CN116887679A - Antibacterial iron powder - Google Patents
Antibacterial iron powder Download PDFInfo
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- CN116887679A CN116887679A CN202280017184.5A CN202280017184A CN116887679A CN 116887679 A CN116887679 A CN 116887679A CN 202280017184 A CN202280017184 A CN 202280017184A CN 116887679 A CN116887679 A CN 116887679A
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 176
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 150
- 229910052742 iron Inorganic materials 0.000 claims abstract description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 30
- 229910052717 sulfur Inorganic materials 0.000 claims description 30
- 239000011593 sulfur Substances 0.000 claims description 30
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 27
- 239000010949 copper Substances 0.000 claims description 27
- 229910052802 copper Inorganic materials 0.000 claims description 26
- 239000000843 powder Substances 0.000 claims description 21
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 15
- 229910052698 phosphorus Inorganic materials 0.000 claims description 15
- 239000011574 phosphorus Substances 0.000 claims description 15
- 230000001747 exhibiting effect Effects 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 description 28
- 239000008223 sterile water Substances 0.000 description 18
- 239000000725 suspension Substances 0.000 description 14
- 241000588724 Escherichia coli Species 0.000 description 12
- 241000191967 Staphylococcus aureus Species 0.000 description 12
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 11
- 229910001448 ferrous ion Inorganic materials 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 239000002245 particle Substances 0.000 description 8
- 238000010828 elution Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000011081 inoculation Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- -1 silver ions Chemical class 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 241000221535 Pucciniales Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000005275 alloying Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000010954 inorganic particle Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 1
- 239000005751 Copper oxide Substances 0.000 description 1
- 229910000881 Cu alloy Inorganic materials 0.000 description 1
- 229910000640 Fe alloy Inorganic materials 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000004566 building material Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000011246 composite particle Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000009689 gas atomisation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002506 iron compounds Chemical class 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000009692 water atomization Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The purpose of the present invention is to provide an iron powder for antibacterial use which is inexpensive and has excellent antibacterial activity. The iron powder for antibacterial use according to one embodiment of the present invention contains metallic iron as a main component.
Description
Technical Field
The present invention relates to an antibacterial iron powder.
Background
Today, the need for antibacterial substances is increasing due to increased awareness of hygiene and the like. Silver, copper, and the like are known as metals having antibacterial action. For example, patent document 1 proposes an antibacterial composite particle comprising: an antibacterial inorganic particle A having silver or silver ions; antibacterial inorganic particles B containing zinc, titanium, copper or nickel.
Prior art literature
Patent literature
Patent document 1: japanese patent laid-open publication No. 2005-179607
Disclosure of Invention
Problems to be solved by the invention
However, antibacterial metals such as silver and copper, which are widely used at present, have excellent antibacterial action but are expensive. In contrast, the required antimicrobial properties for the articles are not the same. For example, the degree of antibacterial properties required for medical sites and the degree of antibacterial properties required for daily necessities are different. Accordingly, demands for antibacterial substances are increasing nowadays, and thus, not only can the necessary antibacterial action be exerted, but also the manufacturing cost can be suppressed.
The present invention has been made in view of such circumstances, and an object thereof is to provide an iron powder for antibacterial purposes which is inexpensive and has excellent antibacterial action.
Means for solving the problems
The iron powder for antibacterial use according to one embodiment of the present invention contains metallic iron as a main component.
ADVANTAGEOUS EFFECTS OF INVENTION
The iron powder for antibacterial according to one embodiment of the present invention is inexpensive and has excellent antibacterial activity.
Drawings
FIG. 1 is a graph showing the relationship between the elapsed time and the number of viable bacteria of Staphylococcus aureus in No.1 to No. 4.
FIG. 2 is a graph showing the relationship between the elapsed time and the number of viable bacteria of E.coli in Nos. 1 to 4.
FIG. 3 is a graph showing the relationship between the elapsed time and the number of viable bacteria of Staphylococcus aureus in No.16 to No. 21.
FIG. 4 is a graph showing the relationship between the elapsed time and the number of viable bacteria of E.coli in Nos. 16 to 21.
Detailed Description
Description of embodiments of the invention
First, the embodiments of the present invention are described below.
The iron powder for antibacterial use according to one embodiment of the present invention contains metallic iron as a main component.
The iron powder for antibacterial use is inexpensive and has excellent antibacterial action because it contains metallic iron as a main component. Further, since the antibacterial iron powder is a powder, the surface area is large, and even if the surface of the metallic iron rusts, the metallic iron naturally peels off, and new surfaces of the metallic iron continue to be exposed, so that the antibacterial effect is excellent in duration, and the antibacterial iron powder can be easily blended with various products and materials requiring antibacterial properties.
The antibacterial iron powder further contains an antibacterial element, and the antibacterial element may be contained in the metallic iron. In this way, by containing the antibacterial effect-expressing element contained in the metallic iron, the antibacterial effect can be improved.
The antibacterial property-exhibiting element may be sulfur or phosphorus. Thus, the antibacterial effect can be remarkably improved by using sulfur or phosphorus as the antibacterial element.
The sulfur content is preferably 0.02 mass% or more and 5 mass% or less. The content of sulfur in the above range can easily and surely improve the antibacterial effect.
The content of phosphorus is preferably 1% by mass or more and 5% by mass or less. The content of phosphorus in the above range can easily and surely improve the antibacterial effect.
The antibacterial property-imparting element may be copper. The antibacterial effect-expressing element is copper, and the antibacterial effect can be easily and surely improved.
The antibacterial iron powder is water atomized powder. The antibacterial iron powder is water atomized powder, and has a larger specific surface area than that of large-sized materials such as iron plates. As a result, the antibacterial effect is easily and effectively exerted.
In the present invention, the term "main component" means a component having the largest content in terms of mass, and for example, means a component having a content of 50 mass% or more. The "antibacterial property-exhibiting element" includes an element having antibacterial property itself and an element that causes other elements to exhibit antibacterial property by chemical reaction.
[ details of the embodiments of the present invention ]
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. The numerical values described in the present specification may be arbitrarily combined with the upper limit value and the lower limit value. In the present specification, all numerical ranges from the upper limit value to the lower limit value that can be combined are described as suitable ranges.
[ iron powder for antibacterial use ]
The antibacterial iron powder is an iron powder containing metallic iron as a main component. As the metallic iron, pure iron and iron compounds are exemplified. Among them, pure iron is preferable as the metallic iron. The iron powder for antibacterial use is thought to be produced by ferrous ions (Fe 2+ ) Is eluted to exert an antibacterial effect. More specifically, it is considered that ferrous ions are attracted to a prokaryote (bacteria) by electrostatic induction, reduce the cell wall of the prokaryote, penetrate into the cell wall, and then reduce DNA in the cell wall to exert an antibacterial effect. In this case, if the metallic iron contains impurities, the impurities may interfere with elution of ferrous ions. In contrast, the metallic iron is pure iron, and ferrous ions are properly eluted, thereby easily exhibiting a desired antibacterial effect. The lower limit of the pure iron content in the metallic iron is preferably 50 mass%. The content of pure iron is not less than the lower limit, so that the elution amount of ferrous ions can be sufficiently increased, and the antibacterial effect and the durability of the antibacterial effect can be improved. The term "pure iron" means that it is easily obtained for industrial use and has a purity of 90.0 mass% or more.
The lower limit of the average particle diameter of the antibacterial iron powder is preferably 50. Mu.m, more preferably 60. Mu.m. On the other hand, the upper limit of the average particle diameter is preferably 150. Mu.m, more preferably 100. Mu.m. If the average particle diameter is less than the lower limit, the manufacturing cost of the iron powder for antibacterial purposes may increase. Conversely, if the average particle diameter exceeds the upper limit, it is difficult to sufficiently increase the specific surface area of the iron powder for antibacterial purposes, and it may be difficult to sufficiently exert antibacterial action. The term "average particle diameter" means a particle diameter obtained by using JIS-Z8801-1:2019, to obtain a particle size distribution in which a particle size having a mass of 50% is accumulated.
The iron powder for antibacterial use preferably contains an antibacterial-expressing element. The antibacterial effect-imparting element is preferably contained in the metallic iron. The iron powder for antibacterial use can contain the antibacterial effect-exhibiting element in the metallic iron, and can improve the antibacterial effect. In the present invention, the "antimicrobial-expressing element" is distinguished from the "metallic iron" as a separate component.
Examples of the antibacterial effect-imparting element include sulfur (S) and phosphorus (P). The antibacterial iron powder contains sulfur or phosphorus in the metallic iron, and can promote the dissolution of ferrous ions.
When the antibacterial effect-expressing element is sulfur, sulfur itself also contributes to the expression of the antibacterial effect, and thus the antibacterial effect is further improved. In detail, when sulfur is contained in the metallic iron, the transfer of electrons from iron to sulfur can promote elution of ferrous ions. It is considered that, for example, if the iron powder for antibacterial is disposed in a liquid, sulfide ions (S 2－ ) By reacting hydroxide ions (OH) － ) Sulfuric acid (H) 2 SO 4 ) And chemical substances with antibacterial activity occur, and the antibacterial effect is improved.
When the antibacterial element is sulfur, the lower limit of the sulfur content in the iron powder for antibacterial is preferably 0.02 mass%, more preferably 0.3 mass%, and even more preferably 0.5 mass%. On the other hand, the upper limit of the content is preferably 5% by mass, more preferably 3% by mass, and still more preferably 2% by mass. If the content is less than the lower limit, it may be difficult to exert the desired antibacterial property-improving effect. Conversely, if the content exceeds the upper limit, blending of sulfur into the iron powder for antibacterial purposes is difficult, and the production cost may be excessively increased with respect to the effect of improving the antibacterial effect.
When the antibacterial effect-imparting element is phosphorus, the lower limit of the phosphorus content in the iron powder for antibacterial is preferably 1 mass%, more preferably 1.5 mass%, and even more preferably 2 mass%. On the other hand, the upper limit of the content is preferably 5% by mass, more preferably 4% by mass, and still more preferably 3% by mass. If the content is less than the lower limit, it may be difficult to exert the desired antibacterial property-improving effect. Conversely, if the content exceeds the upper limit, phosphorus may be blended into the iron powder for antibacterial purposes, and the production cost may be excessively increased with respect to the effect of improving the antibacterial effect.
The antibacterial property-imparting element may be copper. Copper is known to have an antibacterial effect, and conventionally, a single component (copper alone) thereof has been used or a mixed powder as described in patent document 1 has been used. In contrast, in the iron powder for antibacterial use, copper is alloyed with iron. In this iron powder for antibacterial use, it is considered that copper having a low ionization tendency is difficult to dissolve ions relative to iron, and on the other hand, copper and iron alloy exhibit characteristics different from those of copper monomers or iron monomers by interaction such as local battery reaction. In other words, the iron powder for antibacterial is based on the novel finding that the antibacterial activity of iron is activated by alloying copper with iron, instead of focusing on the antibacterial activity of copper itself. The antibacterial iron powder is considered to be easily exfoliated because it is mainly iron, though an oxide film can be formed on the surface of the antibacterial iron powder, unlike a copper oxide film formed on the surface of a copper single body. As a result, since part of the new surface of iron continues to be exposed, it is estimated that the antibacterial property is likely to be continuously developed. In addition, in the iron powder for antibacterial purposes, alloying copper with iron makes it easier to suppress the manufacturing cost at a lower level than an antibacterial material of copper alone.
When the antibacterial element is copper, the lower limit of the copper content in the iron powder for antibacterial is preferably 2% by mass, more preferably 3% by mass, and even more preferably 4% by mass. On the other hand, the upper limit of the content is preferably 10 mass%, more preferably 8 mass%, and even more preferably 6 mass%. If the content is less than the lower limit, it may be difficult to exert the desired antibacterial property-improving effect. Conversely, if the content exceeds the upper limit, the blending of copper into the iron powder for antibacterial purposes is difficult, and the production cost may be excessively increased with respect to the effect of improving the antibacterial effect.
The method for producing the antibacterial iron powder is not particularly limited. The antibacterial iron powder can be produced by, for example, a reduction method, a gas atomization method, or the like. However, as a method for producing the iron powder for antibacterial use, a water atomization method is preferable. That is, the antibacterial iron powder is preferably a water atomized powder. The water atomized powder is produced by spraying high-pressure water onto molten metallic iron to thereby miniaturize and solidify the metallic iron. The surface of the water atomized powder has irregularities, so that the specific surface area is increased. Therefore, the water atomized powder is excellent in the elution of ferrous ions. The water atomized powder is obtained by adding the antimicrobial element to metallic iron during melting of the metallic iron. Therefore, the water-atomized powder can easily prevent the contamination of impurities (in other words, can selectively contain the antibacterial element), and can easily control the content of the antibacterial element. That is, according to the water atomized powder, the composition of the entire antimicrobial iron powder is easily and surely controlled. Therefore, the antibacterial iron powder is a water-atomized powder, and can promote elution of ferrous ions, thereby allowing an antibacterial effect to be easily and effectively exhibited. In addition, the antibacterial iron powder is water atomized powder, so that the manufacturing cost can be reduced.
The antibacterial iron powder can be blended with products such as sundries, building materials, furniture and the like and materials thereof. That is, the iron powder for antibacterial can be used in products and materials thereof in which bacterial growth is not desired because of hygiene, which can be brought into contact with daily living.
< advantage >
The iron powder for antibacterial use is inexpensive and excellent in antibacterial action because it contains metallic iron as a main component. Further, since the antibacterial iron powder is a powder, the surface area is large, and even if the surface of the metallic iron rusts, the metallic iron is naturally peeled off, and the new surface of the metallic iron is continuously exposed, so that the antibacterial effect is excellent in the durability, and the antibacterial iron powder can be easily blended with various products and materials requiring antibacterial properties.
Other embodiments
The above embodiment is not limited to the configuration of the present invention. Therefore, the above-described embodiments may be omitted, substituted or added to the constituent elements of the above-described embodiments based on the description of the present specification and the technical common knowledge, and these should be interpreted as falling within the scope of the present invention.
For example, if the antibacterial iron powder can exert an antibacterial effect by elution of ferrous ions, the antibacterial performance-imparting element may not be contained.
Examples
The present invention will be described in detail with reference to examples, but the present invention is not limited to the description of the examples.
Test example 1
Preparation of test bacterial liquid
As test bacteria, staphylococcus aureus and Escherichia coli were used, and each test bacteria was inoculated on a common agar medium and cultured at a temperature of 30℃to 35℃for 24 hours. Thereafter, for each test cell, physiological saline was used to obtain a cell count of 10 8 [CFU(Colony Forming Unit)/mL]The preparation method is used for preparing the test bacterial liquid.
< preparation of test sample >
(No. 1 to No. 3)
As a sample, a water atomized powder containing sulfur in a proportion of 1 mass% in pure iron was used. This sample was suspended in sterile water at 1g/L and 10mL was dispensed into a test tube as a test sample No. 1. The sample was suspended in 10g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No.2, and the sample was suspended in 100g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No. 3.
(No.4)
Sterile water without suspending the sample was used as the test sample No. 4.
< calculation of viable count >)
Each of the test samples No.1 to No.4 was inoculated with 0.1mL of the above-mentioned test bacterial liquid, and allowed to stand at 25 ℃. After the inoculation, 1 hour and 4 hours from the inoculation, 10-fold dilution series of the above test samples were prepared with SCDLP liquid medium (lecithin polysorbate 80 added soybean casein digestive liquid medium) to obtain test solutions. These test solutions were inoculated onto SCDLP agar medium and cultured at a temperature of 30℃to 35℃for 72 hours. After this culture, the colonies formed were counted and the number of viable bacteria was counted. With regard to No.1 to No.3, 3 tests were performed, respectively, and the average value in the 3 tests was obtained as the viable count. The results of this calculation are shown in table 1. The viable cell number "0" in table 1 means that no cell was detected by culturing.
[ Table 1]
< evaluation result >
As shown in Table 1 and FIGS. 1 and 2, in the samples No.1 to No.3 containing sulfur in pure iron, the number of viable bacteria of Staphylococcus aureus and Escherichia coli was significantly reduced. This is thought to be because sulfur effectively promotes elution of ferrous ions. As shown in No.4, when Staphylococcus aureus and Escherichia coli are compared, the number of viable bacteria of Staphylococcus aureus increases after 4 hours from inoculation than after 1 hour from inoculation. This is considered to be because individual differences caused by the test species exist as errors when compared with E.coli.
Test example 2
The number of viable bacteria of Staphylococcus aureus and Escherichia coli was calculated by the same procedure as in test example 1, using the samples of the above-mentioned Nos. 1 to 3 and the samples of the following Nos. 8 to 15. In No.1 to No.3 and No.8 to No.15, 3 tests were performed, respectively, and the average value of the 3 tests was obtained as the viable count. In addition, the results of calculation of the viable count of the samples No.1 to No.3 were different in test example 1 and test example 2. This is considered to be an error caused by test bacteria and the like. The results of calculation of the number of viable bacteria are shown in Table 2.
(No. 8 to No. 10)
As a sample, water atomized powder containing sulfur in a proportion of 0.3 mass% in pure iron was used. This sample was suspended in sterile water at 1g/L and 10mL was dispensed into a test tube as a test sample No. 8. The sample was suspended in 10g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No.9, and the sample was suspended in 100g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No. 10.
(No.11)
As a sample, water atomized powder containing sulfur in a proportion of 0.02 mass% in pure iron was used. This sample was suspended in sterile water at 100g/L and 10mL of the suspension was dispensed into a test tube as a test sample No. 11.
(No.12)
As a sample, water atomized powder containing sulfur in a proportion of 0.005 mass% in pure iron was used. This sample was suspended in sterile water at 100g/L and 10mL of the suspension was dispensed into a test tube as a test sample No. 12.
(No. 13 to No. 15)
Glass beads were used as samples. This sample was suspended in sterile water at 1g/L and 10mL of the suspension was dispensed into a test tube as a test sample No. 13. The sample was suspended in 10g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No.14, and the sample was suspended in 100g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No. 15.
[ Table 2]
< evaluation result >
As shown in Table 2, no.1 to No.3, which have sulfur contents of 1% by mass, show a significant reduction in the number of viable bacteria in Staphylococcus aureus and Escherichia coli. In addition, in No.8 to No.11, the sulfur content was 0.02 mass% or more, the number of viable bacteria after 4 hours from inoculation was also reduced from 1 hour from inoculation. In addition, in N.12 having a sulfur content of 0.005 mass%, the number of viable bacteria tends to be smaller than that of the glass beads (N.13 to No. 15) shown in the comparative example. From these results, it is found that the antibacterial iron powder can improve the antibacterial effect by containing sulfur in the metallic iron, and particularly, the reduction effect of the number of living bacteria can be improved by setting the sulfur content to 0.02 mass% or more. This means that sulfur is an important element for exhibiting antibacterial properties.
Test example 3
Test bacterial solutions were prepared in the same manner as in test example 1, and the numbers of live bacteria of Staphylococcus aureus and Escherichia coli were calculated in the same manner as in test example 1 using the samples of Nos. 1 to 3 and the samples of Nos. 16 to 21 described later. The results of calculation of the number of viable bacteria are shown in Table 3. In addition, in test example 1 and test example 3, the results of calculation of the number of viable bacteria of the samples No.1 to No.3 were different. This is considered to be an error caused by test bacteria and the like. The viable cell number "0" in Table 3 means that no cells were detected by culture. The antibacterial effect-expressing element in table 3 means an element that can obtain an antibacterial effect-improving effect by being contained in metallic iron, and the number of viable bacteria in table 3 does not indicate the antibacterial effect caused by the antibacterial effect-expressing element alone.
(No. 16 to No. 18)
As a sample, water atomized powder containing phosphorus in a proportion of 2 mass% in pure iron was used. This sample was suspended in sterile water at 1g/L and 10mL of the suspension was dispensed into a test tube as a test sample No. 16. The sample was suspended in 10g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No.17, and the sample was suspended in 100g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No. 18.
(No. 19 to No. 21)
As a sample, water atomized powder containing copper in a proportion of 5 mass% in pure iron was used. This sample was suspended in sterile water at 1g/L and 10mL was dispensed into a test tube as a test sample No. 19. The sample was suspended in 10g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No.20, and the sample was suspended in 100g/L of the sterile water and 10mL of the suspension was dispensed into a test tube as a test sample No. 21.
[ Table 3]
< evaluation result >
As shown in Table 3, in Nos. 1 to 3, which have sulfur contents of 1% by mass, the number of viable bacteria of Staphylococcus aureus and Escherichia coli were significantly reduced. As shown in table 3 and fig. 3 and 4, in nos. 19 to 21, in which copper was used as an element exhibiting antimicrobial properties, both staphylococcus aureus and escherichia coli were able to confirm a tendency that the number of viable bacteria was greatly reduced. Further, as shown in Table 3 and FIGS. 3 and 4, in No.16 to No.18, in which phosphorus was used as an element exhibiting antimicrobial activity, particularly in No.18, in which the sample was suspended in sterilized water at 100g/L, both Staphylococcus aureus and Escherichia coli were able to confirm a tendency that the number of viable bacteria was slightly decreased. As is clear from this, phosphorus and copper are preferable as the element showing the antibacterial property in the iron powder for antibacterial property, in addition to sulfur.
As shown in table 3 and fig. 3 and 4, the number of viable bacteria in nos. 19 to 21 using copper as the antibacterial effect-expressing element was greatly reduced, and it is considered that the antibacterial effect derived from copper was not reduced by the recombination with metallic iron. From these results, it is clear that the antibacterial iron powder is composed of, for example, an alloy powder containing copper, and can exhibit such antibacterial effect.
Industrial applicability
As described above, the iron powder for antibacterial according to one embodiment of the present invention is inexpensive and excellent in antibacterial action, and therefore can be suitably blended into various products and materials thereof.
Claims (7)
1. An antibacterial iron powder contains metallic iron as main component.
2. The iron powder for antibacterial use according to claim 1, further comprising an antibacterial effect-imparting element,
the antibacterial effect-imparting element is contained in the metallic iron.
3. The iron powder for antibacterial use according to claim 2, wherein the antibacterial effect-imparting element is sulfur or phosphorus.
4. The iron powder for antibacterial use according to claim 3, wherein the element exhibiting antibacterial properties is sulfur, and the sulfur content is 0.02 mass% or more and 5 mass% or less.
5. The iron powder for antibacterial use according to claim 3, wherein the element exhibiting antibacterial properties is phosphorus, and the content of phosphorus is 1 mass% or more and 5 mass% or less.
6. The iron powder for antibacterial use according to claim 2, wherein the element exhibiting antibacterial property is copper.
7. The iron powder for antibacterial use according to any one of claims 1 to 6, wherein the iron powder for antibacterial use is a water atomized powder.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021-061322 | 2021-03-31 | ||
| JP2022005713A JP2022158900A (en) | 2021-03-31 | 2022-01-18 | Antibacterial iron powder |
| JP2022-005713 | 2022-01-18 | ||
| PCT/JP2022/003397 WO2022209243A1 (en) | 2021-03-31 | 2022-01-28 | Antibacterial iron powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116887679A true CN116887679A (en) | 2023-10-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280017184.5A Pending CN116887679A (en) | 2021-03-31 | 2022-01-28 | Antibacterial iron powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116887679A (en) |
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2022
- 2022-01-28 CN CN202280017184.5A patent/CN116887679A/en active Pending
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