CN116849760A - Catheter for thrombolysis and ultrasonic thrombolysis system - Google Patents
Catheter for thrombolysis and ultrasonic thrombolysis system Download PDFInfo
- Publication number
- CN116849760A CN116849760A CN202310862851.6A CN202310862851A CN116849760A CN 116849760 A CN116849760 A CN 116849760A CN 202310862851 A CN202310862851 A CN 202310862851A CN 116849760 A CN116849760 A CN 116849760A
- Authority
- CN
- China
- Prior art keywords
- catheter
- ultrasonic
- drug injection
- cavity
- outer tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002537 thrombolytic effect Effects 0.000 title claims abstract description 82
- 239000003814 drug Substances 0.000 claims abstract description 105
- 238000002347 injection Methods 0.000 claims abstract description 100
- 239000007924 injection Substances 0.000 claims abstract description 100
- 229940079593 drug Drugs 0.000 claims abstract description 97
- 239000000110 cooling liquid Substances 0.000 claims abstract description 33
- 230000026683 transduction Effects 0.000 claims abstract description 15
- 238000010361 transduction Methods 0.000 claims abstract description 15
- 239000003146 anticoagulant agent Substances 0.000 claims description 29
- 208000007536 Thrombosis Diseases 0.000 claims description 18
- 230000007246 mechanism Effects 0.000 claims description 15
- 230000008602 contraction Effects 0.000 claims description 14
- 239000012781 shape memory material Substances 0.000 claims description 8
- 230000004323 axial length Effects 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 2
- 238000002604 ultrasonography Methods 0.000 description 17
- 239000003527 fibrinolytic agent Substances 0.000 description 16
- 239000012809 cooling fluid Substances 0.000 description 10
- 239000012530 fluid Substances 0.000 description 7
- 102000009123 Fibrin Human genes 0.000 description 5
- 108010073385 Fibrin Proteins 0.000 description 5
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229950003499 fibrin Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000009529 body temperature measurement Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 208000010378 Pulmonary Embolism Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 210000001147 pulmonary artery Anatomy 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 210000002073 venous valve Anatomy 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010039163 Right ventricular failure Diseases 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000005242 cardiac chamber Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22027—Features of transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0037—Multi-lumen catheters with stationary elements characterized by lumina being arranged side-by-side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0039—Multi-lumen catheters with stationary elements characterized by lumina being arranged coaxially
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
Abstract
The embodiment of the invention provides a catheter for thrombolysis and an ultrasonic thrombolysis system, which comprises: a catheter body and a drug injection member; a cooling liquid cavity is formed in the catheter main body and is used for accommodating an ultrasonic catheter, the cooling liquid cavity is opened to the outside to form a cooling liquid interface and an accommodating port, the cooling liquid interface is used for injecting cooling liquid into the cooling liquid cavity, and the accommodating port is used for accommodating the ultrasonic catheter; the drug injection piece is arranged at the far end of the catheter main body, a first drug injection cavity is formed on the drug injection piece, a drug injection hole is formed by opening the first drug injection cavity to the outside, a second drug injection cavity is formed on the catheter main body, the second drug injection cavity is communicated with the first drug injection cavity, and a drug injection interface is formed by opening the second drug injection cavity to the outside. The catheter for thrombolysis and the ultrasonic thrombolysis system can avoid the over-high temperature of the ultrasonic transduction component, thereby avoiding the burn of a patient caused by high temperature.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a catheter for thrombolysis and an ultrasonic thrombolysis system.
Background
After thrombus has formed in the venous circulation of the human body, the thrombus typically enters the right heart chamber via the venous circulation and subsequently enters the pulmonary artery, resulting in pulmonary embolism. Pulmonary embolism can lead to right heart failure, reducing blood flow through the lungs, and thus reducing oxygenation of the organ tissue.
At present, interventional thrombolysis is a mainstream mode of vascular embolism treatment. The method includes attempting to clear emboli from pulmonary arteries using anticoagulants and thrombolytics, such as by placing a thrombolytic catheter to administer thrombolytic drugs such as urokinase for drug thrombolytic therapy. The interventional thrombolysis has the advantages of small trauma, short postoperative recovery time, few complications after treatment, good operation effect and the like, and can be accepted by patients. However, the method has the defects of long thrombolysis time, excessive dosage of medicine, easy bleeding, unstable thrombolysis effect and the like.
Ultrasonic enhanced thrombolysis has gained great attention because of its great potential in research for the treatment of thrombotic disorders, which utilizes cavitation effects, i.e., steady cavitation and transient cavitation, to destroy blood cells or relax the fibrin network structure of the thrombus. Ultrasonic cavitation refers to the dynamic process of forming, growing, shrinking and collapsing of micro bubble nuclei under the activation of sound waves, generally steady cavitation occurs under the condition of low sound pressure or sound intensity, micro bubbles undergo stable oscillation along with the periodical change of ultrasonic sound pressure to cause surrounding liquid to generate acoustic micro flow, when the sound pressure or sound intensity reaches a threshold value, the micro bubbles undergo rapid increase and then collapse process in a short time to generate intense micro-jet, the surrounding of the micro-jet is subjected to intense cavitation corrosion, the microscopic activity of ultrasonic thrombolysis is complex, the inflow of liquid to fibrin clots can be enhanced, the fibrin network is locally destroyed, and the thrombolytic drug under the assistance of ultrasonic waves can cause obvious clot quality loss on an animal stroke model, so that bleeding symptoms are reduced.
The prior art ultrasonic thrombolysis device is not designed to consider the heating problem of the ultrasonic transduction component in use, and the temperature emitted by the ultrasonic transduction component in long-time use can cause burn to a patient, thereby increasing the operation risk.
Disclosure of Invention
The embodiment of the invention provides a catheter for thrombolysis and an ultrasonic thrombolysis system, which are used for solving the problem that an ultrasonic transducer of the ultrasonic thrombolysis system heats in use to possibly burn a patient in the prior art.
According to a first aspect, an embodiment of the present invention provides a thrombolytic catheter, including: a catheter body and a drug injection member;
a cooling liquid cavity is formed in the catheter main body and is used for accommodating an ultrasonic catheter capable of emitting ultrasonic waves, a cooling liquid interface and an accommodating port are formed in the cooling liquid cavity in an opening way towards the outside of the catheter main body, the cooling liquid interface is used for injecting cooling liquid into the cooling liquid cavity, and the accommodating port is used for accommodating the ultrasonic catheter;
the drug injection piece is arranged at the far end of the catheter main body, a first drug injection cavity is formed on the drug injection piece, a drug injection hole is formed by opening the first drug injection cavity to the outside, a second drug injection cavity is formed on the catheter main body, the second drug injection cavity is communicated with the first drug injection cavity, a drug injection interface is formed by opening the second drug injection cavity to the outside, and the drug injection interface is used for injecting drugs into the second drug injection cavity.
As a further alternative of the thrombolytic catheter, the drug injection member includes a flared portion and a necked portion, the flared portion is connected between the two necked portions, the necked portion is used for being connected with the catheter body, the flared portion has two states of a contracted state and an expanded state, and the volume of the flared portion in the contracted state is smaller than the volume of the flared portion in the expanded state.
As a further alternative of the thrombolytic catheter, the expanding and contracting portion includes a plurality of drug injection tubes, the first drug injection chamber is formed in the drug injection tube, and the plurality of drug injection tubes are disposed in a grid shape or at intervals along an axial direction of the catheter body.
As a further alternative of the thrombolytic catheter, the catheter body includes an inner tube and a first outer tube, both of which are hollow structures, the coolant cavity is formed in the middle of the inner tube, the inner diameter of the first outer tube is larger than the outer diameter of the inner tube, the inner tube is nested in the first outer tube, and the second medicine injection cavity is formed between the outer surface of the inner tube and the inner surface of the first outer tube.
As a further alternative of the thrombolytic catheter, the axial length of the inner tube is greater than the axial length of the first outer tube such that the distal end of the inner tube protrudes from the first outer tube, the distal end of the inner tube is connected to one of the reduced portions, and the distal end of the first outer tube is connected to the other reduced portion, and the expanded and contracted portions can be switched between the contracted state and the expanded state by changing the relative positions of the inner tube and the first outer tube.
As a further alternative of the catheter for thrombolysis, the catheter body further includes a traction mechanism connected to the inner tube, the expansion and contraction part is made of a shape memory material, so that the expansion and contraction part is in one of the contracted state and the expanded state in a natural state in which no external force is applied, and the traction mechanism is used for applying a force to the inner tube or the expansion and contraction part, so that the drug injection is converted from the natural state to the other state.
As a further alternative of the catheter for thrombolysis, a suction lumen is formed in the catheter body, the suction lumen is opened to the outside to form a suction port for connection with a negative pressure device so that the negative pressure device can suck thrombus through the suction lumen.
As a further alternative of the catheter for thrombolysis, the catheter body includes an inner tube, a first outer tube and a second outer tube, the inner tube, the first outer tube and the second outer tube are hollow structures, an inner diameter of the second outer tube is larger than an outer diameter of the inner tube, an inner diameter of the first outer tube is larger than an outer diameter of the second outer tube, the second outer tube is sleeved outside the inner tube, a first cavity is formed between an outer surface of the inner tube and an inner surface of the second outer tube, the first outer tube is sleeved outside the second outer tube, a second cavity is formed between an outer surface of the second outer tube and an inner surface of the first outer tube, one of the first cavity and the second cavity forms the second drug injection cavity, and the other forms the suction cavity.
As a further alternative to the thrombolytic catheter, the thrombolytic catheter further comprises a temperature sensing assembly for detecting the temperature of the ultrasound transducer assembly on the ultrasound catheter.
According to a second aspect, an embodiment of the present invention provides an ultrasound thrombolysis system comprising an ultrasound catheter, an ultrasound generator and a thrombolytic catheter according to any of the preceding embodiments;
the ultrasonic catheter comprises an ultrasonic connector, a main body pipe and an ultrasonic transduction component, wherein the ultrasonic transduction component is arranged at the far end of the main body pipe, the ultrasonic transduction component is electrically connected with the ultrasonic connector, the ultrasonic connector is electrically connected with an ultrasonic generator, and the ultrasonic generator is used for exciting ultrasonic waves on the ultrasonic transduction component.
As a further alternative of the ultrasonic thrombolytic system, a suction lumen is formed in the catheter body, the suction lumen is opened to the outside to form a suction interface, the ultrasonic thrombolytic system further comprises a negative pressure device, the negative pressure device is communicated with the suction interface, so that the negative pressure device can suck thrombus through the suction lumen.
As a further alternative scheme of the ultrasonic bolt dissolving system, a first connector is arranged on the ultrasonic catheter, a second connector is arranged at the accommodating port, and the first connector can be in sealing connection with the second connector so as to seal the accommodating port.
The implementation of the embodiment of the invention has the following beneficial effects:
the thrombolysis catheter forms a cooling liquid cavity capable of accommodating the ultrasonic catheter in the catheter main body, so that a user can inject cooling liquid into the cooling liquid cavity to avoid the over-high temperature of the ultrasonic transduction assembly, thereby avoiding the burn of a patient caused by high temperature and reducing the risk of operation; the thrombolytic medicine is injected into the blood vessel by adopting the medicine injection piece to dissolve the thrombus, so that the ultrasonic thrombolytic treatment is carried out by matching with the ultrasonic catheter.
The ultrasonic thrombolysis system adopts an ultrasonic catheter to carry out ultrasonic thrombolysis treatment by matching with thrombolytic drugs emitted by a drug injection piece, ultrasonic energy is transmitted by a cooling liquid and the drug injection piece, the ultrasonic energy can cover the whole thrombolytic drug coverage, enhances the penetration of the thrombolytic drugs to the inside of thrombus, is beneficial to accelerating the speed of removing the thrombus, shortens the time of placing the catheter and reduces the usage amount of the thrombolytic drugs.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Wherein:
FIG. 1 is a schematic diagram of the overall structure of an ultrasonic thrombolysis system according to an embodiment of the present invention;
FIG. 2 is a schematic view of an ultrasound catheter according to an embodiment of the present invention;
FIG. 3 is an axial cross-sectional view of the distal portion of the ultrasound catheter of FIG. 2;
FIG. 4 is a cross-sectional view taken at A-A of FIG. 2;
FIG. 5 is a schematic view showing the overall structure of a thrombolytic catheter according to an embodiment of the present invention;
FIG. 6 is a schematic view of a portion of the thrombolytic catheter of FIG. 5 in a contracted state of the expandable portion;
FIG. 7 is a schematic view of the structure at B-B in FIG. 6;
FIG. 8 is a schematic view of the structure at C-C in FIG. 6;
FIG. 9 is a schematic view of the structure at D-D in FIG. 5;
description of main reference numerals:
10-catheter for thrombolysis, 11-catheter body, 111-first outer tube, 1111-second drug injection lumen, 1112-drug injection port, 112-second outer tube, 1121-suction lumen, 1122-suction port, 113-inner tube, 1131-coolant lumen, 1132-coolant port, 12-drug injection piece, 121-expansion and contraction part, 1211-first drug injection lumen, 1212-drug injection hole, 122-contraction part, 1221-mounting hole, 13-temperature sensing component, 131-temperature sensor, 132-temperature sensor wire, 133-temperature measurement connector, 14-second connector, 15-connecting machine, 16-slider;
20-an ultrasound catheter; 21-a main body tube; 22-an ultrasonic connector; 23-an ultrasonic transduction assembly; 231-an ultrasonic transducer; 232-a first wire; 233-a second wire; 24-a first connector;
30-an ultrasonic generator;
40-negative pressure device.
Detailed Description
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many other different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
In particular, in the present invention, the end of the medical instrument near the operator at the time of surgery is the proximal end of the medical instrument, and the end of the medical instrument far from the operator is the distal end of the medical instrument.
The embodiment of the invention provides a catheter for thrombolysis and an ultrasonic thrombolysis system, which are used for solving the problem that an ultrasonic transducer of the ultrasonic thrombolysis system heats in use to possibly burn a patient in the prior art.
In an embodiment of the present invention, referring to fig. 1, the ultrasonic thrombolysis system includes a thrombolysis catheter 10, an ultrasonic catheter 20, and an ultrasonic generator 30.
Referring to fig. 5 to 7, the thrombolytic catheter 10 includes a catheter body 11 and a drug injection device 12. The catheter body 11 is formed with a cooling fluid cavity 1131, the cooling fluid cavity 1131 is used for accommodating the ultrasonic catheter 20, the cooling fluid cavity 1131 is opened to the outside of the catheter body 11 to form a cooling fluid interface 1132 and an accommodating port, the cooling fluid interface 1132 is used for injecting cooling fluid into the cooling fluid cavity 1131, and the accommodating port is used for accommodating the ultrasonic catheter 20. The drug injection unit 12 is disposed at the distal end of the catheter body 11, a first drug injection cavity 1211 is formed in the drug injection unit 12, the first drug injection cavity 1211 is opened to the outside to form a drug injection hole 1212, a second drug injection cavity 1111 is formed in the catheter body 11, the second drug injection cavity 1111 is communicated with the first drug injection cavity 1211, a drug injection port 1112 is formed in the second drug injection cavity 1111 to the outside to open, and the drug injection port 1112 is used for injecting a drug into the second drug injection cavity 1111.
The ultrasonic catheter 20 comprises a main body tube 21, an ultrasonic connector 22 and an ultrasonic transducer assembly 23, wherein the ultrasonic transducer assembly 23 is arranged at the distal end of the main body tube 21, the ultrasonic transducer assembly 23 is electrically connected with the ultrasonic connector 22, the ultrasonic connector 22 is electrically connected with an ultrasonic generator 30, and the ultrasonic generator 30 is used for exciting ultrasonic waves on the ultrasonic transducer assembly 23.
The ultrasonic generator 30 may be designed in a manner that is more conventional in the art. Generally, the device may include a microprocessor, a display module, a power source, a phase accumulation module, a power management module, a waveform storage module, a digital-to-analog conversion module, a low-pass filtering module, a controllable gain amplification module, and an impedance matching module, where the waveform can be emitted includes square waves, sine waves, triangular waves, and the like, and is repeatedly emitted at multiple pulse intervals. Of course, other arrangements of the ultrasonic generator 30 are possible, as long as it is capable of exciting ultrasonic waves on the ultrasonic transducer assembly 23.
The using method of the ultrasonic thrombolysis system comprises the following steps: the cooling fluid interface 1132 and the drug injection interface 1112 of the thrombolytic catheter 10 are respectively connected with a fluid supply device such as an injector or an injection pump, and the fluid supply device injects fluid into the cooling fluid cavity 1131, the first drug injection cavity 1211 and the second drug injection cavity 1111 to perform air exhaust, and in general, the fluid adopted at this time is normal saline, so as to avoid damaging the steady state of the internal environment of the human body; subsequently, the thrombolytic catheter 10 is guided to a designated position by using a guide wire, the guide wire is withdrawn, the ultrasound catheter 20 is placed in the container port, the ultrasound transducer assembly 23 of the ultrasound catheter 20 is moved to the drug injection 12, and the ultrasound connector 22 is electrically connected with the ultrasound generator 30; the liquid supply device injects cooling liquid into the cooling liquid cavity 1131, the cooling liquid can also adopt normal saline, the other liquid supply device injects thrombolytic drugs into the first drug injection cavity 1211 and the second drug injection cavity 1111, and the thrombolytic drugs enter into blood from the drug injection holes 1212 to dissolve the thrombus; the ultrasonic generator 30 is started, so that ultrasonic waves are excited on the ultrasonic transduction component 23, high-frequency vibration generated by ultrasonic energy can generate strong negative pressure and positive pressure circulation in surrounding fluid, cavitation bubbles are formed by dissolved gas on the negative side of the pressure circulation, the bubbles rapidly break on the positive side of the pressure circulation, and strong mechanical shock waves are generated by breaking the cavitation bubbles to erode calcified plaques; meanwhile, ultrasound also has the characteristic of plaque ablation selectivity, and tissues with high collagen and elastin contents have extremely strong resistance to ultrasonic damage, however, tissues lacking these components are easily damaged, high-intensity ultrasonic waves damage fibrous or calcified plaques, normal blood vessels are not damaged, the ultrasonic transducer assembly 23 heats up and heats up during operation, and the temperature of the ultrasonic transducer assembly 23 can be maintained in a reasonable range by injecting cooling liquid into the cooling liquid cavity 1131.
The thrombolysis catheter 10 forms a cooling liquid cavity 1131 in the catheter main body 11, which can accommodate the ultrasonic catheter 20, so that a user can inject cooling liquid into the cooling liquid cavity 1131 to avoid the excessive temperature of the ultrasonic transduction assembly 23, thereby avoiding the burn of a patient caused by high temperature and reducing the risk of operation; the thrombolytic drug is injected into the blood vessel by the drug injection 12 to perform thrombolysis, thereby performing ultrasonic thrombolysis treatment in cooperation with the ultrasonic catheter 20.
The ultrasonic thrombolysis system adopts the ultrasonic catheter 20 to carry out ultrasonic thrombolysis treatment by matching with thrombolytic drugs emitted by the drug injection piece 12, ultrasonic energy is transmitted by the cooling liquid and the drug injection piece 12, the ultrasonic energy can cover the whole range covered by the thrombolytic drugs, the penetration of the thrombolytic drugs to the inside of thrombus is enhanced, the speed of removing the thrombus is facilitated to be accelerated, the time of placing a tube is shortened, and the usage amount of the thrombolytic drugs is reduced.
In one embodiment, referring to fig. 5 and 6 in combination, the drug injection device 12 includes a flared portion 121 and a flared portion 122, the flared portion 121 is connected between the two flared portions 122, the flared portion 122 is used for connecting with the catheter body 11, the flared portion 121 has two states, a contracted state and an expanded state, and the volume of the flared portion 121 in the contracted state is smaller than the volume in the expanded state.
In this embodiment, the catheter 10 for thrombolysis is in a contracted state with the expandable and contractible portion 121 in the course of advancing to a predetermined position along the guide wire, and after reaching the predetermined position, the expandable and contractible portion 121 is changed from the contracted state to the expanded state. The ultrasonic wave drives the expansion and contraction part 121 to vibrate, and the expansion and contraction part 121 mechanically cuts thrombus at the occlusion section, so that the ultrasonic energy transmission range is wider, the efficiency is higher, the loss is smaller, the inflow of thrombolytic drugs to fibrin clots can be enhanced, fibrin networks are locally destroyed, thrombus after the energy reaches the venous valve can be dissolved under the condition of not damaging the venous valve, the occurrence rate of PTS (post thrombus syndrome) is reduced, the time for placing a tube for thrombolysis is shortened, the effect of thrombolytic drugs is improved, the dosage of thrombolytic drugs is reduced, and the risk of bleeding is reduced.
In a specific embodiment, the expanding and contracting portion 121 includes a plurality of medicine injection tubes having the first medicine injection chamber 1211 formed therein, the plurality of medicine injection tubes being disposed in a mesh shape or disposed at intervals along the axial direction of the catheter main body 11. Specifically, when the drug injection tubes are disposed in a grid shape, the specific structure thereof may refer to the form shown in fig. 5 or 6, and when the drug injection tubes are disposed at intervals along the axial direction of the catheter main body 11, they may extend substantially straight along the axial direction of the catheter main body 11, or may extend spirally along the axial direction of the catheter main body 11. Of course, the form of the expansion/contraction section 121 is not limited to this, and those skilled in the art can set other forms as necessary.
In a more specific embodiment, referring to fig. 8, the necking portion 122 may be configured as a hoop, and a plurality of mounting holes 1221 are formed on the hoop, and an end portion of the drug injection tube is inserted into the mounting holes 1221.
In another more specific embodiment, the necking part 122 may be formed by the end part of the drug injection tube in a ring shape, and the end part of the drug injection tube in a ring shape may be wrapped with a protective layer, and the protective layer may play a role in protection and fixation.
For the formation of the second drug injection cavity 1111, in a specific embodiment, please refer to fig. 9 (fig. 9 is a structure of another embodiment of the catheter body 11, omitting the second outer tube 112 and the suction cavity 1121 in fig. 9, which can be used as references in this embodiment), the catheter body 11 includes a first outer tube 111 and an inner tube 113, both the inner tube 113 and the first outer tube 111 are hollow structures, the cooling fluid cavity 1131 is formed in the middle of the inner tube 113, the inner diameter of the first outer tube 111 is larger than the outer diameter of the inner tube 113, the inner tube 113 is nested in the first outer tube 111, and the second drug injection cavity 1111 is formed between the outer surface of the inner tube 113 and the inner surface of the first outer tube 111.
In another specific embodiment, the catheter body 11 includes a first outer tube 111 and an inner tube 113, and the wall of the first outer tube 111 is provided with a plurality of fluid channels extending along the axial direction thereof (the cross-sectional shape of the catheter body 11 in this embodiment is the same as that of fig. 8), and the fluid channels form a second drug injection cavity 1111.
Based on the above two embodiments, in a more specific embodiment, the axial length of the inner tube 113 is greater than the axial length of the first outer tube 111, so that the distal end of the inner tube 113 protrudes from the first outer tube 111, the distal end of the inner tube 113 is connected to one of the reduced mouth portions 122, the distal end of the first outer tube 111 is connected to the other reduced mouth portion 122, and the expanding and contracting portion 121 can be switched between the contracted state and the expanded state by changing the relative positions of the inner tube 113 and the first outer tube 111.
In a more specific embodiment, the catheter body 11 further comprises a traction mechanism connected to the inner tube 113, and the expansion and contraction part 121 is made of a shape memory material, so that the expansion and contraction part 121 is in one of the contracted state and the expanded state in a natural state in which no external force is applied, and the traction mechanism is used to apply a force to the inner tube 113 or the expansion and contraction part 121, so that the drug injection 12 is converted from the natural state to the other state.
In a further specific embodiment, the traction mechanism may be configured as a traction rope, the traction rope is connected to the inner tube 113, and is in a contracted state in the natural state of the expanding and contracting portion 121, at this time, the thrombolytic catheter 10 may be moved to the target position, after the thrombolytic catheter 10 reaches the target position, the user may pull the traction rope in the proximal direction, so that the inner tube 113 drives the contracting portion 122 to move proximally, so that the expanding and contracting portion 121 is converted from the contracted state to the expanded state, and when the thrombolytic catheter 10 needs to be removed, the traction rope may be loosened, and the expanding and contracting portion 121 may be automatically restored to the contracted state because the expanding and contracting portion is made of a shape memory material. The traction mechanism can be further arranged as a limiting tube, the limiting tube is sleeved outside the first outer tube 111, the natural state of the expanding and contracting portion 121 is an expanding state, the limiting tube is moved to the far end to wrap the expanding and contracting portion 121, the expanding and contracting portion 121 can be converted into a contracting state from the expanding state, the limiting tube is withdrawn to the near end, and the expanding and contracting portion 121 can be converted into the expanding state from the contracting state.
In the foregoing embodiments, the shape memory materials include, but are not limited to, alloy shape memory materials and polymeric shape memory materials, with metallic shape memory materials being preferred in practice.
In another more specific embodiment, the catheter main body 11 further includes a traction mechanism, where the traction mechanism may be a traction rod or other element capable of bearing a tensile force and a compressive force, and the traction rod is connected to the inner tube 113, and by moving the traction rod distally or proximally, the inner tube 113 may be used to drive the pinch portion 122 to move, so that the pinch portion 121 is switched between a contracted state and an expanded state.
Based on the setting of the traction mechanism, more specifically, the proximal end of the catheter body 11 is provided with a connector 15, a slider 16 is slidably connected to the connector 15, the slider 16 is connected to the traction mechanism, and a user can control the movement of the traction mechanism by moving the slider 16. Further, a locking structure may be added between the connector 15 and the slider 16, and the locking structure is used to facilitate the user to fix the slider 16 at a desired position of the connector 15.
In the foregoing embodiments related to the traction mechanism, the traction mechanism may be matched with the driving element and the control element to realize automatic switching of the state of the expansion and contraction part 121.
In one embodiment, a suction lumen 1121 is also formed within the catheter body 11, the suction lumen 1121 opening to the outside to form a suction interface 1122, the suction interface 1122 being for connection with the negative pressure device 40 such that the negative pressure device 40 is capable of aspirating thrombus via the suction lumen 1121.
At this point, the ultrasonic thrombolysis system further includes a negative pressure device 40, the negative pressure device 40 being in communication with the suction interface 1122 such that the negative pressure device 40 is capable of aspirating thrombi via the suction lumen 1121.
In a specific embodiment, referring to fig. 9, the catheter main body 11 includes an inner tube 113, a first outer tube 111 and a second outer tube 112, where the inner tube 113, the first outer tube 111 and the second outer tube 112 are hollow, the inner diameter of the second outer tube 112 is larger than the outer diameter of the inner tube 113, the inner diameter of the first outer tube 111 is larger than the outer diameter of the second outer tube 112, the second outer tube 112 is sleeved outside the inner tube 113, so that a first cavity is formed between the outer surface of the inner tube 113 and the inner surface of the second outer tube 112, the first outer tube 111 is sleeved outside the second outer tube 112, so that a second cavity is formed between the outer surface of the second outer tube 112 and the inner surface of the first outer tube 111, one of the first cavity and the second cavity forms a second drug injection cavity 1111, and the other forms a suction cavity 1121.
Preferably, the first cavity is referred to as a pumping cavity 1121 and the second cavity is referred to as a second drug injection cavity 1111. In this arrangement, the proximal end of the reduced portion 122 may be connected to the first outer tube 111 and the second outer tube 112, respectively, and the distal end of the reduced portion 122 may be connected to the inner tube 113, at this time, a space exists between the reduced portion 122 and the inner tube 113, so that the reduced portion 122 is prevented from obstructing the movement of the inner tube 113.
In one embodiment, the thrombolytic catheter 10 further comprises a temperature sensing assembly 13, the temperature sensing assembly 13 being adapted to detect the temperature of the ultrasound transducer assembly 23 on the ultrasound catheter 20.
In a specific embodiment, please refer to fig. 5 to 8 in combination, the temperature sensor assembly 13 includes a temperature sensor 131, a temperature sensor wire 132 and a temperature measurement connector 133, the temperature sensor 131 is disposed on a wall of the cooling liquid cavity 1131, the temperature sensor wire 132 is electrically connected to the temperature sensor 131, the temperature sensor wire 132 is connected to the temperature measurement connector 133, the temperature measurement connector 133 is used for connecting to the ultrasonic generator 30, and at this time, the temperature sensor 131 is controlled by a micro-control chip in the ultrasonic generator 30.
In one embodiment, referring to fig. 3, the ultrasonic transducer assembly 23 includes an ultrasonic transducer 231, a first conductive wire 232 and a second conductive wire 233, the first conductive wire 232 is disposed at the distal end of the main body tube 21, the ultrasonic transducer 231 is annular and sleeved on the outer surface of the first conductive wire 232 and electrically connected with the first conductive wire 232, the second conductive wire 233 is electrically connected with the outer surface of the ultrasonic transducer 231, and the first conductive wire 232 and the second conductive wire 233 are electrically connected with the ultrasonic connector 22.
In one embodiment, the ultrasound catheter 20 is provided with a first connector 24, and the thrombolytic catheter 10 is provided with a second connector 14 at the receiving port, and the first connector 24 can be connected with the second connector 14 in a sealing manner to close the receiving port.
In a specific embodiment, the first connector 24 and the second connector 14 are provided as luer connectors.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (12)
1. A thrombolytic catheter, comprising: a catheter body and a drug injection member;
a cooling liquid cavity is formed in the catheter main body and is used for accommodating an ultrasonic catheter capable of emitting ultrasonic waves, a cooling liquid interface and an accommodating port are formed in the cooling liquid cavity in an opening way towards the outside of the catheter main body, the cooling liquid interface is used for injecting cooling liquid into the cooling liquid cavity, and the accommodating port is used for accommodating the ultrasonic catheter;
the drug injection piece is arranged at the far end of the catheter main body, a first drug injection cavity is formed on the drug injection piece, a drug injection hole is formed by opening the first drug injection cavity to the outside, a second drug injection cavity is formed on the catheter main body, the second drug injection cavity is communicated with the first drug injection cavity, a drug injection interface is formed by opening the second drug injection cavity to the outside, and the drug injection interface is used for injecting drugs into the second drug injection cavity.
2. The catheter for thrombolysis according to claim 1, wherein the drug injection member comprises a flared portion and a necked portion, the flared portion being connected between the two necked portions, the necked portion being for connection with the catheter body, the flared portion having both a contracted state and an expanded state, the flared portion having a smaller volume in the contracted state than in the expanded state.
3. The catheter for thrombolysis according to claim 2, wherein the expanding and contracting portion comprises a plurality of drug injection tubes, wherein the first drug injection cavity is formed in the drug injection tube, and the plurality of drug injection tubes are arranged in a grid shape or are arranged at intervals along the axial direction of the catheter main body.
4. The catheter for thrombolysis according to claim 2, wherein the catheter body comprises an inner tube and a first outer tube, both of which are hollow structures, the cooling liquid cavity is formed in the middle of the inner tube, the inner diameter of the first outer tube is larger than the outer diameter of the inner tube, the inner tube is nested in the first outer tube, and the second medicine injection cavity is formed between the outer surface of the inner tube and the inner surface of the first outer tube.
5. The thrombolytic catheter according to claim 4, wherein the axial length of said inner tube is greater than the axial length of said first outer tube such that the distal end of said inner tube extends from said first outer tube, the distal end of said inner tube being connected to one of said reduced mouth portions and the distal end of said first outer tube being connected to the other of said reduced mouth portions, said expanded and contracted portions being switchable between said contracted and expanded states by changing the relative positions of said inner tube and said first outer tube.
6. The thrombolytic catheter according to claim 5, wherein said catheter body further comprises a traction mechanism connected to said inner tube, said expansion and contraction portion is made of a shape memory material such that said expansion and contraction portion is in one of said contracted state or expanded state in a natural state in which no external force is applied thereto, said traction mechanism being adapted to apply a force to said inner tube or said expansion and contraction portion such that said drug injection member is shifted from the natural state to the other state.
7. A catheter for thrombolysis according to any one of claims 1-3, wherein a suction lumen is further formed in said catheter body, said suction lumen being open to the outside forming a suction interface for connection with a negative pressure device such that said negative pressure device can aspirate thrombus via said suction lumen.
8. The catheter for thrombolysis according to claim 7, wherein the catheter body comprises an inner tube, a first outer tube and a second outer tube, wherein the inner tube, the first outer tube and the second outer tube are hollow structures, an inner diameter of the second outer tube is larger than an outer diameter of the inner tube, an inner diameter of the first outer tube is larger than an outer diameter of the second outer tube, the second outer tube is sleeved outside the inner tube so that a first cavity is formed between an outer surface of the inner tube and an inner surface of the second outer tube, the first outer tube is sleeved outside the second outer tube so that a second cavity is formed between an outer surface of the second outer tube and an inner surface of the first outer tube, one of the first cavity and the second cavity constitutes the second drug injection cavity, and the other constitutes the suction cavity.
9. The thrombolytic catheter of claim 1, further comprising a temperature sensing assembly for detecting a temperature of an ultrasonic transducer assembly on said ultrasonic catheter.
10. An ultrasonic thrombolysis system comprising an ultrasonic catheter, an ultrasonic generator, and a thrombolysis catheter according to any one of claims 1-9;
the ultrasonic catheter comprises an ultrasonic connector, a main body pipe and an ultrasonic transduction component, wherein the ultrasonic transduction component is arranged at the far end of the main body pipe, the ultrasonic transduction component is electrically connected with the ultrasonic connector, the ultrasonic connector is electrically connected with an ultrasonic generator, and the ultrasonic generator is used for exciting ultrasonic waves on the ultrasonic transduction component.
11. The ultrasonic thrombolysis system of claim 10, wherein a suction lumen is formed in said catheter body, said suction lumen being open to the outside to form a suction port, said ultrasonic thrombolysis system further comprising a negative pressure device in communication with said suction port such that said negative pressure device is capable of aspirating thrombus via said suction lumen.
12. The ultrasonic thrombolysis system according to claim 10, wherein a first connector is provided on said ultrasonic catheter, a second connector is provided at said receiving port, said first connector can be sealingly connected with said second connector to close said receiving port.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310862851.6A CN116849760A (en) | 2023-07-13 | 2023-07-13 | Catheter for thrombolysis and ultrasonic thrombolysis system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310862851.6A CN116849760A (en) | 2023-07-13 | 2023-07-13 | Catheter for thrombolysis and ultrasonic thrombolysis system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116849760A true CN116849760A (en) | 2023-10-10 |
Family
ID=88230120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310862851.6A Pending CN116849760A (en) | 2023-07-13 | 2023-07-13 | Catheter for thrombolysis and ultrasonic thrombolysis system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116849760A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117598755A (en) * | 2024-01-24 | 2024-02-27 | 上海佳沐垚医疗科技有限公司 | Ultrasonic recanalization system |
-
2023
- 2023-07-13 CN CN202310862851.6A patent/CN116849760A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117598755A (en) * | 2024-01-24 | 2024-02-27 | 上海佳沐垚医疗科技有限公司 | Ultrasonic recanalization system |
| CN117598755B (en) * | 2024-01-24 | 2024-05-07 | 上海佳沐垚医疗科技有限公司 | Ultrasonic recanalization system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Trübestein et al. | Thrombolysis by ultrasound | |
| JP4890674B2 (en) | Sheath used for ultrasonic elements | |
| US11179169B2 (en) | Device for delivering mechanical waves through a balloon catheter | |
| US6605055B1 (en) | Balloon catheter with irrigation sheath | |
| WO2023240937A1 (en) | Multifunctional thrombus removal apparatus | |
| US6387109B1 (en) | Methods and device for improving blood flow to heart of a patient | |
| JP4280865B2 (en) | Transcutaneous pringle occlusion device | |
| WO1988003783A1 (en) | Ultrasonic surgical apparatus | |
| US20220249121A1 (en) | Thrombus treatment platform | |
| US20100023033A1 (en) | Hydrodynamic Thrombectomy Catheter | |
| US20040249401A1 (en) | Apparatus and method for an ultrasonic medical device with a non-compliant balloon | |
| US20100022943A1 (en) | Hydrodynamic Thrombectomy Catheter | |
| CN109700525A (en) | Stoma instrument | |
| JPS6363450A (en) | Water jet operation apparatus | |
| JP2002500523A (en) | Method and apparatus for improving blood flow to a patient's heart | |
| WO2005034793A2 (en) | Apparatus and method for an ultrasonic medical device with a non-compliant balloon | |
| CN116849760A (en) | Catheter for thrombolysis and ultrasonic thrombolysis system | |
| WO2024045386A1 (en) | Thrombolytic apparatus | |
| WO2024114761A1 (en) | Lumen opening instrument, lumen opening system, and lumen opening method | |
| CN108309432A (en) | Cryogenic ablation conduit, cryogenic ablation operating device and cryogenic ablation equipment | |
| US20200107843A1 (en) | Systems and Methods for Treating Vascular Occlusions with Catheter Based Ultrasound | |
| WO2024114764A1 (en) | Ultrasonic thrombolysis device, ultrasonic thrombolysis system, and thrombolysis method | |
| JPH0263015B2 (en) | ||
| CN112754600A (en) | Split type sawtooth-shaped thrombus breaking balloon catheter | |
| CN114246637A (en) | Intracranial thrombus suction catheter device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhou Xinhuan Inventor after: Liu Yuqin Inventor before: He Jingcai Inventor before: Zhou Xinhuan Inventor before: Liu Yuqin Inventor before: Fang Zhenggang Inventor before: Che Musen |