CN117158916A - Vascular intervention medical device, vascular intervention medical system and application of vascular intervention medical device - Google Patents
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses a vascular intervention medical device, a vascular intervention medical system and application thereof, wherein the vascular intervention medical device comprises a main body frame, an electric signal transmission assembly and an electromagnetic shielding piece; the main body frame is an elastic supporting frame; the electric signal transmission assembly is arranged on the main body frame and comprises an electrode and a wire which are electrically connected; the electromagnetic shield is configured to reduce or block interference of external electromagnetic signals with electrical signals transmitted by the electrical signal transmission assembly. The electromagnetic shielding piece is arranged, so that interference of external electromagnetic signals on electric signals transmitted by the electric signal transmission assembly can be reduced or blocked, and the electric signal transmission accuracy of the vascular intervention medical device can be improved.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a vascular intervention medical device, a vascular intervention medical system and application of the vascular intervention medical device.
Background
Each organ of the human body has arterial blood supply, supplies oxygen and nutrients to tissues, and then flows back to the heart (atrium) through veins. If arterial stenosis is caused by various reasons to a certain extent, ischemia and hypoxia of tissues and organs can occur, and even tissue reconstruction, injury and necrosis occur, so that ischemic diseases of various organs (such as coronary artery ischemia and coronary heart disease) are caused. In recent years, with technical improvement, method improvement, and continuous improvement of software, hardware and equipment, vascular interventional diagnosis and treatment are becoming an important means in the medical field. Including coronary heart disease intervention diagnosis and treatment, renal artery intervention diagnosis and treatment, carotid artery intervention diagnosis and treatment, aortic intervention diagnosis and treatment, upper and lower limb artery intervention diagnosis and treatment, etc. The existing vascular interventional medical device generally comprises a built-in bracket, an electrode plate is fixed on the built-in bracket, then a thin wire is connected to the electrode plate in a resistance welding mode and led out to a telemetry circuit, and therefore transmission of electric signals between an intravascular circuit and an external circuit is achieved, and detection of relevant health information is achieved. However, since the interventional medical device needs to be intervened in a blood vessel, the size design is smaller, the conducted electric signals are generally weak and are easily interfered by external electromagnetic signals, so that the signal transmission accuracy is affected.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the invention proposes a vascular interventional medical device, a system and applications thereof.
In a first aspect of the invention, a vascular interventional medical device is presented, comprising:
the main body frame is an elastic supporting frame;
the electric signal transmission assembly is arranged on the main body frame and comprises an electrode and a wire, and the wire is electrically connected with the electrode;
an electromagnetic shield configured to reduce or block interference of external electromagnetic signals with electrical signals transmitted by the electrical signal transmission assembly.
According to the vascular intervention medical device provided by the embodiment of the invention, the vascular intervention medical device has at least the following beneficial effects: according to the vascular intervention medical device, the electromagnetic shielding piece is further configured on the basis of the electric signal transmission assembly comprising the electrode and the lead wire is arranged on the elastic main body frame, so that the interference of external electromagnetic signals on electric signals transmitted by the electric signal transmission assembly is reduced or blocked through the electromagnetic shielding piece, and the electric signal transmission accuracy of the vascular intervention medical device can be improved.
In some embodiments of the invention, the electromagnetic shield is provided on at least one side of the electrical signal transmission assembly.
In some embodiments of the invention, the electromagnetic shield is disposed on a side of the electrical signal transmission assembly facing away from the main body frame, covering the wires and exposing at least a portion of the electrodes.
In some embodiments of the invention, the electromagnetic shield is disposed between the electrical signal transmission assembly and the body frame.
In some embodiments of the invention, the electromagnetic shield is disposed between the electrical signal transmission assembly and the body frame, and on a side of the electrical signal transmission assembly facing away from the body frame, covering the wires and exposing at least a portion of the electrodes.
In some embodiments of the invention, the electromagnetic shield is disposed around the electrical signal transmission assembly and exposes at least a portion of the electrode.
In some embodiments of the invention, an insulating layer is provided between the electromagnetic shield and the electrical signal transmission assembly.
In some embodiments of the invention, the electromagnetic shield is any one of a metal shield layer, a carbon nanotube shield layer, a ferrite shield layer, a graphene shield layer; preferably, the material of the metal shielding layer is at least one selected from platinum and gold.
In some embodiments of the present invention, the material of the insulating layer is at least one selected from polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole, and SU 8.
In some embodiments of the invention, the electrical signal transmission assembly is configured from a layer of conductive material.
In some embodiments of the invention, the electrode and the lead are in a unitary structure.
In some embodiments of the invention, the conductive material layer is a composite layer of a metallic material layer, a non-metallic conductive material layer, or a non-metallic conductive material layer and a metallic material layer.
In some embodiments of the present invention, the conductive material layer includes a non-noble metal conductive base layer provided on a surface of the main body frame, and a noble metal protective layer covering the non-noble metal conductive base layer; the noble metal protection layer is made of at least one of platinum and gold.
In some embodiments of the invention, the layer of conductive material has a thickness of less than 5 μm.
In some embodiments of the invention, the body frame is configured to be retractable and expandable along a central axis.
In some embodiments of the invention, the body frame is hollow tubular.
In some embodiments of the invention, the side walls of the main body frame are in a mesh structure.
In some embodiments of the invention, the electrodes are provided at intersections of a mesh structure on the body frame.
In some embodiments of the invention, the electrodes are two or more.
In some embodiments of the invention, the electrodes are uniformly disposed along the radial and/or axial direction of the body frame.
In some embodiments of the present invention, the surface of the electrode is provided with a modification layer, the modification layer has a biological signal recognition function, and is used for recognizing and detecting the change of the biological signal in the blood vessel, and converting the change of the biological signal into a readable electric signal through the electrode and transmitting the readable electric signal to an external circuit; the biological signal comprises a chemical signal and/or a physical signal related to a physiological condition of the organism.
In some embodiments of the invention, the material of the modification layer is selected from at least one of an enzyme, a redox mediator, a nanomaterial, an antibody, biotin, a aptamer, a polymer, an ionophore, a piezoelectric material.
In some embodiments of the invention, the enzyme is selected from at least one of an oxidoreductase, a transferase, a hydrolase, a lyase, a ligase, an isomerase.
In some embodiments of the invention, the oxidoreductase is selected from the group consisting of glucose oxidase, glutamate oxidase, ethanol oxidase, lactate oxidase, amino acid oxidase, cholesterol oxidase, choline oxidase, nicotinamide adenine dinucleotide phosphate oxidase, oxalate oxidase, cytochrome oxidase, bilirubin oxidase, serotonin, galactose oxidase, glucose dehydrogenase, lactate dehydrogenase, ethanol dehydrogenase, aldehyde dehydrogenase, glutamate dehydrogenase, pyruvate dehydrogenase, sorbitol dehydrogenase, formate dehydrogenase, cellobiose dehydrogenase, amino acid dehydrogenase, succinate dehydrogenase, catalase, horseradish peroxidase, lactoperoxidase, glutathione peroxidase, ascorbate peroxidase, soybean peroxidase, cytochrome peroxidase, thyroid peroxidase, myeloperoxidase, superoxide dismutase, haloperoxidase, thiol peroxidase, 5α reductase, 5β reductase, aldehyde reductase, aldose reductase, hydroxymethylglutarate monoacyl-CoA reductase, methemoglobin reductase, nucleotide reductase, nitroreductase, thioreductase, dioxygenase, dihydrox reductase, oxygenol reductase, and oxygenol reductase.
In some embodiments of the invention, the transferase is selected from at least one of glutathione transferase, acetyl transferase, methyl transferase, transketolase, transaldolase, glycosyltransferase, transketolase, amino acid transferase, acyl transferase.
In some embodiments of the invention, the hydrolase is selected from at least one of a lipohydrolase, a phosphohydrolase, a glycoside hydrolase, an acetyl hydrolase, a nucleotide hydrolase, a helicase, a peptide hydrolase, a urease, a creatinine deiminase.
In some embodiments of the invention, the lyase is selected from at least one of a decarboxylase, a dehydrogenase, a dehalogenase, an aspartate ammonia lyase, a cysteine desulphurase.
In some embodiments of the invention, the ligase is selected from at least one of tRNA synthetase, succinylase A synthetase, amino acid ligase, DNA ligase, RNA ligase, carboxylase.
In some embodiments of the invention, the isomerase is selected from at least one of racemase, epimerase, mutase.
In some embodiments of the present invention, the nanomaterial is selected from at least one of a metal nanomaterial, a nanoceramic, a nanoglass, and a nano-polymer material.
In some embodiments of the invention, the antibody is selected from at least one of a C-reactive protein antibody, a thyrotropin antibody, a bilirubin antibody, an albumin antibody, a carcinoembryonic antigen antibody, a alpha fetoprotein antibody, a prostate specific antigen antibody, a cancer antigen 125 antibody, a cortisol antibody.
In some embodiments of the invention, the nucleic acid aptamer is selected from at least one of a DNA-type oligonucleotide strand, an RNA-type oligonucleotide strand.
In some embodiments of the invention, the polymer is selected from at least one of polyaniline, polypyrrole, polyacetylene, polycarbazole, polythiophene, polyphenylene methylene, poly (3, 4-ethylenedioxythiophene), polystyrene sulfonic acid, chitin, chitosan, polyvinylchloride, polyvinylbutyral, nafion.
In some embodiments of the invention, the ionophore is selected from at least one of potassium ion, sodium ion, calcium ion, magnesium ion, iron ion, zinc ion, manganese ion, copper ion, molybdenum ion, cobalt ion, chromium ion, chloride ion, sulfate ion, phosphate ion.
In some embodiments of the invention, the piezoelectric material is selected from at least one of single crystal piezoelectric ceramics, polycrystalline piezoelectric ceramics, piezoelectric polymers, polymer-piezoelectric ceramic composites.
In some embodiments of the present invention, the region of the main body frame corresponding to the location where the electrical signal transmission component is disposed forms an electrical signal transmission component assembly portion, and an outer dimension of the electrical signal transmission component assembly portion is equal to or greater than an outer dimension of the region of the electromagnetic shield in a direction toward the center of the main body frame.
In some embodiments of the present invention, the electrical signal transmission assembly mounting portion is provided with an electrical signal transmission assembly mounting groove, in which the electrical signal transmission assembly is mounted.
In some embodiments of the present invention, the main frame is made of a degradable polymer material; or the main body frame is made of at least one of shape memory alloy and iron, and the surface of the main body frame is provided with a dielectric layer, and the dielectric layer is arranged towards one side of the electric signal transmission component.
In some embodiments of the present invention, the material of the dielectric layer is selected from at least one of polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole, SU 8.
In some embodiments of the invention, the shape memory alloy is selected from at least one of nitinol, cobalt chrome, magnesium alloy.
In some embodiments of the invention, the vascular interventional medical device further comprises an insulating encapsulation layer arranged on the outermost layer of the main body frame on the side where the electrical signal transmission component is arranged, and exposing at least part of the electrodes.
In some embodiments of the present invention, the material of the insulating encapsulation layer is at least one selected from polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole, and SU 8.
In some embodiments of the invention, the vascular interventional medical device further comprises a buffer guard member provided at an implantation front end of the vascular interventional medical device, configured for reducing the risk of a puncture of a blood vessel during implantation of the vascular interventional medical device.
In some embodiments of the invention, the vascular interventional medical device further comprises a delivery component configured for implantation of the vascular interventional medical device deployment within a blood vessel.
In a second aspect of the invention, a vascular interventional medical system is proposed, comprising any of the vascular interventional medical devices proposed in the first aspect of the invention.
In a third aspect of the invention, the use of any of the above vascular interventional medical devices for constructing an in vitro culture cell construct, an electrical signal acquisition cell construct or an electrical stimulation cell construct is presented.
Drawings
The invention is further described with reference to the accompanying drawings and examples, in which:
FIG. 1 is a schematic diagram of a vascular interventional medical device according to an embodiment of the present invention;
FIG. 2 is a schematic view of the vascular interventional medical device of FIG. 1 after deployment along line A-A on the sidewall;
FIG. 3 is an enlarged view of a portion of region M of FIG. 2;
FIG. 4 is an enlarged cross-sectional view taken along line B-B of FIG. 3;
FIG. 5 is an enlarged view of a portion of the N region of FIG. 4;
FIG. 6 is a schematic view of the body frame of the vascular interventional medical device of FIG. 2 after deployment;
FIG. 7 is a schematic illustration of the structure of the dielectric layer of the vascular interventional medical device of FIG. 2 after deployment;
FIG. 8 is a schematic view of the first electromagnetic shield in the vascular interventional medical device of FIG. 2 after deployment;
FIG. 9 is a schematic view of the structure of a first insulating layer in the vascular interventional medical device shown in FIG. 2 after deployment;
FIG. 10 is a schematic view of the electrical signal transmission assembly of the vascular interventional medical device of FIG. 2 after deployment;
FIG. 11 is a schematic view of a second insulating layer of the vascular interventional medical device of FIG. 2 after deployment;
FIG. 12 is a schematic view of a second electromagnetic shield in the vascular interventional medical device of FIG. 2 after deployment;
fig. 13 is a schematic view of the structure of the insulating encapsulation layer in the vascular access medical device shown in fig. 2 after deployment.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
In the description of the present invention, the meaning of a number is one or more, the meaning of a number is two or more, and greater than, less than, exceeding, etc. are understood to exclude the present number, and the meaning of a number is understood to include the present number. The description of the first and second is for the purpose of distinguishing between technical features only and should not be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.
In the description of the present invention, unless explicitly defined otherwise, terms such as arrangement, installation, connection, etc. should be construed broadly and the specific meaning of the terms in the present invention can be reasonably determined by a person skilled in the art in combination with the specific contents of the technical scheme.
In the description of the present invention, the descriptions of the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Referring to fig. 1 to 5 and 10, the vascular interventional medical device includes a main body frame 10, an electrical signal transmission assembly 20, an insulating encapsulation layer 30, and an electromagnetic shield 40. Wherein the main body frame 10 is an elastic support frame; the electric signal transmission assembly 20 is arranged on the main body frame 10 and comprises an electrode 21 and a wire 22, and the wire 22 is electrically connected with the electrode 21; the insulating encapsulation layer 30 is disposed on the outermost layer of the main body frame 10 on the side where the electric signal transmission component 20 is disposed, and exposes at least part of the electrodes 21; the electromagnetic shield 40 is disposed between the insulating encapsulation layer 30 and the main body frame 10, and is configured to reduce or block interference of external electromagnetic signals on the electrical signals transmitted by the electrical signal transmission assembly.
The vascular interventional medical device is primarily configured for vascular interventional procedures, and the body frame 10 is generally configured to be collapsible and expandable along a central axis, to expand within a vessel following vasoconstriction, to facilitate implantation of the vessel, and to maintain the device in apposition with the vessel's inner wall for stable support. Specifically, the main body frame 10 may be designed to be hollow, such as hollow circular tube, hollow C-shaped tube, etc., and through the above tubular structure and elastically deformable design, the suitability with blood vessels can be improved, and the compatibility and detection accuracy can be improved. The main body frame 10 may be designed to have a diameter of 1 to 10mm, a length of 10 to 100mm, and a sidewall thickness of 10um to 1mm. In order to further reduce blood flow obstruction, improve the portability of the device structure and reduce the abnormal physical properties and discomfort caused by the intervention of the device into the living body, the main body frame 10 may be designed to have a side wall with a mesh structure; of course, in some embodiments, the side wall may have other hollowed-out designs, or even no hollowed-out designs. The main frame 10 of the mesh structure or other hollow structure may be formed by first setting a base support layer, and then hollowing out the base support layer by laser engraving or etching; alternatively, the main body frame 10 of the mesh structure may be woven by using a plurality of main body bars. Referring to fig. 1 to 6, in the present embodiment, the main body frame 10 is a hollow C-shaped tube with a mesh-shaped side wall.
In addition, the material of the main body frame 10 may be selected according to the need, and specifically, a deformable material having biocompatibility may be selected. For example, a degradable polymer material or at least one of a shape memory alloy and iron can be adopted, wherein the shape memory alloy specifically can be at least one of a nitinol alloy, a cobalt chromium alloy and a magnesium alloy. In addition, if the main body frame 10 is made of an electrically conductive material (such as a shape memory alloy, iron, etc.), electrical insulation between the main body frame 10 and other electrically conductive components is generally ensured, and thus a dielectric layer 50 for electrical insulation is generally disposed between the main body frame 10 and other electrically conductive components; if the main frame 10 is made of an insulating material, such as an insulating degradable polymer material, the dielectric layer 50 may be omitted. The material of the dielectric layer 50 may be at least one of Polyimide (PI), polydimethylsiloxane (PDMS), poly-p-Phenylene Benzobisoxazole (PBO), and SU 8. In this embodiment, the material of the main body frame 10 is selected from nitinol, and the surface of the main body frame 10 is provided with a dielectric layer 50 formed of polyimide, and the dielectric layer 50 is specifically disposed on the surface of the main body frame 10 on the side where the electrical signal transmission component 20 is disposed, as shown in fig. 4, 5 and 7.
The electrical signal transmission assembly 20 may be configured as desired. In some embodiments, the wires 22 and electrodes 21 may be provided on the body frame 10 and connected by resistance welding to form the electrical signal transmission assembly 20, wherein the wires 22 and electrodes 21 may be adhered or otherwise provided on the body frame 10. However, since the vascular interventional diagnosis and treatment device is small in size, if the wire 22 is disposed on the mesh structure of the main frame 10, the wire 22 is generally required to be small in size, and is connected to the electrode 21 by means of resistance welding, the connection stability is relatively poor, and further in this embodiment, the electrical signal transmission assembly 20 is configured by using a conductive material layer, and the conductive material layer is configured to form the electrical signal transmission assembly 20 including the electrode 21 and the wire 22, wherein the electrode 21 and the wire 22 are in an integrated structure, as shown in fig. 10. In the preparation process, the corresponding conductive material configuration can be adopted to form a conductive material base layer, and then the electrode 21 and the wire 22 are manufactured through processes such as laser engraving or etching, so as to form the electric signal transmission assembly 20. The above configuration of the conductive material layer forms the electric signal transmission component 20 containing the electrode 21 and the wire 22, which can meet the requirement of thin wires, the width of the wire 22 can be controlled below 100 μm, even below 25 μm, even less than 10 μm, such as 5 μm, 8 μm, etc., and the thickness can be controlled below 5 μm; and the electrode 21 and the lead 22 can be in an integrated structure, and can be subjected to blood flow scouring for a long time in a blood vessel, so that the blood vessel is not easy to break, and the blood vessel has strong stability and simple structure.
The electric signal transmission assembly 20 may be disposed on the inner side or the outer side of the main body frame 10, and may be specifically disposed according to the detection requirement. For example, if the target detection object of the vascular interventional diagnosis device is blood, the electrical signal transmission unit 20 may be provided inside the main body frame 10; if the target detection or action object of the vascular intervention diagnosis and treatment device is a blood vessel or a blood vessel wall cell, for example, the vascular intervention diagnosis and treatment device is used for electrically stimulating the blood vessel wall cell, the electrical signal transmission component 20 may be disposed outside the main body frame 10. As shown in fig. 1, in the present embodiment, the electric signal group transmission assembly 20 is disposed outside the main body frame 10. The electrical signal transmission assembly 20 or the conductive material layer from which the electrical signal transmission assembly 20 is constructed generally employs a biocompatible conductive material, including metallic and/or non-metallic conductive materials. For example, the conductive material layer that the electrical signal transmission assembly 20 is constructed of may be a metallic material layer, a non-metallic conductive material layer, or a composite layer of a non-metallic conductive material layer and a metallic material layer. Also, in order to ensure biocompatibility, a noble metal material such as platinum, gold, etc. is generally used for the metal material layer; the nonmetallic conductive material layer is usually made of nonmetallic conductive materials with biocompatibility, and the specific type is not limited; if the conductive material layer of the electrical signal transmission assembly 20 is formed by compounding a non-metal conductive material layer and a metal material layer, and the metal material layer is covered on the outer layer of the non-metal conductive material layer, the non-metal conductive material layer is isolated, and even the non-metal conductive material layer is not required to have biocompatibility, but only the metal material layer on the outermost layer is required to have biocompatibility, such as platinum, gold, etc. Wherein, in order to save cost or enhance conductivity, the conductive material layer constructing the electric signal transmission assembly 20 may be designed to be composed of a composite of a non-noble metal conductive base layer and a noble metal protective layer covering the non-noble metal conductive base layer. Wherein, the non-noble metal conductive base layer can be made of non-metal conductive material and/or non-noble metal-based material, for example, can be a non-metal conductive base layer or a non-noble metal-based metal conductive base layer; the noble metal protection layer may be made of at least one of platinum and gold. The metal material layer can be prepared by at least one of sputtering, vapor deposition and chemical vapor deposition, and the metal material layer prepared by the method has good uniformity and strong adhesion stability and can improve the stability of the structure.
The number of the electrodes 21 arranged on the electric signal transmission component 20 or the conductive material layer for constructing the electric signal transmission component 20 can be designed into one or more (such as 2, 3, 5, 8, 10, 15, 20, etc.), and the number can be specifically set according to actual needs, generally more than two, so as to realize multi-point detection or action and improve detection accuracy or action uniformity; and, the electrodes 21 can be uniformly distributed along the radial direction and/or the axial direction of the hollow tubular main body frame so as to further improve the detection accuracy or the action uniformity and the structural stability.
For the main body frame 10 with the side wall having the mesh structure, the electrodes 21 in the electric signal transmission assembly 20 can be arranged at the intersections of the mesh structure on the main body frame 10, so that the stability of the electrodes 21 can be improved. As shown in fig. 1 and 2, in the present embodiment, electrodes 21 are provided at the intersections of the mesh-like structures on the main body frame 10. In some embodiments, the electrodes 21 may be disposed at all intersections of the mesh structure on the main body frame 10; of course, in some embodiments, the electrode 21 may be located between the two intersections instead of at the intersections of the mesh structure on the main body frame 10. The shape of the electrode 21 can be designed according to the requirement, and a shape with a soft radian, such as a circle, an ellipse, a semicircle, a ring shape, etc., is generally adopted to improve the safety of the structure in the human body; of course, in some embodiments, the electrode 21 may take other shapes, such as square, etc.
In addition, the surface of the electrode 21 may be provided with a modification layer, which may be specifically configured to have a biological signal recognition function for recognizing and detecting a change in a biological signal in a blood vessel, and converting the change in the biological signal into a readable electrical signal through the electrode 21 for transmission to an external circuit; biological signals include chemical and/or physical signals related to the physiological condition of an organism (e.g., a human body). The chemical signal may be a chemical signal generated by a chemical reaction with a material of the modification layer, for example, when a specific biomarker in a blood vessel contacts with the modification layer with a biological signal recognition function modified on the surface of the electrode 21 during the use of the medical device, a chemical reaction occurs between the specific biomarker and the modification layer, and a change of the chemical signal generated by the chemical reaction is converted into a readable electric signal through the electrode 21 and is transmitted to an external circuit. The physical signal may be at least one of temperature, blood flow velocity, blood pressure, for example, when the above physical signal in the blood vessel changes during use of the medical device, the change will cause a responsive change in the physical properties of the surface modification layer of the electrode 21, which in turn will be converted into a readable electrical signal by the electrode 21 for transmission to an external circuit.
The specific material selection of the modification layer is not limited, and the biological signal identification function can be realized. For example, it may be one or more of enzymes, redox mediators, nanomaterials, antibodies, biotin, nucleic acid aptamers, polymers, ionophores, piezoelectric materials.
Wherein the enzyme includes, but is not limited to, at least one of an oxidoreductase, a transferase, a hydrolase, a lyase, a ligase, an isomerase.
Oxidoreductases include, but are not limited to, glucose oxidase, glutamate oxidase, alcohol oxidase, lactate oxidase, amino acid oxidase, cholesterol oxidase, choline oxidase, nicotinamide adenine dinucleotide phosphate oxidase, oxalate oxidase, cytochrome oxidase, bilirubin oxidase, serotonin, galactose oxidase, glucose dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, glutamate dehydrogenase, pyruvate dehydrogenase, sorbitol dehydrogenase, formate dehydrogenase, cellobiose dehydrogenase, amino acid dehydrogenase, succinate dehydrogenase, catalase, horseradish peroxidase, lactoperoxidase, glutathione peroxidase, ascorbate peroxidase, soybean peroxidase, cytochrome peroxidase, thyroid peroxidase, myeloperoxidase, superoxide dismutase, haloperoxidase, thiol peroxidase, 5α reductase, 5β reductase, aldehyde reductase, aldose reductase, hydroxymethylglutarate monoacyl-CoA reductase, methemoglobin reductase, ribonucleotide reductase, nitroreductase, thioredoxin reductase, dihydrofolate reductase, disulfide reductase, sulfite reductase, cytochrome reductase, imine reductase, fumarate reductase, carboxylate reductase, dimethyl sulfoxide reductase.
Transferases include, but are not limited to, at least one of glutathione transferases, acetyl transferases, methyltransferases, transketolase, transaldolase, glycosyltransferases, transketolase, amino acid transferases, and acyltransferases.
The hydrolytic enzymes include, but are not limited to, at least one of a lipohydrolase, a phosphohydrolase, a glycoside hydrolase, an acetyl hydrolase, a nucleotide hydrolase, a helicase, a peptide hydrolase, a urease, a creatinine deiminase.
The lyase includes, but is not limited to, at least one of a decarboxylase, a dehydrogenase, a dehalogenase, an aspartate ammonia lyase, a cysteine desulphurase.
The ligase includes, but is not limited to, at least one of tRNA synthetase, succinyl-side enzyme A synthetase, amino acid ligase, DNA ligase, RNA ligase, carboxylase.
The isomerase includes, but is not limited to, at least one of racemase, epimerase, mutase.
The nanomaterial includes, but is not limited to, one or more of metal nanomaterial, nanoceramics, nanoglass, and nano-polymer materials.
Antibodies include, but are not limited to, one or more of C-reactive protein antibodies, thyrotropin antibodies, bilirubin antibodies, albumin antibodies, carcinoembryonic antigen antibodies, alpha fetoprotein antibodies, prostate specific antigen antibodies, cancer antigen 125 antibodies, cortisol antibodies.
The nucleic acid aptamer is selected from at least one of a DNA type oligonucleotide chain and an RNA type oligonucleotide chain.
The polymer is selected from one or more of polyaniline, polypyrrole, polyacetylene, polycarbazole, polythiophene, polyphenylene methylene, poly (3, 4-ethylenedioxythiophene), polystyrene sulfonic acid, chitin, chitosan, polyvinyl chloride, polyvinyl butyral and Nafion.
The ionophore is selected from one or more of potassium ion, sodium ion, calcium ion, magnesium ion, iron ion, zinc ion, manganese ion, copper ion, molybdenum ion, cobalt ion, chromium ion, chloride ion, sulfate ion and phosphate ion.
The piezoelectric material is at least one selected from single crystal piezoelectric ceramics, polycrystalline piezoelectric ceramics, piezoelectric polymers and polymer-piezoelectric ceramic composites.
Specifically, in the above modification layer material, the mechanism of action of a part of the modification layer material is as follows: when the vascular interventional diagnosis and treatment device is implanted into a blood vessel for use, if the modification layer detects the corresponding biological signal edge change, the modification layer material can generate corresponding chemical reaction, electrons or consumed electrons can be generated in the chemical reaction process, the change of the number of the electrons is excited by a signal of an external circuit to conduct through an electrode below the modification layer and generate an electric signal, and the electric signal is finally transmitted to the external circuit to form a readable signal. Wherein the enzyme and the redox mediator are mainly coordinated to realize the mechanism, and the nanomaterial alone or together with the redox mediator can also realize the mechanism. For example, if glucose oxidase is used as the material of the modification layer, glucose molecules are present in the blood vessel, glucose oxidase will react specifically with glucose, electrons generated by this reaction will transfer to oxygen in the blood and generate hydrogen peroxide at the electrode surface, hydrogen peroxide will react chemically under the excitation of a suitable external circuit voltage, and electrons will flow from the electrode into the circuit under the drive of the electric field force, and a readable current signal will be generated in the external circuit, the magnitude of which is related to the glucose concentration in the blood vessel, and thus can be used to determine the intravascular glucose concentration.
The mechanism of action of the partial finishing layer material is as follows: when the vascular interventional diagnosis and treatment device is implanted into a blood vessel for use, if the modification layer detects the change of biological signals in the blood vessel, the material of the modification layer can be subjected to corresponding chemical change, the impedance property of the modification layer can be changed after chemical reaction, the change of the impedance property can be detected through an electrode below the modification layer under the signal excitation of an external circuit and an electrical impedance signal is generated, and finally the electrical impedance signal can be transmitted to the external circuit to form a readable signal. Wherein, the nano material, the antibody, the biotin, the aptamer and the polymer can be singly or mutually matched to realize the mechanism. For example, if a cortisol antibody is used as the material of the modification layer, when a cortisol molecule is present in the blood vessel, the cortisol molecule will specifically and chemically bind to the cortisol antibody, and the binding will result in an increase in impedance of the electrode surface, and the change in impedance signal can be read in an external circuit, and the magnitude of the change in electrical impedance signal is correlated with the concentration of the cortisol molecule in the blood vessel, so that the electrical impedance signal can be used to determine the concentration of cortisol in the blood vessel.
The electromagnetic shielding member 40 is configured to reduce or block interference of external electromagnetic signals on the electrical signal transmitted by the electrical signal transmission assembly, and specifically, the electromagnetic shielding member 40 may be disposed on at least one side of the electrical signal transmission assembly 20, where the manner of disposition may be configured according to actual needs (including detection needs of the vascular intervention medical device and the disposition location of the electrical signal transmission assembly 20). For example, if the electrical signal transmission assembly 20 is disposed on the inner side of the main body frame 10, the electromagnetic shielding member 40 may be disposed between the electrical signal transmission assembly 20 and the main body frame 10, and the electromagnetic shielding member 40 is disposed on the outer side of the electrical signal transmission assembly 20, so that the interference of external electromagnetic signals may be reduced to some extent; if the electric signal transmission assembly 20 is disposed on the outer side of the main body frame 10, the electromagnetic shielding member 40 can be disposed on the electric signal transmission assembly 20 at a side away from the main body frame 10, and the electromagnetic shielding member 40 covers the wires 22 and exposes at least part of the electrodes 21, so that the electromagnetic shielding member 40 is also disposed on the outer side of the electric signal transmission assembly 20, and interference of external electromagnetic signals can be reduced to a certain extent; in some embodiments, the electromagnetic shielding member 40 disposed between the electrical signal transmission assembly 20 and the main body frame 10 and on the side of the electrical signal transmission assembly 20 facing away from the main body frame 10, which covers the conductive wires 22 and exposes at least part of the electrodes 21, can also be used to cooperate to improve the electromagnetic shielding effect by disposing the electromagnetic shielding member 40 on both sides of the electrical signal transmission assembly 20.
In this embodiment, the electromagnetic shielding assembly 40 is configured to be disposed around the electrical signal transmission assembly 20 and expose at least a portion of the electrodes 21. Specifically, as shown in fig. 4 to 5 and fig. 8 and 12, in the present embodiment, the battery shielding assembly 40 includes a first electromagnetic shielding member 41 and a second electromagnetic shielding member 42, the first electromagnetic shielding member 41 is disposed between the electric signal transmission assembly 20 and the main body frame 10, the second electromagnetic shielding member 42 is disposed on a side of the electric signal transmission assembly 20 facing away from the main body frame 10, covers the lead wire 22 and exposes at least part of the electrode 21; the second electromagnetic shielding piece 42 is provided with a conductive connecting part 43, the second electromagnetic shielding layer 42 is connected with the first electromagnetic shielding piece 41 through the conductive connecting part 43, the conductive connecting part 43 (only part is shown in fig. 12) is uniformly distributed on the second electromagnetic shielding piece 42 in the circumferential direction corresponding to the electric signal transmission assembly 20, and then the first electromagnetic shielding piece 41, the second electromagnetic shielding piece 42 and the conductive connecting part 43 between the first electromagnetic shielding piece and the second electromagnetic shielding piece are arranged around the electric signal transmission assembly 20, and through the surrounding arrangement of the electric signal transmission assembly 20, the omnibearing protection can be realized, and the interference of external electromagnetic signals to electric signals transmitted by the electric signal transmission assembly 20 is effectively blocked.
In some embodiments, the electromagnetic shielding member 40 is generally an electrically conductive electromagnetic shielding member, and based on its electrical conductivity, when it is configured in combination with the electrical signal transmission assembly 20, it is required to control the electrical insulation between the electromagnetic shielding member 40 and the electrical signal transmission assembly 20, and further an insulating layer 60 may be disposed between the electromagnetic shielding member 40 and the electrical signal transmission assembly 20 to electrically insulate the electromagnetic shielding member 40 from the electrical signal transmission assembly 20. Of course, in some embodiments, other insulating connection supports (e.g., insulating rod support rods, etc.) may be provided to provide insulating separation connection of electromagnetic shield 40 and electrical signal transmission assembly 20. The electromagnetic shielding member 40 may be specifically any one of a metal shielding layer, a carbon nanotube shielding layer, a ferrite shielding layer, and a graphene shielding layer, and the metal shielding layer may be made of at least one of platinum and gold, and may be made by at least one of sputtering, vapor deposition, and chemical vapor deposition. The insulating layer 60 may be made of at least one of polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole, and SU 8.
In this embodiment, the first electromagnetic shield 41 and the second electromagnetic shield 42 are metal platinum shielding layers, and the conductive connection portion 43 and the second electromagnetic shield 42 are made of the same material; an insulating layer 60 made of polyimide is arranged between the electromagnetic shielding member 40 and the electric signal transmission assembly 20, specifically, as shown in fig. 4 to 5, 9 and 11, the insulating layer 60 comprises a first insulating layer 61 and a second insulating layer 62, the first insulating layer 61 is arranged between the first electromagnetic shielding member 41 and the electric signal transmission assembly 20, the second insulating layer 62 is arranged between the second electromagnetic shielding member 42 and the electric signal transmission assembly 20, through holes 63 are formed in the first insulating layer 61 and the second insulating layer 62 corresponding to the conductive connecting portions 43 on the second electromagnetic shielding member 42, and the conductive connecting portions 43 on the second electromagnetic shielding member 42 are connected with the first electromagnetic shielding member 41 through the through holes 63.
In addition, in some embodiments, the electromagnetic shielding member 40 may also be configured to include an insulating layer and a conductive layer, where the insulating layer is disposed in a manner of being attached to the electrical signal transmission component 20, and the conductive layer is disposed on a surface of the insulating layer facing away from the electrical signal transmission component 20, and the conductive layer is mainly used to implement electromagnetic shielding, and the insulating layer is used to implement electrical insulation between the conductive layer and the electrical signal transmission component 20, and may play a role in connection and support between the conductive layer and the electrical signal transmission component 20. The conducting layer is selected from any one of a metal layer, a carbon nano tube layer, a ferrite layer and a graphene layer, and the insulating layer is made of at least one of polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole and SU 8.
In order to ensure the effective anti-interference effect of the electromagnetic shielding member 40 on the signal transmitted by the electrical signal transmission assembly 20, the outer dimension of the electromagnetic shielding member 40 is generally designed to be greater than or equal to the dimension of the corresponding electrical signal transmission assembly 20 along the direction toward the center of the main body frame 10, and the corresponding location area of the electrical signal transmission assembly 20 on the main body frame 10 can be regarded as forming the electrical signal transmission assembly, the electromagnetic shielding member 40 protects the electrical signal transmission assembly 20, and further in order to improve the stability of the structural arrangement, the outer dimension of the electrical signal transmission assembly along the direction toward the center of the main body frame 10 can be designed to be equal to or greater than the outer dimension of the corresponding area on the electromagnetic shielding member 40. Specifically, the electric signal transmission assembly assembling portion includes an electrode assembling portion constituted by the corresponding set position region of the electrode 21 in the electric signal transmission assembly 20 on the main body frame 10, and a wire assembling portion constituted by the corresponding set position region of the wire 22 in the electric signal transmission assembly 20 on the main body frame 10, and further may be designed such that the outer peripheral dimension on the electrode assembling portion is equal to or greater than the outer peripheral dimension of the corresponding region on the electromagnetic shield 40 in the direction toward the center of the main body frame 10, and the outer peripheral dimension of the wire assembling portion is equal to or greater than the outer peripheral dimension of the corresponding region on the electromagnetic shield 40. Further, the outer contour shape of the electric signal transmission assembly fitting portion on the main body frame 10 may be designed to be the same as the outer contour shape of the corresponding region on the electromagnetic shield 40, and the outer contour size of the electric signal transmission assembly fitting portion is equal to or slightly larger than the outer contour size of the corresponding region on the electromagnetic shield 40; alternatively, the outer contour shape of the electric signal transmission assembly assembling portion on the main body frame 10 may be designed to be different from the outer contour shape of the corresponding region on the electromagnetic shield 40, and the outer contour size of the electric signal transmission assembly assembling portion on the main body frame 10 is larger than the outer contour size of the corresponding region on the electromagnetic shield 40, that is, the outer contour of the region of the electric signal transmission assembly 20 on the main body frame 10 corresponding to the setting position is larger than the outer contour of the corresponding region on the electromagnetic shield 40 in the radial direction of the main body frame 10. With the above structural design, the main body frame 10 can fully support the electric signal transmission assembly 20 and the electromagnetic shield 40, thereby further improving structural stability.
In some embodiments, an electric signal transmission member fitting groove may be further provided on the electric signal transmission member fitting portion of the main body frame 10, in which the electric signal transmission member 20 is fitted. In some embodiments in which the electromagnetic shield 40 is disposed between the electrical signal transmission assembly 20 and the main body frame 10, the electrical signal transmission assembly 20 is mounted in the electrical signal transmission assembly mounting groove, and the electromagnetic shield 40 is further disposed between the electrical signal transmission assembly 20 and the main body frame 10. Through this structure setting, electric signal transmission subassembly 20 installs in electric signal transmission subassembly assembly groove, on the one hand can reduce the thickness size of structure, on the other hand, and the lateral wall in electric signal transmission subassembly assembly groove can carry out spacingly to electric signal transmission subassembly 20, avoids electric signal transmission subassembly 20 to shift in the use, further improves structural stability.
As shown in fig. 1, 4, 5 and 13, the vascular interventional medical device of the present embodiment further includes an insulating encapsulation layer 30, where the insulating encapsulation layer 30 is disposed on the outermost layer of the main body frame 10 on the side where the electrical signal transmission component 20 is disposed, and exposes at least part of the electrodes 21, so as to perform insulation, encapsulation and protection functions. Specifically, a through hole may be formed on the insulating encapsulation layer 30 at a position corresponding to the electrode 21, so as to expose at least a portion of the electrode 21. The material of the insulating encapsulation layer 30 may be at least one of Polyimide (PI), polydimethylsiloxane (PDMS), poly-p-Phenylene Benzobisoxazole (PBO), and SU 8.
In some embodiments, the provision of the insulating encapsulation layer 30 may also be eliminated. For example, when the electromagnetic shielding member 40 is disposed on the side of the electrical signal transmission assembly 20 facing away from the main body frame 10, the electromagnetic shielding member 40 disposed on the side of the electrical signal transmission assembly 20 facing away from the main body frame 10 can perform a certain packaging and protecting function on the electrical signal transmission assembly 20, so that the insulating packaging layer 30 can be omitted. The case where the electromagnetic shield 40 is provided on the side of the electric signal transmission assembly 20 facing away from the main body frame 10 includes: the electromagnetic shielding member 40 is arranged on one side of the electric signal transmission assembly 20, which is away from the main body frame 10, covers the lead wires 22 and exposes at least part of the electrodes 21; alternatively, the electromagnetic shield 40 is disposed between the electrical signal transmission assembly 20 and the main body frame 10, and on a side of the electrical signal transmission assembly 20 facing away from the main body frame 10, covers the wires 22 and exposes at least part of the electrodes 21; still alternatively, the electromagnetic shield 40 is disposed about the electrical signal transmission assembly 20 and exposes at least a portion of the electrode 21.
Additionally, in some embodiments, to increase the safety of the vascular access medical device implantation procedure, the vascular access medical device may further comprise a buffer protection component configured to reduce the risk of puncturing the blood vessel during the vascular access medical device implantation procedure, and in particular the buffer protection component may be provided at the implantation front end of the vascular access medical device. In addition, the buffer protection component can be designed to be deployed and intervened that the front end is provided with an arc buffer surface, for example, the buffer protection component can be designed to be spherical, semi-spherical, ellipsoidal, semi-ellipsoidal and the like, and the arc buffer surface of the front end is deployed and intervened through the buffer protection component, so that the buffer protection component can play an effective buffer protection role in the process of deploying and implanting blood vessels, and the risk of stabbing the blood vessels is reduced.
In some embodiments, the above vascular interventional medical device may be used with an external delivery member to deploy the vascular interventional medical device to a target site implanted in a blood vessel when deployed in use. Of course, in some embodiments, the vascular interventional procedure device may also be designed to include a delivery component itself, which is configured for deployment of the vascular interventional procedure device into a blood vessel. The transport member may employ a transport shaft, which may be configured to pass through the main body frame 10, and one end is connected to a deployment front end of the main body frame 10 or a buffer protection member provided at the deployment front end of the main body frame 10.
The above vascular intervention medical device can be applied to a vascular intervention medical system, and the invention further provides a vascular intervention medical system comprising any of the above vascular intervention medical devices. Specifically, one end of the lead 22 of the electrical signal transmission assembly 20 in the vascular interventional medical device is connected to the electrode 21 on the electrical signal transmission assembly 20, and the lead 22 extends along the side wall of the main body frame 10 and is configured to be led out for electrical connection with external equipment. The external device may be provided as desired, for example, in some embodiments, the external device is only used to receive signal data detected by the electrodes and transmitted over the wires; alternatively, in some embodiments, the external device may process the signal data detected by the electrodes and transmitted through the wires to obtain target signal data in addition to receiving the signal data; or, in some embodiments, the external device may further generate a control signal in addition to receiving and processing the signal data transmitted by the vascular interventional diagnosis and treatment device, and transmit the control signal to other devices; alternatively still, the external device may be a driving power source to apply electrical stimulation to the vessel wall cells through the leads and electrodes; in addition, other external devices may be configured as desired.
In addition, the vascular intervention medical system can be applied to a framework in-vitro culture cell construct, an electrical signal acquisition cell construct and an electrical stimulation cell construct, and further the application also provides application of the vascular intervention medical system in constructing the in-vitro culture cell construct, the electrical signal acquisition cell construct or the electrical stimulation cell construct.
The foregoing examples illustrate only a few embodiments of the application and are described in detail herein without thereby limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application.
Claims (10)
1. A vascular interventional medical device, comprising:
the main body frame is an elastic supporting frame;
the electric signal transmission assembly is arranged on the main body frame and comprises an electrode and a wire, and the wire is electrically connected with the electrode;
an electromagnetic shield configured to reduce or block interference of external electromagnetic signals with electrical signals transmitted by the electrical signal transmission assembly.
2. The vascular interventional medical device of claim 1, wherein the electromagnetic shield is provided on at least one side of the electrical signal transmission assembly;
preferably, the electromagnetic shield is arranged in any one of the following ways:
setting mode one: the electromagnetic shielding piece is arranged on one side, away from the main body frame, of the electric signal transmission assembly, covers the lead and exposes at least part of the electrode;
setting mode II: the electromagnetic shielding piece is arranged between the electric signal transmission assembly and the main body frame;
setting mode III: the electromagnetic shielding piece is arranged between the electric signal transmission assembly and the main body frame and is arranged on one side, away from the main body frame, of the electric signal transmission assembly, covers the lead and exposes at least part of the electrode; and the setting mode is four: the electromagnetic shield is disposed around the electrical signal transmission assembly and exposes at least a portion of the electrodes.
3. The vascular interventional medical device according to claim 2, wherein an insulating layer is provided between the electromagnetic shield and the electrical signal transmission assembly;
preferably, the electromagnetic shield is selected from any one of a metal shielding layer, a carbon nanotube shielding layer, a ferrite shielding layer, and a graphene shielding layer; preferably, the material of the metal shielding layer is at least one selected from platinum and gold;
Preferably, the material of the insulating layer is at least one selected from polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole and SU 8.
4. The vascular interventional medical device of claim 1, wherein the electrical signal transmission assembly is configured from a layer of conductive material; preferably, the electrode and the lead are in an integrated structure;
preferably, the conductive material layer is a metal material layer, a non-metal conductive material layer or a composite layer of the non-metal conductive material layer and the metal material layer;
preferably, the conductive material layer comprises a non-noble metal conductive base layer and a noble metal protective layer, the non-noble metal conductive base layer is arranged on the surface of the main body frame, and the noble metal protective layer covers the non-noble metal conductive base layer; the noble metal protective layer is made of at least one of platinum and gold;
preferably, the thickness of the conductive material layer is 5 μm or less.
5. The vascular interventional medical device of claim 1, wherein the body frame is configured to be contracted and expanded along a central axis;
preferably, the main body frame is hollow tubular;
preferably, the side wall of the main body frame is in a net structure;
Preferably, the electrodes are arranged at the intersections of the mesh structures on the main body frame;
preferably, the number of the electrodes is two or more;
preferably, the electrodes are uniformly distributed along the radial direction and/or the axial direction of the main body frame;
preferably, the surface of the electrode is provided with a modification layer, the modification layer has a biological signal recognition function and is used for recognizing and detecting the change of the biological signal in the blood vessel, and the change of the biological signal is converted into a readable electric signal through the electrode and is transmitted to an external circuit; the biological signal comprises a chemical signal and/or a physical signal related to a physiological condition of an organism; preferably, the material of the modification layer is at least one selected from enzyme, redox mediator, nanomaterial, antibody, biotin, aptamer, polymer, ionophore, piezoelectric material;
preferably, the enzymatic enzyme is selected from at least one of oxidoreductase, transferase, hydrolase, lyase, ligase, isomerase;
preferably, the method comprises the steps of, the oxidoreductase is selected from the group consisting of glucose oxidase, glutamate oxidase, alcohol oxidase, lactate oxidase, amino acid oxidase, cholesterol oxidase, choline oxidase, nicotinamide adenine dinucleotide phosphate oxidase, oxalate oxidase, cytochrome oxidase, bilirubin oxidase, serotonin, galactose oxidase, glucose dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, glutamate dehydrogenase, pyruvate dehydrogenase, sorbitol dehydrogenase, formate dehydrogenase, cellobiose dehydrogenase, amino acid dehydrogenase, succinate dehydrogenase, catalase, horseradish peroxidase, lactoperoxidase, glutathione peroxidase, bilirubin oxidase, and glucose dehydrogenase at least one of ascorbate peroxidase, soybean peroxidase, cytochrome peroxidase, thyroid peroxidase, myeloperoxidase, superoxide dismutase, haloperoxidase, thiol peroxidase, 5α reductase, 5β reductase, aldehyde reductase, aldose reductase, hydroxymethylglutarate monoacyl-CoA reductase, methemoglobin reductase, ribonucleotide reductase, nitroreductase, thioredoxin reductase, dihydrofolate reductase, disulfide reductase, sulfite reductase, cytochrome reductase, imine reductase, fumarate reductase, carboxylate reductase, dimethyl sulfoxide reductase;
Preferably, the transferase is at least one selected from glutathione transferase, acetyl transferase, methyltransferase, transketolase, transaldolase, glycosyltransferase, transketolase, amino acid transferase, and acylase;
preferably, the hydrolase is at least one selected from the group consisting of a lipohydrolase, a phosphohydrolase, a glycoside hydrolase, an acetyl hydrolase, a nucleotide hydrolase, a helicase, a peptide hydrolase, a urease, and a creatinine deiminase;
preferably, the lyase is selected from at least one of decarboxylase, dehydrogenase, dehalogenase, aspartate ammonia lyase, cysteine desulphurase;
preferably, the ligase is selected from at least one of tRNA synthetase, succinyl, and enzyme A synthetase, amino acid ligase, DNA ligase, RNA ligase, and carboxylase;
preferably, the isomerase is at least one selected from racemase, epimerase and mutase;
preferably, the nanomaterial is at least one selected from a metal nanomaterial, a nano ceramic, a nano glass and a nano polymer material;
preferably, the antibody is at least one selected from the group consisting of a C-reactive protein antibody, a thyrotropin antibody, a bilirubin antibody, an albumin antibody, a carcinoembryonic antigen antibody, a alpha fetoprotein antibody, a prostate specific antigen antibody, a cancer antigen 125 antibody, and a cortisol antibody;
Preferably, the nucleic acid aptamer is selected from at least one of a DNA-type oligonucleotide strand, an RNA-type oligonucleotide strand;
preferably, the polymer is at least one selected from polyaniline, polypyrrole, polyacetylene, polycarbazole, polythiophene, polyphenylene methylene, poly (3, 4-ethylenedioxythiophene), polystyrene sulfonic acid, chitin, chitosan, polyvinyl chloride, polyvinyl butyral, nafion;
preferably, the ionophore is at least one selected from potassium ion, sodium ion, calcium ion, magnesium ion, iron ion, zinc ion, manganese ion, copper ion, molybdenum ion, cobalt ion, chromium ion, chloride ion, sulfate ion, and phosphate ion;
preferably, the piezoelectric material is at least one selected from the group consisting of single crystal piezoelectric ceramics, polycrystalline piezoelectric ceramics, piezoelectric polymers, and polymer-piezoelectric ceramic composites.
6. The vascular interventional medical device according to claim 1, wherein the region of the main body frame corresponding to the position where the electrical signal transmission member is provided constitutes an electrical signal transmission member fitting portion, and an outer peripheral dimension of the electrical signal transmission member fitting portion is equal to or larger than an outer peripheral dimension of the region corresponding to the electromagnetic shield in a direction toward a center of the main body frame;
Preferably, the electric signal transmission assembly part is provided with an electric signal transmission assembly groove, and the electric signal transmission assembly is assembled in the electric signal transmission assembly groove.
7. The vascular interventional medical device according to any one of claims 1 to 6, wherein the main body frame is made of a degradable polymer material;
or the main body frame is made of at least one of shape memory alloy and iron, and the surface of the main body frame is provided with a dielectric layer, and the dielectric layer is arranged towards one side of the electric signal transmission component;
preferably, the material of the dielectric layer is at least one selected from polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole and SU 8;
preferably, the shape memory alloy is at least one selected from nitinol alloy, cobalt chromium alloy, magnesium alloy.
8. The vascular interventional medical device according to any one of claims 1 to 6, further comprising an insulating encapsulation layer arranged on the outermost layer of the main body frame on the side where the electrical signal transmission assembly is arranged, exposing at least part of the electrodes; preferably, the material of the insulating packaging layer is at least one selected from polyimide, polydimethylsiloxane, poly-p-phenylene benzobisoxazole and SU 8;
Preferably, the medical device further comprises a buffer protection component arranged at the implantation front end of the vascular intervention medical device and configured to reduce the risk of puncturing a blood vessel during the implantation process of the vascular intervention medical device;
preferably, a delivery component is also included, the delivery component configured for deploying the vascular interventional medical device into a blood vessel.
9. A vascular interventional medical system comprising a vascular interventional medical device according to any one of claims 1 to 8.
10. Use of the vascular interventional medical system of claim 9 for constructing an in vitro culture cell construct, an electrical signal acquisition cell construct or an electrical stimulation cell construct.
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| CN117204827A (en) * | 2023-08-15 | 2023-12-12 | 柔脉医疗(深圳)有限公司 | Vascular intervention diagnosis and treatment device, system and application thereof |
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