CN117045851A - Antibacterial liquid spray dressing - Google Patents

Antibacterial liquid spray dressing Download PDF

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Publication number
CN117045851A
CN117045851A CN202210487369.4A CN202210487369A CN117045851A CN 117045851 A CN117045851 A CN 117045851A CN 202210487369 A CN202210487369 A CN 202210487369A CN 117045851 A CN117045851 A CN 117045851A
Authority
CN
China
Prior art keywords
parts
liquid spray
spray dressing
weight
dressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN202210487369.4A
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Chinese (zh)
Inventor
于景堂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Yifei Medical Technology Co ltd
Original Assignee
Shanghai Yifei Medical Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Yifei Medical Technology Co ltd filed Critical Shanghai Yifei Medical Technology Co ltd
Priority to CN202210487369.4A priority Critical patent/CN117045851A/en
Publication of CN117045851A publication Critical patent/CN117045851A/en
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/232Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides an antibacterial liquid spray dressing. Comprises the following components in parts by weight: 20-28 parts of chitosan, 8-12 parts of carboxymethyl cellulose, 4-6 parts of methyl cyclodextrin, 1-3 parts of beta-hydroxy isovaleric acid, 1-3 parts of pyrrolidone sodium carboxylate, 1-3 parts of butyl hydroxy benzoate, 2-4 parts of p-ethyl acetophenone, 0.2-0.4 part of tobramycin, 0.2-0.6 part of gentamicin and 1-2 parts of sodium stearoyl lactate. The invention introduces the antibacterial agent with composite components on the premise of not affecting the performance of the dressing, and integrates the antibacterial agent with the composite formula, thereby constructing a brand new dressing formula. Specifically, the invention takes chitosan, carboxymethyl cellulose and methyl cyclodextrin as main components, and introduces beta-hydroxy isovaleric acid, sodium pyrrolidone carboxylate, butyl hydroxy benzene, p-ethyl acetophenone and other components to improve the curing effect, and simultaneously, tobramycin and gentamicin are added, thereby safely achieving the broad-spectrum antibacterial effect. The invention has reasonable formula and good antibacterial effect, and has outstanding advantage technology.

Description

Antibacterial liquid spray dressing
Technical Field
The invention relates to the technical field of liquid dressing, in particular to an antibacterial liquid spray dressing.
Background
The liquid dressing is a nursing agent for skin wound surface, and forms a protective layer on the surface of the wound surface to play a physical barrier role, so that the nursing agent is used for nursing superficial wound surface and surrounding skin. The liquid dressing has the function of disinfection, can directly act on pathogens, has the function of inhibiting most bacteria, viruses and protozoa, including staphylococcus aureus, escherichia coli, hemolytic streptococcus and the like, and can form a layer of protective film to protect wounds when being sprayed on wound surfaces, and simultaneously isolate the wounds from the outside, prevent the invasion of external pathogens and kill the bacteria around the wounds. Can be used for treating wound of abdomen and perineum, and has effects of promoting wound healing and preventing infection.
In the prior art, a protective film is formed on the surface of a wound when the liquid auxiliary material is sprayed on the surface of the wound, and the protective film can play a role in sterilizing, in addition, a moist environment can be formed on the surface of the wound, so that the healing of the wound can be promoted, under the traditional concept, people usually consider that the wound should be kept in a dry environment, otherwise, the wound is easy to inflame, but the moist environment is easier to promote the healing of the wound as the medical research finds, and the moist environment can also lighten the pain of the wound, so that the liquid dressing gradually replaces the traditional bandaging mode, can be accepted by people more easily, and is convenient to use. Currently, conventional liquid dressings have made great progress in promoting wound healing and the like, but their antibacterial efficacy has yet to be improved.
Disclosure of Invention
Aiming at the technical defects of the prior art, the invention provides an antibacterial liquid spray dressing to solve the technical problem that the antibacterial property of the conventional liquid dressing needs to be improved.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
an antibacterial liquid spray dressing comprises the following components in parts by weight: 20-28 parts of chitosan, 8-12 parts of carboxymethyl cellulose, 4-6 parts of methyl cyclodextrin, 1-3 parts of beta-hydroxy isovaleric acid, 1-3 parts of pyrrolidone sodium carboxylate, 1-3 parts of butyl hydroxy benzoate, 2-4 parts of p-ethyl acetophenone, 0.2-0.4 part of tobramycin, 0.2-0.6 part of gentamicin and 1-2 parts of sodium stearoyl lactate.
Preferably, the liquid spray dressing further comprises 1 to 3 parts by weight of xylitol fatty acid ester.
Preferably, the liquid spray dressing further comprises 2 to 4 parts by weight of L-ureido alanine.
Preferably, the liquid spray dressing further comprises 1 to 5 parts by weight of diacetone acrylamide.
Preferably, the liquid spray dressing further comprises 1 to 3 parts by weight of acetyl n-propanol.
Preferably, the liquid spray dressing comprises the following components in parts by weight: 24 parts of chitosan, 10 parts of carboxymethyl cellulose, 5 parts of methyl cyclodextrin, 2 parts of beta-hydroxy isovaleric acid, 2 parts of pyrrolidone sodium carboxylate, 2 parts of butyl oxybenzene, 3 parts of p-ethyl acetophenone, 0.3 part of tobramycin, 0.4 part of gentamicin and 1.5 parts of sodium stearoyl lactate.
Preferably, the liquid spray dressing comprises the following components in parts by weight: 24 parts of chitosan, 10 parts of carboxymethyl cellulose, 5 parts of methyl cyclodextrin, 2 parts of beta-hydroxy isovaleric acid, 2 parts of pyrrolidone sodium carboxylate, 2 parts of butyl hydroxybenzoate, 3 parts of p-ethyl acetophenone, 0.3 part of tobramycin, 0.4 part of gentamicin, 1.5 parts of sodium stearoyl lactate, 2 parts of xylitol fatty acid ester, 3 parts of L-ureidoalanine, 3 parts of diacetone acrylamide and 2 parts of acetyl n-propanol.
The invention provides an antibacterial liquid spray dressing. According to the technical scheme, the antibacterial agent with the composite components is introduced on the premise of not affecting the performance of the dressing, and the antibacterial agent is integrated by adopting a composite formula, so that a brand new dressing formula is constructed. Specifically, the invention takes chitosan, carboxymethyl cellulose and methyl cyclodextrin as main components, and introduces beta-hydroxy isovaleric acid, sodium pyrrolidone carboxylate, butyl hydroxy benzene, p-ethyl acetophenone and other components to improve the curing effect, and simultaneously, tobramycin and gentamicin are added, thereby safely achieving the broad-spectrum antibacterial effect. The invention has reasonable formula and good antibacterial effect, and has outstanding advantage technology.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail. In order to avoid unnecessary detail, well-known structures or functions will not be described in detail in the following embodiments. Approximating language, as used in the following examples, may be applied to create a quantitative representation that could permissibly vary without resulting in a change in the basic function. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
Example 1
An antibacterial liquid spray dressing comprises the following components in parts by weight: 24 parts of chitosan, 10 parts of carboxymethyl cellulose, 5 parts of methyl cyclodextrin, 2 parts of beta-hydroxy isovaleric acid, 2 parts of pyrrolidone sodium carboxylate, 2 parts of butyl hydroxybenzoate, 3 parts of p-ethyl acetophenone, 0.3 part of tobramycin, 0.4 part of gentamicin, 1.5 parts of sodium stearoyl lactate, 2 parts of xylitol fatty acid ester, 3 parts of L-ureidoalanine, 3 parts of diacetone acrylamide and 2 parts of acetyl n-propanol.
Example 2
An antibacterial liquid spray dressing comprises the following components in parts by weight: 24 parts of chitosan, 10 parts of carboxymethyl cellulose, 5 parts of methyl cyclodextrin, 2 parts of beta-hydroxy isovaleric acid, 2 parts of pyrrolidone sodium carboxylate, 2 parts of butyl oxybenzene, 3 parts of p-ethyl acetophenone, 0.3 part of tobramycin, 0.4 part of gentamicin and 1.5 parts of sodium stearoyl lactate
Example 3
An antibacterial liquid spray dressing comprises the following components in parts by weight: 20 parts of chitosan, 8 parts of carboxymethyl cellulose, 4 parts of methyl cyclodextrin, 1 part of beta-hydroxy isovaleric acid, 1 part of pyrrolidone sodium carboxylate, 1 part of butyl oxybenzene, 2 parts of p-ethyl acetophenone, 0.2 part of tobramycin, 0.2 part of gentamicin and 1 part of sodium stearoyl lactate.
Example 4
An antibacterial liquid spray dressing comprises the following components in parts by weight: 28 parts of chitosan, 12 parts of carboxymethyl cellulose, 6 parts of methyl cyclodextrin, 3 parts of beta-hydroxy isovaleric acid, 3 parts of sodium pyrrolidone carboxylate, 3 parts of butyl oxybenzene, 4 parts of p-ethyl acetophenone, 0.4 part of tobramycin, 0.6 part of gentamicin and 2 parts of sodium stearyl lactate.
The foregoing describes the embodiments of the present invention in detail, but the description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the scope of the present invention should be included in the protection scope of the present invention.

Claims (7)

1. An antibacterial liquid spray dressing is characterized by comprising the following components in parts by weight: 20-28 parts of chitosan, 8-12 parts of carboxymethyl cellulose, 4-6 parts of methyl cyclodextrin, 1-3 parts of beta-hydroxy isovaleric acid, 1-3 parts of pyrrolidone sodium carboxylate, 1-3 parts of butyl hydroxy benzoate, 2-4 parts of p-ethyl acetophenone, 0.2-0.4 part of tobramycin, 0.2-0.6 part of gentamicin and 1-2 parts of sodium stearoyl lactate.
2. An antimicrobial liquid spray dressing according to claim 1, wherein the liquid spray dressing further comprises 1 to 3 parts by weight of xylitol fatty acid ester.
3. An antimicrobial liquid spray dressing according to claim 1, wherein the liquid spray dressing further comprises 2 to 4 parts by weight of L-ureido alanine.
4. An antimicrobial liquid spray dressing according to claim 1, wherein the liquid spray dressing further comprises 1 to 5 parts by weight of diacetone acrylamide.
5. An antimicrobial liquid spray dressing according to claim 1, wherein the liquid spray dressing further comprises 1 to 3 parts by weight of acetyl n-propanol.
6. An antimicrobial liquid spray dressing according to claim 1, characterized in that the liquid spray dressing consists of the following components in parts by weight: 24 parts of chitosan, 10 parts of carboxymethyl cellulose, 5 parts of methyl cyclodextrin, 2 parts of beta-hydroxy isovaleric acid, 2 parts of pyrrolidone sodium carboxylate, 2 parts of butyl oxybenzene, 3 parts of p-ethyl acetophenone, 0.3 part of tobramycin, 0.4 part of gentamicin and 1.5 parts of sodium stearoyl lactate.
7. An antimicrobial liquid spray dressing according to claim 1, characterized in that the liquid spray dressing consists of the following components in parts by weight: 24 parts of chitosan, 10 parts of carboxymethyl cellulose, 5 parts of methyl cyclodextrin, 2 parts of beta-hydroxy isovaleric acid, 2 parts of pyrrolidone sodium carboxylate, 2 parts of butyl hydroxybenzoate, 3 parts of p-ethyl acetophenone, 0.3 part of tobramycin, 0.4 part of gentamicin, 1.5 parts of sodium stearoyl lactate, 2 parts of xylitol fatty acid ester, 3 parts of L-ureidoalanine, 3 parts of diacetone acrylamide and 2 parts of acetyl n-propanol.
CN202210487369.4A 2022-05-06 2022-05-06 Antibacterial liquid spray dressing Withdrawn CN117045851A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210487369.4A CN117045851A (en) 2022-05-06 2022-05-06 Antibacterial liquid spray dressing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210487369.4A CN117045851A (en) 2022-05-06 2022-05-06 Antibacterial liquid spray dressing

Publications (1)

Publication Number Publication Date
CN117045851A true CN117045851A (en) 2023-11-14

Family

ID=88661350

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210487369.4A Withdrawn CN117045851A (en) 2022-05-06 2022-05-06 Antibacterial liquid spray dressing

Country Status (1)

Country Link
CN (1) CN117045851A (en)

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Application publication date: 20231114