at 2-8 ℃ until the mixture is dissolved, adding standby liquid I, and uniformly mixing at 2-8 ℃ to obtain a finished product.
Example 4:
the liquid band-aid for repairing the wound surface difficult to heal is prepared by the following steps:
s1: 50 g of hexamethyldisiloxane, 10 g of isooctane, 10 g of butyl acetate, 10 g of amyl acetate, 3.0 g of isopropyl palmitate and 0.2 g of tri-n-butyl citrate are stirred and mixed uniformly, and then 0.1 g of octenidine hydrochloride, 2 g of phenoxyethanol and 12 g of ethyl cellulose are added, mixed, homogenized and emulsified to obtain a standby liquid I;
s2: mixing 4.0 g of triethyl glycerate with 4.0 g of phosphate buffer, adding 0.0006 g of VEGF and 0.008 g of TGF-beta, stirring at 2-8 ℃ until the mixture is dissolved, adding standby liquid I, and uniformly mixing at 2-8 ℃ to obtain a finished product.
Comparative example 1
Unlike example 2, the following is: the comparative example does not contain phenoxyethanol. The procedure is as in example 2.
Comparative example 2
Unlike example 2, the following is: this comparative example does not contain cytokines. The procedure is as in example 2.
And (3) experimental verification:
1. antibacterial test
Analysis of antibacterial properties was performed on example 1, example 2, example 3, comparative example 1 and comparative example 2.
Coli, staphylococcus aureus and pseudomonas aeruginosa are three bacteria commonly found on wound surfaces, and thus the liquid wound dressings of example 1, example 2, example 3, comparative example 1 and comparative example 2 were mainly examined for bacteriostasis against the above three bacteria.
The antibacterial effect of the liquid dressing is judged according to the size of the antibacterial zone, the experimental thallus is cultivated by a conventional method in the field, and the experimental result is shown in table 1.
TABLE 1 bacteriostasis of three bacteria
| Coli bacterium | Staphylococcus aureus | Pseudomonas aeruginosa | |
| Example 1 | 19.67cm | 16.22cm | 11.82cm |
| Example 2 | 21.35cm | 17.91cm | 11.05cm |
| Example 3 | 18.67cm | 14.95cm | 10.36cm |
| Comparative example 1 | 15.49cm | 13.49cm | 9.63cm |
| Comparative example 2 | 20.05cm | 17.04cm | 12.48cm |
The results show that: examples 1, 2 and 3 all had bacteriostasis to E.coli, staphylococcus aureus and Pseudomonas aeruginosa and the bacteriostasis was significantly better than that of comparative example 1.
2. Wound healing test
Analysis of conditions of difficult wound surface promotion healing was performed on example 1, example 2, example 3, comparative example 1 and comparative example 2.
After the rat diabetes model is successfully manufactured by adopting streptozotocin, the defect wound surface is formed on the back skin of the animal, and the area is about 5cm 2 The method comprises the steps of carrying out a first treatment on the surface of the And E.coli, staphylococcus aureus and pseudomonas aeruginosa mixed bacteria liquid are injected at the wound surface to form the wound surface difficult to heal.
The liquid wound dressings of example 1, example 2, example 3, comparative example 1 and comparative example 2 were mainly examined for analysis of the healing promoting effect on difficult-to-heal wounds. After the wound surface is washed by sterile normal saline, the wound surface is wiped by sterile gauze, the liquid wound adhesives of the example 1, the example 2, the example 3, the comparative example 1 and the comparative example 2 are sprayed every 72 hours, the healing condition of the wound surface animal is observed for 7 days and 14 days, the healing rate is calculated by using imageJ, and the healing result is shown in the table 2 below.
Table 2 wound healing test
The results show that the healing promoting effect of the examples 1, 2 and 3 on difficult wound surfaces is obviously better than that of the comparative example 2.
3. Water vapor transmission test
The water vapor transmission rate test was performed for example 1, example 2, and example 3, and the test results are shown in table 3.
TABLE 3 Water vapor Transmission test
| Test item | Water vapor transmission rate g.m -2 .24h -1 | Film formation time s |
| Example 1 | 589 | 35 |
| Example 2 | 632 | 43 |
| Example 3 | 548 | 36 |
The results show that: the difference in water vapor transmission rate was not significant for each example. The water vapor transmission rate of each example was significantly higher than industry standard 300g.m -2 .24h -1 。
4. Film Forming time test
Film formation time tests were performed on examples 1, 2 and 3.
The liquid wound dressings of example 1, example 2 and example 3 were sprayed 2 times on a die having a diameter of 2.7cm to 3.0cm (the die was first conditioned in an oven at 35 ℃ to 37 ℃ for 30 minutes), the above samples were placed at a temperature of 35 ℃ to 37 ℃ and a humidity of 45% -65% to start timing, and film formation times were observed, and the results are shown in Table 3.
The results showed that the film formation time did not exceed 1min.
5. Waterproof test
Waterproof performance tests were performed on examples 1, 2, and 3. 4 squares with the size of 2cm multiplied by 4cm are marked on the waterproof paper, water-soluble pigments are respectively smeared, 3 water-soluble pigments are respectively sprayed in the examples 1, 2 and 3 after the water-soluble pigments are dried, the rest areas are not treated, the water-soluble pigments are washed with water after film formation, and whether the color drops or not is observed.
As shown in FIG. 1, the color of each experimental sample before washing is shown.
As shown in FIG. 2, the color of each experimental sample after washing is shown.
The results show that: the color of the blank group after washing is obviously diluted without fading or dropping before and after washing in the examples 1, 2 and 3, and the results show that each example has waterproof performance.
In conclusion, the liquid wound plaster for promoting wound healing has the advantages of high film forming speed, ventilation, water resistance, no viscosity, safe production and the like, and has excellent antibacterial property and wound healing promoting effect.
Finally, it should be noted that: the foregoing description is only of the preferred embodiments of the invention and is not intended to limit the scope of the invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The liquid band-aid for repairing the wound surface difficult to heal is characterized by being prepared from the following raw materials in parts by weight:
2-15 parts of film forming agent, 0.1-6 parts of disinfectant, 0.5-4 parts of plasticizer, 0.8-10 parts of wetting agent, 0.0001-0.01 part of healing agent and 65-95 parts of solvent;
the film forming agent is ethyl cellulose;
the disinfectant is a mixture of octenidine hydrochloride and phenoxyethanol;
the plasticizer comprises one or more of isopropyl palmitate, tri-n-butyl citrate, ethyl oleate and triethyl citrate;
the wetting agent is a mixture of a wetting raw material and a buffer solution;
the healing agent is a cytokine;
the solvent includes one or more of ethyl acetate, butyl acetate, amyl acetate, hexamethyldisiloxane and isooctane.
2. The liquid band-aid for healing difficult wound repair according to claim 1, wherein the viscosity of the ethyl cellulose is 6-8 mPa-s.
3. The liquid band-aid for healing wound repair according to claim 1, wherein the mixing mass ratio of the octenidine hydrochloride and the phenoxyethanol in the disinfectant is 1:10-1:20.
4. A liquid band-aid for healing difficult wounds according to claim 1, wherein the plasticizer is isopropyl palmitate and/or triethyl citrate.
5. The liquid band-aid for healing a difficult wound according to claim 1, wherein the wetting raw material comprises one or more of triethyl glycerol, triethanolamine and polyethylene glycol;
the mixing mass ratio of the wetting raw materials to the buffer solution is 1:2-5:1;
the buffer solution is phosphate buffer solution, and the pH value is 6.8-7.8.
6. The liquid band-aid of claim 1, wherein the cytokines comprise one or more of vascular endothelial growth factor, nerve growth factor, basic fibroblast growth factor and transforming growth factor- β.
7. A method of preparing a liquid band-aid for healing of difficult to heal wounds according to any of claims 1 to 6, comprising the steps of:
s1: selecting a plasticizer and a solvent according to the corresponding parts by weight, stirring and mixing uniformly, adding a film forming agent and a disinfectant, mixing and homogenizing to emulsify to obtain a standby liquid I;
s2: and selecting a healing agent and a wetting agent according to the corresponding parts by weight, stirring at 2-8 ℃ until the healing agent and the wetting agent are dissolved, adding the standby liquid I, and uniformly mixing to obtain a finished product.
8. Use of a liquid band-aid for healing difficult wounds, comprising the use of a liquid band-aid according to any one of claims 1 to 6 in the manufacture of a medical dressing product.
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| EP0411315A1 (en) * | 1989-08-02 | 1991-02-06 | SchàLke & Mayr Gmbh | Aqueous antiseptic composition |
| CN102209542A (en) * | 2008-11-14 | 2011-10-05 | 阿尔塔控股股份公司 | Octenidine composition |
| CN110478518A (en) * | 2012-06-22 | 2019-11-22 | Z-医疗有限责任公司 | Hemostasis device |
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