CN117064832A - 一种护理固齿专用牙膏制备方法 - Google Patents
一种护理固齿专用牙膏制备方法 Download PDFInfo
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- CN117064832A CN117064832A CN202311285466.6A CN202311285466A CN117064832A CN 117064832 A CN117064832 A CN 117064832A CN 202311285466 A CN202311285466 A CN 202311285466A CN 117064832 A CN117064832 A CN 117064832A
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Classifications
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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Abstract
本发明提供一种护理固齿专用牙膏制备方法，包括有中药组分、防腐剂组分、摩擦剂组分、起泡剂组分、成膜剂组分、多元醇和小分子水凝胶组分；中药组分包括熟附片、青盐、石菖蒲和云母石，防腐剂组分包括苯扎氯铵、苯佐卡因、薄荷醇和氯化锌，摩擦剂组分包括二水磷酸氢钙、沉淀二氧化硅或氢氧化铝；本发明利用壳聚糖和葛根素在研磨稀化后自组装成水凝胶主体，油凝胶颗粒可吸收和去除油性污渍，并可在牙齿表面形成一层保护膜，并组合使用多种具有消炎、抗菌、镇痛及改善牙齿松动功能的中药成分，对牙齿表面及口腔内伤口均有保护和辅助治疗效果。
Description
技术领域
本发明涉及口腔护理技术领域，尤其是一种护理固齿专用牙膏制备方法。
背景技术
随着社会的发展，越来越多的人开始重视口腔健康，牙膏是我们每日必备的洁牙制品的一种，一般呈凝胶状，通常会抹在牙刷上，借助牙刷的机械摩擦的作用清洁牙齿表面，对牙齿及其周边进行清洁，使口腔净化清爽，通过每日使用牙膏刷牙来使牙齿洁白美观、防止口臭，同时保持牙齿清洁和保护牙龈，以及预防其他多种常见的口腔疾病是最为经济和便捷的手段，虽然牙膏可以有效地去除牙菌斑、提供固齿或脱敏的效果并在口腔中提供清新的感觉，但牙膏的酸碱度、漂白剂以及摩擦剂会影响牙齿的坚固程度，如酸碱度过高、氧化性过强以及摩擦剂颗粒过大和浓度过高，均会造成在刷洗过程中对牙齿产生二次磨损或二次腐蚀副作用，严重时甚至会提高牙齿敏感的风险。
最常见的口腔疾病包括：牙周病、口腔溃疡，其中牙周病主要指牙周炎和牙龈炎，是常见的感染性口腔疾病。牙周病的发病率尤其显著，成人牙周病患者占97％，是35岁以上人群失去牙齿的主要原因，大概10位老人中因此病就有一位全口无牙。因此，口腔疾病以发病率高、患病人群广、大众化为特点，成为世界上最为多发的一种疾病。
牙龈指紧贴于牙颈周围及邻近的牙槽骨上淡红色的结构，由复层扁平上皮及固有层组成。是口腔粘膜的一部分，血管丰富，呈淡红色，坚韧而有弹性，因缺乏粘膜下层，直接与骨膜紧密相连。牙龈相当于牙齿的肌肉，牙龈强壮程度决定了牙齿是否有力和牢固，其像一道屏障紧紧包裹牙齿根部，防止牙石、酸性物质的侵蚀，因此牙龈受损势必影响牙齿健康。
考虑牙膏组分在牙齿表面的粘附性以及对牙齿缺陷的填充保护作用，现有的牙膏组分还需进一步改进，在护理固齿的同时，最大程度的降低对牙齿的损伤风险。
发明内容
有鉴于此，本发明提供了一种护理固齿专用牙膏制备方法。
为实现上述目的，本发明提供如下技术方案，一种护理固齿专用牙膏制备方法，包括有中药组分、防腐剂组分、摩擦剂组分、起泡剂组分、成膜剂组分、多元醇和小分子水凝胶组分；所述中药组分包括熟附片、青盐、石菖蒲和云母石，其中熟附片、青盐、石菖蒲和云母石的重量比例为1：1：0.5：5；所述防腐剂组分包括苯扎氯铵、苯佐卡因、薄荷醇和氯化锌，所述摩擦剂组分包括二水磷酸氢钙、沉淀二氧化硅或氢氧化铝；所述起泡剂组分包括越贵硫酸酯钠或月桂酰肌氨酸钠；所述小分子水凝胶包括由壳聚糖和葛根素在乙酸水溶液中形成的小分子水凝胶；所述成膜剂组分包括丙烯酸树脂，所述丙烯酸树脂通过丙烯酸、甲基丙烯酸和丙烯酸酯嘞单位共聚所得，所述丙烯酸酯类单位包括甲基丙烯酸甲酯、甲基丙烯酸乙酯、甲基丙烯酸正丁酯和强甲基丙烯酸乙酯中的至少一种；所述多元醇包括山梨糖醇或甘油中的至少一种。
优选地，包括以下步骤；
S1：低速搅拌下，在75±5℃中投入成膜剂组分和乙基纤维素，形成淤浆，转为中速搅拌，剪切降低粘度，并加入乙基纤维素或水，调节至中速搅拌下的体系粘度为5-10cP，再投入多元醇、苯扎氯铵、苯佐卡因、薄荷醇和起泡剂组分，经过乳化处理，得到油凝胶乳化液，控制固含量为3-4wt％；油凝胶乳化液降低至室温出现分层，由于多元醇密度大于水，下层为呈现非牛顿流体的油凝胶A，上层为水溶液B；
S2：将摩擦剂组分经过粉碎机初步粉碎至粒径200μm以下，投入到研磨粉碎机中，采用80#～120#的研磨剂，研磨至粒径小于30μm；取出研磨剂，再加入S1的油凝胶A，继续研磨混合，形成表面粘附有摩擦剂的油凝胶颗粒C，取出备用；取S1的水溶液B一部分，投入乙酸，配置0.5wt％的乙酸水溶液D，并分为两个批次使用；取S1的水溶液B另一部分作为溶剂使用；采用溶剂对研磨粉碎机进行清洗2-3次，合并得到清洗液E；
S3：将小分子水凝胶组分、熟附片、青盐、石菖蒲和云母石和氯化锌依次投入到研磨粉碎机中，在研磨剪切的混合作用后，加入部分的乙酸水溶液D溶剂化并研磨直至乙酸挥发，加入溶剂进一步分散，并加入另一部分的乙酸水溶液D，将研磨粉碎机中溶液体系投入到高速剪切均质机，并用溶剂对研磨粉碎机清洗1-2次，得到的清洗液F与清洗液E合并投入到高速剪切均质机，15000r/min搅拌2～5min，静置5min，得到水凝胶前驱体G；
S4：将油凝胶颗粒C及辅料加入到新制的水凝胶前驱体G中，低速搅拌5min，并调节体系pH呈微酸性，测试pH为5.7～6.4，测试并调节体系粘度为10～15cP，得到牙膏前体H；
S5：在低速搅拌下，将牙膏前体H灌装至产品容器中，产品容器包括牙膏皮或牙膏瓶，室温下静置6～8小时后，变成具有弹性且保水的、膏状的成品牙膏H。
优选的，低速搅拌的搅拌速度为30-50r/min，中速搅拌的搅拌速度为800-1500r/min，高速搅拌的转速为18000r/min，通过告诉剪切降低体系粘度，在通过乳化处理。
青盐是清热凉血药，为卤化物类石盐族湖盐结晶体，主含氯化钠(NaC l)，作用于治尿血，吐血，齿舌出血，目赤痛，风眼烂弦，牙痛等症状；石菖蒲一般指金钱蒲，植株丛生状，芳香；叶基对折，两侧膜质叶鞘棕色，脱落；肉穗花序黄绿色，圆柱形；果黄绿色；花期5-6月；果期7-8月，金钱蒲根茎可入药，主治痰涎壅闭、神识不清、慢性气管炎；痢疾、肠炎等。《神农本草经》记载金钱蒲“主风寒湿痹，咳逆上气，开心孔，补五脏，通九窍，明耳目，出音声”；云母石为为不规则的片状，数层至数十层叠合在一起，大小不一，无色透明或白色，具珍珠样或玻璃样光泽。质韧，可层层剥离成薄片，薄片光滑透明，有弹性。气微，无味。以片大、透明、洁净、无色、易剥离者为佳，可用于补肾，收敛止血。用于劳伤虚损，眩晕，惊悸，癫痫，寒症久疟，疮痈肿痛，刀伤出血。这几种药材对于止血方面都具有很好的功效，对牙龈以及牙齿的护理有很好的效果。
本发明利用熟附片、青盐、石菖蒲和云母石几味中药的止血以及对人体的滋补效果，壳聚糖和葛根素在研磨稀化后自组装成水凝胶主体，油凝胶颗粒可吸收和去除油性污渍，并可在牙齿表面形成一层保护膜，并组合使用多种具有消炎、抗菌、镇痛及改善牙齿松动功能的中药成分，对牙齿表面及口腔内伤口均有保护和辅助治疗效果
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
基于前人的工作，CS和PUE可以方便地组装成由机械力触发的纳米纤维水凝胶。水凝胶的形成与纳米纤维结构的聚集密切相关。同时，非共价相互作用诱导的自组装CS@PUE(C@P)水凝胶具有剪切稀化和自愈能力，可注射到不规则伤口中。水凝胶的特殊结构和理化性质可以有效地破坏细菌电荷平衡，就像带正电的操纵器捕获带负电荷的细菌一样，可以显着提高抗菌能力。
参照现有制备方法：50g壳聚糖(CS)和50g葛根素(PUE)投入到研磨粉碎机中，在研磨剪切的混合作用后，加入0.3L的0.5wt％乙酸水溶液溶剂化并研磨直至乙酸挥发，加入到另一个9L超纯水以进一步分散，加入1L的0.5wt％乙酸水溶液，混合物变得均匀和粘稠，室温下保持混合物12小时后获得小分子水凝胶(一般简称为C@P水凝胶)。
一种护理固齿专用牙膏制备方法，包括以下步骤；
S1：低速搅拌下，在75±5℃中投入成膜剂组分和乙基纤维素，形成淤浆，转为中速搅拌，剪切降低粘度，并加入乙基纤维素或水，调节至中速搅拌下的体系粘度为5-10cP，再投入多元醇、苯扎氯铵、苯佐卡因、薄荷醇和起泡剂组分，经过乳化处理，得到油凝胶乳化液，控制固含量为3-4wt％；油凝胶乳化液降低至室温出现分层，由于多元醇密度大于水，下层为呈现非牛顿流体的油凝胶A，上层为水溶液B；
S2：将摩擦剂组分经过粉碎机初步粉碎至粒径200μm以下，投入到研磨粉碎机中，采用80#～120#的研磨剂，研磨至粒径小于30μm；取出研磨剂，再加入S1的油凝胶A，继续研磨混合，形成表面粘附有摩擦剂的油凝胶颗粒C，取出备用；取S1的水溶液B一部分，投入乙酸，配置0.5wt％的乙酸水溶液D，并分为两个批次使用；取S1的水溶液B另一部分作为溶剂使用；采用溶剂对研磨粉碎机进行清洗2-3次，合并得到清洗液E；
S3：将小分子水凝胶组分、熟附片、青盐、石菖蒲和云母石和氯化锌依次投入到研磨粉碎机中，在研磨剪切的混合作用后，加入部分的乙酸水溶液D溶剂化并研磨直至乙酸挥发，加入溶剂进一步分散，并加入另一部分的乙酸水溶液D，将研磨粉碎机中溶液体系投入到高速剪切均质机，并用溶剂对研磨粉碎机清洗1-2次，得到的清洗液F与清洗液E合并投入到高速剪切均质机，15000r/min搅拌2～5min，静置5min，得到水凝胶前驱体G；
S4：将油凝胶颗粒C及辅料加入到新制的水凝胶前驱体G中，低速搅拌5min，并调节体系pH呈微酸性，测试pH为5.7～6.4，测试并调节体系粘度为10～15cP，得到牙膏前体H；
S6：在低速搅拌下，将牙膏前体H灌装至产品容器中，产品容器包括牙膏皮或牙膏瓶，室温下静置6～8小时后，变成具有弹性且保水的、膏状的成品牙膏。
实施例2
表1，中药的成分含量表
由表1所得实验数据进行比对，刷洗30s，用水冲10s，再刷30s，再用水冲10s，检测对牙齿的清洁以及护理程度，得出各个药材之间有相互促进的作用，且比例为1:1:0.5:5的时候效果为最佳。
实施例3
一种护理固齿专用牙膏制备方法，各个组分重量百分比为：中药组分20～30％，防腐剂组分5～10％，摩擦剂组分20～30％，起泡剂组分1～3％，成膜剂组分5～10％，小分子水凝胶组分30～40％，辅料1～15％；防腐剂组分中苯扎氯铵、苯佐卡因、薄荷醇和氯化锌的重量比为1:100～200:1.5～2:1.2～1.5；成膜剂组分中丙烯酸树脂的聚合度为2000～4000，丙烯酸树脂中丙烯酸、甲基丙烯酸和丙烯酸酯类单体的摩尔比为1:1:0.8～1.2；小分子水凝胶中壳聚糖和葛根素质量比为1:1。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (3)
1.一种护理固齿专用牙膏制备方法，其特征在于，包括有中药组分、防腐剂组分、摩擦剂组分、起泡剂组分、成膜剂组分、多元醇和小分子水凝胶组分；所述中药组分包括熟附片、青盐、石菖蒲和云母石，其中熟附片、青盐、石菖蒲和云母石的重量比例为1：1：0.5：5；所述防腐剂组分包括苯扎氯铵、苯佐卡因、薄荷醇和氯化锌，所述摩擦剂组分包括二水磷酸氢钙、沉淀二氧化硅或氢氧化铝；所述起泡剂组分包括越贵硫酸酯钠或月桂酰肌氨酸钠；所述小分子水凝胶包括由壳聚糖和葛根素在乙酸水溶液中形成的小分子水凝胶；所述成膜剂组分包括丙烯酸树脂，所述丙烯酸树脂通过丙烯酸、甲基丙烯酸和丙烯酸酯嘞单位共聚所得，所述丙烯酸酯类单位包括甲基丙烯酸甲酯、甲基丙烯酸乙酯、甲基丙烯酸正丁酯和强甲基丙烯酸乙酯中的至少一种；所述多元醇包括山梨糖醇或甘油中的至少一种。
2.根据权利要求1所述的一种护理固齿专用牙膏制备方法，其特征在于，还包括有辅料和水，所述辅料包括食用香精、味觉改良剂和酸碱缓冲剂。
3.根据权利要求1所述的一种护理固齿专用牙膏制备方法，其特征在于，包括以下步骤；
S1：低速搅拌下，在75±5℃中投入成膜剂组分和乙基纤维素，形成淤浆，转为中速搅拌，剪切降低粘度，并加入乙基纤维素或水，调节至中速搅拌下的体系粘度为5-10cP，再投入多元醇、苯扎氯铵、苯佐卡因、薄荷醇和起泡剂组分，经过乳化处理，得到油凝胶乳化液，控制固含量为3-4wt％；油凝胶乳化液降低至室温出现分层，由于多元醇密度大于水，下层为呈现非牛顿流体的油凝胶A，上层为水溶液B；
S2：将摩擦剂组分经过粉碎机初步粉碎至粒径200μm以下，投入到研磨粉碎机中，采用80#～120#的研磨剂，研磨至粒径小于30μm；取出研磨剂，再加入S1的油凝胶A，继续研磨混合，形成表面粘附有摩擦剂的油凝胶颗粒C，取出备用；取S1的水溶液B一部分，投入乙酸，配置0.5wt％的乙酸水溶液D，并分为两个批次使用；取S1的水溶液B另一部分作为溶剂使用；采用溶剂对研磨粉碎机进行清洗2-3次，合并得到清洗液E；
S3：将小分子水凝胶组分、熟附片、青盐、石菖蒲和云母石和氯化锌依次投入到研磨粉碎机中，在研磨剪切的混合作用后，加入部分的乙酸水溶液D溶剂化并研磨直至乙酸挥发，加入溶剂进一步分散，并加入另一部分的乙酸水溶液D，将研磨粉碎机中溶液体系投入到高速剪切均质机，并用溶剂对研磨粉碎机清洗1-2次，得到的清洗液F与清洗液E合并投入到高速剪切均质机，15000r/min搅拌2～5min，静置5min，得到水凝胶前驱体G；
S4：将油凝胶颗粒C及辅料加入到新制的水凝胶前驱体G中，低速搅拌5min，并调节体系pH呈微酸性，测试pH为5.7～6.4，测试并调节体系粘度为10～15cP，得到牙膏前体H；
S6：在低速搅拌下，将牙膏前体H灌装至产品容器中，产品容器包括牙膏皮或牙膏瓶，室温下静置6～8小时后，变成具有弹性且保水的、膏状的成品牙膏H。
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