CN117016558A - Emulsion containing fosthiazate and fluopyram and preparation method thereof - Google Patents
Emulsion containing fosthiazate and fluopyram and preparation method thereof Download PDFInfo
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- CN117016558A CN117016558A CN202311027354.0A CN202311027354A CN117016558A CN 117016558 A CN117016558 A CN 117016558A CN 202311027354 A CN202311027354 A CN 202311027354A CN 117016558 A CN117016558 A CN 117016558A
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- China
- Prior art keywords
- emulsifiable concentrate
- polyoxyethylene ether
- percent
- fosthiazate
- fluopyram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DUFVKSUJRWYZQP-UHFFFAOYSA-N fosthiazate Chemical compound CCC(C)SP(=O)(OCC)N1CCSC1=O DUFVKSUJRWYZQP-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000005959 Fosthiazate Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- KVDJTXBXMWJJEF-UHFFFAOYSA-N fluopyram Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CCNC(=O)C1=CC=CC=C1C(F)(F)F KVDJTXBXMWJJEF-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 239000005783 Fluopyram Substances 0.000 title claims abstract description 34
- 239000000839 emulsion Substances 0.000 title description 10
- 239000004495 emulsifiable concentrate Substances 0.000 claims abstract description 41
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 16
- 239000002904 solvent Substances 0.000 claims abstract description 15
- 239000003381 stabilizer Substances 0.000 claims abstract description 12
- 239000002270 dispersing agent Substances 0.000 claims abstract description 8
- 239000012747 synergistic agent Substances 0.000 claims abstract description 8
- 238000009736 wetting Methods 0.000 claims abstract description 8
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 28
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 11
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 6
- TVFWYUWNQVRQRG-UHFFFAOYSA-N 2,3,4-tris(2-phenylethenyl)phenol Chemical compound C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 TVFWYUWNQVRQRG-UHFFFAOYSA-N 0.000 claims description 4
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical compound NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- 229960001777 castor oil Drugs 0.000 claims description 4
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 claims description 4
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 claims description 4
- 239000010696 ester oil Substances 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 235000019198 oils Nutrition 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- FPMPZEHRIIAVCO-UHFFFAOYSA-N 3-(2-phenylethyl)-2-(3-phenylpropyl)phenol Chemical compound C(CC1=CC=CC=C1)C=1C(=C(C=CC1)O)CCCC1=CC=CC=C1 FPMPZEHRIIAVCO-UHFFFAOYSA-N 0.000 claims description 2
- OTYYBJNSLLBAGE-UHFFFAOYSA-N CN1C(CCC1)=O.[N] Chemical compound CN1C(CCC1)=O.[N] OTYYBJNSLLBAGE-UHFFFAOYSA-N 0.000 claims description 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 2
- PLUHAVSIMCXBEX-UHFFFAOYSA-N azane;dodecyl benzenesulfonate Chemical compound N.CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 PLUHAVSIMCXBEX-UHFFFAOYSA-N 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 125000004492 methyl ester group Chemical group 0.000 claims description 2
- 150000004702 methyl esters Chemical class 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 230000001502 supplementing effect Effects 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- UZRCGISJYYLJMA-UHFFFAOYSA-N phenol;styrene Chemical compound OC1=CC=CC=C1.C=CC1=CC=CC=C1 UZRCGISJYYLJMA-UHFFFAOYSA-N 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- HGXBRUKMWQGOIE-AFHBHXEDSA-N (+)-pinoresinol Chemical group C1=C(O)C(OC)=CC([C@@H]2[C@@H]3[C@@H]([C@H](OC3)C=3C=C(OC)C(O)=CC=3)CO2)=C1 HGXBRUKMWQGOIE-AFHBHXEDSA-N 0.000 claims 1
- 125000002243 cyclohexanonyl group Chemical group *C1(*)C(=O)C(*)(*)C(*)(*)C(*)(*)C1(*)* 0.000 claims 1
- OHOPKHNWLCMLSW-UHFFFAOYSA-N pinoresinol Natural products C1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C(CO)C(O)=CC=3)CO2)=C1 OHOPKHNWLCMLSW-UHFFFAOYSA-N 0.000 claims 1
- 235000007221 pinoresinol Nutrition 0.000 claims 1
- BURBOJZOZGMMQF-UHFFFAOYSA-N xanthoxylol Natural products C1=C(O)C(OC)=CC=C1C1C(COC2C=3C=C4OCOC4=CC=3)C2CO1 BURBOJZOZGMMQF-UHFFFAOYSA-N 0.000 claims 1
- 239000008096 xylene Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 19
- 201000010099 disease Diseases 0.000 abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 13
- 239000004480 active ingredient Substances 0.000 abstract description 10
- 241000243785 Meloidogyne javanica Species 0.000 abstract description 6
- 241000607479 Yersinia pestis Species 0.000 abstract description 4
- 230000015556 catabolic process Effects 0.000 abstract description 4
- 238000006731 degradation reaction Methods 0.000 abstract description 4
- 206010059866 Drug resistance Diseases 0.000 abstract description 3
- 238000005338 heat storage Methods 0.000 abstract description 3
- 238000004945 emulsification Methods 0.000 abstract description 2
- MGOXMUZCJGPUAN-UHFFFAOYSA-N phosphane;1,3-thiazole Chemical compound P.C1=CSC=N1 MGOXMUZCJGPUAN-UHFFFAOYSA-N 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 35
- 240000008067 Cucumis sativus Species 0.000 description 18
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 16
- 241000244206 Nematoda Species 0.000 description 13
- 244000305550 Streptopus amplexifolius Species 0.000 description 13
- 235000001231 Streptopus amplexifolius Nutrition 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 241000238631 Hexapoda Species 0.000 description 10
- 241000196324 Embryophyta Species 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 7
- 239000000575 pesticide Substances 0.000 description 7
- 239000002689 soil Substances 0.000 description 6
- 239000005645 nematicide Substances 0.000 description 5
- -1 (RS) -S-sec-butyl-O-ethyl-2-oxo-1, 3-thiazolin-3-yl thiophosphate Chemical compound 0.000 description 4
- 239000012752 auxiliary agent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000003973 irrigation Methods 0.000 description 3
- 230000002262 irrigation Effects 0.000 description 3
- 230000001069 nematicidal effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000219112 Cucumis Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- 235000009849 Cucumis sativus Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 241000243786 Meloidogyne incognita Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 240000003768 Solanum lycopersicum Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000012271 agricultural production Methods 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000003337 fertilizer Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 239000005782 Fluopicolide Substances 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 244000037666 field crops Species 0.000 description 1
- GBOYJIHYACSLGN-UHFFFAOYSA-N fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 239000003986 organophosphate insecticide Substances 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052572 stoneware Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/26—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds
- A01N57/32—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds containing heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P5/00—Nematocides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a thiazole phosphine and fluopyram-containing emulsifiable concentrate and a preparation method thereof, wherein the emulsifiable concentrate comprises the following components in percentage by weight: 1 to 30 percent of fosthiazate, 0.01 to 20 percent of fluopyram, 3 to 30 percent of emulsifying agent, 5 to 15 percent of wetting dispersant, 10 to 25 percent of synergistic agent, 1 to 8 percent of stabilizer and 100 percent of solvent. The emulsifiable concentrate disclosed by the invention has the advantages of low degradation rate of active ingredients, good emulsification effect, low temperature and good heat storage stability, has a good control effect on root-knot nematode diseases, can delay the drug resistance of target pests, and is better in safety on target crops.
Description
Technical Field
The invention belongs to the field of pesticide preparations, and particularly relates to a fosthiazate and fluopyram-containing emulsifiable concentrate and a preparation method thereof.
Background
Root knot nematodes are highly specialized omnivorous plant pathogenic nematodes, which are the most widely distributed and most serious plant parasitic nematodes in the world. Root knot nematode disease is an important disease that endangers many crops, such as melons, cucumbers, watermelons, white melons, tomatoes, eggplants, celery, and the like. The infection hazard of the root-knot nematodes also aggravates the occurrence of soil-borne diseases such as fusarium wilt, root rot and the like.
Fluopyram, CAS number: 658066-35-4, english generic name: fluopyram, chemical name: n- {2- [ 3-chloro-5- (trifluoromethyl) -2-pyridyl ] ethyl } -alpha, alpha-trifluoro-o-toluamide is a succinate dehydrogenase inhibitor, inhibits mitochondrial function by destroying complex II in respiratory electron transfer chain, and can be used for grape, nut, pear, vegetable and field crops, gray mold, powdery mildew and the like, and also can be used for preventing and treating root knot nematode disease.
Fosthiazate, CAS no: 98886-44-3, english generic name: fosthiazate, chemical name: (RS) -S-sec-butyl-O-ethyl-2-oxo-1, 3-thiazolin-3-yl thiophosphate with molecular weight 283.3, instability at room temperature, strong odor, and density 1.26g/cm 3 The boiling point is 198 ℃ (66.66 Pa), the solubility in water is 9.85g/L, and the water-soluble organic solvent is dissolved in most organic solvents, is easy to decompose in alkaline environment and is easy to photolyze. Fosthiazate is a broad-spectrum non-fumigating organophosphorus insecticide developed by japan stoneware company. The fosthiazate has the main action mode of inhibiting acetylcholinesterase of target organisms, has systemic property, and can prevent and treat nematodes, aphids, mites, thrips and the like of crops such as vegetables, potatoes, tomatoes, bananas and the like.
CN104585230A discloses a nematicidal composition containing fosthiazate and fluopyram, which comprises the active ingredients of binary combination of the nematicidal composition containing fosthiazate and fluopyram and the balance of auxiliary ingredients, wherein the dosage forms of the nematicidal composition are emulsifiable concentrate, suspending agent, water aqua, wettable powder, water dispersible granule, emulsion in water, microemulsion, granules and microcapsule. Wherein the auxiliary agent for preparing the emulsifiable concentrate is a conventional emulsifying agent, a solvent and a synergistic agent. Because the fosthiazate has poor stability, the fosthiazate preparation and the mixing and the storage requirements thereof are relatively high, the prepared preparation has poor performance in the specific use process, the fosthiazate has poor stability, the problems of layering, precipitation and the like are easy to occur, and the use in agricultural production is seriously influenced.
Secondly, in the actual agricultural production, in order to achieve a good nematode control effect, the main application mode of the fosthiazate single-dose and mixed-dose products is that the fosthiazate single-dose and mixed-dose products are root irrigation or broadcast in soil at a time. As fosthiazate is a poisoning product, if the stress resistance of plants is reduced or the disposable application amount of fosthiazate is too high under the condition of changing the external environment, the root burning phytotoxicity is easy to cause, and the plant growth is further influenced.
Therefore, aiming at the problems, the invention provides the emulsifiable concentrate containing fosthiazate and fluopyram and the preparation method thereof, and the preparation can effectively improve the stability of the pesticide active ingredient and improve the safety of target crops.
Disclosure of Invention
Based on the above circumstances, the invention aims to provide the emulsifiable concentrate containing fosthiazate and fluopyram and the preparation method thereof, wherein the emulsifiable concentrate is mainly used for preventing and controlling root-knot nematode diseases, has reasonable component system, low degradation rate of pesticide effective components, good emulsification effect and good low-temperature stability and heat storage stability, delays the drug resistance of target pests, improves the control effect and simultaneously improves the safety of target crops.
In order to achieve the aim, the invention provides the emulsifiable concentrate containing fosthiazate and fluopyram and the preparation method thereof, wherein the emulsifiable concentrate consists of the following components in percentage by weight: 1 to 30 percent of fosthiazate, 0.01 to 20 percent of fluopyram, 3 to 30 percent of emulsifying agent, 5 to 15 percent of wetting dispersant, 10 to 25 percent of synergistic agent, 1 to 8 percent of stabilizer and 100 percent of solvent;
further, the mass ratio of the fosthiazate to the fluopyram is 1:5-15:1.
Further, the mass ratio of the fosthiazate to the fluopyram is 14:1;
further, the emulsifier is selected from one or more of tristyrylphenol polyoxyethylene ether, dodecylbenzene sulfonate, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkyl succinamide sulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenethylphenylpropyl phenol polyoxyethylene polyoxypropylene ether or tween-80;
further, the emulsifier is selected from one or more of tristyrylphenol polyoxyethylene ether, dodecylbenzene sulfonate, castor oil polyoxyethylene ether, alkyl succinamide sulfonate, alkylphenol polyoxyethylene ether or tween-80;
further, the emulsifier is a mixture of alkylphenol ethoxylates, ammonium dodecyl benzene sulfonate and alkyl succinamide sulfonate;
further, the weight percentage of the emulsifier in the emulsifiable concentrate is 10-20%;
further, the mass ratio of the emulsifying agent is 15%, 16%, 17% and 18%;
further, the wetting dispersant is selected from a mixture consisting of a poly (styrene-phenol-polyoxyethylene ether) phosphate or a fatty amine polyoxyethylene ether;
further, the mass ratio of the poly (styrene-phenol-polyoxyethylene ether) phosphate to the fatty amine polyoxyethylene ether is (2-4) (1-3);
further, the mass ratio of the poly (styrene-phenol-polyoxyethylene ether) phosphate to the fatty amine polyoxyethylene ether is 3:2;
further, the synergistic agent is rosin oil;
further, the synergistic agent accounts for 15-25% of the emulsifiable concentrate by weight;
further, the synergistic agent accounts for 20%, 22%, 23% and 25% of the weight of the emulsifiable concentrate;
further, the solvent is one or more selected from cyclohexanone, solvent oil, dimethylbenzene, acetophenone or azomethyl pyrrolidone;
further, the solvent is a mixture of cyclohexanone or nitrogen methyl pyrrolidone;
further, the stabilizer is selected from any one of block polyether, epoxidized soybean oil or methyl ester oil;
further, the stabilizer is methyl ester oil;
further, the stabilizer accounts for 1 to 5 weight percent of the emulsifiable concentrate;
further, the stabilizer accounts for 3% and 5% of the weight of the emulsifiable concentrate.
The emulsifiable concentrates are commercially available.
The preparation method of the emulsifiable concentrate containing fosthiazate and fluopyram is characterized by comprising the following steps of: dissolving the effective components in the solvent, and then adding the emulsifying agent and other auxiliary agents to uniformly mix.
The invention has the beneficial effects that:
1) According to the invention, a specific emulsifiable concentrate formula system is screened out, so that the prepared emulsifiable concentrate containing fosthiazate and fluopyram can be automatically dispersed in water, the stability is qualified, and the degradation rate of active ingredients is obviously reduced;
2) The emulsifiable concentrate preparation prepared by the invention can delay the drug resistance of target pests and improve the safety of target crops.
Detailed Description
In order to make the technical scheme and advantages of the present invention more apparent, the following detailed description is provided in connection with specific embodiments.
The invention provides a fosthiazate and fluopyram-containing emulsifiable concentrate which comprises the following components in percentage by weight:
| component (A) | Content of |
| Fosthiazate | 1～30％ |
| Fluopicolide | 0.01％～20％ |
| Emulsifying agent | 3～30％ |
| Wetting dispersant | 5～15％ |
| Synergistic agent | 10～30％ |
| Stabilizing agent | 1～8％ |
| Solvent(s) | Make up for the allowance |
The preparation method comprises the following steps: adding the metered fosthiazate, fluopyram, a solvent and other auxiliary agents into a blending kettle, stirring to dissolve the fosthiazate, the solvent and the other auxiliary agents, adding an emulsifying agent, supplementing the rest with the residual solvent, uniformly stirring in the stirring kettle, and filtering to obtain the emulsifiable concentrate required by the invention.
15% fluopyram fosthiazate (1:14) emulsifiable concentrate preparation examples and comparative examples:
preparation example 1
Preparation example 2
Preparation example 3
Preparation example 4
Comparative example 1
Comparative example 2
Comparative example 3:
comparative example 4
Example 1
And (3) measuring main performance indexes:
the quality and physical and chemical properties of the preparation are detected by the following method:
table 1 preparation mainly refers to the basis for detecting performance indexes
TABLE 2 determination results of main performance indexes of 15% fluopyram fosthiazate emulsifiable concentrate
As is clear from the above table, the formulations of preparation examples 1 to 4 were superior to comparative examples 1 to 4 in all properties and acceptable in low temperature and heat storage stability. In addition, the degradation rate of the active ingredients in preparation examples 1-4 is obviously lower than that in comparative examples 1-4.
And (3) field efficacy test: cucumber root knot nematode control test by 15% fluopyram fosthiazate (1:14) emulsifiable concentrate
Example 2
Test target: cucumber root knot nematodes (Meloidogyne incognita);
test crops and varieties: cucumber (bonai No. 13);
test site: the water and fertilizer management of the test site is good in the Wuquan Zhenjiangcun of Yang Ling demonstration area of Shanxi province.
The test is based on: the test refers to GB/T19780.38-2000 pesticide field efficacy test criterion (1) nematicide for preventing and treating root nematode disease;
test agent: 15% of fosthiazate fluopyram suspension (preparation example 1, preparation example 3, comparison example 1, comparison example 2, comparison example 3 and comparison example 4), 20% of fosthiazate aqueous emulsion and 41.7% of fluopyram suspension.
The test method comprises the following steps: area per cell of 20m 2 The treatment is repeated for 4 times, and after the cucumber transplanting survival is carried out for one week, the preparation is added with water to irrigate roots and apply medicines to the cucumber according to the test design.
Test time and times: after cucumber transplanting field planting seedling-restoring (20 days of 8.2018), the preparation is applied once by adding water to perform hole application, and 200mL of the preparation is applied to each hole. During the test period, no nematicide was used in each cell, and the other drugs were the same.
The investigation method comprises the following steps: five points are taken from each district according to a diagonal sampling method during investigation after the cucumber root irrigation is carried out for 2 months (10 months and 20 days in 2018), 2 plants are investigated at each point, and the disease index and the prevention and treatment effect are calculated.
The disease classification method comprises the following steps:
level 0: the root system has no insect gall;
stage 1: the root system has a small amount of insect gall;
3 stages: 2/3 root systems are covered with small insect gall;
5 stages: the root system is covered with small insect gall and has secondary insect gall;
7 stages: the root system forms fibrous root clusters.
The drug effect calculation method comprises the following steps:
the results of the field efficacy test are shown in Table 3.
TABLE 3 test results of 15% fluopyram fosthiazate (1:14) emulsifiable concentrate for controlling cucumber root knot nematode
Example 3
Test target: cucumber root knot nematodes (Meloidogyne incognita);
test crops and varieties: cucumber (Xintaimi thorns);
test site: the soil is ginger black soil, the soil fertility is moderate, and the water and fertilizer management is consistent. No other diseases, weeds and pests occur in the test lands, and no other nematicides are used for preventing and controlling nematodes in the test lands.
The test is based on: the test refers to GB/T19780.38-2000 pesticide field efficacy test criterion (1) nematicide for preventing and treating root nematode disease;
test agent: 15% of fosthiazate fluopyram suspension (preparation example 1, preparation example 2, preparation example 3, comparison example 1, comparison example 2, comparison example 3 and comparison example 4), 20% of fosthiazate aqueous emulsion and 41.7% of fluopyram suspension.
And (3) test design: area per cell 15m 2 Repeating the treatment for 4 times, and after the cucumber is transplanted and the seedlings are slowly transplanted, root irrigation and pesticide application are carried out on the cucumber, wherein each plant of cucumber is filled with 200mL of pesticide liquid.
Test time and times: after cucumber transplanting field planting seedling-restoring (24 days of 7 months in 2019), the preparation is applied to the holes by adding water, and during the test period, no nematicide is used in each cell, and other medicines are the same.
Investigation time and investigation method: the test is to investigate the control effect once in the cucumber fruit harvesting period (10 months and 8 days in 2019), investigate all cucumbers in each district, and calculate the disease index and the control effect.
The disease classification method comprises the following steps:
level 0: the root system has no insect gall;
stage 1: the root system has a small amount of insect gall;
3 stages: 2/3 root systems are covered with small insect gall;
5 stages: the root system is covered with small insect gall and has secondary insect gall;
7 stages: the root system forms fibrous root clusters.
The drug effect calculation method comprises the following steps:
the test results are shown in Table 4.
TABLE 4 test results of 15% fluopyram fosthiazate (1:14) emulsifiable concentrate for controlling cucumber root knot nematode
The field test results show that the 15% fosthiazate fluopyram emulsifiable concentrate has good control effect on cucumber root knot nematodes.
Example 4 determination of cucumber root Activity by different agent treatments
Test site: the group bioassay center was performed in a solar greenhouse. Planting cucumber by potting method, transplanting the cucumber seedlings with consistent size and 3 leaf period cultivated in advance into pot after soil passes through 20 mesh sieve and is potted, and watering periodically and quantitatively.
Crops and varieties: cucumber (Xintaimi thorns).
The application method comprises the following steps: according to the recommended dosage of 20% fosthiazate aqueous emulsion of 2250-3000 g/hectare, the dosage of the active ingredients of 20% fosthiazate aqueous emulsion is 4500 g/hectare, and the dosage of the active ingredients of 20% fosthiazate aqueous emulsion is set as the dosage of the active ingredients of other control treatment groups (the dosage of the active ingredients of each treatment is shown in the table below). And calculating the dosage of each plant according to the surface area of the seedling pot after soil filling, and filling 200mL of liquid medicine into each plant of cucumber. Each treatment was repeated 30 times.
Test determination method: the activity of the cucumber root system is measured by using a TTC method, the cucumber root system is retrieved and cleaned 20d, 35d and 50d after the application, 0.5g of the cucumber root system is placed in a culture dish, 10mL of 0.4% of red tetrazolium and 10mL of phosphoric acid buffer solution (pH=7) are added, the temperature is kept away from light at 37 ℃ for 10h, and 10mL of 1mol/L sulfuric acid solution is taken out and added to terminate the reaction. Taking out root system, sucking to dry, placing in test tube, adding 10mL 95% ethanol, sealing the tube orifice, placing in dark place, leaching for 12h, pouring out leaching solution, and colorizing at 484nm wavelength. The root activity is expressed by TTC reduction amount. 10 cucumber root system activities were measured for each treatment, and the average value of the individual plants was obtained.
The test results are shown in Table 5:
table 5 determination of cucumber root system Activity by different agent treatments
When the dosage of the active ingredients of the fosthiazate is 4500 g/hectare, the 20% fosthiazate aqueous emulsion and the control example have a certain inhibition effect on the root system activity of the cucumber, wherein the inhibition effect of the 20% fosthiazate aqueous emulsion is most obvious, the preparation example 1 and the preparation example 3 have no inhibition effect on the root system activity of the cucumber, and the 15% fluopyram fosthiazate (1:14) emulsifiable concentrate provided by the invention has higher safety on target crops.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (10)
1. The emulsifiable concentrate containing fosthiazate and fluopyram and the preparation method thereof are characterized in that the emulsifiable concentrate consists of the following components in percentage by weight: 1 to 30 percent of fosthiazate, 0.01 to 20 percent of fluopyram, 3 to 30 percent of emulsifying agent, 5 to 15 percent of wetting dispersant, 10 to 25 percent of synergistic agent, 1 to 8 percent of stabilizer and 100 percent of solvent.
2. The emulsifiable concentrate according to claim 1, wherein the emulsifier is one or more selected from the group consisting of tristyrylphenol polyoxyethylene ether, dodecylbenzene sulfonate, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkylsuccinamide sulfonate, alkylphenol formaldehyde polyoxyethylene ether, phenethylphenylpropyl phenol polyoxyethylene polyoxypropylene ether and tween-80.
3. The emulsifiable concentrate according to claim 2, wherein said emulsifier is selected from one or more of tristyrylphenol polyoxyethylene ether, dodecylbenzene sulfonate, castor oil polyoxyethylene ether, alkylsuccinamide sulfonate, alkylphenol polyoxyethylene ether, and tween-80;
preferably, the emulsifier is a mixture of alkylphenol ethoxylates, ammonium dodecyl benzene sulfonate and alkyl succinamide sulfonate.
4. The emulsifiable concentrate of claim 1 wherein the wetting dispersant is a mixture of a poly (styrene-co-phenol-polyoxyethylene ether) phosphate and a fatty amine polyoxyethylene ether.
5. The emulsifiable concentrate as set forth in claim 4, characterized in that the mass ratio of said poly styrene phenol polyoxyethylene ether phosphate to fatty amine polyoxyethylene ether is (2-4): 1-3.
6. The emulsifiable concentrate of claim 5, wherein the mass ratio of the poly styrene phenol polyoxyethylene ether phosphate to the fatty amine polyoxyethylene ether is 3:2.
7. The emulsifiable concentrate of claim 1 wherein said synergist is a pinoresinol oil.
8. The emulsifiable concentrate according to claim 1, characterized in that the solvent is one or more selected from cyclohexanone, solvent oil, xylene, acetophenone or azamethylpyrrolidone;
preferably, the solvent is cyclohexanone or a mixture of nitrogen methyl pyrrolidone.
9. The emulsifiable concentrate according to claim 1, characterized in that said stabilizer is selected from any one of block polyether, epoxidized soybean oil or methyl ester oil;
preferably, the stabilizer is methyl ester oil.
10. The preparation method of the emulsifiable concentrate containing fosthiazate and fluopyram is characterized by comprising the following steps of: adding fosthiazate, fluopyram, wetting dispersant, synergist and stabilizer into a blending kettle, stirring to dissolve the fosthiazate, the wetting dispersant, the synergist and the stabilizer, adding the emulsifier, supplementing the rest with the rest solvent, uniformly stirring in the stirring kettle, and filtering to obtain the product.
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