CN116983552A - Short-distance therapeutic apparatus capable of carrying miniature source - Google Patents
Short-distance therapeutic apparatus capable of carrying miniature source Download PDFInfo
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- CN116983552A CN116983552A CN202210443300.1A CN202210443300A CN116983552A CN 116983552 A CN116983552 A CN 116983552A CN 202210443300 A CN202210443300 A CN 202210443300A CN 116983552 A CN116983552 A CN 116983552A
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- miniature
- source
- inner support
- brachytherapy
- flexible inner
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- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 38
- 238000002725 brachytherapy Methods 0.000 claims abstract description 28
- 201000010099 disease Diseases 0.000 claims abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
- 230000005855 radiation Effects 0.000 claims description 13
- 239000000956 alloy Substances 0.000 claims description 4
- 230000035515 penetration Effects 0.000 claims description 4
- 231100000987 absorbed dose Toxicity 0.000 claims description 3
- 229910045601 alloy Inorganic materials 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims description 2
- 239000007943 implant Substances 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 abstract description 10
- 239000012528 membrane Substances 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 description 12
- 206010006187 Breast cancer Diseases 0.000 description 10
- 208000026310 Breast neoplasm Diseases 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 239000012830 cancer therapeutic Substances 0.000 description 6
- 208000001969 capillary hemangioma Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 229920002379 silicone rubber Polymers 0.000 description 3
- 229910000990 Ni alloy Inorganic materials 0.000 description 2
- 201000005969 Uveal melanoma Diseases 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- MOWMLACGTDMJRV-UHFFFAOYSA-N nickel tungsten Chemical compound [Ni].[W] MOWMLACGTDMJRV-UHFFFAOYSA-N 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 208000002260 Keloid Diseases 0.000 description 1
- 206010023330 Keloid scar Diseases 0.000 description 1
- 208000004059 Male Breast Neoplasms Diseases 0.000 description 1
- 206010027145 Melanocytic naevus Diseases 0.000 description 1
- 208000007256 Nevus Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000005389 breast carcinoma in situ Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000005264 electron capture Effects 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 210000001117 keloid Anatomy 0.000 description 1
- 201000011486 lichen planus Diseases 0.000 description 1
- 201000003175 male breast cancer Diseases 0.000 description 1
- 208000010907 male breast carcinoma Diseases 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/02—Radiation therapy using microwaves
- A61N5/04—Radiators for near-field treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/02—Radiation therapy using microwaves
- A61N5/04—Radiators for near-field treatment
- A61N5/045—Radiators for near-field treatment specially adapted for treatment inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1016—Gynaecological radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1017—Treatment of the eye, e.g. for "macular degeneration"
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
- A61N5/1029—Radioactive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1024—Seeds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
Abstract
The invention discloses a 'brachytherapy device capable of carrying a miniature radioactive source', which is called a 'brachytherapy device capable of carrying a miniature source'. The main components of the therapeutic device are a flexible inner support and a matched shielding shell, wherein the flexible inner support can carry different nuclides and different numbers of miniature radioactive sources, such as a device capable of emitting low-energy photons 125 I、 103 Pd、 169 Miniature radioactive source made of Yb and other nuclides, seed source. The outer side of the flexible inner support carrying the miniature radioactive source is tightly attached to the inner side of the shielding shell, and the inner side (non-shielding side) of the flexible inner support can form an irradiation window for intensively releasing low-energy photons so as to implement close-range treatment for some difficult and common diseases, including surface application treatment or intracavity, tube and membrane treatment. Such brachytherapy devices with miniature sourcesProvides a safe, effective, accurate and economical brachytherapy means for patients.
Description
Technical Field
The invention discloses a novel medical apparatus, in particular to a plurality of brachytherapy apparatuses capable of carrying miniature radioactive sources. The surface application treatment or the intracavity, the intraductal and the intramembrane treatment are carried out by utilizing the low-energy photons emitted by the carried miniature radioactive source, and the surface application treatment or the intracavity, the intraductal and the intramembrane treatment are called as a 'brachytherapy device capable of carrying the miniature radioactive source', and the short-term 'brachytherapy device capable of carrying the miniature radioactive source'.
Background
Surgery, chemotherapy and radiation therapy have become three major means of treating tumors today. In the case of radiotherapy, there are two broad categories, sealed radiation source therapy and unsealed radiation source therapy. Sealed radiation source therapies (radiation-containing devices) include both tele-therapy (abbreviated as "tele-therapy") and brachytherapy (abbreviated as "brachytherapy").
Brachytherapy may deliver radiation therapy to a patient's focal site within close range relative to brachytherapy. It is apparent that brachytherapy has the advantage that the illumination distance is very short, allowing illumination proximate to the tissue surface, even into the tissue. Therefore, gamma rays with lower energy and better penetrability can be utilized; beta rays with larger ionization density and smaller penetrability; and alpha rays having a large ionization density and a small penetration capacity. Compared with high-energy gamma rays, the gamma rays have the advantages of being safer, more reliable, more accurate and the like.
The patent aims to develop a safe, effective, accurate and economical short-distance medical instrument. It is assumed that the radiation is shielded by a flexible inner holder on which a plurality of micro radiation sources can be mounted, and a metal or alloy housing is closely attached to the outer side of the flexible inner holder, so that a window for concentrated radiation emission can be formed on the other side, i.e., the inner side, and short-distance irradiation can be performed on the focus part of the patient.
Such medical devices are called "brachytherapy devices capable of carrying a miniature radiation source", and are called "brachytherapy devices capable of carrying a miniature radiation source". The main components of the device are a flexible inner support and a shielding shell, wherein the miniature radioactive source carried by the flexible inner support selects nuclides capable of releasing low-energy photons: 125 I， 103 Pd、 169 miniature sources made of Yb, known as seed sources (seeds sources), are suitable. Clinical studies show that the near-distance therapeutic apparatus capable of carrying miniature sources can apply surface application therapy or intracavity therapy to some difficult and common diseases,The curative effect of the in-tube and in-membrane treatment is exact, and the use is safe.
Disclosure of Invention
The invention relates to a near-distance therapeutic apparatus capable of carrying micro sources, which is characterized in that the main components of the near-distance therapeutic apparatus are a flexible inner support and a shielding shell, wherein the flexible inner support can carry different nuclides and different numbers of micro sources, when the inner side of the shielding shell is combined with the outer side of the flexible inner support carrying the micro sources, the inner side (non-shielding side) of the flexible inner support forms a ray concentrated emission area (namely an irradiation window), and safe and effective irradiation treatment can be implemented on focus parts of patients.
The invention relates to a near therapeutic device capable of carrying micro source, which is characterized in that the micro source selects to emit low-energy gamma rays 125 I、 103 Pd、 169 Seed source made of Yb and other nuclides. The common point is that the decay forms are Electron Capture (EC), the nuclide half-life is not short and long (60 d, 17d and 32d respectively), the radiation energy is low (< 100 KeV), the method belongs to the category of low-energy gamma rays, and the penetration capability in human tissues is very suitable for brachytherapy.
The near-distance therapeutic apparatus capable of carrying the miniature source is characterized in that the flexible inner support is made of medical polymer materials with moderate flexibility, has good biocompatibility, can resist radiation and can meet clinical requirements. In addition, the flexible inner support can reasonably and orderly arrange a plurality of grooves by means of computer 3D design software and experimental test means so as to carry different numbers of seed sources. The flexible inner support not only has the function of supporting, fixing and sealing the seed source, but also can meet the uniformity of the spatial dose distribution required by irradiation treatment.
The invention relates to a near-distance therapeutic apparatus capable of carrying a miniature source, which is characterized in that a shielding shell of the therapeutic apparatus is made of metal or alloy with good biocompatibility and good radiation shielding effect. Depending on the useDifferent, the periphery of the shielding shell can be free of earrings (holes are punched in the middle of the flange), and can also extend out of the shielding shell for 2-6 timesEar rings for fixing therapeutic equipment; the perimeter of the shield can may be free of a grommet or with a grommet.
The near-distance therapeutic apparatus capable of carrying the miniature source is characterized in that the flexible inner support and the matched shielding shell can be closely attached, so that the phenomenon that the seed source falls off during the operation process and the treatment period is further avoided, and the safety is ensured.
The miniature source-mountable brachytherapy device of the present invention is characterized in that the total radioactivity of the device is controlled in the range of 370MBq-1480MBq (10 mCi-40 mCi) to obtain proper irradiation time and optimal therapeutic effect.
The invention relates to a near-distance therapeutic device capable of carrying micro sources, which is characterized in that a shielding shell and a flexible inner support of the therapeutic device can be made into three-dimensional shapes according to the characteristics of different diseases, wherein the three-dimensional shapes comprise regular shapes such as regular cubes, long cubes, cylinders, circular rings, ellipsoids, spherical crowns, dishes and the like or other irregular shapes.
The invention relates to a near-distance therapeutic apparatus capable of carrying a miniature source, which is characterized in that the near-distance therapeutic apparatus can be designed into flexible inner brackets with different models and specifications and shielding shells matched with the flexible inner brackets aiming at focus positions and 3D sizes of the same diseases.
The invention relates to a miniature source-mountable brachytherapy device which is characterized in that the device is not a permanent implantation device, and is only temporarily fixed when the treatment is implemented, and can be removed once the expected absorbed dose is reached.
Drawings
FIG. 1 is a schematic diagram of a breast cancer therapeutic apparatus that can be equipped with a miniature source. In the figure, 1 is a flexible inner support, 2 is a cylindrical shielding shell, and 3 is a seed source carried by the therapeutic device.
Fig. 2 is a schematic diagram of an intraocular tumor therapeutic apparatus that can be equipped with a miniature source. In the figure, 1 is a flexible inner support, 2 is a shielding shell with a spherical crown-shaped top part and a circular ring shape, and 3 is a seed source carried by the therapeutic apparatus.
Fig. 3 is a schematic diagram of a capillary hemangio therapeutic device that can carry a miniature source. In the figure, 1 is a flexible inner support, 2 is a cylindrical shielding shell, and 3 is a seed source carried by the therapeutic device.
Detailed Description
Embodiment 1: breast cancer therapeutic device capable of carrying miniature source
Figure 1 shows a breast cancer therapeutic device that can be equipped with a miniature source. As can be seen, the shape of the device is cylindrical (flat bottom). The main components are a flexible inner support 1 and a cylindrical shielding shell 2. The shielding shell is made of tungsten-nickel alloy or Ta, and the flexible inner support is made of medical silicon rubber. The hospital will order prior to treatment 125 I seed source 3 is embedded into the concave groove of the flexible inner support, then is arranged in the cylindrical shielding shell and is tightly attached, thus the breast cancer therapeutic device is assembled.
The use of 125 The size of the sealed seed source is phi 0.8mm multiplied by 4.5mm multiplied by 0.05mm, the radioactivity requirement reaches 0.9-1.0 mCi/grain, a titanium alloy material is used as an envelope, and reliable welding sealing is required to be implemented at the two ends so as to ensure that the seed source does not leak. In addition, the source surface is required to be free of radioactive contamination.
The dimensions of the flexible inner support and the shielding shell can be customized according to the tumor size. The diameter of the shielding shell is 23mm, and the height of the cylinder body is less than 3mm; the flexible inner support is cylindrical and can carry 24 seed sources. The breast cancer therapeutic apparatus is prepared by pressing the two components, adopts a surface application mode during treatment, and irradiates breast cancer from outside through skin 125 The penetration depth of the seed source in human tissue can reach 17-20 mm).
The breast cancer therapeutic apparatus capable of carrying micro source belongs to a new therapy for protecting breast and removing cancer. Is suitable for treating localized breast cancer: single-shot breast cancer, superficial breast cancer, in-situ breast cancer, male breast cancer patients and the like.
Embodiment 2: intraocular tumor therapeutic apparatus capable of carrying miniature source
Fig. 2 shows an intraocular tumor therapeutic device that can carry a miniature source. As can be seen, the shape of the therapeutic device is a combination of spherical crown shape and circular ring shape. The main components are a flexible inner support 1 and a shielding shell 2 with a spherical crown top connected with a circular ring shape. The shielding shell is made of Au or Ta, and the flexible inner support is made of medical silicon rubber. The hospital will order before surgeryA kind of electronic device 125 The seed source 3 is embedded in the concave groove of the flexible inner support, then is arranged in the shielding shell and is tightly attached, thus the intraocular tumor therapeutic device can be assembled.
The use of 125 I sealed seed source size as in embodiment 1, radioactivity requirement: 0.8mCi to 0.9mCi per grain. The flexible inner support and the shielding shell can be determined according to the size of the tumor in the eye. For medium-sized tumors, the flexible inner support commonly used can be embedded into 20 grains 125 I seed source, a matched shielding shell with the diameter of 18 mm.
In addition, the periphery of the shielding shell is provided with 2 flanges with angles of 90 degrees relative to each other and an opening in the middle, which are called as 'earrings', so that the intraocular tumor therapeutic device is tied and fixed on the sclera of the eye by using sutures during operation. The device is not "permanently" implanted, but is "temporarily" fixed (irradiation for days to 4 weeks, etc.), and is removed once the desired absorbed dose is reached.
The intraocular tumor therapeutic apparatus capable of carrying the miniature source can be used for treating adult uveal melanoma and infant retinoblastoma. Clinical studies show that the therapeutic device is most suitable for treating the uveal melanoma with the basal diameter less than 16mm and the height of 2.5-10 mm.
Embodiment 3: capillary hemangioma therapeutic device capable of carrying miniature source
Figure 3 shows a capillary hemangio therapeutic device that can carry a miniature source. As can be seen, the shape of the therapeutic device is cylindrical (it may also be designed as a right cube). The main components are a flexible inner support 1 and a shielding shell 2. The flexible inner support is made of medical silicon rubber, and the shielding shell is made of tungsten-nickel alloy or Ta. The hospital will order prior to treatment 125 The seed source 3 is embedded into the concave groove of the flexible inner support, and the flexible inner support is tightly attached to the shielding shell, thus the capillary hemangioma therapeutic device is assembled.
The use of 125 I sealed seed Source size was the same as in embodiment 1. Radioactivity required > 1.0 mCi/grain. The flexible inner support and the shielding shell can be customized according to the tumor size. The diameter of the common shielding shell is 21mm (the diameter of the active area is 20 mm), and the flexible inner support can be embedded20 granules of 125 I seed source. The total height of the therapeutic device is 5mm, and the medical adhesive dressing is used for fixing the therapeutic device on the periphery of capillary hemangioma during treatment, so that the surface application irradiation can be implemented.
The capillary hemangioma therapeutic device capable of carrying the miniature source can also treat skin diseases such as nevus ruber, lichen planus, keloid and the like.
Claims (10)
1. The invention discloses a near-distance therapeutic apparatus capable of carrying miniature sources, which is characterized in that main components of the near-distance therapeutic apparatus are a flexible inner support and a shielding shell, the flexible inner support can carry different nuclides and different numbers of miniature sources, the flexible inner support carrying the miniature sources is attached to the shielding shell, and an irradiation window can be formed on the inner side (non-shielding side) of the flexible inner support, so that safe and effective accurate treatment is implemented.
2. The miniature source-mountable brachytherapy machine of claim 1, wherein the flexible inner support of the machine is made of a moderately flexible medical polymer material.
3. The miniature source-mountable brachytherapy apparatus of claim 1, wherein the shielding housing of the apparatus is made of a biocompatible metal or alloy with good radiation shielding effect.
4. The miniature source-mountable brachytherapy device of claim 1, wherein the miniature source is selected to have a short half-life, low gamma energy, and good penetration into human tissue 125 I、 103 Pd or Pd 169 A sealed seed source made of Yb and other nuclides.
5. The miniature source-mountable brachytherapy device of claims 1 and 4, wherein the total radioactivity after mounting the miniature source is between 370MBq-1480MBq (10 mCi-40 mCi).
6. The miniature source-mountable brachytherapy apparatus of claims 1 and 2, wherein said flexible inner support is designed with a plurality of grooves arranged in order to mount a seed source by means of computer 3D design software and experimental testing means, so as to satisfy uniformity of spatial dose distribution required for brachytherapy.
7. A miniature source-mountable brachytherapy device according to claims 1 and 3, wherein the edges of the shield housing may be devoid of earrings or extend 2-6 earrings; either without a grommet or with a grommet.
8. The miniature source-mountable brachytherapy device of claims 1, 2, 3 and 4, wherein the flexible inner support and shielding housing of the brachytherapy device can be formed into desired three-dimensional shapes including regular or other irregular shapes such as regular cubes, long cubes, cylinders, rings, ellipsoids, crowns, dishes, etc. according to the characteristics of different diseases.
9. The miniature source-mountable brachytherapy device of claims 1, 2, 3, 4 and 6, wherein different models and sizes of flexible receptacles and matched shielding shells can be selected according to lesion location, 3D size and edge condition of the same disease.
10. The miniature source-mountable brachytherapy device of claim 1, wherein the device is not a "permanent" implant device, and wherein the treatment is performed with only a "temporary" fixation, and is removed once the desired absorbed dose has been reached.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210443300.1A CN116983552A (en) | 2022-04-26 | 2022-04-26 | Short-distance therapeutic apparatus capable of carrying miniature source |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210443300.1A CN116983552A (en) | 2022-04-26 | 2022-04-26 | Short-distance therapeutic apparatus capable of carrying miniature source |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116983552A true CN116983552A (en) | 2023-11-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210443300.1A Pending CN116983552A (en) | 2022-04-26 | 2022-04-26 | Short-distance therapeutic apparatus capable of carrying miniature source |
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| Country | Link |
|---|---|
| CN (1) | CN116983552A (en) |
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- 2022-04-26 CN CN202210443300.1A patent/CN116983552A/en active Pending
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