CN117098852A - 用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法 - Google Patents

用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法 Download PDF

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Publication number
CN117098852A
CN117098852A CN202180094850.0A CN202180094850A CN117098852A CN 117098852 A CN117098852 A CN 117098852A CN 202180094850 A CN202180094850 A CN 202180094850A CN 117098852 A CN117098852 A CN 117098852A
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CN
China
Prior art keywords
sensor
analyte
certain embodiments
asparagine
active region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202180094850.0A
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English (en)
Chinese (zh)
Inventor
刘增何
B·S·克鲁兹
Y·R·奥贾哈
B·J·弗尔德曼
T·P·利瑞
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Abbott Diabetes Care Inc
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Abbott Diabetes Care Inc
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Application filed by Abbott Diabetes Care Inc filed Critical Abbott Diabetes Care Inc
Publication of CN117098852A publication Critical patent/CN117098852A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
CN202180094850.0A 2020-12-30 2021-12-23 用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法 Pending CN117098852A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063132200P 2020-12-30 2020-12-30
US63/132,200 2020-12-30
PCT/US2021/065141 WO2022146888A1 (en) 2020-12-30 2021-12-23 Analyte sensors for detecting asparagine and aspartate and methods of use thereof

Publications (1)

Publication Number Publication Date
CN117098852A true CN117098852A (zh) 2023-11-21

Family

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CN202180094850.0A Pending CN117098852A (zh) 2020-12-30 2021-12-23 用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法

Country Status (5)

Country Link
US (2) US12345671B2 (cg-RX-API-DMAC7.html)
EP (1) EP4271825A1 (cg-RX-API-DMAC7.html)
JP (2) JP7670834B2 (cg-RX-API-DMAC7.html)
CN (1) CN117098852A (cg-RX-API-DMAC7.html)
WO (1) WO2022146888A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024211188A1 (en) * 2023-01-25 2025-07-17 Abbott Diabetes Care Inc. Temperature-insensitive membranes for analyte sensors
WO2024197225A1 (en) * 2023-03-22 2024-09-26 President And Fellows Of Harvard College Redox active antifouling coatings

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US20200237276A1 (en) * 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte sensors employing multiple enzymes and methods associated therewith
US20200237275A1 (en) * 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones

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US8444834B2 (en) 1999-11-15 2013-05-21 Abbott Diabetes Care Inc. Redox polymers for use in analyte monitoring
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CN103687535B (zh) * 2011-06-17 2017-03-22 雅培糖尿病护理股份有限公司 实现分析物传感器与其它装置之间的连接的连接器
DK3831283T3 (da) 2011-12-11 2023-05-30 Abbott Diabetes Care Inc Analytsensorindretninger, forbindelser og fremgangsmåder
WO2014099907A1 (en) 2012-12-18 2014-06-26 Abbott Diabetes Care Inc. Dermal layer analyte sensing devices and methods
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EP3570735A4 (en) 2017-01-23 2020-10-21 Abbott Diabetes Care Inc. SYSTEMS, DEVICES AND METHODS FOR INSERTING ANALYTE SENSOR
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US20200237276A1 (en) * 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte sensors employing multiple enzymes and methods associated therewith
US20200237275A1 (en) * 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones

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Publication number Publication date
US20250347647A1 (en) 2025-11-13
EP4271825A1 (en) 2023-11-08
WO2022146888A1 (en) 2022-07-07
US20220205944A1 (en) 2022-06-30
WO2022146888A9 (en) 2023-08-03
JP2025105651A (ja) 2025-07-10
JP7670834B2 (ja) 2025-04-30
US12345671B2 (en) 2025-07-01
JP2024501863A (ja) 2024-01-16

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