CN116849222A - Application of prothioconazole-containing pesticide composition in preventing and controlling diseases and insect pests of wheat - Google Patents
Application of prothioconazole-containing pesticide composition in preventing and controlling diseases and insect pests of wheat Download PDFInfo
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- CN116849222A CN116849222A CN202310836251.2A CN202310836251A CN116849222A CN 116849222 A CN116849222 A CN 116849222A CN 202310836251 A CN202310836251 A CN 202310836251A CN 116849222 A CN116849222 A CN 116849222A
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- wheat
- pesticide composition
- active ingredient
- prothioconazole
- seed treatment
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- QPDUQKTYZRXRBC-UHFFFAOYSA-N triazole-4-thione Chemical compound S=C1C=NN=N1 QPDUQKTYZRXRBC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01C—PLANTING; SOWING; FERTILISING
- A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01C—PLANTING; SOWING; FERTILISING
- A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
- A01C1/06—Coating or dressing seed
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/02—Acaricides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Soil Sciences (AREA)
- Insects & Arthropods (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticide disinsection and sterilization, and relates to application of a pesticide composition containing prothioconazole in preventing and controlling diseases and insect pests of wheat. The pesticide composition provided by the invention has the effects of preventing and controlling wheat diseases and insect pests, the action mechanisms of the components are different, the synergistic effect can be achieved after the components are compounded, and the dosage of the pesticide is reduced.
Description
Technical Field
The invention belongs to the technical field of pesticide disinsection and sterilization, and in particular relates to application of a pesticide composition containing prothioconazole in preventing and controlling diseases and insect pests of wheat.
Background
The prothioconazole is a novel broad-spectrum triazolethione bactericide developed by Bayer company, is mainly used for preventing and treating various diseases of crops such as grains, wheat, beans and the like, has low toxicity, is free from teratogenesis and causes mutant, and is safe to people and environment. The mechanism of action is to inhibit demethylation of lanosterol, the precursor of sterols in fungi, or 2, 4-methylenedihydrolanosterol at position 14. The structural formula is as follows:
fludioxonil is a novel pyrrole non-systemic broad-spectrum bactericide. As a seed treatment bactericide, the suspended seed coating agent can prevent and treat various diseases. The fludioxonil irrigates roots or treats soil and has very good effects on a plurality of root diseases such as damping off, root rot, fusarium wilt, gummy stem blight and the like of various crops. In addition, fludioxonil can also be used as spray for controlling gray mold and sclerotinia of various crops. The fludioxonil has excellent safety on crop seeds, does not influence the emergence of the seeds, and can promote the seeds to emerge in advance, so that the seedlings emerge in good order and grow well. The structural formula is as follows:
the action mechanism of clothianidin is that clothianidin is used as an agonist of nicotinic acetylcholine receptor (nAChRs) to selectively combine with the acetylcholine receptor, compete with insect acetylcholine, block normal transmission of central nerve and further lead to paralysis and death of insects. Because the pesticide has a unique action mechanism and has no cross resistance with the conventional pesticide, the pesticide has high efficiency, broad spectrum and good root systemic, contact killing and stomach poisoning effects, has low toxicity to mammals, can effectively control pests such as homoptera, coleopteran, dipteran and lepidoptera, and has good activity on pests which generate drug resistance by using the conventional pesticide.
Patent application publication No. CN112970765A discloses a ternary compound seed dressing agent for controlling plant diseases and insect pests, but does not specifically disclose related preparations or efficacy tests of prothioconazole and fludioxonil and clothianidin. CN110432277a discloses an insecticidal and bactericidal composition for rice seed treatment, and specifically discloses the insecticidal and bactericidal composition for preventing and controlling rice bakanae disease and rice thrips. However, ternary combination of prothioconazole, fludioxonil and clothianidin is used for preventing and controlling diseases and insect pests of wheat, especially stem rot of wheat and wheat aphid, and no report is given. On the basis of a large number of experiments, the applicant finds that the ternary combination of prothioconazole, fludioxonil and clothianidin has a synergistic effect in preventing and controlling diseases and insect pests of wheat, especially preventing and controlling wheat root rot and wheat aphid.
Disclosure of Invention
Based on the above circumstances, the invention aims to provide the application of the prothioconazole-containing pesticide composition in preventing and controlling wheat diseases and insect pests, and the composition can enhance the pesticide effect, has obvious prevention effect on wheat root rot and wheat aphids, reduces the dosage, and can prolong the duration and delay the development of drug resistance.
In order to achieve the above purpose, the application of the pesticide composition containing prothioconazole in preventing and controlling diseases or insect pests of wheat comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is prothioconazole, the active ingredient B is fludioxonil, and the pesticide composition further comprises clothianidin;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:10-10:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:10, 1:8, 1:4, 1:2, 1:1, 2:1, 5:2, 3:1, 4:1, 8:1 and 10:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:8-3:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:8, 1:4, 1:2, 1:1, 2:1, 5:2 and 3:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:4-5:2;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:4, 1:2, 1:1, 2:1 and 5:2;
further, the mass ratio of the active component A to the active component B is 2:1;
further, the sum of the contents of the active ingredient A in the pesticide composition is 0.5 to 50 percent based on 100 weight percent of the total weight of the pesticide composition;
further, the content of the active ingredient A in the pesticide composition is 1% -10%;
further, the content of the active ingredient A in the pesticide composition is 1% -5%;
further, the content of the active ingredient A in the pesticide composition is 3%;
further, the content of the active ingredient B in the pesticide composition is 0.5-50% based on 100wt% of the total weight of the pesticide composition;
further, the content of the active ingredient B in the pesticide composition is 1% -10%;
further, the content of the active ingredient B in the pesticide composition is 1% -5%;
further, the content of the active ingredient B in the pesticide composition is 1.5%;
further, the content of the neonicotinoid insecticide in the pesticide composition is 10-50% based on 100wt% of the total weight of the pesticide composition;
further, the content of the clothianidin in the pesticide composition is 10% -45%;
further, the content of the clothianidin in the pesticide composition is 10% -35%;
further, the sum of the contents of the active ingredient A and the active ingredient B in the pesticide composition is 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5% and 8% based on 100wt% of the total weight of the pesticide composition;
further, the sum of the contents of the active ingredient A and the active ingredient B in the pesticide composition is 4.5 percent based on 100 weight percent of the total weight of the pesticide composition;
further, the content of the clothianidin insecticide in the pesticide composition is 10%, 15%, 25%, 35% and 45% based on 100wt% of the total weight of the pesticide composition;
further, the content of clothianidin in the pesticide composition is 25% based on 100wt% of the total weight of the pesticide composition;
further, the pesticide composition comprises clothianidin as an active ingredient: prothioconazole: the mass ratio of the fludioxonil is (5-45) 3:1.5;
further, the pesticide composition comprises clothianidin as an active ingredient: prothioconazole: the mass ratio of the fludioxonil is (10-45) 3:1.5;
further, the active ingredient clothianidin in the pesticide composition comprises the following components: prothioconazole: the mass ratio of fludioxonil is 10:3:1.5, 15:3:1.5, 25:3:1.5, 35:3:1.5, 45:3:1.5;
further, the active ingredient clothianidin in the pesticide composition comprises the following components: prothioconazole: the mass ratio of fludioxonil is 25:3:1.5;
further, the pesticide composition further comprises an auxiliary agent selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreezes, defoamers, solvents, preservatives, stabilizers, guard colors, film formers, synergists and carriers;
the wetting agent is selected from one or more of alkylbenzene sulfonate, alkyl naphthalene sulfonate, lignin sulfonate, sodium dodecyl sulfate, dioctyl sodium sulfosuccinate, alpha olefin sulfonate, alkylphenol ethoxylate, castor oil polyoxyethylene ether, alkylphenol ethoxylate, fatty alcohol polyoxyethylene ether sodium sulfate, silkworm excrement, spina gleditsiae powder, soapberry powder, SOPA, detergent, emulsifier 2000 series and wetting penetrating agent F; and/or
The dispersing agent is selected from one or more of lignosulfonate, alkyl naphthalene sulfonate formaldehyde condensate, naphthalene sulfonate, tristyrylphenol ethoxylate phosphate, fatty alcohol ethoxylate, alkylphenol ethoxylate methyl ether condensate sulfate, fatty amine ethoxylate, glycerin fatty acid ester polyoxyethylene ether, polycarboxylate, polyacrylic acid, phosphate, EO-PO block copolymer and EO-PO graft copolymer; and/or
The emulsifier is one or more selected from calcium dodecyl benzene sulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenethyl phenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrylphenol polyoxyethylene ether, castor oil polyoxyethylene ether and alkylphenol ether phosphate; and/or
The thickener is one or more selected from xanthan gum, organic bentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose and white carbon black; and/or
The disintegrating agent is one or more selected from sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid; and/or
The antifreezing agent is one or more selected from alcohols, alcohol ethers, chlorinated hydrocarbons and inorganic salts; and/or
The defoamer is selected from C 10 -C 20 Saturated fatty acid compound, silicone oil, silicone compound, C 8 -C 10 One or more of the fatty alcohols; and/or
The solvent is selected from one or more of benzene, toluene, xylene, durene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, alkylene carbonate, diesel oil, solvent oil, vegetable oil derivatives and water; and/or
The preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, pinocembrane and 1, 2-benzisothiazolin-3-one; and/or
The stabilizer is one or more selected from disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2, 6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, white carbon black, talcum powder, montmorillonite and starch; and/or
The warning color is selected from any one or more of blue, green, red and purple regulating colors; and/or
The film forming agent is one or more of sodium carboxymethyl starch, cellulose derivatives (sodium carboxymethyl cellulose, sodium alginate, polyvinyl alcohol) and polyacrylic acid; and/or
The synergistic agent is selected from synergistic phosphorus and synergistic ether; and/or
The carrier is selected from one or more of ammonium salt, ground natural mineral, ground artificial mineral, silicate, resin, wax, solid fertilizer, water, organic solvent, mineral oil, vegetable oil and vegetable oil derivative;
further, the pesticide composition is in the form of any one of a seed treatment solid preparation or a seed treatment liquid preparation;
further, the pesticide composition is in the form of any one of seed treatment dry powder, seed treatment dispersible powder, seed treatment liquid, seed treatment emulsion or seed treatment suspending agent;
further, the pesticide composition is in the form of a seed treatment suspending agent;
the wheat diseases are wheat root rot, wheat rust, wheat powdery mildew, wheat leaf blight, wheat scab, wheat smut, wheat sheath blight, wheat take-all, wheat black embryo and/or wheat yellow dwarf;
further, the wheat disease is wheat root rot;
wheat root rot is a global disease, is also one of important diseases of Chinese wheat, and occurs in all wheat planting areas. Wheat root rot is widely distributed, and particularly occurs more heavily in rainy years and humid areas. The early withering of leaves is often caused after wheat is infected, the grouting of seeds is affected, and thousand grain weight is reduced. After the ear part is infected, the ear part can be dried and whitely ear, and the influence on the yield and quality is larger. The seed tape disease rate is high, the germination rate can be reduced, the root rot is caused, and the emergence and the seedling growth of wheat are seriously affected. The pathogen is Gramineae (Cochliobolus sativus (Ito & Kurib.) Drechsler), belonging to the genus Leuconostoc. The asexual state is the root rot of wheat, the helminth (Bipolaris sorokiniana (sacc.) Shemaker), belonging to the asexual fungus.
The wheat insect pest is wheat aphid, wheat spider mite, wheat pulp sucking insect, myxoma, flammulina velutipes and/or wheat root bug;
further, the wheat insect pest is wheat aphid;
the wheat aphid commonly called as oil worm, fatiguing worm and honey worm is one of main pests of wheat, and can be used for piercing and sucking harm to wheat, and affecting photosynthesis, nutrient absorption and transmission of wheat. After wheat is ear-picked, the wheat is concentrated on the ear to form blighted grains, so that thousand grain weight is reduced to reduce yield. All wheat regions of the world occur. The plant is mainly harmful to wheat and other gramineous crops and weeds, nymphs and adults are often clustered in a large amount to absorb juice on leaves, stems and ears, and the harmful parts are formed into yellow small spots, and then strip spots are withered and the whole plant becomes withered to death. The juice of the stems, leaves and ears of wheat plants is sucked by adults and nymphs. After wheat seedlings are damaged, the leaves are withered and yellow, the growth is stagnant, and tillering is reduced; after the wheat plants in the later period are damaged, the leaves are yellow, the wheat grains are not full, and when the wheat grains are serious, the wheat ears are withered and white, cannot be firm, and even the whole wheat plants die. The pest of wheat aphid mainly comprises two aspects of direct pest and indirect pest: directly harmful to the adult aphids, which suck the juice of leaves, stems, heads and ears; indirect pest refers to that wheat aphid can spread wheat virus disease at the same time as pest, wherein wheat yellow dwarf disease is the biggest pest.
Further, the pesticide composition disclosed by the invention is applied to a medium on which wheat diseases or insect pests occur.
Compared with the prior art, the technical scheme of the invention has the following beneficial effects:
1) The pesticide composition can treat insect pests and diseases of wheat, has obvious control effect on wheat root rot and wheat aphid, expands control spectrum, saves labor force and saves production cost;
2) After being compounded, the three active components in the pesticide composition have a certain synergistic effect on the control of plant diseases and insect pests in a certain range, and the control effect is improved;
3) The pesticide composition can prolong the duration of the pesticide, reduce the times of using the pesticide, delay the generation of pesticide resistance of pests and harmful bacteria and prolong the service life of single pesticide.
Detailed Description
The present invention will be described in more detail with reference to the following examples, but the present invention can be embodied in various forms and should not be construed as being limited to the embodiments set forth herein.
Preparation example:
the preparation process of the seed treatment suspending agent comprises the following steps: the active ingredients, the auxiliary agent and the water are subjected to high-shear mixing and stirring uniformly according to the proportion, and then are subjected to sand grinding for 2.5 hours by a sand grinder, so that the average particle size reaches 1-5 microns, and finally, the thickening agent and the preservative film forming agent are added for continuous shearing and stirring uniformly, so that the seed treatment suspending agent can be obtained.
Preparation example 1:18% clothianidin prothioconazole fludioxonil seed treatment suspending agent (15% +2% + 1%)
Preparation example 2:39.5% clothianidin prothioconazole fludioxonil seed treatment suspending agent (35% +3% + 1.5%)
Preparation example 3:29.5% clothianidin prothioconazole fludioxonil seed treatment suspending agent (25% +3% + 1.5%)
Comparative example 1 28% clothianidin prothioconazole seed treatment suspension (25% + 3%)
| Component (A) | Content of |
| Clothianidin | 25％ |
| Prothioconazole | 3％ |
| Castor oil polyoxyethylene ether | 2％ |
| Alkylphenol polyoxyethylene ether phosphate | 3％ |
| Naphthalene sulfonate formaldehyde condensate | 2％ |
| Polyacrylic emulsion | 1％ |
| Xanthan gum | 0.2％ |
| Rose pigment | 6％ |
| Ethylene glycol | 5％ |
| Magnesium aluminum silicate | 1％ |
| Organosilicon defoamer | 0.5％ |
| Sodium benzoate | 1％ |
| Deionized water | Make up for the allowance |
Comparative example 2:26.5% clothianidin fludioxonil seed treatment suspending agent (25% + 1.5%)
Comparative example 3:70% clothianidin prothioconazole fludioxonil seed treatment suspending agent (45% +20% + 5%)
Comparative example 4:55% clothianidin prothioconazole fludioxonil seed treatment suspending agent (35% +15% + 5%)
| Component (A) | Content of |
| Clothianidin | 35％ |
| Prothioconazole | 15％ |
| Fludioxonil | 5％ |
| Fatty alcohol polyoxyethylene ether sulfonate | 7％ |
| Polyurethane modified nitrocellulose | 10％ |
| Acacia gum | 1.5％ |
| Bright red | 2％ |
| Sodium salicylate | 0.3％ |
| Ethylene glycol | 2％ |
| Deionized water | Make up for the allowance |
Comparative example 5:40% clothianidin prothioconazole fludioxonil seed treatment suspending agent (25% +10% + 5%)
| Component (A) | Content of |
| Clothianidin | 25％ |
| Prothioconazole | 10％ |
| Fludioxonil | 5％ |
| Alkylphenol polyoxyethylene sulfonate | 10％ |
| Polyethylene glycol-gelatin-gum arabic condensate | 8％ |
| Acrylic acid sodium salt | 1.5％ |
| Bright blue | 2％ |
| SorbitolAcid(s) | 0.2％ |
| Sodium chloride | 3％ |
| Deionized water | Make up for the allowance |
Comparative example 6:28.49% thiamethoxam prothioconazole fludioxonil seed treatment suspending agent (25.25% +2.16% + 1.08%)
The formulation composition and preparation method of the film former of comparative example 6 above refer to the formulation composition and preparation method of film former 2 in CN114568445 a:
dissolving polyvinyl alcohol in hot water at 100 ℃ to prepare a polyvinyl alcohol solution with the mass fraction of 5%, and cooling to room temperature for standby;
preparing vinyl acetate-ethylene copolymer emulsion with the mass fraction of 15% into vinyl acetate-ethylene copolymer emulsion for later use by vigorously stirring;
100g of polyvinyl alcohol solution, 10g of vinyl acetate-ethylene copolymer emulsion, 5g of attapulgite, 2g of waterproof film-forming additive and 3g of phosphotungstic acid are fully and uniformly stirred at room temperature to prepare the film-forming agent.
Comparative example 8:29.5% thiamethoxam prothioconazole fludioxonil seed treatment suspension (25% +3% + 1.5%)
Indoor activity test:
example 1: indoor toxicity test for wheat root rot
The test is based on: test reference NY/T1156.2-2006 agricultural industry standard "pesticide indoor bioassay test criteria section 2 of the people's republic of China: test plate method for inhibiting growth of pathogenic bacterial hyphae.
Test target: helminth, helminth (Bipolaris sorokiniana), supplied by the national institute of chemical industry.
Instrument apparatus: high pressure steam sterilizer, ultra clean bench, incubator, electrothermal blowing dry box, ten thousandth electronic balance, pipettor, alcohol lamp, beaker (50 mL), volumetric flask, triangular flask (100 mL), culture dish (Φ9cm), puncher (Φ0.6cm), inoculator, ruler, etc.
Test target culture conditions: the helminthicus umbilicus preserved at the indoor temperature of 4 ℃ is transferred onto potato dextrose agar culture medium, and is activated for standby after being placed in a 25 ℃ incubator for 6 days of dark culture.
Test agent: 97% prothioconazole technical, 98% fludioxonil technical and 98% clothianidin technical are provided by the research and development center of the sea li pharmaceutical industry group.
Other reagents: acetone (analytically pure), tween 80 (chemically pure).
And (3) preparation of a medicament mother solution: the method comprises the steps of respectively dissolving prothioconazole, fludioxonil and clothianidin by acetone to prepare high-concentration mother liquor, and then dissolving prothioconazole: the fludioxonil is prepared into 11 groups of mixed solutions according to the proportion of 1:10, 1:8, 1:4, 1:2, 1:1, 2:1, 5:2, 3:1, 4:1, 8:1 and 10:1, and the single agent and the mixed agents are diluted into 5 series of mass concentrations by using 0.1% Tween 80 aqueous solution.
On the basis, the better mixture ratio of prothioconazole and fludioxonil is screened, and the better mixture ratio mixture is used as a bactericide combination to be subjected to ternary compounding with clothianidin according to different mass ratios.
Test replicates: test agents were 4 dishes per concentration, 1 dish per replicate, 4 replicates total, with 0.1% tween 80 in water without agent as a blank.
And (3) medicament treatment: under the aseptic operation condition, 45mL of PDA culture medium which is melted and sterilized in advance is quantitatively added into an aseptic conical flask according to the test treatment, the prepared concentration liquid medicine is quantitatively sucked from low concentration to high concentration by a liquid transfer device, the liquid medicine is respectively added into the conical flask, and the liquid medicine is poured into 4 culture dishes with the diameter of 9cm after being fully and uniformly shaken, so that the PDA plate containing the medicine with the corresponding concentration is prepared.
Inoculating: cutting bacterial cake from the edge of bacterial colony with sterilizing puncher under aseptic condition, inoculating bacterial cake in the center of medicated plate with inoculator, covering with bacterial cover, and culturing in dark in constant temperature incubator at 25deg.C.
Data investigation: the growth of pathogenic hyphae was investigated according to colony growth in a blank culture dish. Colony diameters (cm) were measured with a ruler, and each colony was measured once by the cross method, and the average value was taken.
Data statistics and analysis: according to the investigation result, the hypha growth inhibition rate of each treatment concentration on the target bacteria to be tested is calculated, wherein the unit is the calculated result of percentage (%) and two positions after decimal point are reserved.
D＝D 1 -D 2
Wherein:
d-colony growth diameter;
D 1 colony diameter;
D 2 -diameter of the bacterial cake.
Wherein:
i, hypha growth inhibition rate;
D 0 -the control colony increased in diameter;
D T -the agent-treated colonies increased in diameter.
And processing the data by adopting a probability value analysis method. Analyzing by DPS statistical analysis system to obtain virulence regression line and EC 50 Value and correlation coefficient R, evaluationActivity of the test agent on the biological test material.
Grand cloud Pei method: evaluating the synergistic effect of the mixed medicaments according to the co-toxicity coefficient (CTC), wherein the compounded co-toxicity coefficient CTC is more than or equal to 120 and shows the synergistic effect; ctc.ltoreq.80 shows antagonism; 80 < CTC < 120 shows additive effect.
Co-toxicity coefficient (CTC value) of the blend was calculated:
wherein:
ati—actual measured virulence index of the mixture;
S-EC of Standard Agents 50 Milligrams per liter (mg/L);
M-EC of mixture 50 Units are milligrams per liter (mg/L).
TTI＝TIA*PA+TIB*PB
Wherein:
TTI-the theoretical toxicity index of the mixture;
TI A -a medicament virulence index;
P A -the percentage of agent a in the mix, in percent (%);
TI B -B agent virulence index;
P B the percentage of the B medicament in the mixture is expressed as percentage (%).
Wherein:
ctc—co-toxicity coefficient;
ati—actual measured virulence index of the mixture;
TTI-the theoretical toxicity index of the mixture.
The test results are shown in the following table:
TABLE 1 indoor toxicity test results of prothioconazole and fludioxonil and their mixture against wheat root rot
As shown in Table 1, the test results show that the two medicaments, namely prothioconazole and fludioxonil, have different action mechanisms, and the compound use is beneficial to overcoming or delaying the development of drug resistance of bacteria and improving the control effect. The prothioconazole and the fludioxonil have good control effect on the vermicular spore bacteria, and the fludioxonil has good control effect on the EC of the vermicular spore bacteria 50 The mixture is 0.2876mg/L, and the prothioconazole and fludioxonil have synergistic effect within the range of 1:8-3:1, wherein the prothioconazole: fludioxonil with mass ratio of 2:1 has better activity and EC 50 0.2715mg/L and 195.439 co-toxicity coefficient.
TABLE 2 Protebuconazole+fludioxonil mixture and method for determining indoor toxicity of Helminthosporium umbilicus by mixing the mixture with clothianidin
Note that: 1. clothianidin: prothioconazole: the concentration in the fludioxonil mixture is the concentration of the mixture of prothioconazole and fludioxonil;
2. the clothianidin has no obvious inhibition activity on the helminthianidin at the highest concentration of 200mg/L, and EC cannot be calculated 50 And virulence regression equations.
The anabasine pesticide has no obvious activity on the helminthic vermiculella, and the anabasine pesticide has a certain inhibition effect on the growth of the helminthic vermiculella when compounded with the anabasine pesticide according to the mass ratio of the prothioconazole to the fludioxonil of 3:1.5 (2:1); wherein clothianidin: prothioconazole: the mass ratio of fludioxonil is (10-45), the fludioxonil has a synergistic effect on the helminth at a ratio of 3:1.5, and clothianidin: prothioconazole: the mass ratio of the fludioxonil is (5-8.1), and the fludioxonil has additive effect on the helminth.
Example 2: indoor toxicity test of wheat aphid
The test is based on: test reference NY/T1154.6-2006 agricultural industry standard "pesticide indoor bioassay test criteria pesticide part 6", part of the people's republic of China: insecticidal Activity test method of soaking insects.
Test target: the method comprises the steps of collecting a wheat long tube aphid (Sitobin avena), collecting an insect source from a Qingdao Ruo Kokou wheat test field in Makou, magao City, shandong, inoculating the collected wheat long tube aphid onto fresh wheat seedlings for breeding, wherein the breeding conditions are as follows: the temperature is about 22 ℃, the relative humidity is 70-80%, and the photoperiod is L, D=14h, 10h.
Instrument apparatus: electronic balance (sensing 0.1 mg), dissecting mirror, writing brush, volumetric flask, beaker, pipette, petri dish, filter paper, pin, etc.
Test agent: 97% prothioconazole technical, 98% fludioxonil technical and 98% clothianidin technical are provided by the research and development center of the sea li pharmaceutical industry group.
Other reagents: acetone (analytically pure), tween 80 (chemically pure).
And (3) preparation of a medicament: the raw materials are dissolved by acetone and then diluted by 0.1% Tween-80 aqueous solution. The mother solution of single agent is prepared respectively, proper proportion is designed according to the mixing purpose and the medicament activity, and 5 series of mass concentrations of each single agent and each group of proportion mixture are prepared according to an equal proportion method.
Test replicates: test agents were treated 4 times per concentration, 30 healthy and consistent adult aphids per replicate.
And (3) medicament treatment: selecting wheat leaves, removing winged aphids, if aphids and unhealthy adult aphids by using a writing brush, reserving 30 adult aphids with consistent health states, immersing the wheat leaves with the adult aphids in each treatment liquid medicine for 5S, taking out and sucking excessive medicines by using water absorption paper, and placing the wheat leaves in a culture dish filled with filter paper.
Feeding and observing: the treated test insects are placed in a climatic chamber with the temperature of 20+/-1 ℃ and the relative humidity of 60% -70% and the photoperiod L: D=17h: 7h for cultivation.
Experimental investigation: and (3) performing microscopic examination 48 hours after the medicament treatment, investigating the death condition of the test insects, and judging that the death condition of the test insects is that the test insects are light to form aphids by using a pin or a writing brush, wherein the death is regarded as death by the dead insects.
Data statistics and analysis: from the survey data, corrected mortality for each treatment was calculated. Calculating according to formulas (1) and (2), wherein the calculation results are reserved to two positions after decimal point:
wherein:
p-mortality in percent (%);
k, death insect number, the unit is the head;
n-total number of insects treated in units of head.
Wherein:
P 1 -correct mortality in percent (%);
P t mortality rate in percent (%);
P 0 blank mortality in percent (%).
If the control mortality is less than 5%, correction is not needed; the control mortality is between 5% and 20%, and correction is carried out according to the formula (2); control mortality was > 20% and the test was reworked.
And processing the data by adopting a probability value analysis method. Analyzing by DPS statistical analysis system to obtain virulence regression line and LC 50 And evaluating the activity of the test agent on the biological test material according to the value and the correlation coefficient R.
Grand cloud Pei method: evaluating the synergistic effect of the mixed medicaments according to the co-toxicity coefficient (CTC), wherein the compounded co-toxicity coefficient CTC is more than or equal to 120 and shows the synergistic effect; ctc.ltoreq.80 shows antagonism; 80 < CTC < 120 shows additive effect.
The co-toxicity coefficient (CTC value) of the mixture is calculated according to the formulas (3), (4) and (5):
wherein:
ati—actual measured virulence index of the mixture;
S-LC of Standard insecticide 50 Milligrams per liter (mg/L);
M-LC of the mixture 50 Units are milligrams per liter (mg/L).
TTI＝TI A *P A +TI B *P B ···········(4)
Wherein:
TTI-the theoretical toxicity index of the mixture;
TI A -a medicament virulence index;
P A -the percentage of agent a in the mix, in percent (%);
TI B -B agent virulence index;
P B the percentage of the B medicament in the mixture is expressed as percentage (%).
Wherein:
ctc—co-toxicity coefficient;
ati—actual measured virulence index of the mixture;
TTI-the theoretical toxicity index of the mixture.
The test results are shown in the following table:
TABLE 3 Prosulfas and fludioxonil mixture and method for determining indoor virulence of wheat aphids by mixing the mixture with clothianidin
Injection 1. Clothianidin: prothioconazole: the concentration in the fludioxonil mixture refers to the concentration of clothianidin;
2. prothioconazole: fludioxonil (2:1) has no obvious activity on wheat aphids when the highest concentration of 200mg/L is designed, and LC cannot be calculated 50 And virulence regression equations.
As shown by the indoor activity measurement results in Table 3, the prothioconazole and fludioxonil mixture pair is smallThe wheat aphid has no obvious activity. The anabasine pesticide clothianidin has better toxicity to wheat aphids and LC 50 3.6149mg.L respectively -1 。
Test results show that the prothioconazole and fludioxonil mixture and the neonicotinoid insecticide are prepared into a ternary compound preparation, so that the toxicity of the neonicotinoid insecticide can be obviously increased, the control effect on wheat aphids can be enhanced, and the dosage can be obviously reduced; wherein, the neonicotinoid insecticide clothianidin: prothioconazole: the mass ratio of fludioxonil is (10-45) 3:1.5, the synergistic effect is shown on wheat aphid, and clothianidin: prothioconazole: the mass ratio of the fludioxonil is (5-8.1) 3:1.5, and the additive effect is shown on wheat aphids.
Therefore, the prothioconazole, fludioxonil and clothianidin are compounded according to a proper proportion, so that the wheat root rot and wheat aphid can be effectively prevented and treated, the disease and insect prevention spectrum is expanded, the labor force and the cost are saved, and the safety is improved.
Field efficacy test
Example 3: field efficacy test of wheat root rot
The test is based on: test reference NY/T1464.16-2007 section 16 of pesticide field efficacy test guidelines: the bactericide can prevent and cure wheat root rot.
Control object: wheat root rot fungi.
Test crop: wheat (tobacco grower 21).
Test site: the soil type is black soil of rhizoma zingiberis, soil fertility and the like. The irrigation facility of the test field is good, the cultivation conditions (soil type, water and fertilizer management, planting density and growth period) of the test plot are uniform and consistent, and the test plot accords with the agricultural practice (GAP) of local science.
Dosage of the medicament: the test agents and the dosage are shown in the following table:
TABLE 4 test agents and dosage amounts
The sowing day: more clouds are generated in 10 months and 20 days in 2020, southwest wind is at level 3, the air temperature is 8-21 ℃, and the relative humidity is 86%.
Cell arrangement: the cell treatment of the test agent, the control agent and the blank control adopts random block arrangement, and the periphery of the cell is provided with protection rows.
Cell area and repetition: 30m 2 4 replicates.
The application method comprises the following steps: seed coating is carried out before wheat planting, sowing is carried out after airing, the liquid medicine is prepared according to the proportion of adding 2 liters of water into each 100kg of seed, and the sowing amount per mu is 15kg.
Experimental investigation: the experiments were investigated 2 times in total, the emergence rate was investigated in wheat Ji Miaoshi (11/6/2020), and the efficacy was investigated once after the blank was fully sick (22/2021/1).
Investigation of emergence rate: and (5) independently sowing 200 seeds in each cell, recording the emergence number of wheat during investigation, and calculating the emergence rate of the wheat.
Investigation of disease index: and (3) taking double rows for investigation of the disease condition of the basal part of the wheat stem at each point, carrying out grading investigation by taking plants as units, and recording and investigating the total plant number and the plant number of each stage of diseases.
Grading standard:
level 0: the basal part of the stem has no disease spots;
stage 1: the lesions surround less than 25% of the basal stem;
3 stages: the disease spots surround less than 26% -50% of the basal part of the stem;
5 stages: the disease spots surround the basal part of the stem by less than 51-75 percent;
7 stages: the lesions surround more than 76% of the basal stem, and the plants wilt, near death or die.
After wheat is sowed and emerged to the front of harvest, the field growth condition of the wheat is observed irregularly, and no obvious visible phytotoxicity symptoms are found.
The drug effect calculation method comprises the following steps:
the test results are shown in the following table:
TABLE 5 control effect of test agent on wheat root rot
As shown by the field efficacy test results in Table 5, the ternary mixed pesticide is applied to wheat seeds, and under the condition of the dosage of the effective components in Table 4, the average emergence rate of each treatment of the pesticide composition is 88.50-93.25% after the wheat seedlings are aligned, and the average control effect on wheat root rot is 89.02-94.01%, so that the pesticide composition has good control effect.
Example 4: wheat aphid field efficacy test
The test is based on: the test is described in GB/T17980.79-2004 section 79 of pesticide field efficacy test criterion (two): the pesticide can prevent and treat wheat aphid.
Control object: wheat aphids, mainly wheat aphids, including Sitobion avenae (Sitobion avenae), and wheat Gu Yiguan aphids (Rhopalosiphum padi), are grown in a mixed manner without wing, and if the wheat aphids, the wing aphids do not account for the total number.
Test crop: wheat (tobacco grower 21).
Test site: the soil type is black soil of rhizoma zingiberis, soil fertility and the like. The irrigation facility of the test field is good, the cultivation conditions (soil type, water and fertilizer management, planting density and growth period) of the test plot are uniform and consistent, and the test plot accords with the agricultural practice (GAP) of local science.
Dosage of the medicament: the test agents and the dosage are shown in the following table:
TABLE 6 test agents and dosage amounts
The sowing day: 10.12 days 2019, cloudy, grade 1 wind power, 10-24 ℃ of air temperature and 54% of relative humidity.
Cell arrangement: the cell treatment of the test agent, the control agent and the blank control adopts random block arrangement, and the periphery of the cell is provided with protection rows.
Cell area and repetition: 30m 2 4 replicates.
The application method comprises the following steps: seed coating is carried out before wheat planting, the seeds are sowed after airing, and the liquid medicine is prepared according to the proportion of adding 2 liters of water into the dosage of each 100kg of seeds.
Experimental investigation: the test was run 3 times in total, and the drug effect was investigated at the initial stage of aphid occurrence in the blank area, 1 time per week. Sampling 5 points in each cell, fixedly checking 20 aphid strains in each point, and checking the number of the survival aphids in the whole plant.
After wheat is sowed and emerged to the front of harvest, the field growth condition of the wheat is observed irregularly, and no obvious visible phytotoxicity symptoms are found.
The drug effect calculation method comprises the following steps:
the test results are shown in the following table:
TABLE 7 control effect of test agent on wheat aphids
As shown in the field efficacy test results of Table 7, the ternary mixed pesticide of the invention has good control effect on wheat aphids under the condition that the dosage of the active ingredients is 118g/100kg of seeds, the first investigation control effect is 87.44-93.23%, the second investigation control effect is 86.14-90.33%, the third investigation control effect is 84.00-88.32%, the harm of the wheat aphids can be effectively controlled, the wheat aphids are safe, and other organisms are not affected.
Through indoor toxicity measurement and field efficacy test, the prothioconazole, fludioxonil and clothianidin disclosed by the invention have a good control effect on wheat root rot and wheat aphids after being compounded. The pesticide composition or the preparation thereof obtained by compounding has remarkable prevention effect, is superior to a single dose in the aspects of delaying the generation of drug resistance and prolonging the drug retention, and simultaneously comprises the active ingredients of prothioconazole, fludioxonil and clothianidin as seed treatment suspending agents. In addition, no phytotoxicity of the compound medicament to crops is found in the test, which proves that the production cost and the use cost can be reduced and the pesticide composition or the pesticide preparation is safe to crops under the condition that the sterilization synergy of the obtained pesticide composition or the pesticide preparation is improved.
While the invention has been described in detail in the foregoing general description and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto, and it is therefore intended that the invention as defined in the appended claims be interpreted as broadly as possible without departing from the spirit of the invention.
Claims (10)
1. The application of the pesticide composition containing prothioconazole in preventing and controlling wheat diseases and insect pests is characterized in that the pesticide composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is prothioconazole, the active ingredient B is fludioxonil, and the pesticide composition further comprises clothianidin.
2. The use according to claim 1, wherein the mass ratio of the active ingredient a to the active ingredient B is 1:10 to 10:1;
preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:8-3:1;
more preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:4-5:2.
3. Use according to claim 1, characterized in that the content of active ingredient a in the pesticide composition is 0.5-50%, preferably 1-10% based on 100wt% of the total weight of the pesticide composition;
more preferably, the content of the active ingredient A in the pesticide composition is 1% -5%.
4. Use according to claim 1, characterized in that the content of active ingredient B in the pesticide composition is 0.5-50%, preferably 1-10% based on 100wt% of the total weight of the pesticide composition;
more preferably, the content of the active ingredient B in the pesticide composition is 1% -5%.
5. Use according to claim 1, characterized in that the content of clothianidin in the pesticide composition is 10-50%, preferably 10-45% based on 100wt% of the total weight of the pesticide composition;
more preferably, the content of the clothianidin in the pesticide composition is 10% -35%.
6. The use according to claim 1, wherein the pesticide composition further comprises an adjuvant selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, warning colors, film formers, synergists and carriers.
7. The use according to claim 6, wherein the pesticide composition is in the form of any one of a seed treatment solid preparation or a seed treatment liquid preparation.
8. The use according to claim 7, wherein the pesticide composition is in the form of any one of a seed treatment dry powder, a seed treatment dispersible powder, a seed treatment liquid, a seed treatment emulsion or a seed treatment suspension;
preferably, the pesticide composition is in the form of a seed treatment suspending agent.
9. The use according to claim 1, wherein the wheat disease is wheat root rot, wheat rust, wheat powdery mildew, wheat leaf blight, wheat scab, wheat smut, wheat sheath blight, wheat take-all, wheat black embryo and/or wheat yellow dwarf;
the wheat insect pest is wheat aphid, wheat spider mite, wheat pulp sucking insect, myxoma, flammulina velutipes and/or wheat root bug;
preferably, the wheat disease is wheat root rot and the wheat pest is wheat aphid.
10. Use according to claim 1, characterized in that the pesticidal composition according to any one of claims 1-9 is applied to a medium in which diseases or insect pests occur.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310836251.2A CN116849222A (en) | 2023-07-10 | 2023-07-10 | Application of prothioconazole-containing pesticide composition in preventing and controlling diseases and insect pests of wheat |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310836251.2A CN116849222A (en) | 2023-07-10 | 2023-07-10 | Application of prothioconazole-containing pesticide composition in preventing and controlling diseases and insect pests of wheat |
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| CN116849222A true CN116849222A (en) | 2023-10-10 |
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| CN202310836251.2A Pending CN116849222A (en) | 2023-07-10 | 2023-07-10 | Application of prothioconazole-containing pesticide composition in preventing and controlling diseases and insect pests of wheat |
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| Country | Link |
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| CN (1) | CN116849222A (en) |
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