CN117000324A - Pipetting element - Google Patents
Pipetting element Download PDFInfo
- Publication number
- CN117000324A CN117000324A CN202310794795.7A CN202310794795A CN117000324A CN 117000324 A CN117000324 A CN 117000324A CN 202310794795 A CN202310794795 A CN 202310794795A CN 117000324 A CN117000324 A CN 117000324A
- Authority
- CN
- China
- Prior art keywords
- pipetting
- section
- liquid
- element according
- pipetting element
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims abstract description 70
- 239000011324 bead Substances 0.000 claims abstract description 25
- 238000003860 storage Methods 0.000 claims abstract description 13
- 238000000926 separation method Methods 0.000 claims abstract description 10
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 238000001514 detection method Methods 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 239000002250 absorbent Substances 0.000 claims description 4
- 230000002745 absorbent Effects 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 230000008105 immune reaction Effects 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 7
- 239000004005 microsphere Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036046 immunoreaction Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
Abstract
The application relates to an experimental instrument, in particular to a liquid-moving element, which comprises a body and an absorption part arranged in the body, wherein the body is conical, the body sequentially comprises a connecting section, a liquid storage section and a liquid absorption section from the thick end to the thin end of the conical shape, the connecting section is used for being matched with the liquid-moving device, the absorption part is a magnetic absorption part, the liquid-moving element can simply and rapidly realize separation of magnetic beads and liquid, the cost is low, the operation is rapid and simple, the experimental efficiency is improved, the manufacturing cost of a machine can be reduced, and the labor cost can be reduced.
Description
Technical Field
The application relates to experimental instruments, in particular to a pipetting element.
Background
The liquid transfer device is a common tool for transferring liquid, is matched with a consumable liquid transfer suction head, is sleeved with the liquid transfer suction head when in use, discharges partial air in the liquid transfer suction head by operating the liquid transfer device, sucks the liquid in a container by using the atmospheric pressure, and releases the sucked liquid in the liquid transfer suction head by operating the liquid transfer device again after moving to a destination, so that liquid transfer is completed. The pipette tips of the prior art are typically of a simple conical housing construction, and more complex, have a filter element within the conical housing to prevent damage to the pipette and sample during removal of substances (e.g., bacteria, viruses, volatile, corrosive or viscous chemicals) that may contaminate the pipette. However, these two pipetting tips currently available are only capable of transferring liquid and cannot be used for more complicated operations.
In the prior art, if the magnetic beads in the liquid are to be separated from the liquid containing the magnetic beads, the operation process is to place a centrifuge tube of the liquid containing the magnetic beads on a magnetic frame, make the magnetic beads completely absorbed by the magnetic frame after magnetic attraction for a period of time, then carefully suck the supernatant by a pipettor, and the separation purpose is achieved after repeating the process for several times, or the magnetic rod and the magnetic rod sleeve are combined for use to achieve the separation purpose. The two methods are complex in operation and cannot separate the magnetic beads simply and rapidly.
Content of the application
In view of the above-mentioned drawbacks of the prior art, an object of the present application is to provide a pipetting element for solving the problems of the prior art.
To achieve the above and other related objects, the present application provides a pipetting element, which includes a body and an adsorbing member disposed in the body, wherein the body includes a connection section, a liquid storage section and a liquid sucking section that are sequentially communicated, the connection section is adapted to be matched with a pipettor, and the adsorbing member is a magnetic adsorbing member.
Preferably, the adsorption element is arranged in the liquid storage section or in the liquid suction section, or at the junction of the liquid storage section and the liquid suction section.
Preferably, the absorbing member is a column.
Preferably, the absorbing member is a magnet.
Preferably, the two poles of the magnet are parallel or perpendicular to the radial direction of the body.
Preferably, the absorption member is provided with a liquid through hole.
Preferably, the liquid through hole is parallel to the axial direction of the body (i.e., the extending direction of the body).
Preferably, the outer diameter of the absorbing member is the same as the inner diameter of the liquid storage section or the inner diameter of the liquid suction section, or the inner diameter of the junction of the liquid storage section and the liquid suction section.
Preferably, the absorbing member is further provided with a concave portion.
Preferably, the recess is a groove parallel to the axial direction of the body.
Preferably, a supporting piece is arranged in the body and is connected with the inner wall of the body.
Preferably, the support member is provided with a support table.
As described above, the pipetting element of the application has the following beneficial effects: the separation of magnetic beads and liquid can be simply and rapidly realized, the cost is low, the automation is convenient, and the experimental efficiency is improved. And can realize molecular detection, immunodetection, separation and detection of macromolecules or small molecules such as proteins and polypeptides according to different substances combined on the surfaces of the separated magnetic beads, i.e. can realize multiple applications.
Drawings
FIG. 1 is a schematic cross-sectional view of a pipetting element according to the application.
Fig. 2 shows a perspective view of a pipetting element according to the application.
Fig. 3 shows a front view of a pipetting element according to the application.
Fig. 4 shows one of the cross-sectional views of the pipetting element of the application.
Fig. 5 shows a partial enlarged view of the pipetting element of the application at the suction fitting.
Fig. 6 shows one of the top views (without the absorbent member) of the pipetting element of the application.
Fig. 7 shows one of the top views (including the adsorbing member) of the pipetting element of the application.
Fig. 8 shows one of a schematic top and side view of the absorbent member of the present application.
Description of element reference numerals
1. Body
11. Connecting section
12. Liquid storage section
13. Liquid suction section
2. Suction fitting
21. Liquid through hole
22. Recess portion
3. Support member
31. Supporting table
Detailed Description
Further advantages and effects of the present application will become apparent to those skilled in the art from the disclosure of the present application, which is described by the following specific examples.
Please refer to fig. 1 to 8. It should be understood that the structures, proportions, sizes, etc. shown in the drawings are for illustration purposes only and should not be construed as limiting the application to the extent that it can be practiced, since modifications, changes in the proportions, or otherwise, used in the practice of the application, are not intended to be critical to the essential characteristics of the application, but are otherwise, required to achieve the objective and effect taught by the application. Also, the terms such as "upper," "lower," "left," "right," "middle," and "a" and the like recited in the present specification are merely for descriptive purposes and are not intended to limit the scope of the application, but are intended to provide relative positional changes or modifications without materially altering the technical context in which the application may be practiced.
As shown in fig. 1, the application provides a pipetting element, which comprises a body 1 and an adsorption element 2 arranged in the body 1, wherein the body 1 is conical, the body 1 comprises a connecting section 11, a liquid storage section 12 and a liquid suction section 13 which are communicated in sequence, the connecting section 11 is used for adapting to a pipettor, and the adsorption element 2 is a magnetic adsorption element.
The body 1 is in a cone shape, the connecting section 11 is arranged at the thick end of the cone shape, and the liquid suction section is arranged at the thin end of the cone shape.
In certain embodiments of the application, the pipetting element is a pipetting tip.
The body 1 is a conical structure with a cavity. In some embodiments of the application, the body 1 is conical.
The inner diameter of the connecting section 11 is adapted to the pipetting element mounting of the pipette. The pipette may be any device that can push air in the pipetting element after the pipetting element is engaged, such as a pipette gun. The end part of the liquid suction section 13 is provided with a liquid hole. The liquid hole is used for sucking liquid or discharging liquid in the liquid transferring element.
In some embodiments of the application, a filter element may also be provided in the body 1. In a preferred embodiment, the filter cartridge is provided in the connection section 11 and/or the reservoir section 12.
The adsorption piece 2 is arranged in the liquid storage section 12 or in the liquid suction section 13, or at the junction of the liquid storage section 12 and the liquid suction section 13.
The number of the adsorbing members 2 is not particularly limited, and is, for example, one, two, three or more.
The adsorbing member 2 is a column.
In the embodiment of the present application shown in fig. 1 to 7, the adsorbing member 2 is a cylinder.
In some embodiments of the application, the adsorbent 2 is a magnet.
The two poles of the magnet are parallel or perpendicular to the radial direction of the body 1.
In some preferred embodiments of the present application, the line connecting the two poles of the magnet is perpendicular to the extending direction of the body 1 (when the body 1 is conical, the extending direction of the body 1 is axial, i.e. the line connecting the two poles of the magnet is parallel to the radial direction of the body 1). The advantage of this design is the large surface area for adsorption and most importantly the absence of clogging of the pipetting element.
In the preferred embodiment shown in fig. 1 to 7, a support 3 is provided in the body 1, and the support 3 is preferably fixedly connected to the inner wall of the body 1. The support 3 is used for fixing and supporting the suction member 2. The direction of the support 3 is parallel to the axial direction of the body 1.
As shown in fig. 6, the support 3 is provided with a support table 31. Specifically, a supporting table 31 is disposed on the opposite side of the supporting member 3 connected to the body 1.
The support 3 is provided in plurality. The adsorbing members 2 are erected on support tables 31 on the plurality of supporting members 3. The number of the supporting members 3 is, for example, 2 to 4. In the embodiment of the application shown in fig. 1 to 7, 3 support elements 3 are provided.
The combination of the support 3 and the cylindrical suction member may simplify the production process of the pipetting element.
In the embodiment of the present application shown in fig. 8, the suction member 2 is provided with a liquid passage hole 21. The liquid through hole 21 is used for passing liquid.
The liquid passage hole 21 is parallel to the axial direction of the body 1. The shape of the liquid passage hole 21 is not particularly limited, and may be, for example, circular or square.
The number of the liquid passing holes 21 is not particularly limited, and is, for example, one (as shown in fig. 8), two, three, four, five or more.
The diameter of the liquid through hole 21 is 0.3-0.6 mm. For example, 0.3 to 0.4mm, 0.4 to 0.5mm, and 0.5 to 0.6mm.
In the embodiment of the present application shown in fig. 8, the outer diameter of the adsorbing member 2 is the same as the inner diameter of the liquid storage section 12 or the inner diameter of the liquid suction section 13, or the inner diameter at the junction of the liquid storage section 12 and the liquid suction section 13. The same inside diameter allows the absorbent member 2 to be secured in a specific location within the body 1, such as at the reservoir section 12 or the wicking section 13, or at the interface of the reservoir section 12 and the wicking section 13, such that it cannot move within the body 1.
In the embodiment shown in fig. 8, the adsorbing member 2 is further provided with a recess 22.
In some embodiments of the application, the recess 22 is a groove parallel to the axial direction of the body 1, i.e. in the same direction as the direction of the fluid flow. The recess 22 is designed so as not to block the pipetting element in use.
The dimensions, other features, etc. of the pipetting elements of the application may be designed according to the dimensions of pipetting tips conventional in the art, the application being not particularly limited.
The format of the pipetting element of the application may be 10. Mu.L, 20. Mu.L, 100. Mu.L, 200. Mu.L, 300. Mu.L, 1000. Mu.L, 1250. Mu.L, 5mL or 10mL.
In certain embodiments of the application, the pipetting elements may be polypropylene material free of DNase, RNase, pyrogen, human DNA and RNA.
In certain embodiments of the application, the pipetting element may or may not be sterilized.
The application also provides the application of the pipetting element in magnetic bead separation or in the preparation of nucleic acid extraction or detection products, products for immune reaction or products for removing impurities.
The nucleic acid detection product or the immunoreaction product may be determined according to the surface properties of the magnetic beads, for example, when the surface of the magnetic beads is silica, the nucleic acid detection product or the immunoreaction product is generally used for nucleic acid extraction or nucleic acid detection; for example, when the surface of the magnetic beads is coupled with a protein, an antibody or an affinity group, the magnetic beads can be used for antigen detection or used for separation, concentration and purification of the protein.
The pipetting element of the application can be used to carry magnetic beads to participate in reactions. That is, after the magnetic beads are adsorbed on the adsorbing member 2, the body 1 of the pipetting element can be used as a reaction vessel to react the reagent with the substances on the magnetic beads by re-sucking or discharging other reagents.
The application also provides a magnetic bead separation method, which comprises the steps of mounting the pipetting element on a pipetting device, and repeatedly sucking and discharging the liquid containing the magnetic beads by using the pipetting device to separate the magnetic beads from the liquid.
The application method of the pipetting element of the application is as follows:
the liquid-transferring element is arranged on a liquid-transferring device, the liquid containing the magnetic microsphere is sucked, the sucked liquid is slowly discharged, the magnetic microsphere can be adsorbed on the adsorbing piece 2 in the liquid-transferring element, and the sucking and the discharging are repeated until the liquid is clear, and the magnetic microsphere is completely adsorbed on the adsorbing piece 2. The pipetting elements adsorbing the magnetic microspheres can further perform further treatment or reaction on the adsorbed magnetic microspheres by sucking and releasing other liquid according to different substances combined on the surfaces of the magnetic microspheres based on the purposes of detection, washing and the like, and the pipetting elements at the moment also serve as reaction containers, so that the treatment process of the magnetic beads is simplified very.
In summary, the present application effectively overcomes the disadvantages of the prior art and has high industrial utility value.
The above embodiments are merely illustrative of the principles of the present application and its effectiveness, and are not intended to limit the application. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the application. Accordingly, it is intended that all equivalent modifications and variations of the application be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.
Claims (14)
1. The pipetting element is characterized by comprising a body (1) and an adsorption piece (2) arranged in the body (1), wherein the body (1) comprises a connecting section (11), a liquid storage section (12) and a liquid suction section (13) which are communicated sequentially, the connecting section (11) is used for being matched with a pipetting device, and the adsorption piece (2) is a magnetic adsorption piece.
2. Pipetting element according to claim 1, wherein the body (1) is conical, the connecting section (11) being provided at the thick end of the cone and the pipetting section being provided at the thin end of the cone.
3. Pipetting element according to claim 1, wherein the body (1) is a conical structure with a cavity;
and/or the end part of the liquid suction section (13) is provided with a liquid hole.
4. Pipetting element according to claim 1, wherein the adsorption element (2) is arranged in the reservoir section (12) or in the pipetting section (13) or at the junction of the reservoir section (12) and the pipetting section (13).
5. Pipetting element according to claim 1, wherein the number of suction elements (2) is one or more and/or wherein the suction elements (2) are cylinders.
6. Pipetting element according to claim 1, wherein the suction element (2) is a magnet.
7. Pipetting element according to claim 6, wherein the two poles of the magnet are parallel or perpendicular to the extension direction of the body (1).
8. Pipetting element according to claim 1, wherein the suction element (2) is provided with a through-going hole (21).
9. Pipetting element according to claim 8, wherein the through-openings (21) are parallel to the extension direction of the body (1) and/or the number of through-openings (21) is 1-6.
10. Pipetting element according to claim 8, wherein the outer diameter of the adsorbing member (2) is at its maximum with the inner diameter of the reservoir section (12) or the inner diameter of the pipetting section (13), or the inner diameter of the junction of the reservoir section (12) and the pipetting section (13) is the same; and/or the adsorption piece (2) is also provided with a concave part (22), and the concave part (22) is a groove parallel to the extending direction of the body (1).
11. Pipetting element according to claim 1, wherein a support (3) is arranged in the body (1), one side of the support (3) being connected to the inner wall of the body (1) and the other side being provided with a support table (31) for mounting the absorbent member (2).
12. Pipetting element according to claim 11, wherein the support (3) is provided with a plurality.
13. Use of a pipetting element according to any one of claims 1 to 12 for magnetic bead separation or for the preparation of a nucleic acid extraction or detection product, a product for an immunological reaction or a product for the removal of impurities or for carrying magnetic beads for reactions.
14. A magnetic bead separation method, comprising mounting the pipetting element according to any one of claims 1 to 12 to a pipette, and repeatedly sucking and discharging a liquid containing magnetic beads by the pipette to separate the magnetic beads from the liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310794795.7A CN117000324A (en) | 2023-06-30 | 2023-06-30 | Pipetting element |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310794795.7A CN117000324A (en) | 2023-06-30 | 2023-06-30 | Pipetting element |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117000324A true CN117000324A (en) | 2023-11-07 |
Family
ID=88570159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310794795.7A Pending CN117000324A (en) | 2023-06-30 | 2023-06-30 | Pipetting element |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117000324A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012103214A2 (en) * | 2011-01-26 | 2012-08-02 | Molecular Bioproducts, Inc. | Magnetic pipette tip |
| CN113438973A (en) * | 2018-12-20 | 2021-09-24 | 帝肯贸易股份公司 | Suction head cup body |
| CN217549846U (en) * | 2022-04-19 | 2022-10-11 | 上海思路迪生物医学科技有限公司 | Pipettor and pipettor module |
| CN217910501U (en) * | 2022-08-15 | 2022-11-29 | 安图实验仪器(郑州)有限公司 | Disposable pipette tip |
-
2023
- 2023-06-30 CN CN202310794795.7A patent/CN117000324A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012103214A2 (en) * | 2011-01-26 | 2012-08-02 | Molecular Bioproducts, Inc. | Magnetic pipette tip |
| CN113438973A (en) * | 2018-12-20 | 2021-09-24 | 帝肯贸易股份公司 | Suction head cup body |
| CN217549846U (en) * | 2022-04-19 | 2022-10-11 | 上海思路迪生物医学科技有限公司 | Pipettor and pipettor module |
| CN217910501U (en) * | 2022-08-15 | 2022-11-29 | 安图实验仪器(郑州)有限公司 | Disposable pipette tip |
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