CN117084825A

CN117084825A - Eustachian tube medicine-carrying support and conveying device

Info

Publication number: CN117084825A
Application number: CN202210532636.5A
Authority: CN
Inventors: 张立争; 常兆华; 陈志远; 张劼; 罗七一
Original assignee: Shanghai Microport Medical Technology Co ltd
Current assignee: Shanghai Microport Medical Technology Co ltd
Priority date: 2022-05-13
Filing date: 2022-05-13
Publication date: 2023-11-21

Abstract

The application relates to a eustachian tube medicine carrying support and a conveying device, wherein the eustachian tube medicine carrying support comprises an expandable support body and an opening adjusting part connected with the support body, the support body is tubular with a channel inside, openings are formed in the front end and the tail end of the support body, the opening adjusting part is arranged close to the opening of the tail end, and when the support body is in an expansion state, the opening adjusting part enables the channel to be partially closed. The support body and the opening adjusting piece are compressed into a pressing state and are conveyed into the eustachian tube, the support body gradually expands in the eustachian tube until the outer surface of the support body is attached to the inner wall of the eustachian tube, and medicines can be carried on the support body to treat the eustachian tube; the opening position of the support body close to the tail end of the support body is connected with the opening adjusting piece, so that the channel of the support body is partially shielded, the eustachian tube is prevented from being in a completely smooth state all the time, and complications of patients caused by the long-time opening state of the eustachian tube are reduced.

Description

Eustachian tube medicine-carrying support and conveying device

Technical Field

The application relates to the technical field of medical appliances, in particular to a eustachian tube medicine carrying bracket and a conveying device.

Background

The eustachian tube connects the middle ear and the nasopharynx, the upper laryngeal region directly above the palate behind the nose, typically serves as a pressure equalizing valve for the air filled middle ear. When eustachian tube is functioning properly, it will open a fraction of a second in response to swallowing or yawning periodically (about once every three minutes), allowing air to enter the middle ear to replace air that has been absorbed by the middle ear lining (mucosa) or to balance pressure changes that occur at altitude changes. Auditory canal obstructive lesions are a clinically common problem, and any lesion that prevents periodic opening and closing of the auditory canal can lead to hearing impairment or other ear symptoms. Eustachian tube obstruction causes negative middle ear pressure with retraction (inhalation) of the eardrum. In adults, there is often some ear discomfort, fullness or pressure, and mild hearing impairment and head noise (tinnitus) can result. If the occlusion time is prolonged, fluid may be sucked from the middle ear mucosa, creating a condition known as serous otitis media (middle ear fluid). This can occur frequently in children with respiratory tract infections and lead to hearing impairment associated with the condition.

The conventional treatment method for the eustachian tube obstructive lesion is to utilize a balloon dilation catheter to convey the balloon to a lesion site through a pushing device so as to dilate the balloon to prop open the eustachian tube, and then take out the balloon. This approach can easily lead to tearing and scarring of the eustachian tube tissue, and symptoms such as bass tinnitus, ear distress, ear distention, ear pain, and autohearing are often present in patients with clinical manifestations.

Disclosure of Invention

Based on the above, it is necessary to provide a eustachian tube drug-carrying stent and a delivery device for solving the problems that the eustachian tube tissue is easily torn and discomfort such as bass tinnitus can occur to a patient in the traditional eustachian tube obstructive disease treatment mode.

The utility model provides a eustachian tube medicine-carrying support, includes expandable support body and with the aperture regulating part that support body is connected, the support body is the tubular that has the passageway inside, the front end and the tail end of support body all are equipped with the opening, the aperture regulating part is close to the opening setting of tail end, works as the support body is in the expansion state, the aperture regulating part makes the passageway part is sealed.

When the eustachian tube drug-carrying support is used, the support body and the opening adjusting piece are compressed into a pressing state and are conveyed into the eustachian tube, the support body gradually expands in the eustachian tube until the outer surface of the support body is attached to the inner wall of the eustachian tube, and drugs can be carried on the support body to treat the eustachian tube; because the eustachian tube is in the closed state under normal conditions, the eustachian tube can be opened only under the conditions of yawning, swallowing and the like, when the support body is implanted into the eustachian tube and is in an expansion state, the eustachian tube can be in an open state, and the opening position of the support body close to the tail end of the support body is connected with the opening regulating part, so that the channel of the support body is partially shielded, the eustachian tube is prevented from being in a completely unblocked state all the time, and the occurrence of complications such as bass tinnitus, eared, earache, overhung and the like of a patient caused by the long-time opening state of the eustachian tube is reduced.

In one embodiment, the opening adjusting member includes a plurality of barbs disposed along a circumferential direction of the channel, one end of each barb is rotatably connected to the tail end of the support body, and when the support body is in an expanded state, all the other ends of the barbs gather together to form an opening shape so as to cover a part of the channel, and a gap is left between adjacent barbs.

In one embodiment, the barbs are sheet-like, and when the stent body is in an expanded state, the included angle between the barbs and the axial direction of the stent body is 60 ° -110 °.

In one embodiment, the barbs are fan-shaped or triangular, and the included angle of one end of the barbs away from the bracket body is 15 degrees to 30 degrees.

In one embodiment, the barb is received in a channel of the stent body;

and/or one end of all the barbs, which is far away from the bracket body, is connected at the axle center of the bracket body.

In one embodiment, the opening adjusting member includes a plurality of expansion bodies disposed along a circumferential direction of the channel, the expansion bodies being disposed on an inner wall of the stent body, and when the stent body is in an expanded state, the expansion bodies are spread to block a portion of the channel.

In one embodiment, the opening degree adjusting member includes a wire having elasticity and located in the passage, and the wire is spread to cover a portion of the passage when the stent body is in the expanded state.

In one embodiment, the front end of the bracket body is cylindrical, and the tail end of the bracket body is in a truncated cone shape;

and/or the stent body comprises a plurality of struts, and a plurality of struts are woven to form a plurality of diamond-shaped grids.

In one embodiment, the stent body and the opening adjusting member are both made of degradable materials, and a drug-carrying coating is arranged on the outer surface of the stent body.

The utility model provides a conveyor, includes push rod and conveyer, the conveyer has the conveying passageway that runs through its front end and tail end, the conveying passageway is used for loading the eustachian tube medicine-carrying support, the push rod is arranged in the conveying passageway is used for promoting the tail end of eustachian tube medicine-carrying support.

In one embodiment, the conveying device further comprises a conveying conduit connected to the tail end of the conveyor, and the pushing rod is located in the conveying conduit;

and/or, the conveying device further comprises a pressing and holding device and a pushing device, wherein the pressing and holding device is provided with a pressing and holding channel penetrating through the front end and the tail end of the pressing and holding device, the pressing and holding channel is used for being filled with the eustachian tube medicine carrying support, and the pushing device is arranged in the pressing and holding channel and used for pushing the front end of the eustachian tube medicine carrying support so that the eustachian tube medicine carrying support enters the conveying channel.

When the eustachian tube drug-carrying support is used, one end of the eustachian tube drug-carrying support is compressed and placed into the conveyor, the eustachian tube drug-carrying support is gradually placed into the eustachian tube drug-carrying support, so that the eustachian tube drug-carrying support is ensured to completely enter the conveyor, at the moment, the eustachian tube drug-carrying support is converted from an expansion form to a pressing form, the eustachian tube drug-carrying support is conveyed to a throat through the conveyor by a nasal cavity, the pushing rod is pushed to enter the eustachian tube, the support body is gradually expanded in the eustachian tube until the outer surface of the support body is attached to the inner wall of the eustachian tube, and medicines can be carried on the support body to treat the eustachian tube; because the eustachian tube is in the closed state under normal conditions, the eustachian tube can be opened only under the conditions of yawning, swallowing and the like, when the support body is implanted into the eustachian tube and is in an expansion state, the eustachian tube can be in an open state, and the opening position of the support body close to the tail end of the support body is connected with the opening regulating part, so that the channel of the support body is partially shielded, the eustachian tube is prevented from being in a completely unblocked state all the time, and the occurrence of complications such as bass tinnitus, eared, earache, overhung and the like of a patient caused by the long-time opening state of the eustachian tube is reduced.

Drawings

Fig. 1 is a schematic perspective view of a eustachian tube drug-loading stent according to an embodiment of the present application;

FIGS. 2a-2d are schematic views of a delivery device according to an embodiment of the present application, showing a process of mounting the eustachian tube drug-carrying stent shown in FIG. 1 to the eustachian tube;

FIG. 3 is a schematic view of an opening adjuster of a eustachian tube drug-loaded stent according to an embodiment of the present application;

FIG. 4 is a schematic view of an opening adjuster of a eustachian tube drug-loaded stent according to an embodiment of the present application;

FIG. 5 is a schematic view of an opening adjuster of a eustachian tube drug-loaded stent according to an embodiment of the present application;

FIG. 6 is a schematic cross-sectional view of a eustachian tube drug-loaded stent according to another embodiment of the present application;

fig. 7 is a schematic view of a eustachian tube drug-loaded stent according to yet another embodiment of the present application.

Reference numerals illustrate:

10. a eustachian tube drug-carrying bracket; 110. a bracket body; 101. a drug-loaded coating; 112. a channel; 114. a front end; 116. tail end; 118. a support post; 119. a diamond grid; 120. an opening degree adjusting member; 122. a barb; 124. an expansion body; 126. a silk thread;

30. a push rod; 40. a conveyor; 410. a conveying channel; 50. a pusher; 60. a press grip; 610. a press-holding channel; 70. a delivery catheter;

80. eustachian tube.

Detailed Description

In order that the above objects, features and advantages of the application will be readily understood, a more particular description of the application will be rendered by reference to the appended drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. The present application may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the application, whereby the application is not limited to the specific embodiments disclosed below.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.

In the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present application, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.

Referring to fig. 1, an embodiment of the present application provides a eustachian tube drug-loading stent 10, which includes an expandable stent body 110 and an opening adjusting member 120 connected to the stent body 110, wherein the stent body 110 is tubular with a channel 112 therein, the front end 114 and the tail end 116 of the stent body 110 are both provided with openings, the opening adjusting member 120 is disposed near the opening of the tail end 116, and when the stent body 110 is in the expanded state, the opening adjusting member 120 partially closes the channel 112.

The front end 114 and the tail end 116 are referred to the moving direction of the eustachian tube drug-carrying stent 10 when the eustachian tube 80 is placed outside the body, wherein the front end 114 enters the eustachian tube 80 first and the tail end 116 enters the eustachian tube 80 later.

The eustachian tube drug-carrying stent 10 is an elastic structural member, can be self-expanded into an expanded state by self material property in a natural state, and can be compressed into a compressed state under the action of external force.

When the eustachian tube drug-loading stent 10 is used, the stent body 110 and the opening adjusting piece 120 are compressed into a pressing state and conveyed into the eustachian tube 80, the stent body 110 gradually expands in the eustachian tube 80 until the outer surface of the stent body 110 is attached to the inner wall of the eustachian tube 80, and drugs can be loaded on the stent body 110 to treat the eustachian tube 80; since the eustachian tube 80 is normally in a closed state and can be opened only under the conditions of yawning, swallowing and the like, when the support body 110 is implanted into the eustachian tube 80 and is in an expanded state, the eustachian tube 80 is in an open state, and the opening adjusting piece 120 is connected to the opening position of the support body 110 close to the tail end 116 of the support body, the channel 112 of the support body 110 is partially shielded and partially in conduction, so that the eustachian tube 80 is prevented from being in a completely smooth state all the time, and the occurrence of complications such as bass tinnitus, earache, eardistention, earache and overhigh self-hearing of a patient caused by long-time opening of the eustachian tube 80 is reduced.

Referring to fig. 1, in one embodiment, the stent body 110 is woven and includes a plurality of struts 118, the plurality of struts 118 being woven to form a plurality of diamond-shaped cells 119. The stent body 110 is formed from a plurality of struts 118 that are tightly joined one to another a plurality of times to form a tubular structure having a plurality of diamond-shaped cells 119 that are resiliently compressible and self-expandable. In other embodiments, the stent body 110 may also be fabricated in other configurations such as a mesh having a circular, triangular, or rectangular shape to meet the performance requirements of its compressibility and expansibility.

Referring to fig. 1 and 2d, further, in one embodiment, the front end 114 of the bracket body 110 is cylindrical. The tail end 116 of the bracket body 110 has a truncated cone shape, i.e., the diameter of the tail end 116 is slightly larger than the diameter of the front end 114. The shape of the front end 114 and the rear end 116 of the bracket body 110 are matched with the shape of the eustachian tube 80, and can be tightly attached to the inner wall of the eustachian tube 80 after being inflated. The opening adjusting member 120 at the tail end 116 of the stand body 110 is also pressed by the external pressure so as to be conveniently delivered to the eustachian tube 80.

In one embodiment, the outer surface of the stent body 110 is provided with a drug-loaded coating 101. Because the stent body 110 expands in the eustachian tube 80, the outer surface of the stent body 110 is attached to the inner wall of the eustachian tube 80, the drug-carrying coating 101 is arranged on the outer surface of the stent body 110, the drug (such as sterol, anti-inflammatory drug, antibiotic and the like) carried by the drug-carrying coating 101 on the outer surface is attached to the inner wall of the eustachian tube 80 and stretches the eustachian tube 80, the drug is automatically released in the body to treat the blocking condition of the eustachian tube 80, and the drug release period can be set to 1 to 3 weeks so as to achieve continuous drug administration effect, realize accurate and continuous drug administration and treat the blocking condition of the eustachian tube 80.

In one embodiment, the bracket body 110 and the opening adjusting member 120 are made of degradable materials, so as to avoid the pain of the patient caused by the need of taking out the materials again through the operation. The eustachian tube drug-loaded stent 10 is fabricated from a degradable material including, but not limited to, the following degradable polymers: polylactic acid (PLA), L-polylactic acid (PLLA or LPLA), polyglycolic acid/polylactic acid copolymer (polyglycolic acid/polylactic acid, PGLA), chitosan, PVA, and copolymers or blends of the above, and homologs thereof. And (3) performing engraving or hollowed-out processing by manpower or a machine, or directly forming, and finally forming through a heat setting process. The degradation time is selected to be 4-6 weeks by the material proportion, and the eustachian tube 80 is automatically degraded into water and carbon dioxide after healing.

Referring to fig. 1, in one embodiment, the opening adjusting member 120 includes a plurality of barbs 122 disposed along the circumferential direction of the channel 112, one end of each barb 122 is rotatably connected to the tail end 116 of the bracket body 110, and when the bracket body 110 is in the expanded state, one end of each barb 122 rotates to gather the other ends thereof, so that the opening adjusting member is in a stretched shape to cover a portion of the channel 112, and a gap is left between adjacent barbs 122. The plurality of barbs 122 obstruct a portion of the channels 112 of the stent body 110, and the gaps between the barbs 122 allow a portion of the channels 112 to remain open, avoiding the channels 112 from being completely open at all times. Referring to fig. 3, 4 and 5, the number and size of barbs 122 can be adaptively adjusted according to whether the patient is uncomfortable or not in response to the patient's own reaction, so as to meet the needs of different patients and relieve the pain of the patients. Barbs 122 may be integrally woven or machined into the stent.

In one embodiment, barbs 122 are sheet-like to provide some degree of shielding of passage 112 after compression and expansion of barbs 122. Alternatively, the barbs 122 may be angled at an angle a of 60 ° -110 ° with respect to the axial direction of the stent body 110 when the stent body 110 is in the expanded state. Fig. 2d is a schematic view of the eustachian tube drug-loaded stent 10 in an expanded state mounted within the eustachian tube 80. In the expansion process of the bracket body 110, one end of the barb 122 away from the axis of the bracket body 110 rotates relative to the bracket body 110 at the same time, and the included angle a between the barb 122 and the axis direction of the bracket body 110 gradually increases until the expansion of the bracket body 110 is completed, and the included angle a between the barb 122 and the axis direction of the bracket body 110 is kept stable, at this time, the included angle a is 60 ° -110 °, preferably 90 °.

Optionally, in one embodiment, barbs 122 are received within channels 112 of bracket body 110. Referring to fig. 2b and 2d, fig. 2b shows a schematic view of the eustachian tube drug-loading stent 10 in a compressed state, and fig. 2d shows the eustachian tube 80 in an expanded state. The barbs 122 are received in the channels 112 in both the compressed and expanded states. In other embodiments, barbs 122 may be provided protruding from channel 112.

Referring to fig. 3, 4, 5, alternatively, in one embodiment, barbs 122 are scalloped or triangular in shape. The barbs 122 shown in fig. 3 and 4 are in the form of a sheet-like fan having one end remote from the bracket body 110 at the center of the fan. Fig. 5 shows barbs 122 having a sheet-like triangle shape with one end distal to stent body 110 at the apex of the triangle. Alternatively, in one embodiment, the included angle b of the end of barb 122 remote from bracket body 110 is 15 ° -30 °. The adjustment of the included angle b allows for the adjustment of the size of barb 122 and thus the passage area of channel 112.

Optionally, in one embodiment, an end of each barb 122 distal to the stent body 110 is connected at the axial center of the stent body 110. That is, the end of each barb 122 remote from the stent body 110 is integrally connected to form an umbrella-like skeleton structure, which is folded in response to the compression of the stent body 110 and unfolded in response to the expansion of the stent body 110. In other embodiments, the end of each barb 122 distal to the stent body 110 is a free end that is compressed as the stent body 110 compresses and rotationally expands as the stent body 110 expands.

Referring to fig. 6, in another embodiment, the opening degree adjusting member 120 includes a plurality of expansion bodies 124 disposed along the circumferential direction of the channel 112, the expansion bodies 124 being disposed on the inner wall of the stent body 110, and when the stent body 110 is in the expanded state, the expansion bodies 124 are spread to block a portion of the channel 112. The expansion body 124 is compressed and contracted in the channel 112 when the stent body 110 is in a compressed state, and when the stent body 110 is in an expanded state, the expansion body is expanded in the channel 112 so as to partially block the passage of the channel 112, thereby avoiding the eustachian tube 80 from being in a completely opened state for a long time and reducing the pain of a patient. The expansion body 124 may be woven or otherwise machined into the channel 112 or integrally woven or machined with the stent body 110. The expansion body 124 can also be made of degradable materials, and can be automatically degraded after treatment. The size and number of the expansion bodies 124 can be adjusted to adjust the passage area of the channel 112 according to the patient's fitness. The expansion body 124 may be provided in a spherical structure having a mesh.

Referring to fig. 7, in still another embodiment, the opening degree adjuster 120 includes a wire 126 having elasticity, the wire 126 is wound around the stent body 110 along the axial direction of the stent body 110, and when the stent body 110 is in the expanded state, the wire 126 is spread to block a portion of the channel 112. An elastic thread 126 is used as the opening adjusting member 120, and at least a portion of the thread 126 is disposed at the opening of the tail end 116 of the bracket body 110. The silk threads 126 are also extruded in the process of compressing the stent body 110 so as to ensure that the entire eustachian tube drug-loaded stent 10 is in a contracted state, and the silk threads 126 are then spread in the process of expanding the stent body 110 so as to partially block the passage of the channel 112, thereby avoiding the eustachian tube 80 from being in a completely opened state for a long time and reducing the pain of patients. The wires 126 may be woven or otherwise machined into the channels 112 or integrally woven or machined with the stent body 110. The wire 126 may also be made of a degradable material that self-degrades after the treatment is completed. The density of the wires 126 may be adjusted to adjust the passage area of the channel 112 according to the patient's fitness.

Because of the small size of the eustachian tube 80, the eustachian tube drug-loaded stent 10 is difficult to implant directly into the eustachian tube 80, and therefore a delivery device is required to deliver the eustachian tube drug-loaded stent 10 to the eustachian tube 80. Thus, referring to FIGS. 2a-2d, a further embodiment of the present application provides a delivery device comprising a push rod 30 and a conveyor 40. The conveyor 40 has a conveyor channel 410 extending through its leading and trailing ends 114, 116, the conveyor channel 410 being adapted to carry the eustachian tube drug-delivery stent 10 of any of the embodiments described above, and the push rod 30 being disposed within the conveyor channel 410 for pushing the trailing end 116 of the eustachian tube drug-delivery stent 10.

When the eustachian tube medicine-carrying support 10 is used, one end of the eustachian tube medicine-carrying support 10 is compressed and placed into the conveyor 40, the eustachian tube medicine-carrying support 10 is gradually placed into the eustachian tube medicine-carrying support 10, so that the eustachian tube medicine-carrying support 10 is ensured to completely enter the conveyor 40, at the moment, the eustachian tube medicine-carrying support 10 is converted from an expansion form to a holding form, the eustachian tube medicine-carrying support 10 is conveyed to a throat through the conveyor 40 by a nasal cavity, the push rod 30 is pushed to enter the eustachian tube 80, the support body 110 gradually expands in the eustachian tube 80 until the outer surface of the support body 110 is attached to the inner wall of the eustachian tube 80, and medicines are carried on the support body 110 to treat the eustachian tube 80; since the eustachian tube 80 is in a closed state under normal conditions, the eustachian tube 80 can be opened only under the conditions of yawning, swallowing and the like, when the support body 110 is implanted into the eustachian tube 80 and is in an expanded state, the eustachian tube 80 can be in an open state, and the opening position of the support body 110 close to the tail end 116 of the support body is connected with the opening adjusting piece 120, so that the channel 112 of the support body 110 is partially shielded, the eustachian tube 80 is prevented from being in a completely unblocked state all the time, and the complications of bass tinnitus, ear distress, ear distention, ear pain, overhigh hearing and the like of a patient caused by long-time opening of the eustachian tube 80 in the traditional treatment mode are reduced.

Further, in one embodiment, the delivery device further comprises a delivery catheter 70, the delivery catheter 70 being coupled to the trailing end 116 of the delivery device 40, the push rod 30 being positioned within the delivery catheter 70. The drug-carrying support 10 of the eustachian tube is gradually conveyed to the eustachian tube 80 from the front end 114 to the tail end 116 of the drug-carrying support 10 of the eustachian tube by pushing the push rod 30 after the delivery device enters from nostrils to the throat through guiding the delivery catheter 70.

Further, the delivery device further comprises a press grip 60 and a pusher 50, wherein the press grip 60 is provided with a press grip channel 610 penetrating through the front end 114 and the tail end 116 of the press grip channel 610, the press grip channel 610 is used for accommodating the eustachian tube drug-carrying stent 10, and the pusher 50 is arranged in the press grip channel 610 and is used for pushing the front end 114 of the eustachian tube drug-carrying stent 10 so as to enable the eustachian tube drug-carrying stent 10 to enter the delivery channel 410. Because of the large size of the eustachian tube drug-loaded stent 10 in the expanded state, it is difficult to fit the delivery channel 410, pre-compress the eustachian tube 80 into the crimped state by the crimping apparatus, and then push the eustachian tube into the delivery channel 410 by the pusher 50.

Taking the eustachian tube drug-loaded stent 10 with the opening adjusting member 120 including a plurality of barbs 122 as an example, the delivery process of the eustachian tube drug-loaded stent 10 will be described in detail:

step one, referring to fig. 2a, in the surgical treatment process, the doctor needs to squeeze the eustachian tube drug-carrying stent 10 by external force because the eustachian tube drug-carrying stent 10 is in an expanded state by default, put it into the press-grip device 60, and push it into the conveyor 40 by the pusher 50; referring to fig. 2b, the eustachian tube drug-loaded stent 10 is now crimped to the delivery channel 410 of the delivery device 40. At this point, barbs 122 are compressed and received in tail ends 116 of channels 112.

Step two, referring to fig. 2c, with the help of the endoscope, the doctor enters the conveyor 40 carrying the eustachian tube drug-carrying stent 10 from the nostril under the guidance of the conveying catheter 70, conveys the eustachian tube drug-carrying stent 10 from the conveyor 40 to the pharynx through the nasal cavity, and pushes the eustachian tube drug-carrying stent into the eustachian tube 80 by the pushing rod 30. Since the eustachian tube drug-loaded stent 10 is implanted in a compressed state, self-distraction is achieved as it is delivered to the eustachian tube 80. Referring to fig. 2d, the eustachian tube drug-loading stent 10 has been expanded at this time, and the stent body 110 is tightly attached to the inner wall of the eustachian tube 80 under the action of the mutual extrusion of the strut 118 and the inner wall of the eustachian tube 80, so that the eustachian tube 80 is continuously administered with the drug carried by the drug-loading coating 101 for treatment. At this time, all barbs 122 are in an expanded state so that stent body 110 is in a non-complete access state, avoiding the eustachian tube 80 from being in an expanded state all the time when eustachian tube drug-loaded stent 10 is implanted in a human body.

Similarly, the eustachian tube drug-carrying stent 10 shown in fig. 6 and 7 can be mounted on the eustachian tube 80 in the manner described above, so that the eustachian tube 80 can be treated.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.

Claims

1. The utility model provides a eustachian tube medicine-carrying support, its characterized in that, including expandable support body and with the aperture regulating part that support body is connected, the support body is the tubular that has the passageway inside, the front end and the tail end of support body all are equipped with the opening, aperture regulating part is close to the opening setting of tail end, works as the support body is in the expansion state, aperture regulating part makes the passageway part is sealed.

2. The eustachian tube drug-loading support according to claim 1, wherein the opening adjusting member comprises a plurality of barbs arranged along the circumferential direction of the channel, one end of each barb is rotatably connected with the tail end of the support body, when the support body is in an expanded state, the other ends of all the barbs gather together to enable the opening adjusting member to be in a stretched shape so as to cover part of the channel, and a gap is reserved between every two adjacent barbs.

3. The eustachian tube drug-loaded stent of claim 2, wherein the barbs are sheet-like and have an included angle of 60 ° to 110 ° with respect to the axial direction of the stent body when the stent body is in the expanded state.

4. A eustachian tube drug-loaded stent according to claim 3, wherein the barbs are in the shape of a fan or triangle, and the included angle of the end of the barb away from the stent body is 15 ° -30 °.

5. The eustachian tube drug-loaded stent of claim 4, wherein the barbs are received in a channel of the stent body;

6. The eustachian tube drug-loaded stent according to claim 1, wherein the opening degree adjusting member comprises a plurality of expansion bodies arranged in the circumferential direction of the passage, the expansion bodies being arranged on the inner wall of the stent body, the expansion bodies being spread to shield a portion of the passage when the stent body is in an expanded state.

7. The eustachian tube drug-loaded stent of claim 1, wherein the opening adjustment member comprises a wire positioned within the channel and having elasticity, the wire expanding to occlude a portion of the channel when the stent body is in an expanded state.

8. The eustachian tube drug-loaded stent of any one of claims 1-7, wherein the front end of the stent body is cylindrical and the tail end of the stent body is frustoconical;

9. The eustachian tube drug-loaded stent according to any one of claims 1-7, wherein the stent body and the opening adjusting member are both degradable materials, and the outer surface of the stent body is provided with a drug-loaded coating.

10. A delivery device comprising a push rod and a conveyor, wherein the conveyor has a delivery channel extending through a front end and a rear end thereof, the delivery channel is used for loading the eustachian tube drug-carrying stent of any one of claims 1-9, and the push rod is arranged in the delivery channel and is used for pushing the rear end of the eustachian tube drug-carrying stent.

11. The delivery device of claim 10, further comprising a delivery conduit connected to a trailing end of the conveyor, the push rod being located within the delivery conduit;

and/or, the conveying device further comprises a pressing and holding device and a pushing device, the pressing and holding device is provided with a pressing and holding channel penetrating through the front end and the tail end of the pressing and holding device, the pressing and holding channel is used for being filled with the eustachian tube medicine carrying support according to any one of claims 1-9, and the pushing device is arranged in the pressing and holding channel and used for pushing the front end of the eustachian tube medicine carrying support so as to enable the eustachian tube medicine carrying support to enter the conveying channel.