CN116898445A - Pressure identification system for human pharynx and upper esophageal sphincter - Google Patents
Pressure identification system for human pharynx and upper esophageal sphincter Download PDFInfo
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- 210000001942 upper esophageal sphincter Anatomy 0.000 title claims abstract description 218
- 210000003800 pharynx Anatomy 0.000 title claims abstract description 36
- 230000009747 swallowing Effects 0.000 claims abstract description 101
- 210000003026 hypopharynx Anatomy 0.000 claims abstract description 63
- 210000001184 pharyngeal muscle Anatomy 0.000 claims abstract description 53
- 210000003205 muscle Anatomy 0.000 claims abstract description 18
- 238000007405 data analysis Methods 0.000 claims abstract description 17
- 230000000284 resting effect Effects 0.000 claims abstract description 17
- 238000005070 sampling Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000004458 analytical method Methods 0.000 claims description 14
- 210000005070 sphincter Anatomy 0.000 claims description 12
- 241000167880 Hirundinidae Species 0.000 claims description 7
- 238000004590 computer program Methods 0.000 claims description 6
- 230000000630 rising effect Effects 0.000 claims description 6
- 238000009530 blood pressure measurement Methods 0.000 claims description 5
- 230000009748 deglutition Effects 0.000 claims description 3
- 238000013507 mapping Methods 0.000 claims description 3
- 230000003387 muscular Effects 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims 1
- 230000000152 swallowing effect Effects 0.000 abstract description 2
- 230000008602 contraction Effects 0.000 description 12
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- 230000002572 peristaltic effect Effects 0.000 description 8
- 230000001174 ascending effect Effects 0.000 description 5
- 208000019505 Deglutition disease Diseases 0.000 description 4
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- 238000010586 diagram Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
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- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
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- 208000002925 dental caries Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 201000006549 dyspepsia Diseases 0.000 description 1
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- 210000000111 lower esophageal sphincter Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/22—Ergometry; Measuring muscular strength or the force of a muscular blow
- A61B5/224—Measuring muscular strength
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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Abstract
The invention discloses a pressure identification system for the pharyngeal portion and the upper esophageal sphincter of a human body, which is characterized by comprising a data sampling module, a data display module and a data analysis module, wherein the data sampling module samples pressure data of the pharyngeal portion and the upper esophageal sphincter of the human body through a pressure measuring catheter so as to obtain corresponding pressure data and transmits the corresponding pressure data to the data display module; the data display module processes and converts the received pressure data into display data comprising a pressure curve image and a pressure high fraction cloud image. The invention discloses a pressure identification system for human pharynx and upper esophageal sphincter, which is combined with a pressure measuring catheter to accurately measure pressure, and can be applied to measuring jaw pharyngeal muscles, tongue root and hypopharynx muscle areas, and pressure changes of the upper esophageal sphincter areas in a resting state and a swallowing state, and observing coordination of swallowing actions.
Description
Technical Field
The invention belongs to the technical field of pressure identification of human pharyngeal and upper esophageal sphincter, and particularly relates to a pressure identification system for human pharyngeal and upper esophageal sphincter.
Background
Oropharyngeal dysphagia is considered the most common throat disorder clinically. Patients present with symptoms of discomfort such as feeling of swallowing obstruction, feeling of esophageal viscosity, dysphagia, post-sternal discomfort or pain, vomiting (at/after feeding), heartburn, acid regurgitation, reflux, chest pain, cough, asthma, pneumonia, caries, canker sore, otitis media, and abnormal throat. Uncoordinated pharyngeal contraction and upper esophageal sphincter relaxation are common causes of dysphagia and can be caused by a variety of nerve and muscle lesions.
The traditional pressure measuring system is mainly used for detecting the pressure of the upper esophageal sphincter, the esophageal body and the lower esophageal sphincter, and is not specially used for further refinement and analysis of the coordination of upper sphincter relaxation and pharyngeal contraction. Research shows that the upper esophageal sphincter can be used for effectively measuring the resting pressure of the upper esophageal sphincter, the residual pressure of the upper esophageal sphincter, the relaxation duration, the peak value of pharyngeal cavity contraction, the contraction duration, the coordination of the upper esophageal sphincter relaxation and pharyngeal contraction, and the method has important judgment basis for diagnosing dysphagia patients.
Accordingly, the above problems are further improved.
Disclosure of Invention
The invention mainly aims to provide a pressure identification system for the pharyngeal portion and the upper esophageal sphincter of a human body, which is combined with a pressure measuring catheter to accurately measure pressure, can be applied to measuring jaw pharyngeal muscles, tongue root and hypopharynx muscle areas and pressure changes of the upper esophageal sphincter areas in a resting state and a swallowing state, and can observe coordination of swallowing actions.
In order to achieve the above object, the present invention provides a pressure recognition system for human pharynx and upper esophageal sphincter, comprising a data sampling module, a data display module and a data analysis module, wherein:
the data sampling module samples pressure data of the pharyngeal portion and the upper esophageal sphincter of the human body through the pressure measuring catheter so as to obtain corresponding pressure data and transmit the corresponding pressure data to the data display module;
the data display module processes and converts the received pressure data into display data comprising a pressure curve image and a pressure high-fraction cloud image;
the data analysis module automatically analyzes the stored display data so as to respectively acquire pressure information including jaw pharyngeal muscles, tongue roots, hypopharynx areas and upper esophageal sphincter.
As a further preferable technical solution of the foregoing technical solution, the automatic data analysis of the data analysis module is specifically implemented as follows:
determination of the pressure channel of the upper esophageal sphincter: in the data analysis module, a virtual analysis frame is set forward at the time beginning of the marking range (one marking corresponds to one frame, such as 'resting pressure', '5 ml swallowing', and the like, each marking frame has a starting position and a stopping position) and the time width is set to be T1, the area of the pressure curve (obtained from a pressure linear graph) of each channel (the pressure channel corresponding to a sensor) is averaged within the time width of T1, and the maximum integrated average channel is identified as the central channel C of the upper esophageal sphincter pressure channel ues At the same time calculate the resting pressure P of the upper esophageal sphincter Rest Average value P of pressure ave And baseline P base (baseline is the line segment that is the starting standard in the measurement, where the pressure data for a certain period of time is taken for the central channel and the standard deviation of this pressure data is calculated, when the standard deviation is > 1.0, the data segment is gradually removed from the pressure average P ave The absolute value of the removed pressure data is greater than the standard deviation, then the standard deviation of the removed pressure data is recalculated until the standard deviation is less than 1.0, the average value of the segment of data is taken as a baseline value), the starting position and the ending position of the upper esophageal sphincter pressure are calculated according to the baseline value of 80% on the upper and lower adjacent channels (nearby) through the peak of the central point of the upper esophageal sphincter, and the channel range of the upper esophageal sphincter is determined (such as C ues As the center point, the channel covered by the sphincter meets C ues -1 or C ues +1 on the channel meets the above baseline value);
relaxation time determination at upper esophageal sphincter deglutition: the relaxation time window of the upper esophageal sphincter during swallowing refers to the time that the pressure of the channel is reduced and the pressure low point is continuously maintained during swallowing, the pressure is reduced during swallowing of the central channel of the upper esophageal sphincter, the lowest point of the pressure which is continuously reduced is found, and the previous time is searched (left searching) until the current pressure point meets P base * (1-0.2), the current time point being the onset of relaxation patency upon swallowing of the upper esophageal sphincter, labeled TC1n; looking up at a later time (looking up to the right) until the current pressure point meets P base * (1-0.2), the current time point being the end of relaxation patency time when the upper esophageal sphincter swallows, labeled TC2n; the last esophageal sphincter relaxes this time swallow for a duration of gn=tc2n-TC 1n, n identified as the nth swallowing indicia;
determination of the jaw pharyngeal pressure channel and maximum pressure value and duration: the jaw pharyngeal pressure channel was determined by subtracting Slcm (preferably 8 cm) from the upper esophageal sphincter center channel distance, which was the jaw pharyngeal pressure analysis channel C1; finding out that the current peak point pressure of the jaw pharyngeal muscle pressure is F in the range of the esophageal sphincter swallowing relaxation time window Gn C1 Determining a peak value point C1T1n of the jaw pharyngeal muscle pressure, searching in the prior time, and determining a starting point C1TS1n of the jaw pharyngeal muscle pressure according to the fact that the current pressure value meets the current channel baseline (1+0.2); then searching for the following time, and determining a jaw pharyngeal muscle pressure end point C1TS2n according to the fact that the current pressure value meets the current channel baseline (1+0.2); the duration of the swallowing jaw pharyngeal muscle pressure is C1Fn=C1TS 2n-C1TS1n, and n is marked as an nth swallowing mark;
determination of tongue root and hypopharynx region pressure channel and maximum pressure value and duration of pressure: the tongue root and hypopharynx region pressure channel is determined by subtracting S2cm (preferably 5 cm) from the upper esophageal sphincter central channel distance, which is the tongue root and hypopharynx region pressure analysis channel C2; finding out the peak pressure of the pressure peak points of the current tongue root and hypopharynx muscle area as F in the range of the upper esophageal sphincter swallowing relaxation time window Gn C2 Determining peak point C2T1n of tongue root and hypopharynx region pressure, searching in the previous time, and determining tongue root and hypopharynx according to the current pressure value satisfying the current channel baseline (1+0.2)A muscular region pressure start point C2TS1n; then searching for the time after the time, and determining the pressure end points C2TS2n of the tongue root and the hypopharynx region according to the fact that the current pressure value meets the current channel baseline (1+0.2); the duration of the pressure of the swallow tongue root and the hypopharynx is C2 Fn =c2ts 2n-C2TS1n, n identified as the nth swallowing signature;
after the pressure analysis channels corresponding to the jaw pharyngeal muscles, the tongue root and the hypopharynx regions are determined, pressure changes generated when the jaw pharyngeal muscles, the tongue root and the hypopharynx regions are swallowed are sequentially analyzed within the marking time range of each marking as upper esophageal sphincter pressure measurement, so that corresponding pressure information is obtained.
As a further preferable technical scheme of the technical scheme, the pressure information of the jaw pharyngeal muscles, the tongue root and the hypopharynx muscle areas is specifically implemented as follows:
obtaining peak time C1T1n and position S1n when the jaw pharyngeal muscles swallow, obtaining peak time C2T1n and position S2n when the tongue root and hypopharynx regions swallow, and calculating an initial speed Vn= (S2 n-S1 n)/(C2T 1n-C1T1 n), wherein n is a swallowing mark number, and the numbers are sequentially numbered from n=1, 2,3.
Obtaining peak value P1n of the swallowing of the jaw pharyngeal muscle, wherein the corresponding peak value time is C1T1n; obtaining peak value P2n of the swallow of the tongue root and the hypopharyngeal muscle region, wherein the corresponding peak value time is C2T2n; wherein n is the swallowing indicia number described above;
searching forward at the peak value P1n of the jaw pharyngeal muscle, setting a point with the pressure meeting the current channel baseline of 120% as a starting position T1n_start of a jaw pharyngeal muscle pressure wave, searching forward after the peak value P1n of the jaw pharyngeal muscle, and setting a point with the pressure meeting the current channel baseline of 120% as an ending position T1n_end of the pressure wave; and the starting position t2n_start and ending position t2n_end of the pressure wave of the tongue root and hypopharynx region channels are calculated in the same manner; respectively calculating rising edge rate V of swallowing of jaw pharyngeal muscles Upper part n=p1n/(t1n_end-t1n_start), rising edge rate V of swallowing of tongue root and hypopharynx region Upper part n=p2n/(t2n_start-t2n_end); then, respectively calculating the time P1Tn=T1n-T1n_start of reaching the peak value when the jaw pharyngeal muscles swallow, and the time P2Tn=T2n-T2n_start of reaching the peak value when the tongue root and the hypopharynx muscles swallow; separately calculate the swallowing of the jaw pharyngeal musclesPressure duration p1ctn=t1n_end-t1n_start, pressure duration p2ctn=t2n_end-t2n_start when the tongue root and hypopharyngeal area swallow.
As a further preferable technical scheme of the technical scheme, the central channel C of the upper esophageal sphincter is determined ues The lowest pressure point, which is the lowest relaxation pressure point T3n when the Upper Esophageal Sphincter (UES) swallows, will then be retrieved in the swallowing frame (the virtual analysis frame is not visible in the figure, is virtually seen in the left part of the swallowing frame), the pressure value is P3n, where n is the swallowing mark number described above, and the following analysis is performed in connection with the tongue root and hypopharynx pressure channel:
pressure baseline P through the central point of the upper esophageal sphincter base Retrieving forward at the lowest pressure of relaxation T3n at the time of swallowing the upper esophageal sphincter, taking the point with the pressure value satisfying 80% or less of the pressure baseline as the initial position T3n_start of relaxation pressure (wave), retrieving backward at the lowest pressure of relaxation T3n at the time of swallowing the upper esophageal sphincter, taking the point with the pressure value satisfying 80% or less of the pressure baseline as the final position T3n_end of relaxation pressure (wave), thereby obtaining the relaxation time T of upper esophageal sphincter at the time of swallowing relax n=t3n_end-t3n_start and percentage of residual pressure at swallowing P Remainder of the process n＝(PRestn-P3n)/PRestn*100％，P Restn Resting esophageal sphincter pressure for the nth swallow;
and respectively calculating the time difference between the starting time of the pressure of the tongue root and the starting time of the pressure of the hypopharynx region and the starting time of the swallowing pressure of the upper esophageal sphincter, the time difference between the starting time of the pressure of the tongue root and the pressure of the hypopharynx region and the lowest point of the swallowing pressure of the upper esophageal sphincter, and the time difference between the starting time of the pressure of the tongue root and the pressure of the lower pharyngeal region and the ending time of the swallowing pressure of the upper esophageal sphincter by combining the pressure wave characteristics of the tongue root and the upper esophageal sphincter.
As a further preferable technical scheme of the technical scheme, the pressure measuring catheter is provided with N pressure sensors, the distance between every two adjacent pressure sensors is m, the unit is millimeter, continuous pressure measuring data of a channel are output from the measuring position of each pressure sensor, the effective pressure measuring length range of the pressure measuring catheter is larger than the pressure measuring range of the human pharynx and the upper esophageal sphincter group, so that the pressure measuring catheter covers the pressure data which can be acquired by the human pharynx and the upper esophageal sphincter group when the human pharynx and the upper esophageal sphincter group are swallowed in a trial meal, the data sampling module is connected with the pressure measuring catheter which is placed at the positions of the human pharynx and the upper esophageal sphincter for data sampling and storage, and when the human pharynx and the upper esophageal sphincter are inspected, one (5 ml) swallow (of a subject is needed) is carried out every other preset time (1 minute) (and a word such as wet pharynx 5ml is marked here) until N times of swallow are completed.
As a further preferable technical aspect of the above technical aspect, the pressure curve image is a graph in which pressure data sampled by each channel is connected by linearity to present a pressure curve and data fluctuation is observed through the linear pressure curve;
the pressure high-fraction cloud image is obtained by linearly interpolating between adjacent channels by taking the minimum pixel as a unit in each channel data, then obtaining a pressure value set of each pixel point through linear interpolation, searching RGB color values of corresponding pressure in each pressure value set and a predefined pressure color band mapping set table, and replacing the obtained RGB color values with the current pressure value to present a pressure cloud image.
In order to achieve the above object, the present invention also provides an electronic device, including a memory, a processor, and a computer program stored on the memory and executable on the processor, wherein the processor implements the pressure recognition system for human pharynx and upper esophageal sphincter when executing the program.
To achieve the above object, the present invention also provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements the pressure identification system for the human pharynx and upper esophageal sphincter.
Drawings
FIG. 1 is a schematic flow chart of a pressure identification system for the pharyngeal portion and the upper esophageal sphincter of a human body according to the invention.
Figure 2 is a schematic diagram of the location of a pressure identification system for the pharynx and upper esophageal sphincter of a human body according to the invention.
Figure 3 is a high resolution cloud image of upper esophageal sphincter pressure measurements of a pressure identification system for the human pharynx and upper esophageal sphincter of the present invention.
Fig. 4 is a schematic diagram of the pressure of the jaw pharyngeal, tongue root and hypopharynx muscle area and the upper esophageal sphincter of a human body for a pressure identification system of the invention for the pharyngeal and upper esophageal sphincters.
Detailed Description
The following description is presented to enable one of ordinary skill in the art to make and use the invention. The preferred embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art. The basic principles of the invention defined in the following description may be applied to other embodiments, variations, modifications, equivalents, and other technical solutions without departing from the spirit and scope of the invention.
In a preferred embodiment of the invention, it should be noted by those skilled in the art that the pressure catheter and the like to which the invention relates may be regarded as prior art.
Preferred embodiments.
As shown in fig. 1-4, the invention discloses a pressure recognition system for human pharynx and upper esophageal sphincter, which comprises a data sampling module, a data display module and a data analysis module, wherein:
the data sampling module samples pressure data of the pharyngeal portion and the upper esophageal sphincter of a human body through a pressure measuring catheter (comprising a water perfusion pressure measuring catheter and a solid pressure measuring catheter) so as to obtain corresponding pressure data and transmit the corresponding pressure data to the data display module;
the data display module processes and converts the received pressure data into display data comprising a pressure curve image and a pressure high-fraction cloud image;
the data analysis module automatically analyzes the stored display data so as to respectively acquire pressure information including jaw pharyngeal muscles, tongue roots, hypopharynx areas and upper esophageal sphincter.
Specifically, the automatic data analysis of the data analysis module is implemented as follows:
determination of the pressure channel of the upper esophageal sphincter: in the data analysis module, a virtual analysis frame is set forward at the time beginning of the marking range (one marking corresponds to one frame, such as 'resting pressure', '5 ml swallowing', and the like, each marking frame has a starting position and a stopping position) and the time width is set to be T1, the area of the pressure curve (obtained from a pressure linear graph) of each channel (the pressure channel corresponding to a sensor) is averaged within the time width of T1, and the maximum integrated average channel is identified as the central channel C of the upper esophageal sphincter pressure channel ues At the same time calculate the resting pressure P of the upper esophageal sphincter Rest Average value P of pressure ave And baseline P base (baseline is the line segment that is the starting standard in the measurement, where the pressure data for a certain period of time is taken for the central channel and the standard deviation of this pressure data is calculated, when the standard deviation is > 1.0, the data segment is gradually removed from the pressure average P ave The absolute value of the removed pressure data is greater than the standard deviation, then the standard deviation of the removed pressure data is recalculated until the standard deviation is less than 1.0, the average value of the segment of data is taken as a baseline value), the starting position and the ending position of the upper esophageal sphincter pressure are calculated according to the baseline value of 80% on the upper and lower adjacent channels (nearby) through the peak of the central point of the upper esophageal sphincter, and the channel range of the upper esophageal sphincter is determined (such as C ues As the center point, the channel covered by the sphincter meets C ues -1 or C ues +1 on the channel meets the above baseline value);
relaxation time determination at upper esophageal sphincter deglutition: the relaxation time window of the upper esophageal sphincter during swallowing refers to the time that the pressure of the channel is reduced and the pressure low point is continuously maintained during swallowing, the pressure is reduced during swallowing of the central channel of the upper esophageal sphincter, the lowest point of the pressure which is continuously reduced is found, and the previous time is searched (left searching) until the current pressure point meets P base * (1-0.2), the current time point being the onset of relaxation patency upon swallowing of the upper esophageal sphincter, labeled TCln; looking up at a later time (looking up to the right) until the current pressure point meets P base * (1-0.2), the current time point being the end of relaxation patency time when the upper esophageal sphincter swallows, labeled TC2n; the duration of this swallowing upper esophageal sphincter relaxes is g=tc2n-TC 1n, n being identified as the nth swallowing signature;
determination of the jaw pharyngeal pressure channel and maximum pressure value and duration: the jaw pharyngeal pressure channel is determined by subtracting S1cm (preferably 8 cm) from the distance of the central channel of the upper esophageal sphincter, which is the jaw pharyngeal pressure analysis channel C1; finding out that the current peak point pressure of the jaw pharyngeal muscle pressure is F in the range of the esophageal sphincter swallowing relaxation time window Gn C1 Determining a peak value point C1T1n of the jaw pharyngeal muscle pressure, searching in the prior time, and determining a starting point C1TS1n of the jaw pharyngeal muscle pressure according to the fact that the current pressure value meets the current channel baseline (1+0.2); then searching for the following time, and determining a jaw pharyngeal muscle pressure end point C1TS2n according to the fact that the current pressure value meets the current channel baseline (1+0.2); the duration of the pressure of the pharyngeal muscle of the swallowing jaw is C1 Fn =c1ts2n—c1ts1n, n identified as the nth swallowing signature;
determination of tongue root and hypopharynx region pressure channel and maximum pressure value and duration of pressure: the tongue root and hypopharynx region pressure channel is determined by subtracting S2cm (preferably 5 cm) from the upper esophageal sphincter central channel distance, which is the tongue root and hypopharynx region pressure analysis channel C2; finding out the peak pressure of the pressure peak points of the current tongue root and hypopharynx muscle area as F in the range of the upper esophageal sphincter swallowing relaxation time window Gn C2 Determining a peak point C2T1n of the pressure of the tongue root and the hypopharynx region, searching in the prior time, and determining a starting point C2TS1n of the pressure of the tongue root and the hypopharynx region according to the fact that the current pressure value meets the current channel base line (1+0.2); then searching for the time after the time, and determining the pressure end points C2TS2n of the tongue root and the hypopharynx region according to the fact that the current pressure value meets the current channel baseline (1+0.2); the duration of the pressure of the swallow tongue root and the hypopharynx is C2 Fn =c2ts 2n-C2TS1n, n identified as the nth swallowing signature;
after the pressure analysis channels corresponding to the jaw pharyngeal muscles, the tongue root and the hypopharynx regions are determined, pressure changes generated when the jaw pharyngeal muscles, the tongue root and the hypopharynx regions are swallowed are sequentially analyzed within the marking time range of each marking as upper esophageal sphincter pressure measurement, so that corresponding pressure information is obtained.
More specifically, the pressure information for the jaw pharyngeal muscles and the tongue root and hypopharynx regions is embodied as:
obtaining peak time C1T1n and position S1n when the jaw pharyngeal muscles swallow, obtaining peak time C2T1n and position S2n when the tongue root and hypopharynx regions swallow, and calculating an initial speed Vn= (S2 n-S1 n)/(C2T 1n-C1T1 n), wherein n is a swallowing mark number, and the numbers are sequentially numbered from n=1, 2,3.
Obtaining peak value P1n of the swallowing of the jaw pharyngeal muscle, wherein the corresponding peak time is C1T1n; obtaining peak value P2n of the swallowing time (pressure) of the tongue root and the hypopharynx region, wherein the corresponding peak value time is C2T2n; wherein n is the swallowing indicia number described above;
searching forward at the peak value P1n of the jaw pharyngeal muscle, setting a point with the pressure meeting the current channel baseline of 120 percent (jaw pharyngeal muscle pressure) as a starting position T1n_start of a jaw pharyngeal muscle pressure wave, searching forward after the peak value P1n of the jaw pharyngeal muscle, and setting a point with the pressure meeting the current channel baseline of 120 percent as an ending position T1n_end of the pressure wave; and the starting position t2n_start and ending position t2n_end of the pressure wave of the tongue root and hypopharynx region channels are calculated in the same manner; respectively calculating rising edge rate V of swallowing of jaw pharyngeal muscles Upper part n=p1n/(t1n_end-t1n_start), rising edge rate V of swallowing of tongue root and hypopharynx region Upper part n=p2n/(t2n_start-t2n_end); then, respectively calculating the time P1Tn=T1n-T1n_start of reaching the peak value when the jaw pharyngeal muscles swallow, and the time P2Tn=T2n-T2n_start of reaching the peak value when the tongue root and the hypopharynx muscles swallow; the pressure duration at the time of swallowing of the jaw pharyngeal muscles p1ctn=t1n_end-t1n_start, and the pressure duration at the time of swallowing of the tongue root and the hypopharynx region p2ctn=t2n_end-t2n_start were calculated, respectively.
Further, the central channel C of the upper esophageal sphincter is defined ues The lowest pressure point, which is the lowest relaxation pressure T3n of the Upper Esophageal Sphincter (UES) when swallowing, will then be searched in the swallowing frame (the virtual analysis frame is not visible in the figure, and is virtually displayed in a certain range on the left side of the swallowing frame), and the pressure value is P3n, wherein n is the swallowing mark numberThe following analysis was performed in conjunction with the tongue root and hypopharynx region pressure channels:
pressure baseline P through the central point of the upper esophageal sphincter base Retrieving forward at the lowest pressure of relaxation T3n at the time of swallowing the upper esophageal sphincter, taking the point with the pressure value satisfying 80% or less of the pressure baseline as the initial position T3n_start of relaxation pressure (wave), retrieving backward at the lowest pressure of relaxation T3n at the time of swallowing the upper esophageal sphincter, taking the point with the pressure value satisfying 80% or less of the pressure baseline as the final position T3n_end of relaxation pressure (wave), thereby obtaining the relaxation time T of upper esophageal sphincter at the time of swallowing relax n=t3n_end-t3n_start and percentage of residual pressure at swallowing P Remainder of the process n＝(PRestn-P3n)/PRestn*100％，P Restn Resting esophageal sphincter pressure for the nth swallow;
and respectively calculating the time difference between the starting time of the pressure of the tongue root and the starting time of the pressure of the hypopharynx region and the starting time of the swallowing pressure of the upper esophageal sphincter, the time difference between the starting time of the pressure of the tongue root and the pressure of the hypopharynx region and the lowest point of the swallowing pressure of the upper esophageal sphincter, and the time difference between the starting time of the pressure of the tongue root and the pressure of the lower pharyngeal region and the ending time of the swallowing pressure of the upper esophageal sphincter by combining the pressure wave characteristics of the tongue root and the upper esophageal sphincter.
Furthermore, the pressure measuring catheter is provided with N pressure sensors, the distance between every two adjacent pressure sensors is m, the unit is millimeter, continuous pressure measuring data of a channel are output from the measuring position of each pressure sensor, the effective pressure measuring length range of the pressure measuring catheter is larger than the pressure measuring range of the human pharynx and the upper esophageal sphincter group so as to meet the pressure data which can be acquired when the pressure measuring catheter covers the human pharynx and the upper esophageal sphincter group and is in trial swallowing, the data sampling module is connected with the pressure measuring catheter which is placed at the positions of the pharynx and the upper esophageal sphincter of the human body, data sampling and storage are carried out, and when the pharynx and the upper esophageal sphincter of the human body are in trial swallowing, one (5 ml) swallowing (a word such as 'wet pharynx 5 ml' is needed) is carried out until N times of swallowing are finished (the number of the pressure sensors on the catheter is larger, the higher the accuracy is, and the N times of swallowing are each time of trial swallowing is carried out in the process of 5ml of water, and the time interval between each time of swallowing is 20 seconds.
Preferably, the pressure curve image is obtained by connecting pressure data sampled for each channel linearly to present a pressure curve and observing data fluctuations through the linear pressure curve;
the pressure high-fraction cloud image is obtained by linearly interpolating between adjacent channels by taking the minimum pixel as a unit in each channel data, then obtaining a pressure value set of each pixel point through linear interpolation, searching RGB color values of corresponding pressure in each pressure value set and a predefined pressure color band mapping set table, and replacing the obtained RGB color values with the current pressure value to present a pressure cloud image.
The invention also discloses an electronic device, which comprises a memory, a processor and a computer program stored on the memory and capable of running on the processor, wherein the pressure identification system for the pharyngeal portion and the upper esophageal sphincter of the human body is realized when the processor executes the program.
The invention also discloses a non-transitory computer readable storage medium, on which a computer program is stored, which when executed by a processor implements the pressure identification system for the pharynx and upper esophageal sphincter of the human body.
Preferably, for obtaining a pressure cloud or curvilinear pressure map of the upper esophageal sphincter swallowing frame; determining the front preset time (preferably 5 seconds) of the upper esophageal sphincter swallowing frame according to the determined upper esophageal sphincter swallowing frame, acquiring a pharyngeal and upper esophageal sphincter resting pressure cloud picture, and analyzing the upper esophageal sphincter resting pressure; according to the maximum pressure peak of the jaw pharynx formed when the upper esophageal sphincter swallowing frame is swallowed upwards according to the pharynx; determining the contraction pressure peak value of the tongue root and the hypopharynx muscle area and the contraction duration time of the tongue root and the hypopharynx muscle area according to the identified maximum jaw pharyngeal pressure channel and the upper esophageal sphincter pressure channel; the upper esophageal sphincter channel recognizes the maximum peak of upper esophageal sphincter contraction after swallowing and decreases the residual stress of relaxation, the duration of relaxation, etc.
The explanation for the correlation value is:
the average resting pressure of the upper esophageal sphincter, wherein the resting pressure selects the average pressure value of the central channel of the upper esophageal sphincter in the region;
residual relaxation pressure (mmHg), minimum pressure of the central upper esophageal sphincter channel for the duration of relaxation;
relaxation duration (ms), the time taken for the relaxation pressure of the central channel of the upper esophageal sphincter to drop to less than the resting pressure and start timing until the pressure rises and returns to the resting pressure;
the relaxation time reaches the lowest point, and the upper esophageal sphincter central channel pressure is counted from the beginning of relaxation until the time taken for the pressure to drop to the minimum pressure within the duration of relaxation;
recovery time (ms), i.e., relaxation recovery time;
the material morphology and number of swallows were analyzed.
Pharyngeal/upper esophageal sphincter dynamic analysis, statistics were performed by mean.
1. Initial velocities (horizontal wave velocity in cm/s) of 5.0cm and 8.0cm above the upper esophageal sphincter; the distance/time interval between the peaks 5cm and 8cm above the center of the upper esophageal sphincter.
2. Percentage of peristaltic times;
the peristaltic frequency between the peak values of 5cm and 8cm above the center of the upper esophageal sphincter is less than or equal to 25cm/s, and the peristaltic frequency is the percentage of the total peristaltic frequency.
3. Peak pressure 8.0cm above the center of the upper esophageal sphincter (single pass); the highest pressure point value measured 8.0cm above the center of the upper esophageal sphincter (unit: mmHg);
4. peak pressure 5.0cm above the center of the upper esophageal sphincter (single pass); the highest pressure point value measured 5.0cm above the center of the upper esophageal sphincter (unit: mmHg);
5. an ascending velocity (single pass) 8.0cm above the center of the upper esophageal sphincter; a rate of peak pressure/rise time (in mmHg/s) 8.0cm above the center of the upper esophageal sphincter;
6. an ascending velocity (single pass) 5.0cm above the center of the upper esophageal sphincter; a rate of peak pressure/rise time (in mmHg/s) 5.0cm above the center of the upper esophageal sphincter;
7. a rise time of 8.0cm above the center of the upper esophageal sphincter; the time interval (in milliseconds) from just above the upper esophageal sphincter center by 8.0cm of pressure to the systolic peak pressure;
8. a rise time of 5.0cm above the center of the upper esophageal sphincter; the time interval (in milliseconds) from just above 5.0cm above the center of the upper esophageal sphincter to the systolic peak pressure;
9. recovery time 8.0cm above the center of the upper esophageal sphincter;
time interval (in milliseconds) from 8.0cm peak pressure above the center of the upper esophageal sphincter to end of time interval constriction;
10. a recovery time of 5.0cm above the center of the upper esophageal sphincter;
time interval (in milliseconds) from 5.0cm peak pressure above the center of the upper esophageal sphincter to end of time interval constriction;
11. a duration of contraction 8.0cm above the center of the upper esophageal sphincter; 8.0cm above the center of the upper esophageal sphincter, rise time + recovery time (in milliseconds);
12. a duration of contraction of 5.0cm above the center of the upper esophageal sphincter; 5.0cm above the center of the upper esophageal sphincter, rise time + recovery time (units: milliseconds)
13. Starting 5.0cm above the center of the upper esophageal sphincter to the start of the upper esophageal sphincter; calculating from the immediately above 5.0cm pressure above the center of the upper esophageal sphincter, and starting the relaxation time interval (unit: milliseconds) of the upper esophageal sphincter;
14. starting 5.0cm above the center of the upper esophageal sphincter to the lowest point of the upper esophageal sphincter; calculating from the immediately above 5.0cm pressure above the center of the upper esophageal sphincter, the time interval (in milliseconds) from the upper esophageal sphincter to the lowest pressure point;
15. starting 5.0cm above the center of the upper esophageal sphincter and ending the upper esophageal sphincter; the time interval (in milliseconds) from the beginning of relaxation of the upper esophageal sphincter, calculated from just 5.0cm above the center of the upper esophageal sphincter.
For the present invention:
data sampling is carried out through a data sampling module, and UES pressure measurement marking is carried out on the sampled data;
analyzing the data through a data analysis module to determine the marking position and the central position of the residual pressure of the upper esophageal sphincter, which is 8cm above the upper esophageal sphincter and 5cm above the upper esophageal sphincter;
calculating the peak value measured 8.0cm above the center of the upper esophageal sphincter, namely the highest pressure point value (unit: mmHg);
calculating the peak value measured 5.0cm above the center of the upper esophageal sphincter, namely the highest pressure point value (unit: mmHg);
calculating the horizontal wave velocity from the 8cm peak position above the upper esophageal sphincter to the 5cm peak position above the upper esophageal sphincter, displaying the 8cm peak position above the upper esophageal sphincter and the 5cm peak position above the upper esophageal sphincter in a cloud picture, marking by a circle, connecting two points, displaying the value of the horizontal wave velocity, and displaying the value of the horizontal wave velocity in units of cm/s, wherein the unit is shown in figure 4;
the percentage of peristaltic times was calculated. The peristaltic frequency between the peak values of 5cm and 8cm above the center of the upper esophageal sphincter is less than or equal to 25cm/s, and the peristaltic frequency is the percentage of the total peristaltic frequency;
calculating the ascending speed (single channel) 8.0cm above the center of the upper esophageal sphincter;
a rate of peak pressure/rise time (in mmHg/s) 8.0cm above the center of the upper esophageal sphincter;
calculating the ascending speed (single channel) 5.0cm above the center of the upper esophageal sphincter;
a rate of peak pressure/rise time (in mmHg/s) 5.0cm above the center of the upper esophageal sphincter;
calculating the ascending time 8.0cm above the center of the upper esophageal sphincter;
the time interval (in milliseconds) from just above the upper esophageal sphincter center by 8.0cm of pressure to the systolic peak pressure;
calculating the rise time of 5.0cm above the center of the upper esophageal sphincter;
the time interval (in milliseconds) from just above 5.0cm above the center of the upper esophageal sphincter to the systolic peak pressure;
calculating the recovery time 8.0cm above the center of the upper esophageal sphincter;
time interval (in milliseconds) from 8.0cm peak pressure above the center of the upper esophageal sphincter to end of time interval constriction;
calculating the recovery time 5.0cm above the center of the upper esophageal sphincter;
time interval (in milliseconds) from 5.0cm peak pressure above the center of the upper esophageal sphincter to end of time interval constriction;
calculating the contraction duration 8.0cm above the center of the upper esophageal sphincter;
8.0cm above the center of the upper esophageal sphincter, rise time + recovery time (in milliseconds);
calculating a contraction duration of 5.0cm above the center of the upper esophageal sphincter;
5.0cm above the center of the upper esophageal sphincter, rise time + recovery time (units: milliseconds)
Calculating the initiation 5.0cm above the center of the upper esophageal sphincter to the initiation of the upper esophageal sphincter;
calculating from the immediately above 5.0cm pressure above the center of the upper esophageal sphincter, and starting the relaxation time interval (unit: milliseconds) of the upper esophageal sphincter;
calculating the initial position 5.0cm above the center of the upper esophageal sphincter to the lowest point of the upper esophageal sphincter;
calculating from the immediately above 5.0cm pressure above the center of the upper esophageal sphincter, the time interval (in milliseconds) from the upper esophageal sphincter to the lowest pressure point;
calculating the beginning 5.0cm above the center of the upper esophageal sphincter and the end of the upper esophageal sphincter;
the time interval (in milliseconds) from the beginning of relaxation of the upper esophageal sphincter, calculated from just 5.0cm above the center of the upper esophageal sphincter.
It should be noted that technical features such as the pressure measuring catheter related to the present application should be regarded as the prior art, and specific structures, working principles, and control modes and spatial arrangement modes possibly related to the technical features should be selected conventionally in the art, and should not be regarded as the invention point of the present application, and the present application is not further specifically developed in detail.
Modifications of the embodiments described above, or equivalents of some of the features may be made by those skilled in the art, and any modifications, equivalents, improvements or etc. within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (8)
1. The utility model provides a pressure identification system for human pharynx and upper esophageal sphincter, its characterized in that includes data sampling module, data display module and data analysis module, wherein:
the data sampling module samples pressure data of the pharyngeal portion and the upper esophageal sphincter of the human body through the pressure measuring catheter so as to obtain corresponding pressure data and transmit the corresponding pressure data to the data display module;
the data display module processes and converts the received pressure data into display data comprising a pressure curve image and a pressure high-fraction cloud image;
the data analysis module automatically analyzes the stored display data so as to respectively acquire pressure information including jaw pharyngeal muscles, tongue roots, hypopharynx areas and upper esophageal sphincter.
2. The pressure recognition system for the pharynx and the upper esophageal sphincter of the human body according to claim 1, wherein the automatic data analysis of the data analysis module is implemented as follows:
determination of the pressure channel of the upper esophageal sphincter: in the data analysis module, a virtual analysis frame is set forward at the beginning of the time when the first marker range is found in the obtained display data, the time width is set to be T1, the integral mean value is calculated for the area of each channel pressure curve within the time width of T1, and the channel with the maximum integral mean value is confirmed as the upper oneEsophageal sphincter pressure channel center channel C ues At the same time calculate the resting pressure P of the upper esophageal sphincter Rest Average value P of pressure ave And baseline P base Calculating the starting position and the ending position of the upper esophageal sphincter pressure by the upper esophageal sphincter central point peak value and the upper and lower adjacent channels according to the base line by 80%, thereby determining the upper esophageal sphincter channel range;
relaxation time determination at upper esophageal sphincter deglutition: the relaxation time window of the upper esophageal sphincter during swallowing refers to the time when the pressure of the channel is reduced and the pressure low point is continuously maintained during swallowing, the pressure is reduced during swallowing of the central channel of the upper esophageal sphincter, the lowest point of the continuously reduced pressure is found, and the previous time is searched until the current pressure point meets P base * (1-0.2), the current time point being the onset of relaxation patency upon swallowing of the upper esophageal sphincter, labeled TC1n; searching at a later time until the current pressure point meets P base * (1-0.2), the current time point being the end of relaxation patency time when the upper esophageal sphincter swallows, labeled TC2n; the last esophageal sphincter relaxes this time swallow for a duration of gn=tc2n-TC 1n, n identified as the nth swallowing indicia;
determination of the jaw pharyngeal pressure channel and maximum pressure value and duration: the jaw pharyngeal pressure channel is obtained by subtracting S1cm from the distance of the central channel of the upper esophageal sphincter, wherein the position is a jaw pharyngeal pressure analysis channel C1; finding out that the current peak point pressure of the jaw pharyngeal muscle pressure is F in the range of the esophageal sphincter swallowing relaxation time window Gn C1 Determining a peak value point C1T1n of the jaw pharyngeal muscle pressure, searching in the prior time, and determining a starting point C1TS1n of the jaw pharyngeal muscle pressure according to the fact that the current pressure value meets the current channel baseline (1+0.2); then searching for the following time, and determining a jaw pharyngeal muscle pressure end point C1TS2n according to the fact that the current pressure value meets the current channel baseline (1+0.2); the duration of the swallowing jaw pharyngeal muscle pressure is C1Fn=C1TS 2n-C1TS1n, and n is marked as an nth swallowing mark;
determination of tongue root and hypopharynx region pressure channel and maximum pressure value and duration of pressure: the pressure channel of the tongue root and hypopharyngeal muscle zone was subtracted by S2cm in determining the upper esophageal sphincter central channel distance, theThe position is a tongue root and hypopharynx region pressure analysis channel C2; finding out the peak pressure of the pressure peak points of the current tongue root and hypopharynx muscle area as F in the range of the upper esophageal sphincter swallowing relaxation time window Gn C2 Determining a peak point C2T1n of the pressure of the tongue root and the hypopharynx region, searching in the prior time, and determining a starting point C2TS1n of the pressure of the tongue root and the hypopharynx region according to the fact that the current pressure value meets the current channel base line (1+0.2); then searching for the time after the time, and determining the pressure end points C2TS2n of the tongue root and the hypopharynx region according to the fact that the current pressure value meets the current channel baseline (1+0.2); the duration of the pressure of the swallowing tongue root and the hypopharynx muscle area is C2Fn=C2TS 2n-C2TS1n, and n is marked as an nth swallowing mark;
after the pressure analysis channels corresponding to the jaw pharyngeal muscles, the tongue root and the hypopharynx regions are determined, pressure changes generated when the jaw pharyngeal muscles, the tongue root and the hypopharynx regions are swallowed are sequentially analyzed within the marking time range of each marking as upper esophageal sphincter pressure measurement, so that corresponding pressure information is obtained.
3. The pressure recognition system for the pharyngeal portion and the upper esophageal sphincter of the human body according to claim 2, wherein the pressure information for the jaw pharyngeal muscles and the tongue root and hypopharynx regions is embodied as:
obtaining peak time C1T1n and position S1n when the jaw pharyngeal muscles swallow, obtaining peak time C2T1n and position S2n when the tongue root and hypopharynx regions swallow, and calculating an initial speed Vn= (S2 n-S1 n)/(C2T 1n-C1T1 n), wherein n is a swallowing mark number, and the numbers are sequentially numbered from n=1, 2,3.
Obtaining peak value P1n of the swallowing of the jaw pharyngeal muscle, wherein the corresponding peak value time is C1T1n; obtaining peak value P2n of the swallow of the tongue root and the hypopharyngeal muscle region, wherein the corresponding peak value time is C2T2n; wherein n is the swallowing indicia number described above;
searching forward at the peak value P1n of the jaw pharyngeal muscle, setting a point with the pressure meeting the current channel baseline of 120% as a starting position T1n_start of a jaw pharyngeal muscle pressure wave, searching forward after the peak value P1n of the jaw pharyngeal muscle, and setting a point with the pressure meeting the current channel baseline of 120% as an ending position T1n_end of the pressure wave; and the tongue root and hypopharynx are calculated in the same mannerA start position t2n_start and an end position t2n_end of the pressure wave of the muscular channel; respectively calculating rising edge rate V of swallowing of jaw pharyngeal muscles Upper part n=p1n/(t1n_end-t1n_start), rising edge rate V of swallowing of tongue root and hypopharynx region Upper part n=p2n/(t2n_start-t2n_end); then, respectively calculating the time P1Tn=T1n-T1n_start of reaching the peak value when the jaw pharyngeal muscles swallow, and the time P2Tn=T2n-T2n_start of reaching the peak value when the tongue root and the hypopharynx muscles swallow; the pressure duration at the time of swallowing of the jaw pharyngeal muscles p1ctn=t1n_end-t1n_start, and the pressure duration at the time of swallowing of the tongue root and the hypopharynx region p2ctn=t2n_end-t2n_start were calculated, respectively.
4. A pressure recognition system for the pharynx and upper esophageal sphincter of a human body as claimed in claim 3, wherein the central passage C of the upper esophageal sphincter is defined ues The lowest pressure point will then be retrieved in the swallowing frame as the lowest pressure relaxation point T3n at the time of swallowing by the upper esophageal sphincter, with a pressure value of P3n, where n is the swallowing indicia number described above, and the following analysis will be performed in conjunction with the tongue root and hypopharyngeal muscle zone pressure channels:
pressure baseline P through the central point of the upper esophageal sphincter base Retrieving forward at the lowest relaxed pressure point T3n when the upper esophageal sphincter swallows, taking the point with the pressure value less than or equal to 80% of the pressure baseline as a relaxed pressure starting position T3n_start, retrieving backward at the lowest relaxed pressure point T3n when the upper esophageal sphincter swallows, and taking the point with the pressure value less than or equal to 80% of the pressure baseline as a relaxed pressure ending position T3n_end, thereby obtaining the relaxed time T of the upper esophageal sphincter when swallowing relax n=t3n_end-t3n_start and percentage of residual pressure at swallowing P Remainder of the process n＝(PRestn-P3n)/PRestn*100％，P Restn Resting esophageal sphincter pressure for the nth swallow;
and respectively calculating the time difference between the starting time of the pressure of the tongue root and the starting time of the pressure of the hypopharynx region and the starting time of the swallowing pressure of the upper esophageal sphincter, the time difference between the starting time of the pressure of the tongue root and the pressure of the hypopharynx region and the lowest point of the swallowing pressure of the upper esophageal sphincter, and the time difference between the starting time of the pressure of the tongue root and the pressure of the lower pharyngeal region and the ending time of the swallowing pressure of the upper esophageal sphincter by combining the pressure wave characteristics of the tongue root and the upper esophageal sphincter.
5. The pressure recognition system for the human pharynx and the upper esophageal sphincter of claim 4, wherein the pressure measuring catheter is provided with N pressure sensors, the distance between every two adjacent pressure sensors is m, the unit is millimeter, the measuring position of each pressure sensor outputs continuous pressure measuring data of a channel, the effective pressure measuring length range of the pressure measuring catheter is larger than the pressure measuring range of the human pharynx and the upper esophageal sphincter group so as to meet the pressure data which can be acquired when the pressure measuring catheter covers the human pharynx and the upper esophageal sphincter group and is swallowed in trial, the data sampling module is connected with the pressure measuring catheter which is placed on the pharynx and the upper esophageal sphincter of the human body, data sampling and storage are carried out, and swallowing is carried out once every preset time when the pharynx and the upper esophageal sphincter of the human body are inspected until the swallowing is completed for N times.
6. The pressure recognition system for the pharynx and upper esophageal sphincter of human body of claim 5, wherein the pressure curve image is obtained by connecting the pressure data sampled from each channel by linearity to present a pressure curve and observing the data fluctuation through the linear pressure curve;
the pressure high-fraction cloud image is obtained by linearly interpolating between adjacent channels by taking the minimum pixel as a unit in each channel data, then obtaining a pressure value set of each pixel point through linear interpolation, searching RGB color values of corresponding pressure in each pressure value set and a predefined pressure color band mapping set table, and replacing the obtained RGB color values with the current pressure value to present a pressure cloud image.
7. An electronic device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor implements the pressure identification system for the human pharynx and upper esophageal sphincter of any one of claims 1 to 6 when the program is executed by the processor.
8. A non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements a pressure identification system for the human pharynx and upper esophageal sphincter of claim 1 to 6.
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