CN117150798B - Irreversible electroporation pulse ablation electrode construction method and system - Google Patents
Irreversible electroporation pulse ablation electrode construction method and system Download PDFInfo
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- 238000010276 construction Methods 0.000 title claims abstract description 55
- 238000002679 ablation Methods 0.000 title claims abstract description 45
- 230000002427 irreversible effect Effects 0.000 title claims abstract description 41
- 238000004520 electroporation Methods 0.000 title claims abstract description 40
- 239000007772 electrode material Substances 0.000 claims abstract description 176
- 230000002457 bidirectional effect Effects 0.000 claims abstract description 48
- 238000000034 method Methods 0.000 claims abstract description 35
- 210000005077 saccule Anatomy 0.000 claims abstract description 18
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- 238000002474 experimental method Methods 0.000 description 4
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Abstract
The invention relates to the technical field of pulse ablation, and discloses an electrode construction method and system for irreversible electroporation pulse ablation, wherein the method comprises the following steps: collecting electrode materials of the saccule, identifying uniform extensibility of the electrode materials, and constructing electrode lines of the electrode materials based on the uniform extensibility; acquiring length data of the saccule, and selecting the electrode quantity of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material; using electrode lines and electrode quantity, configuring annular electrodes on the surface of the saccule, and constructing electrode polarities of the annular electrodes; based on electrode polarity, constructing a bidirectional asymmetric pulse circuit of the annular electrode, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit; and driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon. The invention can promote the simplicity of the electrode construction process of irreversible electroporation pulse ablation.
Description
Technical Field
The invention relates to the technical field of pulse ablation, in particular to an electrode construction method and system for irreversible electroporation pulse ablation.
Background
Foam cell formation is an early event of atherosclerosis, in the early stage of atherosclerosis, monocytes in blood are differentiated into macrophages under an inner membrane through endothelial gaps, the macrophages mediate permeation of low density lipoprotein cholesterol under vascular endothelium to be oxidatively modified to form oxidized low density lipoprotein cholesterol, and a large amount of oxidized low density lipoprotein cholesterol is phagocytized by an A-type clear channel receptor to lead to intracellular lipid accumulation, so that foam cells are formed, and the foam cells are accumulated to form lipid stripes and even lipid plaques, therefore, the foam cells need to be subjected to ablation treatment, irreversible electroporation pulse ablation technology can act on the foam cells, nanoscale irreversible pores are formed on the surface of the foam cells, foam cell scorch is induced, smooth muscle and muscle fiber injury can not be caused by the energy, no scar is formed, and atherosclerosis can be effectively treated.
At present, an irreversible electroporation pulse ablation technology is characterized in that an indispensable saccule can carry an electrode on the surface, the scorching of foam cells is realized through electrode discharge, the discharge with different intensities can cause different degrees of influence on the foam cells, the prior art always needs to calculate parameters such as high-voltage pulse electric field intensity and the like in advance, simulation is carried out based on the calculated parameters, a large number of comparison experiments are needed in the process, the process is complicated, the saccule can expand after being filled with fluid substances, therefore, the electrode on the surface of the saccule can also be distorted, the problem is solved by two methods in the prior art, firstly, a small-deformation polyurethane material is selected to replace the electrode, secondly, the electrode and the saccule are peeled off when the saccule is deformed, so that the deformation of the electrode is synchronously changed along with the deformation of the saccule, but the deformation of the electrode is far smaller than the deformation of the saccule, and the defect that the two processes need to be additionally provided with materials to change the original short and brief processes into complicated processes is overcome. Thus, the electrode construction process of irreversible electroporation pulse ablation is not simple enough.
Disclosure of Invention
In order to solve the problems, the invention provides an electrode construction method and an electrode construction system for irreversible electroporation pulse ablation, which can improve the simplicity of the electrode construction process of irreversible electroporation pulse ablation.
In a first aspect, the present invention provides a method of electrode construction for irreversible electroporation pulse ablation, comprising:
Collecting electrode materials of the saccule, identifying uniform elongation rate of the electrode materials, and constructing electrode lines of the electrode materials based on the uniform elongation rate;
Acquiring length data of the balloon, and selecting the electrode quantity of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material;
Using the electrode lines and the electrode quantity, configuring annular electrodes on the surface of the saccule, and constructing electrode polarities of the annular electrodes;
based on the electrode polarity, constructing a bidirectional asymmetric pulse circuit of the annular electrode, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit;
And driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon.
In a possible implementation manner of the first aspect, the constructing an electrode texture of the electrode material based on the uniform elongation includes:
Selecting a target electrode material from the electrode materials based on the uniform elongation;
Constructing radial electrode lines of the target electrode material based on the uniform elongation;
Constructing circumferential electrode lines of the target electrode material based on the uniform elongation;
And determining the electrode texture of the electrode material by using the radial electrode texture and the annular electrode texture.
In a possible implementation manner of the first aspect, the selecting a target electrode material from the electrode materials based on the uniform elongation includes:
calculating the radial shortest length of the electrode material:
Calculating the circumferential shortest length of the electrode material:
calculating the length sum of the radial shortest length and the circumferential shortest length:
and taking the length, the middle maximum length and the corresponding electrode material as the target electrode material.
In a possible implementation manner of the first aspect, the constructing a radial electrode texture of the target electrode material based on the uniform elongation includes:
calculating an extension length of the electrode material based on the uniform elongation;
calculating an initial length of the electrode material based on the extension length;
Based on the initial length, a length parameter of the electrode material is calculated using the following formula:
f(x)＝Asin(αx+β)
Wherein (α, β) represents a length parameter of the electrode material, f (x) represents a curve function formed by the electrode material when the electrode material is provided with electrode lines, a represents a height, 2 times a represents a width of the electrode material when the electrode material is provided with electrode lines, the width cannot exceed a preset standard width, x represents a coordinate of the electrode material in a horizontal direction, a represents a starting point of the electrode material in the horizontal direction, the starting point is positioned at a dome position of a cone at a near end, and b represents an abscissa of the cone at a far end;
and determining radial electrode lines of the electrode material based on the length parameters.
In a possible implementation manner of the first aspect, the selecting, based on the dual-electrode discharge intensity of the electrode material, the number of electrodes of the electrode material using the length data includes:
Determining an electrode spacing between a positive electrode and a negative electrode in the electrode material based on the double-electrode discharge intensity;
Spacing the electrode from the cylinder based on the cylinder height in the length data;
spacing the electrode from the bottom surface circumference based on the length data;
and determining the electrode number of the electrode material by using the circumferential electrode number and the radial electrode number.
In a possible implementation manner of the first aspect, the determining, based on the dual-electrode discharge intensity, an electrode interval between a positive electrode and a negative electrode in the electrode material includes:
based on the discharge intensity of the double electrodes, a relation model between the electrode distance between the positive electrode and the negative electrode in the electrode material and the discharge current between the positive electrode and the negative electrode in the electrode material is constructed by using the following formula:
k＝m1v
vwm2e
Wherein, Representing the relation model, k representing the electrode spacing, m 1、m2、m3、m4 representing a positive number parameter, v representing a net space volume, k=m 1 v representing that as the electrode spacing increases, the net space volume increases, e representing the double electrode discharge intensity, u representing a jump-in voltage, i representing a discharge current between the positive electrode and the negative electrode in the electrode material;
constructing a relation curve between the electrode spacing and the discharge current based on the relation model;
And taking the electrode spacing corresponding to the maximum discharge current of the discharge currents in the relation curve as the electrode spacing.
In a possible implementation manner of the first aspect, the constructing the electrode polarity of the ring electrode includes:
identifying a target ring electrode of ring electrodes connected to a proximal end of the balloon;
starting from the target annular electrode, constructing an electrode serial number of the annular electrode;
And taking positive polarity as a first electrode polarity of a ring electrode corresponding to an odd number in the electrode serial numbers and negative polarity as a second electrode polarity of a ring electrode corresponding to an even number in the electrode serial numbers.
In a possible implementation manner of the first aspect, the constructing a bidirectional asymmetric pulse circuit of the ring electrode based on the electrode polarity includes:
selecting a positive power supply and a negative power supply from the annular electrode;
Respectively constructing a positive parallel switch tube and a negative parallel switch tube of the positive power supply and the negative power supply;
the positive parallel switch tube is communicated with the positive power supply to obtain a first communicated switch tube-power supply, and the negative parallel switch tube is communicated with the negative power supply to obtain a second communicated switch tube-power supply;
And connecting the first communication switching tube-power supply and the second communication switching tube-power supply in series by using a preset resistor to obtain the bidirectional asymmetric pulse circuit.
In a possible implementation manner of the first aspect, the calculating, with the bidirectional asymmetric pulse circuit, an input voltage of the ring electrode includes:
constructing a PID controller of the bidirectional asymmetric pulse circuit;
Detecting the pulse intensity of the bidirectional asymmetric pulse circuit;
feeding back the pulse intensity to the PID controller;
in the PID controller, based on the pulse intensity, an input error corresponding to the ring electrode is calculated using the following formula:
e′(t)＝r(t)-y(u(t))
Wherein e' (T) represents an input error between an input pulse voltage and a pulse intensity of the bidirectional asymmetric pulse circuit, u (T) represents a control signal applied to the ring electrode, T t represents an integration time constant, T D represents a differential time constant, K p represents a proportional gain, e (T) represents an input signal received by the PID controller, an input pulse voltage is initially set, T represents time, r (T) represents an input pulse voltage, and y (u (T)) represents a pulse intensity of the bidirectional asymmetric pulse circuit;
And when the input error accords with a preset error, taking the input pulse voltage corresponding to the input error as the input voltage.
In a second aspect, the present invention provides an electrode construction system for irreversible electroporation pulse ablation, the system comprising:
the line construction module is used for collecting electrode materials of the balloon, identifying uniform elongation rate of the electrode materials and constructing electrode lines of the electrode materials based on the uniform elongation rate;
The quantity selecting module is used for acquiring length data of the saccule and selecting the quantity of the electrodes of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material;
the polarity construction module is used for configuring annular electrodes on the surface of the balloon by utilizing the electrode lines and the electrode quantity to construct the electrode polarity of the annular electrodes;
The voltage calculation module is used for constructing a bidirectional asymmetric pulse circuit of the annular electrode based on the electrode polarity, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit;
and the result determining module is used for driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon.
Compared with the prior art, the technical principle and beneficial effect of this scheme lie in:
According to the embodiment of the invention, the electrode grains of the electrode material are constructed based on the uniform elongation rate so as to realize the purpose of improving the process simplicity by attaching the extension length of the electrode material to the length of the balloon in the inflated state on the premise that other deformation materials are not used and the electrode is separated from the balloon in the process without increasing the process, and further, the target electrode material is selected from the electrode materials based on the uniform elongation rate so as to be used for calculating the length of the electrode material after the electrode material is in a linear and non-grain condition and selecting the electrode material with the largest length after the electrode material is extended from the length based on the double-electrode discharge intensity of the electrode material, in order to select a proper number of electrodes based on the size of the balloon, further, the embodiment of the invention constructs the electrode polarity of the annular electrode to be used for measuring two adjacent electrodes to be constructed as a positive electrode and a negative electrode so that the two electrodes can discharge, and constructs the bidirectional asymmetric pulse circuit of the annular electrode to be used for forming continuous and effective ablation under lower energy based on the electrode polarity and simultaneously can reduce muscle twitches, further, calculates the input voltage of the annular electrode by utilizing the bidirectional asymmetric pulse circuit to be used for adjusting the input pulse voltage of the bidirectional asymmetric pulse circuit based on the pulse intensity generated by the bidirectional asymmetric pulse circuit so as to achieve higher output pulse intensity with lower input pulse voltage, and the PID controller is used for realizing the selection of input voltage, so that the complexity of repeated manual experiments is reduced. Therefore, the electrode construction method and the system for irreversible electroporation pulse ablation provided by the embodiment of the invention can improve the simplicity of the electrode construction process of irreversible electroporation pulse ablation.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
In order to more clearly illustrate the embodiments of the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, and it will be obvious to a person skilled in the art that other drawings can be obtained from these drawings without inventive effort.
FIG. 1 is a schematic flow chart of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the present invention;
FIG. 2a is a schematic view of a radial electrode of an electrode construction method of irreversible electroporation pulse ablation as provided in FIG. 1 in accordance with an embodiment of the present invention;
FIG. 2b is a schematic view of a circumferential electrode of the method for electrode construction for irreversible electroporation pulse ablation according to an embodiment of the present invention;
FIG. 3a is a schematic view of the circumferential electrode polarity of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the present invention;
FIG. 3b is a schematic diagram of radial electrode polarity of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the invention;
FIG. 4 is a schematic diagram of a bi-directional asymmetric pulse circuit of an electrode construction method of irreversible electroporation pulse ablation according to an embodiment of the invention;
FIG. 5 is a schematic block diagram of an electrode construction system for irreversible electroporation pulse ablation according to an embodiment of the present invention;
Detailed Description
It should be understood that the detailed description is presented by way of example only and is not intended to limit the invention.
The embodiment of the invention provides an electrode construction method for irreversible electroporation pulse ablation, and an execution subject of the electrode construction method for irreversible electroporation pulse ablation comprises, but is not limited to, at least one of a server, a terminal and the like which can be configured to execute the method provided by the embodiment of the invention. In other words, the electrode construction method of irreversible electroporation pulse ablation may be performed by software or hardware installed at the terminal device or the server device, the software may be a blockchain platform. The service end includes but is not limited to: a single server, a server cluster, a cloud server or a cloud server cluster, and the like. The server may be an independent server, or may be a cloud server that provides cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, content delivery networks (Content Delivery Network, CDN), and basic cloud computing services such as big data and artificial intelligence platforms.
Referring to fig. 1, a flow chart of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the invention is shown. The electrode construction method for irreversible electroporation pulse ablation depicted in fig. 1 comprises the following steps:
S1, collecting electrode materials of a balloon, identifying uniform elongation of the electrode materials, and constructing electrode lines of the electrode materials based on the uniform elongation.
In the embodiment of the invention, the balloon refers to a balloon catheter, the balloon can be converted from a collapsed state to an expanded state by using a fluid substance or an input pulse voltage, the balloon consists of a cylinder, cones at two ends, a proximal end and a distal end, the input end of the proximal balloon and the distal end represents the output end of the balloon; the electrode material is an electrode material for attaching to the surface of the balloon, and comprises stainless steel, platinum iridium alloy, tungsten carbide and other materials, and the surface of the balloon only needs to be one electrode material of the stainless steel, the platinum iridium alloy, the tungsten carbide and other materials.
Further, in an embodiment of the present invention, the uniform elongation refers to the total elongation of the electrode material at maximum force.
Further, according to the embodiment of the invention, the electrode lines of the electrode material are constructed based on the uniform elongation, so that the extending length of the electrode material is attached to the length of the balloon in an expanded state on the premise that other deformation materials are not used and the electrode is separated from the balloon in a non-increasing process, and the process can achieve the purpose of improving the simplicity of the process.
In an embodiment of the present invention, the constructing the electrode texture of the electrode material based on the uniform elongation includes: selecting a target electrode material from the electrode materials based on the uniform elongation; constructing radial electrode lines of the target electrode material based on the uniform elongation; constructing circumferential electrode lines of the target electrode material based on the uniform elongation; and determining the electrode texture of the electrode material by using the radial electrode texture and the annular electrode texture.
Further, according to the embodiment of the invention, the target electrode material is selected from the electrode materials based on the uniform elongation rate, so that the length of the electrode material after the electrode material is elongated under the condition of being linear and free of lines is calculated, and the electrode material with the largest length after the electrode material is elongated is selected.
In yet another embodiment of the present invention, the selecting a target electrode material from the electrode materials based on the uniform elongation includes: the radial shortest length of the electrode material was calculated using the following formula:
wherein L 1 denotes the radially shortest length, Representing the sum of the cylinder height and the cone height of the balloon when the balloon is not inflated, delta representing the uniform elongation;
the circumferential shortest length of the electrode material was calculated using the following formula:
Wherein L 2 represents the shortest circumferential length, Represents the diameter of the cylindrical bottom surface circle of the balloon when the balloon is not inflated, delta represents the uniform elongation;
calculating the length sum of the radial shortest length and the circumferential shortest length by using the following formula:
L Total (S) ＝L2+L1
Wherein L Total (S) represents the length sum, L 1 represents the radially shortest length, and L 2 represents the circumferentially shortest length;
and taking the length, the middle maximum length and the corresponding electrode material as the target electrode material.
In yet another embodiment of the present invention, the constructing the radial electrode pattern of the target electrode material based on the uniform elongation includes: based on the uniform elongation, the elongation of the electrode material is calculated using the following formula:
ΔL＝δL0
Wherein Δl represents the extension length, L 0 represents the initial length of the electrode material when the balloon is not inflated, δ represents the uniform elongation;
based on the extension length, an initial length of the electrode material is calculated using the following formula:
L＝ΔL+L0
L0＝L-ΔL
wherein L 0 represents the initial length, L represents the sum of the cylinder height and the side length of the cone when the balloon is inflated, and Δl represents the extended length;
Based on the initial length, a length parameter of the electrode material is calculated using the following formula:
f(x)＝Asin(αx+β)
Wherein (α, β) represents a length parameter of the electrode material, f (x) represents a curve function formed by the electrode material when the electrode material is provided with electrode lines, a represents a height, 2 times a represents a width of the electrode material when the electrode material is provided with electrode lines, the width cannot exceed a preset standard width, x represents a coordinate of the electrode material in a horizontal direction, a represents a starting point of the electrode material in the horizontal direction, the starting point is positioned at a dome position of a cone at a near end, and b represents an abscissa of the cone at a far end;
and determining radial electrode lines of the electrode material based on the length parameters.
Optionally, the process of determining the radial electrode texture of the electrode material based on the length parameter is: after the length parameter is determined, a curve function formed by the electrode material when the electrode material is provided with the electrode grains can be determined, so that the electrode grains of the electrode material, namely a curve form formed by the curve function, can be known.
S2, acquiring length data of the balloon, and selecting the electrode number of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material.
In the embodiment of the invention, the length data comprises the height of the cylinder of the balloon and the circumference of the bottom surface circle of the cylinder.
Further, the embodiment of the invention selects the electrode number of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material, so as to select the proper number of electrodes based on the size of the balloon. Wherein, the double-electrode discharge intensity refers to the discharge intensity between the positive electrode and the negative electrode.
In an embodiment of the present invention, the selecting the number of electrodes of the electrode material using the length data based on the discharge intensity of the two electrodes of the electrode material includes: determining an electrode spacing between a positive electrode and a negative electrode in the electrode material based on the double-electrode discharge intensity; based on the cylinder height and the electrode spacing in the length data, the number of circumferential electrodes of the electrode material is calculated using the following formula:
n*l＜＝h
N＝max(n)+1
Wherein N represents the number of the circumferential electrodes, N represents the number of the electrode intervals, l represents the electrode intervals, and h represents the height of the cylinder in the length data;
Based on the bottom surface circumference in the length data and the electrode spacing, the radial electrode number of the electrode material is calculated using the following formula:
m*l＜＝g
M＝max(m)+1
wherein M represents the number of the radial electrodes, M represents the number of the electrode intervals in the radial direction, l represents the electrode intervals, and g represents the circumference of the bottom surface in the length data;
and determining the electrode number of the electrode material by using the circumferential electrode number and the radial electrode number.
In yet another embodiment of the present invention, the determining an electrode spacing between a positive electrode and a negative electrode in the electrode material based on the double electrode discharge intensity includes: based on the discharge intensity of the double electrodes, a relation model between the electrode distance between the positive electrode and the negative electrode in the electrode material and the discharge current between the positive electrode and the negative electrode in the electrode material is constructed by using the following formula:
k＝m1v
v＝m2e
Wherein, Representing the relation model, k representing the electrode spacing, m 1、m2、m3、m4 representing a positive number parameter, v representing a net space volume, k=m 1 v representing that as the electrode spacing increases, the net space volume increases, e representing the double electrode discharge intensity, u representing a jump-in voltage, i representing a discharge current between the positive electrode and the negative electrode in the electrode material;
Constructing a relation curve between the electrode spacing and the discharge current based on the relation model; and taking the electrode spacing corresponding to the maximum discharge current of the discharge currents in the relation curve as the electrode spacing.
S3, configuring annular electrodes on the surface of the balloon by utilizing the electrode lines and the electrode quantity, and constructing electrode polarities of the annular electrodes.
In the embodiment of the invention, the annular electrode comprises a radial electrode and a circumferential electrode, namely, two connected balloons, wherein the first balloon is provided with the radial electrode or the circumferential electrode, and the second balloon is provided with an electrode different from the electrode of the first balloon.
Referring to fig. 2a, fig. 2a is a schematic diagram of a radial electrode of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the invention. In fig. 2a, the watermelon lines represent radial electrodes, and the watermelon lines are attached to the balloon surface.
Referring to fig. 2b, fig. 2b is a schematic diagram of a circumferential electrode of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the invention. In fig. 2b, the watermelon lines represent circumferential electrodes, and the watermelon lines surround the cylindrical portion of the balloon.
Further, the electrode polarity of the annular electrode is constructed so that two adjacent electrodes are constructed as a positive electrode and a negative electrode, and discharge can be conducted between every two electrodes. Wherein the electrode polarities include positive and negative polarities.
Referring to fig. 3a, fig. 3a is a schematic diagram illustrating the polarity of a circumferential electrode in an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the invention. In fig. 3a, positive signs represent positive polarity of the electrodes and negative signs represent negative polarity of the electrodes.
Referring to fig. 3b, fig. 3b is a schematic diagram illustrating a radial electrode polarity of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the invention. In fig. 3b, positive signs represent positive polarity of the electrodes and negative signs represent negative polarity of the electrodes.
In one embodiment of the present invention, the constructing the electrode polarity of the ring electrode includes: identifying a target ring electrode of ring electrodes connected to a proximal end of the balloon; starting from the target annular electrode, constructing an electrode serial number of the annular electrode; and taking positive polarity as a first electrode polarity of a ring electrode corresponding to an odd number in the electrode serial numbers and negative polarity as a second electrode polarity of a ring electrode corresponding to an even number in the electrode serial numbers.
S4, constructing a bidirectional asymmetric pulse circuit of the annular electrode based on the electrode polarity, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit.
The embodiment of the invention constructs the bidirectional asymmetric pulse circuit of the annular electrode based on the electrode polarity for forming continuous and effective ablation at lower energy, and simultaneously can reduce muscle twitch.
Referring to fig. 4, fig. 4 is a schematic diagram of a bidirectional asymmetric pulse circuit of an electrode construction method for irreversible electroporation pulse ablation according to an embodiment of the present invention. In fig. 4, VT1, VT2, VT3, VT4 denote switching transistors, VP denotes a positive power supply, VN denotes a negative power supply, DC denotes direct current, and U0 denotes a voltage across a resistor.
In an embodiment of the present invention, the constructing the bidirectional asymmetric pulse circuit of the ring electrode based on the electrode polarity includes: selecting a positive power supply and a negative power supply from the annular electrode; respectively constructing a positive parallel switch tube and a negative parallel switch tube of the positive power supply and the negative power supply; the positive parallel switch tube is communicated with the positive power supply to obtain a first communicated switch tube-power supply, and the negative parallel switch tube is communicated with the negative power supply to obtain a second communicated switch tube-power supply; and connecting the first communication switching tube-power supply and the second communication switching tube-power supply in series by using a preset resistor to obtain the bidirectional asymmetric pulse circuit.
The positive power supply and the negative power supply are composed of a positive electrode and a negative electrode, and the difference is that the positive electrode and the negative electrode of the positive power supply are different from the positive electrode and the negative electrode of the negative power supply.
Further, the embodiment of the invention calculates the input voltage of the ring electrode by using the bidirectional asymmetric pulse circuit, so as to adjust the input pulse voltage of the bidirectional asymmetric pulse circuit based on the pulse intensity generated by the bidirectional asymmetric pulse circuit, so that the input pulse voltage reaches higher output pulse intensity with lower input pulse voltage, and the PID controller is used for realizing the selection of the input voltage, thereby reducing the complexity of manual repeated experiments.
In an embodiment of the present invention, the calculating the input voltage of the ring electrode using the bi-directional asymmetric pulse circuit includes: constructing a PID controller of the bidirectional asymmetric pulse circuit; detecting the pulse intensity of the bidirectional asymmetric pulse circuit; feeding back the pulse intensity to the PID controller; in the PID controller, based on the pulse intensity, an input error corresponding to the ring electrode is calculated using the following formula:
e′(t)＝r(t)-y(u(t))
Wherein e' (T) represents an input error between an input pulse voltage and a pulse intensity of the bidirectional asymmetric pulse circuit, u (T) represents a control signal applied to the ring electrode, T t represents an integration time constant, T D represents a differential time constant, K p represents a proportional gain, e (T) represents an input signal received by the PID controller, an input pulse voltage is initially set, T represents time, r (T) represents an input pulse voltage, and y (u (T)) represents a pulse intensity of the bidirectional asymmetric pulse circuit;
And when the input error accords with a preset error, taking the input pulse voltage corresponding to the input error as the input voltage.
The preset error is set to 0, and when the error between the input pulse voltage and the pulse intensity of the bidirectional asymmetric pulse circuit is 0, the input pulse voltage can output standard pulse intensity.
S5, driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon.
It can be seen that, according to the embodiment of the present invention, the electrode texture of the electrode material is constructed based on the uniform elongation rate, so that the electrode material is attached to the balloon length in the inflated state without using other deformation materials and without increasing the process to separate the electrode from the balloon, and the process can achieve the purpose of improving the simplicity of the process, further, according to the embodiment of the present invention, the target electrode material is selected from the electrode materials based on the uniform elongation rate, so that the length of the electrode material after the electrode material is extended in a linear and non-textured condition is calculated, the electrode material with the largest length after the electrode material is selected therefrom, further, according to the embodiment of the present invention, the electrode number of the electrode material is selected by using the length data based on the double electrode discharge intensity of the electrode material, in order to select a proper number of electrodes based on the size of the balloon, further, the embodiment of the invention constructs the electrode polarity of the annular electrode to be used for measuring two adjacent electrodes to be constructed as a positive electrode and a negative electrode so that the two electrodes can discharge, and constructs the bidirectional asymmetric pulse circuit of the annular electrode to be used for forming continuous and effective ablation under lower energy based on the electrode polarity and simultaneously can reduce muscle twitches, further, calculates the input voltage of the annular electrode by utilizing the bidirectional asymmetric pulse circuit to be used for adjusting the input pulse voltage of the bidirectional asymmetric pulse circuit based on the pulse intensity generated by the bidirectional asymmetric pulse circuit so as to achieve higher output pulse intensity with lower input pulse voltage, and the PID controller is used for realizing the selection of input voltage, so that the complexity of repeated manual experiments is reduced. Therefore, the electrode construction method for irreversible electroporation pulse ablation provided by the embodiment of the invention can promote the simplicity of the electrode construction process of irreversible electroporation pulse ablation.
As shown in FIG. 5, a functional block diagram of an electrode construction system for irreversible electroporation pulse ablation according to the present invention is shown.
The electrode construction system 500 of irreversible electroporation pulse ablation according to the invention may be installed in an electronic device. Depending on the function implemented, the electrode construction system of irreversible electroporation pulse ablation may include a texture construction module 501, a quantity selection module 502, a polarity construction module 503, a voltage calculation module 504, and a result determination module 505. The module of the invention, which may also be referred to as a unit, refers to a series of computer program segments, which are stored in the memory of the electronic device, capable of being executed by the processor of the electronic device and of performing a fixed function.
In the embodiment of the present invention, the functions of each module/unit are as follows:
The texture construction module 501 is configured to collect electrode materials of a balloon, identify a uniform elongation rate of the electrode materials, and construct electrode textures of the electrode materials based on the uniform elongation rate;
The number selecting module 502 is configured to collect length data of the balloon, and select the number of electrodes of the electrode material based on the double-electrode discharge intensity of the electrode material by using the length data;
the polarity construction module 503 is configured to configure an annular electrode on the surface of the balloon by using the electrode lines and the electrode number, so as to construct an electrode polarity of the annular electrode;
The voltage calculation module 504 is configured to construct a bidirectional asymmetric pulse circuit of the ring electrode based on the electrode polarity, and calculate an input voltage of the ring electrode using the bidirectional asymmetric pulse circuit;
The result determining module 505 is configured to drive the ring electrode by using the input voltage, obtain a driven ring electrode, and use the driven ring electrode as an electrode construction result of the balloon.
In detail, the modules in the electrode construction system 500 for irreversible electroporation pulse ablation according to the embodiment of the present invention use the same technical means as the electrode construction method for irreversible electroporation pulse ablation described in fig. 1 to 4 and can produce the same technical effects, which are not described herein.
The present invention also provides a storage medium storing a computer program which, when executed by a processor of an electronic device, can implement:
Collecting electrode materials of the saccule, identifying uniform elongation rate of the electrode materials, and constructing electrode lines of the electrode materials based on the uniform elongation rate;
Acquiring length data of the balloon, and selecting the electrode quantity of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material;
Using the electrode lines and the electrode quantity, configuring annular electrodes on the surface of the saccule, and constructing electrode polarities of the annular electrodes;
based on the electrode polarity, constructing a bidirectional asymmetric pulse circuit of the annular electrode, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit;
And driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon.
The foregoing is only a specific embodiment of the invention to enable those skilled in the art to understand or practice the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A method of electrode construction for irreversible electroporation pulse ablation, the method comprising:
Collecting electrode materials of the saccule, identifying uniform elongation rate of the electrode materials, and constructing electrode lines of the electrode materials based on the uniform elongation rate;
Acquiring length data of the balloon, and selecting the electrode quantity of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material;
Using the electrode lines and the electrode quantity, configuring annular electrodes on the surface of the saccule, and constructing electrode polarities of the annular electrodes;
based on the electrode polarity, constructing a bidirectional asymmetric pulse circuit of the annular electrode, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit;
And driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon.
2. The method of claim 1, wherein the constructing an electrode texture of the electrode material based on the uniform elongation comprises:
Selecting a target electrode material from the electrode materials based on the uniform elongation;
Constructing radial electrode lines of the target electrode material based on the uniform elongation;
Constructing circumferential electrode lines of the target electrode material based on the uniform elongation;
And determining the electrode texture of the electrode material by using the radial electrode texture and the annular electrode texture.
3. The method of claim 2, wherein the selecting a target electrode material from the electrode materials based on the uniform elongation comprises:
calculating the radial shortest length of the electrode material:
Calculating the circumferential shortest length of the electrode material:
calculating the length sum of the radial shortest length and the circumferential shortest length:
and taking the length, the middle maximum length and the corresponding electrode material as the target electrode material.
4. The method of claim 2, wherein the constructing a radial electrode texture of the target electrode material based on the uniform elongation comprises:
Calculating an extension length of the electrode material based on the uniform elongation:
calculating an initial length of the electrode material based on the extension length;
Based on the initial length, a length parameter of the electrode material is calculated using the following formula:
f(x)＝Asin(αx+β)
；
Wherein (α, β) represents a length parameter of the electrode material, f (x) represents a curve function formed by the electrode material when the electrode material is provided with electrode lines, a represents a height, 2 times a represents a width of the electrode material when the electrode material is provided with electrode lines, the width cannot exceed a preset standard width, x represents a coordinate of the electrode material in a horizontal direction, a represents a starting point of the electrode material in the horizontal direction, the starting point is positioned at a dome position of a cone at a near end, and b represents an abscissa of the cone at a far end;
and determining radial electrode lines of the electrode material based on the length parameters.
5. The method of claim 2, wherein the selecting the number of electrodes of the electrode material using the length data based on the two-electrode discharge intensity of the electrode material comprises:
Determining an electrode spacing between a positive electrode and a negative electrode in the electrode material based on the double-electrode discharge intensity;
Spacing the electrode from the cylinder based on the cylinder height in the length data;
spacing the electrode from the bottom surface circumference based on the length data;
and determining the electrode number of the electrode material by using the circumferential electrode number and the radial electrode number.
6. The method of claim 5, wherein the determining an electrode spacing between a positive electrode and a negative electrode in the electrode material based on the double electrode discharge intensity comprises:
based on the discharge intensity of the double electrodes, a relation model between the electrode distance between the positive electrode and the negative electrode in the electrode material and the discharge current between the positive electrode and the negative electrode in the electrode material is constructed by using the following formula:
k＝m1v
v＝m2e
；
；
；
Wherein, Representing the relation model, k representing the electrode spacing, m 1、m2、m3、m4 representing a positive number parameter, v representing a net space volume, k=m 1 v representing that as the electrode spacing increases, the net space volume increases, e representing the double electrode discharge intensity, u representing a jump-in voltage, i representing a discharge current between the positive electrode and the negative electrode in the electrode material;
constructing a relation curve between the electrode spacing and the discharge current based on the relation model;
And taking the electrode spacing corresponding to the maximum discharge current of the discharge currents in the relation curve as the electrode spacing.
7. The method of claim 1, wherein said constructing an electrode polarity of said ring electrode comprises:
identifying a target ring electrode of ring electrodes connected to a proximal end of the balloon;
starting from the target annular electrode, constructing an electrode serial number of the annular electrode;
And taking positive polarity as a first electrode polarity of a ring electrode corresponding to an odd number in the electrode serial numbers and negative polarity as a second electrode polarity of a ring electrode corresponding to an even number in the electrode serial numbers.
8. The method of claim 1, wherein said constructing a bi-directional asymmetric pulsing circuit for said ring electrode based on said electrode polarity comprises:
selecting a positive power supply and a negative power supply from the annular electrode;
Respectively constructing a positive parallel switch tube and a negative parallel switch tube of the positive power supply and the negative power supply;
the positive parallel switch tube is communicated with the positive power supply to obtain a first communicated switch tube-power supply, and the negative parallel switch tube is communicated with the negative power supply to obtain a second communicated switch tube-power supply;
And connecting the first communication switching tube-power supply and the second communication switching tube-power supply in series by using a preset resistor to obtain the bidirectional asymmetric pulse circuit.
9. The method of claim 1, wherein said calculating an input voltage of said ring electrode using said bi-directional asymmetric pulse circuit comprises:
constructing a PID controller of the bidirectional asymmetric pulse circuit;
Detecting the pulse intensity of the bidirectional asymmetric pulse circuit;
feeding back the pulse intensity to the PID controller;
in the PID controller, based on the pulse intensity, an input error corresponding to the ring electrode is calculated using the following formula:
；
e′(t)＝r(t)-y(u(t))
Wherein e' (T) represents an input error between an input pulse voltage and a pulse intensity of the bidirectional asymmetric pulse circuit, u (T) represents a control signal applied to the ring electrode, T t represents an integration time constant, T D represents a differential time constant, K p represents a proportional gain, e (T) represents an input signal received by the PID controller, an input pulse voltage is initially set, T represents time, r (T) represents an input pulse voltage, and y (u (T)) represents a pulse intensity of the bidirectional asymmetric pulse circuit;
And when the input error accords with a preset error, taking the input pulse voltage corresponding to the input error as the input voltage.
10. An electrode construction system for irreversible electroporation pulse ablation according to any of claims 1-9, wherein the system comprises:
the line construction module is used for collecting electrode materials of the balloon, identifying uniform elongation rate of the electrode materials and constructing electrode lines of the electrode materials based on the uniform elongation rate;
The quantity selecting module is used for acquiring length data of the saccule and selecting the quantity of the electrodes of the electrode material by utilizing the length data based on the double-electrode discharge intensity of the electrode material;
the polarity construction module is used for configuring annular electrodes on the surface of the balloon by utilizing the electrode lines and the electrode quantity to construct the electrode polarity of the annular electrodes;
The voltage calculation module is used for constructing a bidirectional asymmetric pulse circuit of the annular electrode based on the electrode polarity, and calculating the input voltage of the annular electrode by using the bidirectional asymmetric pulse circuit;
and the result determining module is used for driving the annular electrode by using the input voltage to obtain a driving annular electrode, and taking the driving annular electrode as an electrode construction result of the balloon.
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