CN116942776A - Pharmaceutical composition for treating urine retention, preparation and application thereof - Google Patents
Pharmaceutical composition for treating urine retention, preparation and application thereof Download PDFInfo
- Publication number
- CN116942776A CN116942776A CN202311209045.5A CN202311209045A CN116942776A CN 116942776 A CN116942776 A CN 116942776A CN 202311209045 A CN202311209045 A CN 202311209045A CN 116942776 A CN116942776 A CN 116942776A
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- China
- Prior art keywords
- parts
- pharmaceutical composition
- urine retention
- preparation
- treating urine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
The application discloses a pharmaceutical composition for treating urine retention, a preparation and application thereof, wherein the pharmaceutical composition comprises the following components in parts by weight: 1-10 parts of vinegar tortoise shell, 1-10 parts of fructus alpiniae oxyphyllae, 1-10 parts of semen cuscutae, 1-10 parts of semen astragali complanati, 1-10 parts of raspberry, 1-10 parts of lysimachia christinae, 0.5-5 parts of rush, 1-10 parts of vinegar corydalis tuber, 1-10 parts of lindera root, 1-10 parts of achyranthes root, 0.5-5 parts of amber, 1-10 parts of radix rehmanniae, 0.5-5 parts of tree peony bark, 1-10 parts of rhizoma atractylodis stir-fried with bran, 1-10 parts of rhizoma dioscoreae stir-fried with bran and 1-10 parts of cardamom. The pharmaceutical composition can be added with pharmaceutically acceptable auxiliary materials to prepare a preparation. The pharmaceutical composition and the preparation can be used for treating urine retention.
Description
Technical Field
The application belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating urine retention, a preparation and application thereof.
Background
In modern life, various diseases are layered endlessly, many people are bothered by different diseases, and the health condition of people is more and more important by people in all communities. The male disease is a hot topic next to the gynecological disease, and is a health element which plagues the vast male siblings. Dysuria (prostatitis) is a common disease type among men's diseases. Uroschesis is the name of traditional Chinese medicine, and in modern medicine, prostatitis and other diseases of male reproduction are corresponding. Its main symptoms are small urine volume, difficult urination and even blocked urine. In traditional Chinese medicine, urine is not smooth, dribble is short, and the disease is slow, so that urine is retained; the blockage of urine, the blockage of fluid, and the urgent symptoms of disease are called "closed".
The etiology of uroschesis mainly comprises invasion of exogenous evil, improper diet, emotional internal injury, internal stagnation of phlegm and chronic diseases due to deficiency. The basic pathogenesis is dysfunction of kidney and bladder qi. The downward flow of damp-heat and deficiency of kidney-yang are the main causes of dysfunction of kidney and bladder in qi transformation. "Su Mi-Ling lan Mi Dian Lun (Su Mi-Ren-Solanum): the body fluids of the bladder, the state, are stored as far as the qi transformation can take place. The theory of disease sources and urine theory: the urine is not easy, and … … is also heated in the bladder and kidney, and da Cheng is hot and causes the urine to be difficult. "the bladder qi is not authorized due to various reasons, and is associated with each other, and the bladder qi is damaged due to accumulation of long-term qi, and the bladder qi is blocked by damp-heat, the qi is unfavorable, the frequent urination is not easy to drip, or is short and red, and the amount of the urine is less and the urine is burnt; the kidney qi is tired and the bladder is not authorized to be gasified, so that urine is not easy to drip, or is not comfortable, and urination is weak, and aversion to cold, cold limbs, cold waist and knees and soreness and weakness are often accompanied.
At present, no specific medicine is available in the market for the retention of urine, and the traditional Chinese medicine is mainly used for conditioning and self-functional exercise and improving diet and living habit; western medicine mainly adopts antibacterial drugs and nonsteroidal anti-inflammatory drugs as main treatment modes. Because the disease can not be treated by operation, rehabilitation training, diet control, self-regulation and the like are mainly adopted, and the treatment of western medicines has great influence on liver and kidney functions and can not be taken for a long time.
Disclosure of Invention
Aiming at the defects existing in the prior art, the application aims to provide a pharmaceutical composition for treating urine retention, a preparation and application thereof. The pharmaceutical composition can be used for treating urine retention, and particularly has a good treatment effect on urine retention caused by damp-heat downward flow and kidney qi deficiency.
The application aims at realizing the following technical scheme: the pharmaceutical composition for treating urine retention consists of the following components in parts by weight: 1-10 parts of vinegar tortoise shell, 1-10 parts of fructus alpiniae oxyphyllae, 1-10 parts of semen cuscutae, 1-10 parts of semen astragali complanati, 1-10 parts of raspberry, 1-10 parts of lysimachia christinae, 0.5-5 parts of rush, 1-10 parts of vinegar corydalis tuber, 1-10 parts of lindera root, 1-10 parts of achyranthes root, 0.5-5 parts of amber, 1-10 parts of radix rehmanniae, 0.5-5 parts of tree peony bark, 1-10 parts of rhizoma atractylodis stir-fried with bran, 1-10 parts of rhizoma dioscoreae stir-fried with bran and 1-10 parts of cardamom.
In the field of traditional Chinese medicine, urine retention is mainly in the urinary bladder and kidney, and also has a close relationship with the qi transformation of the triple energizer. Traditional Chinese medicine considers that kidney yang is insufficient, fire of the vital gate is weakened, viscera qi is not in the same state, so that urinary bladder qi is not authorized, and urine retention is caused. The damp-heat accumulation in the lower energizer and the adverse qi transformation of the bladder can lead to the difficulty in dribbling urine, or reddish urine, less consumption and burning sensation; failure of kidney-yang and bladder qi failing to control, it is manifested as difficulty in urination, or difficulty in urination; kidney yang failing to nourish the body, the body will be pale with spirit, weak, aversion to cold, cold limbs, cold waist and knees, soreness and weakness. According to the principle of "Fu Zhong general usage", treatment should be mainly performed with general usage. The application considers that the retention of urine due to deficiency syndrome should be treated by the method of invigorating spleen and kidney to promote qi transformation, and the urination is performed.
The application uses three ingredients of tortoise shell (vinegar), fructus alpiniae oxyphyllae and radix rehmanniae as monarch drugs, the tortoise shell is sweet and cold, the kidney is benefited, the bone is strengthened, and the yin is nourished and the yang is subdued; the dried rehmannia root is sweet and cold, and can clear heat and cool blood, nourish yin and promote the production of body fluid; fructus alpiniae oxyphyllae is pungent and warm, warms kidney and consolidates semen, warms spleen and reduces urine, and the three are combined to play roles of tonifying kidney and warming spleen, clearing heat and removing steaming. Semen cuscutae, semen astragali complanati and raspberry are ministerial drugs, and can tonify liver and kidney, arrest semen and reduce urine, and fill the deficiency of monarch drugs. Herba Lysimachiae Christinae, medulla Junci, rhizoma corydalis and radix Linderae are used as adjuvant drugs, herba Lysimachiae Christinae can clear damp heat in liver and gallbladder, and remove damp heat in lower jiao, and medulla Junci, rhizoma corydalis and radix Linderae are added to achieve effects of clearing heat, promoting diuresis and treating stranguria. Achyranthes root, amber, tree peony bark, rhizoma atractylodis, chinese yam and cardamom are used as guiding drugs, which not only strengthen the effects of tonifying kidney and regulating qi, clearing heat and removing dampness, but also guide drugs to enter meridians, so that the drugs can reach the affected parts, and the effect of tonifying kidney and promoting diuresis of the whole prescription is enhanced.
All Fang Yi kidney can regulate qi, remove damp-heat, tonify kidney and spleen, clear damp-heat of middle energizer, and tonify liver and kidney.
The application has the beneficial effects that:
the application mainly aims at the urine retention of kidney qi deficiency and damp-heat downward flow in traditional Chinese medicine diagnosis. Based on the existing traditional Chinese medicine formula with good effect aiming at the disease, the traditional Chinese medicine formula preparation provided by the application is not available. The traditional Chinese medicine has the inherent advantages of small damage to liver and kidney functions and wide application range in treating diseases, and can be modified clinically to be used flexibly. The prescription has the advantages of being delicate in compatibility, taking care of both the tonifying and discharging, and improving the degree of the disease. Unlike the traditional treatment principle of "Fu Xuan Zhong" in this application, it is based on the general method, it also uses tortoise shell, dodder seed, semen astragali Complanati and raspberry to tonify kidney, warm yang and make up the deficiency of kidney. The kidney qi is sufficient to assist the qi transformation, so that the qi transformation is performed and urine is self-communicated. The application aims at tonifying liver and kidney, clearing heat and promoting diuresis, and the whole formula can tonify liver, spleen and kidney deficiency, assist triple energizer qi and kidney yang and qi and water.
Detailed Description
The present application will be further described with reference to examples, but the present application is not limited to the examples.
The pharmaceutical composition for treating urine retention consists of the following components in parts by weight: 1-10 parts of vinegar tortoise shell, 1-10 parts of fructus alpiniae oxyphyllae, 1-10 parts of semen cuscutae, 1-10 parts of semen astragali complanati, 1-10 parts of raspberry, 1-10 parts of lysimachia christinae, 0.5-5 parts of rush, 1-10 parts of vinegar corydalis tuber, 1-10 parts of lindera root, 1-10 parts of achyranthes root, 0.5-5 parts of amber, 1-10 parts of radix rehmanniae, 0.5-5 parts of tree peony bark, 1-10 parts of rhizoma atractylodis stir-fried with bran, 1-10 parts of rhizoma dioscoreae stir-fried with bran and 1-10 parts of cardamom.
Preferably, the composition comprises the following components in parts by weight: 3-10 parts of vinegar tortoise shell, 3-10 parts of fructus alpiniae oxyphyllae, 3-10 parts of semen cuscutae, 3-10 parts of semen astragali complanati, 3-10 parts of raspberry, 3-10 parts of lysimachia christinae, 1-5 parts of rush, 3-10 parts of vinegar corydalis tuber, 3-10 parts of lindera root, 3-10 parts of achyranthes root, 1-5 parts of amber, 3-10 parts of radix rehmanniae, 1-5 parts of tree peony bark, 3-10 parts of rhizoma atractylodis stir-fried with bran, 3-10 parts of rhizoma dioscoreae stir-fried with bran and 3-10 parts of cardamom.
Preferably, the composition comprises the following components in parts by weight: 6-10 parts of vinegar tortoise shell, 5-10 parts of fructus alpiniae oxyphyllae, 3-10 parts of semen cuscutae, 3-9 parts of semen astragali complanati, 3-9 parts of raspberry, 3-10 parts of lysimachia christinae, 3-9 parts of rush, 3-10 parts of vinegar corydalis tuber, 3-10 parts of lindera root, 3-10 parts of achyranthes root, 1-6 parts of amber, 3-10 parts of radix rehmanniae, 3-5 parts of tree peony bark, 3-10 parts of rhizoma atractylodis stir-fried with bran, 3-10 parts of rhizoma dioscoreae stir-fried with bran and 3-10 parts of cardamom.
Further, the pharmaceutical composition also comprises 6-10 parts of phellodendron bark, 15-30 parts of talcum, 15-30 parts of plantain seed and 15-30 parts of alisma orientale.
Further, the pharmaceutical composition also comprises 5-20 parts of codonopsis pilosula, 15-20 parts of bighead atractylodes rhizome, 10-20 parts of cinnamon, 15-30 parts of Polyporus, 6-10 parts of radix bupleuri and 15-30 parts of poria cocos.
Further, the pharmaceutical composition also comprises 15-30 parts of cassia twig, 10-20 parts of rehmannia, 10-30 parts of Chinese yam, 10-20 parts of cornel, 15-30 parts of plantain seed and 15-30 parts of rhizoma alismatis.
Further, the pharmaceutical composition also comprises 10-15 parts of dwarf lilyturf tuber, 10-20 parts of reed rhizome, 10-20 parts of cortex lycii radicis, 10-20 parts of plantain seed and 15-30 parts of Polyporus.
The preparation of the pharmaceutical composition for treating urine retention is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition.
The preparation is in the form of decoction, granule, paste, capsule or pill prepared by conventional method.
A preparation method of a preparation of a pharmaceutical composition for treating urine retention, which comprises the following steps:
the pharmaceutical composition is crushed into fine powder, sieved, evenly mixed, and added with proper amount of water for making pills with 30-40 parts of refined honey for every 100 parts of powder, covered with medicinal carbon, dried and polished to obtain the pharmaceutical composition.
The pharmaceutical composition can be used for preparing medicines for treating urine retention.
The preparation of the pharmaceutical composition can be used for preparing medicines for treating urine retention.
Example 1
A pharmaceutical composition for treating urine retention comprises the following components: 10g of vinegar tortoise shell, 10g of fructus alpiniae oxyphyllae, 10g of semen cuscutae, 10g of semen astragali complanati, 10g of raspberry, 10g of lysimachia christinae hance, 5g of rush, 10g of vinegar rhizoma corydalis, 10g of combined spicebush root, 10g of achyranthes root, 5g of amber, 10g of radix rehmanniae, 5g of cortex moutan, 10g of rhizoma atractylodis stir-fried with bran, 10g of rhizoma dioscoreae stir-fried with bran and 10g of cardamom.
Example 2
A pharmaceutical composition for treating urine retention comprises the following components: 9g of vinegar tortoise shell, 9g of fructus alpiniae oxyphyllae, 9g of semen cuscutae, 9g of semen astragali complanati, 9g of raspberry, 9g of lysimachia christinae hance, 5g of rush, 9g of vinegar corydalis tuber, 9g of combined spicebush root, 9g of achyranthes root, 5g of amber, 9g of radix rehmanniae, 5g of cortex moutan, 9g of bran-fried rhizoma atractylodis, 9g of bran-fried yam and 9g of cardamom.
Example 3
A pharmaceutical composition for treating urine retention comprises the following components: 9g of vinegar tortoise shell, 9g of fructus alpiniae oxyphyllae, 9g of semen cuscutae, 9g of semen astragali complanati, 9g of raspberry, 9g of lysimachia christinae hance, 3g of rush, 6g of vinegar corydalis tuber, 6g of combined spicebush root, 6g of achyranthes root, 3g of amber, 6g of radix rehmanniae, 3g of cortex moutan, 5g of bran-fried rhizoma atractylodis, 5g of bran-fried yam and 5g of cardamom.
Example 4
A pharmaceutical composition for treating urine retention comprises the following components: 6g of vinegar tortoise shell, 6g of fructus alpiniae oxyphyllae, 6g of semen cuscutae, 6g of semen astragali complanati, 6g of raspberry, 6g of lysimachia christinae hance, 3g of rush, 6g of vinegar corydalis tuber, 6g of combined spicebush root, 6g of achyranthes root, 3g of amber, 6g of radix rehmanniae, 3g of tree peony bark, 6g of rhizoma atractylodis stir-fried with bran, 6g of rhizoma dioscoreae stir-fried with bran and 6g of cardamom.
Example 5
A pharmaceutical composition for treating urine retention comprises the following components: 5g of vinegar tortoise shell, 5g of fructus alpiniae oxyphyllae, 5g of semen cuscutae, 5g of semen astragali complanati, 5g of raspberry, 5g of lysimachia christinae hance, 2g of rush, 5g of vinegar corydalis tuber, 5g of combined spicebush root, 5g of achyranthes root, 2g of amber, 5g of radix rehmanniae, 2g of cortex moutan, 5g of bran-fried rhizoma atractylodis, 5g of bran-fried yam and 5g of cardamom.
Example 6
A pharmaceutical composition for treating urine retention comprises the following components: 3g of vinegar tortoise shell, 3g of fructus alpiniae oxyphyllae, 3g of semen cuscutae, 3g of semen astragali complanati, 3g of raspberry, 3g of lysimachia christinae hance, 1g of rush, 3g of vinegar rhizoma corydalis, 3g of combined spicebush root, 3g of achyranthes root, 1g of amber, 3g of radix rehmanniae, 1g of cortex moutan, 3g of bran-fried rhizoma atractylodis, 3g of bran-fried rhizoma dioscoreae and 3g of cardamom.
Example 7
A pharmaceutical composition for treating urine retention comprises the following components: 1g of vinegar tortoise shell, 1g of fructus alpiniae oxyphyllae, 1g of semen cuscutae, 1g of semen astragali complanati, 1g of raspberry, 1g of lysimachia christinae hance, 0.5g of rush, 1g of vinegar corydalis tuber, 1g of lindera root, 1g of achyranthes root, 0.5g of amber, 1g of radix rehmanniae, 0.5g of tree peony bark, 1g of rhizoma atractylodis stir-fried with bran, 1g of rhizoma dioscoreae stir-fried with bran and 1g of cardamom.
Example 8
A pharmaceutical composition for treating urine retention is prepared by pulverizing the pharmaceutical composition according to any one of examples 1-6 into fine powder, sieving, and mixing. Adding 30-40g of refined honey into 100g of powder, making into pill, covering with medicinal charcoal, drying, polishing, and making into 1000 g. Making into tablet, powder, pill, etc.
Example 9
A pharmaceutical composition for treating urine retention is prepared from cortex Phellodendri 10g, pulvis Talci 10g, semen plantaginis 15g, and Alismatis rhizoma 20g based on example 1.
Example 10
A pharmaceutical composition for treating urine retention is prepared from cortex Phellodendri 6g, pulvis Talci 15g, semen plantaginis 20g, and Alismatis rhizoma 15g based on example 1.
Example 11
A pharmaceutical composition for treating urine retention is prepared by adding 15g of radix Codonopsis, 15g of Atractylodis rhizoma, 10g of cortex Cinnamomi, 15g of Polyporus, 9g of bupleuri radix and 15g of Poria based on example 3.
Example 12
A pharmaceutical composition for treating urine retention is prepared by adding radix Codonopsis 20g, atractylodis rhizoma 18g, cortex Cinnamomi 15g, polyporus 20g, bupleuri radix 6g, and Poria 20g based on example 2.
Example 13
A pharmaceutical composition for treating urine retention is prepared by adding radix Codonopsis 10g, atractylodis rhizoma 20g, cortex Cinnamomi 12g, polyporus 18g, bupleuri radix 9g, and Poria 15g based on example 1.
Example 14
A pharmaceutical composition for treating urine retention is prepared by adding ramulus Cinnamomi 30g, rehmanniae radix 20g, rhizoma Dioscoreae 30g, fructus evodiae 20g, semen plantaginis 30g, and Alismatis rhizoma 30g based on example 3.
Example 15
A pharmaceutical composition for treating urine retention is prepared by adding ramulus Cinnamomi 15g, rehmanniae radix 10g, rhizoma Dioscoreae 10g, fructus evodiae 10g, semen plantaginis 15g, and Alismatis rhizoma 15g based on example 1.
Example 16
A pharmaceutical composition for treating urine retention is prepared from radix Ophiopogonis 15g, rhizoma Phragmitis 20g, cortex Lycii 20g, semen plantaginis 20g, and Polyporus 30g.
Example 17
A pharmaceutical composition for treating urine retention is prepared from radix Ophiopogonis 10g, rhizoma Phragmitis 15g, cortex Lycii 15g, semen plantaginis 15g, and Polyporus 20g.
Example 18
A pharmaceutical composition for treating urine retention is prepared by adding radix Ophiopogonis 10g, rhizoma Phragmitis 10g, cortex Lycii 10g, semen plantaginis 10g, and Polyporus 15g based on example 3.
Example 19
A pharmaceutical composition for treating urine retention is prepared from cortex Phellodendri 6g, pulvis Talci 15g, semen plantaginis 15g, and Alismatis rhizoma 15g based on example 7.
Example 20
A pharmaceutical composition for treating urine retention is prepared by adding radix Codonopsis 5g, atractylodis rhizoma 15g, cortex Cinnamomi 10g, polyporus 15g, bupleuri radix 6g, and Poria 15g based on example 7.
Example 21
A pharmaceutical composition for treating urine retention is prepared by adding ramulus Cinnamomi 15g, rehmanniae radix 10g, rhizoma Dioscoreae 10g, fructus evodiae 10g, semen plantaginis 15g, and Alismatis rhizoma 15g based on example 7.
Example 22
A pharmaceutical composition for treating urine retention is prepared from radix Ophiopogonis 10g, rhizoma Phragmitis 10g, cortex Lycii 10g, semen plantaginis 10g, and Polyporus 15g.
Example 23
A pharmaceutical composition for treating urine retention is prepared from radix Ophiopogonis 15g, rhizoma Phragmitis 20g, cortex Lycii 20g, semen plantaginis 20g, and Polyporus 30g.
Example 24
A pharmaceutical composition for treating urine retention is prepared from radix Ophiopogonis 15g, rhizoma Phragmitis 20g, cortex Lycii 15g, semen plantaginis 15g, and Polyporus 20g in the form of example 1.
Application example-the pharmaceutical composition of the application is used for treating urine retention.
1. Research method
Patients meeting the urine retention (disease) inclusion standard within nearly five years are selected, and the medicine composition is used for treatment, so that the clinical curative effect and adverse reaction of the patients are observed.
2. Study object
Patients with urine retention due to deficiency of kidney-qi and downward flow of damp-heat.
3. Diagnostic criteria
Reference is made to the guidelines of clinical research on new Chinese medicine (1993 edition).
4. Traditional Chinese medicine diagnosis standard for waiting for symptoms
Diagnostic criteria for kidney-qi deficiency:
main symptoms are as follows: aversion to cold, cold limbs, soreness of waist and knees.
Secondary symptoms: dribbling after urination, listlessness, stomach nourishing, or premature ejaculation, pale tongue with thin white coating, deep and slow pulse.
A pale tongue with white and slippery coating and a deep and thready pulse.
The patients with 2 main symptoms and 2 secondary symptoms can be diagnosed with kidney qi deficiency.
Diagnostic criteria for downward flow of damp-heat:
main symptoms are as follows: frequent urination, urgent urination, painful urination.
Secondary symptoms: the urethra is burning, the urethra is white and turbid, the scrotum is moist, dribbling after urine, the tongue is red with yellow or yellow greasy coating, and the pulse is slippery.
Has the main symptoms of 2 items and the secondary symptoms of 2 items, and can diagnose the downward flow of damp-heat.
5. Inclusion criteria
1. Meets the diagnosis standard of the traditional Chinese medicine for treating uroschesis with kidney qi deficiency and damp-heat downward flow;
2. age 18-80 years old, and is not limited for men and women;
6. exclusion criteria
1. The traditional Chinese medicine urine retention diagnosis standard is not met;
2. oliguria or lack thereof due to urinary tract stones, tumors, and acute and chronic renal failure;
3. syndrome of stranguria;
4. women under 18 years of age, or over 80 years of age, pregnant or lactating;
5. serious primary diseases such as cardiovascular, liver, kidney and hematopoietic system are combined;
6. mental patients;
7. allergic to the study drug;
8. the inclusion standard is not met, and the administration is not regulated, so that the treatment effect or the influence of incomplete data and the like on the treatment effect or the safety judgment cannot be judged.
7. Administration method
1. Oral pills. 10g (about 1 bottle cap) at a time, 3 times a day, taken after meals; or follow the doctor's advice.
2. During the administration period, spicy and fragrant and dry food is forbidden.
3. Other medications are discontinued during treatment.
8. Therapeutic effect criterion
1. And (3) healing: the symptoms of deficiency of kidney-qi and damp-heat downward flow disappear in clinic.
2. The effect is shown: the symptoms of deficiency of kidney-qi and damp-heat downward flow are obviously improved.
3. The method is effective: the symptoms of deficiency of kidney-qi and damp-heat downward flow are all improved in clinic.
4. Invalidation: clinically, the symptoms of deficiency of kidney-qi and damp-heat downward flow have no obvious changes.
9. Summary of clinical efficacy
The kidney-tonifying and dehumidifying pill is used in a hospital preparation in the form of a hospital preparation, and is used in a hospital for adjusting, and the patients using the kidney-tonifying and dehumidifying pill are observed to be nearly 1.5 ten thousand people in the total from 2017 to 2023, and the clinical use curative effects are counted, wherein the following table is provided:
Time | healing | Has obvious effect | Effective and effective | Invalidation of | Total cases of | Effective rate of |
2017 (2017) | 466 | 104 | 1140 | 117 | 1827 | 93.60% |
2018 | 266 | 96 | 1432 | 108 | 1902 | 94.32% |
2019 | 368 | 122 | 1691 | 111 | 2292 | 95.16% |
2020, 2020 | 287 | 111 | 1724 | 91 | 2213 | 95.89% |
2021 | 369 | 148 | 2169 | 111 | 2797 | 96.03% |
2022 years | 422 | 133 | 2234 | 135 | 2924 | 95.38% |
2023 years | 233 | 107 | 1613 | 87 | 2040 | 95.74% |
The above table shows that the recipe has obvious clinical curative effect and total effective rate higher than 90%.
The Chinese medicine is modified according to the syndrome differentiation, and the recipe is modified according to the syndrome. This indicates that the classical prescriptions of traditional Chinese medicine are not deduced according to five elements of yin and yang, but are composed of drugs with stronger pertinence according to the syndrome candidates of the disease. Single symptoms, single medication, complex symptoms and complex medication. Therefore, any classical recipe can be modified according to clinical practice, not only the drugs but also the target drugs. In a word, the traditional Chinese medicine is a living science, and the clinical dialectical treatment needs to be widely thought, is flexible to use and is contraindicated for moving hard covers.
In clinic, in the course of the development of each disease, due to the struggle between the pathogenic factors and the healthy energy and the congenital endowment, living and living conditions, working conditions and difference of emotional changes of the patient, different patients and the same patient may have different symptoms at different stages, and the patients must be modified and modified according to the disease conditions of the patients to obtain good treatment effects. The prescriptions of the syndrome differentiation of the patients should be kept, and the prescriptions of the syndrome differentiation of the patients should be kept, so that the recipe is effective.
Therefore, the corresponding embodiments of the curative effect statistics table in the application cannot be listed one by one, and for those skilled in the art, the corresponding curative effect can be achieved by adding and subtracting according to different patients within the dosage and the application range defined by the application.
10. Adverse reactions
Clinical application shows no toxic side effect and adverse reaction.
11. Typical cases
Case 1
Wang somebody, male, 41 years old. Date of first visit: 2022, 3 and 6.
Patients frequent urination, urgent urination, incomplete urination, soreness of waist, testicle pain, and yellow urine after 2 months of disease course.
Pale and reddish tongue and deep and thready pulse.
Diagnosis of the traditional Chinese medicine, white turbidity.
Western diagnosis: chronic prostatitis.
The syndrome is: downward flow of damp-heat.
The treatment method comprises the following steps: clear heat and promote diuresis.
The prescription comprises the following components: pill 3 bottle. The oral liquid is taken 3 times daily and 10g daily.
And re-diagnosing after 1 month. The symptoms of frequent urination, urgent urination and incomplete urination are basically improved, the testis pain is relieved, and after 5 bottles of kidney-tonifying and dehumidifying pills are opened, the patients are good.
Case 2
Liu somebody, man, 24 years old. Date of first visit: 2021, 1 and 27.
Patients with premature ejaculation, urgent urination, frequent urination, soreness of waist, white tongue, red tip and deep and thready pulse.
Diagnosis of the traditional Chinese medicine, white turbidity.
Western diagnosis: chronic prostatitis.
The syndrome is: downward flow of damp-heat and deficiency of both liver and kidney.
The treatment method comprises the following steps: clear heat and promote diuresis, tonify kidney and invigorate spleen.
The prescription comprises the following components: pill 3 bottle. The oral liquid is taken 3 times daily and 10g daily.
And re-diagnosing after 1 month. Soreness of waist, smooth urine and premature ejaculation.
Case 3
Some of the paragraphs, men, 42 years old, date of first visit: 2022, 10 and 18 days.
Patients tinnitus, poor quality of sexual life, soreness of waist, incomplete urine, and nocturia 2 times. Pale red tongue, white coating and wiry pulse.
Diagnosis of the traditional Chinese medicine, white turbidity.
Western diagnosis: chronic prostatitis.
The syndrome is: downward flow of damp-heat and deficiency of both liver and kidney.
The treatment method comprises the following steps: clear heat and promote diuresis, tonify kidney and invigorate spleen.
The prescription comprises the following components: pill 6 bottles. The oral liquid is taken 3 times daily and 10g daily.
And re-diagnosing after 2 months. Soreness of waist, smooth urine, disappearance of tinnitus, reduction of nocturia and improvement of sexual life quality. And then opening 6 bottles for consolidation.
Case 4
And somebody, men, 31 years old. Date of first visit: 2022, 11 and 13.
Patients have poor sexual life quality, urinate 2 times at night, and are not full of urine for pregnancy. The tip of the tongue is red, and the coating is thin and white.
Diagnosis of the traditional Chinese medicine, white turbidity.
Western diagnosis: chronic prostatitis.
The syndrome is: downward flow of damp-heat and deficiency of both liver and kidney.
The treatment method comprises the following steps: clear heat and promote diuresis, tonify kidney and invigorate spleen.
The prescription comprises the following components: pill 3 bottle. The oral liquid is taken 3 times daily and 10g daily.
After 2 months, the patient is re-diagnosed, the urine at night is reduced by 1 time, and the wife is pregnant.
Case 5
A man is about somewhere, and is 40 years old. Date of first visit: 2022, 11 and 20.
Headache, pricking and pain in urination, nocturia, itching urethra, prostatic hyperplasia, soreness of waist and urine waiting of patients. The tip of the tongue is red, and the coating is thin and white.
Diagnosis of the traditional Chinese medicine, white turbidity.
Western diagnosis: chronic prostatitis.
The syndrome is: downward flow of damp-heat.
The treatment method comprises the following steps: clear heat and promote diuresis.
The prescription comprises the following components: pill 3 bottle. The oral liquid is taken 3 times daily and 10g daily.
The symptoms were alleviated after 1 month, and 5 bottles were opened to consolidate the efficacy.
The above cases are only part of the cases observed clinically, and the pharmaceutical composition used is also only part of the pharmaceutical composition, and in actual clinical use, the dosage of the specific drug in the pharmaceutical composition can be arbitrarily selected within the scope of the application according to different clinical symptoms of patients.
In clinic, prescriptions can be adjusted and modified for different patients:
(1) If the patient has serious bladder damp-heat, 6-10 g of phellodendron bark, 15-30 g of talcum, 15-30 g of plantain seed and 15-30 g of alisma orientale can be added. The four above herbs all have the effects of clearing heat and promoting diuresis, and inducing diuresis for treating stranguria, and can enhance the effects of clearing heat and inducing diuresis in the recipe, especially the symptoms of scanty and reddish urine, dribbling and painful urination and the like caused by damp-heat in lower jiao.
(2) If spleen qi is not increased, 5-20 g of radix codonopsis pilosulae, 15-20 g of rhizoma atractylodis macrocephalae, 10-20 g of cinnamon, 15-30 g of Polyporus, 6-10 g of radix bupleuri and 15-30 g of poria can be added. Codonopsis pilosula, atractylodis rhizoma and cinnamon can warm and tonify spleen qi, promote spleen transportation and transformation; polyporus, bupleuri radix, and Poria are effective in promoting diuresis, relieving stranguria, clearing heat and dampness, and promoting the flow of qi and heat. Spleen qi can nourish the spleen qi, so that the spleen qi can transform and remove dampness and heat.
(3) For those with deficiency of kidney-yang and aversion to cold, ramulus Cinnamomi 15-30 g, rehmanniae radix 10-20 g, rhizoma Dioscoreae 10-30 g, fructus evodiae 10-20 g, semen plantaginis 15-30 g, and Alismatis rhizoma 15-30 g can be added. For urine retention with kidney yang deficiency, gui Zhi, di Huang and Zhu Yu are the products of warming spleen and kidney and tonifying yang qi, so spleen and kidney qi are tonifying, kidney can support water metabolism and spleen can transport water as much as possible. Then, the herb of plantain seed and alismatis can promote diuresis and treat stranguria, and can inhibit the temperature of cinnamon and cornel so as to avoid heat generation caused by excessive temperature.
(4) If the patient has excessive lung heat, 10-15 g of dwarf lilyturf tuber, 10-20 g of reed rhizome, 10-20 g of cortex lycii radicis, 10-20 g of plantain seed and 15-30 g of Polyporus can be added. For damp-heat in middle energizer, upper energizer is treated with wind-heat accumulation, so it is indicated for radix Ophiopogonis, rhizoma Phragmitis and cortex Lycii to nourish yin and clear heat, clear lung-heat accumulation, and semen plantaginis and Polyporus to clear heat and promote diuresis together with the recipe to clear damp-heat in lower energizer and moisten lung yin in upper energizer.
Claims (10)
1. The pharmaceutical composition for treating urine retention is characterized by comprising the following components in parts by weight: 1-10 parts of vinegar tortoise shell, 1-10 parts of fructus alpiniae oxyphyllae, 1-10 parts of semen cuscutae, 1-10 parts of semen astragali complanati, 1-10 parts of raspberry, 1-10 parts of lysimachia christinae, 0.5-5 parts of rush, 1-10 parts of vinegar corydalis tuber, 1-10 parts of lindera root, 1-10 parts of achyranthes root, 0.5-5 parts of amber, 1-10 parts of radix rehmanniae, 0.5-5 parts of tree peony bark, 1-10 parts of rhizoma atractylodis stir-fried with bran, 1-10 parts of rhizoma dioscoreae stir-fried with bran and 1-10 parts of cardamom.
2. A pharmaceutical composition for treating urine retention is characterized in that 6-10 parts of phellodendron, 15-30 parts of talcum, 15-30 parts of semen plantaginis and 15-30 parts of rhizoma alismatis are further added on the basis of the pharmaceutical composition of claim 1.
3. A pharmaceutical composition for treating urine retention is characterized in that 5-20 parts of radix codonopsis, 15-20 parts of bighead atractylodes rhizome, 10-20 parts of cinnamon, 15-30 parts of Polyporus, 6-10 parts of radix bupleuri and 15-30 parts of poria cocos are further added on the basis of the pharmaceutical composition of claim 1.
4. A pharmaceutical composition for treating urine retention is characterized in that 15-30 parts of cassia twig, 10-20 parts of rehmannia, 10-30 parts of Chinese yam, 10-20 parts of cornel, 15-30 parts of plantain seed and 15-30 parts of alisma are further added on the basis of the pharmaceutical composition of claim 1.
5. The pharmaceutical composition for treating urine retention is characterized in that 10-15 parts of dwarf lilyturf tuber, 10-20 parts of reed rhizome, 10-20 parts of cortex lycii radicis, 10-20 parts of plantain seed and 15-30 parts of grifola are further added on the basis of the pharmaceutical composition of claim 1.
6. A formulation of a pharmaceutical composition according to any one of claims 1 to 5, wherein the formulation is prepared from the pharmaceutical composition by adding pharmaceutically acceptable excipients.
7. The preparation of a pharmaceutical composition according to claim 6, wherein the preparation is in the form of a decoction, a granule, a paste, a capsule or a pill prepared according to a conventional method.
8. A method of preparing a formulation of the pharmaceutical composition of claim 6, comprising the steps of:
the pharmaceutical composition is crushed into fine powder, sieved, mixed evenly, 30-40 parts of refined honey is added into each 100 parts of powder to be made into pills, medicinal carbon covers are used for covering, and the pills are dried and polished to obtain the pharmaceutical composition.
9. Use of a pharmaceutical composition according to any one of claims 1 to 5 for the preparation of a medicament for the treatment of uroschesis.
10. Use of a formulation of a pharmaceutical composition as claimed in any one of claims 6 to 7 in the manufacture of a medicament for the treatment of uroschesis.
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