CN1169435A - Compound-silver glycyrrhetate preparation method and use thereof - Google Patents
Compound-silver glycyrrhetate preparation method and use thereof Download PDFInfo
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- CN1169435A CN1169435A CN 96108733 CN96108733A CN1169435A CN 1169435 A CN1169435 A CN 1169435A CN 96108733 CN96108733 CN 96108733 CN 96108733 A CN96108733 A CN 96108733A CN 1169435 A CN1169435 A CN 1169435A
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Abstract
The present invention relates to a new compound silver glycyrrhizinate. Its molecular formula is C42 H60 O16 Ag2. (1-5) H2O. Said invented product is made up by using glycyrrhizic acid c glycyrhizinate) and AgNO3 and making them react. Said compound can be used for preparing antimicrobial and antiviral medicine for external use.
Description
The present invention relates to a kind of new compound Potenlini silver, and the preparation of this compound and pharmaceutical usage, pharmacy field belonged to.
Potenlini silver, fraction formula C42H60O16Ag2 (1-5) H2O.
The germicidal action of silver be already known to the mankind also in addition utilization, the 19th-century Silver Nitrate just is used to treat illness in eye and wound, the appearance of sixties Sulfadiazine Silver (AgSD) makes the application of silver compound obtain new breakthrough, a large amount of documents and materials reports, silver ions has the effect of following several aspects: 1) have the effect of killing Pseudomonas aeruginosa, golden Portugal bacterium, intestinal bacteria, Bacillus subtilus, be used to treat burn, acute and chronic suppurates, the prevention gonococcus causes infection etc.; 2) can kill white coccus, yellow black-koji mould, the mould white bar of light and belong to fungi, be used to treat diseases such as trichomonas vaginitis; 3) can kill herpes simplex and varicella zoster virus, hepatitis virus and treponema pallidum, treatment is because the relative disease that these virus and microorganism cause.Studies show that in recent years, AgSD has AIDS resisting HTV (HIV (human immunodeficiency virus)), the effect of LAV (lymphoglandula sick body association virus) and HILV (human body cell leukosis virus), tentatively attempt preventing the AIDS cross infection with AgSD, but silver compound that is used for the treatment of at present such as AgNO3 are used for when clinical, generate insoluble AgCl because the chlorion in AgNO3 and the body fluid reacts, cause body surface Na
+, K
+, and Cl
-Imbalance.The disadvantage of AgSD is can not use the sulfonamides allergy sufferers, and this medicine life-time service can develop immunity to drugs.
The great mass of data report, Potenlini not only has anti-inflammatory, detoxifcation, anticancer effect, and tangible anti-chronic hepatitis, varicella arranged, the effect of varicella zoster virus and Candida albicans, noticeable especially is both domestic and externally to studies show that in a large number, glycyrrhizin and its esters have the effect that suppresses the HIV-1 virus replication, to because HIV infects the immune function depression cause and the haemophiliac of liver function imbalance, use a large amount of glycyrrhizins can prevent that it from developing into AIDS.
Compound Potenlini silver of the present invention is to be made by commercially available Potenlini (salt) and Silver Nitrate reaction, it not only possesses the antibiosis and antiviral functions of Potenlini and silver ions, and, therefore, can not produce the caused anaphylaxis of Sulphadiazine Sodium medicine because it does not conform to the Sulphadiazine Sodium group is arranged.Therefore the alternative or partly alternative AgSD of compound of the present invention is applied to treat owing to bacterium, the caused disease of virus infection and AIDS resisting virus and treats AIDS-related complex.
The preparation method of Potenlini silver of the present invention is as follows:
Get a certain amount of Potenlini (salt) with 1: 1-1: 20 ratios add ethanol (20-80%) solution, under 25-80 ℃ of temperature, stir, make its dissolving, the AgNO3 solution (being mixed with 0.05-1M concentration) that slowly adds stoichiometric quantity then with water, lucifuge 25-60 ℃ was reacted 3-8 hour down, ageing 8-24 hour, with frozen water or absolute ethanol washing, drying obtained product Potenlini silver under 20-80 ℃ of temperature.
Compound Potenlini of the present invention silver with the sucrose solution of 5-50% and polyvalent alcohol by 1: the solvent mixing of the mixed of 0.1-1 (volume ratio) makes the suspension of content 1-10% or 0.5% solution, and is promptly pharmaceutically acceptable, directly is coated on the affected part.
With the AgNO3 of present use, the AgSD medicine is compared, and Potenlini silver has the antibiotic of wide spectrum, antiviral activity, antibacterial effect is similar to the AgSD of widespread use clinically, but has the advantages that to be better than AgSD, do not have the anaphylaxis of AgSD to human body, silver content is low, but medicinal effect is good.
Embodiment 1:
Monoammonium glycyrrhizinate (C42H61O16NH4.5H2O) 5 grams place the 100ml beaker, add 50% ethanolic soln 60ml, be heated to 60 ℃, fully stir and make dissolving, get 1 gram AgNO3, after the 10ml water dissolution, slowly add, white precipitate to be occurred stops heating, and lucifuge stirred 6 hours, leave standstill, filter frozen water washing, 60 ℃ of dryings, get white products C42H60O16Ag25H2O, productive rate 47%, results of elemental analyses is: Ag18.82 (19.16), C44.72 (44.70), in the H6.49 (6.22), bracket is calculated value.
Embodiment 2:
Extracting liquorice acid potassium (C42H61O16K.3H2O) 100 restrains in the 500ml beaker, adds 30% ethanolic soln 300ml, is heated to 50 ℃, stirring and dissolving is got 5 gram AgNO3 and is dissolved in the 40ml water, slowly adds then, stirred 4 hours 40 ℃ of following lucifuges, ageing 15 hours is filtered, absolute ethanol washing, dry under 40 ℃ of temperature, get product, productive rate 62%, results of elemental analyses: Ag19.1, C44.08, H6.39
Embodiment 3:
Be mixed and made into solvent orange 2 A with 50% sucrose solution and glycerol by 1: 1 (volume), take by weighing the 40mg Potenlini silver amount of placing and in, splash into after a small amount of solvent A makes it fully emulsified, supply solvent to 10ml, promptly pharmaceutically acceptable after shaking up.
Embodiment 4:
The antibacterial activity test of Potenlini silver
One, material
Bacterium: streptococcus aureus (S.auceus), Bacillus subtilus (B.Subtilis), intestinal bacteria (E.COli), Pseudomonas aeruginosa (P.aeruginosa), fungi black-koji mould (A.niger), Candida albicans (C.alb Φ icoms).
Substratum: use the nutrient agar medium culturing bacterium, PDA agar is cultivated black-koji mould, and YPD Agar is cultivated Candida albicans.
Bacteria suspension preparation: get the fresh bacterial classification-cup after the activation respectively, be inoculated in the corresponding nutrient solution of 5ml, 28 ℃ of temperature were cultivated 20 hours.
Method: adopt dull and stereotyped diffusion process
Evaluation criteria: antibacterial circle diameter Φ＜10mm, insensitive; Φ is 10-15mm, sensitivity, and Φ＞15mm is extremely responsive.
Experimental result:
Claims (5)
1, a kind of compound is characterized in that this compound is a Potenlini silver, and molecular formula is C42H60O16Ag2 (15) H2O;
2, a kind of method for preparing compound Potenlini silver as claimed in claim 1 is characterized in that the concrete operations of method are:
Get a certain amount of Potenlini (salt) with 1: 1-1: 20 ratio, add ethanol (30-80%) solution, stir down at 25-80 ℃, make its dissolving, slowly add stoichiometric silver nitrate solution (being made into 0.05-1M concentration) with water, lucifuge, reacted 3-8 hour down at 25-60 ℃, ageing 8-24 hour, filter, with frozen water or absolute ethanol washing, under 20-80 ℃, be drying to obtain product;
3, a kind of preparation method of compound Potenlini silver as claimed in claim 1 is characterized in that said glycyrrhetate is an ammonium salt, sylvite, sodium salt;
4, a kind of purposes of compound Potenlini silver as claimed in claim 1, it is characterized in that this compound can be used for preparing antibiotic, the externally applied medicine of anti-virus infection;
5, a kind of purposes of compound Potenlini silver as claimed in claim 4 is characterized in that Potenlini silver and 5-50% sucrose solution and polyvalent alcohol by 1: it is that 1-10% suspension or content are the affected part that 0.5% solution directly is coated on infection that the solution mixing of the mixed of 0.1-1 (volume) is made content.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96108733A CN1063184C (en) | 1996-06-20 | 1996-06-20 | Compound-silver glycyrrhetate preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96108733A CN1063184C (en) | 1996-06-20 | 1996-06-20 | Compound-silver glycyrrhetate preparation method and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1169435A true CN1169435A (en) | 1998-01-07 |
| CN1063184C CN1063184C (en) | 2001-03-14 |
Family
ID=5120076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96108733A Expired - Fee Related CN1063184C (en) | 1996-06-20 | 1996-06-20 | Compound-silver glycyrrhetate preparation method and use thereof |
Country Status (1)
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|---|---|
| CN (1) | CN1063184C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827634B (en) * | 2005-03-04 | 2010-09-29 | 北京美倍他药物研究有限公司 | Nitrate derivatives of glycyrrhetic acid and glycyrrhetinic acid and pharmaceutical use thereof |
| CN103242392A (en) * | 2012-02-13 | 2013-08-14 | 南京华狮化工有限公司 | Novel glycyrrhizic acid double salt, and preparation and application thereof |
| CN103242391A (en) * | 2012-02-13 | 2013-08-14 | 南京华狮化工有限公司 | Method for preparing strontium glycyrrhetate compound, and product and application thereof |
| CN104861016A (en) * | 2015-03-01 | 2015-08-26 | 李玉山 | Glycyrrhizic acid metal complex preparation method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1004354B (en) * | 1985-06-25 | 1989-05-31 | 江苏省植物研究所 | Separation and purification of high purity crystalline licoricic acid |
| CN1026983C (en) * | 1988-06-30 | 1994-12-14 | 兰州大学 | Production process of edible sweet extract from licorice roots |
-
1996
- 1996-06-20 CN CN96108733A patent/CN1063184C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827634B (en) * | 2005-03-04 | 2010-09-29 | 北京美倍他药物研究有限公司 | Nitrate derivatives of glycyrrhetic acid and glycyrrhetinic acid and pharmaceutical use thereof |
| CN103242392A (en) * | 2012-02-13 | 2013-08-14 | 南京华狮化工有限公司 | Novel glycyrrhizic acid double salt, and preparation and application thereof |
| CN103242391A (en) * | 2012-02-13 | 2013-08-14 | 南京华狮化工有限公司 | Method for preparing strontium glycyrrhetate compound, and product and application thereof |
| CN103242391B (en) * | 2012-02-13 | 2016-04-13 | 南京华狮化工有限公司 | A kind of prepare method of strontium glycyrrhetate compound and products thereof and application |
| CN103242392B (en) * | 2012-02-13 | 2016-04-13 | 南京华狮化工有限公司 | A kind of glycyrrhizic acid double salt and preparation and application thereof |
| CN104861016A (en) * | 2015-03-01 | 2015-08-26 | 李玉山 | Glycyrrhizic acid metal complex preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1063184C (en) | 2001-03-14 |
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