CN117051414A - Method for electrochemically synthesizing aryl sulfonyl fluoride compound - Google Patents

Abstract

The invention discloses a method for electrochemical synthesis of arylsulfonyl fluoride compounds, which is characterized in that the method includes the following steps: S1. Under an inert atmosphere, combine the reaction raw materials aryl triflate, DABSO and fluorine Potassium hydride is mixed in the electrolytic cell; then the reaction medium and electrolyte are added to the electrolytic cell, and then an organic solvent is added for dissolution; S2. Insert an electrode into the electrolytic cell and energize it for electrochemical reaction; S3. Reaction Afterwards, extraction, drying and purification are performed to obtain the arylsulfonyl fluoride compound. The synthesis method provided by the invention has simple synthesis steps. Compared with the traditional synthesis method of preparing arylsulfonyl fluoride compounds by breaking C-O bonds in activated phenols and their derivatives, the synthesis method provided by the invention is more efficient in terms of instrumentation and equipment. The requirements are not high, no metal catalyst is used, cost is saved, the reaction conditions are mild, the operation steps are simple, the reaction time is short, and the yield is high.

Description

A method for electrochemical synthesis of aromatic sulfonyl fluoride compounds

Technical field

The invention relates to the technical field of electrochemical synthesis, and in particular to a method for electrochemical synthesis of aromatic sulfonyl fluoride compounds.

Background technique

Sulfonyl fluoride compounds have special reactivity, stable balance, resistance to oxidation and reduction, and high thermodynamic stability against nucleophilic substitution reactions. They are high-value synthetic fragments in organic synthesis. The fluorosulfonyl group (SO ₂ F) can be found in almost all areas of modern chemistry, such as drug discovery, chemical biology, and materials science. However, the current methods for introducing fluorosulfonyl groups (SO ₂ F) into organic molecules are still very limited, severely limiting further research and applications of their reactions. Therefore, it is of great significance to explore new methods for efficiently constructing sulfonyl fluoride compounds from simple raw materials.

Phenol and its homologs are widely present in lignin, so the development of chemical reactions using phenol derivatives as starting materials has broad application prospects. However, due to the p-π bond conjugation, phenolic compounds have very active acidic hydroxyl groups and high dissociation energy C-O bonds, which makes the direct C-O bond cleavage coupling reaction of phenolic compounds difficult to achieve. Therefore, converting phenolic compounds into phenolic derivatives, such as aryl triflate compounds, not only eliminates the acidity of the phenolic hydroxyl group, but also reduces the bond energy of the C-O bond. In recent years, transition metal-catalyzed aryl trifluoromethanesulfonate activation reactions through C-O bond activation have received widespread attention. This type of reaction usually requires the addition of an equivalent amount of metal reducing agent or a combination of photocatalysis (Reference: M. Ratushnyy, N. Kvasovs, S. Sarkar, V. Gevorgyan, Visible Light-Induced Palladium-Catalyzed Generation of Aryl Radicals from Aryl Triflates. Angew. Chem. Int. Ed. 2020, 59, 10316–10320). However, in actual production, especially in pharmaceutical synthesis chemistry, the requirements for metal residues are very strict, and trace amounts of metals often require high costs in the post-processing process. Therefore, it is very necessary to develop green and efficient metal-free catalyzed sulfonyl fluorination of carbon-halogen bonds. Organic electrochemical synthesis is a green, mild, and efficient synthesis strategy. However, due to the direct electrode reduction of aryl trifluoromethanesulfonate, the S-O bond will be broken, producing trifluoromethanesulfonyl radicals and the corresponding phenoxide. , and no C-O bond cleavage will occur to generate aryl radicals. Therefore, it can be predicted that under reducing conditions, the S-O cleavage of aryl trifluoromethanesulfonate to generate phenolic compounds is the most intense competitive reaction for the C-O cleavage of aryl radicals. It can be seen that a suitable electron donor is crucial for the single electron transfer (SET) of aryl trifluoromethanesulfonate to produce aryl radicals due to C-O bond cleavage while avoiding S-O bond cleavage.

This application contemplates whether an aryl sulfonyl fluoride compound can be synthesized using aryl trifluoromethanesulfonate as a raw material at room temperature and without metal catalysis in the form of a medium.

Contents of the invention

Metal reagents and precious metal catalysts are often used in existing synthesis methods, which have the problem of high cost; photocatalytic synthesis methods are also used, which have the problems of narrow light sources and substrate ranges; in view of the problems existing in the existing synthesis methods, this paper The invention provides a new electrochemical synthesis process with low cost, simple synthesis steps and wide sources of raw materials.

The present invention is achieved through the following technical solutions:

A method for electrochemical synthesis of arylsulfonyl fluoride compounds, characterized in that the method includes the following steps:

S1. Under an inert atmosphere, mix the reaction raw materials aryl triflate, DABSO and potassium hydrogen fluoride in the electrolytic cell;

Then the reaction medium and electrolyte are added to the electrolytic tank, and then an organic solvent is added for dissolution;

S2. Insert an electrode into the electrolytic cell and energize it for electrochemical reaction;

S3. After the reaction, extraction, drying, and purification are performed to obtain an arylsulfonyl fluoride compound.

The invention provides an aryl trifluoromethanesulfonate, DABSO and potassium hydrogen fluoride (KHF ₂ ) as raw materials, 9,10-dicyananthracene as a medium, acetonitrile as a solvent, ⁿ Bu ₄ NClO ₄ as an electrolyte , a method for directly preparing aromatic sulfonyl fluoride compounds using electrochemistry in a nitrogen atmosphere.

Specifically, the present invention provides a method for electrochemically synthesizing aromatic sulfonyl fluoride compounds using phenol derivatives as raw materials.

Further, a method for electrochemical synthesis of arylsulfonyl fluoride compounds: the molar ratio between the aryl triflate, DABSO and potassium hydrogen fluoride described in step S1 is (1~3):1 :(3～5).

Preferably, the molar ratio between aryl triflate, DABSO and potassium hydrogen fluoride is 4:3:12.

Further, a method for electrochemically synthesizing an arylsulfonyl fluoride compound: the concentration of the aryl triflate described in step S1 in the organic solvent is 0.1 to 0.5mmol/ml.

Preferably, the concentration of aryl triflate is 0.2 mmol/ml.

Further, a method for electrochemical synthesis of arylsulfonyl fluoride compounds: the concentration of the reaction medium described in step S1 in the organic solvent is 0.01~0.1mmol/ml; the reaction medium is 9,10 -Dicyananthracene.

Preferably, the concentration of 9,10-dicyananthracene is 0.04mmol/ml.

Further, a method for electrochemical synthesis of arylsulfonyl fluoride compounds: the concentration of the electrolyte described in step S1 in the organic solvent is 0.01~0.1mmol/ml; the electrolyte is ^nBu ₄ NClO ₄ .

Preferably, the concentration of ^nBu ₄ NClO ₄ is 0.05mmol/ml.

Further, a method for electrochemical synthesis of aromatic sulfonyl fluoride compounds: acetonitrile is selected as the organic solvent.

Further, a method for electrochemical synthesis of arylsulfonyl fluoride compounds: step S2, insert a platinum electrode as a positive electrode and an RVC electrode as a negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 10 to 15 mA for electrochemistry. reaction, and the electrochemical reaction time is 1 to 3 hours.

Further, a method of electrochemically synthesizing arylsulfonyl fluoride compounds: the extracting agent used in step S3 is ethyl acetate.

Further, a method for electrochemically synthesizing arylsulfonyl fluoride compounds: Step S3 uses column chromatography for purification.

Further, a method for electrochemical synthesis of arylsulfonyl fluoride compounds: the arylsulfonyl fluoride compounds obtained in step S3 are p-toluenesulfonyl fluoride, p-phenylbenzenesulfonyl fluoride, and p-methoxybenzenesulfonyl fluoride. One of fluorine, m-tert-butylbenzenesulfonyl fluoride, 3-methyl-4-sulfonyl fluoride benzoate methyl ester, and 2-naphthalenesulfonyl fluoride.

(p-Toluenesulfonyl fluoride),/> (p-phenylbenzenesulfonyl fluoride), (p-methoxybenzenesulfonyl fluoride),/> (m-tert-butylbenzenesulfonyl fluoride), (Methyl 3-methyl-4-sulfonylfluorobenzoate),/> (2-Naphthalenesulfonyl fluoride).

Beneficial effects of the present invention:

(1) The synthesis steps provided by the present invention are simple and solve the problems of using metal reagents, expensive metal catalysts, light sources and narrow substrate ranges in conventional synthesis methods. The electrochemical legal method provided by the invention only needs to be carried out at room temperature, the reaction conditions are mild, and there is no metal residue in the product. Since the electrochemical reaction only requires electricity and does not require complex photochemical reaction equipment, the synthesis method of the present invention has low requirements for instruments and equipment. In addition, electric energy is directly used in the reaction without energy conversion, which also reduces the reaction cost to a certain extent.

(2) The synthesis method of the present invention uses aryl triflate, DABSO and KHF ₂ as raw materials, 9,10-dicyananthracene as the medium and acetonitrile as the solvent, and prepares the aryl trifluoromethanesulfonate through electrochemical methods. Sulfonyl fluoride compounds have a high yield, and the yield can reach more than 60%.

(3) Compared with traditional synthesis methods, the synthesis method of the present invention does not have high requirements for instruments and equipment, does not use metal catalysts, saves costs, has mild reaction conditions, simple operating steps, and short reaction time, and can be applied in scientific research , medical, industrial and other fields.

Detailed ways

The technical solution of the present invention will be described clearly and completely below with reference to specific embodiments. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application or uses. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present invention.

Provided is a method for electrochemical synthesis of aromatic sulfonyl fluoride compounds, including the following steps:

S1. Under an inert atmosphere, mix the reaction raw materials aryl triflate, DABSO and potassium hydrogen fluoride in the electrolytic cell;

Then the reaction medium and electrolyte are added to the electrolytic tank, and then an organic solvent is added for dissolution;

S2. Insert an electrode into the electrolytic cell and energize it for electrochemical reaction;

S3. Extract, dry and purify the product obtained from the reaction to obtain an arylsulfonyl fluoride compound.

The reaction process of the above synthesis method is as follows:

Among them: 1 represents aryl triflate, 2 represents DABSO, M-1 represents 9,10-dicyananthracene, MeCN represents acetonitrile, Ar represents aryl, -OTf represents triflate.

Example 1

A method for electrochemical synthesis of arylsulfonyl fluoride compounds (specifically, the synthesis of p-toluenesulfonyl fluoride), which is characterized in that the method includes the following steps:

S1. Under nitrogen atmosphere, add 0.20 mmol of Add 0.15mmol DABSO and 0.60mmol potassium hydrogen fluoride (KHF ₂ ) into a 10.0ml diaphragm-free electrolytic cell;

Then, 0.04 mmol of reaction medium (9,10-dicyananthracene) and 0.05 mmol of electrolyte ( ⁿ Bu ₄ NClO ₄ ) were added to the electrolytic cell, and then 1.0 ml of organic solvent (acetonitrile) was added and stirred to dissolve 10 minute;

S2. Insert a platinum (Pt) electrode as the positive electrode and the RVC electrode as the negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 12 mA to perform an electrochemical reaction for 3 hours;

S3. After the reaction is completed, add the reaction solution to 10 ml of ethyl acetate, wash it twice with 2.5 ml of water, extract, then dry the organic phase with anhydrous sodium sulfate, and then separate it through column chromatography to obtain 26.1 mg of paraben. Toluenesulfonyl fluoride, the calculated yield is 75%, and the structural formula of the obtained product p-toluenesulfonyl fluoride is:

¹ HNMR (500MHz, CDCl ₃ ) δ7.89 (dd, J＝8.4, 1.7Hz, 2H), 7.42 (d, J＝8.1Hz, 2H), 2.49 (s, 3H). ¹³ CNMR (126MHz, CDCl ₃ ) δ 147.1, 130.3, 130.1 (d, J = 19 Hz), 128.4, 21.8. ¹⁹ FNMR (376 MHz, Chloroform-d) δ 66.30.

Example 2

A method for electrochemical synthesis of arylsulfonyl fluoride compounds (specifically, the synthesis of p-phenylbenzenesulfonyl fluoride), which is characterized in that the method includes the following steps:

S1. Under nitrogen atmosphere, add 0.20 mmol of Add 0.15mmol DABSO and 0.60mmol potassium hydrogen fluoride (KHF ₂ ) into a 10.0ml diaphragm-free electrolytic cell;

Then, 0.04 mmol of reaction medium (9,10-dicyananthracene) and 0.05 mmol of electrolyte ( ⁿ Bu ₄ NClO ₄ ) were added to the electrolytic cell, and then 1.0 ml of organic solvent (acetonitrile) was added and stirred to dissolve 10 minute;

S2. Insert a platinum (Pt) electrode as the positive electrode and the RVC electrode as the negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 12 mA to perform an electrochemical reaction for 3 hours;

S3. After the reaction is completed, add the reaction solution to 10 ml of ethyl acetate, wash it twice with 2.5 ml of water, extract, then dry the organic phase with anhydrous sodium sulfate, and then separate it through column chromatography to obtain 38.2 mg of paraben. Phenylbenzenesulfonyl fluoride, the calculated yield is 81%, and the structural formula of the obtained product phenylbenzenesulfonyl fluoride is:

¹ HNMR(500MHz, CDCl ₃ )δ8.10–8.01(m,2H),7.85–7.73(m,2H),7.67–7.59(m,2H),7.55–7.41(m,3H). ¹³ CNMR(126MHz , CDCl ₃ ) δ 148.7, 138.5, 131.4 (d, J = 20Hz), 129.3, 129.2, 129.0, 128.2, 127.5. ¹⁹ FNMR (376MHz, CDCl ₃ ) δ 66.52.

Example 3

A method for electrochemical synthesis of arylsulfonyl fluoride compounds (specifically, the synthesis of p-methoxybenzenesulfonyl fluoride), which is characterized in that the method includes the following steps:

S1. Under nitrogen atmosphere, add 0.20 mmol of Add 0.15mmol DABSO and 0.60mmol potassium hydrogen fluoride (KHF ₂ ) into a 10.0ml diaphragm-free electrolytic cell;

Then, 0.04 mmol of reaction medium (9,10-dicyananthracene) and 0.05 mmol of electrolyte ( ⁿ Bu ₄ NClO ₄ ) were added to the electrolytic cell, and then 1.0 ml of organic solvent (acetonitrile) was added and stirred to dissolve 10 minute;

S2. Insert a platinum (Pt) electrode as the positive electrode and the RVC electrode as the negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 12 mA to perform an electrochemical reaction for 3 hours;

S3. After the reaction is completed, add the reaction solution to 10 ml of ethyl acetate, wash it twice with 2.5 ml of water, extract, then dry the organic phase with anhydrous sodium sulfate, and then separate it by column chromatography to obtain 30.1 mg of paraben. Phenylbenzenesulfonyl fluoride, the calculated yield is 79%, and the structural formula of the obtained product p-methoxybenzenesulfonyl fluoride is:

¹ HNMR (500MHz, CDCl ₃ ) δ7.89 (dd, J＝8.4, 1.7Hz, 2H), 7.42 (d, J＝8.1Hz, 2H), 2.49 (s, 3H). ¹³ CNMR (126MHz, CDCl ₃ )δ147.1, 130.3, 130.1 (d, J=2Hz), 128.4, 21.8. _. ¹⁹ FNMR (471MHz, CDCl ₃ )δ66.30.

Example 4

A method for electrochemical synthesis of arylsulfonyl fluoride compounds (specifically, synthesis of m-tert-butylbenzenesulfonyl fluoride), characterized in that the method includes the following steps:

S1. Under nitrogen atmosphere, add 0.20 mmol of Add 0.15mmol DABSO and 0.60mmol potassium hydrogen fluoride (KHF ₂ ) into a 10.0ml diaphragm-free electrolytic cell;

Then, 0.04 mmol of reaction medium (9,10-dicyananthracene) and 0.05 mmol of electrolyte ( ⁿ Bu ₄ NClO ₄ ) were added to the electrolytic cell, and then 1.0 ml of organic solvent (acetonitrile) was added and stirred to dissolve 10 minute;

S2. Insert a platinum (Pt) electrode as the positive electrode and the RVC electrode as the negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 12 mA to perform an electrochemical reaction for 3 hours;

S3. After the reaction is completed, add the reaction solution to 10 ml of ethyl acetate, wash it twice with 2.5 ml of water, extract, then dry the organic phase with anhydrous sodium sulfate, and then separate it through column chromatography to obtain 34.6 mg of paraben. Phenylbenzenesulfonyl fluoride, the calculated yield is 80%, and the structural formula of the obtained product m-tert-butylbenzenesulfonyl fluoride is:

¹ HNMR (500MHz, CDCl ₃ ) δ8.01 (s, 1H), 7.83 (t, J = 7.0 Hz, 2H), 7.57 (t, J = 7.9 Hz, 1H), 1.37 (s, 9H). ¹³ CNMR (126MHz, CDCl ₃ ) δ 153.6, 132.9, 132.8, 129.5, 125.6, 125.1, 35.2, 31.0. ¹⁹ FNMR (471MHz, CDCl ₃ ) δ 65.92.

Example 5

A method for electrochemical synthesis of aromatic sulfonyl fluoride compounds (specifically, the synthesis of methyl 3-methyl-4-sulfonyl fluoride benzoate), which is characterized in that the method includes the following steps:

S1. Under nitrogen atmosphere, add 0.20 mmol of Add 0.15mmol DABSO and 0.60mmol potassium hydrogen fluoride (KHF ₂ ) into a 10.0ml diaphragm-free electrolytic cell;

Then, 0.04 mmol of reaction medium (9,10-dicyananthracene) and 0.05 mmol of electrolyte ( ⁿ Bu ₄ NClO ₄ ) were added to the electrolytic cell, and then 1.0 ml of organic solvent (acetonitrile) was added and stirred to dissolve 10 minute;

S2. Insert a platinum (Pt) electrode as the positive electrode and the RVC electrode as the negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 12 mA to perform an electrochemical reaction for 3 hours;

S3. After the reaction is completed, add the reaction solution to 10 ml of ethyl acetate, wash it twice with 2.5 ml of water, extract, then dry the organic phase with anhydrous sodium sulfate, and then separate it through column chromatography to obtain 36.7 mg of paraben. Phenylbenzenesulfonyl fluoride, the calculated yield is 65%, and the structural formula of the obtained product 3-methyl-4-sulfonyl fluoride benzoic acid methyl ester is

¹ HNMR (400MHz, CDCl ₃ ) δ8.16–8.08(m,2H),8.04(dt,J＝8.2,1.7Hz,1H),3.98(s,3H),2.82–2.69(m,3H). ¹³ CNMR (101MHz, CDCl ₃ ) δ 165.1, 139.4, 136.0, 135.9 (J=23Hz), 133.7, 130.2, 127.5, 52.9, 20.3. ¹⁹ FNMR (376MHz, CDCl ₃ ) δ 60.26.

Example 6

A method for electrochemical synthesis of arylsulfonyl fluoride compounds (specifically, the synthesis of 2-naphthalenesulfonyl fluoride), which is characterized in that the method includes the following steps:

S1. Under nitrogen atmosphere, add 0.20 mmol of Add 0.15mmol DABSO and 0.60mmol potassium hydrogen fluoride (KHF ₂ ) into a 10.0ml diaphragm-free electrolytic cell;

Then, 0.04 mmol of reaction medium (9,10-dicyananthracene) and 0.05 mmol of electrolyte ( ⁿ Bu ₄ NClO ₄ ) were added to the electrolytic cell, and then 1.0 ml of organic solvent (acetonitrile) was added and stirred to dissolve 10 minute;

S2. Insert a platinum (Pt) electrode as the positive electrode and the RVC electrode as the negative electrode in the electrolytic cell, and then pass a constant voltage direct current of 12 mA to perform an electrochemical reaction for 3 hours;

S3. After the reaction is completed, add the reaction solution to 10 ml of ethyl acetate, wash it twice with 2.5 ml of water, extract, and then dry the organic phase with anhydrous sodium sulfate, and then separate it through column chromatography to obtain 31.2 mg of paraben. Phenylbenzenesulfonyl fluoride, the calculated yield is 76%, and the structural formula of the obtained product 2-naphthalenesulfonyl fluoride is:

¹ HNMR (400MHz, CDCl ₃ ) δ8.54 (d, J = 1.9Hz, 1H), 8.09–7.84 (m, 4H), 7.73-7.62 (m, 2H). ¹³ CNMR (101MHz, CDCl ₃ ) δ136. 0,131.7,130.9,130.4,130.1,129.8,129.6,128.3,128.1,122.1. ¹⁹ FNMR (376MHz, CDCl ₃ ) δ66.37.

The difference between the above-mentioned Examples 1 to 5 is that the raw material aryl triflate used is different in type, the rest of the reaction conditions are the same, and the products obtained are different.

Example 6

The difference between Example 6 and Example 1 is that the ratio and concentration of the raw materials are different, and the rest are the same as Example 1; the yield of Example 6 is 73%.

In the above embodiment 1, the molar ratio between aryl triflate, DABSO and potassium fluoride is 4:3:12; the concentration of aryl triflate is 0.2mmol/ml; 9,10 - The concentration of dicyanoanthracene is 0.04mmol/ml; the concentration of ^nBu ₄ NClO ₄ is 0.05mmol/ml.

In Example 6, the molar ratio between aryl triflate, DABSO and potassium fluoride was adjusted to 2:1:3; the concentration of aryl triflate was adjusted to 0.1mmol/ml; Adjust the concentration of 9,10-dicyananthracene to 0.02mmol/ml; adjust the concentration of ^nBu ₄ NClO ₄ to 0.03mmol/ml.

Example 7

The difference between Example 7 and Example 1 is that the ratio and concentration of the raw materials are different, and the rest are the same as Example 1; the yield of Example 7 is 74.5%.

Example 7 Adjust the molar ratio between aryl triflate, DABSO and potassium hydrofluoride to 3:1:5; adjust the concentration of aryl triflate to 0.5mmol/ml; The concentration of 9,10-dicyananthracene was adjusted to 0.1mmol/ml; the concentration of ^nBu ₄ NClO ₄ was adjusted to 0.1mmol/ml.

The invention provides a method for electrochemically synthesizing aromatic sulfonyl fluoride compounds using phenol derivatives as raw materials. The synthesis steps of this method are simple. Compared with traditional activated phenols and their derivatives, C-O bonds are broken to prepare aromatic radicals. As for the synthesis method of sulfonyl fluoride compounds, the synthesis method provided by the present invention does not have high requirements on instruments and equipment, does not use metal catalysts, saves costs, has mild reaction conditions, simple operating steps, short reaction time, and high yield.

The above-mentioned preferred embodiments of the present invention are only used to explain the present invention and are not intended to limit the present invention. Any obvious changes or modifications derived from the technical solutions of the present invention are still within the protection scope of the present invention.

Claims (10)

1. A method for electrochemically synthesizing an aromatic sulfonyl fluoride compound, comprising the steps of:

s1, mixing reaction raw materials including aryl triflate, DABSO and potassium bifluoride in an electrolytic tank under an inert atmosphere;

then adding a reaction medium and an electrolyte into the electrolytic tank, and then adding an organic solvent for dissolution;

s2, inserting electrodes into the electrolytic tank, and electrifying to perform electrochemical reaction;

s3, extracting, drying and purifying after the reaction to obtain the aryl sulfonyl fluoride compound.

2. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the molar ratio of aromatic triflate, DABSO and potassium fluorohydride in step S1 is (1-3): 1: (3-5).

3. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the concentration of the aromatic triflate in the organic solvent in step S1 is 0.1 to 0.5mmol/ml.

4. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the concentration of the reaction medium in the organic solvent in step S1 is 0.02 to 0.1mmol/ml; the reaction medium is 9, 10-dicyanoanthracene.

5. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the concentration of the electrolyte in the organic solvent in step S1 is 0.03 to 0.1mmol/ml; the electrolyte is ⁿ Bu ₄ NClO ₄ 。

6. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the organic solvent is acetonitrile.

7. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein in step S2, a platinum electrode is inserted as a positive electrode and an RVC electrode is inserted as a negative electrode in the electrolytic cell, and then a constant voltage direct current of 10-15 mA is applied to perform electrochemical reaction for 1-3 hours.

8. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the extractant used in step S3 is ethyl acetate.

9. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein step S3 is a purification by column chromatography.

10. The method for electrochemical synthesis of an aromatic sulfonyl fluoride compound according to claim 1, wherein the aromatic sulfonyl fluoride compound obtained in step S3 is one of p-toluenesulfonyl fluoride, p-phenylbenzenesulfonyl fluoride, p-methoxybenzenesulfonyl fluoride, m-tert-butylbenzenesulfonyl fluoride, methyl 3-methyl-4-sulfonyl fluorobenzoate and 2-naphthalenesulfonyl fluoride.