CN117137726A - Collagen repair patch and preparation method thereof - Google Patents
Collagen repair patch and preparation method thereof Download PDFInfo
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- CN117137726A CN117137726A CN202311402258.XA CN202311402258A CN117137726A CN 117137726 A CN117137726 A CN 117137726A CN 202311402258 A CN202311402258 A CN 202311402258A CN 117137726 A CN117137726 A CN 117137726A
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 86
- 108010035532 Collagen Proteins 0.000 title claims abstract description 86
- 229920001436 collagen Polymers 0.000 title claims abstract description 86
- 230000008439 repair process Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title description 8
- 238000003860 storage Methods 0.000 claims abstract description 90
- 238000003825 pressing Methods 0.000 claims abstract description 35
- 239000010410 layer Substances 0.000 claims description 126
- 238000002955 isolation Methods 0.000 claims description 32
- 238000013461 design Methods 0.000 claims description 21
- 239000012790 adhesive layer Substances 0.000 claims description 16
- 239000002985 plastic film Substances 0.000 claims description 15
- 238000010030 laminating Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 239000000512 collagen gel Substances 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000005253 cladding Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 4
- 238000013329 compounding Methods 0.000 claims description 4
- 238000005538 encapsulation Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005451 protein repair Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00795—Plasters special helping devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00906—Plasters containing means for transcutaneous or transdermal drugs application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to the technical field of collagen repair patches, in particular to a collagen repair patch, which comprises the following components: the PET structure layer is characterized in that a storage bag is stuck at the bottom of the PET structure layer in a limiting manner, a collagen layer is encapsulated in the storage bag, the bottom of the storage bag is designed to be a porous medium layer, and an assembly space is formed between the bottom of the PET structure layer and the top of the storage bag; the top of the PET structural layer above the assembly space is provided with a pressing part which deforms downwards to enable the collagen layer inside the storage bag to circulate downwards through the porous medium layer; the bottom of the storage bag is designed with a plurality of layers of permeable layers, flexible assembly strips are arranged on two sides of each permeable layer, and the two flexible assembly strips are semi-coated on the outer part of the storage bag.
Description
Technical Field
The invention relates to the technical field of protein repair patches, in particular to a collagen repair patch and a preparation method thereof.
Background
The collagen repair patch is a patch type repair patch taking collagen as a main component, and by utilizing the biocompatibility and degradability of the collagen, the collagen interacts with the collagen of a human body to stimulate proliferation and secretion of fibroblasts, promote synthesis and arrangement of new collagen and accelerate healing and remodeling of a wound surface.
In the prior art, the collagen repair patch is formed into a film shape by using collagen, then the film-shaped or sheet-shaped collagen patch is packaged in a packaging bag, and is taken out when needed to be used and then directly applied to a wound surface or a to-be-repaired position, but the mode requires a user to keep a posture, and the film-shaped collagen patch keeps the fit with the skin or the wound surface by relying on an aqueous substance dissolved by the user, so that the use time and the environment are limited, and the stability is poor.
Disclosure of Invention
The invention provides a collagen repair patch and a preparation method thereof, which can repair the wound surface or the peripheral part of the wound surface by applying a collagen layer, and can maintain the use stability and increase the use range of the collagen patch by utilizing a flexible assembly strip.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a collagen repair patch comprising:
the PET structure layer is characterized in that a storage bag is stuck at the bottom of the PET structure layer in a limiting manner, a collagen layer is encapsulated in the storage bag, the bottom of the storage bag is designed to be a porous medium layer, and an assembly space is formed between the bottom of the PET structure layer and the top of the storage bag; the top of the PET structural layer above the assembly space is provided with a pressing part which deforms downwards to enable the collagen layer inside the storage bag to circulate downwards through the porous medium layer; the bottom design of storage bag has the multilayer permeable layer, flexible assembly strip is all installed to the permeable layer both sides, two flexible assembly strip half cladding is in the outside of storage bag, is located the part of storage bag top flexible assembly strip is the folding design of gyration, and stores in the assembly space, two the tip of flexible assembly strip has the spacing design of adhesion.
Preferably, the two flexible assembly strips are symmetrically designed, one end of each flexible assembly strip is connected with the permeable layer, one end of each flexible assembly strip is coated on the outer wall of the storage bag and extends to the top of the storage bag, the other end of each flexible assembly strip extends to the top of the storage bag and then is turned and folded to penetrate out of the assembly space, and an air-permeable space is reserved between the turning and folding positions of the two flexible assembly strips.
Preferably, the two flexible assembly strips are asymmetrically designed, but the two flexible assembly strips are respectively connected with two sides of the permeable layer, one longer flexible assembly strip is coated on the outer wall of the storage bag, and the rotary folding part of the flexible assembly strip above the storage bag is completely covered on the top of the storage bag.
Preferably, the rotary folding part of the flexible assembly strip is filled with a sandwich plate, the outer wall of the rotary folding part of the flexible assembly strip is tightly attached to the sandwich plate, a first adhesive layer is embedded in the outer wall of the rotary folding part of the flexible assembly strip, a release film is attached to the outer wall of the sandwich plate, the release film corresponds to the first adhesive layer, a rough layer is designed on the flexible assembly strip, and the first adhesive layer can be pulled to adhere to the rough layer after being pulled out.
Preferably, the pressing part comprises a flexible pressing layer designed at the top of the PET structural layer, the material of the flexible pressing layer is harder than that of the PET structural layer, the flexible pressing layer has the deformation resetting capacity, the bottom of the flexible pressing layer is connected with an isolation pressing plate in a clamping mode, the bottom of the isolation pressing plate is located in an assembly space, and a plurality of isolation holes are designed in the isolation pressing plate.
Preferably, laminating portion is installed to the both sides of storage bag, laminating portion is connected with the bottom of PET structural layer, laminating portion does not interfere the work of flexible assembly strip, is located two laminating portion outsides the bottom design on PET structural layer has the second adhesive layer.
Preferably, the water-blocking ring is embedded and installed on the lowest permeable layer, the water-blocking ring is made of waterproof deformable materials, and the water-blocking ring is of an end-to-end closed structure.
Preferably, an isolating plastic sheet is stuck on the outer wall of the flexible assembly strip below the storage bag, and the isolating plastic sheet seals the permeable layer.
A preparation method of a collagen repair patch comprises the following steps:
step one: preparing a collagen gel sheet from the collagen solution, and packaging the collagen gel sheet into a storage bag by a packaging machine;
step two: the storage bag and the PET structural layer are compositely fixed by using a thermal bonding technology, and meanwhile, an assembly space is formed between the top of the storage bag and the bottom of the PET structural layer;
step three: wrapping the flexible assembly strip on the top of the storage bag and enabling the flexible assembly strip to be in a rotary folding state, wherein the rotary folding part is positioned in the assembly space;
step four: and the bottom of the storage bag is compounded with a plurality of permeable layers through a compounding technology, and meanwhile, an isolation plastic sheet is attached to the outer wall of the permeable layer at the lowest layer, so that the isolation plastic sheet and the flexible assembly strip are in tearable connection.
Preferably, in the third step, the method further comprises embedding a designed pressing part at the top of the PET structural layer, and assembling an isolation pressing plate below the pressing part, so that the isolation pressing plate can apply pressure to the inside of the storage bag, and ventilation of the repair part can be ensured through an assembling space after the storage bag is reset.
The invention provides a collagen repair patch and a preparation method thereof, wherein collagen is prepared into collagen sheets or gel, and the collagen sheets or gel are stored in a storage bag, when the collagen repair patch is required to be used, two flexible assembly strips are required to be pulled out outwards, and as the collagen repair patch is in a rotary folding state, the outwards extending parts can be long enough, and meanwhile, the storage bag is fixed by using the adhesive design of the end parts of the two flexible assembly strips, at the moment, the collagen in the storage bag can be penetrated downwards by a porous medium layer under pressure through the cooperation of a pressing part and the storage bag, so that the collagen can be applied and repaired to a wound surface or the peripheral part of the wound surface, the stability of the collagen can be kept by using the flexible assembly strips, and the collagen repair patch can be effectively fixed in a special position by arranging the extending capacity of the two flexible assembly strips, so that the collagen layer can be better coated on the wound surface, and can be used in other complex parts such as a thigh part, a foot part and the like.
Drawings
FIG. 1 is a schematic view of an external perspective structure of the present invention;
FIG. 2 is a schematic perspective view of another view of the present invention;
FIG. 3 is a schematic diagram of the front view of FIG. 1 according to the present invention;
FIG. 4 is a schematic view of the structure of FIG. 3 taken along line A-A in accordance with the present invention;
FIG. 5 is a schematic view of the structure of the present invention;
FIG. 6 is a schematic view of the structure of the present invention in another view;
fig. 7 is a schematic structural view of a second embodiment of a flexible mounting strip according to the present invention.
In the figure: 1. a PET structural layer; 2. soft pressing layer; 3. a flexible mounting strip; 4. isolating the plastic sheet; 5. a storage bag; 6. a collagen layer; 7. an isolation pressing plate; 8. a sandwich panel; 9. a first adhesive layer; 11. a water blocking ring; 12. a permeation layer; 13. a rough layer; 14. a bonding part; 15. and a second adhesive layer.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1 to 7, the present invention provides a collagen repair patch, comprising:
the PET structure layer 1, the bottom of the PET structure layer 1 is limited and stuck with a storage bag 5, the inside of the storage bag 5 is encapsulated with a collagen layer 6, the bottom of the storage bag 5 is designed into a porous medium layer, and an assembly space is formed between the bottom of the PET structure layer 1 and the top of the storage bag 5; the top of the PET structural layer 1 above the assembly space is provided with a pressing part, and the pressing part deforms downwards to enable the collagen layer 6 inside the storage bag 5 to circulate downwards through the porous medium layer; the bottom design of storage bag 5 has multilayer permeable layer 12, and flexible assembly strip 3 is all installed to permeable layer 12 both sides, and two flexible assembly strips 3 partly wrap up in the outside of storage bag 5, and the partly flexible assembly strip 3 that is located storage bag 5 top is the folding design of gyration, and stores in the assembly space, and the tip of two flexible assembly strips 3 has the spacing design of adhesion.
In the prior art, collagen is directly taken out from a packaging bag, and then the collagen is attached to the skin at a wound surface by means of dissolved water-based substances, but the mode needs a user to keep a stable posture, so that the displacement of a collagen film is avoided, the use is influenced, and when the wound surface to be repaired is positioned at a position of the skin with no good arc surface such as a joint or a hand, the attaching stability of the collagen is poorer, and the normal contraction or use of the joint or the hand is influenced, in the invention, the collagen is prepared into collagen sheets or gel, and simultaneously stored in the storage bag 5, and when the collagen is needed to be used, the two flexible assembly strips 3 are required to be pulled out outwards, and because the collagen sheets or the collagen sheets are in a rotary folding state, the collagen sheets or the collagen sheets can be repaired by the adhesive design of the ends of the two flexible assembly strips 3, and the storage bag 5 is fixed, at the same time, the collagen sheets 6 in the storage bag 5 can be penetrated downwards under pressure through a porous medium layer by the cooperation of the pressing part and the storage bag 5, so that the collagen sheets or the peripheral parts of the wound surface can be repaired by the flexible assembly strips 3, and the collagen sheets can be repaired by the peripheral flexible assembly strips.
Furthermore, the assembly space between the top of the storage bag 5 and the PET structural layer 1 may provide an air-ventilated environment.
The thickness of the porous medium layer is thinner, so that the porous medium layer can be damaged when the pressure is too high, and the collagen layer 6 is in a free state at the moment, so that the porous medium layer can be used for a long time without repeated extrusion when being used.
The following provides two swivel embodiments of the flexible mounting strip 3. :
example 1: the symmetrical design of two flexible assembly strips 3, the one end of flexible assembly strip 3 is connected with permeable layer 12, and the one end cladding of flexible assembly strip 3 just extends to its top on the outer wall of storage bag 5, the flexible assembly strip 3 other end extends to storage bag 5 top back gyration folding wears out the assembly space, leave ventilative space between the gyration folding department of two flexible assembly strips 3, please refer to fig. 3 and fig. 4, this embodiment is when using, pull out two flexible assembly strips 3 outwards, make two flexible assembly strips 3 all can outwards extend, then realize spacing fixed to storage bag 5 and collagen layer 6 through utilizing the adhesion design, thereby improve the stability of collagen restoration subsides, secondly, two flexible assembly strips 3, the ventilative space of formation between storage bag 5 and the PET structural layer 1, can ensure to paste under not pasting through flexible assembly strip 3 and adopting other modes, after flexible press layer 2 exports collagen layer 6 downwards under the effect of pressing part, ventilative space can use, improve the use of protein restoration subsides, specific use performance of pasting is realized through utilizing flexible assembly strip 3 to take out the flexible operation, then take advantage of flexible assembly strip 3 to take out the flexible assembly strip and flexible assembly layer 3 and flexible assembly cover, then take advantage of the flexible assembly strip subsides to take out the flexible assembly of the flexible assembly strip and take advantage of the flexible assembly strip is convenient for, and the flexible assembly line is formed.
Example 2: in this embodiment, please refer to fig. 7, through making the flexible assembly strip 3 completely cover the top of the storage bag 5, the full cladding of the storage bag 5 can be realized, thereby promoting the unidirectional extension length of the flexible assembly strip 3, when operating, the collagen repair patch is pressed, only the flexible assembly strip 3 at the longer end needs to be drawn out, then the flexible assembly strip 3 is fixed with the skin or the flexible assembly strip 3 at the other end by using the adhesion design, and the length can meet the requirement of complex winding and pasting of joints or hands, thereby more effectively fixing the collagen repair patch at a special position, improving the stability, making the collagen layer 6 better clad on the wound surface, and further enabling the collagen repair patch to be used in the thigh, foot and other positions.
On the basis of the first embodiment and the second embodiment, the rotary folding position of the flexible assembly strip 3 is filled with the sandwich plate 8, the outer wall of the rotary folding position of the flexible assembly strip 3 is tightly attached to the sandwich plate 8, the outer wall of the rotary folding position of the flexible assembly strip 3 is embedded and designed with the first adhesive layer 9, the outer wall of the sandwich plate 8 is attached with the release film, the release film corresponds to the first adhesive layer 9, the other flexible assembly strip 3 is designed with the rough layer 13, the first adhesive layer 9 can be pulled to adhere to the rough layer 13 after being pulled out, please refer to fig. 3 and the detailed enlarged view and fig. 7 thereof, in the embodiment, the sandwich plate 8 at the rotary folding position can be also taken out in the process of pulling out or pulling out the flexible assembly strip 3, meanwhile, the release film and the first adhesive layer 9 can be staggered to release the relation, and then the first adhesive layer 9 can be directly used for adhering the flexible assembly strip 3 to the skin or the rough layer 13 on the other flexible assembly strip 3, wherein the first layer 9 can be made of rubber or silica gel and other materials with certain hardness, the adhesive can be slightly deformed and can be repaired under the condition of maintaining the special shaping of collagen.
On the basis of embodiment one and embodiment two, the pressing part includes the gentle layer 2 of pressing of design at PET structural layer 1 top, the material of gentle layer 2 is hard in the material of PET structural layer 1, and gentle layer 2 possesses the ability that deformation resets, the bottom joint of gentle layer 2 has isolation clamp plate 7, isolation clamp plate 7 is located the assembly space in the bottom, a plurality of isolation holes have been designed on the isolation clamp plate 7, please see fig. 3 and fig. 4, in this embodiment, through setting up isolation clamp plate 7, it can be as the intermediary to carry out hard exerting pressure to storage bag 5, form the cooperation between it and sandwich plate 8 simultaneously, ensure collagen repair paste's overall form, secondly, it is after having destroyed storage bag 5, because PET structural layer 1 carries out the joint to isolation clamp plate 7 through its flexible characteristic, make its isolation clamp plate 7 be located the bottom of gentle layer 2, in the in-process of pressing of gentle layer 2, isolation clamp plate 7 can take place to break away from this moment, isolation clamp plate 7 can break away from the soft layer 2 and imbeds to storage bag 5, can also avoid polluting the collagen inside layer 6 to the outside on isolation hole on isolation clamp plate 7 simultaneously.
On the basis of the first embodiment and the second embodiment, the attaching parts 14 are installed on two sides of the storage bag 5, the attaching parts 14 are connected with the bottom of the PET structural layer 1, the attaching parts 14 do not interfere with the operation of the flexible assembly strips 3, the second adhesive layer 15 is designed at the bottom of the PET structural layer 1 outside the two attaching parts 14, the connection between the PET structural layer 1 and the storage bag 5 can be ensured by arranging the attaching parts 14, meanwhile, a space can be reserved between the storage bag 5 and the PET structural layer 1, the PET structural layer 1 can be used as primary limiting fixation, after the PET structural layer 1 is adhered with the skin, the flexible assembly strips 3 can be simultaneously fixed in a crossed manner after the hand or other parts are wound and adhered, and the stability of the collagen repair paste can be controlled to a greater extent.
On the basis of the first embodiment and the second embodiment, the water-blocking ring 11 is embedded and installed on the lowermost permeable layer 12, the water-blocking ring 11 is made of waterproof deformable material, the water-blocking ring 11 is of an end-to-end closed structure, please refer to fig. 6, in this embodiment, by arranging the water-blocking ring 11, external dirt, solution or sweat can be prevented from flowing into the permeable layer 12, so that the permeable layer 12 is blocked, and the permeation efficiency of the collagen layer 6 is affected.
Further, be located and paste on the outer wall of flexible assembly strip 3 of storage bag 5 below and keep apart plastic sheet 4, keep apart plastic sheet 4 and seal permeable layer 12, through setting up and keep apart plastic sheet 4, be convenient for protect permeable layer 12, tear apart plastic sheet 4 when needs use and can aim at permeable layer 12 and surface of a wound.
A preparation method of a collagen repair patch comprises the following steps:
step one: preparing a collagen gel sheet from the collagen solution, and packaging the collagen gel sheet into the storage bag 5 by a packaging machine;
step two: the storage bag 5 and the PET structural layer 1 are compositely fixed by using a thermal bonding technology, and meanwhile, an assembly space is formed between the top of the storage bag 5 and the bottom of the PET structural layer 1;
step three: wrapping the flexible assembly strip 3 on top of the storage bag 5 and enabling the flexible assembly strip to be in a rotary folding state, wherein the rotary folding part is positioned in the assembly space;
step four: and a plurality of permeable layers 12 are compounded at the bottom of the storage bag 5 through a compounding technology, and meanwhile, the isolation plastic sheet 4 is attached to the outer wall of the permeable layer 12 at the lowest layer, so that the isolation plastic sheet 4 and the flexible assembly strip 3 are in tearable connection.
Further, in step three, still include at the top embedding design pressing part of PET structural layer 1, simultaneously at pressing part below assembly isolation clamp plate 7, make isolation clamp plate 7 can exert pressure to the inside of storage bag 5, can ensure the ventilative of restoration department through the assembly space after storage bag 5 resets simultaneously, can accomplish the preparation of collagen restoration subsides through above-mentioned step, can improve the application range and the spacing effect of collagen restoration subsides through increasing flexible assembly strip 3.
By utilizing the cooperation of the above-mentioned isostructure, can compress the restoration to the surface of a wound or its peripheral part through collagen layer 6, can utilize flexible assembly strip 3 to keep the stability in use and increase application range of collagen subsides simultaneously.
The standard components used in the present embodiment may be purchased directly from the market, but the nonstandard structural components according to the descriptions of the specification and the drawings may also be obtained by unambiguous processing according to the conventional technical knowledge, and meanwhile, the connection manner of each component adopts the conventional means mature in the prior art, and the machinery, the components and the equipment all adopt the conventional types in the prior art, so that the specific description will not be made here.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A collagen repair patch, which is characterized in that: comprising the following steps:
the PET structure layer (1), the bottom of PET structure layer (1) is spacing to paste has storage bag (5), the inside encapsulation of storage bag (5) has collagen layer (6), the bottom of storage bag (5) designs to porous medium layer, form the assembly space between PET structure layer (1) bottom and storage bag (5) top;
the top of the PET structural layer (1) above the assembly space is provided with a pressing part which deforms downwards to enable the collagen layer (6) in the storage bag (5) to circulate downwards through the porous medium layer;
the bottom design of storage bag (5) has multilayer permeable layer (12), flexible assembly strip (3) are all installed to permeable layer (12) both sides, two flexible assembly strip (3) half cladding is in the outside of storage bag (5), is located the part of storage bag (5) top flexible assembly strip (3) are gyration folding design, and store in the assembly space, two the tip of flexible assembly strip (3) has the spacing design of adhesion.
2. The collagen repair patch according to claim 1, wherein: two flexible assembly strip (3) symmetrical design, the one end of flexible assembly strip (3) is connected with permeable layer (12), just the one end cladding of flexible assembly strip (3) just extends its top on the outer wall of storage bag (5), the other end of flexible assembly strip (3) extends to the storage bag (5) top back returns and folds and wear out the assembly space, two leave ventilative space between the gyration folding department of flexible assembly strip (3).
3. The collagen repair patch according to claim 1, wherein: two flexible assembly strips (3) are asymmetrically designed, but the two flexible assembly strips (3) are respectively connected with two sides of the permeable layer (12), one longer one end of each flexible assembly strip (3) is coated on the outer wall of the storage bag (5), and the rotary folding part of each flexible assembly strip (3) above the storage bag (5) is completely covered on the top of the storage bag (5).
4. A collagen repair patch according to claim 2 or 3, wherein: the flexible assembly strip (3) is characterized in that a sandwich plate (8) is filled at a rotary folding position of the flexible assembly strip (3), the outer wall of the rotary folding position of the flexible assembly strip (3) is tightly attached to the sandwich plate (8), a first adhesive layer (9) is embedded in the outer wall of the rotary folding position of the flexible assembly strip (3), a release film is attached to the outer wall of the sandwich plate (8), the release film corresponds to the first adhesive layer (9), a rough layer (13) is designed on the flexible assembly strip (3), and the first adhesive layer (9) can be pulled to be adhered to the rough layer (13) after being pulled out.
5. The collagen repair patch according to claim 4, wherein: the pressing part comprises a flexible pressing layer (2) designed at the top of the PET structural layer (1), the material of the flexible pressing layer (2) is harder than that of the PET structural layer (1), the flexible pressing layer (2) has deformation resetting capacity, an isolation pressing plate (7) is clamped at the bottom of the flexible pressing layer (2), the bottom of the isolation pressing plate (7) is located an assembly space, and a plurality of isolation holes are designed in the isolation pressing plate (7).
6. The collagen repair patch according to claim 4, wherein: laminating portion (14) are installed to both sides of storage bag (5), laminating portion (14) are connected with the bottom of PET structural layer (1), laminating portion (14) do not interfere the work of flexible assembly strip (3), are located two laminating portion (14) outsides the bottom design of PET structural layer (1) has second adhesive layer (15).
7. The collagen repair patch according to claim 4, wherein: the water blocking ring (11) is embedded and installed on the lowest permeable layer (12), the water blocking ring (11) is made of waterproof deformable materials, and the water blocking ring (11) is of an end-to-end closed structure.
8. The collagen repair patch according to claim 7, wherein: an isolating plastic sheet (4) is stuck on the outer wall of the flexible assembly strip (3) below the storage bag (5), and the isolating plastic sheet (4) seals the permeable layer (12).
9. The method for preparing a collagen repair patch according to claim 5, wherein: the method comprises the following steps:
step one: preparing a collagen gel sheet from the collagen solution, and packaging the collagen gel sheet into a storage bag (5) by a packaging machine;
step two: the storage bag (5) and the PET structural layer (1) are compositely fixed by using a thermal bonding technology, and meanwhile, an assembly space is formed between the top of the storage bag (5) and the bottom of the PET structural layer (1);
step three: the flexible assembly strip (3) is wrapped on the top of the storage bag (5) and is in a rotary folding state, and the rotary folding part is positioned in the assembly space;
step four: and (3) compounding a plurality of permeable layers (12) at the bottom of the storage bag (5) through a compounding technology, and attaching an isolation plastic sheet (4) on the outer wall of the permeable layer (12) at the lowest layer at the same time, so that the isolation plastic sheet (4) and the flexible assembly strip (3) are in tearable connection.
10. The method for preparing a collagen repair patch according to claim 9, wherein: in step three, still include at the top embedding design press part of PET structural layer (1), assemble isolation clamp plate (7) simultaneously below press part, make isolation clamp plate (7) can exert pressure to storage bag (5) inside, can ensure the ventilative of restoration department through the assembly space after storage bag (5) reset simultaneously.
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| CN202311402258.XA CN117137726B (en) | 2023-10-27 | 2023-10-27 | Collagen repair patch and preparation method thereof |
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| CN117137726B CN117137726B (en) | 2023-12-22 |
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| CN117137726B (en) | 2023-12-22 |
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